Maeda Jun 前田純

… Alternative Names

MAEDA Jun 前田純

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Researcher Number	30415426
External Links
Affiliation (based on the past Project Information) *help	2017 – 2019: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所脳機能イメージング研究部, 主任研究員(任常) 2015: 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 2015: 放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 2014: 独立行政法人放射線医学総合研究所分子神経イメージンググループ, 主任研究員 2008 – 2014: National Institute of Radiological Sciences, 分子イメージング研究センター, 主任研究員 2007: National Institute of Radiological Sciences, 分子イメージング研究センター, 主任研究員 2006: 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員
Review Section/Research Field	Principal Investigator Physical pharmacy / Radiation science / Pharmacology in pharmacy / General pharmacology Except Principal Investigator Biological Sciences / Cerebral neurosurgery
Keywords	Principal Investigator ミクログリア / 認知症 / PET / プリン受容体 / 陽電子撮像法 / アルツハイマー病 / 末梢性ベンゾジアゼピン受容体 / トランスレーショナルリサーチ / 放射線 / 脳・神経 … More / 神経炎症 / 陽電子断層撮像法 / アミノ酸トランスポーター / 糖質コルチコイド / 膵臓 / 脳 / 炎症 / てんかん / セロトニン / ストレス / うつ病 / 陽電子断層撮像 / キヌレニン / トリプトファン / 陽電子断層撮像法(PET) / アデノシン受容体 / 陽電子断層撮像法（PET） / アデノシンA2a受容体 / P2Y12受容体 / 画像診断薬 / 多発性硬化症 / 陽電子断層撮像(PET) / イメージング / アストロサイト … More Except Principal Investigator オートファジー / アルツハイマー病 / モデル動物 / 神経炎症 / タウタンパク / イメージング / 薬学 / 脳疾患研究 / 認知症 / 生体分子 / 神経科学 / 神経移植 / 光学計測 / PET Less

Imaging of microglial functions by P2X7 and P2Y12 receptor PET ligandsPrincipal Investigator
- Principal Investigator
  
  Maeda Jun
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Elucidation for a role of kynurenine pathway on the pathogenesis of depressionPrincipal Investigator
- Principal Investigator
  
  Maeda Jun
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  National Institute of Radiological Sciences
In vivo PET and optical imaging of neurogenesis of neuronal circuit
- Principal Investigator
  
  INAJI Motoki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Tokyo Medical and Dental University
Molecular imaging of neurotoxic signaling in neurodegenerative disorders
- Principal Investigator
  
  Higuchi Makoto
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Radiological Sciences
Functional bioimaging of brain microglia by purine receptor PET ligandsPrincipal Investigator
- Principal Investigator
  
  MAEDA Jun
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  National Institute of Radiological Sciences
In vivo activated glia imaging by development of novel peripheral benzodiazepine receptor ligandsPrincipal Investigator
- Principal Investigator
  
  MAEDA Jun
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  National Institute of Radiological Sciences
神経変性過程における末梢性ベンゾジアゼピン受容体機能の解明Principal Investigator
- Principal Investigator
  
  前田純
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  National Institute of Radiological Sciences

[Book] 臨床精神薬理　第20巻9号〈特集〉向精神薬の多剤規制と減量・離脱の実際2017
- Author(s)
  前田　純、樋口　真人、須原　哲也
- Total Pages
  8
- Publisher
  星和書店
- ISBN
  9784791152391
- Data Source
  KAKENHI-PROJECT-17K10387
[Book] 専門医のための精神科臨床リュミエール26依存性・衝動制御障害の治療2011
- Author(s)
  前田純, 須原哲也
- Total Pages
  9
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-22590053
[Book] 認知症モデルマウスのイメージング,PET journal No.152011
- Author(s)
  前田純
- Publisher
  先端医療技術研究所
- Data Source
  KAKENHI-PROJECT-22590053
[Book] 物質依存の神経画像-PETを用いた研究,専門医のための精神科臨床リュミエール 26巻依存症・衝動制御障害の治療2011
- Author(s)
  前田純,須原哲也
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-22590053
[Journal Article] Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.2020
- Author(s)
  Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, Ono M, Seki C, Maeda J, Urushihata T, Minamihisamatsu T, Aoki I, Kawamura K, Zhang MR, Suhara T, Sahara N, Higuchi M.
- Journal Title
  
  J Neurosci.
  
