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KUROKI RYOTA  黒木 良太

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… Alternative Names

KUROKI Ryota  黒木 良太

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Researcher Number 30391246
External Links
Affiliation (based on the past Project Information) *help 2017: 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, ユニット長
2015: 国立研究開発法人日本原子力研究開発機構, その他部局等, 研究員
2015: 国立研究開発法人日本原子力研究開発機構, 原子力科学研究部門 量子ビーム応用研究センター, 研究主席
2014: 独立行政法人日本原子力研究開発機構, 原子力科学研究部門 量子ビーム応用研究センター, 研究主席
2014: 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, ユニット長 … More
2007 – 2012: Japan Atomic Energy Agency, 量子ビーム応用研究部門, 研究主席
2009 – 2011: 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, ユニット長
2009: 独立行政法人 日本原子力研究開発機構, 量子ビーム応用研究部門, 研究主席
2009: Japan Atomic Energy Agency, 量子ビーム応用研究部門, 研究主席
2006 – 2007: 独立行政法人日本原子力研究開発機構, 研究主幹
2005 – 2006: 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, 研究主幹 Less
Review Section/Research Field
Principal Investigator
Living organism molecular science / Physical pharmacy / Transition State Control / Structural biochemistry
Except Principal Investigator
Chemistry related to living body / Applied microbiology / Drug development chemistry / Structural biochemistry / Bio-related chemistry
Keywords
Principal Investigator
水和水 / タンパク質 / 中性子回折 / 水素原子 / 結晶構造 / 創薬標的タンパク質 / 熱測定 / 脱水和 / シミュレーション / 薬物設計 … More / 創薬標的分子 / 中性子解析 / 創薬標的 / 阻害剤 / 分子設計 / 蛋白質 / 分子認識 / 水和 / 分子間架橋 / T4リゾチーム / 水和構造 / disulfide bond / T4 phage lysozyme / x-ray crystallography / protein engineering / サイトカイン受容体 / 相互作用 / 構造生物学 / 血液学 / 動物細胞発現 / 活性化機構 / 変異導入 / 細胞増殖 / 血小板 / 巨核球 / X線結晶構造解析 … More
Except Principal Investigator
翻訳後修飾 / 水和反応 / 酵素反応 / 時間分割構造解析 / 構造生物学 / X線結晶構造解析 / 時間分割結晶構造解析 / 反応中間体 / 中性子構造解析 / 放射線 / 遺伝子 / 微生物 / タンパク質 / DNA修復 / 加水分解 / 結晶構造解析 / タンパク質成熟化 / アクセサリータンパク質 / 中性子 / 生物・生体工学 / バイオリアクター / 医薬分子機能学 / 抗体 / 低分子化抗体 / T7ファージ / ファージ提示法 / 安定性 / システインスルフェン酸 / 触媒機構 / 結晶構造 / 酵素触媒機構 / 金属酵素 / 酵素反応機構 / 時分割結晶構造解析 / 顆粒球コロニー刺激因子 / 受容体活性化機構 / Granulocyte Colony-Stimulating Factor / Activation Mechanism of Receptor / X-ray Crystallography / 触媒反応機構 / 顕微分光法 / SFX / XFEL / 質量分析 / FTIR Less
  • Research Projects

    (12 results)
  • Research Products

    (96 results)
  • Co-Researchers

    (19 People)
  •  遷移状態の制御を目指した酵素反応中間体の捕捉と中性子構造解析Principal Investigator

    • Principal Investigator
      黒木 良太
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Transition State Control
    • Research Institution
      Japan Atomic Energy Agency
  •  Uncovering the catalytic mechanism of nitrile hydratase based on the structure of the novel cyclic reaction intermediate

    • Principal Investigator
      ODAKA MASAFUMI
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bio-related chemistry
    • Research Institution
      Akita University
  •  巨核球の増殖分化を担うトロンボポエチン受容体の活性化機構の分子構造基盤Principal Investigator

    • Principal Investigator
      黒木 良太
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      Japan Atomic Energy Agency
  •  Elucidation of catalytic mechanisms as well as subunit-assembly of nitrile hydratase family enzymes by using advanced structural studies

    • Principal Investigator
      ODAKA Masafumi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemistry related to living body
    • Research Institution
      Akita University
      Tokyo University of Agriculture and Technology
  •  Elucidation of Protein-Ligand Interactions Using Neutron DiffractionPrincipal Investigator

    • Principal Investigator
      KUROKI Ryota
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Physical pharmacy
    • Research Institution
      Japan Atomic Energy Agency
  •  Elucidation of mechanisms for catalytic center maturation and catalysis of nitrile hydratase family enzyme

    • Principal Investigator
      ODAKA Masafumi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemistry related to living body
    • Research Institution
      Tokyo University of Agriculture and Technology
  •  Construction of human antibody library and establishment of selection method to develop fragment antibody therapeutics

