Nagano Osamu 永野修

… Alternative Names

NAGANO Osamu 永野修

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Researcher Number	30404346
Other IDs
Affiliation (Current)	2025: 藤田医科大学, 腫瘍医学研究センター, 教授
Affiliation (based on the past Project Information) *help	2025: 藤田医科大学, 腫瘍医学研究センター, 教授 2023: 藤田医科大学, がん医療研究センター, 教授 2023: 藤田医科大学, 腫瘍医学研究センター, 教授 2021 – 2022: 慶應義塾大学, 医学部(信濃町), 准教授 2018 – 2019: 慶應義塾大学, 医学部(信濃町), 准教授 … More 2017: 慶應義塾大学, 医学部(信濃町), 講師 2012 – 2014: 慶應義塾大学, 医学部, 講師 2007 – 2011: Keio University, 医学部, 助教 2006: 熊本大学, 生命資源研究・支援センター, 研究員 Less
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Medium-sized Section 50:Oncology and related fields / Basic Section 50010:Tumor biology-related / Tumor biology / Cell biology Except Principal Investigator Basic Section 57060:Surgical dentistry-related
Keywords	Principal Investigator 小細胞肺癌 / フェロトーシス / 癌 / p62 / xCT / 癌幹細胞 / 細胞・組織 / 遺伝子 / HAS / CD44 … More / 細胞死 / 肺癌 / CASP8 / SMARCA4 / がん幹細胞 / 小細胞肺がん / 肺がん / オートファジー / 抗がん剤耐性 / p62/SQSTM1 / 酸化ストレス / 活性酸素種 / グルタチオン / 代謝 / 糖代謝 / EpCAM / 遺伝性 / 癌細胞浸潤 / EMT / 網膜色素上皮 / ERM / ADAM17 / ヒアルロン酸 / 脳腫瘍 … More Except Principal Investigator 免疫逃避 / スプライシングアイソフォーム / CD47 / エクソソーム / 口腔癌 Less

口腔癌のエクソソームとCD47スプライシングアイソフォームによる免疫逃避の解明
- Principal Investigator
  
  莇生田整治
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Keio University
Elucidation of mechanisms of xCT-mediated cancer therapy resistance accompanied with metabolic reprograming and cancer stem cell propertyPrincipal Investigator
- Principal Investigator
  
  Nagano Osamu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Fujita Health University
  Keio University
Development of the therapy targeted to the vulnerability of SMARCA4-mutant lung cancer cells to ferroptosisPrincipal Investigator
- Principal Investigator
  
  Nagano Osamu
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Keio University
Elucidation of the mechanism of the induction of ferroptosis by xCT inhibitor and its antitumor effect in small cell lung cancerPrincipal Investigator
- Principal Investigator
  
  Nagano Osamu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Keio University
Development of cancer therapy targeting the metabolism activated by EpCAM in cancer stem cells.Principal Investigator
- Principal Investigator
  
  NAGANO Osamu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
Analysis of the molecular mechanism of CD44-mediated glucose metabolism in cancer cells for the development of new cancer therapyPrincipal Investigator
- Principal Investigator
  
  NAGANO Osamu
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
Development of new cancer therapy to invasive cancer targeting hyaluronic acid matrix remodeling and CD44 ectodomain cleavagePrincipal Investigator
- Principal Investigator
  
  NAGANO Osamu
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Keio University
CD44細胞外ドメイン切断および細胞外マトリクス代謝阻害による癌細胞運動抑制Principal Investigator
- Principal Investigator
  