  Volume: 40 Issue: 17 Pages: 3491-3501
- DOI
  10.1523/jneurosci.2880-19.2020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06542, KAKENHI-PROJECT-18K07777, KAKENHI-PROJECT-19K08005, KAKENHI-PUBLICLY-18H04752, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-17K10387, KAKENHI-PROJECT-19K06896, KAKENHI-PROJECT-20K15910, KAKENHI-PUBLICLY-19H05437
[Journal Article] In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg45102018
- Author(s)
  Ishikawa Ai、Tokunaga Masaki、Maeda Jun、Minamihisamatsu Takeharu、Shimojo Masafumi、Takuwa Hiroyuki、Ono Maiko、Ni Ruiqing、Hirano Shigeki、Kuwabara Satoshi、Ji Bin、Zhang Ming-Rong、Aoki Ichio、Suhara Tetsuya、Higuchi Makoto、Sahara Naruhiko
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 61 Issue: 3 Pages: 1037-1052
- DOI
  10.3233/jad-170509
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10387, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324, KAKENHI-PROJECT-15K06793, KAKENHI-PROJECT-15K09979, KAKENHI-PROJECT-16K21636, KAKENHI-PROJECT-16K19872
[Journal Article] Microglial Activation During Pathogenesis of Tauopathy in rTg4510 Mice: Implications for the Early Diagnosis of Tauopathy.2018
- Author(s)
  Naruhiko Sahara, Jun Maeda, Ai Ishikawa, Masaki Tokunaga, Tetsuya Suhara, Makoto Higuchi
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 64 Issue: s1 Pages: S353-S359
- DOI
  10.3233/jad-179933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10387, KAKENHI-PLANNED-26117008, KAKENHI-PROJECT-16H05324
[Journal Article] Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors2016
- Author(s)
  Kazumi Koga, Jun Maeda, Masaki Tokunaga, Masayuki Hanyu, Kazunori Kawamura, Mari Ohmichi, Toshio Nakamura, Yuji Nagai, Chie Seki, Yasuyuki Kimura, Takafumi Minamimoto, Ming-Rong Zhang, Toshimitsu Fukumura, Tetsuya Suhara, Makoto Higuchi
- Journal Title
  
  EJNMMI Research
  
  Volume: 6 Issue: 1 Pages: 1-14
- DOI
  10.1186/s13550-016-0170-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26861031, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-25460114, KAKENHI-PLANNED-15H05917
[Journal Article] [18F]FEBMP: Positron Emission Tomography Imaging of TSPO in a Model of Neuroinflammation in Rats, and in vitro Autoradiograms of the Human Brain2015
- Author(s)
  Tiwari AK, Ji B, Yui J, Fujinaga M, Yamasaki T, Xie L, Luo R, Shimoda Y, Kumata K, Zhang Y, Hatori A, Maeda J, Higuchi M, Wang F, Zhang MR.
- Journal Title
  
  Theranostics
  
  Volume: 26 Issue: 9 Pages: 961-9
- DOI
  10.7150/thno.12027
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09979, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] Development of 1-N-(11)C-Methyl-L- and -D-Tryptophan for pharmacokinetic imaging of the immune checkpoint inhibitor 1-Methyl-Tryptophan.2015
- Author(s)
  Xie L, Maeda J, Kumata K, Yui J, Zhang Y, Hatori A, Nengaki N, Wakizaka H, Fujinaga M, Yamasaki T, Shimoda Y, Higuchi M, Suhara T, Wang F, Zhang MR
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1 Pages: 16417-16417
- DOI
  10.1038/srep16417
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] Development of Novel PET Probes for Central 2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid Receptors.2015
- Author(s)
  Oi N, Tokunaga M, Suzuki M, Nagai Y, Nakatani Y, Yamamoto N, Maeda J, Minamimoto T, Zhang MR, Suhara T, Higuchi M
- Journal Title
  
  J Med Chem
  
  Volume: 58 Issue: 21 Pages: 8444-8462
- DOI
  10.1021/acs.jmedchem.5b00712
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] Quantification of central substance p receptor occupancy by aprepitant using small animal positron emission tomography2014
- Author(s)
  Endo T, Saijo T, Haneda E, Maeda J, Tokunaga M, Zhang MR, Kannami A, Asai H, Suzuki M, Suhara T, Higuchi M.
- Journal Title
  
  International Journal of Neuropsychopharmacology
  
  Volume: 18 Issue: 2 Pages: pyu030-pyu030
- DOI
  10.1093/ijnp/pyu030
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls2013
- Author(s)
  Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, Furumoto S, Kudo Y, Chang Q, Saido TC, Takashima A, Lewis J, Jang MK, Aoki I, Ito H, Higuchi M.
- Journal Title
  
