Tanaka Satoshi 田中敏

… Alternative Names

TANAKA Satoshi 田中敏

Less

Researcher Number	30374250
Other IDs
Affiliation (Current)	2025: 北海道大学, 医学研究院, 特任准教授
Affiliation (based on the past Project Information) *help	2025: 北海道大学, 医学研究院, 特任准教授 2018 – 2022: 北海道大学, 医学研究院, 特任准教授 2017: 北海道大学, 医学(系)研究科(研究院), その他 2016: 北海道大学, 医学研究科, 特任准教授 2014 – 2016: 札幌医科大学, 医学部, 講師 2008 – 2012: 札幌医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Human pathology / Basic Section 49020:Human pathology-related Except Principal Investigator Human pathology
Keywords	Principal Investigator redox / thioredoxin / ジスルフィド結合 / タイト結合 / シグナル伝達 / ユビキチン / occludin / オクルディン / 酸化ストレス / 分子病理 … More Except Principal Investigator … More タイト結合 / ヒト鼻粘膜 / 細胞・組織 / 病理学 / 子宮頸部 / 子宮頸部腺癌 / 治療・診断マーカー / 子宮頚部腺癌 / 子宮頚部 / EMT / PKC / クローディン / 緑膿菌 / 肝線維症 / 膵癌 / 免疫学 / アレルギー・ぜんそく / RSウイルス / シグナル伝達 / RSウィルス / TLR / 自然免疫 / ビタミンD受容体欠損マウス / Ca吸収機構 / Toll-like receptor / claudin / TSLP / 樹状細胞 / 生体機能利用 / サイトカイン / バリア機能 / 肝(黄疸) / 膵管上皮 / 鼻アレルギー / Ca吸収 / 糖尿病網膜症 Less

ジスルフィド結合を介したタイト結合の機能解明：酸化還元環境と細胞増殖の関連Principal Investigator
- Principal Investigator
  
  田中敏
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Hokkaido University
The regulation of tight junction function via disulfide bond formation as a redox signalingPrincipal Investigator
- Principal Investigator
  
  Tanaka Satoshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Hokkaido University
Tight junction regulates cell proliferation via disulfide bond formationPrincipal Investigator
- Principal Investigator
  
  Tanaka Satoshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Hokkaido University
The function of disulfide bond in tight junction protein, as an oxidative sensorPrincipal Investigator
- Principal Investigator
  
  TANAKA Satoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Hokkaido University
  Sapporo Medical University
Evaluation of potential clinical application of tight junction proteins in cervical adenocarcinoma
- Principal Investigator
  
  Takasawa Akira
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
Patho-physiology of the tight junction-mainly focusing on human normal epithelial cells.
- Principal Investigator
  
  SAWADA Norimasa
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
The analyses of tight junction formation via disulfide bondPrincipal Investigator
- Principal Investigator
  
  TANAKA Satoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
Regulation of human nasal mucosal barrier by tight junctions via innate immunity
- Principal Investigator
  
  KOJIMA Takashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University
Pathobiology of the tight junction : from cell biology of paracellular pathway to bed-side
- Principal Investigator
  
  SAWADA Norimasa
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Sapporo Medical University

All 2022 2021 2019 2018 2017 2016 2015 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Book

[Book] 細胞間結合装置.病気の分子形態学2011
- Author(s)
  小島隆, 村田雅樹, 高澤啓, 田中敏, 澤田典均
- Total Pages
  4
- Publisher
  日本臨床分子形態学会編.学際企画
- Data Source
  KAKENHI-PROJECT-22590336
[Book] 細胞間結合装置、日本臨床分子形態学会編、病気の分子形態学、学際企画2011
- Author(s)
  小島隆、村田雅樹、高澤啓、田中敏、澤田典均
- Data Source
  KAKENHI-PROJECT-22590336
[Journal Article] Cytotoxicity of Clostridium perfringens enterotoxin depends on the conditions of claudin-4 in ovarian carcinoma cells2018
- Author(s)
  Tanaka S, Aoyama T, Ogawa M, Takasawa A, Murata M, Osanai M, Saito T, Sawada N
- Journal Title
  
