Akashi Makoto 明石真

… Alternative Names

AKASHI Makoto 明石真

明石真アカシマコト

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Researcher Number	30398119
Other IDs
Affiliation (Current)	2025: 山口大学, 時間学研究所, 教授
Affiliation (based on the past Project Information) *help	2025: 山口大学, 時間学研究所, 教授 2014 – 2022: 山口大学, 時間学研究所, 教授 2011: Yamaguchi University, 教授 2008: 佐賀大学, 医学部, 助教 2006 – 2007: Saga University, Faculty of Medicine, Instructor, 医学部, 寄附講座教員 2005 – 2006: 佐賀大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related / Psychiatric science / Environmental physiology (including Physical medicine and Nutritional physiology) Except Principal Investigator Circulatory organs internal medicine / Basic Section 90130:Medical systems-related / Biomedical engineering/Biomaterial science and engineering / Animal physiology/Animal behavior / Environmental physiology (including Physical medicine and Nutritional physiology)
Keywords	Principal Investigator 概日時計 / 時計遺伝子 / 概日リズム / Cryptochrome / Period / 行動概日リズム / 認知症 / 睡眠障害 / 睡眠 Except Principal Investigator atherosclerosis … More / 循環器・高血圧 / 微細加工 / 精密操作 / 細胞組織 / 内視鏡 / カテーテル / RNA / 吸引 / 発現状況 / MEMS技術 / 細胞操作 / 細胞採取 / 皮膚 / 鉗子 / 低侵襲 / タンパク質 / 粘膜 / 切離 / 細胞 / 生体制御治療 / 生体制御・治療 / リアルタイム測定 / 潮汐リズム / ハムスター / ミナミコメツキガニ / 深層学習 / 概潮汐リズム / 概日リズム / 画像処理 / インターネット / 動物行動 / cvtokine / inflammation / cardiovascular disease / サイトカイン / 炎症 / 動脈硬化 / endothelial cell / endothelial function / 脂質 / 血管内皮機能 / ゲノム多型 / 慢性心不全 / バイオマーカー / コホート研究 / 急性冠症候群 / 循環器病 / 生活習慣 / 体内リズム / 運動 / 時計遺伝子 / リズム同調 / アストロサイト / 視交叉上核 / レンチウイルス / 体内時計 / 生体リズム Less

白色脂肪組織による哺乳類冬眠制御の分子メカニズムPrincipal Investigator
- Principal Investigator
  
  明石真
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related
- Research Institution
  Yamaguchi University
概日時計の転写フィードバック中枢振動体を補償するメカニズムの解明Principal Investigator
- Principal Investigator
  
  明石真
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related
- Research Institution
  Yamaguchi University
Development of technologies for precise manipulation of cell and tissue in the body
- Principal Investigator
  
  Haga Yoichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90130:Medical systems-related
- Research Institution
  Tohoku University
The role of cell-autonomous circadian oscillation of clock gene transcription in circadian rhythm generationPrincipal Investigator
- Principal Investigator
  
  Akashi Makoto
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related
- Research Institution
  Yamaguchi University
Global scale measurement and analysis of animal behavior with environmental factors through the internet
- Principal Investigator
  
  Matsuno Hiroshi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Animal physiology/Animal behavior
- Research Institution
  Yamaguchi University
Functional assessment of the circadian clock of patients with neurodegenerative disorders based on clock gene expressionPrincipal Investigator
- Principal Investigator
  
  Akashi Makoto
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  Yamaguchi University
Development of a detection method for circadian rhythm sleep disorders based on clock gene expressionPrincipal Investigator
- Principal Investigator
  
  Akashi Makoto
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  Yamaguchi University
A Novel Therapy with Bright Light System in Parkinson's Disease
- Principal Investigator
  
  ENDO TAKUYUKI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Toneyama National Hospital
The role of clock gene in cardiovascular disease
- Principal Investigator
  
  NODE Koichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Saga University
概日時計構成因子Periodの機能解析Principal Investigator
- Principal Investigator
  