  永野修
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
  Kumamoto University

All 2022 2021 2020 2019 2018 2017 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] MEK inhibition suppresses metastatic progression of <i>KRAS</i> ‐mutated gastric cancer2022
- Author(s)
  Yamasaki Juntaro、Hirata Yuki、Otsuki Yuji、Suina Kentaro、Saito Yoshiyuki、Masuda Kenta、Okazaki Shogo、Ishimoto Takatsugu、Saya Hideyuki、Nagano Osamu
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 3 Pages: 916-925
- DOI
  10.1111/cas.15244
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16315, KAKENHI-PROJECT-21H02766, KAKENHI-PROJECT-21K19416, KAKENHI-PROJECT-21K19417, KAKENHI-PROJECT-20K18174, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-20H03531, KAKENHI-PROJECT-21K19535
[Journal Article] Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer2022
- Author(s)
  Tsuchihashi Kenji、Hirata Yuki、Yamasaki Juntaro、Suina Kentaro、Tanoue Kenro、Yae Toshifumi、Masuda Kenta、Baba Eishi、Akashi Koichi、Kitagawa Yuko、Saya Hideyuki、Nagano Osamu
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 30 Pages: 101246-101246
- DOI
  10.1016/j.bbrep.2022.101246
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-21H02766, KAKENHI-PROJECT-20K07638, KAKENHI-PROJECT-21K19417, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-20K18174
[Journal Article] Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy.2020
- Author(s)
  Otsuki Y, Yamasaki J, Suina K, Okazaki S, Koike N, Saya H, Nagano O.
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 1 Pages: 127-136
- DOI
  10.1111/cas.14224
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03583, KAKENHI-PROJECT-18J14396, KAKENHI-PROJECT-18K15223, KAKENHI-PROJECT-18K15602
[Journal Article] Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma.2019
- Author(s)
  Okazaki S, Umene K, Yamasaki J, Suina K, Otsuki Y, Yoshikawa M, Minami Y, Masuko T, Kawaguchi S, Nakayama H, Banno K, Aoki D, Saya H, Nagano O.
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 11 Pages: 3453-3463
- DOI
  10.1111/cas.14182
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03583, KAKENHI-PROJECT-18J14396, KAKENHI-PROJECT-18K15223
[Journal Article] Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells2018
- Author(s)
  Okazaki Shogo、Shintani Subaru、Hirata Yuki、Suina Kentaro、Semba Takashi、Yamasaki Juntaro、Umene Kiyoko、Ishikawa Miyuki、Saya Hideyuki、Nagano Osamu
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 73 Pages: 33832-33843
- DOI
  10.18632/oncotarget.26112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15223, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17H03583, KAKENHI-PROJECT-18J14396
[Journal Article] EGFR promotes glioma progression by regulating xCT and GluN2B-containing NMDA receptor signaling.2018
- Author(s)
  Suina K, Tsuchihashi K, Yamasaki J, Kamenori S, Shintani S, Hirata Y, Okazaki S, Sampetrean O, Baba E, Akashi K, Takahashi F, Takahashi K, Saya H, Nagano O.
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 12 Pages: 3874-3882
- DOI
  10.1111/cas.13826
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09669, KAKENHI-PROJECT-18K08185, KAKENHI-PROJECT-18K15215, KAKENHI-PROJECT-18K15223, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17H03583, KAKENHI-PROJECT-15K09230, KAKENHI-PROJECT-16K07124, KAKENHI-PROJECT-18J14396
[Journal Article] Development of a functional thyroid model based on an organoid culture system.2018
- Author(s)
  Saito Y, Onishi N, Takami H, Seishima R, Inoue H, Hirata Y, Kameyama K, Tsuchihashi K, Sugihara E, Uchino S, Ito K, Kawakubo H, Takeuchi H, Kitagawa Y, Saya H, Nagano O.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 497 Issue: 2 Pages: 783-789
- DOI
  10.1016/j.bbrc.2018.02.154
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07125, KAKENHI-PROJECT-17H03583, KAKENHI-PROJECT-15K06840, KAKENHI-PROJECT-18K07224, KAKENHI-PROJECT-17J04061
[Journal Article] CD44s signals the acquisition of the mesenchymal phenotype required for anchorage-independent cell survival in hepatocellular carcinoma.2014
- Author(s)
  Okabe H, Ishimoto T, Mima K, Nakagawa S, Hayashi H, Kuroki H, Imai K, Nitta H, Saito S, Hashimoto D, Chikamoto A, Ishiko T, Watanabe M, Nagano O, Beppu T, Saya H and Baba H
- Journal Title
  
  Br J Cancer
  
  Volume: 印刷中 Issue: 4 Pages: 958-66
- DOI
  10.1038/bjc.2013.759
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-23791549, KAKENHI-PROJECT-24590389, KAKENHI-PROJECT-24592008
[Journal Article] xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma.2013
- Author(s)
  Yoshikawa M, Tsuchihashi K, Ishimoto T, Yae T, Motohara T, Sugihara E, Onishi N, Masuko T, Yoshizawa K, Kawashiri S, Mukai M, Asoda S, Kawana H, Nakagawa T, Saya H, Nagano O.
- Journal Title
  
