Kowata Shugo 古和田周吾

… Alternative Names

KOWATA Syugo 古和田周吾

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Researcher Number	30418884
Affiliation (Current)	2023: 岩手医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2019 – 2022: 岩手医科大学, 医学部, 講師 2015 – 2017: 岩手医科大学, 医学部, 講師 2015: 岩手医科大学, 医学部内科学講座血液腫瘍内科分野, 教授 2013 – 2014: 岩手医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology Except Principal Investigator Hematology
Keywords	Principal Investigator 巨核球 / 血小板 / 血小板産生 / Autophagy / 肺 / 骨髄 / platelet production / mitchondria / thrombopoiesis / proplatelet … More / PDL-1 / JAK2遺伝子変異 / autophagy / 特発性血小板減少性紫斑病 / 血小板減少症 / miRNA / 細胞内小器官 / microRNA / 新生血小板 … More Except Principal Investigator 成熟血小板 / 血小板前駆体 / 巨核球 / 血小板造血 / preplatelet / 血小板産生 / immature platelet / thick protrusion / proplatelet / thrombocytopoiesis / megakaryocyte Less

Platelet heterogeneity depending on the site of platelet production from megakaryocytePrincipal Investigator
- Principal Investigator
  
  古和田周吾
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Iwate Medical University
regulation of autophagy flux in megakaryocyte-platelet lineagePrincipal Investigator
- Principal Investigator
  
  Kowata Shugo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Iwate Medical University
microRNA in nascent plateletPrincipal Investigator
- Principal Investigator
  
  Kowata Shugo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Iwate Medical University
Where and how are mature platelets produced?
- Principal Investigator
  
  Ishida Yoji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Iwate Medical University

All 2021 2020 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] Megakaryopoiesis and thrombopoiesis.2017
- Author(s)
  Shugo Kowata, Yoji Ishida
- Total Pages
  500
- Publisher
  Springer Science
- Data Source
  KAKENHI-PROJECT-15K09458
[Book] Autoimmune thrombocytopenia（分担執筆：Splenectomy)2017
- Author(s)
  Shugo Kowata, Yoji Ishida
- Total Pages
  229
- Publisher
  Springer Science Business Media Singapore Pte Ltd.
- ISBN
  9789811041419
- Data Source
  KAKENHI-PROJECT-15K09458
[Book] Autoimmune thrombocytopenia（分担執筆：Megakaryopoiesis and thrombopoiesis）2017
- Author(s)
  Shugo Kowata, Yoji Ishida
- Total Pages
  229
- Publisher
  Springer Science Business Media Singapore Pte Ltd.
- ISBN
  9789811041419
- Data Source
  KAKENHI-PROJECT-15K09458
[Journal Article] Treatment of secondary engraftment failure with granulocyte colony-stimulating factor and eltrombopag after allogeneic peripheral blood stem cell transplantation in adult T-cell leukemia/lymphoma2021
- Author(s)
  清原千貴，菅原教史，前田峻大，宮島真理，高野幹，西谷匡央，西谷真来，佐々木了政，岡野良昭，上原さつき，古和田周吾，小宅達郎，伊藤薫樹
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 62 Issue: 10 Pages: 1499-1504
- DOI
  10.11406/rinketsu.62.1499
- NAID
  130008113175
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08873
[Journal Article] Acute Liver Injury Due to T-cell Infiltration into the Liver as an Initial Clinical Finding of Adult T-cell Leukemia/Lymphoma2021
- Author(s)
  Keisuke,Kakisaka.,Yuji,Suzuki.,Shugo,Kowata.,Shigeki,Ito.,Yasuhiro,Takikawa.
- Journal Title
  
  Intern. Med.
  
  Volume: 60 Issue: 15 Pages: 2431-2436
- DOI
  10.2169/internalmedicine.6793-20
- NAID
  130008070621
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2021-08-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08873
[Journal Article] JAK2V617 変異を伴う骨髄増殖性腫瘍の変異クローンの拡大はPD-1陽性CD８陽性細胞の減少を伴う2021
- Author(s)
  宮島真理、古和田周吾、
- Journal Title
  
  岩手医学雑誌
  
  Volume: 73
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08873
[Journal Article] Treatment-free remission after ffirst-line dasatinib discontinuation in patients with chronic myeloid leukaemia2020
- Author(s)
  Kimura S, Imagawa J, Murai K, Hino M, Kitawaki T, Okada M, Tanaka H, Shindo M,　Kumagai T, Ikezoe T, Uoshima N, Sato T, Watanabe R, Kowata S, Hayakawa M, Hosoki T, Ikeda K
- Journal Title
  
  Lancet Haematol.
  