  Neuron
  
  Volume: 79 Issue: 6 Pages: 1094-1108
- DOI
  10.1016/j.neuron.2013.07.037
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-23390297, KAKENHI-PROJECT-23591735, KAKENHI-PUBLICLY-24111562, KAKENHI-PROJECT-25670524
[Journal Article] A small-animal pharmacokinetic/pharmacodynamic PET study of central serotonin 1A receptor occupancy by a potential therapeutic agent for overactive bladder2013
- Author(s)
  Nakatani Y, Suzuki M, Tokunaga M, Maeda J, Sakai M, Ishihara H, Yoshinaga T, Takenaka O, Zhang MR, Suhara T, Higuchi M.
- Journal Title
  
  PLoS ONE
  
  Volume: 8 Issue: 9 Pages: e75040-e75040
- DOI
  10.1371/journal.pone.0075040
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.2013
- Author(s)
  Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T.
- Journal Title
  
  Neuropsychopharmacology
  
  Volume: 38(8) Issue: 8 Pages: 1409-25
- DOI
  10.1038/npp.2013.38
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-22380078, KAKENHI-PROJECT-22500342, KAKENHI-PROJECT-22651075, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23370079, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-23792018, KAKENHI-PUBLICLY-24111546, KAKENHI-PROJECT-24657008, KAKENHI-PROJECT-24791244, KAKENHI-PROJECT-25460114, KAKENHI-PLANNED-22125005
[Journal Article] Loss of branched O-mannosyl glycans in astrocytes accelerates remyelination2013
- Author(s)
  Kanekiyo K, Inamori K, Kitazume S, Sato K, Maeda J, Higuchi M, Kizuka Y, Korekane H, Matsuo I, Honke K, Taniguchi N
- Journal Title
  
  J. Neurosci.
  
  Volume: 33(24) Issue: 24 Pages: 10037-10047
- DOI
  10.1523/jneurosci.3137-12.2013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20249018, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235, KAKENHI-PROJECT-25430122, KAKENHI-PROJECT-25670166
[Journal Article] PET Applications in Animal Models of Neurodegenerative and Neuroinflammatory Disorders2012
- Author(s)
  Higuchi M, Maeda J, Ji B, Tokunaga M, Zhang MR, Maruyama M, Ono M, Fukumura T, Suhara T
- Journal Title
  
  Curr Top Behav Neurosci
  
  Volume: 11 Pages: 45-64
- DOI
  10.1007/7854_2011_167
- ISBN
  9783642287107, 9783642287114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590053, KAKENHI-PROJECT-22790835, KAKENHI-PROJECT-23390235, KAKENHI-PLANNED-23111009
[Journal Article] Molecular imaging of dementia2012
- Author(s)
  Mori T, Maeda J, Shimada H, Higuchi M, Shinotoh H, Ueno S, Suhara T
- Journal Title
  
  Psychogeriatrics
  
  Volume: 12(2) Issue: 2 Pages: 106-114
- DOI
  10.1111/j.1479-8301.2012.00409.x
- NAID
  10029785231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590053, KAKENHI-PROJECT-22790836, KAKENHI-PROJECT-23390235, KAKENHI-PLANNED-23111009
[Journal Article] Imaging for metabotropic glutamate receptor subtype 1 in rat and monkey brains using PET with [18F]FITM2012
- Author(s)
  Yamasaki T, Fujinaga M, Maeda J, Kawamura K, Yui J, Hatori A, Yoshida Y, Nagai Y, Tokunaga M, Higuchi M, Suhara T, Fukumura T, Zhang MR
- Journal Title
  
  Eur J Nucl Med Mol Imaging
  
  Volume: 39(4) Issue: 4 Pages: 632-641
- DOI
  10.1007/s00259-011-1995-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590053, KAKENHI-PROJECT-22591379
[Journal Article] Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology2012
- Author(s)
  Higuchi M, Iwata N, Matsuba Y, Takano J, Suemoto T, Maeda J, Ji B, Ono M, Staufenbiel M, Suhara T, Saido TC
- Journal Title
  
  FASEB J
  
  Volume: 26(3) Issue: 3 Pages: 1204-1217
- DOI
  10.1096/fj.11-187740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590053, KAKENHI-PROJECT-22790835, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] Characterization of 1-(2-[18F] fluoro-3-pyridyl)-4-(2-isopropyl-1-oxo- isoindoline-5-yl)-5-methyl-1H-1,2,3-triazole, a PET ligand for imaging the metabotropic glutamate receptor type 1 in rat and monkey brains2012
- Author(s)
  Fujinaga M, Maeda J, Yui J, Hatori A, Yamasaki T, Kawamura K, Kumata K, Yoshida Y, Nagai Y, Higuchi M, Suhara T, Fukumura T, Zhang MR
- Journal Title
  
