KIMURA Hirotaka 木村洋貴

Researcher Number	30382899
Affiliation (based on the past Project Information) *help	2016: 秋田大学, 学内共同利用施設等, 特任助教 2016: 秋田大学, 生体情報研究センター, 特任助教 2014 – 2015: 秋田大学, 学内共同利用施設等, 助教 2013: 秋田大学, 医学(系)研究科(研究院), 非常勤講師 2013: 秋田大学, 大学院医学系研究科, 非常勤講師 2012: 秋田大学, 医学(系)研究科(研究院), その他
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Collagenous pathology/Allergology Except Principal Investigator Biological pharmacy
Keywords	Principal Investigator PIK3C3 / 心肥大 / 心不全 / 心筋症 / ユビキチン化 / Vps34 / Pik3c3 / 顕微鏡的多発血管炎 / Myotubularin / イノシトールリン脂質 … More / 好中球細胞外トラップ / MTMRファミリー / myotubularin / NETs … More Except Principal Investigator 血管炎 / リン脂質 / 好中球 / 顕微鏡的多発血管炎 / 病態モデル Less

Development of a mouse model of microscopic polyangiitis
- Principal Investigator
  
  Sasaki Takehiko
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Akita University
The role of myotubularins in pathogenesis of microscopic polyangiitis.Principal Investigator
- Principal Investigator
  
  Kimura Hirotaka
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Akita University
The roles of class III PI3K in cardiomyocytesPrincipal Investigator
- Principal Investigator
  
  KIMURA Hirotaka
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Akita University

All 2017 2015 2013

All Journal Article Presentation Book

[Book] イノシトールリン脂質と炎症・免疫の制御2017
- Author(s)
  木村洋貴，佐々木雄彦
- Total Pages
  10
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-26461458
[Book] 最新生理活性脂質研究とその臨床・創薬応用研究（仮題）遺伝子医学 MOOK 24号2013
- Author(s)
  木村洋貴，小藤智史，佐々木雄彦
- Publisher
  メディカル　ドゥ
- Data Source
  KAKENHI-PROJECT-24790734
[Journal Article] Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy2017
- Author(s)
  Kimura H, Eguchi S, Sasaki J, Kuba K, Nakanishi H, Takasuga S, Yamazaki M, Goto A, Watanabe H, Itoh H, Imai Y, Suzuki A, Mizushima N, Sasaki T
- Journal Title
  
  JCI insight
  
  Volume: 2 Pages: 89462-89478
- DOI
  10.1172/jci.insight.89462
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05978, KAKENHI-PLANNED-26114005, KAKENHI-PROJECT-26253083, KAKENHI-PROJECT-15H04693, KAKENHI-PROJECT-26293050, KAKENHI-PROJECT-26460059, KAKENHI-PROJECT-26461458, KAKENHI-PROJECT-15K14947, KAKENHI-PROJECT-15K15304, KAKENHI-PLANNED-25111005, KAKENHI-PROJECT-26440020, KAKENHI-PROJECT-26670132, KAKENHI-PROJECT-15K18857, KAKENHI-PROJECT-17H01400, KAKENHI-PROJECT-26253006, KAKENHI-PROJECT-26640081, KAKENHI-PLANNED-15H05899, KAKENHI-PROJECT-17H03980
[Journal Article] INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor.2015
- Author(s)
  Kofuji S, Kimura H, Nakanishi H, Nanjo H, Takasuga S, Liu H, Eguchi S, Nakamura R, Itoh R, Ueno N, Asanuma K, Huang M, Koizumi A, Habuchi T, Yamazaki M, Suzuki A, Sasaki J, Sasaki T
- Journal Title
  
  Cancer Discov.
  
  Volume: in press Pages: 730-739
- DOI
  10.1158/2159-8290.cd-14-1329
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26253006, KAKENHI-PROJECT-26440020, KAKENHI-PROJECT-26461458, KAKENHI-PROJECT-15K14947, KAKENHI-PROJECT-26670695, KAKENHI-PROJECT-15K18857, KAKENHI-PLANNED-15H05899, KAKENHI-PROJECT-26860686, KAKENHI-PROJECT-25293332
[Journal Article] 3) Deletion of Autophagy-related 5 (Atg5) and Pik3c3 Genes in the Lens Causes Cataract Independent of Programmed Organelle Degradation2013
- Author(s)
  森下英晃、江口賢史、木村洋貴、佐々木純子、酒巻有里子、Robinson ML、佐々木雄彦、水島昇
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Pages: 11436-11447
- DOI
  10.1074/jbc.m112.437103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J05229, KAKENHI-PROJECT-24390067, KAKENHI-PROJECT-24770115, KAKENHI-PROJECT-24790734, KAKENHI-PUBLICLY-25117704
[Journal Article] Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine.2013
- Author(s)
  Takasuga , Wada et al.
- Journal Title
  