  Volume: 7 Pages: 218-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08873
[Journal Article] Doripenem versus meropenem as first-line empiric therapy of febrile neutropenia in patients with acute leukemia: a prospective, randomized study.2020
- Author(s)
  Oyake T, Takemasa-Fujisawa Y, Sugawara N, Mine T, Tsukushi Y, Hanamura I, Fujishima Y, Aoki Y, Kowata S, Ito S, Ishida Y.：
- Journal Title
  
  Ann. Hematol
  
  Volume: 98 Pages: 1209-1216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08873
[Journal Article] Autophagosome　rich platelet2020
- Author(s)
  Akihiro　Otsu, Kowata Shugo, Yuki Seki, et.al
- Journal Title
  
  Iwate Medical Journal
  
  Volume: 67 Pages: 225230-225230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08873
[Journal Article] Autophagosome-rich Platelets are increased in immune thrombocytopenia.2020
- Author(s)
  Akihiro,Otsu.,Shugo,Kowata.,Yuki,Seki.,Kazunori,Murai.,Kazuki,Kiyohara.,Shinri,Miyajima.,Wataru,Izumita.,Jiro,Hitomi.,Yoji,Ishida.,Shigeki,Ito.
- Journal Title
  
  Journal of Iwate Medical Association
  
  Volume: 72 Pages: 103-113
- NAID
  130007898058
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08873
[Journal Article] 血小板放出後の成熟2017
- Author(s)
  古和田周吾　大津瑛裕
- Journal Title
  
  血液フロンテイア
  
  Volume: 27（６） Pages: 839-844
- Data Source
  KAKENHI-PROJECT-15K09458
[Journal Article] マウスを用いた血小板造血の評価方法の検討2017
- Author(s)
  外川　亮　　古和田周吾
- Journal Title
  
  岩手医学誌
  
  Volume: 10 Pages: 251-251
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09458
[Journal Article] 末梢血液による血小板造血の評価：マウスを用いた基礎的研究2017
- Author(s)
  外川亮　古和田周吾
- Journal Title
  
  岩手医学雑誌
  
  Volume: Vol69(4) Pages: 209-216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09458
[Journal Article] Comparison of micafangin and voriconazole as emperic therapies in febrile neutropenia in patients with hematological disorders: a randomized controlled trial.2016
- Author(s)
  Oyake T, Kowata S, Murai K, Ito S, Akagi T, Kubo K, Sawada K, Ishida Y.
- Journal Title
  
  Eur J Haematol
  
  Volume: 96 Issue: 6 Pages: 602-609
- DOI
  10.1111/ejh.12641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09458, KAKENHI-PROJECT-25461458
[Journal Article] マウス全血中の血小板前駆体の解明2015
- Author(s)
  下山格　古和田周吾
- Journal Title
  
  岩手医学雑誌
  
  Volume: 67 Pages: 225-232
- NAID
  40020698465
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09458
[Journal Article] Platelet demand modulates the type of intravascular protrusion of megakaryocytes in bone marrow2014
- Author(s)
  Shugo Kowata, Sumio Isogai, Kazunori Murai, Shigeki Ito, Koujiro Tohyama, Masatsugu Ema, Jiro Hitomi, and Yoji Ishida
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: ?
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461458
[Journal Article] Bortezomib induces thrombocytopenia by the inhibition of proplatelet formation of megakaryocytes2014
- Author(s)
  Kazunori Murai, Shugo Kowata, Tadashi Shimoyama, Akiko Yashima-Abo, Yukiteru Fujishima, Shigeki Ito, and Yoji Ishida
- Journal Title
  