  J Neurochem
  
  Volume: 121(1) Issue: 1 Pages: 115-24
- DOI
  10.1111/j.1471-4159.2011.07348.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590053, KAKENHI-PROJECT-22591379
[Journal Article] Central nervous system drug evaluation using positron emission tomography2011
- Author(s)
  Sekine M, Maeda J, Shimada H, Nogami T, Arakawa R, Takano H, Higuchi M, Ito H, Okubo Y, Suhara T
- Journal Title
  
  Clin Psychopharmacol Neurosci
  
  Volume: 9(1) Issue: 1 Pages: 9-16
- DOI
  10.9758/cpn.2011.9.1.9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590053, KAKENHI-PROJECT-22659212
[Journal Article] In Vivo Positron Emission Tomographic Imaging of Glial Responses to Amyloid-{beta} and Tau Pathologies in Mouse Models of Alzheimer's Disease and Related Disorders.2011
- Author(s)
  Maeda J
- Journal Title
  
  J Neurosci.
  
  Volume: 31 Pages: 4720-4730
- Data Source
  KAKENHI-PROJECT-22590053
[Journal Article] In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders2011
- Author(s)
  Maeda J, Zhang MR, Okauchi T, Ji B, Ono M, Hattori S, Kumata K, Iwata N, Saido TC, Trojanowski JQ, Lee VM, Staufenbiel M, Tomiyama T, Mori H, Fukumura T, Suhara T, Higuchi M
- Journal Title
  
  J Neurosci.
  
  Volume: 31(12) Issue: 12 Pages: 4720-4730
- DOI
  10.1523/jneurosci.3076-10.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590053, KAKENHI-PROJECT-22790835, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article]2011
- Author(s)
  樋口真人, 季斌, 前田純, 丸山将浩, 小野麻衣子, 澤田誠, 須原哲
- Journal Title
  
  アルツハイマー病とミクログリア臨床神経
  
  Volume: 51 Pages: 1031-1031
- Data Source
  KAKENHI-PROJECT-22590053
[Journal Article] In vivo and in vitro imaging of I_2 imidazoline receptors in the monkey brain2011
- Author(s)
  Kawamura K, Maeda J, Hatori A, Okauchi T, Nagai Y, Higuchi M, Suhara T, Fukumura T, Zhang MR
- Journal Title
  
  Synapse
  
  Volume: 65(5) Issue: 5 Pages: 452-455
- DOI
  10.1002/syn.20897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590053, KAKENHI-PLANNED-23111009, KAKENHI-PROJECT-23390235
[Journal Article] Design, synthesis, radiolabeling, and in vivo evaluation of carbon-11 labeled N-[2-[4-(3-cyanopyridin-2-yl)piperazin-1-yl]ethyl]-3-methoxybenzamide2010
- Author(s)
  Lacivita E, De Giorgio P, Lee IT, Rodeheaver SI, Weiss BA, Fracasso C, Caccia S, Berardi F, Perrone R, Zhang MR, Maeda J, Higuchi M, Suhara T, Schetz JA, Leopoldo M
- Journal Title
  
  a potential positron emission tomography tracer for the dopamine D4 receptors
  
  Volume: 53(20) Issue: 20 Pages: 7344-7355
- DOI
  10.1021/jm100925m
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590053
[Journal Article] In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis: Insights from neuroimaging research in humans and rodent models2010
- Author(s)
  Higuchi M, Maeda J, Ji B, Maruyama M, Okauchi T, Tokunaga M, Ono M, Suhara T
- Journal Title
  
  Biochim Biophys Acta 1802(4)
  
  Pages: 373-388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790047
[Journal Article] Glial cell-mediated deterioration and repair of the nervous system after traumatic brain injury in a rat model as assessed by positron emission tomography2010
- Author(s)
  Yu I, Inaji M, Maeda J, Okauchi T, Nariai T, Ohno K, Higuchi M, Suhara T
- Journal Title
  
  J Neurotrauma
  
  Volume: 27(8) Issue: 8 Pages: 1463-1475
- DOI
  10.1089/neu.2009.1196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590053
[Journal Article] Utility of small-animal positron emission tomographic imaging of rats for preclinical development of drugs acting on the serotonin transporter2009
- Author(s)
  Saijo T, Maeda J, Okauchi T, Maeda JI, Morio Y, Kuwahara Y, Suzuki M, Goto N, Suzuki K, Higuchi M, Suhara T.
- Journal Title
  
