Hoshina Takayuki 保科隆之

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HOSHINA Takayuki 保科隆之

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Researcher Number	30398078
Affiliation (Current)	2025: 地方独立行政法人福岡市立病院機構福岡市立こども病院(臨床研究部), 臨床研究部, 診療科長 2025: 産業医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2023: 産業医科大学, 医学部, 准教授 2016 – 2017: 産業医科大学, 医学部, 講師 2013 – 2015: 産業医科大学, 医学部, 助教 2011: 九州大学, 大学病院, 助教 2009 – 2011: 九州大学, 大学病院, 特任助教 2005 – 2008: 九州大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator 免疫学 / 感染症 / 宿主要因 / 遺伝子 / 感染症学 / 結合型肺炎球菌ワクチン / 小児感染症学 / サルモネラ / 小児科学 / メモリーB細胞 … More / 造血細胞移植 / 新生児 / 予防医学 / ヘルパーＴ細胞 / メモリーＢ細胞 / 免疫応答低下 / 免疫不全 / 細胞内寄生菌 … More Except Principal Investigator 小児 / 網羅的解析 / 発症病理 / 治療反応性 / 発症 / 網羅的細菌叢解析 / 腸内細菌叢 / 川崎病 / クローンライブラリー法 / 常在細菌叢 / 次世代シークエンサー / PFPA症候群 / 網羅的 / 細菌叢 / 16S ribosomal RNA / 自己炎症性疾患 / クローンライブラリー / 次世代シーケンサー / 咽頭 / PFAPA症候群 / 鑑別 / バイオマーカー / 細菌性 / 喀痰 / 肺炎 / 熱性けいんれん / 異常行動 / 熱性けいれん / 脳炎 / 予後予測 / 早期診断 / 小児期 / 急性脳症 / 多施設共同研究 / 予後 / 診断 / 脳症 / Th1 / IL-12 / IFN-γ / 宿主遺伝要因 / 易感染性 / 抗酸菌 / 副反応 / BCG / 小児感染症学 Less

Investigation on the association of intestinal flora with the pathogenesis and responsiveness to treatment in Kawasaki disease using next-generation sequencer and clone library analysis
- Principal Investigator
  
  楠原浩一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  University of Occupational and Environmental Health, Japan
Investigation on pharyngeal bacterial flora in patients with PFAPA syndrome using next-generation sequencer and clone library analysis
- Principal Investigator
  
  Kusuhara Koichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  University of Occupational and Environmental Health, Japan
Early prediction of children with lower response to pneumococcal conjugate vaccinePrincipal Investigator
- Principal Investigator
  
  Hoshina Takayuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  University of Occupational and Environmental Health, Japan
Detection of microbiological aspects in the development of chronic lung disease in premature infants and prevention strategies of the diseasePrincipal Investigator
- Principal Investigator
  
  Hoshina Takayuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Occupational and Environmental Health, Japan
Search for biomarkers useful for discriminating bacterial pneumonia in children
- Principal Investigator
  
  KUSUHARA Koichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Occupational and Environmental Health, Japan
Analysis of the factor of low immune responses to pneumococcal conjugate vaccine and Hemophilus influenzae type b conjugate vaccine in immunocompromised childrenPrincipal Investigator
- Principal Investigator
  
  HOSHINA Takayuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Occupational and Environmental Health, Japan
Clinical and host genetic characteristics of patients susceptible to intracellular bacterial pathogens in Japan.Principal Investigator
- Principal Investigator
  
  HOSHINA Takayuki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kyushu University
A multicenter study on early diagnosis and prognostic prediction of acute encephalopathy in childhood
- Principal Investigator
  
  KUSUHARA Koichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Occupational and Environmental Health, Japan
Search for genetic factors that confer susceptibility to severe BCG infection and other mycobacterial diseases in Japanese
- Principal Investigator
  
  SASAKI Yuka
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kyushu University
Clarification of condition of salmonella infectious disease appearance of disease and relating landlord inheritance factorPrincipal Investigator
- Principal Investigator
  
  HOSHINA Takayuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kyushu University
サルモネラ感染症発症に関連する宿主遺伝要因の解明Principal Investigator
- Principal Investigator
  