  Exp Cell Res
  
  Volume: 371 Issue: 1 Pages: 278-286
- DOI
  10.1016/j.yexcr.2018.08.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08697, KAKENHI-PROJECT-17K08698, KAKENHI-PROJECT-17K08735, KAKENHI-PROJECT-16K08693
[Journal Article] Analysis of the expression and localization of tight junction transmembrane proteins, claudin-1, -4, -7, occludin and JAM-A, in human cervical adenocarcinoma.2016
- Author(s)
  Akimoto T, Takasawa A, Murata M, Kojima Y, Takasawa K, Nojima M, Aoyama T, Hiratsuka Y, Ono Y, Tanaka S, Osanai M, Hasegawa T, Saito T, Sawada N.
- Journal Title
  
  Histology and Histopathology
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460421
[Journal Article] Nuclear localization of tricellulin promotes the oncogenic property of pancreatic cancer2016
- Author(s)
  Akira Takasawa, Masaki Murata, Kumi Takasawa, Yusuke Ono, Makoto Osanai, Satoshi Tanaka, Masanori Nojima, Tsuyoshi Kono, Koichi Hirata, Takashi Kojima, Norimasa Sawada
- Journal Title
  
  Scientific Reports
  
  Volume: - Issue: 1
- DOI
  10.1038/srep33582
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460421, KAKENHI-PROJECT-15K08350
[Journal Article] Claudins-4 and -7 might be valuable markers to distinguish hepatocellular carcinoma from cholangiocarcinoma2016
- Author(s)
  Yusuke Ono, Yutaro Hiratsuka, Masaki Murata, Akira Takasawa, Rieko Fukuda, Masanori Nojima, Satoshi Tanaka, Makoto Osanai, Koichi Hirata, Norimasa Sawada
- Journal Title
  
  Virchows Archiv
  
  Volume: 469 Issue: 4 Pages: 417-426
- DOI
  10.1007/s00428-016-1984-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460421, KAKENHI-PROJECT-16K08693
[Journal Article] Aberrant expression of claudin-4 and -7 in hepatocytes in the cirrhotic human liver.2015
- Author(s)
  Tsujiwaki M, Murata M, Takasawa A, Hiratsuka Y, Fukuda R, Sugimoto K, Ono Y, Nojima M, Tanaka S, Hirata K, Kojima T, Sawada N.
- Journal Title
  
  Med Mol Morphol.
  
  Volume: 48(1) Issue: 1 Pages: 33-43
- DOI
  10.1007/s00795-014-0074-z
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-26460421, KAKENHI-PROJECT-15K08350
[Journal Article] An immunohistochemical marker panel including claudin-18, maspin, and p53 improves diagnostic accuracy of bile duct neoplasms in surgical and presurgical biopsy specimens.2015
- Author(s)
  Keira Y, Takasawa A, Murata M, Nojima M, Takasawa K, Ogino J, Higashiura Y, Sasaki A, Kimura Y, Mizuguchi T, Tanaka S, Hirata K, Sawada N, Hasegawa T.
- Journal Title
  
  Virchows Arch.
  
  Volume: 466(3) Issue: 3 Pages: 265-277
- DOI
  10.1007/s00428-014-1705-4
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-25293289, KAKENHI-PROJECT-26460421
[Journal Article] Curcumin prevents replication of respiratory syncytial virus and the epithelial responses to it in human nasal epithelial cells.2013
- Author(s)
  Obata K, Kojima T, Masaki T, Okabayashi T, Yokota S, Hirakawa S, Nomura K, Takasawa A, Murata M, Tanaka S, Fuchimoto J, Fujii N, Tsutsumi H, Himi T, Sawada N.
- Journal Title
  
  PLoS One
  
  Volume: 8(9)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390089
[Journal Article] Protein kinase Cα inhibitor protects against downregulation of claudin-1 during epithelial-mesenchymal transition of pancreatic cancer.2013
- Author(s)
  Kyuno D, Kojima T, Yamaguchi H, Ito T, Kimura Y, Imamura M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N.
- Journal Title
  
  Carcinogenesis
  
  Volume: 34(6) Pages: 1232-1243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390089
[Journal Article] Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions2013
- Author(s)
  Takasawa A, Kojima T, Ninomiya T, Tsujiwaki M, Murata M, Tanaka S, Sawada N
- Journal Title
  
  Cell Tissue Res
  
  Volume: 351(1) Issue: 1 Pages: 73-84
- DOI
  10.1007/s00441-012-1512-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-24790355
[Journal Article] Regulation of tight junctions by sex hormones in normal human endometrial epithelial cells and uterus cancer cell line Sawano.2013
- Author(s)
  Someya M, Kojima T, Ogawa M, Ninomiya T, Nomura K, Takasawa A, Murata M, Tanaka S, Saito T, Sawada N.
- Journal Title
  
  Cell Tissue Res.
  
