Shibata Norihito 柴田識人

… Alternative Names

柴田識人シバタノリヒト

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Researcher Number	30391973
Other IDs
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, 生化学部, 部長
Affiliation (based on the past Project Information) *help	2025: 国立医薬品食品衛生研究所, 生化学部, 部長 2023: 国立医薬品食品衛生研究所, 生化学部, 部長 2019 – 2023: 国立医薬品食品衛生研究所, 生化学部, 室長 2018: 国立医薬品食品衛生研究所, 遺伝子医薬部, 主任研究官 2014 – 2016: 国立医薬品食品衛生研究所, 遺伝子医薬部, 主任研究官 2007: 理研, 研究員 2006: 独立行政法人理化学研究所, 辻本細胞生化学研究室, 基礎科学特別研究員
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 43030:Functional biochemistry-related / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Basic Section 43060:System genome science-related
Keywords	Principal Investigator ゲノム編集技術 / タンパク質制御 / Cas9 / ゲノム編集 / 融合キナーゼタンパク質 / がん / タンパク質分解 / がん特異的融合タンパク質 / 脱ユビキチン化酵素 / 酸化コレステロール … More / フィブラート系薬剤 / PPARα / 絶食 / スクアレンエポキシダーゼ / コレステロール生合成 … More Except Principal Investigator CRISPR / DNA２本鎖切断 / 細胞周期 / レポーター細胞 / DNA修復 / ゲノム編集 Less

CRISPR/Cas9による構造変異に起因した毒性の分子機構解析Principal Investigator
- Principal Investigator
  
  柴田識人
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  National Institute of Health Sciences
Development of cell-cycle-regulated CRISPR/Cas system
- Principal Investigator
  
  近藤一成
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  Showa Women's University
  National Institute of Health Sciences
Cas9タンパク質の制御によるCRISPR/Cas9オフターゲット編集の抑制Principal Investigator
- Principal Investigator
  
  柴田識人
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  National Institute of Health Sciences
Development of novel anti-tumor drugs targeting the stability of oncogenic fusion kinase proteinsPrincipal Investigator
- Principal Investigator
  
  Shibata Norihito
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Institute of Health Sciences
Analysis of antiviral activity of 25-hydroxycholesterolPrincipal Investigator
- Principal Investigator
  
  Shibata Norihito
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Health Sciences
新規コレステロール代謝調節機構の創薬応用の検討と本機構の持つ新たな生理意義の解明Principal Investigator
- Principal Investigator
  
  柴田識人
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Institute of Physical and Chemical Research

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2006 Other

All Journal Article Presentation Patent

[Journal Article] Investigation of Genetically Modified Maize Imported into Japan in 2021/2022 and the Applicability of Japanese Official Methods2023
- Author(s)
  Soga K, Taguchi C, Sugino M, Egi T, Narushima J, Yoshiba S, Takabatake R, Kondo K, Shibata N
- Journal Title
  
  Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)
  
  Volume: 64 Issue: 6 Pages: 218-225
- DOI
  10.3358/shokueishi.64.218
- ISSN
  0015-6426, 1882-1006
- Year and Date
  2023-12-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06075, KAKENHI-PROJECT-20K05901
[Journal Article] Development of a degrader against oncogenic fusion protein FGFR3-TACC32022
- Author(s)
  Shibata Norihito、Cho Nobuo、Koyama Hiroo、Naito Mikihiko
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 60 Pages: 128584-128584
- DOI
  10.1016/j.bmcl.2022.128584
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07311, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K06075, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502
[Journal Article] Structure?activity relationship study of PROTACs against hematopoietic prostaglandin D<sub>2</sub> synthase2022
- Author(s)
  Murakami Yuki、Osawa Hinata、Kurohara Takashi、Yanase Yuta、Ito Takahito、Yokoo Hidetomo、Shibata Norihito、Naito Mikihiko、Aritake Kosuke、Demizu Yosuke
- Journal Title
  
  RSC Medicinal Chemistry
  
  Volume: 13 Issue: 12 Pages: 1495-1503
- DOI
  10.1039/d2md00284a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K06075, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
[Journal Article] Unbiased prediction of off‐target sites in genome‐edited rice using <scp>SITE‐Seq</scp> analysis on a web‐based platform2022
- Author(s)
  Narushima Jumpei、Kimata Shinya、Shiwa Yuh、Gondo Takahiro、Akimoto Satoshi、Soga Keisuke、Yoshiba Satoko、Nakamura Kosuke、Shibata Norihito、Kondo Kazunari
- Journal Title
  