  保科隆之
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kyushu University

[Book] 小児科診療(小児の治療指針)2014
- Author(s)
  保科隆之、高田英俊
- Total Pages
  3
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-25461598
[Journal Article] Environmental factors related to differences in the microbiota in the upper respiratory tract in young children: Focusing on the impact of early nursery attendance.2023
- Author(s)
  Abushawish A, Haro K, Hoshina T, Kitajima N, Kusuhara K.
- Journal Title
  
  Front Pediatr
  
  Volume: 11 Pages: 1015872-1015872
- DOI
  10.3389/fped.2023.1015872
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08173, KAKENHI-PROJECT-23K07324
[Journal Article] Evaluation of the usefulness of culture of induced sputum and the optimal timing for the collection of a good-quality sputum sample to identify causative pathogen of community-acquired pneumonia in young children: A prospective observational study.2023
- Author(s)
  Ogawa M, Hoshina T, Abushawish A, Kusuhara K.
- Journal Title
  
  J Microbiol Immunol Infect
  
  Volume: 56 Issue: 5 Pages: 1036-1044
- DOI
  10.1016/j.jmii.2023.05.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07324
[Journal Article] A pediatric case of previously unrecognized Streptococcus periodonticum -associated meningitis after cranial surgery.2023
- Author(s)
  Nagashio H, Yoneda T, Hoshina T, Saito R, Kusuhara K
- Journal Title
  
  Pediatr Infect Dis J
  
  Volume: 42 Issue: 3 Pages: e99-e100
- DOI
  10.1097/inf.0000000000003787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08173
[Journal Article] Usefulness of cervical computed tomography hounsfield units to differentiate Kawasaki disease from a deep-neck abscess.2023
- Author(s)
  Ogawa M, Matsuki Y, Hoshina T, Kojiro M, Kusuhara K.
- Journal Title
  
  Pediatr Infect Dis J
  
  Volume: 42 Issue: 2 Pages: e50-e51
- DOI
  10.1097/inf.0000000000003761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08173
[Journal Article] Systemic corticosteroid as an adjunctive treatment for lower respiratory tract infection in children with severe motor and intellectual disabilities2022
- Author(s)
  Nakamoto Takato、Hoshina Takayuki、Ishii Masahiro、Yamada Gen、Kusuhara Koichi
- Journal Title
  
  Journal of Infection and Chemotherapy
  
  Volume: 28 Issue: 3 Pages: 384-388
- DOI
  10.1016/j.jiac.2021.11.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08333, KAKENHI-PROJECT-20K08173
[Journal Article] The possible association between epidemics of hand-foot-and-mouth disease and responsiveness to immunoglobulin therapy in Kawasaki disease.2022
- Author(s)
  Shimizu D, Hoshina T, Kawamura M, Tomita Y, Hidaka Y, Kojiro M, Muneuchi J, Kamizono J, Yamaguchi K, Fujino Y, Kusuhara K.
- Journal Title
  
  Front Pediatr
  
  Volume: 10 Pages: 968857-968857
- DOI
  10.3389/fped.2022.968857
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08173
[Journal Article] Trends in voluntary vaccination coverage in a Japanese city2021
- Author(s)
  Hoshina Takayuki、Kawase Mayumi、Watanabe Shunsuke、Shibahara Junpei、Kojiro Masumi、Miyake Takumi、Sakaguchi Yusuke、Kajiwara Yasuhiro、Kusuhara Koichi
- Journal Title
  
  Pediatrics International
  
  Volume: 63 Issue: 12 Pages: 1466-1471
- DOI
  10.1111/ped.14712
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08333, KAKENHI-PROJECT-20K08173
[Journal Article] The recent characteristics of influenza-related hospitalization in Japanese children.2021
- Author(s)
  Watanabe S, Hoshina T, Kojiro M, Kusuhara K.
- Journal Title
  
  Eur J Clin Microbiol Infect Dis
  
  Volume: 40 Issue: 9 Pages: 2011-2015
- DOI
  10.1007/s10096-021-04208-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08173
[Journal Article] Impaired B-Cell Differentiation in a Patient With STAT1 Gain-of-Function Mutation.2020
- Author(s)
  Nemoto K, Kawanami T, Hoshina T, Ishimura M, Yamasaki K, Okada S, Kanegane H, Yatera K, Kusuhara K.
- Journal Title
  