  Int J Neuropsychopharmacol 23
  
  Pages: 1-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790047
[Journal Article] Neuroimaging and physiological evidence for involvement of glutamatergic transmission in regulation of the striatal dopaminergic system2009
- Author(s)
  Tokunaga M, Seneca N, Shin RM, Maeda J, Obayashi S, Okauchi T, Nagai Y, Zhang MR, Nakao R, Ito H, Innis RB, Halldin C, Suzuki K, Higuchi M, Suhara T.
- Journal Title
  
  J Neurosci 29(6)
  
  Pages: 1887-1896
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790047
[Journal Article] Quantitative analysis of peripheral benzodiazepine receptor in the human brain using PET with [11C]-AC-5216.2009
- Author(s)
  Miyoshi M, Ito H, Arakawa R, Takahashi H, Takano H, Higuchi M, Okumura M, Otsuka T, Kodaka F, Sekine M, Sasaki T, Fujie S, Seki C, Maeda J, Nakao R, Zhang MR, Fukumura T, Matsumoto M, Suhara T.
- Journal Title
  
  J Nucl Med 50(7)
  
  Pages: 1095-1101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790047
[Journal Article] 遺伝子改変マウスを用いたイメージングバイオマーカーの評価2009
- Author(s)
  前田純、樋口真人、須原哲也
- Journal Title
  
  日本精神神経薬理学雑誌 29巻
  
  Pages: 73-78
- NAID
  10024900097
- Data Source
  KAKENHI-PROJECT-20790047
[Journal Article] 遺伝子改変マウスを用いたイメージングバイオマーカーの評価2009
- Author(s)
  前田純
- Journal Title
  
  日本精神神経薬理学雑誌 29
  
  Pages: 73-78
- NAID
  10024900097
- Data Source
  KAKENHI-PROJECT-20790047
[Journal Article] Development of N-[11C]methylamino 4-hydroxy-2(1H)-quinolone derivatives as PET radioligands for the glycine-binding site of NMDA receptors.2009
- Author(s)
  Fuchigami T, Haradahira T, Fujimoto N, Nojiri Y, Mukai T, Yamamoto F, Okauchi T, Maeda J, Suzuki K, Suhara T, Yamaguchi H, Ogawa M, Magata Y, Maeda M.
- Journal Title
  
  Bioorg Med Chem 17(15)
  
  Pages: 5665-5675
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790047
[Journal Article] Monkey brain activity modulated by reward preferences: a positron emission tomography study.2009
- Author(s)
  Obayashi S, Nagai Y, Suhara T, Okauchi T, Inaji M, Iriki A, Maeda J.
- Journal Title
  
  Neurosci Res 64(4)
  
  Pages: 421-428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790047
[Journal Article] Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies2008
- Author(s)
  Ji B, Maeda J, Sawada M, Ono M, Okauchi T, Inaji M, Zhang MR, Suzuki K, Ando K, Staufenbiel M, Trojanowski JQ, Lee VM, Higuchi M, Suhara T.
- Journal Title
  
  J Neurosci 28(47)
  
  Pages: 12255-12267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790047
[Journal Article] アミロイドイメージングと新しい画像診断法の開発2008
- Author(s)
  前田純
- Journal Title
  
  治療学 42
  
  Pages: 58-62
- Data Source
  KAKENHI-PROJECT-20790047
[Journal Article] Neurobehavioral protection by single dose l-deprenyl against MPTP-induced parkinsonism in common marmosets2008
- Author(s)
  Ando K, Maeda J, Inaji M, Okauchi T, Obayashi S, Higuchi M, Suhara T, Tanioka Y
- Journal Title
  
  Psychopharmacology 195(4)
  
  Pages: 509-516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790047
[Journal Article] Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders2008
- Author(s)
  Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J, Soma M, Takao K, Tanda K, Ohira K, Toyama K, Kanzaki K, Fukunaga K, Sudo Y, Ichinose H, Ikeda M, Iwata N, Ozaki N, Suzuki H, Higuchi M, Suhara T, Yuasa S, Miyakawa T.
- Journal Title
  
  Mol Brain 1(1)
  
  Pages: 6-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790047
[Journal Article] Difference in brain distributions of carbon 11-labeled 4-hydroxy-2(1H)-quinolones as PET radioligands for the glycine-binding site of the NMDA ion channel2008
- Author(s)
  Fuchigami T, Haradahira T, Fujimoto N, Okauchi T, Maeda J, Suzuki K, Suhara T, Yamamoto F, Sasaki S, Mukai T, Yamaguchi H, Ogawa M, Magata Y, Maeda M.
- Journal Title
  