    • Principal Investigator
      ITO Yuji
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      Kagoshima University
  •  Technological improvement for Neutron Crystallographic Analysis of Protein StructuresPrincipal Investigator

    • Principal Investigator
      KUROKI Ryota
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Structural biochemistry
    • Research Institution
      Japan Atomic Energy Agency
  •  Elucidation of the binding mode of DNA repair promoting protein to strand breaks

    • Principal Investigator
      NARUMI Issay
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied microbiology
    • Research Institution
      Japan Atomic Energy Agency
  •  生体高分子の機能発現における水素・水和水の静的・動的な役割の実証Principal Investigator

    • Principal Investigator
      黒木 良太
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Living organism molecular science
    • Research Institution
      Japan Atomic Energy Agency
  •  Creation of the Intermolecular Disulfide Bonded Crystal to Observe Tertiary Structures in Different Solvent ConditionsPrincipal Investigator

    • Principal Investigator
      KUROKI Ryota
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Living organism molecular science
    • Research Institution
      Quantum Beam Science Directorate, Japan Atomic Energy Agency
  •  Elucidation of Activation Mechanism of Granulocyte Colony-Stimulating Factor Receptor

    • Principal Investigator
      TAMADA Taro
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      Japan Atomic Energy Agency

All 2015 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book Patent

  • [Book] 「医療関連酵素」、酵素利用技術体系(小宮山眞監修)2010

    • Author(s)
      安達基泰、角南智子、黒木良太
    • Publisher
      エヌ・ティー・エス
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Book] II-第2章「中性子」、タンパク質結晶の新展開(高野和文監修)2008

    • Author(s)
      大原高志、玉田太郎、栗原和男、黒木良太
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Book] 『たんぱく質結晶の新展開』第2編第6章抗体を用いた結晶化、第3編第2章中性子2008

    • Author(s)
      黒木良太(分担執筆)
    • Total Pages
      16
    • Publisher
      (株)シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Book] I-第6章「抗体を用いた結晶化」、タンパク質結晶の新展開(高野和文監修)2008

    • Author(s)
      玉田太郎、新井栄揮、本庄栄二郎、黒木良太
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Book] 「中性子解析」, 生命科学のための機器分析ハンドブック(西村善文編)2007

    • Author(s)
      黒木良太、安達基泰、栗原和男、玉田太郎
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Book] 「組換えタンパク質の発現と精製のコツ」、タンパク質精製と取り扱いのコツ(森山達哉編)2007

    • Author(s)
      本庄栄二郎、黒木良太
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Book] タンパク質の発現系(タンパク質科学イラストレーテッド(竹縄忠臣 編))2005

    • Author(s)
      本庄栄二郎, 黒木良太(分担)
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17510186
  • [Journal Article] トロンボポエチンとトロンボポエチン受容体の構造と作用2015

    • Author(s)
      黒木良太、宮崎洋、加藤尚志
    • Journal Title

      血液フロンティア

      Volume: 25 Pages: 21-30

    • Data Source
      KAKENHI-PROJECT-26293009
  • [Journal Article] Neutron and X-ray crystallographic analysis of the human α-thrombin-bivalirudin complex at pD 5.0 : Protonation states and hydration structure of the enzyme-product complex.2013

    • Author(s)
      Yamada T, Kurihara K, Ohnishi Y, Tamada T, Tomoyori K, Masumi K, Tanaka I, Kuroki R, Niimura N
    • Journal Title

      Biochim Biophys Acta.

    • Data Source
      KAKENHI-PROJECT-22390010
  • [Journal Article] A structural mechanism for dimeric to tetrameric oligomer conversion in Halomonas sp.nucleoside diphosphate kinase2012

    • Author(s)
      Arai S, Yonezawa Y, Okazaki N, Matsumoto F, Tamada T, Tokunaga H, Ishibashi M, Blaber M, Tokunaga M, Kuroki R
    • Journal Title

      Protein Science

      Volume: 287 Pages: 498-510

    • DOI

      10.1002/pro.2032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Journal Article] Seven cysteine- deficient mutants depict the interplay between thermal and chemical stabilities of individual cysteine residues in mitogen-activated protein kinase c-Jun N-terminal kinase 1.2012

    • Author(s)
      Nakaniwa T, Fukada H, Inoue T, Gouda M, Nakai R, Kirii Y, Adachi M, Tamada T, Segawa S, Kuroki R, Tada T, Kinoshita T
    • Journal Title

      Biochemistry

      Volume: 51 Pages: 8410-8421

    • DOI

      10.1021/bi300918w

    • Data Source
      KAKENHI-PROJECT-22390010
  • [Journal Article] Structure and function of ∆1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa.2012

    • Author(s)
      Shoyama Y, Tamada T, Kurihara K, Takeuchi A, Taura F, Arai S, Blaber M, Shoyama Y, Morimoto S, Kuroki R
    • Journal Title

      Journal of Molecular Biology

      Volume: 423 Pages: 96-105

    • DOI

      10.1016/j.jmb.2012.06.030

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Journal Article] Crystallization and preliminary neutron diffraction studies of ADP-ribose pyrophosphatase-I from Thermus thermophilus HB8.2012

    • Author(s)
      Nobuo Okazaki, Motoyasu Adachi, Taro Tamada, Kazuo Kurihara, Takushi Ooga, Nobuo Kamiiya, Seiki Kuramitsu, Ryota Kuroki
    • Journal Title

      Acta Cryst.