  Front Immunol
  
  Volume: 11 Pages: 557521-557521
- DOI
  10.3389/fimmu.2020.557521
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08173, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-18KK0228
[Journal Article] A survey of the implementation status of selected infection control strategies in neonatal intensive care units in Japan.2020
- Author(s)
  Suga S, Hoshina T, Ichikawa S, Araki S, Kusuhara K.
- Journal Title
  
  J Hosp Infect
  
  Volume: 2020 Issue: 2 Pages: 200-206
- DOI
  10.1016/j.jhin.2019.09.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08173
[Journal Article] Reduction in the Number of Varicella-Zoster Virus-Specific T-Cells in Immunocompromised Children with Varicella2020
- Author(s)
  Murata K, Hoshina T, Onoyama S, Tanaka T, Kanno S, Ishimura M, Koga Y, Nakayama H, Ohga S
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 250 Issue: 3 Pages: 181-190
- DOI
  10.1620/tjem.250.181
- NAID
  130007814974
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08333
[Journal Article] The optimal duration of antimicrobial therapy for lower respiratory tract infection in patients with neuromuscular disorders based on a clone library analysis of the bacterial 16S rRNA gene sequence.2020
- Author(s)
  Kawamura M, Hoshina T, Ogawa M, Yamamoto N, Haro K, Kumadaki T, Fukuda K, Kusuhara K
- Journal Title
  
  International Journal of Infectious Diseases
  
  Volume: 100 Pages: 396-401
- DOI
  10.1016/j.ijid.2020.09.035
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08333, KAKENHI-PROJECT-20K08173
[Journal Article] Chronic mandibular osteomyelitis caused by Granulicatella adiacens in an immunocompetent child2019
- Author(s)
  Mizuki Kazuyoshi、Morita Hiromi、Hoshina Takayuki、Taku Keisuke、Oshida Koichi、Honda Yuko、Miyawaki Akihiko、Oya Ryoichi、Kusuhara Koichi
- Journal Title
  
  Journal of Infection and Chemotherapy
  
  Volume: 25 Issue: 5 Pages: 376-378
- DOI
  10.1016/j.jiac.2018.12.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10049
[Journal Article] The microbiological characteristics of lower respiratory tract infection in patients with neuromuscular disorders: An investigation based on a multiplex polymerase chain reaction to detect viruses and a clone library analysis of the bacterial 16S rRNA gene sequence in sputum samples2019
- Author(s)
  Ogawa Masato、Hoshina Takayuki、Haro Kaoru、Kumadaki Tokiko、Ishii Masahiro、Fujino Yoshihisa、Fukuda Kazumasa、Kusuhara Koichi
- Journal Title
  
  Journal of Microbiology, Immunology and Infection
  
  Volume: 印刷中 Issue: 5 Pages: 827-830
- DOI
  10.1016/j.jmii.2019.01.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10049
[Journal Article] Effectiveness of an early switch from intravenous to oral antimicrobial therapy for lower respiratory tract infection in patients with severe motor intellectual disabilities.2018
- Author(s)
  Kawamura M, Hoshina T, Ogawa M, Nakamoto T, Kusuhara K.
- Journal Title
  
  J Infect Chemother
  
  Volume: 24 Issue: 1 Pages: 40-44
- DOI
  10.1016/j.jiac.2017.08.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09673
[Journal Article] Utility of the Performance of Lumbar Puncture for Febrile Children with Status Epilepticus in the Bacterial Conjugate Vaccine Era.2018
- Author(s)
  Kaoru H, Igarashi R, Hoshina T, Kojiro M, Kusuhara K.
- Journal Title
  
  Pediatr Infect Dis J
  
  Volume: 印刷中 Issue: 10 Pages: 963-966
- DOI
  10.1097/inf.0000000000001945
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09673
[Journal Article] Efficacy of periodic surveillance culture in a neonatal intensive care unit in the presumption of causative pathogens of late-onset bacterial infection.2017
- Author(s)
  Ichikawa S, Hoshina T, Kinjo T, Araki S, Kusuhara K
- Journal Title
  
