MIZUSHIMA Hiroto 水島寛人

Researcher Number	30379094
Other IDs
Affiliation (Current)	2023: 大阪大学, 微生物病研究所, 特任講師(常勤)
Affiliation (based on the past Project Information) *help	2016: 大阪大学, 微生物病研究所, 助教 2011 – 2014: 大阪大学, 微生物病研究所, 助教 2009: 大阪大学, 微生物病研究所, 助教 2007: Osaka University, Research Institute for Microbial Disease, Assistant Professor 2004 – 2006: 大阪大学, 微生物病研究所, 助手
Review Section/Research Field	Principal Investigator Cell biology Except Principal Investigator Cell biology / Biological Sciences / Tumor therapeutics
Keywords	Principal Investigator 増殖因子 / 細胞接着 / 細胞増殖 / 細胞骨格 Except Principal Investigator HB-EGF / EGFR / 細胞増殖因子 / siRNA / ADAM / エクトドメインシェディング … More / ectodomain shedding / 3次元増殖 / EGF / インテグリン / 腫瘍形成 / 細胞外マトリックス / sHRNA / CRM197 / 癌間質 / 3次元環境 / EGFファミリー / 増殖機構 / エクトドメインシェディン / プロテアーゼ / シグナル伝達 / protease / DNAアレイ / シェディング / レンチウィルス / SiRNA / DNA aray / ErbB4 / 増殖抑制 / EGF受容体 / マイコプラズマ Less

Development of a novel anti-cancer therapeutics targeting HB-EGF
- Principal Investigator
  
  MEKADA EISUKE
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Osaka University
Integration and regulatory mechanism for growth factor and cell adhesion signalsPrincipal Investigator
- Principal Investigator
  
  MIZUSHIMA Hiroto
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
Identification of genes involved in the ectodomain sheddingof HB-EGF
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
Cell function regulation by membrane-anchored growth factors
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Analysis of the ectodomain shedding mechanism of HB-EGF
- Principal Investigator
  
  MEKADA Eisuke
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University

All 2017 2015 2014 2013 2012 2011 2010 2009 2007 2006 2005 Other

All Journal Article Presentation

[Journal Article] ErbB1 and ErbB4 generate opposing signals regulating mesenchymal cell proliferation during valvulogenesis.2017
- Author(s)
  Iwamoto R, Mine N, Mizushima H, Mekada E
- Journal Title
  
  J. Cell Sci.
  
  Volume: 130 Pages: 1321-1332
- DOI
  10.1242/jcs.196618
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26250033, KAKENHI-PROJECT-15K07046
[Journal Article] Identification of diphtheria toxin R domain mutants with enhanced inhibitory activity against HB-EGF.2015
- Author(s)
  Suzuki K, Mizushima H, Abe H, Iwamoto R, Nakamura H, Mekada E
- Journal Title
  
  J Biochem.
  
  Volume: mvu079 Pages: 1-13
- DOI
  10.1093/jb/mvu079
- NAID
  40020461422
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23570227, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118008, KAKENHI-PROJECT-26460525, KAKENHI-PROJECT-15K07046, KAKENHI-PROJECT-24570212, KAKENHI-PROJECT-26250033
[Journal Article] HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers2011
- Author(s)
  Murata T, Mizushima H, Chinen I, Moribe H, Yagi S, Hoffman RM, Kimura T, Yoshino K, Ueda Y, Enomoto T, Mekada E.
- Journal Title
  
  Cancer Res.
  
  Volume: 71 (21) Pages: 6633-6642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570227
[Journal Article] Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells.2011
- Author(s)
  Koshikawa,N., Mizushima,H., Minegishi,T., Eguchi,F., Yotsumoto,F., Nabeshima,K. Miyamoto,S., Mekada,E., Seiki,M
- Journal Title
  
  Cancer Sci. 102
  
  Pages: 111-116
- NAID
  10029288679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] MT1-MMP cleaves off the NH2-terminal portion of HB-EGF and converts it into a heparin -independent growth factor.2010
- Author(s)
  Koshikawa,N., Mizushima,H., Minegishi,T., Iwamoto,R., Mekada,E. Seiki,M
- Journal Title
  
  Cancer Res. 70
  
  Pages: 6093-6103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.2009
- Author(s)
  Mizushima,H., Wang,X., Miyamoto,S., Mekada,E.
- Journal Title
  
  J. Cell Sci. 122
  
  Pages: 4277-4286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.2009
- Author(s)
  Mizushima, H., Wang, X., Miyamoto, S., Mekada, E.
- Journal Title
  
  J.Cell Sci. 122
  
  Pages: 4277-4286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.2009
- Author(s)
  Mizushima, H., Wang, X., Miyamoto, S., Mekada, E.
- Journal Title
  
  J.Cell Sci.
  