      Volume: F68 Pages: 49-52

    • DOI

      10.1107/s1744309111044551

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21370049, KAKENHI-PROJECT-22390010, KAKENHI-PROJECT-24227002, KAKENHI-PLANNED-24107003
  • [Journal Article] Substrate recognition mechanism of a glycosyltrehalose trehalohydrolase from Sulfolobus solfataricus KM12012

    • Author(s)
      Okazaki N, Tamada T, Feese MD, Kato M, Miura Y, Komeda T, Kobayashi K, Kondo K, Blaber M, Kuroki R
    • Journal Title

      Protein Scinece

      Volume: 287 Pages: 14023-14039

    • DOI

      10.1002/pro.2039

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Journal Article] Towards investigation of the inhibitorrecognition mechanisms of drug-target proteins by neutron crystallography.2012

    • Author(s)
      Kuroki R, Okazaki N, Adachi M, Ohhara T, Kurihara K, Tamada T
    • Journal Title

      Acta Crystallogr. D Biol. Crystallogr

      Volume: 66 Pages: 1126-1130

    • DOI

      10.1107/s0907444910034967

    • Data Source
      KAKENHI-PROJECT-22390010
  • [Journal Article] X-ray and neutron protein crystallographic analysis of the trypsin-BPTI complexr2010

    • Author(s)
      Kawamura K, Yamada T, Kurihara K, Tamada T, Kuroki R, Tanaka I, Takahashi H, Niimura N
    • Journal Title

      Acta Crystallogr. D Biol. Crystallogr

      Volume: 67 Pages: 140-148

    • DOI

      10.1107/s0907444910053382

    • Data Source
      KAKENHI-PROJECT-22390010
  • [Journal Article] 中性子回折による蛋白質単結晶の構造解析2010

    • Author(s)
      栗原和男、岡崎伸生、黒木良太
    • Journal Title

      Radioisotopes 59巻

      Pages: 263-277

    • NAID

      10026244762

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] Towards investigation of the inhibitor-recognition mechanisms of drug-target proteins by neutron crystallography2010

    • Author(s)
      R.Kuroki, et al
    • Journal Title

      Acta Crystallogr.D Biol.Crystallogr.

      Volume: 66 Pages: 1126-1130

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Journal Article] 中性子を用いた創薬標的蛋白質の立体構造解析2010

    • Author(s)
      安達基泰、黒木良太
    • Journal Title

      タンパク質核酸酵素 55

      Pages: 82-87

    • NAID

      40016985468

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] 中性子構造解析および超高分解能X線構造解析によるエラスターゼの高度な機能解明2010

    • Author(s)
      玉田太郎、黒木良太、木下誉富、多田俊治
    • Journal Title

      日本結晶学会誌 52

      Pages: 133-137

    • NAID

      10026402487

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] タンパク質構造解析における中性子結晶学2010

    • Author(s)
      黒木良太
    • Journal Title

      日本結晶学会誌 52

      Pages: 48-51

    • NAID

      10026107839

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] タンパク質構造解析における中性子結晶学2010

    • Author(s)
      黒木良太
    • Journal Title

      日本結晶学会誌 52巻

      Pages: 48-51

    • NAID

      10026107839

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] 中性子と放射光の相補的な利用による創薬標的タンパク質の立体構造解析2010

    • Author(s)
      黒木良太, 他4名
    • Journal Title

      薬学雑誌

      Volume: 130 Pages: 957-964

    • NAID

      130000259451

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Journal Article] 中性子と放射光の相補的な利用による創薬標的タンパク質の立体構造解析2010

    • Author(s)
      黒木良太、玉田太郎、栗原和男、大原高志、安達基泰
    • Journal Title

      薬学雑誌 130巻

      Pages: 657-664

    • NAID

      130000259451

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] 中性子を用いた創薬標的蛋白質の立体構造解析2010

    • Author(s)
      安達基泰、黒木良太
    • Journal Title

      蛋白質核酸酵素 55巻

      Pages: 82-87

    • NAID

      40016985468

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] 中性子構造解析および超高分解能X線構造解析によるエラスターゼの高度な機能解明2010

    • Author(s)
      玉田太郎、黒木良太、木下誉富、多田俊治
    • Journal Title

      日本結晶学会誌 52巻

      Pages: 133-137

    • NAID

      10026402487

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] 中性子と放射光の相補的な利用による創薬標的タンパク質の立体構造解析2010