  Am J Infect Control
  
  Volume: 45 Issue: 3 Pages: 251-254
- DOI
  10.1016/j.ajic.2016.09.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09673, KAKENHI-PROJECT-16K10049, KAKENHI-PROJECT-16K10115
[Journal Article] Difference between Japanese Secondary and Tertiary Medical Facilities Regarding Changes in the Hospitalization of Children for Pneumonia after the Introduction of the Pneumococcal Conjugate Vaccine.2017
- Author(s)
  Haro K, Ogawa M, Hoshina T, Kojiro M, Kusuhara K.
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 70 Pages: 270-274
- NAID
  130005671856
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09673
[Journal Article] The efficacy of the direct clinical intervention for infectious diseases by a pediatric infectious disease specialist in the pediatric ward of a tertiary medical facility without a pediatric antimicrobial stewardship program.2017
- Author(s)
  Hoshina T, Yamamoto N, Ogawa M, Nakamoto T, Kusuhara K.
- Journal Title
  
  Eur J Clin Microbiol Infect Dis
  
  Volume: 36 Issue: 8 Pages: 1449-1454
- DOI
  10.1007/s10096-017-2952-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09673
[Journal Article] An infant case with hydrocephalus as the initial manifestation of Mycoplasma hominis-associated meningitis.2017
- Author(s)
  Taku K, Hoshina T, Haro K, Ichikawa S, Kinjo T, Takahashi M, Akiba D, Fukuda K, Kusuhara K.
- Journal Title
  
  Journal of Infection and Chemotherapy
  
  Volume: 23 Issue: 10 Pages: 713-716
- DOI
  10.1016/j.jiac.2017.03.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10049
[Journal Article] Difference of the change of the hospitalization for pneumonia in children between Japanese secondary and tertiary medical facilities after the introduction of pneumococcal conjugate vaccine.2017
- Author(s)
  Haro K, Ogawa M, Hoshina T, Kojiro M, Kusuhara K
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09673
[Journal Article] Memory B-ｃell ｐools ｐredict the immune response to pneumococcal conjugate vaccine in immunocompromised children2016
- Author(s)
  Takayuki Hoshina, Shouichi Ohga, Junko Fujiyoshi, Etsuro Nanishi, Tomoko Takimoto, Shunsuke Kanno, Hisanori Nishio, Mitsumasa Saito, Yukihiko Akeda, Kazunori Oishi, Toshiro Hara
- Journal Title
  
  Journal of Infectious Diseases
  
  Volume: 213 Issue: 5 Pages: 848-855
- DOI
  10.1093/infdis/jiv469
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461598
[Journal Article] Serial Changes of Serum Cytokine in a Pediatric Patient with Severe Fever with Thrombocytopenia Syndrome.2016
- Author(s)
  Kawase M, Hoshina T, Nakamoto T, Asai H, Ishii M, Kusuhara K.
- Journal Title
  
  Pediatr Infect Dis J
  
  Volume: 35 Issue: 3 Pages: 359-360
- DOI
  10.1097/inf.0000000000001005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09673
[Journal Article] Analysis of the Physiological Variation in Neutrophil CD64 Expression during the Early Neonatal Period.2016
- Author(s)
  Miyake F, Ishii M, Hoshina T, Ichikawa S, Araki S, Kinjo T, Shibata E, Hachisuga T, Kusuhara K
- Journal Title
  
  Am J Perinatol
  
  Volume: 33 Pages: 1377-1381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09673
[Journal Article] The uselessness of procalcitonin in the diagnosis of focal bacterial central nervous system infection.2015
- Author(s)
  Hoshina T, Takimoto T, Nanishi E, Nishio H, Kusuhara K, Hara T.
- Journal Title
  
  J Infect Chemother
  
  Volume: 21 Issue: 8 Pages: 620-622
- DOI
  10.1016/j.jiac.2015.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09673
[Journal Article] Utility of ferritin as a predictor of the patients with Kawasaki disease refractory to intravenous immunoglobulin therapy.2015
- Author(s)
  Yamamoto N, Sato K, Hoshina T, Kojiro M, Kusuhara K.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 25 Issue: 6 Pages: 898-902
- DOI
  10.3109/14397595.2015.1038430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09673
[Journal Article] The utility of biomarkers in differentiating bacterial from non-bacterial lower respiratory tract infection in hospitalized children: difference of the diagnostic performance between acute pneumonia and bronchitis.2014
- Author(s)
  Hoshina T, Nanishi E, Kanno S, Nishio H, Kusuhara K, Hara T
- Journal Title
  
