Watanabe Hirotaka 渡部博貴

Researcher Number	30422413
Other IDs
Affiliation (Current)	2025: 藤田医科大学, 精神・神経病態解明センター, 客員講師
Affiliation (based on the past Project Information) *help	2024: 慶應義塾大学, 殿町先端研究教育連携スクエア, 特任講師 2021 – 2023: 慶應義塾大学, 医学部(信濃町), 特任講師 2016 – 2019: 慶應義塾大学, 医学部(信濃町), 特任講師 2015: 慶應義塾大学, 医学部, 特任講師
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Transformative Research Areas, Section (III) / Pathological medical chemistry / Neurophysiology / General neuroscience Except Principal Investigator Basic Section 52020:Neurology-related
Keywords	Principal Investigator アルツハイマー病 / プレセニリン / シナプス / iPS細胞 / 神経科学 / 近接依存性標識法 / シナプス機能 / APOE / ミクログリア / 神経疾患 / モデルマウス / 神経変性疾患 / シングルセル … More Except Principal Investigator … More ミクログリア / ロピニロール / ヒトiPSC / 筋萎縮性側索硬化症 / トランスクリプトーム / アストログリア / アストロサイト / プロテオーム解析 / 体液由来細胞外小胞 / ロピニロール塩酸塩 / グリア細胞 / 脊髄運動ニューロン / ヒトiPS細胞 Less

ALS運動ニューロン標的iPS細胞創薬から同定された薬物のグリア細胞疾患修飾作用
- Principal Investigator
  
  高橋慎一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Keio University
シナプス活動変容からアプローチするアルツハイマー病発症機序の解明Principal Investigator
- Principal Investigator
  
  渡部博貴
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Keio University
ミクログリア機能変容に着目したアルツハイマー病モデルの開発Principal Investigator
- Principal Investigator
  
  渡部博貴
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Keio University
Study of synaptic mechanism for Alzheimer's disease pathogenesisPrincipal Investigator
- Principal Investigator
  
  Watanabe Hirotaka
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
Development of neuron-specific analytical method to elucidate the mechanism underlying AD pathogenesisPrincipal Investigator
- Principal Investigator
  
  Watanabe Hirotaka
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Keio University

All 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Patent

[Journal Article] Single transcription factor leads pluripotent stem cells to functional microglia2022
- Author(s)
  Sonn Iki, Ozaki Fumiko, Yoshimatsu Sho, Morimoto Satoru, Watanabe Hirotaka, Okano Hideyuki
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: (in press) Issue: 1 Pages: 1-1
- DOI
  10.1186/s41232-022-00201-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21J00381, KAKENHI-PROJECT-21J12528, KAKENHI-PROJECT-21K15112, KAKENHI-PROJECT-21K08295, KAKENHI-PUBLICLY-21H05633, KAKENHI-PLANNED-21H05278, KAKENHI-PROJECT-23K24216
[Journal Article] iPS細胞を用いたアルツハイマー病の病態解析2022
- Author(s)
  渡部博貴
- Journal Title
  
  生体の科学
  
  Volume: 73 Pages: 492-493
- Data Source
  KAKENHI-PUBLICLY-21H05633
[Journal Article] Amyloid β (Aβ) ELISA of Human iPSC-Derived Neuronal Cultures2021
- Author(s)
  Watanabe Hirotaka、Murakami Rei、Okano Hideyuki
- Journal Title
  
  Methods in molecular biology
  
  Volume: - Pages: 1-9
- DOI
  10.1007/7651_2021_407
- ISBN
  9781071625842, 9781071625859
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H05633
[Journal Article] Protocols for assessing neurodegenerative phenotypes in Alzheimer’s mouse models2021
- Author(s)
  Kang Jongkyun、Watanabe Hirotaka、Shen Jie
- Journal Title
  
  STAR Protocols
  
  Volume: 2 Issue: 3 Pages: 100654-100654
- DOI
  10.1016/j.xpro.2021.100654
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-21H05633
[Journal Article] miRNA-Based Rapid Differentiation of Purified Neurons from hPSCs Advancestowards Quick Screening for Neuronal Disease Phenotypes In Vitro2020
- Author(s)
  Ishikawa Mitsuru、Aoyama Takeshi、Shibata Shoichiro、Sone Takefumi、Miyoshi Hiroyuki、Watanabe Hirotaka、Nakamura Mari、Morota Saori、Uchino Hiroyuki、Yoo Andrew S.、Okano Hideyuki
- Journal Title
  
  Cells
  
  Volume: 9 Issue: 3 Pages: 532-532
- DOI
  10.3390/cells9030532
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08668, KAKENHI-PROJECT-17K10083
[Journal Article] A combinational treatment of carotenoids decreases Aβ secretion in human neurons via β-secretase inhibition2019
- Author(s)
  Sho Misato、Ichiyanagi Naoki、Imaizumi Kent、Ishikawa Mitsuru、Morimoto Satoru、Watanabe Hirotaka、Okano Hideyuki
- Journal Title
  
  Neuroscience Research
  
  Volume: － Pages: 47-55
- DOI
  10.1016/j.neures.2019.10.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16927, KAKENHI-PROJECT-17K08668
[Journal Article] Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs2019
- Author(s)
  Nakamura Mari、Shiozawa Seiji、Tsuboi Daisuke、Amano Mutsuki、Watanabe Hirotaka、Maeda Sumihiro、Kimura Taeko、Yoshimatsu Sho、Kisa Fumihiko、Karch Celeste M.、Miyasaka Tomohiro、Takashima Akihiko、Sahara Naruhiko、Hisanaga Shin-ichi、Ikeuchi Takeshi、Kaibuchi Kozo、Okano Hideyuki
- Journal Title
  