  Genes to Cells
  
  Volume: 27 Issue: 12 Pages: 706-718
- DOI
  10.1111/gtc.12985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05901, KAKENHI-PROJECT-21K06075
[Journal Article] Development and Validation of a New Robust Detection Method for Low-Content DNA Using ΔΔCq-Based Real-Time PCR with Optimized Standard Plasmids as a Control Sample2022
- Author(s)
  Soga Keisuke、Nakamura Kosuke、Egi Tomohiro、Narushima Jumpei、Yoshiba Satoko、Kishine Masahiro、Mano Junichi、Kitta Kazumi、Takabatake Reona、Shibata Norihito、Kondo Kazunari
- Journal Title
  
  Analytical Chemistry
  
  Volume: 94 Issue: 41 Pages: 14475-14483
- DOI
  10.1021/acs.analchem.2c03680
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05901, KAKENHI-PROJECT-21K06075
[Journal Article] Evaluation of Conversion Factor for Rapid Quantification of Authorized Genetically Modified Maize and Soybean in Japan2022
- Author(s)
  Norihito Shibata、Keisuke Soga, Miyu Sugino, Jumpei Narushima, Satoko Yoshiba, Tomohiro Egi, Reona Takabatake, Kazunari Kondo
- Journal Title
  
  BPB Reports
  
  Volume: 5 Pages: 115-120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06075
[Journal Article] Development of Rapid and Facile Solid‐Phase Synthesis of PROTACs via a Variety of Binding Styles2022
- Author(s)
  Xu Hanqiao、Kurohara Takashi、Takano Reina、Yokoo Hidetomo、Shibata Norihito、Ohoka Nobumichi、Inoue Takao、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  ChemistryOpen
  
  Volume: 11 Issue: 7
- DOI
  10.1002/open.202200131
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K06075, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
[Journal Article] Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer2021
- Author(s)
  Yokoo Hidetomo、Shibata Norihito、Naganuma Miyako、Murakami Yuki、Fujii Kiyonaga、Ito Takahito、Aritake Kosuke、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 12 Issue: 2 Pages: 236-241
- DOI
  10.1021/acsmedchemlett.0c00605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07311, KAKENHI-PROJECT-20K22711, KAKENHI-PROJECT-17K08385, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K05320
[Journal Article] Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design2021
- Author(s)
  Yokoo Hidetomo、Shibata Norihito、Endo Akinori、Ito Takahito、Yanase Yuta、Murakami Yuki、Fujii Kiyonaga、Hamamura Kengo、Saeki Yasushi、Naito Mikihiko、Aritake Kosuke、Demizu Yosuke
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 64 Issue: 21 Pages: 15868-15882
- DOI
  10.1021/acs.jmedchem.1c01206
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K07311, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-20K06568, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K11613, KAKENHI-PROJECT-20K22711
[Journal Article] Strategy for detecting off-target sites in genome-edited rice2021
- Author(s)
  Jumpei Narushima, Shinya Kimata, Yuh Shiwa, Takahiro Gondo, Satoru Akimoto, Keisuke Soga, Satoko Yoshiba, Kosuke Nakamura, Norihito Shibata, Kazunari Kondo
- Journal Title
  
  bioRxiv
  
  Volume: 5/29 Pages: 1-26
- DOI
  10.1101/2021.05.28.446070
- Open Access
- Data Source
  KAKENHI-PROJECT-21H02469, KAKENHI-PROJECT-20K05901
[Journal Article] Protocols for Synthesis of and the Methods to Evaluate the Anticancer Effects2021
- Author(s)
  Tsukumo Yoshinori、Tsuji Genichiro、Yokoo Hidetomo、Shibata Norihito、Ohoka Nobumichi、Demizu Yosuke、Naito Mikihiko
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: 2365 Pages: 331-347
- DOI
  10.1007/978-1-0716-1665-9_18
- ISBN
  9781071616642, 9781071616659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K07311, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-19K07724, KAKENHI-PROJECT-21K05320
[Journal Article] Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells2020
- Author(s)
  Shibata Norihito、Ohoka Nobumichi、Tsuji Genichiro、Demizu Yosuke、Miyawaza Keiji、Ui-Tei Kumiko、Akiyama Tetsu、Naito Mikihiko
- Journal Title
  
