Hiroi Miki 廣井美紀

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HIROI Miki 廣井美紀

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Researcher Number	30419717
Other IDs
Affiliation (Current)	2025: 明海大学, 歯学部, 准教授
Affiliation (based on the past Project Information) *help	2025: 明海大学, 歯学部, 准教授 2022 – 2023: 明海大学, 歯学部, 准教授 2014 – 2022: 明海大学, 歯学部, 講師 2007 – 2014: Meikai University, 歯学部, 助教 2006: 明海大学, 歯学部, 助手
Review Section/Research Field	Principal Investigator Functional basic dentistry / Basic Section 57060:Surgical dentistry-related / Pathobiological dentistry/Dental radiology / Morphological basic dentistry Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Pathobiological dentistry/Dental radiology / Basic Section 57020:Oral pathobiological science-related / Functional basic dentistry
Keywords	Principal Investigator インターフェロン / 低酸素 / ケモカイン / CXCL10 / CXCL9 / シグナル伝達 / 転写 / M２マクロファージ / M1マクロファージ / 腫瘍 … More / マクロファージ / 口腔癌 / 腫瘍関連マクロファージ / 遺伝子制御 … More Except Principal Investigator 口腔癌 / CXCL10 / インターフェロン / ケモカイン / 遺伝子発現 / 口腔扁平上皮癌 / CD163 / マクロファージ / Sunitinib / CCL2 / 骨髄由来抑制細胞 ( MDSC) / 口腔潜在的悪性疾患（OPMDs） / LY-6G(Gr-1+cells) / Cxcl5(ENA-78) / Cxcl3(Gro-α) / Ccl4(Mip-β) / Ccl3(Mip-1α) / MDSC / OPMDs / IFN誘導性ケモカイン / T細胞 / IFN誘導生ケモカイン / DPP4 / 腫瘍免疫 / ヒストン脱アセチル化酵素阻害剤 / ヒストンメチル期転移酵素阻害剤 / HDAC阻害剤 / メチル化阻害剤 / 細胞増殖 / エピゲノム / メチル化 / 口腔癌細胞 / インターフェロン耐性 / 前癌病変 / 扁平上皮癌 / IFN / Perforin / CD31 / CXC11 / F4/80 / CD8 / CD4 / CXCL11 / NF-κB / Mediator / NF-kB / CXCL9 / STAT1 / CDK8 / メディエーター複合体 / 転写制御 / 低酸素 / IL-13 / 抗炎症 / 免疫組織 / IL-4 / STAT6 / Il-4 / 腫瘍 / M2マクロファージ / シグナル伝達 Less

口腔癌形成におけるTREM2の役割を探るPrincipal Investigator
- Principal Investigator
  
  廣井美紀
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Meikai University
口腔癌発症における骨髄由来免疫抑制細胞(MDSC)による腫瘍免疫抑制作用の検討
- Principal Investigator
  
  森一将
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Meikai University
Inactivation of IFN-induced chemokines by DPP4 and its clinical significance in oral cancer
- Principal Investigator
  
  MORI Kazumasa
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Meikai University
Elucidation of the mechanisms of interferon resistance in oral cancer and the efficacy of combined immuno-epigenomic therapy
- Principal Investigator
  
  Yoshihiro Ohmori
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Meikai University
Culture induction mechanism of tumor-associated macrophage and functionals analysis in precancerous lesions and squamous cell carcinoma
- Principal Investigator
  
  MORI Kazumasa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Meikai University
The mechanism of development of tumor-associated macrophage in oral squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  HIROI Miki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Meikai University
The role of the Mediator complexes in transcriptional regulation of the chemokine genes
- Principal Investigator
  
  Ohmori Yoshihiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Meikai University
Analysis of the inhibitory mechanisms of IFN gamma induced gene expression by hypoxiaPrincipal Investigator
- Principal Investigator
  
  HIROI Miki
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Meikai University
Regulatory mechanisms of gene expression in anti-inflammatory M2 macrophages
- Principal Investigator
  
  OHMORI Yoshihiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Meikai University
Transcriptional repression of interferon-gamma-inducible gene by hypoxiaPrincipal Investigator
- Principal Investigator
  
  HIROI Miki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Meikai University
低酸素によるインターフェロン・ガンマー誘導性遺伝子発現の抑制機構の解析Principal Investigator
- Principal Investigator
  
