SUGITA Hiroki 杉田裕樹

Researcher Number	30398218
Other IDs
Affiliation (based on the past Project Information) *help	2008 – 2013: Kumamoto University, 医学部附属病院, 非常勤診療医師 2006 – 2007: 熊本大学, 医学部附属病院, 講師
Review Section/Research Field	Principal Investigator Digestive surgery
Keywords	Principal Investigator Akt / 膵癌 / IRS-1 / 一酸化窒素(NO) / insulin / MEK / IGF-I / ユビキチン化 / 癌 / GSK(glvcogen svnthase kinase)-3 … More / pancreatic cancer / ubiquitin / IGF(insulin like growth factor)-1 / TRS(insulin receptor substrate)-1 / nitric oxide / insulin like growth factor-1 / 膵癌細胞 / insulin receptor substrate-1 / GSK3 / ユビキチン / IGF / NO(一酸化窒素) / PI3-K / 増殖シグナル / MAPK / EGFR / NO / PI3-K/ Akt / Yeast two hybrid assay / PI3-K/Akt / IGF-iR / RTK / 一酸化窒素 / PKB / EGF / Akt/PKB / IGFシグナル Less

Proteomic analysis for RTK regulation by nitric oxide and its application to cancer therapyPrincipal Investigator
- Principal Investigator
  
  SUGITA Hiroki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kumamoto University
Proteomic analysis of the regulation of proteins by NO-induced posttranslational modification and anti-cancer therapyPrincipal Investigator
- Principal Investigator
  
  SUGITA Hiroki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kumamoto University
The analysis of molecular mechanism for IRS-1 ubiquitination by nitric oxidePrincipal Investigator
- Principal Investigator
  
  SUGITA Hiroki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kumamoto University

All 2014 2013 2012 2011 2010 2009 2008 2007 2006

All Journal Article Presentation Book

[Book] Pancreatic cancer, Molecular mechanism and targets2012
- Author(s)
  Hiroki Sugita
- Publisher
  Intech
- Data Source
  KAKENHI-PROJECT-23592016
[Book] Pancreatic Cancer, chapter : Nitric oxide regulates growth factor signaling in pancreatic cancer2012
- Author(s)
  Sugita H,Furuhashi S, Baba H.
- Publisher
  Intech
- Data Source
  KAKENHI-PROJECT-23592016
[Book] Pancreatic Cancer, chapter: Nitric oxide regulates growth factor signaling in pancreatic cancer2012
- Author(s)
  Sugita H, Furuhashi S, Baba H
- Total Pages
  14
- Publisher
  Intech ISBN 978-953-307-815-1
- Data Source
  KAKENHI-PROJECT-23592016
[Journal Article] Statins inhibit tumor progression via an enhancer of zeste homolog 2-mediated epigenetic alteration in colorectal cancer.2014
- Author(s)
  S. Ishikawa, H. Hayashi, K. Kinoshita, M. Abe, H. Kuroki, R. Tokunaga, S. Tomiyasu, H. Tanaka, H. Sugita, T. Arita, Y. Yagi, M. Watanabe, M. Hirotaand　H. Baba
- Journal Title
  
  Internationa Journal of Cancer
  
  Volume: Epub ahead of print Issue: 11 Pages: 2528-36
- DOI
  10.1002/ijc.28672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592016, KAKENHI-PROJECT-24591911, KAKENHI-PROJECT-25462062, KAKENHI-PROJECT-25670588
[Journal Article] NO donor and MEK inhibitor synergistically inhibit proliferation and invasion of cancer cells2012
- Author(s)
  Furuhashi S, Sugita H, Takamori H, Horino K, Nakahara O, Okabe H, Miyake K, Tanaka H, Beppu T, Baba H
- Journal Title
  
  Int J Oncol
  
  Volume: 40(3) Pages: 807-15
- DOI
  10.3892/ijo.2011.1243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591898, KAKENHI-PROJECT-23592015, KAKENHI-PROJECT-23592016
[Journal Article] Inducible nitric oxide synthase deficiency ameliorates skeletal muscle insulin resistance but does not alter unexpected lower blood glucose levels after burn injury in C57BL/6 mice.2012
- Author(s)
  Michiko Sugita, Hiroki Sugita
- Journal Title
  
  Metabolism
  
  Volume: 61 Issue: 1 Pages: 127-136
- DOI
  10.1016/j.metabol.2011.06.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592016
[Journal Article] The duration of SIRS before organ failure is a significant prognostic factor of sepsis2012
- Author(s)
  Sugita H, Kinoshita Y, Baba H.
- Journal Title
  
  Int J Emerg Med.
  