    • Author(s)
      黒木 良太、他4名
    • Journal Title

      薬学雑誌

      Volume: 130 Pages: 1126-1130

    • NAID

      130000259451

    • Data Source
      KAKENHI-PROJECT-22390010
  • [Journal Article] Low-barrier hydrogen bond in photoactive yellow protein.2009

    • Author(s)
      Yamaguchi, S., Kamikubo, H., Kurihara, K., Kuroki, R., Niimura, N., Shimizu, N., Yamazaki, Y., Kataoka, M.
    • Journal Title

      Proc Natl Acad Sci USA. 106

      Pages: 440-444

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] A neutron crystallographic analysis of phosphate-free ribonuclease A at 1. 7 A resolution.2009

    • Author(s)
      Yagi, D., Yamada, T., Kurihara, K., Ohnishi, Y., Yamashita, M., Tamada, T., Tanaka, I., Kuroki, R., Niimura, N.
    • Journal Title

      Acta Crystallogr D Biol Crystallogr. 65

      Pages: 892-899

    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] X線と中性子を利用して決定した創薬標的タンパク質の立体構造2009

    • Author(s)
      黒木良太
    • Journal Title

      日本結晶学会誌 51巻

      Pages: 98-99

    • NAID

      10024820466

    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography.2009

    • Author(s)
      Adachi, M., Ohhara, T., Kurihara, K., Tamada, T., Honjo, E., Okazaki, N., Arai, S., Shoyama, Y., Kimura, K., Matsumura, H., Sugiyama, S., Adachi, H., Takano, K., Mori, Y., Hidaka, K., Kimura, T., Hayashi, Y., Kiso, Y., Kuroki, R.
    • Journal Title

      Proc Natl Acad Sci USA. 106

      Pages: 4641-4646

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] 中性子結晶構造解析2009

    • Author(s)
      栗原和男、黒木良太
    • Journal Title

      化学と生物 47巻

      Pages: 868-873

    • NAID

      10026437243

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] 中性子結晶構造解析2009

    • Author(s)
      栗原和男、黒木良太
    • Journal Title

      化学と生物 47

      Pages: 868-873

    • NAID

      10026437243

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] Combined high-resolution neutron and X-ray analysis of inhibited elastase confirms the active-site oxyanion hole but rules against a low-barrier hydrogen bond.2009

    • Author(s)
      Tamada, T., Kinoshita, T., Kurihara, K., Adachi, M., Ohhara, T., Imai, K., Kuroki, R., Tada, T.
    • Journal Title

      J Am Chem Soc. 131

      Pages: 11033-11040

    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] Engineering an improved crystal contact across a solvent-mediated interface of human fibroblast growth factor 1.2009

    • Author(s)
      Meher, A.K., Blaber, S.I., Lee, J., Honjo, E., Kuroki, R., Blaber, M.
    • Journal Title

      Acta Crystallogr Sect F Struct Biol Cryst Commun. 65

      Pages: 1136-1140

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] A neutron crystallographic analysis of T6 porcine insulin at 2. 1 A resolution.2009

    • Author(s)
      Iwai, W., Yamada, T., Kurihara, K., Ohnishi, Y., Kobayashi, Y., Tanaka, I., Takahashi, H., Kuroki, R., Tamada, T., Niimura, N.
    • Journal Title

      Acta Crystallogr D Biol Crystallogr. 65

      Pages: 1042-1050

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S2' pocket.2009

    • Author(s)
      Hidaka, K., Kimura, T., Abdel-Rahman, H.M., Nguyen, J.T., McDaniel, K.F., Kohlbrenner, W.E., Molla, A., Adachi, M., Tamada, T., Kuroki, R., Katsuki, N., Tanaka, Y., Matsumoto, H., Wang, J., Hayashi, Y., Kempf, D.J., Kiso, Y.
    • Journal Title

      J Med Chem. 52(23)

      Pages: 7604-7617

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] Crystallization and preliminary neutron diffraction studies of HIV-1 protease cocrystallized with inhibitor KNI-272.2008

    • Author(s)
      Matsumura, H., Adachi, M., Sugiyama, S., Okada, S., Yamakami, M., Tamada, T., Hidaka, K., Hayashi, Y., Kimura, T., Kiso, Y., Kitatani, T., Maki, S., Yoshikawa, H.Y., Adachi, H., Takano, K., Murakami, S., Inoue, T., Kuroki, R., Mori, Y.
    • Journal Title

      Acta Crystallogr Sect F64

      Pages: 1003-1006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] Residue 134 determines the dimer-tetramer assembly of nucleoside diphosphate kinase from moderately halophilic bacteria.2008

    • Author(s)
      Tokunaga, H., Ishibashi, M., Arisaka, F., Arai, S., Kuroki, R., Arakawa, T., Tokunaga, M.
    • Journal Title