  明石真
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  Yamaguchi University
Analyses of molecular mechanisms underlying circadian rhythm generation and synchronization by rapid and efficient gene transduction in vivo
- Principal Investigator
  
  HAYASAKA Naoto
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  Kinki University
The role of EET in cardiovascular disease.
- Principal Investigator
  
  NODE Koichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Saga University
Involvement of WSX-1 in atherosclerosis
- Principal Investigator
  
  HIRASE Tetsuaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Saga University

All 2022 2019 2018 2017 2016 2015 2014 2013 2012 2008

All Journal Article Presentation Book

[Book] ヒトの概日時計と時間2019
- Author(s)
  山口大学時間学研究所、時間学の構築編集委員会、明石真
- Total Pages
  196
- Publisher
  恒星社厚生閣
- ISBN
  4769916329
- Data Source
  KAKENHI-PROJECT-19K06769
[Book] 実験医学増刊号2016
- Author(s)
  明石　真
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-16K15562
[Book] New Diet Therapy2016
- Author(s)
  明石　真
- Total Pages
  6
- Publisher
  日本臨床栄養協会
- Data Source
  KAKENHI-PROJECT-26670543
[Book] 生体の科学2016
- Author(s)
  明石　真
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-16K15562
[Book] 時間学研究2015
- Author(s)
  野村直樹、橋元淳一郎、明石　真
- Total Pages
  14
- Publisher
  日本時間学会
- Data Source
  KAKENHI-PROJECT-26670543
[Book] 医学のあゆみ2015
- Author(s)
  明石　真、野出孝一
- Total Pages
  6
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-26670543
[Book] THE LUNG perspectives2015
- Author(s)
  明石　真
- Total Pages
  8
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-26670543
[Book] Diabetes Journal2015
- Author(s)
  明石　真
- Total Pages
  9
- Publisher
  協和企画
- Data Source
  KAKENHI-PROJECT-26670543
[Book] いま小児科医に必要な実践臨床小児睡眠医学2015
- Author(s)
  明石　真
- Total Pages
  9
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-26670543
[Book] Heart View 概日時計の振動原理2012
- Author(s)
  明石真、野出孝一
- Total Pages
  8
- Publisher
  メジカルビュー社
- Data Source
  KAKENHI-PROJECT-24591060
[Journal Article] Cell Collection Device from Mucosal Tissue Using Cavitation Caused by Ultrasound Irradiation2022
- Author(s)
  Yang Ye、Uechi Tatsuya、Tsuruoka Noriko、Akashi Makoto、Haga Yoichi
- Journal Title
  
  Journal of Japan Society of Computer Aided Surgery
  
  Volume: 24 Issue: 4 Pages: 217-225
- DOI
  10.5759/jscas.24.217
- ISSN
  1344-9486, 1884-5770
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H04545
[Journal Article] The role of cell-autonomous circadian oscillation of Cry transcription in circadian rhythm generation2022
- Author(s)
  Matsumura Ritsuko、Yoshimi Kazuto、Sawai Yuka、Yasumune Nanami、Kajihara Kohhei、Maejima Tatsuya、Koide Tsuyoshi、Node Koichi、Akashi Makoto
- Journal Title
  
  Cell Reports
  
  Volume: 39 Issue: 3 Pages: 110703-110703
- DOI
  10.1016/j.celrep.2022.110703
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06769, KAKENHI-PROJECT-22K19238, KAKENHI-PROJECT-20K15843, KAKENHI-PROJECT-19KK0401, KAKENHI-PROJECT-19KK0177
[Journal Article] Device to Collect Skin Cells Using Ultrasound Irradiation and Aspiration2022
- Author(s)
  Ye Yang、Uechi Tatsuya、Tsuruoka Noriko、Akashi Makoto、Haga Yoichi
- Journal Title
  