  Volume: 354 Issue: 2 Pages: 481-494
- DOI
  10.1007/s00441-013-1676-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-24790355
[Journal Article] Expression of claudins 7 and 18 in pancreatic ductal adenocarcinoma: association with features of differentiation2012
- Author(s)
  Soini Y, Takasawa A, Eskelinen M, Juvonen P, Karja V, Hasegawa T, Murata M, Tanaka S, Kojima T, Sawada N
- Journal Title
  
  J Clin Pathol
  
  Volume: 65(5) Issue: 5 Pages: 431-436
- DOI
  10.1136/jclinpath-2011-200400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-24790355
[Journal Article] An undifferentiated embryonal sarcoma of the liver containing adipophilin-positive vesicles in an adult with massive sinusoidal invasion.2012
- Author(s)
  Tanaka S, Takasawa A, Fukasawa Y, Hasegawa T, Sawada N.
- Journal Title
  
  Int J Clin Exp Pathol
  
  Volume: 5(8) Pages: 824-829
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336
[Journal Article] An undifferentiated embryonal sarcoma of the liver containing adipophilin-positive vesicles in an adult with massive sinusoidal invasion2012
- Author(s)
  Tanaka S*, Takasawa A, Fukasawa Y, Hasegawa T, Sawada N
- Journal Title
  
  Int J Clin Exp Pathol
  
  Volume: 5(8) Pages: 824-829
- URL
  http://www.ijcep.com/files/ijcep1207003.pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336
[Journal Article] Epidermal growth factor modulates claudins and tight junctional functions in ovarian cancer cell lines2012
- Author(s)
  Ogawa M, Kojima T, Someya M, Nomura K, Takasawa A, Murata M, Tanaka S, Saito T, Sawada N
- Journal Title
  
  Histochem Cell Biol
  
  Volume: 138(2) Issue: 2 Pages: 323-338
- DOI
  10.1007/s00418-012-0956-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336, KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-24790355
[Journal Article] Claudin-4-targeted therapy using Clostridium perfringens enterotoxin for prostate cancer2012
- Author(s)
  Maeda T, Murata M, Chiba H, Takasawa A, Tanaka S, Kojima T, Masumori N, Tsukamoto T, Sawada N
- Journal Title
  
  Prostate
  
  Volume: 72(4) Issue: 4 Pages: 351-360
- DOI
  10.1002/pros.21436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-23659187, KAKENHI-PROJECT-24390089, KAKENHI-PROJECT-24790355
[Journal Article] Downregulation of tight junction-associated MARVEL protein marvelD3 during epithelial-mesenchymal transition in human pancreatic cancer cells2011
- Author(s)
  Kojima T, Takasawa A, Kyuno D, Ito T, Yamaguchi H, Hirata K, Tsujiwaki M, Murata M, Tanaka S, Sawada N
- Journal Title
  
  Exp Cell Res
  
  Volume: 317(16) Issue: 16 Pages: 2288-2298
- DOI
  10.1016/j.yexcr.2011.06.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336, KAKENHI-PROJECT-23590404
[Journal Article] Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-・via distinct NF-・B pathways in human nasal epithelial cells2011
- Author(s)
  Ohkuni T, Kojima T , Ogasawara N, Masaki T, Fuchimoto J, Kamekura R, Koizumi J, Ichimiya S, Murata M, Tanaka S, Himi T, Sawada N
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 250 Issue: 1 Pages: 29-38
- DOI
  10.1016/j.taap.2010.09.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336, KAKENHI-PROJECT-23390398, KAKENHI-PROJECT-23590404, KAKENHI-PROJECT-23590405
[Journal Article] Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells.2011
- Author(s)
  Ohkuni T, Kojima T, Ogasawara N, Masaki T, Fuchimoto J, Kamekura R, Koizumi JI, Ichimiya S, Murata M, Tanaka S, Himi T, Sawada N
- Journal Title
  