      FEBS Lett. 582

      Pages: 1049-1054

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] A neutron crystallographic analysis of a cubic porcine insulin at pD 6. 6.2008

    • Author(s)
      Ishikawa, T., Chatake, T., Ohnishi Y., Tanaka, I., Kurihara, K., Kuroki, R., Niimura N.
    • Journal Title

      Chemical Physics 343

      Pages: 152-158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] Crystallization and preliminary X-ray diffraction studies of polyketide synthase-1 (PKS-1) from Cannabis sativa.2008

    • Author(s)
      Taguchi, C., Taura, F., Tamada, T., Shoyama, Y., Shoyama, Y., Tanaka, H., Kuroki, R., Morimoto, S.
    • Journal Title

      Acta Crystallogr. F64

      Pages: 217-220

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] Mutagenesis of the crystal contact of acidic fibroblast growth factor.2008

    • Author(s)
      Honjo, E., Tamada, T., Adachi, M., Kuroki, R., Meher, A., Blaber, M.
    • Journal Title

      J. Synchrotron Radiat. 15

      Pages: 285-287

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] Crystallization of porcine pancreatic elastase and a preliminary neutron diffraction experiment.2007

    • Author(s)
      Kinoshita, T., Tamada, T., Imai, K., Kurihara, K., Ohhara, T., Tada, T., Kuroki, R.
    • Journal Title

      Acta Cryst. F63

      Pages: 315-317

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] Protonation states of buried histidine residues in human deoxyhemoglobin revealed by neutron crystallography.2007

    • Author(s)
      Chatake, T., Shibayama, N., Park, S.Y., Kurihara, K.., Tamada, T., Tanaka, I., Niimura, N., Kuroki, R., Morimoto, Y.
    • Journal Title

      J. Am. Chem. Soc. 129

      Pages: 14840-14841

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] “Crystal Lattice Engineering"an approach to engineer protein crystal contacts by creating intermolecular symmetry: Crystallization and structure determination of a mutant human RNase 1 with a hydrophobic interface of leucines.2007

    • Author(s)
      Yamada, H., Tamada, T., Kosaka, M., Miyata, K., Fujiki, S., Tano, M., Moriya, M., Yamanishi, M., Honjo, E., Tada, H., Ino, T., Yamaguchi, H., Futami, J., Seno, M., Nomoto, M., Hirata, T., Yoshimura, M., Kuroki, R.
    • Journal Title

      Protein Science 16

      Pages: 1389-1397

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] A Dinuclear Ni(μ-H)Ru Complex Derived from H2.2007

    • Author(s)
      Ogo, S., Kabe, R., Uehara, K., Kure, B., Nishimura, T., Menon, S.C., Harada, R., Fukuzumi, S., Higuchi, Y., Ohhara, T., Tamada, T., Kuroki, R.
    • Journal Title

      Science 316

      Pages: 585-587

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] Structural refinement and extraction of hydrogen atomic positions in polyoxymethylene crystal based on first successful measurements of 2-dimensinal high-energy synchrotron x-ray diffraction and wide-angle neutron diffraction pattern of hydrogenated and deuterated species.2007

    • Author(s)
      Tashiro, K., Hanesaka, M., Ohhara, T., Ozeki, T., Kitano, T., Nishu, T., Kurihara, K., Tamada, T., Kuroki, R., Fujiwara, S., Tanaka, I., Niimura N.
    • Journal Title

      Polymer J. 39

      Pages: 1253-1273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Journal Article] Homodimeric Cross-over Structure of the Human GCSF-Receptor Signaling Complex.2006

    • Author(s)
      Tamada, T., Honjo, E., Maeda, Y., Okamoto, T., Ishibashi, M., Tokunaga, M., Kuroki, R.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 103

      Pages: 3135-3140

    • Data Source
      KAKENHI-PROJECT-17631009
  • [Journal Article] 中性子産業利用の展開「生体高分子に立体構造を精密に調べる」2006

    • Author(s)
      黒木良太
    • Journal Title

      月刊エネルギー 39

      Pages: 71-73

    • Data Source
      KAKENHI-PROJECT-17631009
  • [Journal Article] 生体高分子の立体構造を精密に調べる2006

    • Author(s)
      黒木良太
    • Journal Title

      月刊エネルギー 39

      Pages: 71-73

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17510186
  • [Journal Article] Crystallization of Δ^1-tetrahydrocannabinolic acid (THCA) synthase from Cannabis sativa2005

    • Author(s)
      Shoyama, Y., Takeuchi, A., Taura, F., Tamada, T., Adachi, M., Kuroki.R., Shoyama, Y., Morimoto.S.
    • Journal Title