  Nucl Med Biol 35(2)
  
  Pages: 203-212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790047
[Journal Article] Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography2007
- Author(s)
  Maeda J
- Journal Title
  
  Journal of Neuroscience 27(41)
  
  Pages: 10957-10968
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790188
[Journal Article] Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor2007
- Author(s)
  Maeda J
- Journal Title
  
  Brain Research 1157
  
  Pages: 100-111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790188
[Journal Article] 末梢型ベンゾジアゼピン受容体PETリガンドを用いたグリア細胞のイメージング2006
- Author(s)
  前田純
- Journal Title
  
  日本精神神経薬理学雑誌 26(1)
  
  Pages: 33-39
- NAID
  10017327946
- Data Source
  KAKENHI-PROJECT-18790188
[Presentation] Distinct microglial response against Alzheimer’s pathologies characterized by P2Y12 receptor2019
- Author(s)
  Naruhiko Sahara , Jun Maeda , Takeharu Minamihisamatsu , Masafumi Shimojo , Maiko Ono , Keiichiro Minatohara , Hiroyuki Takuwa , Yuhei Takado , Bin Ji , Ming-Rong Zhang , Makoto Higuchi
- Organizer
  Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10387
[Presentation] Microglia engulfment of tangle-bearing neurons in a living tauopathy model2018
- Author(s)
  佐原　成彦, 田桑　弘之, 高堂　裕平, 漆畑　拓弥, 下條　雅文, 高橋　真奈美, 小野　麻衣子, 木村　妙子, 関　千江, 前田　純, 季　斌, 冨田　裕, 張　明栄, 須原　哲也, 樋口　真人
- Organizer
  Society for Neuroscience Annual meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10387
[Presentation] モデルマウスにおけるタウ病態と炎症の経時PETおよび画像病理相関解析2017
- Author(s)
  石川　愛、徳永　正希、田桑　弘之、前田　純、平野　成樹、桑原　聡、須原　哲也、樋口　真人、佐原　成彦
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10387
[Presentation] Visualization of microglial response to tau-induced neurodegeneration in a model of tauopathy2017
- Author(s)
  Naruhiko Sahara , Jun Maeda , Ai Ishikawa , Maiko Ono , Hiroyuki Takuwa , Masafumi Shimojo , Takeharu Minamihisamatsu , Masaki Tokunaga , Shoko Uchida , Izumi Matsumoto , Ming-Rong Zhang , Tetsuya Suhara , Makoto Higuchi
- Organizer
  Alzheimer's Association International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10387
[Presentation] [11C]1-Methyl-L-tryptophanによる脳および膵臓のL-tryptophan利用能の測定2014
- Author(s)
  前田純、熊田勝志、張明栄、徳永正希、南久松丈晴、関千江、樋口真人、須原哲也
- Organizer
  第54回日本核医学会総会
- Place of Presentation
  大阪
- Year and Date
  2014-11-06
- Data Source
  KAKENHI-PROJECT-25460114
[Presentation] PET Imaging of glial activation and neuroinflammation in dementia and other neurological disorders by translocator protein (TSPO) ligands2013
- Author(s)
  Jun Maeda
- Organizer
  Joint Research Projects/Seminars NSFC-JSPS (China-Japan)
- Place of Presentation
  上海
- Invited
- Data Source
  KAKENHI-PROJECT-25460114
[Presentation] Altered serotonin release and serotonin 1A receptor density in CaMKIIα-deficient mice assessed by a comparison of in vivo PET and in vitro autoradiographic data2012
- Author(s)
  Jun Maeda, Masaki Tokunaga, Ming-Rong Zhang, Takeharu Minamihisamatsu, Toshimitsu Fukumura, Tsuyoshi Miyakawa, Tetsuya Suhara, Makoto Higuchi
- Organizer
  Neuroreceptor Mapping 2012
- Place of Presentation
  Baltimore, USA
- Year and Date
  2012-08-08
- Data Source
  KAKENHI-PROJECT-22590053
[Presentation] PET Imaging of glial activation and neuroinflammation in dementia and other neurological disorders by translocator protein (TSPO) ligands2012
- Author(s)
  前田純
- Organizer
  14th Mind Brain Conference
- Place of Presentation
  ホテルクラウンパレス(浜松市)
- Year and Date
  2012-02-15
- Data Source
  KAKENHI-PROJECT-22590053
[Presentation] Altered serotonin release and serotonin 1A receptor density in CaMKII-alpha deficient mice assessed by a comparison of in vivo PET and in vitro autoradiographic data2012
- Author(s)
  Jun Maeda
- Organizer
  Neuroreceptor Mapping 2012
- Place of Presentation
  Baltimore, United States of America
- Data Source
  KAKENHI-PROJECT-22590053
[Presentation] PET Imaging of glial activation and neuroinflammation in dementia and other neurological disorders by translocator protein (TSPO) ligands2012
- Author(s)
  Jun Maeda
- Organizer
  14th Mind Brain Conference
- Place of Presentation
  Hamamatsu
- Year and Date
  2012-02-15
- Data Source
  KAKENHI-PROJECT-22590053
[Presentation] βアミロイド産生マウスを用いたβアミロイドリガンド[^<11>C]PIBの結合機序の解明2011
- Author(s)
  前田純, 他
- Organizer
  生体機能と創薬シンポジウム2011