  J Infect Chemother
  
  Volume: 20 Issue: 10 Pages: 616-620
- DOI
  10.1016/j.jiac.2014.06.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591564, KAKENHI-PROJECT-25461598
[Journal Article] Clinical and host genetic characteristics of Mendelian susceptibility to mycobacterial diseases in Japan2011
- Author(s)
  Hoshina T, Takada H, Sasaki-Mihara Y, Kusuhara K, Ohshima K, Okada S, Kobayashi M, Ohara O, Hara T
- Journal Title
  
  J Clin Immunol
  
  Volume: 31 Pages: 309-314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591389
[Journal Article] Systemic cytokine response in moribund mice of streptococcal toxic shock syndrome model2011
- Author(s)
  Saito M, Kajiwara H, Iida K, Hoshina T, Kusuhara K, Hara T, Yoshida S
- Journal Title
  
  Microb Pathog
  
  Volume: 50 Pages: 109-113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591389
[Journal Article] Clinical and host genetic characteristics of Mendelian susceptibility to mycobacterial diseases in Japan2011
- Author(s)
  Hoshina T, Takada H, Sasaki-Mihara Y, Kusuhara K, Ohshima K, Okada S, Kobayashi M, Ohara O, Hara T
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 31(3) Pages: 309-314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790987
[Journal Article] BCG骨髄炎27例の検討2011
- Author(s)
  保科隆之, ほか
- Journal Title
  
  小児感染免疫
  
  Volume: 23 Pages: 227-232
- NAID
  10029704966
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790987
[Journal Article] Clinical and host genetic characteristics of Mendelian susceptibility to mycobacterial diseases in Japan2011
- Author(s)
  Hoshina T, Takada H, et al
- Journal Title
  
  J Clin Immunol
  
  Volume: 31 Issue: 3 Pages: 309-314
- DOI
  10.1007/s10875-010-9498-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591363, KAKENHI-PROJECT-22790987, KAKENHI-PROJECT-23591559, KAKENHI-PROJECT-23591561
[Journal Article] BCG骨髄炎27例の検討2011
- Author(s)
  保科隆之、高田英俊、佐々木由佳、楠原浩一、原寿郎
- Journal Title
  
  小児感染免疫
  
  Volume: 23(3) Pages: 227-232
- NAID
  10029704966
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790987
[Journal Article] Clinical and host genetic characteristics of Mendelian susceptibility to mycobacterial diseases in Japan2011
- Author(s)
  Hoshina T, et al.
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790987
[Journal Article] Systemic cytokine response in moribund mice of streptococcal toxic shock syndrome model2011
- Author(s)
  Saito M, Kajiwara H, Iida K, Hoshina T, Kusuhara K, Hara T, Yoshida S
- Journal Title
  
  Microbial Pathogenesis
  
  Volume: 50(2) Pages: 109-113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790987
[Journal Article] Identification of bacterial pathogens in pediatric community-acquired lower respiratory tract infection using a simplified procedure of sputum sampling and examination : comparison between hospitalized children with and without underlying diseases2010
- Author(s)
  Hoshina T, Kusuhara K, Takimoto T, Saito M, Hara T
- Journal Title
  
  European Journal of Clinical Microbiology & Infectious Diseases
  
  Volume: 29(5) Pages: 519-525
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790987
[Journal Article] Identification of bacterial pathogens in pediatric community-acquired lower respiratory tract infection using a simplified procedure of sputum sampling and examination : comparison between hospitalized children with and without underlying diseases.2010
- Author(s)
  Hoshina T, Kusuhara K, Takimoto T, et al.
- Journal Title
  
  Eur J Clin Microbiol Infect Dis
  
  Volume: 29 Pages: 519-525
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591389
[Journal Article] Identificatio n of bacterial pathogens in pediatric community-acquired lower respiratory tract infection using a simplified procedure of sputum sampling and examination : comparison between hospitalized children with and without underlying diseases2010
- Author(s)
  Hoshina T, Kusuhara K, Takimoto T, Saito M, Hara T
- Journal Title
  
  Eur J Clin Microbiol Infect Dis
  
  Volume: 29 Pages: 519-525
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591389
[Journal Article] Toxic shock syndrome-like exanthematous disease in a 2-month-old infant2010
- Author(s)
  Inoue H, Hoshina T, Kinjo T, Saito M, Kusuhara K, Hara T
- Journal Title
  
  Pediatr Int
  
  Volume: 52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591389
[Journal Article] Toxic shock syndrome-like exanthematous disease in a 2-month-old infant.2010
- Author(s)
  Inoue H, Hoshina T, Kinjo T, et al.
- Journal Title
  