  Eur J Haematol
  
  Volume: ? Issue: 4 Pages: 290-296
- DOI
  10.1111/ejh.12342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461458
[Journal Article] Platelet demand modulates the type of intravascular protrusion of megakaryocytes in bone marrow2014
- Author(s)
  Kowata S, Isogai S, Murai K, Ito S, Tohyama K, Ema M, Hitomi J and Ishida Y
- Journal Title
  
  Thrombosis and Haemostasis
  
  Volume: 112 Issue: 10 Pages: 743-756
- DOI
  10.1160/th14-02-0123
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] PD-1 positive CD8+T-cells and allele burden in JAK2V617 positive MPNs2021
- Author(s)
  宮島真理、古和田周吾、岡野良昭、小宅達郎、伊藤薫樹
- Organizer
  第83回日本血液学会総会
- Data Source
  KAKENHI-PROJECT-19K08873
[Presentation] Usefulness of presepsin as a diagnostic biomarker of HPS associated with hematological disease2021
- Author(s)
  岡野良昭，小宅達郎，浅野雄哉，佐藤剛，清原千貴，西谷真来，菅原教史，佐々木了政，古和田周吾，伊藤薫樹
- Organizer
  第83回日本血液学会総会
- Data Source
  KAKENHI-PROJECT-19K08873
[Presentation] ドナーリンパ球輸注が奏効した血縁者間同種造血幹細胞移植後の播種性アデノウイルス感染症の一例2021
- Author(s)
  宮島真理，菅原教史，浅野雄哉，前田峻大，清原千貴，高野幹，西谷真来，佐々木了政，岡野良昭，古和田周吾，小宅達郎，伊藤薫樹
- Organizer
  第83回日本血液学会総会
- Data Source
  KAKENHI-PROJECT-19K08873
[Presentation] Retrospective analysis of ICI therapy for r/r classical lymphoma:THP262021
- Author(s)
  前田峻大、岡野良昭、古和田周吾、小宅達郎、伊藤薫樹
- Organizer
  第83回日本血液学会総会
- Data Source
  KAKENHI-PROJECT-19K08873
[Presentation] Stauprimide induces mitotic cell cycle arrest and apoptosis in multiple myeloma2021
- Author(s)
  清原千貴，西谷真来，菅原教史，佐々木了政，古和田周吾，伊藤薫樹
- Organizer
  第83回日本血液学会総会
- Data Source
  KAKENHI-PROJECT-19K08873
[Presentation] Autophagosome　rich platelets are increased in patients with ITP2020
- Author(s)
  Akihiro Otsu, Shugo Kowata, Yuki Seki, et.al
- Organizer
  Europian Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08873
[Presentation] Autophagosome-rich platelets are increased in patients with immune thrombocytopenia.2020
- Author(s)
  Akihiro Otsu, Shugo Kowata，Yuki Seki，Kazunori Murai, Kazuki Kiyohara, Shinri Miyajima, Wataru Izumita, Jiro Hitomi, Yoji Ishida, Shigeki Ito.
- Organizer
  25st European Hematology Association (EHA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08873
[Presentation] 血小板減少症の末梢血を用いた鑑別方法の検討2017
- Author(s)
  近藤有佳、浅野雄哉、伊藤豪仁、古和田周吾、外川亮、小宅達郎、石田陽治
- Organizer
  第114回日本内科学会総会医学生研修医の日本内科学会ことはじめ
- Data Source
  KAKENHI-PROJECT-15K09458
[Presentation] 会長招請シンポジウム　血小板放出後の成熟2017
- Author(s)
  古和田周吾
- Organizer
  第39回日本血栓止血学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09458
[Presentation] 新生血小板におけるAutophagy2017
- Author(s)
  古和田周吾　村井一範、伊藤薫樹、守屋雄太、石田陽治
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09458
[Presentation] Dynamics of platelet progenitors in mice and humen.2016
- Author(s)
  Shugo Kowata
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K09458
[Presentation] ITPの基礎と臨床2016
- Author(s)
  古和田　周吾
- Organizer
  Novartis Hematology Seminor
- Place of Presentation
  沖縄県宜野湾市
- Year and Date
  2016-04-22
- Invited
- Data Source
  KAKENHI-PROJECT-15K09458
[Presentation] 巨核球からの血小板産生過程のイメージング2016
- Author(s)
  古和田　周吾
- Organizer
  第64回日本輸血・細胞治療学会総会
- Place of Presentation
  京都
- Year and Date
  2016-04-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K09458
[Presentation] 巨核球からの血小板産生過程のイメージング2016
- Author(s)
  古和田　周吾
- Organizer
  日本輸血細胞治療学会総会
- Place of Presentation
  京都市
- Year and Date
  2016-04-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K09458
[Presentation] Platelet progenitors after leaving bone marrow.2015
- Author(s)
  古和田周吾　磯貝純夫　村井一範　伊藤薫樹　人見次郎　石田陽治
- Organizer
  日本血液学会総会
- Place of Presentation
  金沢市
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K09458
[Presentation] Doripenemu versus meropenem as the first-line mono-therapy in high risk febrile neutropenic patients with acute leukemia : A randomized, controlled study2015
- Author(s)
  Sugawara N, Oyake T, Fujisawa Y, Sasaki R, Mine T, Tsukushi Y, Hanamura I, Asahi M, Suzuki Y, Okano Y, Fijishima Y, Aoki Y, Kowata S, Ito S, Ishida Y
- Organizer
  20th Congress of the European Hematology Association
- Place of Presentation
  Vienna, Austria
- Year and Date
  2015-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] Platelet progenitors after leaving bone marrow2015
- Author(s)
  Shugo Kowata, S.Isogai, K. Murai, S. Ito, J. Hitomi, Y. Ishida,
