NAKATA Masao 中田昌男

… Alternative Names

中田昌男ナカタマサオ

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Researcher Number	30368641
Other IDs
Affiliation (Current)	2023: 川崎医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2015 – 2021: 川崎医科大学, 医学部, 教授 2013: 川崎医科大学, 医学部, 教授
Review Section/Research Field	Except Principal Investigator Respiratory surgery / Basic Section 55040:Respiratory surgery-related
Keywords	Except Principal Investigator 非小細胞肺癌 / NK細胞 / NKG2Dリガンド / 悪性胸膜中皮腫 / EGFR / HER2 / PD-L1 / 免疫チェックポイント / 腫瘍免疫 / NK細胞傷害活性 … More / 癌免疫療法 / 肺癌 / NK cell / NKG2D ligand / lung cancer / 免疫逃避 / IFNγ / HER3 / microRNA / 外科 / トランスレーショナルリサーチ / 癌 / 免疫学 / 発現制御 / T細胞 / ＮKG2Dリガンド Less

悪性胸膜中皮腫に対するNK細胞に関連した免疫調節分子の発現制御療法の開発
- Principal Investigator
  
  沖田理貴
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  National Hospital Organization,Yamaguchi - Ube Medical Center
Immunoescape mechanisms of thoracic malignancy via EGFR signaling
- Principal Investigator
  
  Okita Riki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  National Hospital Organization,Yamaguchi - Ube Medical Center
  Kawasaki Medical School
Immunoescape from innnate/adoptive antitumor immunity via EGF family receptor in non-small cell lung cancer
- Principal Investigator
  
  Okita Riki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Kawasaki Medical School

All 2021 2019 2018 2017 2016 2015 2013

All Journal Article Presentation

[Journal Article] Tofacitinib overcomes an IFNγ‐induced decrease in NK cell‐mediated cytotoxicity via the regulation of immune‐related molecules in LC‐2/ad2021
- Author(s)
  Okita Riki、Shimizu Katsuhiko、Nojima Yuji、Saisho Shinsuke、Nakata Masao
- Journal Title
  
  Thoracic Cancer
  
  Volume: 12 Pages: 775-782
- DOI
  10.1111/1759-7714.13847
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09298
[Journal Article] Effect of platinum-based chemotherapy on the expression of natural killer group 2 member D ligands, programmed cell death-1 ligand 1 and HLA class I in non-small cell lung cancer2019
- Author(s)
  Okita Riki、Ai Maeda、Shimizu Katsuhiko、Yuji Nojima、Shinsuke Saisho、Nakata Masao
- Journal Title
  
  ONCOLOGY REPORTS
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10696
[Journal Article] Comparative study of the PD-L1 expression and CD8+ tumor-infiltrating lymphocyte between surgically resected and matched re-biopsy specimens in recurrent non-small cell lung cancer</p>2019
- Author(s)
  Shimizu Katsuhiko、Okita Riki、Saisho Shinsuke、Maeda Ai、Nojima Yuji、Nakata Masao
- Journal Title
  
  Therapeutics and Clinical Risk Management
  
  Volume: Volume 15 Pages: 605-612
- DOI
  10.2147/tcrm.s189320
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10696
[Journal Article] Clinicopathological relevance of tumor expression of NK group 2 member D ligands in resected non-small cell lung cancer2019
- Author(s)
  Okita Riki、Maeda Ai、Shimizu Katsuhiko、Nojima Yuji、Saisho Shinsuke、Nakata Masao
- Journal Title
  
  Oncotarget
  
  Volume: 10 Pages: 6805-6815
- DOI
  10.18632/oncotarget.27308
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10696
[Journal Article] Effect of platinum-based chemotherapy on the expression of natural killer group?2 member?D ligands, programmed cell death?1 ligand?1 and HLA class?I in non?small cell lung cancer2019
- Author(s)
  Okita Riki、Maeda Ai、Shimizu Katsuhiko、Nojima Yuji、Saisho Shinsuke、Nakata Masao
- Journal Title
  
  Oncology Reports
  
  Volume: 42 Pages: 839-848
- DOI
  10.3892/or.2019.7185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10696
[Journal Article] Impact of COX2 Inhibitor for Regulation of PD-L1 Expression in Non-small Cell Lung Cancer2018
- Author(s)
  SHIMIZU KATSUHIKO、OKITA RIKI、SAISHO SHINSUKE、MAEDA AI、NOJIMA YUJI、NAKATA MASAO
- Journal Title
  