  Proc. Natl. Acad. Sci. U S A
  
  Volume: 1726-1731 Pages: 1726-1731
- DOI
  10.1073/pnas.1213212110
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21116002, KAKENHI-PROJECT-21390050, KAKENHI-PROJECT-23229001, KAKENHI-PROJECT-23701036, KAKENHI-PROJECT-24240120, KAKENHI-PROJECT-24390046, KAKENHI-PROJECT-24390067, KAKENHI-PROJECT-24590930, KAKENHI-PROJECT-24657081, KAKENHI-PROJECT-24659084, KAKENHI-PROJECT-24659124, KAKENHI-PROJECT-24770115, KAKENHI-PROJECT-24790734, KAKENHI-PUBLICLY-25113517, KAKENHI-PROJECT-25650066, KAKENHI-PUBLICLY-23113706, KAKENHI-PUBLICLY-23113716, KAKENHI-PUBLICLY-23121505, KAKENHI-PUBLICLY-24112515
[Presentation] Phosphatidylinositol 3-phosphate によるNETs 形成制御機構と顕微鏡的多発血管炎の発症病態の検討2017
- Author(s)
  木村洋貴
- Organizer
  群馬大学・秋田大学　第5回生体情報研究シンポジウム
- Place of Presentation
  秋田大学医学部本道会館2階
- Invited
- Data Source
  KAKENHI-PROJECT-26461458
[Presentation] The class III phosphoinositide 3-kinase, Vps34 plays a critical role in pathogenesis of cardiac hypertrophy in human by regulating degradation of proteins via ESCRT.2015
- Author(s)
  木村洋貴，江口賢史，久場敬司，今井由美子，高須賀俊輔，伊藤玲悦，中村亮太郎，中西広樹，石川将己，佐々木純子，山﨑正和，佐々木雄彦
- Organizer
  第38回日本分子生物学会／第88回生化学会
- Place of Presentation
  神戸ポートピアホテル
- Year and Date
  2015-12-03
- Invited
- Data Source
  KAKENHI-PROJECT-26461458
[Presentation] 心肥大におけるホスホイノシタイド代謝酵素Vps34のタンパク質分解機構の役割2015
- Author(s)
  木村洋貴、江口賢史、久場敬司、今井由美子、高須賀俊輔、伊藤玲悦、中村亮太郎、中西広樹、石川将己、佐々木純子、山崎正和、佐々木雄彦
- Organizer
  第38回日本分子生物学会年会・第88回生化学会大会　合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-03
- Invited
- Data Source
  KAKENHI-PROJECT-15K14947
[Presentation] 心筋でのホスホイノシタイド代謝酵素の機能解析2013
- Author(s)
  木村洋貴,江口賢史,久場敬司,小藤智史,高須賀俊輔,中村亮太郎,浅沼研,鮎川友紀,佐々木純子,山﨑正和,佐々木雄彦
- Organizer
  第2回生体情報研究シンポジウム
- Place of Presentation
  群馬大学生体情報研究所
- Year and Date
  2013-06-14
- Data Source
  KAKENHI-PROJECT-24790734
[Presentation] 心筋でのホスホイノシタイド代謝酵素Vps34の機能解析2013
- Author(s)
  木村洋貴,江口賢史,久場敬司,今井由美子,小藤智史,高須賀俊輔,浅沼研,伊藤玲悦,中村亮太郎,鮎川友紀,佐々木純子,山﨑正和,佐々木雄彦
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸国際展示場
- Year and Date
  2013-12-04
- Data Source
  KAKENHI-PROJECT-24790734
[Presentation] 脂質キナーゼPIK3C3欠損による自己免疫疾患2013
- Author(s)
  江口賢史，木村洋貴，浅沼研，堀江泰夫，佐々木純子，佐々木雄彦
- Organizer
  第11回北東北血液研究会
- Place of Presentation
  秋田市
- Data Source
  KAKENHI-PROJECT-24790734
[Presentation] 心筋でのホスホイノシタイド代謝酵素の機能解析2013
- Author(s)
  木村洋貴，江口賢史，久場敬司，小藤智史，高須賀俊輔，中村亮太郎，浅沼研，鮎川友紀，佐々木純子，山﨑正和，佐々木雄彦
- Organizer
  第2回生体情報研究シンポジウム
- Place of Presentation
  群馬大学　生体調節研究所
- Data Source
  KAKENHI-PROJECT-24790734

1. Kofuji Satoshi (00508153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. Sasaki Junko (30333371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. Sasaki Takehiko (50333365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. EGUCHI Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
5. NAKANISHI Hiroki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. KUBA Keiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. HORIE Yasuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. HUANG Mingguo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 森下英晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
10. 今井由美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 鈴木聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 後藤裕樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 高須賀俊輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
14. 水島昇

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 和田洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 大西洋英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 羽渕友則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 南條博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KIMURA Hirotaka 木村 洋貴

Research Projects

Research Products

Co-Researchers

Development of a mouse model of microscopic polyangiitis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of myotubularins in pathogenesis of microscopic polyangiitis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The roles of class III PI3K in cardiomyocytesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] イノシトールリン脂質と炎症・免疫の制御2017

Author(s)

Total Pages

Publisher

Data Source

[Book] 最新生理活性脂質研究とその臨床・創薬応用研究（仮題） 遺伝子医学 MOOK 24号2013

Author(s)

Publisher

Data Source

[Journal Article] Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 3) Deletion of Autophagy-related 5 (Atg5) and Pik3c3 Genes in the Lens Causes Cataract Independent of Programmed Organelle Degradation2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] Phosphatidylinositol 3-phosphate によるNETs 形成制御機構と顕微鏡的多発血管炎の発症病態の検討2017

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] The class III phosphoinositide 3-kinase, Vps34 plays a critical role in pathogenesis of cardiac hypertrophy in human by regulating degradation of proteins via ESCRT.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 心肥大におけるホスホイノシタイド代謝酵素Vps34のタンパク質分解機構の役割2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 心筋でのホスホイノシタイド代謝酵素の機能解析2013

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 心筋でのホスホイノシタイド代謝酵素Vps34の機能解析2013

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

KIMURA Hirotaka 木村洋貴

[Book] 最新生理活性脂質研究とその臨床・創薬応用研究（仮題）遺伝子医学 MOOK 24号2013