- Organizer
  20th Congress of the European Hematology Association
- Place of Presentation
  Vienna, Austria
- Year and Date
  2015-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09458
[Presentation] Platelet Progenitors after Leaving Bone Marrow2015
- Author(s)
  Shugo Kowata, Ryo Togawa, Yoshiaki Okano, Sumio Isogai, Jiro Hitomi, Kazunori Murai, Shigeki Ito, Yoji Ishida,
- Organizer
  57th Annual Meeting of America Society of Hematology
- Place of Presentation
  Orland, FL, USA
- Year and Date
  2015-12-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] Comparison of micafungin and liposome amphotericin B for empirical anti fungal therapy in febrile neutropenic patients with hematological malignancies: A randomized controlled study2015
- Author(s)
  Fujisawa Y, Oyake T, Sugawara N, Sasaki R, Tsukushi Y, Hanamura I, Fujishima Y, Aoki Y, Kowata S, Ito S, Ishida Y
- Organizer
  20th Congress of the European Hematology Association
- Place of Presentation
  Vienna, Austria
- Year and Date
  2015-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] Platelet Progenitors after Leaving Bone Marrow2015
- Author(s)
  Kowata S, Murai K, Oyake T, Ito S, Ishida Y
- Organizer
  20th Congress of the European Hematology Association
- Place of Presentation
  Vienna, Austria
- Year and Date
  2015-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] Platelet progenitors after leaving bone marrow2015
- Author(s)
  Shugo Kowata, S.Isogai, K. Murai, S. Ito, J. Hitomi, Y. Ishida,
- Organizer
  57th Annual meeting of American Society of Hematology
- Place of Presentation
  Orland, FL, USA
- Year and Date
  2015-12-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09458
[Presentation] Dasatinib Induced Thrombocytopenia Might Be Due To The Inhibition Of Proplatelet Formation Of Megakaryocytes Via The Pathways Including Rho/Rock and Rac2013
- Author(s)
  Kazunori Murai, Shugo Kowata, Yukiteru Fujishima, Yasuhiko Tsukushi, Takahiro Mine, Tatsuo Oyake, Shigeki Ito, and Yoji Ishida
- Organizer
  55th ASH annual Meeting and Exposition
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] PLATELET PROGENITORS AFTER LEAVING BONE MARROW
- Author(s)
  Kowata S, Murai K, Oyake T, Ito S, Ishida Y
- Organizer
  the 20th Congress of the European Hematology Association
- Place of Presentation
  Vienna
- Year and Date
  2015-06-11 – 2015-06-14
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] Dasatinib Is Effective in theTreatment of Mice Models with Immune Thrombocytopenia
- Author(s)
  Shimoyama T, Okano Y, Fujishima Y, Oyake T,Kowata S, Murai K, Ito S, and Ishida Y
- Organizer
  56th American Society of Hematology Meeting and Exoosition
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-12-05 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] COMPARISON OF MICAFUNGIN AND LIPOSOMAL AMPHOTERICIN B FOR EMPIRICAL ANTIFUNGAL THERAPY IN FEBRILE NEUTROPENIC PATIENTS WITH HEMATOLOGICAL MALIGNANCIES: A RANDOMIZED CONTROLLED TRIAL
- Author(s)
  Fujisawa Y, Tatsuo Oyake T, Sugawara N, Sasaki R, Tsukushi Y, Hanamura I, Fujishima Y, Aoki Y, Kowata1 S, Ito S, Ishida Y
- Organizer
  the 20th Congress of the European Hematology Association
- Place of Presentation
  Vienna, Austria
- Year and Date
  2015-06-11 – 2015-06-14
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] ndex to Predict MMR at 12 Months in Chronic Phase Chronic Myeloid Leukemia Patients Based on the Area Under the Lymphocyte Curve
- Author(s)
  Murai K, Ito S, Kowata S, Oyake T and Ishida Y,
- Organizer
  56th American Society of Hematology Meeting and Exoosition
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-12-05 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-25461458
[Presentation] DORIPENEM VERSUS MEROPENEM AS THE FIRST-LINE MONO-THERAPY IN HIGH-RISK FEBRILE NEUTROPENIC PATIENTS WITH ACUTE LEUKEMIA: A RANDOMIZED, CONTROLLED TRIAL
- Author(s)
  Sugawara N, Oyake T, Fujisawa Y, Sasaki R, Mine T, Tsukushi Y, Hanamura I, Asahi M, Suzuki Y, Okano Y, Fujishima Y, Aoki Y, Kowata S, Ito S, Ishida Y
- Organizer
  the 20th Congress of the European Hematology Association
- Place of Presentation
  Vienna, Austria
- Year and Date
  2015-06-11 – 2015-06-14
- Data Source
  KAKENHI-PROJECT-25461458

