Koike-Kumagai Makiko 小池・熊谷牧子

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KOIKE Makiko 小池牧子

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Researcher Number	30391949
Other IDs	https://orcid.org/0000-0002-3977-4332
Affiliation (Current)	2026: 大阪大学, 大学院医学系研究科, 特任助教(常勤)
Affiliation (based on the past Project Information) *help	2026: 大阪大学, 大学院医学系研究科, 特任助教(常勤) 2022 – 2024: 大阪大学, 大学院医学系研究科, 寄附講座助教 2021: 大阪大学, 医学系研究科, 寄附講座助教 2004: RIKEN, Cellular Dynamics Laboratory, Contract Technical Scientist, 今本細胞核機能研究室, 協力研究員
Review Section/Research Field	Principal Investigator Basic Section 53050:Dermatology-related Except Principal Investigator Medium-sized Section 53:Organ-based internal medicine and related fields / Cell biology
Keywords	Principal Investigator ｍTORC1 / てんかん / 神経皮膚症候群 / ラパマイシン / エストロゲン / 結節性硬化症 / ｍTOR / シロリムス / ERα / ミクログリア … More / 行動解析 / TSCモデルマウス / 結節性硬化症関連精神神経障害（TAND) / 結節性硬化症（TSC) … More Except Principal Investigator importin β / シロリムス / シロリムス局所外用療法 / mTORC1阻害剤 / 中枢神経病変治療用外用薬 / 新規薬剤輸送機構 / 神経の逆行性軸索輸送 / 血液脳関門 / てんかん / 結節性硬化症 / シロリムス局所外用剤 / 70kDa heat-shock cognate protein / semi-intact cells / nuclear pore comlex / single molecule imaging / nuclear transport / 輸送担体 / 核膜孔複合体構成因子 / 核局在化シグナル / β-カテニン / 低分子量GTPase Ran / Importinβ / 分子シャペロンhsc70 / 1分子イメージング / セミインタクト細胞 / importinβ / 核膜孔複合体 / 核-細胞質間輸送 Less

結節性硬化症関連神経精神疾患の重症度の差に関連する遺伝子の同定Principal Investigator
- Principal Investigator
  
  小池・熊谷牧子
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  The University of Osaka
Elucidation of a Novel Skin-to-Brain Drug Transport Mechanism Independent of the Blood-Brain Barrier
- Principal Investigator
  
  Wataya-Kaneda Mari
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Osaka University
Elucidation of the cause of phenotypic differences in tuberous sclerosis complex using model micePrincipal Investigator
- Principal Investigator
  
  Koike-Kumagai Makiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Osaka University
Analysis of nuclear pore translocation mechanism : single molecule analysis and biochemical approach
- Principal Investigator
  
  IMAMOTO Naoko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  RIKEN

All 2023 2022 2021 2005 2004 2003

All Journal Article Presentation

[Journal Article] Sirolimus relieves seizures and neuropsychiatric symptoms via changes of microglial polarity in tuberous sclerosis complex model mice2022
- Author(s)
  Makiko Koike-Kumagai, Manabu Fujimoto, Mari Wataya-Kaneda
- Journal Title
  
  Neuropharmacology
  
  Volume: 218 Pages: 1-16
- DOI
  10.1016/j.neuropharm.2022.109203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08322, KAKENHI-PROJECT-22K18392
[Journal Article] Neuroinflammation and Microglial Polarity: Sirolimus Shifts Microglial Polarity to M2 phenotype in a Mouse Model of Tuberous Sclerosis Complex2022
- Author(s)
  Makiko Koike-Kumagai, Mari Wataya-Kaneda
- Journal Title
  
  J. Exp. Neurol.
  
  Volume: 3 Issue: 2 Pages: 63-70
- DOI
  10.33696/neurol.3.064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08322
[Journal Article] Sirolimus relieves seizures and neuropsychiatric symptoms via changes of microglial polarity in tuberous sclerosis complex model mice2022
- Author(s)
  Makiko Koike-Kumagai, Mari Wataya-Kaneda*
- Journal Title
  
  J Exp Neurol.
  
  Volume: 3 Pages: 63-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K18392
[Journal Article] Clinical practice guidelines for pseudoxanthoma elasticum (2017)2022
- Author(s)
  Iwanaga Akira、Utani Atsushi、Koike Yuta、Okubo Yumi、Kuwatsuka Yutaka、Endo Yuichiro、Tanizaki Hideaki、Wataya‐Kaneda Mari、Hatamochi Atsushi、Minaga Kosuke、Ogi Tomoo、Yamamoto Yosuke、Ikeda Satoshi、Tsuiki Eiko、Tamura Hiroshi、Maemura Koji、Kitaoka Takashi、Murota Hiroyuki
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 49 Issue: 3 Pages: 91-98
- DOI
  10.1111/1346-8138.16301
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08654, KAKENHI-PROJECT-21K09740, KAKENHI-PROJECT-22K18392, KAKENHI-PROJECT-21K16231
[Journal Article] The 70-kD heat shock cognate protein(hsc70) facilitates the nuclear export of the import receptors2005
- Author(s)
  Shingo Kose, Maiko Furuta, Makiko Koike, Yoshihiro Yoneda, Naoko Imamoto
- Journal Title
  
  J.Cell Biol. 171
  
  Pages: 19-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370090
[Journal Article] β-Catenin shows an overlapping sequence requirement but distinct molecular interaction for its hi-directional passage through nuclear pores.2004
- Author(s)
  Makiko Koike
- Journal Title
  