  Toxicol Appl Pharmacol. 250
  
  Pages: 29-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590346
[Journal Article] Transcriptional regulation of claudin-18 via specific protein kinase Csignaling pathway and modification of DNA-methylation in human pancreatic cancer cells2011
- Author(s)
  Ito T, Kojima T, Yamaguchi H, Kyuno D, Kimura Y, Imamura M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N
- Journal Title
  
  J Cell Biochem
  
  Volume: 112(7) Pages: 1761-1772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336
[Journal Article] An NF-・B signaling pathway via PKC・regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells2011
- Author(s)
  Masaki T, Kojima T, Okabayashi T, Ogasawara N, Ohkuni T, Obata K, Takasawa A, Murata M, Tanaka S, Hirakawa S, Fuchimoto J, Ninomiya T, Fujii N, Tsutsumi H, Himi T, Sawada N
- Journal Title
  
  Mol Biol Cell
  
  Volume: 22(13) Issue: 13 Pages: 2144-2156
- DOI
  10.1091/mbc.e10-11-0875
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336, KAKENHI-PROJECT-23590404
[Journal Article] Protein kinase Cα inhibitor enhances the sensitivity of human pancreaticcancer HPAC cells to Clostridium perfringens enterotoxin via claudin-42011
- Author(s)
  Kyuno D, Kojima T, Ito T, Yamaguchi H, Tsujiwaki M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N
- Journal Title
  
  Cell Tissue Res
  
  Volume: 346(3) Pages: 369-381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336
[Journal Article] Transcriptional regulation of claudin-18 via specific protein kinase C signaling pathways and modification of DNA methylation in human pancreatic cancaer cells2011
- Author(s)
  Ito T, Kojima T, Yamaguchi H, Kyuno D, Kimura Y, Imamura M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N
- Journal Title
  
  J Cell Biochem
  
  Volume: 112(7) Issue: 7 Pages: 1761-72
- DOI
  10.1002/jcb.23095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336, KAKENHI-PROJECT-23590404
[Journal Article] Downregulation of tight junction-associated MARVEL protein marvelD3during epithelial-mesenchymal transition in human pancreatic cancer cells2011
- Author(s)
  Kojima T, Takasawa A, Kyuno D, Ito T, Yattiaguchi H, Hirata K, Tsujiwaki M, Murata M, Tanaka S, Sawada N
- Journal Title
  
  Exp Cell Res
  
  Volume: 317(16) Pages: 2288-2298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336
[Journal Article] Protein kinase Calpha inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-42011
- Author(s)
  Kyuno D, Kojima T, Ito T, Yamaguchi H, Tsujiwaki M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N
- Journal Title
  
  Cell Tiisue Res
  
  Volume: 346(3) Issue: 3 Pages: 369-81
- DOI
  10.1007/s00441-011-1287-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336
[Journal Article] Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells.2010
- Author(s)
  Kamekura R, Kojima T, Takashima A, Koizumi JI, Ogasawara N, Go M, Takano KI, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N
- Journal Title
  
  Histochem Cell Biol 133
  
  Pages: 339-348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] PPARγ agonists upregulate the barrier function of tight junctions via a PKC pathway in human nasal epithelial cells.2010
- Author(s)
  Ogasawara N, Kojima T, Go M, Ohkuni T, Koizumi J, Kamekura R, Masaki T, Murata M, Tanaka S, Fuchimoto J, Himi T, Sawada N
- Journal Title
  
  Pharmacol Res 61
  
  Pages: 489-498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590346
[Journal Article] Transcriptional control of tight junction proteins via a protein kinase C signal pathway in human telomerase reverse transcriptase-transfected human pancreatic duct epithelial cells.2010
- Author(s)
  Yamaguchi H, Kojima T, Ito T, Kimura Y, Imamura M, Son S, Koizumi J, Murata M, Nagayama M, Nobuoka T, Tanaka S, Hirata K, Sawada N
- Journal Title
  
  Am J Pathol 177
  
  Pages: 698-712
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590346
[Journal Article] Transcriptional control of tight junction proteins via a protein kinase C signal pathway in human telomerase reverse transcriptase-transfected human pancreatic duct epithelial cells2010
- Author(s)
  Yamaguchi H, Kojima T, Ito T, Kimura Y, Imamura M, Son S, Koizumi J, Murata M, Nagayama M, Nobuoka T,Tanaka S,Hirata K, Sawada N
- Journal Title
  