  Anticancer Research
  
  Volume: 38 Pages: 4637-4644
- DOI
  10.21873/anticanres.12768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10696
[Journal Article] Epithelial-mesenchymal transition-induced metastasis could be a bait for natural killer cells2018
- Author(s)
  Okita Riki、Shimizu Katsuhiko、Nakata Masao
- Journal Title
  
  Journal of Thoracic Disease
  
  Volume: 10
- DOI
  10.21037/jtd.2018.08.19
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10696
[Journal Article] PD-L1 overexpression is partially regulated by EGFR/HER2 signaling and associated with poor prognosis in patients with non-small-cell lung cancer2017
- Author(s)
  Riki Okita, Ai Maeda, Katsuhiko Shimizu, Yuji Nojima, Shinsuke Saisho, Masao Nakata.
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: - Pages: 865-876
- DOI
  10.1007/s00262-017-1986-y
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K10696
[Journal Article] Urinary levels of prostaglandin E2 are positively correlated with intratumoral infiltration of Foxp3+ regulatory T cells in non-small cell lung cancer2017
- Author(s)
  Shimizu Katsuhiko、Okita Riki、Saisho Shinsuke、Maeda Ai、Nojima Yuji、Nakata Masao
- Journal Title
  
  Oncol Lett
  
  Volume: 14 Pages: 1615-1620
- DOI
  10.3892/ol.2017.6340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10696
[Journal Article] Prognostic value of Cox-2 and PD-L1 expression and its relationship with tumor-infiltrating lymphocytes in resected lung adenocarcinoma.2017
- Author(s)
  Shimizu K, Okita R, Saisho S, Maeda A, Nojima Y, Nakata M.
- Journal Title
  
  Cancer Manag Res
  
  Volume: 9 Pages: 741-750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10696
[Journal Article] MHC class I chain‑related molecule A and B expression is upregulated by cisplatin and associated with good prognosis in patients with non‑small cell lung cancer2016
- Author(s)
  Riki Okita1, Takuro Yukawa, Yuji Nojima, Ai Maeda, Shinsuke Saisho, Katsuhiko Shimizu, Masao Nakata
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 65 Pages: 499-509
- DOI
  10.1007/s00262-016-1814-9
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25462189
[Journal Article] Lapatinib enhances trastuzumab-mediated antibody-dependent cellular cytotoxicity via upregulation of HER2 in malignant mesothelioma cells2015
- Author(s)
  Riki Okita , Katsuhiko Shimizu, Yuji Nojima, Takuro Yukawa, Ai Maeda, Shinsuke Saisho, Masao Nakata.
- Journal Title
  
  Oncology Reports
  
  Volume: 34 Pages: 2864-2870
- DOI
  10.3892/or.2015.4314
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25462189
[Journal Article] Contrasting effects of the cytotoxic anticancer drug gemcitabine and the EGFR tyroshine kinase inhibitor gefitinib on NK cell-mediated cytotoxicity via regulation of NKG2D ligand in non-small-cell lung cancer cells2015
- Author(s)
  Okita R, Wolf D, Yasuda K, Maeda A, Yukawa T, Saisho S, Shimizu K, Yamaguchi Y, Oka M, Nakayama E, Lundqvist A, Kiessling R, Seliger B, Nakata M.
- Journal Title
  