  Cancer Research
  
  Volume: 73 Pages: 1855-1866
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590389
[Journal Article] Redox regulation in stem-like cancer cells by CD44 variant isoforms.2013
- Author(s)
  Nagano O, Okazaki S, Saya H.
- Journal Title
  
  Oncogene
  
  Volume: 32 Issue: 44 Pages: 5191-5198
- DOI
  10.1038/onc.2012.638
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590389, KAKENHI-PLANNED-22130007
[Journal Article] CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence.2013
- Author(s)
  Hirata K, Suzuki H, Imaeda H, Matsuzaki J, Tsugawa H, Nagano O, Asakura K, Saya H, Hibi T
- Journal Title
  
  Br J Cancer
  
  Volume: 109 Issue: 2 Pages: 379-386
- DOI
  10.1038/bjc.2013.314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590389, KAKENHI-PROJECT-24659103, KAKENHI-PROJECT-25293178, KAKENHI-PROJECT-25460173
[Journal Article] Lysyl oxidase is induced by cell density-mediated cell cycle suppression via RB-E2F1-HIF-1a axis.2013
- Author(s)
  Goto TM, Arima Y, Nagano O, Saya H.
- Journal Title
  
  Cell Structure and Function
  
  Volume: 38 Pages: 9-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590389
[Journal Article] In vivo pH monitoring using boron doped diamond microelectrode and silver needles: Application to stomach disorder diagnosis.2013
- Author(s)
  Fierro S, Seishima R, Nagano O, Saya H and Einaga Y
- Journal Title
  
  Sci Rep
  
  Volume: 3 Issue: 1 Pages: 3257-3257
- DOI
  10.1038/srep03257
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24590389
[Journal Article] Gene expression profile of a newly established choriocarcinoma cell line, iC(3)-1, compared to existing choriocarcinoma cell lines and normal placenta.2013
- Author(s)
  Kobayashi Y, Banno K, Shimizu T, Ueki A, Tsuji K, Masuda K, Kisu I, Nomura H, Tominaga E, Nagano O, Saya H, Aoki D.
- Journal Title
  
  Placenta
  
  Volume: 34 Issue: 2 Pages: 110-118
- DOI
  10.1016/j.placenta.2012.11.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590389, KAKENHI-PROJECT-24592530
[Journal Article] Functional role of CD44v-xCT system in the development of spasmolytic polypeptide-expressing metaplasia2013
- Author(s)
  Wada T, Ishimoto T, Seishima R, Tsuchihashi K, Yoshikawa M, et al
- Journal Title
  
  Cancer Science
  
  Volume: 104 Issue: 10 Pages: 1323-9
- DOI
  10.1111/cas.12236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J06428, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24590389, KAKENHI-PROJECT-24591912
[Journal Article] In vivo assessment of cancerous tumors using boron doped diamond microelectrode.2012
- Author(s)
  Fierro S, Yoshikawa M, Nagano O, Yoshimi K, Saya H, Einaga Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 2 Issue: 1 Pages: 901-901
- DOI
  10.1038/srep00901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590389
[Journal Article] CD44s regulates the TGF-b-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma.2012
- Author(s)
  Mima K, Okabe H, Ishimoto T, Hayashi H, Nakagawa S, Kuroki H, Watanabe M, Beppu T, Tamada M, Nagano O, Saya H, Baba H
- Journal Title
  
  Cancer Research
  
  Volume: 72 Pages: 3414-3423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590389
[Journal Article] Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.2012
- Author(s)
  Yae T, Tsuchihashi K, Ishimoto T, Motohara T, Yoshikawa M, Yoshida GJ, Wada T, Masuko T,Mogushi K, Tanaka H, Osawa T, Kanki Y, et al
- Journal Title
  
  Nature Communications
  
  Volume: 6;3 Issue: 1 Pages: 883-883
- DOI
  10.1038/ncomms1892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310117, KAKENHI-PROJECT-23701047, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-24590389, KAKENHI-PROJECT-24591176, KAKENHI-PROJECT-24591912, KAKENHI-PROJECT-24710227, KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130007, KAKENHI-PUBLICLY-24116509
[Journal Article] Reactive Oxygen Species-Induced Autophagic Degradation of Helicobacter pylori CagA Is Specifically Suppressed in Cancer Stem-like Cells2012
- Author(s)
  Tsugawa H, Suzuki H, Saya H, Hatakeyama M, Hirayama T, Hirata K, Nagano 0, Matsuzaki J, et al.
- Journal Title
  
