INOUE Tsutomu 井上勉

Researcher Number	30406475
Other IDs
Affiliation (Current)	2022: 埼玉医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2013 – 2020: 埼玉医科大学, 医学部, 准教授 2016: 埼玉医科大学, 腎臓内科, 准教授 2010 – 2012: 埼玉医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Radiation science / Kidney internal medicine / Basic Section 53040:Nephrology-related Except Principal Investigator Kidney internal medicine / Urology / Basic Section 53040:Nephrology-related
Keywords	Principal Investigator 慢性腎臓病 / 線維化 / 腎線維化 / CCN2 / 虚血 / MRI / BOLD / DWI / ASL / 低酸素 … More / インテグリン / 内科 / 腎臓内科 / focal adhesion kinase … More Except Principal Investigator 腎線維化 / 線維化 / 尿細管上皮細胞 / 遺伝子改変動物 / 線維芽細胞 / CCN2 / 細胞周期 / 老化 / NFkB 経路 / NFkB / ポドサイト / NFkBシグナル / 糸球体硬化 / CKD / ノックインマウス / 腎癌 / 蛋白尿 / 分子標的治療薬 / チロシンキナーゼ阻害薬 / 進行性腎癌 / 転移性腎癌 / 分子標的薬 / 急性腎障害 / 慢性腎臓病 / アポトーシス / カスパーゼ / 急性腎障害(AKI) / 慢性腎臓病(CKD) / クロト / ＴＲＰＣ６ / ネフリン / アンギオテンシン / 糖尿病 / 腎肥大 / 高血圧 / ＥＭＴ / 糸球体 / WNT / 上皮間葉転移 / PTH / ビタミンD / TGFβ / 形質転換 / 増殖因子 Less

急性腎障害の遷延機序解明を通した慢性腎臓病の重症化抑制法の開発
- Principal Investigator
  
  岡田浩一
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Saitama Medical University
CCN2機能制御による慢性・急性腎障害の新規治療薬の開発Principal Investigator
- Principal Investigator
  
  井上勉
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Saitama Medical University
Pathogenesis and treatment of tubular epithelium-mediated AKI to CKD transition
- Principal Investigator
  
  Okada Hirokazu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Saitama Medical University
Development of a new treatment approach for chronic kidney disease by controlling CCN2 functionPrincipal Investigator
- Principal Investigator
  
  Inoue Tsutomu
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Saitama Medical University
Clinical analysis of urinary biomarkers predictive of renal injury due to tyrosine kinase inhibitors for advanced renal cell carcinoma
- Principal Investigator
  
  oyama masafumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Saitama Medical University
Generation of anti-fibrotic therapy to combat progression of CKD via CCN2 blockade
- Principal Investigator
  
  Okada Hirokazu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Saitama Medical University
Research on renoprotective effects by klotho protein
- Principal Investigator
  
  Takenaka Tsuneo
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  International University of Health and Welfare
Functional MRI for CKDPrincipal Investigator
- Principal Investigator
  
  INOUE Tsutomu
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Saitama Medical University
Effects of renal tissue-specific NFkB blockade on aging kidneys
- Principal Investigator
  
  OKADA Hirokazu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Saitama Medical University

All 2021 2020 2019 2018 2017 2016 2015 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Klotho supplementation attenuates blood pressure and albuminuria in murine model of IgA nephropathy2021
- Author(s)
  Takenaka Tsuneo、Hasan Arif、Marumo Takeshi、Kobori Hiroyuki、Inoue Tsutomu、Miyazaki Takashi、Suzuki Hiromichi、Nishiyama Akira、Ishii Naohito、Hayashi Matsuhiko
- Journal Title
  
  Journal of Hypertension
  
  Volume: Publish Ahead of Print Pages: 1-10
- DOI
  10.1097/hjh.0000000000002845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08731, KAKENHI-PROJECT-20K08641
[Journal Article] Tocilizumab-induced immunocomplex glomerulonephritis: a report of two cases2020
- Author(s)
  Fukaya Daichi、Inoue Tsutomu、Kogure Yuta、Kajiyama Hiroshi、Ishizawa Keisuke、Seto Takeru、Hasegawa Hajime、Mimura Toshihide、Okada Hirokazu
- Journal Title
  
  CEN Case Reports
  
  Volume: 9 Pages: 318-325
- DOI
  10.1007/s13730-020-00478-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08731
[Journal Article] Glomerular Solidification Is Associated With Nephritis-Related Clinical Parameters in IgA Nephropathy2019
- Author(s)
  Inoue Tsutomu、Luo Yankun、Seto Takeru、Suzuki Hiromichi、Okada Hirokazu
- Journal Title
  