  Am J Pathol
  
  Volume: 177 Issue: 2 Pages: 698-712
- DOI
  10.2353/ajpath.2010.091226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336
[Journal Article] PPARγ agonists upregulate the barrier function of tight junctions via a PKC pathway in human nasal epithelial cells2010
- Author(s)
  Ogasawara N, Kojima T, Go M, Ohkuni T, Koizumi J, Kamekura R, Masaki T, Murata M, Tanaka S,Fuchimoto J, Himi T, Sawada N
- Journal Title
  
  Pharmacol Res
  
  Volume: 61 Issue: 6 Pages: 489-498
- DOI
  10.1016/j.phrs.2010.03.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336
[Journal Article] Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-κB in dendritic cells.2010
- Author(s)
  Kamekura R, Kojima T, Takashima A, Koizumi JI, Ogasawara N, Go M, Takano KI, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N
- Journal Title
  
  Histochem Cell Biol 133
  
  Pages: 339-348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590346
[Journal Article] Thymic stromal lymphopoietin enhances tight junction barrier function of human nasal epithelial cells.2009
- Author(s)
  Kamekura R, Kojima T, Koizumi J, Ogasawara N, Kurose M, Go M, Harimaya A, Murata M, Tanaka S, Chiba H, Himi T, Sawada N
- Journal Title
  
  Cell Tissue Res 338
  
  Pages: 283-293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Induction of JAM-A during differentiation of human THP-1 dendritic cells.2009
- Author(s)
  Ogasawara N, Kojima T, Go M, Fuchimoto J, Kamekura R, Koizumi J, Ohkuni T, Masaki T, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N
- Journal Title
  
  Biochem Biophys Res Commun 389
  
  Pages: 543-549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590346
[Journal Article] Induction of JAM-A during differentiation of human THP-1 dendritic cells.2009
- Author(s)
  Ogasawara N, Kojima T, Go M, Fuchimoto J, Kamekura R, Koizumi J, Ohkuni T, Masaki T, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N
- Journal Title
  
  Biochem Biophys Res Commun 389
  
  Pages: 543-549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells.2009
- Author(s)
  Son S, Kojima T, Decaens C, Yamaguchi H, Ito T, Imamura M, Murata M, Tanaka S, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Histochem Cell Biol 131
  
  Pages: 411-424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Thymic stromal lymphopoietin enhances tight junction barrier function of human nasal epithelial cells.2009
- Author(s)
  Kamekura R, Kojima T, Koizumi J, Ogasawara N, Kurose M, Go M, Harimaya A, Murata M, Tanaka S, Chiba H, Himi T, Sawada N
- Journal Title
  
  Cell Tissue Res 338
  
  Pages: 283-293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590346
[Journal Article] Tight junction proteins and signal transduction pathways in hepatocytes.2009
- Author(s)
  Kojima T, Murata M, Yamamoto T, Lan M, Imamura M, Son S, Takano K-i, Yamaguchi H, Ito T, Tanaka S, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Histol Histopathol 24
  
  Pages: 1463-1472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590346
[Journal Article] Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells.2009
- Author(s)
  Son S, Kojima T, Decaens C, Yamaguchi H, Ito T, Imamura M, Murata M, Tanaka S, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Histochem Cell Biol 131
  
  Pages: 411-424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590346
[Journal Article] Tight junction proteins and signal transduction pathways in hepatocytes.2009
- Author(s)
  Kojima T, Murata M, Yamamoto T, Lan M, Imamura M, Son S, Takano K-i, Yamaguchi H, Ito T, Tanaka S, Chiba H, Hirata K, Sawada N
- Journal Title
  
  Histol Histopathol 24
  
  Pages: 1463-1472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro.2008
- Author(s)
  Takano K, Kojima T, Ogasawara N, Go M, Kikuchi S, Ninomiya T, Kurose M, Koizumi J, Kamekura R, Murata M, Tanaka S, Chiba H, Himi T, Sawada N
- Journal Title
  
  J Mol Histol 39(3)
  
  Pages: 265-273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590346
[Journal Article] Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro.2008
- Author(s)
  Takano K, Kojima T, Ogasawara N, Go M, Kikuchi S, Ninomiya T, Kurose M, Koizumi J, Kamekura R, Murata M, Tanaka S, Chiba H, Himi T, Sawada N
- Journal Title
  