  Oncogene
  
  Volume: - Issue: 19 Pages: 3867-3878
- DOI
  10.1038/s41388-020-1253-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07311, KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-17H01537, KAKENHI-PROJECT-17K08385, KAKENHI-PLANNED-18H05502, KAKENHI-ORGANIZER-18H05497
[Journal Article] 脱ユビキチン化酵素阻害によるプロテインノックダウン2020
- Author(s)
  柴田識人, 内藤幹彦
- Journal Title
  
  実験医学
  
  Volume: 38 Pages: 2337-2341
- Data Source
  KAKENHI-PROJECT-18K07311
[Journal Article] がんに対する核酸医薬品の開発2020
- Author(s)
  井上貴雄, 柴田識人
- Journal Title
  
  がん分子標的治療
  
  Volume: 18 Pages: 78-86
- Data Source
  KAKENHI-PROJECT-18K07311
[Journal Article] Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein2019
- Author(s)
  Shibata Norihito、Ohoka Nobumichi、Hattori Takayuki、Naito Mikihiko
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 67 Issue: 3 Pages: 165-172
- DOI
  10.1248/cpb.c18-00703
- NAID
  130007606378
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2019-03-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-18K07311, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] 標的蛋白質分解を誘導するハイブリッド化合物SNIPERsとPROTACs．2018
- Author(s)
  柴田識人, 内藤幹彦
- Journal Title
  
  医学のあゆみ
  
  Volume: 267 Pages: 1069-1075
- Data Source
  KAKENHI-PROJECT-18K07311
[Journal Article] Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy.2016
- Author(s)
  Ohoka N, Shibata N, Hattori T, Naito M.
- Journal Title
  
  Current Cancer Drug Targets
  
  Volume: 16 Issue: 2 Pages: 136-146
- DOI
  10.2174/1568009616666151112122502
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-26860050
[Journal Article] Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.2016
- Author(s)
  Demizu, Y., Shibata, N., Hattori, T., Ohoka, N., Motoi, H., Misawa, T., Shoda, T., Naito, M. & Kurihara, M.
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 26 Issue: 20 Pages: 4865-4869
- DOI
  10.1016/j.bmcl.2016.09.041
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916
[Journal Article] Induction of proteasomal degradation of ERα and subsequent cell death in breast cancer cells2016
- Author(s)
  K. Okuhira, Y. Demizu, T. Hattori, N. Ohoka, N. Shibata, T. Nishimaki-Mogami, H. Okuda, M. Kurihara, M. Naito*
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: 1366 Pages: 549-560
- DOI
  10.1007/978-1-4939-3127-9_42
- ISBN
  9781493931262, 9781493931279
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-16H05090
[Journal Article] Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders.2015
- Author(s)
  Shibata N, Ohoka N, Sugaki Y, Onodera C, Inoue M, Sakuraba Y, Takakura D, Hashii N, Kawasaki N, Gondo Y, Naito M
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290 Issue: 47 Pages: 28428-28437
- DOI
  10.1074/jbc.m115.670901
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-25241016, KAKENHI-PROJECT-25460084
[Journal Article] Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis2006
- Author(s)
  Norihito Shibata
- Journal Title
  