  Volume: 122 Pages: 4277-4286
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity.2007
- Author(s)
  Kageyama,T., Ohishi,M., Miyamoto,S., Mizushima,H., Iwamoto,R. Mekada,E
- Journal Title
  
  J.Biochem. 142
  
  Pages: 95-104
- NAID
  10020098014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity2007
- Author(s)
  Kageyama, T., Ohishi, M., Miyamoto, S., Mizushima, H., Iwamoto, R., Mekada, E
- Journal Title
  
  J. Biochem 142
  
  Pages: 95-104
- NAID
  10020098014
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370079
[Journal Article] Cytoplasmic Domain Phosphorylation of Heparin-Binding EGF-like Growth Factor.2006
- Author(s)
  Wang,X., Mizushima,H., Adachi,S., Ohishi,M., Iwamoto,R., Mekada,E.
- Journal Title
  
  Cell Struct. Funct. 31
  
  Pages: 15-27
- NAID
  130004053854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts.2006
- Author(s)
  Kakumoto, K., Sasai, K., Sukezane, T., Oneyama, C., Ishimaru, S., Shibutani, K., Mizushima, H., Mekada, E., Hanafusa, H., Akagi, T.
- Journal Title
  
  Proc.Natl.Acad.Sci. USA103
  
  Pages: 5490-5495
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Cytoplasmic Domain Phosphorylation of Heparon-Binding EGF-like Growth Factor.2006
- Author(s)
  Wang, X., Mizushima, H., Adachi, S., Ohishi, M., Iwamoto, R., Mekada,E.
- Journal Title
  
  Cell Struct.Funct. 31
  
  Pages: 15-27
- Data Source
  KAKENHI-PROJECT-18370079
[Journal Article] FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts.2006
- Author(s)
  Kakumoto,K., Sasai,K., Sukezane,T., Oneyama,C., Ishimaru,S., Shibutani,K., Mizushima,H., Mekada E., Hanafusa,H. Akagi,T
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 103
  
  Pages: 5490-5495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Cytoplasmic Domain Phosphorylation of Heparon-Binding EGF-like Growth Factor.2006
- Author(s)
  Wang, X., Mizushima, H., Adachi, S., Ohishi, M., Iwamoto, R., Mekada,E.
- Journal Title
  
  Cell Struct.Funct. 31
  
  Pages: 15-27
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] Cytoplasmic Domain Phosphorylation of Heparin-Binding EGF-like Growth Factor.2006
- Author(s)
  Wang, X., Mizushima, H., Adachi, S., Oishi, M., Iwamoto, R., Mekada, E.
- Journal Title
  
  Cell Struct.Funct. (in press.)
- NAID
  130004053854
- Data Source
  KAKENHI-PROJECT-16207014
[Journal Article] Cytoplasmic Domain Phosphorylation of Heparin-Binding EGF-like Growth Factor.2006
- Author(s)
  Wang, X., Mizushima, H., Adachi, S., Oishi, M., Iwamoto, R., Mekada, E.
- Journal Title
  
  Cell Struct.Funct. (in press)
- NAID
  130004053854
- Data Source
  KAKENHI-PROJECT-17014057
[Journal Article] FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts.2006
- Author(s)
  Kakumoto, K., Sasai, K., Sukezane, T., Oneyama, C., Ishimaru, S., Shibutani, K., Mizushima, H., Mekada, E., Hanafusa, H., Akagi,T.
- Journal Title
  
  Proc.Natl.Acad.Sci. USA103
  
  Pages: 5490-5495
- Data Source
  KAKENHI-PROJECT-18370079
[Journal Article] Clinical significance of heparin-binding EGF (epidermal growth factor)-like growth factor and ADAM (a disintegrin and metalloprotease) 17 expression in human ovarian cancer.2005
- Author(s)
  Tanaka, T., Miyamoto, S., Suzuki, S.O., Oki, E., Yagi, H., Sonoda, K., Yamazaki, A., Mizushima, H., Maehara, Y., Mekada, E., Nakano, H.
- Journal Title
  