  Pediatr Int
  
  Volume: 52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591389
[Journal Article] Cytomegalovirus-associated protein-losing enteropathy resulting from lymphangiectasia in an immunocompetent child.2009
- Author(s)
  Hoshina T, Kusuhara K, Saito M, et al.
- Journal Title
  
  Jpn J Infect Dis 62
  
  Pages: 236-238
- NAID
  40016584029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591389
[Journal Article] Disseminated Bacillus Calmette-Guerin lymphadenitis in a patient with gp91phox- chronic granulomatous disease 25 years after vaccination.2009
- Author(s)
  Kusuhara K, Ohga S, Hoshina T, et al.
- Journal Title
  
  Eur J Pediatr 168
  
  Pages: 745-747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591389
[Journal Article] Disseminated Bacillus Calmette-Guerin lymphadenitis in a patient with gp91phox(-) chronic granulomatous disease 25 years after vaccination2009
- Author(s)
  Kusuhara K, Ohga O, Hoshina T, Saito M, Sasaki Y, Ishimura M, Takada H, Fujita M, Hara T
- Journal Title
  
  Eur J Pediatr
  
  Volume: 168 Pages: 745-744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591389
[Journal Article] Cytomegalovirus-associated protein-losing enteropathy resulting from lymphangiectasia in an immunocompetent child2009
- Author(s)
  Hoshina T, Kusuhara K, Saito M, Hara T, Mtsuura S, Yano T, Aoki T, Hara T
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 62 Pages: 236-238
- NAID
  40016584029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591389
[Journal Article] Infected subdural hematoma in an infant2008
- Author(s)
  Hoshina T, Kusuhara K, Saito M, et.al.
- Journal Title
  
  Japanese Journal of Infectious Diseases 61
  
  Pages: 412-414
- NAID
  40016249994
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790727
[Journal Article] Disseminated Bacillus Calmette-Guerin lymph-adenitis in a patient with gp91phox (-) chronic granulomatous disease 25 years after vaccination2008
- Author(s)
  Kusuhara K, Ohga O, Hoshina T, Saito M, Sasaki Y, Ishimura M, Takada H, Fujita M, Hara T
- Journal Title
  
  Eur J Pediatr (Epub ahead of print)
- Data Source
  KAKENHI-PROJECT-19591254
[Journal Article] Sjogren's syndrome-associated meningoencephalomyelitis: Cerebrospinal ffluid cytokine levels and therapeutic utility of tacrolimus2008
- Author(s)
  Hoshina, T, Yamaguchi, Y, Ohga, S, et. al.
- Journal Title
  
  Journal of the Neurological Sciences 267
  
  Pages: 182-186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790727
[Journal Article] Sjogren's syndrome-associated meningoencephalomyelitis: cerebrospinal fluid cytokine levels and therapeutic utility of tacrolimus2008
- Author(s)
  Hoshina T, Yamaguchi Y, Ohga S, Kira R, Ishimura M, Takada H, Tanaka T, Hara T
- Journal Title
  
  Journal of the Neurological Sciences 267(1-2)
  
  Pages: 182-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790727
[Journal Article] Infected subdural hematoma in an infant2008
- Author(s)
  Hoshina T, Kusuhara K, Saito M, Mizoguchi M, Morioka T, Mizuno Y, Aoki T, Hara T
- Journal Title
  
  Japanese Journal of Infectious Diseases 61(5)
  
  Pages: 412-4
- NAID
  40016249994
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790727
[Journal Article] High mobility group box 1 (HMGB1) and macrophage migration inhibitory factor (MIF) in Kawasaki disease2008
- Author(s)
  Hoshina T, Kusuhara K, Ikeda K, Mizuno Y, Saito M, Hara T
- Journal Title
  
  Scandinavian Journal of Rheumatology 37(6)
  
  Pages: 445-449
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790727
[Journal Article] Disseminated Bacillus Calmette-Guerin lymphadenitis in a patient with gp91phox(-)chronic granulomatous disease 25 years after vaccination.2008
- Author(s)
  Kusuhara K, Ohga S, Hoshina T, Saito M, Sasaki Y, et al.
- Journal Title
  
  Eur J Pediatr Epub ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591254
[Journal Article] High mobility group box 1 (HMGB1) and macrophage migration inhibitory factor (MIF) in Kawasaki disease2008
- Author(s)
  Hoshina T, Kusuhara K, Ikeda K, Mizuno Y, Saito M, Hara T
- Journal Title
  