  Volume: 5(1) Issue: 1 Pages: 44-44
- DOI
  10.1186/1865-1380-5-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592016
[Journal Article] Distal pancreatectomy using a no-touch isolation technique2012
- Author(s)
  Masahiko Hirota, Hiroki Sugita
- Journal Title
  
  Scand J Surg
  
  Volume: 101 Issue: 3 Pages: 156-159
- DOI
  10.1177/145749691210100303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592016, KAKENHI-PROJECT-24890172
[Journal Article] Distal pancreatectomy using a no-touch isolation technique2012
- Author(s)
  Hirota M, Hashimoto D, Ishiko T, Satoh N, Takamori H, Chikamoto A, Tanaka H, Sugita H, Sand J, Nordback I, Baba H.
- Journal Title
  
  Scand J Surg
  
  Volume: 101(3) Pages: 156-9
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/22968237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592016
[Journal Article] Pancreatoduodenectomy using a no-touch isolation technique.2010
- Author(s)
  Hirota M, Kanemitsu K, Takamori H, Chikamoto A, Tanaka H, Sugita H, Sand J, Nordback I, Baba H.
- Journal Title
  
  Am J Surg. 199(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591633
[Journal Article] Serum HGF and TGF-betal levels after right portal vein embolization2010
- Author(s)
  Hayashi H, Beppu T, Sugita H, Masuda T, Okabe H, Takamori H, Baba H.
- Journal Title
  
  Hepatol Res. 40(3)
  
  Pages: 311-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591633
[Journal Article] Pancreatoduodenectomy using a no-touch isolation technique.2010
- Author(s)
  Hirota M, Kanemitsu K, Takamori H, Chikamoto A, Tanaka H, Sugita H, Sand J, Nordback I, Baba H.
- Journal Title
  
  Am J Surg.
  
  Volume: 199 Pages: 65-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591633
[Journal Article] Nitric oxide inhibits proliferation and invasion activity of pancreatic cancer cells through degradation of insulin receptor substrate-1 protein2010
- Author(s)
  Sugita H, Kneki M, Furuhashi S, Takamori H, Horino K, Baba H
- Journal Title
  
  Mol Cancer Res.
  
  Volume: 8 Pages: 1152-1163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591633
[Journal Article] Serum HGF and TGF-beta1 levels after right portal vein embolization2010
- Author(s)
  Hayashi H, Beppu T, Sugita H, Masuda T, Okabe H, Takamori H, Baba H
- Journal Title
  
  Hepatol Res.
  
  Volume: 40 Pages: 311-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591633
[Journal Article] Nitric oxide inhibits proliferation and invasion activity of pancreatic cancer cells through degradation of insulin receptor substrate-1 protein2010
- Author(s)
  Sugita H, Masao K aneki, Masahiko Hirota, Satoshi Furuhashi, Hiroshi Takamori, Hideo Baba-
- Journal Title
  
  Mol Cancer Res. 8
  
  Pages: 1152-1163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591633
[Journal Article] Increase in the serum bile acid level predicts the effective hypertrophy of the nonembolized hepatic lobe after right portal vein embolization.2009
- Author(s)
  Hayashi H, Beppu T,Sugita H, Horino K, Komori H, Masuda T, Okabe H, Takamori H, Baba H.
- Journal Title
  
  World J Surg 33(9)
  
  Pages: 1933-1940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591633
[Journal Article] radical retropubic prostatectomy and abdominoperineal excision of the rectum for locally invasive rectal cancer as a less invasive surgery : report of a case.2008
- Author(s)
  Sugita, H., Egami, H., Yokoyama, Y., Suyama, K, Ogawa
- Journal Title
  
  Int. J. Surg. 92(5)
  
  Pages: 249-251
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591517
[Journal Article] Combined radical retropubic prostatectomy and abdominoperineal excision of the rectum for locally invasive rectal cancer as a less invasive surgery:report of a case2008
- Author(s)
  Sugita H.
- Journal Title
  
  Int.J.Surg. 92
  
  Pages: 249-251
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591517
[Journal Article] Pancreatoduodenectomy using a no-touch isolation technique.2008
- Author(s)
  Hirota M, Kanemitsu K, Takamori H, Chikamoto A, Tanaka H, Sugita H, Sand J, Nordback I, Baba H.
- Journal Title
  
  Am J Surg.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591633
[Journal Article] Combined radical retropubic prostatectomy and abdominoperineal excision of the rectum for locally invasive rectal cancer as a less invasive surgery: report of a case.2008
- Author(s)
  Sugita H
- Journal Title
  
  Int. J. Surg. 92
  
  Pages: 249-251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591517
[Journal Article] Farnesyltransferase inhibitor,manumycin a,prevents atherosclerosis development and reduces oxidative stress in apolipoprotein E-deficient mice2007
- Author(s)
  Sugita M
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 27
  
  Pages: 1390-13905
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591517
[Journal Article] Farnesyltransferase Inhibitor, Manumycin A, Prevents Atherosclerosis Development and Reduces Oxidative Stress in Apolipoprotein E-Deficient Mice.2007
- Author(s)
  Sugita M, Sugita H, Kaneki M
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 27
  