  Plos One
  
  Volume: 10
- DOI
  10.1371/journal.pone.0139809
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09235, KAKENHI-PROJECT-25430161, KAKENHI-PROJECT-25462189
[Presentation] JAK STAT inhibitor overcomes interferon g reduced, NK cell mediated cytotoxicity in non small cell lung cancer cells2019
- Author(s)
  Okita Riki、Shimizu Katsuhiko、Nojima Yuji、Saisho Shinsuke、Nakata Masao
- Organizer
  European Society for Medical Oncology Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10696
[Presentation] Decreased expression of ULBP4 without loss of MHC class I is an independent poor prognostic factor in resected NSCLC2019
- Author(s)
  沖田理貴、前田　愛、清水克彦、野島雄史、最相晋輔、中田昌男
- Organizer
  第72回日本胸部外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K10696
[Presentation] 非小細胞肺癌切除検体におけるPD-L1とMICA/Bの発現解析2018
- Author(s)
  沖田理貴、清水克彦、野島雄史、最相晋輔、中田昌男
- Organizer
  第15回日本免疫治療学研究会学術集会
- Data Source
  KAKENHI-PROJECT-16K10696
[Presentation] 非小細胞肺癌細胞における抗リウマチ薬TofacitinibのPD-L1発現抑制効果2018
- Author(s)
  沖田理貴、清水克彦、野島雄史、最相晋輔、中田昌男
- Organizer
  第35回日本呼吸器外科学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K10696
[Presentation] Relationship between PD-L1 expression and EGFR/HER2 signaling in non-small-cell lung cancer2017
- Author(s)
  Okita R, Maeda A, Shimizu K, Nojima Y, Saisho S, Nakata M.
- Organizer
  18th World Conference on Lung Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10696
[Presentation] Survival of non-small cell lung cancer patients predicted from expression of PD-L1, HLA class I and MICA/B on tumor cells2017
- Author(s)
  Okita R, Maeda A, Yukawa T, Shimizu K, Nojima Y, Saisho S, Nakata M.
- Organizer
  European Society for Medical Oncology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10696
[Presentation] 非小細胞肺癌切除例におけるNKG2DリガンドULBP1-6の発現と臨床病理学的因子との関連性の検討2017
- Author(s)
  沖田理貴, 前田　愛, 清水克彦, 野島雄史, 最相晋輔, 中田昌男
- Organizer
  第70回日本胸部外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K10696
[Presentation] シスプラチン併用導入化学療法が非小細胞肺癌における PD-L1発現に及ぼす影響2017
- Author(s)
  沖田理貴, 前田　愛, 野島雄史, 最相晋輔, 清水克彦, 中田昌男
- Organizer
  第34回日本呼吸器外科学会総会
- Data Source
  KAKENHI-PROJECT-16K10696
[Presentation] PD-L1 expression predicts poor prognosis and is correlated with EGFR status in patients with non-small-cell lung cancer2016
- Author(s)
  沖田理貴, 野島雄史, 前田　愛, 最相晋輔, 清水克彦, 中田昌男
- Organizer
  第14回日本臨床腫瘍学会学術集会
- Place of Presentation
  神戸国際会議場、神戸市、兵庫県
- Data Source
  KAKENHI-PROJECT-16K10696
[Presentation] Repeated exposure to cisplatin enhances NK cell-mediated cytotoxicity via up-regulation of NKG2D ligands in non-small cell lung cancer cells2016
- Author(s)
  Okita R, Nojima Y, Maeda A, Saisho S, Shimizu K, Nakata M
- Organizer
  European Society for Medical Oncology 2016
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-16K10696
[Presentation] 非小細胞肺癌におけるPD-L1発現とHER2シグナルとの関連性の検討2016
- Author(s)
  沖田理貴, 中田昌男
- Organizer
  第29回日本バイオセラピィ学会学術集会総会
- Place of Presentation
  久留米シティプラザ、久留米市、福岡県
- Data Source
  KAKENHI-PROJECT-16K10696
[Presentation] 非小細胞肺癌におけるNKG2DリガンドMICA/B発現の意義：切除例における予後との関連ならびにシスプラチンによるMICA/B発現誘導効果に関する検討2015
- Author(s)
  沖田理貴、湯川拓郎、野島雄史、前田　愛、最相晋輔、清水克彦、中田昌男
- Organizer
  第28回日本バイオセラピィ学会学術集会総会
- Place of Presentation
  川越東武ホテル、川越市、埼玉県
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-25462189
[Presentation] 悪性胸膜中皮腫細胞においてlapatinibはtrastuzumabの抗体依存性細胞傷害活性を増強する2015
- Author(s)
  沖田理貴、野島雄史、前田　愛、最相晋輔、清水克彦、中田昌男
- Organizer
  第6回　Japan Mesothelioma Interest Group 研究会
- Place of Presentation
  北九州国際会議場、北九州市、福岡県
- Year and Date
  2015-11-14
- Data Source
  KAKENHI-PROJECT-25462189
[Presentation] Overexpression of NK cell-activating ligand MICA/B correlates with superior outcomes and might be a therapeutic target for chemoimmunotherapy in non-small-cell lung cancer.2015
- Author(s)
  Riki Okita, Takuro Yukawa, Yuji Nojima, Ai Maeda, Shinsuke Saisho, Katsuhiko Shimizu, Masao Nakata
- Organizer
  ESMO Asia 2015
- Place of Presentation
  Singapore, Singapore
- Year and Date
  2015-12-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462189
[Presentation] 化学療法前後における非小細胞肺癌細胞のNKG2Dリガンド発現解析2015
- Author(s)
  沖田理貴, 保田紘一郎, 前田　愛, 湯川拓郎, 最相晋輔, 清水克彦, 中田昌男
- Organizer
  第32回日本呼吸器外科学会総会
- Place of Presentation
  サンポートホール高松、高松市、香川県
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-25462189
[Presentation] Lapatinib enhances trastuzumab-mediated antibody-dependent cellular cytotoxicity by upregulating HER2 in malignant pleural mesothelioma cells.2015
- Author(s)
  Riki Okita, Shinji Nojima, Ai Maeda, Takuro Yukawa, Shinsuke Saisho, Katsuhiko Shimizu, Masao Nakata.
- Organizer
  The 2015 European Cancer Congress
- Place of Presentation
  Vienna, Austria
- Year and Date
  2015-09-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462189
[Presentation] Anticancer drugs effect on NK cell-mediated cytotoxicity via the regulation of NKG2D ligand expression in non-small cell lung cancer cells2013
- Author(s)
  Okita R, Nojima Y, Yasuda K, Maeda A, Yukawa T, Saisho S, Hirami Y, Shimizu K, Nakata M
- Organizer
  European Cancer Congress 2013
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-25462189
[Presentation] 非小細胞肺癌細胞において抗腫瘍薬がNK細胞傷害活性に与える影響の解析2013
- Author(s)
  沖田理貴、野島雄史、保田紘一郎、前田　愛、湯川拓郎、最相晋輔、清水克彦、中田昌男
- Organizer
  第54回日本肺癌学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25462189
[Presentation] EGFR signaling effects on NK cell-mediated cytotoxicity via NKG2D ligands-NKG2D interaction in non-small cell lung cancer cells2013
- Author(s)
  Okita R, Nojima Y, Yasuda K, Maeda A, Yukawa T, Saisho S, Hirami Y, Shimizu K, Nakata M
- Organizer
  15th World Conference on Lung Cancer
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-25462189