  Scand J Rheumatol 37
  
  Pages: 445-9
- Data Source
  KAKENHI-PROJECT-19591254
[Journal Article] High mobility group box 1 (HMGBI) and macrophage migration inhibitory factor (MIF) in Kawasaki disease2008
- Author(s)
  Hoshina T, Kusuhara K, Ikeda K, et.al.
- Journal Title
  
  Scandinavian Journal of Rheumatology 37
  
  Pages: 445-449
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790727
[Journal Article] High mobility group box 1 (HMGB1)and macrophage migration inhibitory factor (MIF) in Kawasaki disease.2008
- Author(s)
  Hoshina T, Kusuhara K, et al.
- Journal Title
  
  Scand J Rheumatol 37(6)
  
  Pages: 445-449
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591254
[Presentation] 川崎病発症および治療反応性と腸内細菌叢との関連についての検討2023
- Author(s)
  小川将人, 保科隆之, 石井雅宏, 神代万壽美, 中林武尊, 田中耕生, 紙田正博, 楠原浩一.
- Organizer
  第55回日本小児感染症学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K07324
[Presentation] Environmental factors changing upper respiratory tract microbiome in young children.2022
- Author(s)
  Abushawish A, Haro K, Hoshina T, Kitajima N, Kusuhara K.
- Organizer
  第54回日本小児感染症学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K08173
[Presentation] 出生直後の胃液の網羅的細菌叢解析結果と早産児の慢性肺疾患進展との関連性の検討2017
- Author(s)
  波呂　薫、保科隆之、齋藤光正、楠原浩一
- Organizer
  第49回日本小児感染症学会
- Data Source
  KAKENHI-PROJECT-16K10049
[Presentation] 免疫不全小児の結合型肺炎球菌ワクチンに対する免疫応答低下の要因の検討2015
- Author(s)
  保科隆之、大賀正一、名西悦郎、神野俊介、西尾壽乗、齋藤光正、原寿郎
- Organizer
  第47回日本小児感染症学会総会・学術集会
- Place of Presentation
  ザ・セレクトン福島（福島市）
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-25461598
[Presentation] Mendelian susceptibility to mycobacterial diseasesの日本における臨床像および遺伝的背景の検討2011
- Author(s)
  保科隆之、高田英俊、三原由佳、楠原浩一、岡田賢、小林正夫、原寿郎
- Organizer
  第64回九州小児科学会
- Place of Presentation
  佐賀
- Data Source
  KAKENHI-PROJECT-22790987
[Presentation] Mendelian susceptibility to mycobacterial diseases 46例の検討2011
- Author(s)
  保科隆之、高田英俊、三原由佳、楠原浩一、岡田賢、小林正夫、原寿郎
- Organizer
  第114回日本小児科学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22790987
[Presentation] Disseminated Bacillus Calmette-Guerin lymphadenitis in a patient with gp91phox chronic granulomatous disease 25 years after vaccination2010
- Author(s)
  Hoshina T, Ohga S, Kusuhara K, Saito M, Hara T
- Organizer
  The 6th Congress of Asian Society for Pediatric Research
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-22790987
[Presentation] Mendelian susceptibility to mycobacterial diseases 46例の検討2010
- Author(s)
  保科隆之、三原由佳、楠原浩一、原寿郎
- Organizer
  第84回日本感染症学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22790987
[Presentation] High mobility group box 1(HMGB1) and macrophage migration inhibitory factor(MIF) in Kawasaki disease2010
- Author(s)
  Hoshina T, Kusuhara K, Ikeda K, Mizuno Y, Saito M, Hara T
- Organizer
  The 6th Congress of Asian Society for Pediatric Research
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-22790987
[Presentation] 慢性肉芽腫症症例に対する播種性BCG感染症を中心とした抗酸菌感染症治療指針作成の提案2010
- Author(s)
  保科隆之、土居岳彦、瀧本智仁、高田英俊、大賀正一、原寿郎、水上智之
- Organizer
  第18回食細胞機能異常研究会
- Place of Presentation
  東京
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-22790987
[Presentation] Identification of bacterial pathogens in pediatric community-acquired lower respiratory tract infection using a simplified procedure of sputum sampling and examination : comparison between hospitalized children with and without underlying diseases2010
- Author(s)
  Hoshina T, Kusuhara K, Saito M, Hara T
- Organizer
  The 6th Congress of Asian Society for Pediatric Research
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-22790987
[Presentation] BCG接種後20年以上を経てBCGリンパ節炎を発症した慢性肉芽腫症の1例2008
- Author(s)
  楠原浩一, 保科隆之, ほか
- Organizer
  第82回日本感染症学会
- Place of Presentation
  松江市
- Year and Date
  2008-04-18
- Data Source
  KAKENHI-PROJECT-19591254
[Presentation] BCG 接種後20年以上を経てBCGリンパ節炎を発症した慢性肉芽腫症の1例2008
- Author(s)
  楠原浩一、保科隆之、齋藤光正、大賀正一、原寿郎
- Organizer
  第82回日本感染症学会
- Place of Presentation
  松江
- Data Source
  KAKENHI-PROJECT-19591254
[Presentation] サルモネラ感染症に対するγδT細胞の役割の検討-オリゴヌクレオチドマイクロアレイを用いたγδT細胞表面の分子発現の検討2008
- Author(s)
  保科隆之
- Organizer
  第40回日本小児感染症学会
- Place of Presentation
  名古屋
- Year and Date
  2008-11-16
- Data Source
  KAKENHI-PROJECT-19790727
[Presentation] BCG接種後20年以上を経てBCGリンパ節炎を発症した慢性肉芽腫症の1例2007
- Author(s)
  楠原浩一、保科隆之, ほか
- Organizer
  第39回日本小児感染症学会総会
- Place of Presentation
  横浜市
- Year and Date
  2007-11-10
- Data Source
  KAKENHI-PROJECT-19591254