  Ren Fail
  
  Volume: 41 Pages: 893-898
- DOI
  10.1080/0886022x.2019.1665545
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08731, KAKENHI-PROJECT-16K09627
[Journal Article] Cellular Communication Network Factor 2 (CCN2) Promotes the Progression of Acute Kidney Injury to Chronic Kidney Disease2019
- Author(s)
  Inoue Tsutomu、Kusano Takeru、Amano Hiroaki、Nakamoto Hidetomo、Okada Hirokazu
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 517 Pages: 96-102
- DOI
  10.1016/j.bbrc.2019.07.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08731, KAKENHI-PROJECT-16K09627
[Journal Article] Klotho suppresses the renin-angiotensin system in adriamycin nephropathy.2017
- Author(s)
  Takenaka T, Inoue T, Miyazaki T, Kobori H, Nishiyama A, Ishii N, Hayashi M, Suzuki H.
- Journal Title
  
  Nephrol Dial Transplant
  
  Volume: 印刷中 Pages: 791-800
- DOI
  10.1093/ndt/gfw340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461229, KAKENHI-PROJECT-15K09271, KAKENHI-PROJECT-16K09625
[Journal Article] Xeno-Klotho Inhibits Parathyroid Hormone Signaling.2016
- Author(s)
  Tsuneo Takenaka, Tsutomu Inoue, Takashi Miyazaki, Matsuhiko Hayashi, Hiromichi Suzuki.
- Journal Title
  
  J Bone Miner Res.
  
  Volume: 31(2) Pages: 455-62
- DOI
  10.1002/jbmr.2691
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461229
[Journal Article] 【慢性低酸素状態の腎臓】 MRIによる低酸素の画像診断2013
- Author(s)
  井上勉、小澤栄人、岡田浩一、鈴木洋通
- Journal Title
  
  医学のあゆみ
  
  Volume: 244 Pages: 309-3014
- Data Source
  KAKENHI-PROJECT-23791442
[Journal Article] 3テスラ磁気共鳴装置を用いたテンソル画像による糖尿病性腎症の早期診断の研究2013
- Author(s)
  小澤栄人、井上勉、田中淳司
- Journal Title
  
  埼玉医科大学雑誌
  
  Volume: 40 Pages: 16-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791442
[Journal Article] 【腎臓病のup to date-病態に基づいた治療の最前線-】腎臓病の病態　画像診断2013
- Author(s)
  井上勉、小澤栄人、岡田浩一、鈴木洋通
- Journal Title
  
  カレントテラピー
  
  Volume: 31 Pages: 587-592
- Data Source
  KAKENHI-PROJECT-23791442
[Journal Article] 【最近の腎尿路画像検査】ファンクショナルMRI2013
- Author(s)
  井上勉、小澤栄人、鈴木洋通
- Journal Title
  
  腎臓
  
  Volume: 36 Pages: 22-28
- Data Source
  KAKENHI-PROJECT-23791442
[Journal Article] Is there no future for renal BOLD-MRI?2012
- Author(s)
  Tsutomu Inoue, Eito Kozawa, Hirokazu Okada, Hiromichi Suzuki
- Journal Title
  
  Kidney International
  
  Volume: 82 Pages: 934-934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791442
[Journal Article] Basic nephrology　検査・診断腎機能の可視化2012
- Author(s)
  井上勉、小澤栄人、鈴木洋通
- Journal Title
  
  Annual Review腎臓
  
  Volume: 2012 Pages: 93-99
- Data Source
  KAKENHI-PROJECT-23791442
[Journal Article] Noninvasive Evaluation of Kidney Hypoxia and Fibrosis Using Magnetic Resonance Imaging2011
- Author(s)
  Tsutomu Inoue, Eito Kozawa, Hirokazu Okada, Kouichi Inukai, Shinichi Watanabe, Tomohiro Kikuta, Yusuke Watanabe, Tsuneo Takenaka, Shigehiro Katayama, Junji Tanaka and Hiromichi Suzuki
- Journal Title
  
  Journal of the American Society of Nephrology
  
  Volume: 22 Pages: 1429-1434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791442
[Journal Article] 【慢性腎臓病　CKDの新たなパラダイムを求めて】 CKDの診断と評価　CKDの画像診断　新たな試み2011
- Author(s)
  井上勉, 小澤栄人, 竹中恒夫, 鈴木洋通
- Journal Title
  