  J. Biol. Chem. 279
  
  Pages: 34038-34047
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15370090
[Journal Article] Architecture and Dynamics of Nuclear Pore Complex2004
- Author(s)
  Naoko Imamoto, Maiko Furuta, Makiko Koike, Shingo Kose
- Journal Title
  
  Dynamics of Cell Nucleus
  
  Pages: 195-201
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370090
[Journal Article] β-catenin shows an overlapping sequence requirement but distinct molecular interactions for its bi-directional passage through nuclear pores2004
- Author(s)
  Makiko Koike
- Journal Title
  
  J.Biol.Chem 279
  
  Pages: 34038-34047
- Data Source
  KAKENHI-PROJECT-15370090
[Journal Article] β-Catenin shows an overlapping sequence requirement but distinct molecular interaction for its bi-directional passage through nuclear pores2004
- Author(s)
  Makiko Koike, Shingo Kose, Maiko Furuta, Naoko Taniguchi, Fumihiko Yokota, Yoshihiro Yoneda, Naoko Imamoto
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 34038-34047
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370090
[Journal Article] Heat-shock induced nuclear retention and recycling inhibition of importin α2004
- Author(s)
  Maiko Furuta, Shingo Kose, Makiko Koike, Takeshi Shimi, Yasushi Hiraoka, Yoshihiro Yoneda, Tokuko Haraguchi, Naoko Imamoto
- Journal Title
  
  Genes Cells 9
  
  Pages: 429-441
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370090
[Journal Article] Nucleocytoplasmic transport : mechanism and pathways2003
- Author(s)
  Naoko Imamoto, Makiko Koike, Maiko Furuta
- Journal Title
  
  Experimental Medicine Vol.21
  
  Pages: 1842-1849
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370090
[Presentation] Epilepsy and TAND in the tuberous sclerosis complex are caused by an alteration in microglial polarity to M1 and sirolimus cures them by returning microglial polarity to M2.2023
- Author(s)
  Emi Kaneda, Makiko Koike-Kumagai and Mari Wataya-Kaneda
- Organizer
  2023 International TSC Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08322
[Presentation] Sirolimus alters microglial polarity leading to improvement of neuropsychiatric symptoms of tuberous sclerosis complex mice model.2023
- Author(s)
  Makiko Koike-Kumagai, Mari Wataya-Kaneda
- Organizer
  1 st. International Conference of Neuroscience and Neurology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08322
[Presentation] Sirolimus alters microglial polarity leading to improvement of neuropsychiatric symptoms of tuberous sclerosis complex mice model.2023
- Author(s)
  Makiko Koike-Kumagai, Mari Wataya-Kaneda
- Organizer
  1 st. International Conference of Neuroscience and Neurology. Hybrid event in Dubai, UAE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18392
[Presentation] Epilepsy and TAND in the tuberous sclerosis complex are caused by an alteration in microglial polarity to M1 and sirolimus cures them by returning microglial polarity to M2.2023
- Author(s)
  Emi Kaeda, Makiko Koike-Kumagai, Mari Wataya-Kaneda
- Organizer
  2023 International TSC Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18392
[Presentation] The microglial decreased phagocytosis in olfactory bulb is responsible for neuropsychiatric disorders in tuberous sclerosis complex model mice.2021
- Author(s)
  Makiko Koike-Kumagai
- Organizer
  50 th Annual ESDR meeting, Virtual, Sep. 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08322

1. IMAMOTO Naoko (20202145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. KOSE Shingo (90333278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. Wataya-Kaneda Mari (70397644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 谷口直子 (90360586)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 望月秀樹 (90230044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 前田真一郎 (60452398)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中村歩 (40602686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 小池雄太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koike-Kumagai Makiko 小池・熊谷 牧子

KOIKE Makiko 小池 牧子

Research Projects

Research Products

Co-Researchers

結節性硬化症関連神経精神疾患の重症度の差に関連する遺伝子の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of a Novel Skin-to-Brain Drug Transport Mechanism Independent of the Blood-Brain Barrier

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the cause of phenotypic differences in tuberous sclerosis complex using model micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of nuclear pore translocation mechanism : single molecule analysis and biochemical approach

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Sirolimus relieves seizures and neuropsychiatric symptoms via changes of microglial polarity in tuberous sclerosis complex model mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neuroinflammation and Microglial Polarity: Sirolimus Shifts Microglial Polarity to M2 phenotype in a Mouse Model of Tuberous Sclerosis Complex2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sirolimus relieves seizures and neuropsychiatric symptoms via changes of microglial polarity in tuberous sclerosis complex model mice2022

Author(s)

Journal Title

Data Source

[Journal Article] Clinical practice guidelines for pseudoxanthoma elasticum (2017)2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The 70-kD heat shock cognate protein(hsc70) facilitates the nuclear export of the import receptors2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] β-Catenin shows an overlapping sequence requirement but distinct molecular interaction for its hi-directional passage through nuclear pores.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Architecture and Dynamics of Nuclear Pore Complex2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] β-catenin shows an overlapping sequence requirement but distinct molecular interactions for its bi-directional passage through nuclear pores2004

Author(s)

Journal Title

Data Source

[Journal Article] β-Catenin shows an overlapping sequence requirement but distinct molecular interaction for its bi-directional passage through nuclear pores2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Heat-shock induced nuclear retention and recycling inhibition of importin α2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Nucleocytoplasmic transport : mechanism and pathways2003

Author(s)

Journal Title

Koike-Kumagai Makiko 小池・熊谷牧子

KOIKE Makiko 小池牧子