  Pages: 1-7
- Data Source
  KAKENHI-PROJECT-18591517
[Journal Article] 進行胆道癌におけるIrinotecan+low-dose CDDP(I/low-P) 療法2007
- Author(s)
  杉田裕樹
- Journal Title
  
  肝胆膵 55
  
  Pages: 1017-1023
- Data Source
  KAKENHI-PROJECT-18591517
[Journal Article] Farnesyltransferase inhibitor, manumycin a, prevents atherosclerosis development and reduces oxidative stress in apolipoprotein E-deficient mice2007
- Author(s)
  Sugita, M, Sugita, H, Kaneki, M
- Journal Title
  
  Arterioscler Thromb Vase Biol 27(6)
  
  Pages: 1390-5
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591517
[Journal Article] Farnesyltransferase inhibitor,manumycin a,prevents atherosclerosis development and reduces oxidative stress in apolipoprotein E-deficient mice.2007
- Author(s)
  Sugita M
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 27
  
  Pages: 1390-13905
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591517
[Journal Article] 進行胆道癌におけるIrinotecan+low-dose CDDP(I/low-P)療法2007
- Author(s)
  杉田裕樹
- Journal Title
  
  肝胆膵 55
  
  Pages: 1017-1023
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591517
[Journal Article] Combined Chemotherapy of Irinotecan and Low-dose Cisplatin(I/low-P) against Metastatic Biliary Tract Cancer : Report of Consecutive Three Cases2006
- Author(s)
  Sugita, H., Hirota, M., Ichihara, A., Furuhashi, S., Kihara, S., Shimada, S.
- Journal Title
  
  J Hepatobiliary Pancreat Surg 13(5)
  
  Pages: 463-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591517
[Journal Article] Combined Chemotherapy of Irinotecan and Low-dose Cisplatin(I/low-P)against Metastatic Biliary Tract Cancer2006
- Author(s)
  Sugita H.
- Journal Title
  
  J Hepatobiliary Pancreat Surg 13
  
  Pages: 463-467
- NAID
  10018765256
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591517
[Journal Article] Adipocyte apoptosis after burn injury is associated with altered fat metabolism.2006
- Author(s)
  Yasuhara S, Kaneki, Sugita H, Sugita M, Asai A, Sahani N, Chon JY, Tompkins RG, Martyn JA
- Journal Title
  
  J Burn Care Res. 27
  
  Pages: 367-376
- Data Source
  KAKENHI-PROJECT-18591517
[Journal Article] Combined chemotherapy of irinotecan and low-dose cisplatin (I/low-P) against metastatic biliary tract cancer.2006
- Author(s)
  Sugita H, Hirota M, Ichihara A, Furuhashi S, Kihara S, Shimada S
- Journal Title
  
  J Hepatobiliary Pancreat Surg. 13
  
  Pages: 463-467
- NAID
  10018765256
- Data Source
  KAKENHI-PROJECT-18591517
[Journal Article] Chon JY, Tompkins RC, and Martyn. JAA dipocyte apoptosis after burn injury is associated with altered fat metabolism2006
- Author(s)
  Yasuhara, S, Kaneki, M, Sugita, H, Sugita, M, Asai, A, Sahani, N
- Journal Title
  
  J Burn Care Res 27(3)
  