  内科
  
  Volume: 107 Pages: 214-217
- Data Source
  KAKENHI-PROJECT-23791442
[Journal Article] BOLD MRIを用いた腎機能評価法の確立2011
- Author(s)
  井上勉, 小澤栄人, 岡田浩一, 竹中恒夫, 鈴木洋通
- Journal Title
  
  埼玉医科大学雑誌
  
  Volume: 38 Pages: 39-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791442
[Presentation] CCN2 Module IV-Derived Decoy Peptides Attenuate Renal Fibrogenesis Through Inhibition of FAK Pathway in the Tubular Epithelium2019
- Author(s)
  Hiroaki Amano, Tsutomu Inoue, Hirokazu Okada
- Organizer
  Annual Meeting of American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08731
[Presentation] CCN2 Module IV-Derived Decoy Peptides Attenuate Renal Fibrogenesis Through Inhibition of FAK Pathway in the Tubular Epithelium2019
- Author(s)
  Hiroaki Amano, Tsutomu Inoue, Hirokazu Okada
- Organizer
  Annual Meeting of American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09627
[Presentation] CCN2 module 4はFAKのリン酸化を介して腎線維化を促進する2019
- Author(s)
  天野博明、井上勉、草野武、岡田浩一
- Organizer
  日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08731
[Presentation] CCN2 module 4はFAKのリン酸化を介して腎線維化を促進する2019
- Author(s)
  天野博明、井上勉、草野武、岡田浩一
- Organizer
  日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09627
[Presentation] CCN2 module-IV promotes renal fibrosis through activation of the FAK pathway in the tubular epithelium2018
- Author(s)
  天野博明、井上勉、草野武、岡田浩一
- Organizer
  The annual meeting ofthe American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09626
[Presentation] CCN2 Module-IV Promotes Renal Fibrosis Through Activation of the FAK Pathway in the Tubular Epithelium2018
- Author(s)
  Hiroaki Amano, Tustomu Inoue, Hirokazu Okada
- Organizer
  Annual meeting of American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09627
[Presentation] 初代皮膚線維芽細胞におけるCCN2 module-IVの作用機序について2018
- Author(s)
  天野博明、井上勉、草野武、岡田浩一
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16K09626
[Presentation] 初代皮膚線維芽細胞におけるCCN2 module-IVの作用機序について2018
- Author(s)
  天野博明, 井上勉, 草野武, 岡田浩一
- Organizer
  日本腎臓学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09627
[Presentation] Module IV-defected mutant CCN2 knock-in transgenic mice grow and develop normally, but fibrotic properties are attenuated in a number of kidney diseases.2017
- Author(s)
  天野博明、井上勉、草野武、岡田浩一
- Organizer
  The annual meeting ofthe American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09626
[Presentation] Module IV-defected mutant CCN2 knock-in transgenic mice grow and develop normally, but fibrotic properties are attenuated in a number of kidney diseases.2017
- Author(s)
  Tsutomu Inoue, Ono Atsushi, Hirokazu Okada.
- Organizer
  Annual Meeting of American Society of Nephrology 2018 (Kidney Week 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09627
[Presentation] 尿細管上皮細胞のCaspase活性とCCN2発現はAKIからCKDへの移行を修飾する2016
- Author(s)
  草野武、井上勉、中元秀友、岡田浩一
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K09626
[Presentation] Klotho suppresses the renin-angiotensin system in adriamycin nephropathy.2016
- Author(s)
  Takenaka T, Inoue T, Miyazaki T, Kobori H, Nishiyama A, Ishii N, Hayashi M, Suzuki H.
- Organizer
  European Renal Association
- Place of Presentation
  ウイーン
- Year and Date
  2016-05-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461229
[Presentation] 尿細管上皮細胞のCaspase活性とCCN2発現はAKIからCKDへの移行を修飾する2016
- Author(s)
  草野武, 井上勉, 中元秀友, 岡田浩一
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K09627
[Presentation] CCN2第4モジュールが腎線維化に重要である2015
- Author(s)
  井上勉
- Organizer
  第58回日本腎臓学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-25461228
[Presentation] Klotho suppresses EMT in Adriamycin nephropathy2015
- Author(s)
  Tsuneo Takenaka, Tsutomu Inoue, Takashi Miyazaki, Matsuhiko Hayashi, Hiromichi Suzuki
- Organizer
  American Society of Nephrology Kidney Week 2015
- Place of Presentation
  San Diego
- Year and Date
  2015-11-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461229
[Presentation] MRIによる非侵襲的CKD評価の試み2012
- Author(s)
  井上勉
- Organizer
  日本医学放射線学会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-23791442
[Presentation] Targeted Inhibition of NF-kB Activation in Tubular Epithelia Protects Mice Against Renal Fibrogenesis Following NTN2011
- Author(s)
  T.Inoue, 他
- Organizer
  Annual Meeting of the American Society of Nephrology, 2011
- Place of Presentation
  Philadelphia, PA, USA
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-22590897
[Presentation] ここまで見える　腎疾患イメージングの最前線 MRIを用いた非侵襲的CKD評価の試み
- Author(s)
  井上勉
- Organizer
  日本腎臓学会学術総会(招待講演)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23791442
[Presentation] A Module IV-Defective CCN2 Mutant and Module IV-Derived Decoy Peptides Attenuate Renal Fibrogenesis
- Author(s)
  Tsutomu Inoue, MD, PhD, Takeru Kusano, MD, Hiroaki Amano, MD, Kei Sugiyama, MD, Hiromichi Suzuki, MD, PhD, Hirokazu Okada, MD, PhD
- Organizer
  Kidney Week 2014, The annual meeting of the American Society of Nephrology
- Place of Presentation
  Philadelphia Convention Center, Philadelphia, PA, USA
- Year and Date
  2014-11-13 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-25461228
[Presentation] 3テスラMRIによるASL（arterial spin labeling）を用いた腎灌流量の評価
- Author(s)
  井上勉、小澤栄人、石川雅浩、菊田知宏、渡辺裕輔、高根裕史、小林直樹、鈴木洋通、岡田浩一
- Organizer
  第112回日本内科学会講演会
- Place of Presentation
  みやこめっせ（京都府京都市）
- Year and Date
  2015-04-10 – 2015-04-12
- Data Source
  KAKENHI-PROJECT-23791442
[Presentation] 機能的イメージングの腎疾患病態解明、臨床への応用 Functional-MRIを用いた腎線維化と虚血の非侵襲的評価
- Author(s)
  岡田浩一、井上勉、小澤英人
- Organizer
  第57回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-07-04 – 2014-07-06
- Invited
- Data Source
  KAKENHI-PROJECT-23791442