      Acta Crystalgr. F61

      Pages: 799-801

    • Data Source
      KAKENHI-PROJECT-17631009
  • [Journal Article] Crystallization of a 2:2 Complex of Granulocyte Colony Stimulating Factor (GCSF) with the Ligand Binding Region of GCSF Receptor2005

    • Author(s)
      Honjo, E., Tamada, T., Maeda, Y., Koshiba, T., Matsukura, Y., Okamoto, T., Ishibashi, M., Tokunaga, M., Kuroki, R.
    • Journal Title

      Acta Crystalgr. F61

      Pages: 788-790

    • Data Source
      KAKENHI-PROJECT-17631009
  • [Journal Article] Creation of the Intermolecular Disulfide Bonded Crystal to Observe Tertiary Structures in Different Solvent Conditions

    • Author(s)
      kuroki et al.
    • Journal Title

      manuscript (in preparation)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17510186
  • [Journal Article] Creation of the Intermolecular Disulfide Bonded Crystal to Observe Tertiary Structures in Different Solvent Conditions

    • Author(s)
      Kuroki et al.
    • Journal Title

      (manuscript in preparation)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17510186
  • [Journal Article] Tertiary Structure Analysis of Biomacromolecules

    • Author(s)
      Ryota Kuroki
    • Journal Title

      Energy 39(in Japanese)

      Pages: 71-73

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17510186
  • [Patent] 生体分子の大型結晶育成のための方法2013

    • Inventor(s)
      新井 栄揮、黒木良太
    • Industrial Property Rights Holder
      独立行政法人日本原子力研究開発機構
    • Acquisition Date
      2013-04-05
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Patent] 生産性および不凍活性を向上させた改変型不凍タンパク質とその製造方法2010

    • Inventor(s)
      黒木良太, 他5名
    • Industrial Property Rights Holder
      独立行政法人日本原子力研究開発機構, 他名
    • Industrial Property Number
      2010-105583
    • Filing Date
      2010-04-30
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Patent] 生体分子の大型結晶育成のための方法および装置2009

    • Inventor(s)
      新井栄揮、黒木良太
    • Industrial Property Rights Holder
      日本原子力研究開発機構
    • Filing Date
      2009-07-02
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] X-Ray Structure Analysis of the Single-Chain Derivative of HIV-1 Protease2012

    • Author(s)
      Motoyasu Adachi and Ryota Kuroki
    • Organizer
      The 12th Japan China Korea Joint Symposium on Enzyme Engineering
    • Place of Presentation
      金沢全日空ホテル(石川県金沢市)
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Presentation] 血球系細胞に関わる増殖因子の構造と機能2012

    • Author(s)
      黒木良太
    • Organizer
      基生研研究会「モデル生物・非モデル生物のプロテオミクスが拓く生物学」
    • Place of Presentation
      基礎生物学研究所(愛知県岡崎市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Presentation] 生体物質の構造解析2012

    • Author(s)
      黒木良太
    • Organizer
      中性子利用技術移転推進プログラム・シンポジウム
    • Place of Presentation
      日本科学未来館(東京都)(依頼講演)
    • Year and Date
      2012-02-09
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Presentation] 生体物質の構造解析2012

    • Author(s)
      黒木 良太
    • Organizer
      中性子利用技術移転推進プログラム・シンポジウム
    • Place of Presentation
      日本科学未来館(東京都)
    • Year and Date
      2012-02-09
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Presentation]2012

    • Author(s)
      Motoyasu Adachi and Ryota Kuroki
    • Organizer
      The 12th Japan China Korea Joint Symposium on Enzyme Engineering
    • Place of Presentation
      金沢全日空ホテル(金沢市)
    • Year and Date
      2012-05-29
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Presentation] 中性子利用による新しい蛋白質科学研究2012

    • Author(s)
      黒木 良太
    • Organizer
      第12回蛋白質科学会ワークショップ、中性子を用いたタンパク質科学研究の新展開
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2012-06-21
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Presentation] 創薬標的タンパク質の立体構造解析2011

    • Author(s)
      黒木良太
    • Organizer
      日本化学会関東支部講演会「創薬を指向したタンパク質科学」
    • Place of Presentation
      日本化学会7階ホール(東京都)(招待講演)
    • Year and Date
      2011-10-16
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Presentation] Peptidic inhibitor recognition of the drug target proteins investigated by neutron diffraction2011

    • Author(s)
      黒木良太
    • Organizer
      第14回ペプチドフォーラム
    • Place of Presentation
      鹿児島大学理学部1号館2階大会議室(鹿児島市)(招待講演)
    • Year and Date
      2011-12-17
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Presentation] Peptidic inhibitor recognition of the drug target proteins investigated by neutron diffraction2011

    • Author(s)
      黒木 良太
    • Organizer
      第14回ペプチドフォーラム
    • Place of Presentation
      鹿児島大学理学部1号館2階大会議室(鹿児島市)
    • Year and Date
      2011-02-17
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Presentation] 創薬標的タンパク質の立体構造解析2011

