UNO Tsukasa 宇野司

Researcher Number	30400138
Other IDs
Affiliation (based on the past Project Information) *help	2008 – 2010: University of the Ryukyus, 医学部附属病院, 教授
Review Section/Research Field	Principal Investigator Medical pharmacy
Keywords	Principal Investigator オメプラゾール光学異性体 / オメプラゾール / HPLC / AUC / CYP2C19 / 代謝学 / 薬物動態

Research Projects
(1 results)
Research Products
(16 results)

The prediction of Helicobacter Pylori eradication using CYP2C19 activity determined by limited plasma concentration of omeprazole enantiomersPrincipal Investigator
- Principal Investigator
  
  UNO Tsukasa
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of the Ryukyus

All 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] Comparison of drug sensitivity and genotypes of clinically isolated strains of levofloxacin-resistant Streptococcus pneumoniae obtained from Okinawa Island, the Japanese main island and Hong Kong.2011
- Author(s)
  Sunagawa S, Fujita J, Higa F, Tateyama M, Haranaga S, Nakasone I, Yamane N, Uno T.
- Journal Title
  
  J Antibiot (Tokyo) in press
- NAID
  10030639796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590150
[Journal Article] Effects of the CYP2D6*10 allele on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole, in Japanese patients with schizophrenia.2011
- Author(s)
  Suzuki T, Mihara K, Nakamura A, Nagai G, Kagawa S, Nemoto K, Ohta I, Arakaki H, Uno T, Kondo T.
- Journal Title
  
  Ther Drug Monit 33
  
  Pages: 21-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590150
[Journal Article] Standard warfarin dose in a patient with the CYP2C9*3/*3 genotype leads to hematuria.2010
- Author(s)
  Goto T, Miura M, Murata A, Terata K, Uno T, Yamamoto K, Abe Y.
- Journal Title
  
  Clin Chim Acta 6
  
  Pages: 1375-1377
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590150
[Journal Article] Influence of drug-transporter polymorphisms on the pharmacokinetics of fexofenadine enantiomers.2010
- Author(s)
  Akamine Y, Miura M, Sunagawa S, Kagaya H, Yasui-Furukori N, Uno T.
- Journal Title
  
  Xenobiotica 40
  
  Pages: 782-729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590150
[Journal Article] Clinical pharmacokinetics of fexofenadine enantiomers.2010
- Author(s)
  Miura M, Uno T.
- Journal Title
  
  Expert Opin Drug Metab Toxicol 6
  
  Pages: 69-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590150
[Journal Article] A sensitive column-switching HPLC method for aripiprazole and dehydroaripiprazole and its application to human pharmacokinetic studies.2010
- Author(s)
  Akamine Y, Yasui-Furukori N, Kojima M, Inoue Y, Uno T.
- Journal Title
  
  J Sep Sci 33
  
  Pages: 3292-3298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590150
[Journal Article] Effects of the P-glycoprotein Inducer Carbamazepine on Fexofenadine Pharmacokinetics.2009
- Author(s)
  Yamada S, Yasui-Furukori N, Akamine Y, Kaneko S, Uno T.
- Journal Title
  
  Ther Drug Monit 31
  
  Pages: 764-768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590150
[Journal Article] Enantioselective disposition of fexofenadine with the P-glycoprotein inhibitor verapamil.2009
- Author(s)
  Sakugawa T, Miura M, Hokama N, Suzuki T, Tateishi T, Uno T.
- Journal Title
  
  Br J Clin Pharmacol 67
  
  Pages: 535-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590150
[Journal Article] Limited frequency of the CYP2C19^*17 allele and its minor role in a Japanese population.2008
- Author(s)
  Sugimoto K, Uno T, Yamazaki H, Tateishi T
- Journal Title
  
  Br J Clin Pharmacol 65
  
  Pages: 437-439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590150
[Journal Article] The different effects of itraconazole on the pharmacokinetics of fexofe nadine enantiomers.2008
- Author(s)
  Tateishi T, Miura M, Suzuki T, Uno T
- Journal Title
  
  Br J Clin Pharmacol 65
  
  Pages: 693-700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590150
[Journal Article] The role of CYP2C19 in the R-warfarin pharmacokinetics and its inter action by omeprazole.2008
- Author(s)
  Uno T, Sugimoto T, Sugawara K, Tateishi T
- Journal Title
  
  Ther Drug Monit 30
  
  Pages: 276-281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590150
[Journal Article] The effect of CYP2C19 genotypes on the pharmacokinetics of warfarin enantiomers.2008
- Author(s)
  Uno T, Sugimoto T, Sugawara K, Tateishi T
- Journal Title
  