  The FASEB Journal 20
  
  Pages: 2642-2642
- Data Source
  KAKENHI-PROJECT-18790076
[Patent] 新規化合物及び医薬組成物2020
- Inventor(s)
  出水庸介, 柴田識人, 内藤幹彦, 有竹浩介, 横尾英知
- Industrial Property Rights Holder
  出水庸介, 柴田識人, 内藤幹彦, 有竹浩介, 横尾英知
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-122534
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18K07311
[Presentation] Cas9 targeted long-read sequencingによる食品中の外来性遺伝子配列の同定2023
- Author(s)
  成島純平、吉場聡子、細川葵、曽我慶介、杉野御佑、田口千恵、安達玲子、近藤一成、柴田識人
- Organizer
  第４6回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06075
[Presentation] ゲノム編集イネにおけるin vitroオフターゲット予測法SITE-Seqを用いたオフターゲット予測性能の評価2023
- Author(s)
  成島純平、杉野御祐、曽我慶介、吉場聡子、近藤一成、柴田識人
- Organizer
  日本ゲノム編集学会第8回大会
- Data Source
  KAKENHI-PROJECT-21K06075
[Presentation] 造血器型プロスタグランジンD合成酵素選択的タンパク質分解誘導剤の開発2022
- Author(s)
  柴田識人, 横尾英知, 遠藤彬則, 伊藤貴仁, 栁瀨雄太, 村上優貴, 藤井清永, 近藤一成, 佐伯泰, 内藤幹彦, 有竹浩介, 出水庸介
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-18K07311
[Presentation] NGSを用いた網羅的なオフターゲット変異候補部位予測法の高GABA産生ゲノム編集トマトへの適用と検証2022
- Author(s)
  成島純平、杉野御祐、曽我慶介、吉場聡子、柴田識人、近藤一成
- Organizer
  第59回全国衛生化学技術協議会年会
- Data Source
  KAKENHI-PROJECT-21K06075
[Presentation] 遺伝子組換え食品の同定に資する新たなゲノム解析技術の検討2022
- Author(s)
  吉場聡子、成島純平、曽我慶介、杉野御祐、柴田識人、近藤一成
- Organizer
  第59回全国衛生化学技術協議会年会
- Data Source
  KAKENHI-PROJECT-21K06075
[Presentation] Development of a degrader against oncogenic fusion protein FGFR3-TACC32022
- Author(s)
  Norihito Shibata、Nobuo Cho、Hiroo Koyama、Kazunari Kondo、Mikihiko Naito
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06075
[Presentation] G2/M synchronization with CDK1 inhibitor suppresses genome-wide mutations and genome rearrangements during genome editing2022
- Author(s)
  Kazunari Kondo、Nozomi Fukuda、Keisuke Soga、Satoko Yoshiba、Jumpei Narushima、Norihito Shibata、Chie Taguchi、Kozue Sakata、Reiko Kato
- Organizer
  CELL BIO 2022 An ASCB EMBO Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06075
[Presentation] ゲノム編集食品の安全性評価における全ゲノムシークエンスデータを用いた解析の標準化に向けた課題2022
- Author(s)
  柴田識人、成島純平、曽我慶介、吉場聡子、近藤一成
- Organizer
  日本食品衛生学会第118回学術講演会
- Data Source
  KAKENHI-PROJECT-21K06075
[Presentation] G2/M arrest and CDK1 inhibitor treatment significantly suppress genome-wide mutations and genomic rearrangements in genome-edited cells2022
- Author(s)
  Kazunari Kondo*, Nozomi Fukuda, Keisuke Soga, Yoshiba Satoko, Jumpei Narushima, Norihito Shibata, Chie Taguchi, Kozue Sakata, Reiko Kato
- Organizer
  ASCB-EMBO joint meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02469
[Presentation] ゲノム編集におけるオフターゲット予測法SITE-SeqのGalaxyベース新規解析パイプラインの開発とその作物への応用2022
- Author(s)
  成島純平、木俣真弥、志波優、権藤崇裕、秋元智、曽我慶介、吉場聡子、中村公亮、柴田識人、近藤一成
- Organizer
  NGS EXPO 2022
- Data Source
  KAKENHI-PROJECT-21K06075
[Presentation] ゲノム編集食品における外来性遺伝子の残存を評価する全ゲノムシークエンスデータ解析の標準化に向けた取り組み2022
- Author(s)
  柴田識人、成島純平、曽我慶介、吉場聡子、近藤一成
- Organizer
  第59回全国衛生化学技術協議会年会
- Data Source
  KAKENHI-PROJECT-21K06075
[Presentation] ゲノム編集によって発生する意図しない変異はどこから来るのか2022
- Author(s)
  近藤一成、曽我慶介、成島純平、吉場聡子、柴田識人、田口千恵、坂田こずえ、加藤怜子
- Organizer
  NGS EXPO 2022
- Data Source
  KAKENHI-PROJECT-21K06075
[Presentation] 造血器型プロスタグランジンD合成酵素選択的タンパク質分解誘導剤の開発2022
- Author(s)
  柴田識人, 横尾英知, 遠藤彬則, 伊藤貴仁, 栁瀨雄太, 村上優貴, 藤井清永, 近藤一成, 佐伯泰, 内藤幹彦, 有竹浩介, 出水庸介
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K06075
[Presentation] ヒト細胞TK6を用いたCRISPR/Casによる構造変異(SV)解析の検討2021
- Author(s)
  近藤一成, 成島純平, 曽我慶介, 吉場聡子, 柴田識人, 坂田こずえ, 田口千恵, 加藤怜子
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06075
[Presentation] ゲノム編集作物におけるオフターゲット予測法の検討2021
- Author(s)
  成島純平, 木俣真弥, 志波優, 権藤崇裕, 秋元智, 曽我慶介, 吉場聡子, 中村公亮, 柴田識人, 近藤一成
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K06075