1. Okita Riki (90467762)

# of Collaborated Projects: 3 results

# of Collaborated Products: 32 results
2. Kiessling Rolf

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. OKA Mikio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 中山睿一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAKATA Masao 中田 昌男

中田 昌男 ナカタ マサオ

Research Projects

Research Products

Co-Researchers

悪性胸膜中皮腫に対するNK細胞に関連した免疫調節分子の発現制御療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Immunoescape mechanisms of thoracic malignancy via EGFR signaling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Immunoescape from innnate/adoptive antitumor immunity via EGF family receptor in non-small cell lung cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Tofacitinib overcomes an IFNγ‐induced decrease in NK cell‐mediated cytotoxicity via the regulation of immune‐related molecules in LC‐2/ad2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of platinum-based chemotherapy on the expression of natural killer group 2 member D ligands, programmed cell death-1 ligand 1 and HLA class I in non-small cell lung cancer2019

Author(s)

Journal Title

Data Source

[Journal Article] Comparative study of the PD-L1 expression and CD8+ tumor-infiltrating lymphocyte between surgically resected and matched re-biopsy specimens in recurrent non-small cell lung cancer</p>2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinicopathological relevance of tumor expression of NK group 2 member D ligands in resected non-small cell lung cancer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of platinum-based chemotherapy on the expression of natural killer group?2 member?D ligands, programmed cell death?1 ligand?1 and HLA class?I in non?small cell lung cancer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of COX2 Inhibitor for Regulation of PD-L1 Expression in Non-small Cell Lung Cancer2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epithelial-mesenchymal transition-induced metastasis could be a bait for natural killer cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PD-L1 overexpression is partially regulated by EGFR/HER2 signaling and associated with poor prognosis in patients with non-small-cell lung cancer2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Urinary levels of prostaglandin E2 are positively correlated with intratumoral infiltration of Foxp3+ regulatory T cells in non-small cell lung cancer2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic value of Cox-2 and PD-L1 expression and its relationship with tumor-infiltrating lymphocytes in resected lung adenocarcinoma.2017

Author(s)

Journal Title

Data Source

[Journal Article] MHC class I chain&#8209;related molecule A and B expression is upregulated by cisplatin and associated with good prognosis in patients with non&#8209;small cell lung cancer2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lapatinib enhances trastuzumab-mediated antibody-dependent cellular cytotoxicity via upregulation of HER2 in malignant mesothelioma cells2015

Author(s)

Journal Title

DOI

NAKATA Masao 中田昌男

中田昌男ナカタマサオ

[Journal Article] MHC class I chain‑related molecule A and B expression is upregulated by cisplatin and associated with good prognosis in patients with non‑small cell lung cancer2016