1. KUSUHARA Koichi (20243941)

# of Collaborated Projects: 5 results

# of Collaborated Products: 37 results
2. 小川将人 (80566414)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. SASAKI Yuka (00444810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. TAKADA Hidetoshi (70294931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. SHIMONO Masayuki (00248569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. INOUE Hirosuke (90467902)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. YAMAGUCHI Seiji (60144044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YOSHIKAWA Tetsushi (80288472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ICHIYAMA Takashi (20263767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHIMAKAWA Shuichi (40465620)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NISHIO Hisanori (00507783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. OHGA Shiouichi (60233053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. OISHI Kazunori (80160414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. KAMIZONO Junji (50299616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MIYAKAWA Takayuki (90219733)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. FUKUDA Kazumasa (40389424)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. 石井雅宏 (30461560)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. 本村良知 (10737175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 清水大輔 (20644363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 米田哲 (10405251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hoshina Takayuki 保科 隆之

HOSHINA Takayuki 保科 隆之

Research Projects

Research Products

Co-Researchers

Investigation on the association of intestinal flora with the pathogenesis and responsiveness to treatment in Kawasaki disease using next-generation sequencer and clone library analysis

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Investigation on pharyngeal bacterial flora in patients with PFAPA syndrome using next-generation sequencer and clone library analysis

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Early prediction of children with lower response to pneumococcal conjugate vaccinePrincipal Investigator

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Detection of microbiological aspects in the development of chronic lung disease in premature infants and prevention strategies of the diseasePrincipal Investigator

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Search for biomarkers useful for discriminating bacterial pneumonia in children

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Analysis of the factor of low immune responses to pneumococcal conjugate vaccine and Hemophilus influenzae type b conjugate vaccine in immunocompromised childrenPrincipal Investigator

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Clinical and host genetic characteristics of patients susceptible to intracellular bacterial pathogens in Japan.Principal Investigator

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A multicenter study on early diagnosis and prognostic prediction of acute encephalopathy in childhood

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Search for genetic factors that confer susceptibility to severe BCG infection and other mycobacterial diseases in Japanese

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Clarification of condition of salmonella infectious disease appearance of disease and relating landlord inheritance factorPrincipal Investigator

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サルモネラ感染症発症に関連する宿主遺伝要因の解明Principal Investigator

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[Book] 小児科診療(小児の治療指針)2014

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[Journal Article] Environmental factors related to differences in the microbiota in the upper respiratory tract in young children: Focusing on the impact of early nursery attendance.2023

Author(s)

Journal Title

DOI

Hoshina Takayuki 保科隆之

HOSHINA Takayuki 保科隆之