  Cell Host & Microbe
  
  Volume: 12 Issue: 6 Pages: 764-777
- DOI
  10.1016/j.chom.2012.10.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06306, KAKENHI-PROJECT-22300169, KAKENHI-PROJECT-22390084, KAKENHI-PROJECT-23790156, KAKENHI-PROJECT-24249046, KAKENHI-PROJECT-24590389, KAKENHI-PROJECT-24659103, KAKENHI-PROJECT-24659199, KAKENHI-PLANNED-22130007
[Journal Article] Modulation of Glucose Metabolism by CD44 Contributes to Antioxidant Status and Drug Resistance in Cancer Cells2011
- Author(s)
  Tamada M, Nagano O, Tateyama S, Ohmura M, Yae T, Ishimoto T, Sugihara E, Onishi N, Yamamoto T, Yanagawa H, Suematsu M, Saya H
- Journal Title
  
  Cancer Research
  
  Volume: 72 Pages: 1438-1448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790326
[Journal Article] Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction.2010
- Author(s)
  Takahashi E, Nagano O, Ishimoto T, Yae T, Suzuki Y, Shinoda T, Nakamura S, Niwa S, Ikeda S, Koga H, Tanihara H, Saya H.
- Journal Title
  
  J Biol Chem. 285
  
  Pages: 4060-4073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770161
[Journal Article] CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis.2010
- Author(s)
  Ishimoto T, Oshima H, Oshima M, Kai K, Torii R, Masuko T, Baba H, Saya H, Nagano O.
- Journal Title
  
  Ishimoto T, Oshima H, Oshima M, Kai K, Torii R, Masuko T, Baba H, Saya H and Nagano O. Cancer Sci. 101
  
