OHIRA MASAHIRO 大平真裕

Researcher Number	30397947
Affiliation *help	2017 – 2018 : 広島大学, 病院(医), 助教 2016 : 広島大学, 病院(医), 病院助教 2014 – 2015 : 広島大学, 大学病院, 病院助教 2013 : 広島大学, 医歯薬保健学研究院, 特任助教
Review Section/Research Field	Principal Investigator Digestive surgery / General surgery Except Principal Investigator Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator NK細胞 / 癌免疫 / ステロイド / ＮＫ細胞 / 肝細胞癌 / エピジェネティック / 自然免疫 / TRAIL / ケモカイン / 肝切除 / 肝癌 / GITRL … More Except Principal Investigator … More

Investigation into novel mechanisms of immune-responses to anti-HLA-matched allogeneic iPS cellsOngoing
- Principal Investigator
  
  大段秀樹
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Hiroshima University
EZH2エピジェネティック制御による肝内在性NK細胞活性化機構の解明Principal InvestigatorOngoing
- Principal Investigator
  
  大平真裕
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Hiroshima University
Analysis of liver NK cell activation mechanisms through CXCL9/CXCR3 chemokine axisPrincipal Investigator
- Principal Investigator
  
  Ohira Masahiro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Hiroshima University
Analysis of cancer immune evasion through induction of steroid like agent, GITRL against NK cellsPrincipal Investigator
- Principal Investigator
  
  OHIRA MASAHIRO
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General surgery
- Research Institution
  Hiroshima University

All 2017 2016 2015

All Journal Article Presentation

[Journal Article] CD52-Negative NK Cells Are Abundant in the Liver and Less Susceptible to Alemtuzumab Treatment.2016
- Author(s)
  Hotta R, Ohira M, Matsuura T, Muraoka I, Tryphonopoulos P, Fan J, Tekin A, Selvaggi G, Levi D, Ruiz P, Ricordi C, Vianna R, Ohdan H, Waldmann H, Tzakis AG, and Nishida S.
- Journal Title
  
  PLoS One
  
  Volume : 11
- DOI
  10.1371/journal.pone.0161618
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19893
[Journal Article] Intrahepatic cholangiocarcinoma coinciding with a liver metastasis from a rectal carcinoma: a case report.2016
- Author(s)
  Akabane S, Ohira M, Kobayashi T, Kuroda S, Tanimine N, Shimizu S, Tahara H, Ide K, Ishiyama K, Egi H, Tanabe K, Sentani K, Yasui W, and Ohdan H.
- Journal Title
  
  Surg Case Rep.
  
  Volume : 2 Pages : 94-94
- DOI
  10.1186/s40792-016-0222-x
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19893, KAKENHI-PROJECT-16K08691
[Journal Article] Intraoperative assessment of tissue oxygen saturation of the remnant stomach by near-infrared spectroscopy in two cases of pancreatectomy following gastrectomy.2016
- Author(s)
  Akabane S, Ohira M, Ishiyama K, Kobayashi T, Ide K, Tahara H, Kuroda S, Tanimine N, Shimizu S, Tanabe K, and Ohdan H.
- Journal Title
  
  International journal of surgery case reports
  
  Volume : 22 Pages : 75-78
- DOI
  10.1016/j.ijscr.2016.03.047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19893
[Journal Article] Elective laparoscopic deroofing to treat the spontaneous rupture of a large simple liver cyst: a case report.2016
- Author(s)
  Imaoka Y, Ohira M, Kobayashi T, Shimizu S, Tahara H, Kuroda S, Ide K, Ishiyama K, and Ohdan H.
- Journal Title
  