  Sensors and Materials
  
  Volume: 34 Issue: 9 Pages: 3383
- DOI
  10.18494/SAM3983
- ISSN
  0914-4935, 2435-0869
- Year and Date
  2022-09-06
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H04545
[Journal Article] Potential role of the pancreatic hormone insulin in resetting human peripheral clocks2018
- Author(s)
  Kajimoto J, Matsumura R, Node K, Akashi M.
- Journal Title
  
  Genes to Cells
  
  Volume: 23 Issue: 5 Pages: 393-399
- DOI
  10.1111/gtc.12582
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K14776, KAKENHI-PROJECT-17K15600
[Journal Article] A simple method using ex vivo culture of hair follicle tissue to investigate intrinsic circadian characteristics in humans2017
- Author(s)
  Yamaguchi Ai、Matsumura Ritsuko、Matsuzaki Takashi、Nakamura Wataru、Node Koichi、Akashi Makoto
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 6824-6824
- DOI
  10.1038/s41598-017-07268-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15562
[Journal Article] Effect of different light-dark schedules on estrous cycle in mice, and implications for mitigating the adverse impact of night work2017
- Author(s)
  Yoshinaka Kiichi、Yamaguchi Ai、Matsumura Ritsuko、Node Koichi、Tokuda Isao、Akashi Makoto
- Journal Title
  
  Genes Cells
  
  Volume: 22 Issue: 10 Pages: 876-884
- DOI
  10.1111/gtc.12522
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K00343, KAKENHI-PROJECT-16K14776, KAKENHI-PROJECT-26286086
[Journal Article] Estimation methods for human circadian phase using peripheral tissues2016
- Author(s)
  Matsumura. R., Node. K., Akashi. M.
- Journal Title
  
  Hypertension Research
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670543
[Journal Article] Estimation methods for human circadian phase by use of peripheral tissues2016
- Author(s)
  Matsumura. R., Node. K., and Akashi. M.
- Journal Title
  
  Hypertension Research
  
  Volume: 39 Issue: 9 Pages: 623-627
- DOI
  10.1038/hr.2016.68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15562
[Journal Article] The mammalian circadian clock protein period counteracts cryptochrome in phosphorylation dynamics of circadian locomotor output cycles kaput (CLOCK).2014
- Author(s)
  Matsumura R, Tsuchiya Y, Tokuda I, Matsuo T, Sato M, Node K, Nishida E, Akashi M.
- Journal Title
  
  J Biol Chem.
  
  Volume: 289(46) Issue: 46 Pages: 32064-72
- DOI
  10.1074/jbc.m114.578278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591060
[Journal Article] Compensation for intracellular environment in expression levels of mammalian circadian clock genes.2014
- Author(s)
  Matsumura R, Okamoto A, Node K, Akashi M.
- Journal Title
  
  Sci Rep.
  
  Volume: 4 Issue: 1 Pages: 4032-4032
- DOI
  10.1038/srep04032
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591060
[Journal Article] The role of the endocrine system in feeding-induced tissue-specific circadian entrainment.2014
- Author(s)
  Sato M, Murakami M, Node K, Matsumura R, Akashi M.
- Journal Title
  
  Cell Rep.
  
  Volume: 8(2) Issue: 2 Pages: 393-401
- DOI
  10.1016/j.celrep.2014.06.015
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591060
[Journal Article] An out-of-lab trial: a case example for the effect of intensive exercise on rhythms of human clock gene expression.2013
- Author(s)
  Okamoto A, Yamamoto T, Matsumura R, Node K, Akashi M.
- Journal Title
  
  J Circadian Rhythms.
  