1. OKADA Hirokazu (60233342)

# of Collaborated Projects: 7 results

# of Collaborated Products: 16 results
2. oyama masafumi (70276351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Takenaka Tsuneo (90179656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. Miyazaki Takshi (30265417)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. 城武卓 (10528805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MIYAWAKI Atsushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HASAN Ul arif

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. Nishiyama Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. Kobori Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. Ishii Naohito

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. Hayashi Matsuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. Suzuki Hiromichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 丸茂丈史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

INOUE Tsutomu 井上 勉

Research Projects

Research Products

Co-Researchers

急性腎障害の遷延機序解明を通した慢性腎臓病の重症化抑制法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

CCN2機能制御による慢性・急性腎障害の新規治療薬の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathogenesis and treatment of tubular epithelium-mediated AKI to CKD transition

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a new treatment approach for chronic kidney disease by controlling CCN2 functionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical analysis of urinary biomarkers predictive of renal injury due to tyrosine kinase inhibitors for advanced renal cell carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Generation of anti-fibrotic therapy to combat progression of CKD via CCN2 blockade

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on renoprotective effects by klotho protein

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional MRI for CKDPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of renal tissue-specific NFkB blockade on aging kidneys

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Klotho supplementation attenuates blood pressure and albuminuria in murine model of IgA nephropathy2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tocilizumab-induced immunocomplex glomerulonephritis: a report of two cases2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glomerular Solidification Is Associated With Nephritis-Related Clinical Parameters in IgA Nephropathy2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cellular Communication Network Factor 2 (CCN2) Promotes the Progression of Acute Kidney Injury to Chronic Kidney Disease2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Klotho suppresses the renin-angiotensin system in adriamycin nephropathy.2017

Author(s)

INOUE Tsutomu 井上勉

[Journal Article] 【腎臓病のup to date-病態に基づいた治療の最前線-】腎臓病の病態　画像診断2013

[Journal Article] 【最近の腎尿路画像検査】ファンクショナルMRI2013

[Journal Article] Basic nephrology　検査・診断腎機能の可視化2012

[Journal Article] 【慢性腎臓病　CKDの新たなパラダイムを求めて】 CKDの診断と評価　CKDの画像診断　新たな試み2011