  Pages: 367-76
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591517
[Presentation] 外科的手術が施行された残胃癌の予後についての検討2014
- Author(s)
  杉田裕樹
- Organizer
  第114回日本外科学会
- Place of Presentation
  国立京都国際会館(発表確定)
- Year and Date
  2014-04-03
- Data Source
  KAKENHI-PROJECT-23592016
[Presentation] 外科的手術が施行された残胃癌の予後についての検討2014
- Author(s)
  杉田　裕樹
- Organizer
  第114回日本外科学会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23592016
[Presentation] 絞扼性イレウスに対する腹腔鏡下イレウス解除術についての経験2013
- Author(s)
  杉田裕樹
- Organizer
  第26回日本内視鏡外科学会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2013-11-28
- Data Source
  KAKENHI-PROJECT-23592016
[Presentation] The role of nitric oxide in growth factor signaling of cancer cells2011
- Author(s)
  Sugita H, Furuhashi S, Baba H.
- Organizer
  2nd World DNA and Genome Day
- Place of Presentation
  Dalian, China
- Year and Date
  2011-04-28
- Data Source
  KAKENHI-PROJECT-23592016
[Presentation] The role of nitric oxide in growth factor signaling of cancer cells.2011
- Author(s)
  杉田裕樹, 古橋聡, 馬場秀夫
- Organizer
  World DNA and Genome Day
- Place of Presentation
  Dalian EXPO Center, Dalian, China
- Year and Date
  2011-04-28
- Data Source
  KAKENHI-PROJECT-20591633
[Presentation] 膵癌細胞株におけるNO donorおよびMEK inhibitorの併用による抗腫瘍効果の検討2010
- Author(s)
  古橋聡、杉田裕樹、阿部真也、中原修、井田智、尾崎宣之、田中洋、堀野敬、高森啓史、別府透、馬場秀夫
- Organizer
  日本外科学会総会
- Place of Presentation
  名古屋国際会議場、名古屋
- Year and Date
  2010-04-09
- Data Source
  KAKENHI-PROJECT-20591633
[Presentation] 膵癌細胞におけるNO(一酸化窒素)によるPI3-K/Akt pathway制御機構の検討2010
- Author(s)
  杉田裕樹、古橋聡、高森啓史、馬場秀夫
- Organizer
  日本外科学会総会
- Place of Presentation
  名古屋
- Year and Date
  2010-04-09
- Data Source
  KAKENHI-PROJECT-20591633
[Presentation] 膵癌細胞株におけるNO donorおよびMEK inhibitorの併用による抗腫瘍効果の検討2010
- Author(s)
  古橋聡、杉田裕樹、阿部真也、中原修、井田智、尾崎宣之、田中洋、堀野敬、高森啓史、別府透、馬場秀夫
- Organizer
  日本外科学会総会
- Place of Presentation
  名古屋
- Year and Date
  2010-04-09
- Data Source
  KAKENHI-PROJECT-20591633
[Presentation] 膵癌細胞におけるNO(一酸化窒素)によるPI3-K/Akt pathway制御機構の検討2010
- Author(s)
  杉田裕樹、古橋聡、高森啓史、馬場秀夫
- Organizer
  日本外科学会総会
- Place of Presentation
  名古屋国際会議場、名古屋
- Year and Date
  2010-04-09
- Data Source
  KAKENHI-PROJECT-20591633
[Presentation] 膵癌細胞において発現するiNOSによるinsulin/IGFシグナルの制御2008
- Author(s)
  杉田裕樹、廣田昌彦、市原敦史、馬場秀夫
- Organizer
  日本外科学会総会
- Place of Presentation
  長崎ブリックホール、長崎
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-20591633
[Presentation] NOによるIRS-1蛋白分解と膵癌細胞の増殖抑制2006
- Author(s)
  杉田裕樹
- Organizer
  日本消化器外科
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591517
[Presentation] 膵癌細胞の増殖シグナルにおけるNOの役割2006
- Author(s)
  杉田裕樹
- Organizer
  日本外科学会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591517

1. TAKAMORI Hiroshi (90363514)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
2. HIROTA Masahiko (80284769)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KAMOHARA Hidenobu (90398222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. BABA Hideo (20240905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HORINO Kei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. BEPPU Toru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 廣田昌彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results

SUGITA Hiroki 杉田 裕樹

Research Projects

Research Products

Co-Researchers

Proteomic analysis for RTK regulation by nitric oxide and its application to cancer therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Proteomic analysis of the regulation of proteins by NO-induced posttranslational modification and anti-cancer therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of molecular mechanism for IRS-1 ubiquitination by nitric oxidePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Pancreatic cancer, Molecular mechanism and targets2012

Author(s)

Publisher

Data Source

[Book] Pancreatic Cancer, chapter : Nitric oxide regulates growth factor signaling in pancreatic cancer2012

Author(s)

Publisher

Data Source

[Book] Pancreatic Cancer, chapter: Nitric oxide regulates growth factor signaling in pancreatic cancer2012

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Statins inhibit tumor progression via an enhancer of zeste homolog 2-mediated epigenetic alteration in colorectal cancer.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NO donor and MEK inhibitor synergistically inhibit proliferation and invasion of cancer cells2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inducible nitric oxide synthase deficiency ameliorates skeletal muscle insulin resistance but does not alter unexpected lower blood glucose levels after burn injury in C57BL/6 mice.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The duration of SIRS before organ failure is a significant prognostic factor of sepsis2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distal pancreatectomy using a no-touch isolation technique2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distal pancreatectomy using a no-touch isolation technique2012

Author(s)

Journal Title

URL

Data Source

[Journal Article] Pancreatoduodenectomy using a no-touch isolation technique.2010

Author(s)

Journal Title

Data Source

[Journal Article] Serum HGF and TGF-betal levels after right portal vein embolization2010

Author(s)

Journal Title

Data Source

[Journal Article] Pancreatoduodenectomy using a no-touch isolation technique.2010

Author(s)

Journal Title

Data Source

[Journal Article] Nitric oxide inhibits proliferation and invasion activity of pancreatic cancer cells through degradation of insulin receptor substrate-1 protein2010

Author(s)

Journal Title

SUGITA Hiroki 杉田裕樹