  J Mol Histol 39
  
  Pages: 265-273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390103
[Journal Article] Protein kinase Calpha inhibitor protects against downregulation of claudin-1 during epithelial-mesenchymal transition of pancreatic cancer
- Author(s)
  Kyuno D, Kojima T, Yamaguchi H, Ito T, Kimura Y, Imamura M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N
- Journal Title
  
  Carcinogenesis
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590336
[Journal Article] Transcriptional regulation of claudin-18 via specific protein kinase C signaling pathways and modification of DNA-methylation in human pancreatic cancer cells.
- Author(s)
  Ito T, Kojima T, Yamaguchi H, Kyuno D, Kimura Y, Imamura M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N
- Journal Title
  
  J Cell Biochem in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590346
[Journal Article] An NF-κB signaling pathway via PKCδ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells.
- Author(s)
  Masaki T, Kojima T, Okabayashi T, Ogasawara N, Ohkuni T, Obata K, Takasawa A, Murata M, Tanaka S, Hirakawa S, Fuchimoto J, Ninomiya T, Fujii N, Tsutsumi H, Himi T, Sawada N
- Journal Title
  
  Mol Biol Cell in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590346
[Presentation] タイト結合膜蛋白occludinの膜貫通領域のジスルフィド結合はoccludin同士の相互作用やHIF-1を介した安定性に関与する2022
- Author(s)
  田中　敏
- Organizer
  第102回北海道医学大会病理分科会・第55回北海道病理談話会
- Data Source
  KAKENHI-PROJECT-20K07402
[Presentation] HIF-1はタイト結合膜蛋白occludinの膜貫通領域のジスルフィド結合を介してその安定性に関与する2022
- Author(s)
  田中敏
- Organizer
  第111回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-20K07402
[Presentation] タイト結合膜蛋白occludinの膜貫通領域のジスルフィド結合はoccludin同士の相互作用を調節し、HIF-1を介した安定性に関与する2022
- Author(s)
  田中　敏
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07402
[Presentation] タイト結合膜蛋白occludinは膜貫通領域にジスルフィド結合をもつが、細胞内分布には大きな変化を与えない2021
- Author(s)
  田中　敏
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07402
[Presentation] ジスルフィド結合とHIF-1は別々の経路でタイト結合膜蛋白occludinの低酸素での安定性に関与している2019
- Author(s)
  田中敏, 小野佑輔, 高澤啓, 小山内誠, 澤田典均
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08735
[Presentation] タイト結合膜蛋白occludinはジスルフィド結合とHIF-1、ユビキチン化により安定性が制御される2019
- Author(s)
  田中敏, 小野佑輔, 高澤啓, 村田雅樹, 小山内誠, 澤田典均
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17K08735
[Presentation] タイト結合膜蛋白occludinの安定性はジスルフィド結合とHIF-1やユビキチン化によって制御されている2018
- Author(s)
  田中敏, 小野佑輔, 高澤啓, 村田雅樹, 小山内誠, 澤田典均
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08735
[Presentation] タイト結合蛋白occludinはジスルフィド結合とユビキチン化を介して安定性が調節され、アポトーシス誘導を制御する2017
- Author(s)
  田中敏, 高澤啓, 村田雅樹, 小山内誠, 澤田典均
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08735
[Presentation] タイト結合蛋白occludinのジスルフィド結合はユビキチン化を介してその安定性や細胞増殖を調節する2017
- Author(s)
  田中敏, 高澤啓, 村田雅樹, 小山内誠, 澤田典均
- Organizer
  第106回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17K08735
[Presentation] タイト結合蛋白occludinのジスルフィド結合はユビキチン化を介してその安定性や細胞増殖を調節する2017
- Author(s)
  田中敏, 高澤啓, 村田雅樹, 小山内誠, 澤田典均
- Organizer
  第106回日本病理学会総会
- Place of Presentation
  京王プラザホテル　東京都新宿区
- Year and Date
  2017-04-27
- Data Source
  KAKENHI-PROJECT-26460455
[Presentation] タイト結合蛋白occludinのジスルフィド結合を介したユビキチン化は、その細胞内分布や安定性を調節し、細胞増殖に関与する2016
- Author(s)
  田中敏, 高澤啓, 村田雅樹, 高澤久美, 小山内誠, 澤田典均
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜　神奈川県横浜市
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26460455
[Presentation] 子宮頚部腺癌におけるタイト結合関連たんぱく質の免疫組織化学的検討2016
- Author(s)
  高澤　啓、秋元　太志、村田　雅樹、青山　智志、田中　敏、小山内　誠、長谷川　匡、澤田　典均
- Organizer
  日本病理学会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-26460421
[Presentation] 低酸素環境でのタイト結合蛋白Occludinの細胞内分布2015
- Author(s)
  田中敏、小野佑輔、平塚佑太郎、髙澤啓、村田雅樹、髙澤久美、田上洋平、真柄和史、澤田典均
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-26460455