  Clin.Cancer Res. 11
  
  Pages: 4783-4792
- Data Source
  KAKENHI-PROJECT-16207014
[Journal Article] Clinical significance of heparin-binding EGF (epidermal growth factor)-like growth factor and ADAM (a disintegrin and metalloprotease) 17 expression in human ovarian cancer.2005
- Author(s)
  Tanaka, T., Miyamoto, S., Suzuki, S.O., Oki, E., Yagi, H., Sonoda, K., Yamazaki, A., Mizushima, H., Maehara, Y., Mekada, E., Nakano, H.
- Journal Title
  
  Clin.Cancer Res. 11
  
  Pages: 4783-4792
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] FAKリン酸化によるHB-EGF依存的細胞増殖制御2014
- Author(s)
  水島寛人、船越敍希、目加田英輔
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良
- Year and Date
  2014-06-11
- Data Source
  KAKENHI-PROJECT-26250033
[Presentation] Sequestration of FAK on microtubule negatively regulates HB-EGF-dependent cell growth2013
- Author(s)
  Hiroto Mizushima, Mitsuki Funakoshi, Eisuke Mekada
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  ウインクあいち（愛知県産業労働センター）
- Data Source
  KAKENHI-PROJECT-23570227
[Presentation] HB-EGF and PDGF Mediate Reciprocal Interactions of Carcinoma Cells with Cancer-Associated Fibroblasts to Support Progression of Uterine Cervical Cancers2012
- Author(s)
  Hiroto Mizushima, Takuya Murata, Ichino Chinen, Hiroki Moribe, Shigeo Yagi, Robert M Hoffman, Tadashi Kimura, Kiyoshi Yoshino, Yutaka Ueda, Takayuki Enomoto, Eisuke Mekada
- Organizer
  第４５回日本発生学会、第６４回日本細胞生物学会合同大会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-23570227
[Presentation] インテグリンシグナルはEGFファミリー増殖因子の増殖因子活性を単層培養において不顕在化する2009
- Author(s)
  水島寛人、宮本新吾、目加田英輔
- Organizer
  第61回日本細胞生物学会大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-17014057
[Presentation] Regulation of HB-EGF-dependent cell growth by phosphorylation of FERM domain of FAK
- Author(s)
  Hiroto Mizushima, Mitsuki Funakoshi, Eisuke Mekada
- Organizer
  第６３回日本細胞生物学会大会
- Place of Presentation
  北海道大学クラーク会館、学術交流会館（北海道）
- Data Source
  KAKENHI-PROJECT-23570227
[Presentation] FAKリン酸化によるHB-EGF依存的細胞増殖制御
- Author(s)
  水島寛人、船越敍希、目加田英輔
- Organizer
  第６６回日本細胞生物学会大会
- Place of Presentation
  奈良県新公会堂
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-23570227

1. MEKADA Eisuke (20135742)

# of Collaborated Projects: 5 results

# of Collaborated Products: 26 results
2. IWAMOTO Ryo (10213323)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. ASANO Shiro (00397613)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NAKAMURA Kuniaki (70311305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAKAMURA Takashi (00570673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. YONEDA Tomoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ABE Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 中村春木

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIZUSHIMA Hiroto 水島 寛人

Research Projects

Research Products

Co-Researchers

Development of a novel anti-cancer therapeutics targeting HB-EGF

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Integration and regulatory mechanism for growth factor and cell adhesion signalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of genes involved in the ectodomain sheddingof HB-EGF

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cell function regulation by membrane-anchored growth factors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the ectodomain shedding mechanism of HB-EGF

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] ErbB1 and ErbB4 generate opposing signals regulating mesenchymal cell proliferation during valvulogenesis.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of diphtheria toxin R domain mutants with enhanced inhibitory activity against HB-EGF.2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers2011

Author(s)

Journal Title

Data Source

[Journal Article] Proteolytic activation of heparin-binding EGF-like growth factor by membrane-type matrix metalloproteinase-1 in ovarian carcinoma cells.2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] MT1-MMP cleaves off the NH2-terminal portion of HB-EGF and converts it into a heparin -independent growth factor.2010

Author(s)

Journal Title

Data Source

[Journal Article] Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.2009

Author(s)

Journal Title

Data Source

[Journal Article] Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.2009

Author(s)

Journal Title

Data Source

[Journal Article] Integrin signal masks growth-promotion activity of HB-EGF in monolayer cell cultures.2009

Author(s)

Journal Title

Data Source

[Journal Article] Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity.2007

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity2007

Author(s)

Journal Title

NAID

Description

MIZUSHIMA Hiroto 水島寛人