  Pages: 673-678
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20770161
[Presentation] Novel approach for cancer therapy by simultaneous targeting of xCT-dependent cystine transport and aldehyde dehydrogenase activity2022
- Author(s)
  Osamu Nagano
- Organizer
  Redox Week in Sendai 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19417
[Presentation] Development of cancer therapy by simultaneous targeting of cystine-glutamate antiporter xCT and aldehyde dehydrogenase2022
- Author(s)
  Osamu Nagano
- Organizer
  The Cold Spring Harbor Asia conference on Iron, Reactive Oxygen Species & Ferroptosis in Life, Death & Disease, AWAJI, JAPAN
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02766
[Presentation] がん転移におけるフェロトーシス抵抗性2022
- Author(s)
  永野修
- Organizer
  第31回日本がん転移学会学術集会・総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19417
[Presentation] Novel approach for cancer therapy by simultaneous targeting of xCT-dependent cystine transport and aldehyde dehydrogenase activity2022
- Author(s)
  Osamu Nagano
- Organizer
  Redox Week in Sendai 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02766
[Presentation] シスチントランスポーターxCTとALDHを標的とした新しいがん治療2022
- Author(s)
  永野修
- Organizer
  日本薬物動態学会第37回年会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02766
[Presentation] シスチントランスポーターxCTとALDHを標的とした新しいがん治療2022
- Author(s)
  永野修
- Organizer
  日本薬物動態学会第37回年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19417
[Presentation] Development of cancer therapy by simultaneous targeting of cystine-glutamate antiporter xCT and aldehyde dehydrogenase2022
- Author(s)
  Osamu Nagano
- Organizer
  The Cold Spring Harbor Asia conference on Iron, Reactive Oxygen Species & Ferroptosis in Life, Death & Disease, AWAJI, JAPAN
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19417
[Presentation] がん転移におけるフェロトーシス抵抗性2022
- Author(s)
  永野修
- Organizer
  第31回日本がん転移学会学術集会・総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02766
[Presentation] Therapeutic targeting of redox system in cancer stem cells2021
- Author(s)
  永野修
- Organizer
  第80回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02766
[Presentation] Therapeutic targeting of redox system in cancer stem cells2021
- Author(s)
  永野修
- Organizer
  第80回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K19417
[Presentation] xCT阻害剤抵抗性を示す癌細胞に対してxCT阻害剤と合成致死を誘導する薬剤の同定2019
- Author(s)
  永野　修
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H03583
[Presentation] 癌細胞に鉄依存性細胞死を誘導するxCT標的治療とその抵抗性を克服する薬剤の探索2018
- Author(s)
  永野修
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H03583
[Presentation] Cancer treatment strategy targeting antioxidant system potentiated by CD44v-xCT in stem-like cancer cells.2017
- Author(s)
  Osamu Nagano
- Organizer
  10th international BioMedical Transporters Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03583
[Presentation] Redox regulation in stem-like cancer cells by CD44v2014
- Author(s)
  永野修
- Organizer
  第73回日本がん学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-07-31
- Data Source
  KAKENHI-PROJECT-24590389
[Presentation] がん幹細胞において活性化されるCD44v-xCTを介した抗酸化システムを標的とするがん治療戦略2014
- Author(s)
  永野修
- Organizer
  第37回日本分子生物学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-24590389
[Presentation] 酸化ストレス回避機構を標的としたがん幹細胞治療戦略2014
- Author(s)
  永野修
- Organizer
  第30回日本DDS学会学術総会
- Place of Presentation
  慶應義塾大学　薬学部　芝共立キャンパス（東京都港区）
- Year and Date
  2014-07-31
- Data Source
  KAKENHI-PROJECT-24590389
[Presentation] Cancer treatment strategy targeting antioxidant system potentiated by CD44v-xCT in stem-like cancer cells.2014
- Author(s)
  永野修
- Organizer
  第33回　札幌国際がんシンポジウム
- Place of Presentation
  ロイトン札幌(北海道札幌市)
- Year and Date
  2014-06-28
- Invited
- Data Source
  KAKENHI-PROJECT-24590389
[Presentation] Impact of CD44 Variant Form in Gastric Cancer2011
- Author(s)
  永野修
- Organizer
  SGCC 4th Annual Scientific Meeting
- Place of Presentation
  National University of Singapore(シンガポール)(招待講演)
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-22790326
[Presentation] Impact of CD44 Variant Form in Gastric Cancer2011
- Author(s)
  永野修
- Organizer
  SGCC 4th Annual Scientific Meeting
- Place of Presentation
  National University of Singapore(シンガポール)
- Year and Date
  2011-07-06
- Data Source
  KAKENHI-PROJECT-22790326
[Presentation] CD44バリアントアイソフォームはシスチントランスポーターxCTの安定化を誘導し癌細胞の抗酸化システムを制御する2011
- Author(s)
  永野修
- Organizer
  第4回SYMPHONY研究会
- Place of Presentation
  ホテルメトロポリタンエドモント(東京)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-22790326
[Presentation] CD44 variant isoform regulates antioxidant status in cancer cells via cystine transporter xCT stabilization2011
- Author(s)
  永野修
- Organizer
  第29回骨代謝学会
- Place of Presentation
  グランキューブ大阪(大阪)
- Year and Date
  2011-07-30
- Data Source
  KAKENHI-PROJECT-22790326
[Presentation] CD44 variant isoform regulates antioxidant status in cancer cells via cystine transporter xCT stabilization2011
- Author(s)
  永野修
- Organizer
  第26回日本整形外科学会
- Place of Presentation
  ベイシア文化ホール(群馬)
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-22790326
[Presentation] CD44バリアントアイソフォームはシスチントランスポーターxCTの安定化を誘導し癌細胞の抗酸化システムを制御する2011
- Author(s)
  永野修
- Organizer
  第4回SYMPHONY研究会
- Place of Presentation
  ホテルメトロポリタンエドモント(東京)(招待講演)
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-22790326
[Presentation] CD44 variant isoform regulates antioxidant status in cancer cells via cystine transporter xCT stabilization2011
- Author(s)
  永野修
- Organizer
  第70回日本癌学会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22790326
[Presentation] CD44 variant isoform regulates antioxidant status in cancer cells via cystine transporter xCT stabilization2011
- Author(s)
  永野修
- Organizer
  第15回分子標的学会
- Place of Presentation
  ホテル日航東京(東京)
- Year and Date
  2011-06-24
- Data Source
  KAKENHI-PROJECT-22790326
[Presentation] 胃癌幹細胞様細胞の拡大および腫瘍進展におけるCD44の役割2010
- Author(s)
  永野修、石本崇胤、佐谷秀行
- Organizer
  第9回日本再生医療学会総会
- Place of Presentation
  広島国際会議場
- Year and Date
  2010-03-19
- Data Source
  KAKENHI-PROJECT-20770161
[Presentation] 胃癌幹細胞様細胞の拡大および腫瘍進展におけるCD44の役割2010
- Author(s)
  永野修、石本崇胤、佐谷秀行
- Organizer
  第9回日本医療学会総会
- Place of Presentation
  広島国際会議場
- Year and Date
  2010-03-19
- Data Source
  KAKENHI-PROJECT-20770161
[Presentation] The role of CD44 in the expansion of gastric stem-like tumor cells2010
- Author(s)
  永野修
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  リーガロイヤルホテル大阪
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22790326
[Presentation] 胃癌幹細胞様細胞の拡大および腫瘍進展におけるCD44の役割2009
- Author(s)
  永野修、石本崇胤、甲斐千晴、佐谷秀行
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-05-01
- Data Source
  KAKENHI-PROJECT-20770161
[Presentation] 胃癌幹細胞様細胞の拡大および腫瘍進展におけるCD44の役割2009
- Author(s)
  永野修
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  第98回日本病理学会総会、国立京都国際会館
- Year and Date
  2009-05-01
- Data Source
  KAKENHI-PROJECT-20770161
[Presentation] 胃癌幹細胞増殖および腫瘍進展におけるCD44の役割2008
- Author(s)
  永野修
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20770161
[Presentation] CD44細胞外ドメイン切断機構とその生物学的意義2007
- Author(s)
  永野修
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-18790225
[Presentation] CD44バリアントアイソフォームを介した腫瘍形成および癌転移機構の解明
- Author(s)
  永野　修
- Organizer
  日本放射線影響学会
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-24590389
[Presentation] The functional role of CD44 variant in cancer metastasis
- Author(s)
  永野　修
- Organizer
  日本臨床口腔病理学会
- Place of Presentation
  文京区
- Invited
- Data Source
  KAKENHI-PROJECT-24590389
[Presentation] Redox regulation in stem-like cancer cells by CD44v
- Author(s)
  永野　修、佐谷秀行
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24590389
[Presentation] Redox regulation in stem-like cancer cells by CD44v
- Author(s)
  永野　修
- Organizer
  第11回日本臨床腫瘍学会
- Place of Presentation
  東北大学百周年記念会館
- Data Source
  KAKENHI-PROJECT-24590389
[Presentation] 酸化ストレス回避機構を標的とした癌幹細胞治療戦略
- Author(s)
  永野　修
- Organizer
  第17回日本がん分子標的治療学会学術集会
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-24590389