- Place of Presentation
  東京都渋谷区
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 小動物PETによる認知症モデルマウスのイメージング2011
- Author(s)
  前田純
- Organizer
  第6回分子イメージング学会
- Place of Presentation
  神戸国際会議場(神戸市)
- Year and Date
  2011-05-27
- Data Source
  KAKENHI-PROJECT-22590053
[Presentation] 小動物PETによる認知症モデルマウスのイメージング2011
- Author(s)
  前田純, 他
- Organizer
  第6回日本分子イメージング学会総会・学術集会
- Place of Presentation
  兵庫県神戸市(招待講演)
- Data Source
  KAKENHI-PLANNED-23111009
[Presentation] 小動物PETによる認知症モデルマウスのイメージング2011
- Author(s)
  前田純
- Organizer
  第6回分子イメージング学会
- Place of Presentation
  神戸
- Year and Date
  2011-05-27
- Data Source
  KAKENHI-PROJECT-22590053
[Presentation] 小動物PETを用いたアルツハイマー病診断用PETリガンドの開発とその結合特性の解明2010
- Author(s)
  前田純
- Organizer
  分子イメージング研究シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-01-22
- Data Source
  KAKENHI-PROJECT-20790047
[Presentation] 小動物PETを用いたアルツハイマー病診断用PETリガンドの開発とその結合特性の解明2010
- Author(s)
  前田純
- Organizer
  分子イメージング研究シンポジウム
- Place of Presentation
  日経ホール
- Year and Date
  2010-01-22
- Data Source
  KAKENHI-PROJECT-20790047
[Presentation] In vivo evaluation of a 18kDa translocator protein (TSPO/PBR) ligand [^<11>C]AC-5216 in Alzheimer's disease mouse models2010
- Author(s)
  Maeda J
- Organizer
  World Molecular Imaging Congress 2010
- Place of Presentation
  京都
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-22590053
[Presentation] In vivo evaluation of a 18kDa translocator protein (TSPO/PBR) ligand [11C]AC-5216 in Alzheimer's disease mouse models2010
- Author(s)
  Jun Maeda, Ming-Rong Zhang, Bin Ji, Takashi Okauchi, Toshimitsu Fukumura, Tetsuya Suhara, Makoto Higuchi
- Organizer
  World Molecular Imaging Congress 2010
- Place of Presentation
  Kyoto
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-22590053
[Presentation] 遺伝子改変動物を用いたイメージングバイオマーカーの評価2008
- Author(s)
  前田純
- Organizer
  第18回日本臨床精神神経薬理学会, 第38回日本精神神経薬理学会合同年会
- Place of Presentation
  品川プリンスホテルアネックスタワー
- Year and Date
  2008-10-01
- Data Source
  KAKENHI-PROJECT-20790047
[Presentation] 動物PETを用いたベンゾジアゼピン受容体PETリガンドの開発および評価2008
- Author(s)
  前田純
- Organizer
  第9回日本脳神経核医学研究会
- Place of Presentation
  幕張メッセ
- Year and Date
  2008-10-24
- Data Source
  KAKENHI-PROJECT-20790047
[Presentation] ・-アミロイド産生マウスを用いた・-アミロイドリガンド[11C]PIBの結合機序の解明2008
- Author(s)
  前田純
- Organizer
  生体機能と創薬シンポジウム2008
- Place of Presentation
  東京
- Year and Date
  2008-09-05
- Data Source
  KAKENHI-PROJECT-20790047
[Presentation] 動物定量PETの現状-トランスジェニックマウスとマウス定量PET-2008
- Author(s)
  前田純
- Organizer
  第48回日本核医学会総会
- Place of Presentation
  千葉
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-20790047
[Presentation] 小動物PETを用いた遺伝子改変マウスの分子イメージング2008
- Author(s)
  前田純
- Organizer
  Neuroscience2008
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-20790047
[Presentation] 動物PETを用いたベンゾジアゼピン受容体PETリガンドの開発および評価2008
- Author(s)
  前田純
- Organizer
  第9回日本脳神経核医学研究会
- Place of Presentation
  千葉
- Year and Date
  2008-10-24
- Data Source
  KAKENHI-PROJECT-20790047
[Presentation] 小動物定量PETの現状-トランスジェニックマウスとマウス定量PET-2008
- Author(s)
  前田純
- Organizer
  第48回日本核医学会総会
- Place of Presentation
  幕張メッセ
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-20790047
[Presentation] 東京小動物PETを用いた遺伝子改変マウスの分子イメージング2008
- Author(s)
  前田純
- Organizer
  Neuroscience2008
- Place of Presentation
  東京
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-20790047
[Presentation] β-アミロイド産生マウスを用いたβ-アミロイドリガンド[^<11>C]PIBの結合機序の解明2008
- Author(s)
  前田純
- Organizer
  生体機能と創薬シンポジウム 2008 東京
- Place of Presentation
  星薬科大学
- Year and Date
  2008-09-05
- Data Source
  KAKENHI-PROJECT-20790047
[Presentation] 遺伝子改変動物を用いたイメージングバイオマーカーの評価2008
- Author(s)
  前田純
- Organizer
  第18回日本臨床精神神経薬理学会/第38回日本精神神経薬理学会合同年会
- Place of Presentation
  東京
- Year and Date
  2008-10-01
- Data Source
  KAKENHI-PROJECT-20790047
[Presentation] 末梢性ベンゾジアゼピン受容体PETリガンド[^11C]DAA1106の開発と脳損傷および神経変性による経時変化、グリア特異性について2007
- Author(s)
  前田純
- Organizer
  第2回分子イメージング研究センターシンポジウム
- Place of Presentation
  放射線医学総合研究所
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-18790188
[Presentation] コカインによるドーパミントランスポーター占有率と細胞外ドーパミン濃度の関係性
- Author(s)
  前田　純、関　千絵、南久松丈晴、張　明栄、樋口　真人、須原　哲也
- Organizer
  第24回日本臨床精神神経薬理学会　第44回日本神経精神薬理学会　合同年会
- Place of Presentation
  名古屋
- Year and Date
  2014-11-20 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-25460114