[Presentation] 造血器型プロスタグランジンD合成酵素を標的とした選択的タンパク質分解誘導剤の開発2021
- Author(s)
  柴田識人, 横尾英知, 遠藤彬則, 伊藤貴仁, 栁瀨雄太, 村上優貴, 藤井清永, 近藤一成, 佐伯泰, 内藤幹彦, 有竹浩介, 出水庸介
- Organizer
  第94回日本生化学会
- Data Source
  KAKENHI-PROJECT-21K06075
[Presentation] 造血器型プロスタグランジンD合成酵素を標的とした選択的タンパク質分解誘導剤の開発2021
- Author(s)
  柴田識人, 横尾英知, 遠藤彬則, 伊藤貴仁, 栁瀨雄太, 村上優貴, 藤井清永, 近藤一成, 佐伯泰, 内藤幹彦, 有竹浩介, 出水庸介
- Organizer
  第94回日本生化学会
- Data Source
  KAKENHI-PROJECT-18K07311
[Presentation] ヒト細胞TK6を用いたCRISPR/Casによる構造変異(SV)解析の検討2021
- Author(s)
  近藤一成、成島純平、曽我慶介、吉場聡子、柴田識人、坂田こずえ、田口千恵、加藤怜子
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02469
[Presentation] 発がん因子BCR-ABLの脱ユビキチン化は慢性骨髄性白血病細胞の増殖に必要である2020
- Author(s)
  柴田識人, 大岡伸通, 辻厳一郎, 出水庸介, 内藤幹彦
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K07311
[Presentation] 脱ユビキチン化によるがん特異的融合タンパク質の安定化2020
- Author(s)
  柴田識人, 内藤幹彦
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07311
[Presentation] A novel strategy for destabilization of oncogenic fusion protein BCR-ABL to inhibit growth of CML.2019
- Author(s)
  Shibata N, Ohoka N, Naito M
- Organizer
  5th International Symposium for Medicinal Sciences, 139th Annual Meeting of the Pharmaceutical Society of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07311
[Presentation] 脱ユビキチン化による発がん因子BCR-ABLのタンパク質安定化2019
- Author(s)
  柴田識人, 大岡伸通, 内藤幹彦
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K07311
[Presentation] 脱ユビキチン化による発がん因子BCR-ABLの安定化は慢性骨髄性白血病細胞の増殖を促進する2019
- Author(s)
  柴田識人, 大岡伸通, 内藤幹彦
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07311
[Presentation] 発がん因子BCR-ABLの分解を誘導する２つのアプローチ2019
- Author(s)
  柴田識人, 大岡伸通, 内藤幹彦
- Organizer
  第19回日本蛋白質科学会年会, 第71回日本細胞生物学会大会合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07311
[Presentation] 脱ユビキチン化によるがん特異的融合タンパク質の安定化2019
- Author(s)
  柴田識人, 大岡伸通, 築茂由則, 内藤幹彦
- Organizer
  新学術領域「ケモユビキチン」第三回班会議
- Data Source
  KAKENHI-PROJECT-18K07311
[Presentation] 発がん因子BCR-ABLのタンパク質分解誘導剤とキナーゼ阻害剤の薬理学的相違2018
- Author(s)
  柴田識人，大岡伸通，服部隆行，内藤幹彦
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07311
[Presentation] 発がん因子BCR-ABLの蛋白質分解2018
- Author(s)
  柴田　識人
- Organizer
  第２回ユビキチン研究会
- Data Source
  KAKENHI-PROJECT-18K07311
[Presentation] プロテインノックダウン法を利用したアンドロゲン受容体タンパク質分解誘導剤の開発2017
- Author(s)
  柴田識人、永井克典、森田陽子、宇治川治、大岡伸通、服部隆行、今枝泰宏、奈良洋、長展生、内藤幹彦
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26860050
[Presentation] BCR-ABLの蛋白質分解誘導剤開発を指向したBCR-ABL結合化合物の探索2016
- Author(s)
  柴田識人、大岡伸通、服部隆行、橋井則貴、斎藤臣雄、近藤恭光、石井明子、長田裕之、内藤幹彦
- Organizer
  日本薬学会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26860050
[Presentation] 発がん因子BCR-ABLを分解する低分子化合物の開発2016
- Author(s)
  柴田識人、大岡伸通、服部隆行、内藤幹彦
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26860050
[Presentation] 終止コドンリードスルー変異による蛋白質のユビキチン-プロテアソーム依存的な分解はある種の遺伝性疾患の原因となりえる2015
- Author(s)
  柴田識人、大岡伸通、権藤洋一、内藤幹彦
- Organizer
  日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26860050
[Presentation] 終止コドンのリードスルー変異によるユビキチン-プロテアソーム系を介した蛋白質の不安定化
- Author(s)
  柴田　識人、大岡伸通、権藤　洋一、内藤　幹彦
- Organizer
  日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26860050
[Presentation] 終止コドンのリードスルー変異によるユビキチン-プロテアソーム系を介した蛋白質の不安定化
- Author(s)
  柴田　識人、大岡伸通、櫻庭　喜行、権藤　洋一、内藤　幹彦
- Organizer
  日本薬学会
- Place of Presentation
  デザイン・クリエイティブセンター神戸（兵庫県）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26860050
[Presentation] 終止コドンのリードスルー変異によるユビキチン-プロテアソーム系を介した蛋白質の不安定化
- Author(s)
  柴田　識人、大岡伸通、櫻庭　喜行、権藤　洋一、内藤　幹彦
- Organizer
  Symposium for young ubiquitin researchers in Japan“New Era in the Ubiquitin Research”
- Place of Presentation
  国際高等研究所（京都府）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26860050