    • Author(s)
      黒木 良太
    • Organizer
      日本化学会関東支部講演会「創薬を指向したタンパク質科学」
    • Place of Presentation
      日本化学会7階ホール(東京都)
    • Year and Date
      2011-10-16
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Presentation] 放射能汚染と蛋白質科学-汚染を除去する蛋白質の創製は可能か?2011

    • Author(s)
      新井 栄揮、黒木 良太
    • Organizer
      第11回 日本蛋白質科学会年会
    • Place of Presentation
      ホテル阪急エキスポパーク(吹田市)
    • Year and Date
      2011-06-09
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Presentation] 放射能汚染と蛋白質科学-汚染を除去する蛋白質の創製は可能か?2011

    • Author(s)
      新井栄揮、黒木良太
    • Organizer
      第11回日本蛋白質科学会年会
    • Place of Presentation
      ホテル阪急エキスポパーク(吹田市)(依頼講演)
    • Year and Date
      2011-06-09
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Presentation] 生体高分子専用高分解能中性子結晶回折計~装置のコンセプト~装置を使った研究の展開2010

    • Author(s)
      黒木 良太
    • Place of Presentation
      東北大学多元物質科学研究所(仙台市)
    • Year and Date
      2010-12-11
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Presentation] 生体高分子専用高分解能中性子結晶回折計I)装置のコンセプト~装置を使った研究の展開2010

    • Author(s)
      黒木良太
    • Organizer
      日本中性子科学会・サテライトシンポジウム
    • Place of Presentation
      東北大学多元物質科学研究所
    • Year and Date
      2010-12-11
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Presentation] Collaborative Use of X-ray and Neutron Diffraction for Investigation of Enzyme-Inhibitor Interaction2009

    • Author(s)
      Ryota Kuroki
    • Organizer
      Taiwan-Japan Joint Seminar on Crystallography and IPR Seminar
    • Place of Presentation
      大阪大学・蛋白質研究所
    • Year and Date
      2009-12-07
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] Neutron Crystallography for Investigation of Catalytic Mechanism of HIV-1 protease2009

    • Author(s)
      安達基泰 黒木良太, 他
    • Organizer
      ATI国際フォーラム
    • Place of Presentation
      テクノ交流間リコッティ(茨城県東海村)
    • Year and Date
      2009-03-10
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] 放射線抵抗性細菌由来DNA修復促進蛋白質PprAの構造機構解析2009

    • Author(s)
      山田貢、安達基泰、佐藤勝也、玉田太郎、由良敬、黒木良太、鳴海一成
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-19380054
  • [Presentation] X線と中性子を用いた創薬標的タンパク質の立体構造解析2009

    • Author(s)
      黒木良太
    • Organizer
      「生体超分子構造」第6回公開シンポジウム
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府豊中市)
    • Year and Date
      2009-12-01
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] Collaborative Use of X-ray and Neutron Diffraction for Investigation of Enzyme-Inhibitor Interaction2009

    • Author(s)
      Ryota Kuroki
    • Organizer
      Taiwan-Japan Joint Seminar on Crystallography and IPR Seminar
    • Place of Presentation
      大阪大学・蛋白質研究所(大阪府吹田市)
    • Year and Date
      2009-12-07
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] 中性子と放射光の相補的な利用による創薬標的タンパク質の立体構造解析2009

    • Author(s)
      黒木良太
    • Organizer
      日本薬学会第129年会一般シンポジウムS-30、「創薬を目指す量子ビーム施設-放射光と中性子の有効利用-」
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-03-27
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] 中性子で見るタンパク質全水素原子の振る舞い~X線結晶構造解析との比較でわかること~2009

    • Author(s)
      黒木良太
    • Organizer
      日本結晶学会
    • Place of Presentation
      関西学院大学
    • Year and Date
      2009-12-05
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] Structure of Enzyme-Inhibitor Complex by Neutron Crystallography2009

    • Author(s)
      Ryota Kuroki
    • Organizer
      Neutrons in Biology
    • Place of Presentation
      Santa Fe, AR (USA)
    • Year and Date
      2009-10-25
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] 中性子と放射光の相補的な利用による創薬標的タンパク質の立体構造解析2009

    • Author(s)
      黒木良太
    • Organizer
      日本薬学会第129回年回
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-03-27
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] 医薬品作用の基本原理:分子のかたちと分子認識2008

    • Author(s)
      黒木良太
    • Organizer
      九州大学薬学部公開講座
    • Place of Presentation
      九州大学(福岡市)
    • Year and Date
      2008-07-20
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] X線と中性子を用いて解析したヒト免疫不全ウイルスプロテアーゼ-阻害剤複合体の立体構造2008