  廣井美紀
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University

All 2022 2021 2020 2015 2011 2010 2009 2007 Other

All Journal Article Presentation

[Journal Article] Enhanced Cytotoxic Effects in Human Oral Squamous Cell Carcinoma Cells Treated with Combined Methyltransferase Inhibitors and Histone Deacetylase Inhibitors2022
- Author(s)
  Ryosuke Ushio, Miki Hiroi, Ari Matsumoto, Kazumasa Mori, Nobuharu Yamamoto, Yoshihiro Ohmori
- Journal Title
  
  Biomedicines
  
  Volume: 10 Issue: 4 Pages: 763-763
- DOI
  10.3390/biomedicines10040763
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10076, KAKENHI-PROJECT-20K10102
[Journal Article] Simultaneous Expression of Th1- and Treg-Associated2021
- Author(s)
  Hana Yamaguchi, Miki Hiroi, Kazumasa Mori et al
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 8 Pages: 1835-1835
- DOI
  10.3390/cancers13081835
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10102
[Journal Article] Infiltration of M2 tumor-associated macrophages in oral squamous cell carcinoma correlates with tumor malignancy2011
- Author(s)
  K. Mori, M. Hiroi, J. Shimada and Y. Ohmori
- Journal Title
  
  Cancers
  
  Volume: 3 Issue: 4 Pages: 3726-3739
- DOI
  10.3390/cancers3043726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592371, KAKENHI-PROJECT-22592244
[Presentation] IFN誘導性ケモカインCXCL9、CXCL10、CXCL11のマウス扁平上皮癌細胞に対する抗腫瘍作用の違い2022
- Author(s)
  松本安吏, 森一将, 廣井美紀, 嶋田淳, 山本信治, 大森喜弘
- Organizer
  第76回 NPO法人日本口腔科学会学術集会
- Data Source
  KAKENHI-PROJECT-20K10102
[Presentation] 口腔癌におけるMyeloid-derived suppressor cellとケモカインの影響についての検討2022
- Author(s)
  森　一将　松本安吏　廣井美紀　山本信治　大森喜弘
- Organizer
  第67回公益社団法人日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-20K10102
[Presentation] 口腔癌における腫瘍関連マクロファージの分化誘導に関わる浸潤T細胞の検討2021
- Author(s)
  森　一将　松本安吏　廣井美紀　山本信治　大森喜弘
- Organizer
  日本口腔外科学会
- Data Source
  KAKENHI-PROJECT-20K10102
[Presentation] 口腔扁平上皮癌細胞に対するDNAメチル化転移酵素阻害剤とヒストン脱アセチル化酵素阻害剤の併用処理による細胞傷害作用2021
- Author(s)
  牛尾亮介、廣井美紀、松本安吏、森　一将、大森喜弘
- Organizer
  第63回歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-19K10076
[Presentation] インターフェロン誘導性ケモカインCXCL9, CXCL10, CXCL11のマウス扁平上皮癌細胞に対する抗腫瘍作用の違い2021
- Author(s)
  松本安吏、森　一将、廣井美紀、大森喜弘
- Organizer
  第63回歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-19K10076
[Presentation] Differential antitumor effects of IFN-inducible chemokines CXCL9, CXCL10 and CXCL11 on mouse squamous cell carcinoma2021
- Author(s)
  Ari MATSUMOTO, Kazumasa MORI, Miki HIROI, Yoshihiro OHMORI
- Organizer
  Japanese Association for Oral Biology
- Data Source
  KAKENHI-PROJECT-20K10102
[Presentation] Investigation of chemokines involved in the infiltration of myeloid-derived suppressor cells (MDSCs) in the mouse tongue cancer model2021
- Author(s)
  Kazumasa MORI, Miki HIROI, Ari MATSUMOTO, Ryousuke USHIO, Yoshihiro OHMORI
- Organizer
  Japanese Association for Oral Biology
- Data Source
  KAKENHI-PROJECT-20K10102
[Presentation] マウス舌癌モデルにおけるMyeloid-derived suppressor cells (MDSCs)の浸潤に関わるケモカインの検討2021
- Author(s)
  森　一将、廣井美紀、松本安吏、牛尾亮介、大森喜弘
- Organizer
  第63回歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-19K10076
[Presentation] メチル化阻害剤によるIFN耐性ヒト口腔扁平上皮癌細胞に対する細胞増殖抑制作用2020
- Author(s)
  牛尾亮介、廣井美紀、松本安吏、森一将、嶋田淳、山本信治、大森喜弘
- Organizer
  第65回口腔外科学会　総会
- Data Source
  KAKENHI-PROJECT-19K10076
[Presentation] メチル化阻害剤による口腔扁平上皮癌細胞の増殖抑制作用2020
- Author(s)
  牛尾亮介、廣井美紀、嶋田　淳、山本信治、大森喜弘
- Organizer
  第62回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19K10076
[Presentation] 口腔前癌病変におけるCD163+腫瘍関連マクロファージの分化誘導への浸潤ヘルパー1型T細胞の関与2015
- Author(s)
  森一将、廣井美紀、嶋田淳、大森喜弘
- Organizer
  第57回歯科基礎医学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟県新潟市）
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-26462855
[Presentation] 抗炎症性M2マクロファージにおけるArg-1遺伝子発現制御機構2011
- Author(s)
  廣井美紀、大森喜弘
- Organizer
  第53回日本歯科基礎医学会総会
- Place of Presentation
  岐阜、長良川国際会議場
- Year and Date
  2011-10-02
- Data Source
  KAKENHI-PROJECT-21592371
[Presentation] 抗炎症性M2マクロファージにおけるArg-1遺伝子発現制御機構2011
- Author(s)
  廣井美紀, 大森喜弘
- Organizer
  歯科基礎医学会
- Place of Presentation
  岐阜
- Year and Date
  2011-10-02
- Data Source
  KAKENHI-PROJECT-21592371
[Presentation] 低酸素はIFNγ誘導性ケモカインCXCL9/Mig,CXCL10/IP-10 の発現を抑制する2010
- Author(s)
  廣井美紀, 大森喜弘
- Organizer
  第52回歯科基礎医学会学術大会・総会
- Place of Presentation
  東京都
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22791797
[Presentation] 低酸素はIFNγ誘導性ケモカインCXCL9/Mig、CXCL10/IP-10の発現を抑制する2010
- Author(s)
  廣井美紀、大森喜弘
- Organizer
  第52回歯科基礎医学会学術大会・総会
- Place of Presentation
  タワーホール船堀(東京都)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22791797
[Presentation] 低酸素による抗炎症性M2マクロファージの遺伝子発現制御2009
- Author(s)
  廣井美紀
- Organizer
  第51回歯科基礎医学会
- Place of Presentation
  朱鷺メッセ新潟コンベンションセンター(新潟)
- Year and Date
  2009-09-11
- Data Source
  KAKENHI-PROJECT-21592371
[Presentation] HYPOXIA INHIBITS INTERFERON GAMMA-INDUCED GENE EXPRESSION VIADOWN-REGULATION OF Ser727 STATI PHOSPHORYLATION IN HUMAN TUMOR CELL LINES2007
- Author(s)
  廣井美紀
- Organizer
  International Society for Interferon and Cytokine Research
- Place of Presentation
  Oxford, UK
- Year and Date
  2007-09-16
- Data Source
  KAKENHI-PROJECT-18791356
[Presentation] ケモカイン遺伝子のメディエーター複合体による転写制御
- Author(s)
  廣井美紀、大森喜弘
- Organizer
  第56回歯科基礎医学会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25462928