  J Clin Pharm Ther 33
  
  Pages: 67-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590150
[Journal Article] The different effects of itraconazole on the pharmacokinetics of fexofenadine enantiomers.2008
- Author(s)
  Tateishi T, Miura M, Suzuki T, Uno T
- Journal Title
  
  Br J Clin Pharmacol 65
  
  Pages: 693-700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590150
[Journal Article] Estimation of the area under the concentration-time curve of racemic lansoprazole by using limited plasma concentration of lansoprazole enantiomers.2008
- Author(s)
  Niioka T, Miura M, Uno I, Yasui-Furukori N, Hayakari M, Tateishi T, Suzuki T
- Journal Title
  
  Eur J Clin Pharmacol 64
  
  Pages: 503-509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590150
[Journal Article] Effects of the CYP3A5 genotype on omeprazole sulfoxidation in CYP2C19PMS.2008
- Author(s)
  Sugimoto K, Uno T, Tateishi T
- Journal Title
  
  Eur J Clin Pharmacol 64
  
  Pages: 583-587
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590150
[Presentation] ラベプラソールとその主代謝物の高感度定量によるCYP2C19遺伝子型に関連したCYP3AまたはP-gp阻害剤とのin vivo併用効果2008
- Author(s)
  外間惟夫, 清水美貴子, 立石智則, 宇野司
- Organizer
  日本TDM学会
- Place of Presentation
  東京都江戸川区
- Data Source
  KAKENHI-PROJECT-20590150

UNO Tsukasa 宇野 司

Research Projects

Research Products

The prediction of Helicobacter Pylori eradication using CYP2C19 activity determined by limited plasma concentration of omeprazole enantiomersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Comparison of drug sensitivity and genotypes of clinically isolated strains of levofloxacin-resistant Streptococcus pneumoniae obtained from Okinawa Island, the Japanese main island and Hong Kong.2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Effects of the CYP2D6*10 allele on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole, in Japanese patients with schizophrenia.2011

Author(s)

Journal Title

Data Source

[Journal Article] Standard warfarin dose in a patient with the CYP2C9*3/*3 genotype leads to hematuria.2010

Author(s)

Journal Title

Data Source

[Journal Article] Influence of drug-transporter polymorphisms on the pharmacokinetics of fexofenadine enantiomers.2010

Author(s)

Journal Title

Data Source

[Journal Article] Clinical pharmacokinetics of fexofenadine enantiomers.2010

Author(s)

Journal Title

Data Source

[Journal Article] A sensitive column-switching HPLC method for aripiprazole and dehydroaripiprazole and its application to human pharmacokinetic studies.2010

Author(s)

Journal Title

Data Source

[Journal Article] Effects of the P-glycoprotein Inducer Carbamazepine on Fexofenadine Pharmacokinetics.2009

Author(s)

Journal Title

Data Source

[Journal Article] Enantioselective disposition of fexofenadine with the P-glycoprotein inhibitor verapamil.2009

Author(s)

Journal Title

Data Source

[Journal Article] Limited frequency of the CYP2C19^*17 allele and its minor role in a Japanese population.2008

Author(s)

Journal Title

Data Source

[Journal Article] The different effects of itraconazole on the pharmacokinetics of fexofe nadine enantiomers.2008

Author(s)

Journal Title

Data Source

[Journal Article] The role of CYP2C19 in the R-warfarin pharmacokinetics and its inter action by omeprazole.2008

Author(s)

Journal Title

Data Source

[Journal Article] The effect of CYP2C19 genotypes on the pharmacokinetics of warfarin enantiomers.2008

Author(s)

Journal Title

Data Source

[Journal Article] The different effects of itraconazole on the pharmacokinetics of fexofenadine enantiomers.2008

Author(s)

Journal Title

Data Source

[Journal Article] Estimation of the area under the concentration-time curve of racemic lansoprazole by using limited plasma concentration of lansoprazole enantiomers.2008

Author(s)

Journal Title

Data Source

[Journal Article] Effects of the CYP3A5 genotype on omeprazole sulfoxidation in CYP2C19PMS.2008

Author(s)

Journal Title

Data Source

[Presentation] ラベプラソールとその主代謝物の高感度定量によるCYP2C19遺伝子型に関連したCYP3AまたはP-gp阻害剤とのin vivo併用効果2008

Author(s)

Organizer

Place of Presentation

Data Source

UNO Tsukasa 宇野司

[Journal Article] Standard warfarin dose in a patient with the CYP2C93/3 genotype leads to hematuria.2010