1. Ishida Yoji (70151389)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
2. ITO Shigeki (60316362)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
3. 佐々木了政 (40825501)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 岡野良昭 (60871720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 阿保亜紀子 (80326686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kowata Shugo 古和田 周吾

KOWATA Syugo 古和田 周吾

Research Projects

Research Products

Co-Researchers

Platelet heterogeneity depending on the site of platelet production from megakaryocytePrincipal Investigator

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regulation of autophagy flux in megakaryocyte-platelet lineagePrincipal Investigator

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microRNA in nascent plateletPrincipal Investigator

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Where and how are mature platelets produced?

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[Book] Megakaryopoiesis and thrombopoiesis.2017

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[Book] Autoimmune thrombocytopenia（分担執筆：Splenectomy)2017

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[Book] Autoimmune thrombocytopenia（分担執筆：Megakaryopoiesis and thrombopoiesis）2017

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[Journal Article] Treatment of secondary engraftment failure with granulocyte colony-stimulating factor and eltrombopag after allogeneic peripheral blood stem cell transplantation in adult T-cell leukemia/lymphoma2021

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[Journal Article] Acute Liver Injury Due to T-cell Infiltration into the Liver as an Initial Clinical Finding of Adult T-cell Leukemia/Lymphoma2021

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[Journal Article] JAK2V617 変異を伴う骨髄増殖性腫瘍の変異クローンの拡大はPD-1陽性CD８陽性細胞の減少を伴う2021

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[Journal Article] Treatment-free remission after ffirst-line dasatinib discontinuation in patients with chronic myeloid leukaemia2020

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[Journal Article] Doripenem versus meropenem as first-line empiric therapy of febrile neutropenia in patients with acute leukemia: a prospective, randomized study.2020

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[Journal Article] Autophagosome rich platelet2020

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[Journal Article] Autophagosome-rich Platelets are increased in immune thrombocytopenia.2020

Kowata Shugo 古和田周吾

KOWATA Syugo 古和田周吾

[Journal Article] Autophagosome　rich platelet2020

[Presentation] Autophagosome　rich platelets are increased in patients with ITP2020