  Surg Case Rep
  
  Volume : 2 Pages : 148-148
- DOI
  10.1186/s40792-016-0275-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19893
[Presentation] ドナー肝臓由来活性化ナチュラルキラー細胞移入療法による肝臓移植後重症感染症予防（第I/II相試験）2017
- Author(s)
  大平真裕矢野琢也　中野亮介　田中友加　大段秀樹
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-15K19893
[Presentation] Immunotherapy using donor liver NK cells for preventing severe infection after liver transplantation2016
- Author(s)
  大平真裕　石山宏平, 小林剛, 井手健太郎, 田原裕之, 矢野琢也, 清水誠一, 中野亮介, 大段秀樹.
- Organizer
  第71回日本消化器外科学会総会
- Place of Presentation
  徳島
- Year and Date
  2016-07-13
- Data Source
  KAKENHI-PROJECT-15K19893
[Presentation] 肝切除後肝臓癌再発における肝臓内NK細胞機能低下メカニズムの解明2016
- Author(s)
  矢野琢也　大平真裕, 中野亮介, 石山宏平, 井手健太郎, 田原裕之, 佐伯吉弘, 石田伸樹, 田中友加, 大段秀樹.
- Organizer
  第71回日本消化器外科学会総会
- Place of Presentation
  徳島
- Year and Date
  2016-07-13
- Data Source
  KAKENHI-PROJECT-15K19893
[Presentation] Reduction in CXCL9-CXCR3 signals diminishes TRAIL-expressing liver NK cells in partially hepatectomized mice under depressed immune status.2016
- Author(s)
  Yano T　Ohira M, Nakano R, Ohdan H.
- Organizer
  26th International Congress of the Transplantation Society
- Place of Presentation
  Hong Kong, China
- Year and Date
  2016-08-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19893
[Presentation] 肝移植後肝癌再発におけるNK細胞機能脆弱化のメカニズムの解明2016
- Author(s)
  矢野琢也大平真裕, 中野亮介, 石山宏平, 井手健太郎, 田原裕之, 清水誠一, 佐伯吉弘, 坂井寛, 石田伸樹, 柳川泉一郎, 田中飛鳥, 尾上隆司, 田中友加, 大段秀樹.
- Organizer
  第52回日本移植学会総会
- Place of Presentation
  東京
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-15K19893
[Presentation] Corticosteroids dampen Natural Killer cell function including cytotoxicity and anti-HCV effect2016
- Author(s)
  Masahiro Ohira　Ryuichi Hotta, Takuya Yano, Ryosuke Nakano, Andreas Tzakis, Seigo Nishida, Hideki Ohdan
- Organizer
  Asian Transplantation Week 2016
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-10-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19893
[Presentation] 肝癌再発予防のための肝切除後ケモカイン低下による肝臓内NK 細胞機能低下の解析2016
- Author(s)
  矢野琢也大平真裕, 中野亮介, 石山宏平, 井手健太郎, 田原裕之, 谷峰直樹, 佐伯吉弘, 清水誠一, 坂井寛, 広瀬貴行, 柳川泉一郎, 田中飛鳥, 田口和浩, 田中友加, 田代裕尊, 大段秀樹.
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15K19893
[Presentation] 肝臓切除後におけるNK細胞機能の脆弱化のメカニズム2016
- Author(s)
  矢野琢也　大平真裕, 中野亮介, 大段秀樹.
- Organizer
  第12回広島肝臓プロジェクト研究センター　シンポジウム
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-15K19893
[Presentation] ドナー肝臓由来活性化ナチュラルキラー細胞移入療法による肝臓移植後重症感染症予防（第I/II相試験）2016
- Author(s)
  大平真裕清水誠一, 矢野琢也, 中野亮介, 堀田龍一, 田原裕之, 井手健太郎, 小林剛, 石山宏平, 田中友加, 大段秀樹
- Organizer
  第52回日本肝臓学会総会
- Place of Presentation
  千葉
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K19893
[Presentation] Significant reduction in TRAIL-expressing NK cells in remnant liver after partial hepatectomy is strongly associated with the impaired intrahepatic CXCL9–CXCR3 pathway2015
- Author(s)
  Takuya Yano, Masahiro Ohira, Hideki Ohdan
- Organizer
  2015American Transplant Congress
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-05-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19893
[Presentation] 肝切除による肝臓内免疫機能低下メカニズムの解明と制御2015
- Author(s)
  矢野琢也、大平真裕、大段秀樹
- Organizer
  第115回日本外科学会定期学術集会
- Place of Presentation
  名古屋国際会議場、愛知県名古屋市
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-15K19893
[Presentation] 肝切除による肝臓内免疫機能低下におけるメカニズムの解明と制御2015
- Author(s)
  矢野琢也、大平真裕、大段秀樹
- Organizer
  第51回日本移植学会総会
- Place of Presentation
  ホテル日航熊本、熊本県熊本市
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-15K19893

1. 大段秀樹 (10363061)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
2. 田中友加 (90432666)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
3. 井手健太郎 (50511565)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
4. 田原裕之 (30423354)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
5. 仙谷和弘

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

OHIRA MASAHIRO 大平 真裕

Research Projects

Research Products

Co-Researchers

Investigation into novel mechanisms of immune-responses to anti-HLA-matched allogeneic iPS cellsOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

EZH2エピジェネティック制御による肝内在性NK細胞活性化機構の解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of liver NK cell activation mechanisms through CXCL9/CXCR3 chemokine axisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of cancer immune evasion through induction of steroid like agent, GITRL against NK cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] CD52-Negative NK Cells Are Abundant in the Liver and Less Susceptible to Alemtuzumab Treatment.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intrahepatic cholangiocarcinoma coinciding with a liver metastasis from a rectal carcinoma: a case report.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intraoperative assessment of tissue oxygen saturation of the remnant stomach by near-infrared spectroscopy in two cases of pancreatectomy following gastrectomy.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elective laparoscopic deroofing to treat the spontaneous rupture of a large simple liver cyst: a case report.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] ドナー肝臓由来活性化ナチュラルキラー細胞移入療法による肝臓移植後重症感染症予防（第I/II相試験）2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Immunotherapy using donor liver NK cells for preventing severe infection after liver transplantation2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 肝切除後肝臓癌再発における肝臓内NK細胞機能低下メカニズムの解明2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Reduction in CXCL9-CXCR3 signals diminishes TRAIL-expressing liver NK cells in partially hepatectomized mice under depressed immune status.2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 肝移植後肝癌再発におけるNK細胞機能脆弱化のメカニズムの解明2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Corticosteroids dampen Natural Killer cell function including cytotoxicity and anti-HCV effect2016

Author(s)

OHIRA MASAHIRO 大平真裕

[Presentation] ドナー肝臓由来活性化ナチュラルキラー細胞移入療法による肝臓移植後重症感染症予防（第I/II相試験）2016

[Presentation] Significant reduction in TRAIL-expressing NK cells in remnant liver after partial hepatectomy is strongly associated with the impaired intrahepatic CXCL9–CXCR3 pathway2015