[Presentation] タイト結合蛋白occludinの低酸素下でのジスルフィド結合とユビキチン化を介した細胞内分布調節2015
- Author(s)
  田中敏、小野佑輔、髙澤啓、村田雅樹、髙澤久美、小山内誠、澤田典均
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26460455
[Presentation] クローディン-6による細胞間接着は幹細胞の上皮分化を誘導する2012
- Author(s)
  杉本幸太郎、冨川直樹、金居李紗、田中敏、杉野隆、澤田典均、千葉英樹
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Year and Date
  2012-04-28
- Data Source
  KAKENHI-PROJECT-22590336
[Presentation] 肝炎および肝癌におけるタイト結合分子の発現変化2012
- Author(s)
  辻脇光洋、村田雅樹、高澤啓、平塚佑太郎、福田利英子、田中敏、小島隆、澤田典均
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Year and Date
  2012-04-27
- Data Source
  KAKENHI-PROJECT-22590336
[Presentation] 膵癌組織および膵癌細胞株におけるタイト結合分子tricellulin の核への局在2012
- Author(s)
  村田雅樹、小野佑輔、高澤啓、田中敏、小島隆、澤田典均
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Year and Date
  2012-04-27
- Data Source
  KAKENHI-PROJECT-22590336
[Presentation] 胆道癌における claudin-18、maspin の免疫組織化学的検討2012
- Author(s)
  高澤啓、計良淑子、村田雅樹、荻野次郎、及能大輔、田中敏、小島隆、長谷川匡、澤田典均
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Year and Date
  2012-04-28
- Data Source
  KAKENHI-PROJECT-22590336
[Presentation] タイト結合分子クローディンによる幹細胞の上皮分化誘導機構2011
- Author(s)
  杉本幸太郎、冨川直樹、田中敏、杉野隆、澤田典均、千葉英樹
- Organizer
  第100回日本病理学会総会
- Place of Presentation
  横浜
- Year and Date
  2011-04-28
- Data Source
  KAKENHI-PROJECT-22590336
[Presentation] 培養ヒト膵管上皮細胞における tricellulin 発現調節機構の解明 -Ca スイッチによる発現・局在変化を中心に2011
- Author(s)
  高澤啓、小島隆、及能大輔、辻脇光洋、村田雅樹、田中敏、澤田典均
- Organizer
  第100回日本病理学会総会
- Place of Presentation
  横浜
- Year and Date
  2011-04-28
- Data Source
  KAKENHI-PROJECT-22590336
[Presentation] 膵癌細胞株及び正常膵管上皮細胞におけるタイト結合と PKCa との関係2011
- Author(s)
  及能大輔、小島隆、伊東竜哉、山口洋志、辻脇光洋、高澤啓、村田雅樹、田中敏、澤田典均
- Organizer
  第100回日本病理学会総会
- Place of Presentation
  横浜
- Year and Date
  2011-04-28
- Data Source
  KAKENHI-PROJECT-22590336
[Presentation] 卵巣癌細胞株におけるタイト結合分子claudin-4 に対する CPE 作用条件についての検討2011
- Author(s)
  井上万梨絵、田中敏、染谷真行、高澤啓、村田雅樹、小島隆、斎藤豪、澤田典均
- Organizer
  第100回日本病理学会総会
- Place of Presentation
  横浜
- Year and Date
  2011-04-30
- Data Source
  KAKENHI-PROJECT-22590336
[Presentation] RSウイルス感染ヒト鼻粘膜上皮細胞におけるタイト結合の誘導2010
- Author(s)
  正木智之, 小島隆, 大國毅, 小笠原徳子, 氷見徹夫, 村田雅樹, 田中敏, 澤田典均
- Organizer
  第99回日本病理学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590346
[Presentation] 膵癌細胞株のPKCシグナル異常におけるタイト結合蛋白の変化.2009
- Author(s)
  伊東竜哉, 小島隆, 山口洋志, 村田雅樹, 田中敏, 千葉英樹, 平田公一, 澤田典均
- Organizer
  第98回日本病理学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 核内受容体PPAR-γを介したヒト鼻粘膜におけるタイト結合の発現調節機構2009
- Author(s)
  小笠原徳子, 小島隆, 郷充, 亀倉隆太, 大國毅, 正木智之, 村田雅樹, 田中敏, 千葉英樹, 氷見徹夫, 澤田典均
- Organizer
  第98回日本病理学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590346
[Presentation] 核内受容体PPAR-γを介したヒト鼻粘膜におけるタイト結合の発現調節機構.2009
- Author(s)
  小笠原徳子, 小島隆, 郷充, 亀倉隆太, 大國毅, 正木智之, 村田雅樹, 田中敏, 千葉英樹, 氷見徹夫, 澤田典均
- Organizer
  第98回日本病理学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19390103
[Presentation] 胆道癌におけるclaudin-18の発現と調節機構および機能解析
- Author(s)
  高澤啓、村田雅樹、計良淑子、田中敏、澤田典均
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島国際会議場
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-26460421
[Presentation] 低酸素環境でのタイト結合蛋白occludinの細胞内分布調節
- Author(s)
  田中敏、小野佑輔、平塚佑太郎、高澤啓、村田雅樹、高澤久美、田上洋平、真柄和史、澤田典均
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  愛知県名古屋市
- Year and Date
  2015-04-30 – 2015-05-02
- Data Source
  KAKENHI-PROJECT-26460455
[Presentation] 低酸素環境でのタイト結合膜蛋白occludinの分解に対するユビキチンの役割
- Author(s)
  田中敏、小野佑輔、平塚佑太郎、高澤啓、村田雅樹、高澤久美、澤田典均
- Organizer
  第60回日本病理学会秋季特別総会
- Place of Presentation
  沖縄県浦添市
- Year and Date
  2014-11-20 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-26460455
[Presentation] タイト結合蛋白occludinのジスルフィド結合を介した安定性調節機構
- Author(s)
  田中敏、小野佑輔、平塚佑太郎、高澤啓、村田雅樹、高澤久美、澤田典均
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26460455