1. OHMORI Yoshihiro (50194311)

# of Collaborated Projects: 5 results

# of Collaborated Products: 16 results
2. MORI Kazumasa (80372902)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
3. SEKINE Keisuke (00323569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 小貫裕之 (50598258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 松本安吏 (80965129)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hiroi Miki 廣井 美紀

HIROI Miki 廣井 美紀

Research Projects

Research Products

Co-Researchers

口腔癌形成におけるTREM2の役割を探るPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

口腔癌発症における骨髄由来免疫抑制細胞(MDSC)による腫瘍免疫抑制作用の検討

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Inactivation of IFN-induced chemokines by DPP4 and its clinical significance in oral cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanisms of interferon resistance in oral cancer and the efficacy of combined immuno-epigenomic therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Culture induction mechanism of tumor-associated macrophage and functionals analysis in precancerous lesions and squamous cell carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism of development of tumor-associated macrophage in oral squamous cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of the Mediator complexes in transcriptional regulation of the chemokine genes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the inhibitory mechanisms of IFN gamma induced gene expression by hypoxiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulatory mechanisms of gene expression in anti-inflammatory M2 macrophages

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transcriptional repression of interferon-gamma-inducible gene by hypoxiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

低酸素によるインターフェロン・ガンマー誘導性遺伝子発現の抑制機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Enhanced Cytotoxic Effects in Human Oral Squamous Cell Carcinoma Cells Treated with Combined Methyltransferase Inhibitors and Histone Deacetylase Inhibitors2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simultaneous Expression of Th1- and Treg-Associated2021

Author(s)

Journal Title

DOI

Hiroi Miki 廣井美紀

HIROI Miki 廣井美紀