1. 莇生田整治 (80296706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 吉川桃子 (50570967)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 佐谷秀行 (80264282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. KANKI Yasuharu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. ONISHI Nobuyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 岡崎章悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 和田洋一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 高橋和久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 高橋史行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nagano Osamu 永野 修

NAGANO Osamu 永野 修

Research Projects

Research Products

Co-Researchers

口腔癌のエクソソームとCD47スプライシングアイソフォームによる免疫逃避の解明

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Elucidation of mechanisms of xCT-mediated cancer therapy resistance accompanied with metabolic reprograming and cancer stem cell propertyPrincipal Investigator

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Development of the therapy targeted to the vulnerability of SMARCA4-mutant lung cancer cells to ferroptosisPrincipal Investigator

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Elucidation of the mechanism of the induction of ferroptosis by xCT inhibitor and its antitumor effect in small cell lung cancerPrincipal Investigator

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Development of cancer therapy targeting the metabolism activated by EpCAM in cancer stem cells.Principal Investigator

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Analysis of the molecular mechanism of CD44-mediated glucose metabolism in cancer cells for the development of new cancer therapyPrincipal Investigator

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Development of new cancer therapy to invasive cancer targeting hyaluronic acid matrix remodeling and CD44 ectodomain cleavagePrincipal Investigator

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CD44細胞外ドメイン切断および細胞外マトリクス代謝阻害による癌細胞運動抑制Principal Investigator

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[Journal Article] MEK inhibition suppresses metastatic progression of <i>KRAS</i> ‐mutated gastric cancer2022

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[Journal Article] Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer2022

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[Journal Article] Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy.2020

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[Journal Article] Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma.2019

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[Journal Article] Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells2018

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[Journal Article] EGFR promotes glioma progression by regulating xCT and GluN2B-containing NMDA receptor signaling.2018

Author(s)

Nagano Osamu 永野修

NAGANO Osamu 永野修