1. HIGUCHI Makoto (10373359)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. INAJI Motoki (00422486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. SATO Katsushige (80291342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SUHARA Tetsuya (90216490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. YOSHIYAMA Yasumasa (50292701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAKUWA Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. JI Bin

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. TAKAO Keizo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. KOREKANE Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 破入正行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 鈴木匡子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 鈴木道雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 小林和人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 宮川剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 高尾昌樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 森寿

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 高尾英正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 青木茂樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 中村克樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 饗場篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 谷口直之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Maeda Jun 前田 純

MAEDA Jun 前田 純

Research Projects

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Co-Researchers

Imaging of microglial functions by P2X7 and P2Y12 receptor PET ligandsPrincipal Investigator

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Elucidation for a role of kynurenine pathway on the pathogenesis of depressionPrincipal Investigator

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In vivo PET and optical imaging of neurogenesis of neuronal circuit

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Molecular imaging of neurotoxic signaling in neurodegenerative disorders

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Functional bioimaging of brain microglia by purine receptor PET ligandsPrincipal Investigator

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In vivo activated glia imaging by development of novel peripheral benzodiazepine receptor ligandsPrincipal Investigator

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神経変性過程における末梢性ベンゾジアゼピン受容体機能の解明Principal Investigator

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[Book] 臨床精神薬理 第20巻9号〈特集〉向精神薬の多剤規制と減量・離脱の実際2017

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[Book] 専門医のための精神科臨床リュミエール26依存性・衝動制御障害の治療2011

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[Book] 認知症モデルマウスのイメージング,PET journal No.152011

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[Book] 物質依存の神経画像-PETを用いた研究,専門医のための精神科臨床リュミエール 26巻 依存症・衝動制御障害の治療2011

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[Journal Article] Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model.2020

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[Journal Article] In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg45102018

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[Journal Article] Microglial Activation During Pathogenesis of Tauopathy in rTg4510 Mice: Implications for the Early Diagnosis of Tauopathy.2018

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Maeda Jun 前田純

MAEDA Jun 前田純

[Book] 臨床精神薬理　第20巻9号〈特集〉向精神薬の多剤規制と減量・離脱の実際2017

[Book] 物質依存の神経画像-PETを用いた研究,専門医のための精神科臨床リュミエール 26巻依存症・衝動制御障害の治療2011