  Volume: 11(1) Issue: 0 Pages: 10-10
- DOI
  10.1186/1740-3391-11-10
- NAID
  120005367883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591060
[Journal Article] A molecular clock regulates angiopoietin-like protein 2 expression.2013
- Author(s)
  Kadomatsu T et al
- Journal Title
  
  PloS One
  
  Volume: 8 Issue: 2 Pages: e57921-e57921
- DOI
  10.1371/journal.pone.0057921
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24241018, KAKENHI-PROJECT-24591060, KAKENHI-PROJECT-25461114
[Journal Article] Nuclear receptor-mediated cell-autonomous oscillatory expression of the circadian transcription factor, neuronal PAS domain protein 2.2013
- Author(s)
  Matsumura R et al.
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Issue: 51 Pages: 36548-53
- DOI
  10.1074/jbc.m113.517235
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23111005, KAKENHI-PROJECT-24591060, KAKENHI-PROJECT-25242077
[Journal Article] MAP kinase is a functional component of the autonomous circadian system in the suprachiasmatic nucleus2008
- Author(s)
  Hayasaka N, Akashi M, Yamazaki S, Node M
- Journal Title
  
  J Neurosci 28(18)
  
  Pages: 4619-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590235
[Presentation] インターネットによる概日リズムの多地点同時計測装置の開発2017
- Author(s)
  岩政翔大、明石真、松野浩嗣
- Organizer
  日本時間学会第9回大会
- Data Source
  KAKENHI-PROJECT-16K14776
[Presentation] 概日時計を研究する意義2016
- Author(s)
  明石　真
- Organizer
  第３８回日本臨床栄養学会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2016-10-07
- Invited
- Data Source
  KAKENHI-PROJECT-16K15562
[Presentation] なぜ体内時計は大切なのか2015
- Author(s)
  明石　真
- Organizer
  電気・情報関連学会中国支部連合大会
- Place of Presentation
  山口大学（山口県宇部市）
- Year and Date
  2015-10-17
- Invited
- Data Source
  KAKENHI-PROJECT-26670543
[Presentation] 食と体内時計2015
- Author(s)
  明石　真
- Organizer
  日本糖尿病学会
- Place of Presentation
  下関市民会館（山口県下関市）
- Year and Date
  2015-05-21
- Invited
- Data Source
  KAKENHI-PROJECT-26670543

1. NODE Koichi (80359950)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
2. NAKAJIMA Yoshihiro (10291080)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. INOUE Teruo (20168454)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. HIRASE Tetsuaki (60363446)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. HAYASAKA Naoto (80368290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. KATSUYA Tomohiro (30311757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SAKATA Yasuhiko (90379206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. IMAI Yutaka (40133946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OYAMA Jun-ichi (30359939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SATO Yasunori (90536723)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. TOKUDA Isao (00261389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. HIRANO Hitoshi (70228807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YOSHIDA Hiroki (40260715)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Matsuno Hiroshi (10181744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. ENDO TAKUYUKI (40573225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Haga Yoichi (00282096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 渡辺和人 (80146167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 佐古田三郎 (00178625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 鶴岡典子 (70757632)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TATSUMOTO Muneto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. YAMAGUCHI Ai

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. MATSUMURA Ritsuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
23. SUMINO Junko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Akashi Makoto 明石 真

AKASHI Makoto 明石 真

明石 真 アカシ マコト

Research Projects

Research Products

Co-Researchers

白色脂肪組織による哺乳類冬眠制御の分子メカニズムPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

概日時計の転写フィードバック中枢振動体を補償するメカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of technologies for precise manipulation of cell and tissue in the body

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of cell-autonomous circadian oscillation of clock gene transcription in circadian rhythm generationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Global scale measurement and analysis of animal behavior with environmental factors through the internet

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional assessment of the circadian clock of patients with neurodegenerative disorders based on clock gene expressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a detection method for circadian rhythm sleep disorders based on clock gene expressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Novel Therapy with Bright Light System in Parkinson's Disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of clock gene in cardiovascular disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

概日時計構成因子Periodの機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses of molecular mechanisms underlying circadian rhythm generation and synchronization by rapid and efficient gene transduction in vivo

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of EET in cardiovascular disease.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of WSX-1 in atherosclerosis

Principal Investigator

Akashi Makoto 明石真

AKASHI Makoto 明石真

明石真アカシマコト