1. 近藤一成 (40270623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 曽我慶介 (50746336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. 為広紀正 (80597881)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. DEMIZU YOSUKE

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
5. 内藤幹彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 大岡伸通

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 服部隆行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shibata Norihito 柴田 識人

柴田 識人 シバタ ノリヒト

Research Projects

Research Products

Co-Researchers

CRISPR/Cas9による構造変異に起因した毒性の分子機構解析Principal Investigator

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Development of cell-cycle-regulated CRISPR/Cas system

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Cas9タンパク質の制御によるCRISPR/Cas9オフターゲット編集の抑制Principal Investigator

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Development of novel anti-tumor drugs targeting the stability of oncogenic fusion kinase proteinsPrincipal Investigator

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Analysis of antiviral activity of 25-hydroxycholesterolPrincipal Investigator

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新規コレステロール代謝調節機構の創薬応用の検討と本機構の持つ新たな生理意義の解明Principal Investigator

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[Journal Article] Investigation of Genetically Modified Maize Imported into Japan in 2021/2022 and the Applicability of Japanese Official Methods2023

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[Journal Article] Development of a degrader against oncogenic fusion protein FGFR3-TACC32022

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[Journal Article] Structure?activity relationship study of PROTACs against hematopoietic prostaglandin D<sub>2</sub> synthase2022

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[Journal Article] Unbiased prediction of off‐target sites in genome‐edited rice using <scp>SITE‐Seq</scp> analysis on a web‐based platform2022

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[Journal Article] Development and Validation of a New Robust Detection Method for Low-Content DNA Using ΔΔCq-Based Real-Time PCR with Optimized Standard Plasmids as a Control Sample2022

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[Journal Article] Evaluation of Conversion Factor for Rapid Quantification of Authorized Genetically Modified Maize and Soybean in Japan2022

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[Journal Article] Development of Rapid and Facile Solid‐Phase Synthesis of PROTACs via a Variety of Binding Styles2022

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[Journal Article] Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer2021

Author(s)

Shibata Norihito 柴田識人

柴田識人シバタノリヒト