    • Author(s)
      黒木良太
    • Organizer
      酵素工学研究会30周年記念シンポジウム
    • Place of Presentation
      かずさアカデミアホール(千葉県木更津市)
    • Year and Date
      2008-11-13
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] Structures of Drug-Target Proteins Determined by both X-ray and Neutron Diffraction2008

    • Author(s)
      黒木良太
    • Organizer
      IUCr-International Union of Crystall ography. IUCr Congress 08
    • Place of Presentation
      Grand Cube Osaka (大阪市)
    • Year and Date
      2008-08-25
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] Structures of Drug-Target Proteins Determined by both X-ray and Neutron Diffraction2008

    • Author(s)
      Ryota Kuroki
    • Organizer
      The 21st Congress of the International Union of Crystallography (IUCr2008)
    • Place of Presentation
      Osaka International Convention Center. (Osaka)
    • Year and Date
      2008-08-25
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] 医薬品作用の基本原理:タンパク質のかたちと分子認識2008

    • Author(s)
      黒木良太
    • Organizer
      九州大学薬学部公開講座
    • Place of Presentation
      福岡市
    • Year and Date
      2008-07-20
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] X線と中性子を用いて観測した蛋白質や水和水の構造2008

    • Author(s)
      黒木良太
    • Organizer
      中性子と放射光の相補利用セミナー
    • Place of Presentation
      臨床研究情報センター(神戸市)
    • Year and Date
      2008-02-08
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] 定常炉中性子によるタンパク質立体構造解析2007

    • Author(s)
      黒木 良太
    • Organizer
      日本中性子科学会第7回年会
    • Place of Presentation
      九州大学(福岡)
    • Year and Date
      2007-11-28
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] 甲性子を用いたタンパク質の立体構造解析の現状と新展開2007

    • Author(s)
      黒木 良太
    • Organizer
      第7回日本蛋白質科学会ワークショップ
    • Place of Presentation
      仙台国際会議場(仙台)
    • Year and Date
      2007-05-25
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] 「X線と中性子を用いて観測した蛋白質水和水の熱力学的特徴2007

    • Author(s)
      黒木良太
    • Organizer
      日本生物物理学会シンポジウム、立体構造から生体分子間相互作用の熱力学へ
    • Place of Presentation
      横浜国際会議場(横浜市)
    • Year and Date
      2007-12-05
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] 放射線抵抗性細菌デイノコッカス由来の新規なDNA修復促進蛋白質PprAのDNAとの相互作用解析2007

    • Author(s)
      安達基泰、玉田太郎、佐藤勝也、由良敬、鳴海一成、黒木良太
    • Organizer
      第30回日本分子生物学会年会第80回日本生化学会大会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
    • Data Source
      KAKENHI-PROJECT-19380054
  • [Presentation] X線と中性子を用いて観測した蛋白質水和水の熱力学的特徴2007

    • Author(s)
      黒木 良太
    • Organizer
      第45回日本生物物理学会年会ワークショップ
    • Place of Presentation
      横浜国際会議場(横浜)
    • Year and Date
      2007-12-21
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] Protein structure analysis using neutron diffraction2007

    • Author(s)
      黒木 良太
    • Organizer
      Lecture at Max Plank Inst.
    • Place of Presentation
      Max Plank Inst.
    • Year and Date
      2007-09-10
    • Data Source
      KAKENHI-PROJECT-19370046
  • [Presentation] Structure of Enzyme-Inhibitor Complex by Neutron Crystallography

    • Author(s)
      Ryota Kuroki
    • Organizer
      Bragg Institute Seminar
    • Place of Presentation
      Bragg Institute (シドニー・オーストラリア)
    • Invited
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Presentation] 中性子利用による新しい蛋白質科学研究

    • Author(s)
      黒木良太
    • Organizer
      中性子を用いたタンパク質科学研究の新展開
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-22390010
  • [Presentation] 建設へのこれまでの経緯

    • Author(s)
      黒木良太
    • Organizer
      構造生物学研究における中性子と放射光の連携~J-PARC/MLF生体高分子専用高分解能中性子回折計の建設実現に向けて
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Data Source
      KAKENHI-PROJECT-22390010
  • 1.  TAMADA Taro (50391248)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 30 results
  • 2.  KIDOKORO Shun-ichi (80195320)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  ADACHI Motoyasu (60293958)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 16 results
  • 4.  KURIHARA Kazuo (50354890)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 20 results
  • 5.  ODAKA Masafumi (20224248)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  SAITO Minoru (60196011)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  OHHARA Takashi (60391249)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 8.  YOHDA Masafumi (50250105)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  UMINO Hisao (20399421)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  OKAZAKI Nobuo (60391900)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 11.  NARUMI Issay (90343920)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 12.  YURA Kei (50252226)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 13.  ITO Yuji (60223195)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  ARIMA Naomichi (30175997)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  森元 聡 (60191045)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 16.  米本 照代 (30265714)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  野口 恵一 (00251588)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  松村 洋寿 (60741824)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  神谷 信夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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