1. MURATA Masaki (10404592)

# of Collaborated Projects: 4 results

# of Collaborated Products: 31 results
2. SAWADA Norimasa (30154149)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. KOJIMA Takashi (30260764)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
4. TAKASAWA Akira (00593021)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. CHIBA Hideki (00295346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. MASAKI Tomoyuki (30457717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. GO Mitsuru (80448604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. IMAMURA Masafumi (00404608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 小笠原徳子 (00438061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
10. 山口洋志 (80457704)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. OSANAI Makoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 沢田典均

# of Collaborated Projects: 0 results

# of Collaborated Products: 18 results

Tanaka Satoshi 田中 敏

TANAKA Satoshi 田中 敏

Research Projects

Research Products

Co-Researchers

ジスルフィド結合を介したタイト結合の機能解明：酸化還元環境と細胞増殖の関連Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The regulation of tight junction function via disulfide bond formation as a redox signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Tight junction regulates cell proliferation via disulfide bond formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The function of disulfide bond in tight junction protein, as an oxidative sensorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of potential clinical application of tight junction proteins in cervical adenocarcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Patho-physiology of the tight junction-mainly focusing on human normal epithelial cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analyses of tight junction formation via disulfide bondPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of human nasal mucosal barrier by tight junctions via innate immunity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathobiology of the tight junction : from cell biology of paracellular pathway to bed-side

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 細胞間結合装置.病気の分子形態学2011

Author(s)

Total Pages

Publisher

Data Source

[Book] 細胞間結合装置、日本臨床分子形態学会編、病気の分子形態学、学際企画2011

Author(s)

Data Source

[Journal Article] Cytotoxicity of Clostridium perfringens enterotoxin depends on the conditions of claudin-4 in ovarian carcinoma cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of the expression and localization of tight junction transmembrane proteins, claudin-1, -4, -7, occludin and JAM-A, in human cervical adenocarcinoma.2016

Author(s)

Journal Title

Data Source

[Journal Article] Nuclear localization of tricellulin promotes the oncogenic property of pancreatic cancer2016

Author(s)

Journal Title

DOI

Tanaka Satoshi 田中敏

TANAKA Satoshi 田中敏