  Stem Cell Reports
  
  Volume: 13 Issue: 4 Pages: 684-699
- DOI
  10.1016/j.stemcr.2019.08.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06472, KAKENHI-PROJECT-19K06896, KAKENHI-PUBLICLY-19H05437, KAKENHI-PROJECT-19J12871, KAKENHI-PROJECT-17K08668, KAKENHI-PROJECT-17K07383, KAKENHI-PLANNED-18H05414
[Journal Article] Dominant negative mechanism of Presenilin-1 mutations in FAD2017
- Author(s)
  Watanabe H, Shen J
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 114 Issue: 48 Pages: 12635-12637
- DOI
  10.1073/pnas.1717180114
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08668
[Journal Article] Reconsidering animal models of major depressive disorder in the elderly.2016
- Author(s)
  Toda S, Iguchi Y, Ziqiao L, Nishikawa H, Nagasawa T, Watanabe H, Minabe Y
- Journal Title
  
  Front Aging Neurosci.
  
  Volume: 8 Pages: 188-188
- DOI
  10.3389/fnagi.2016.00188
- NAID
  120005983031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H06587, KAKENHI-PROJECT-16K04429
[Patent] ミクログリア前駆細胞並びにミクログリア製造方法、製造されたミクログリア前駆細胞及びミクログリア2022
- Inventor(s)
  孫怡姫,森本悟、渡部博貴、岡野栄之
- Industrial Property Rights Holder
  孫怡姫,森本悟、渡部博貴、岡野栄之
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PUBLICLY-21H05633
[Patent] 多能性幹細胞からヒトミクログリアへの高効率分化誘導法2021
- Inventor(s)
  孫怡姫、岡野栄之、渡部博貴、森本悟
- Industrial Property Rights Holder
  孫怡姫、岡野栄之、渡部博貴、森本悟
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PUBLICLY-21H05633
[Presentation] ヒトグリア細胞を用いた神経変性疾患研究2022
- Author(s)
  渡部博貴
- Organizer
  第41回日本認知症学会学術集会/第37回日本老年精神医学会[合同開催]
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H05633
[Presentation] PS1ΔE9変異によるヒト皮質神経細胞の病態生理学的変化の検討2022
- Author(s)
  渡部博貴
- Organizer
  第41回日本認知症学会学術集会/第37回日本老年精神医学会[合同開催]
- Data Source
  KAKENHI-PROJECT-23K24216
[Presentation] ヒトグリア細胞を用いた神経変性疾患研究2022
- Author(s)
  渡部博貴
- Organizer
  第41回日本認知症学会学術集会/第37回日本老年精神医学会[合同開催]
- Invited
- Data Source
  KAKENHI-PROJECT-23K24216
[Presentation] iPS細胞由来ミクログリアの誘導法と疾患モデリング2021
- Author(s)
  孫怡姫，渡部博貴，森本悟，岡野栄之
- Organizer
  第42回日本炎症・再生医学会
- Invited
- Data Source
  KAKENHI-PUBLICLY-21H05633
[Presentation] iPS細胞由来ミクログリアの誘導法と疾患モデリング2021
- Author(s)
  孫怡姫，渡部博貴，森本悟，岡野栄之
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PUBLICLY-21H05633
[Presentation] iPS細胞由来ミクログリアの誘導法と疾患モデリング2021
- Author(s)
  孫怡姫，渡部博貴，森本悟，岡野栄之
- Organizer
  第40 回日本認知症学会学術集会
- Data Source
  KAKENHI-PUBLICLY-21H05633
[Presentation] Development of novel stem cell tool to examine physiological functions of presenilin/γ-secretase in human neurons.2019
- Author(s)
  Hirotaka Watanabe, Kent Imaizumi, Zhi Zhou, Hideyuki Okano
- Organizer
  The 42nd Annual Meeting of the Japan Neuroscience Society.
- Data Source
  KAKENHI-PROJECT-17K08668
[Presentation] ヒト人工多能性幹細胞を利用したpresenilin遺伝子変異の病態学的意義の検討2019
- Author(s)
  渡部博貴、周智、Celeste Karch、岡野栄之
- Organizer
  第３８回　日本認知症学会
- Data Source
  KAKENHI-PROJECT-17K08668
[Presentation] Presenilin and Alzheimer’s2018
- Author(s)
  Hirotaka Watanabe
- Organizer
  Blue Ribbon Panel Meeting on Setting the Future Directions of Alzheimer's Disease Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08668
[Presentation] ApoE蛋白機能解析のためのヒトiPS細胞由来アストロサイト分化誘導法の確立2018
- Author(s)
  森本悟、渡部博貴、岡本理志、岡野栄之
- Organizer
  日本認知症学会
- Data Source
  KAKENHI-PROJECT-17K08668

1. 高橋慎一 (20236285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 森本悟 (00816952)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 馬島恭子 (30812440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 岡野栄之 (60160694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 堂前直 (00321787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 高野哲也 (00725541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 掛川渉 (70383718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Shen Jie

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SHIOZAWA Seiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 今泉研人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Watanabe Hirotaka 渡部 博貴

Research Projects

Research Products

Co-Researchers

ALS運動ニューロン標的iPS細胞創薬から同定された薬物のグリア細胞疾患修飾作用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

シナプス活動変容からアプローチするアルツハイマー病発症機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ミクログリア機能変容に着目したアルツハイマー病モデルの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of synaptic mechanism for Alzheimer's disease pathogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of neuron-specific analytical method to elucidate the mechanism underlying AD pathogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Single transcription factor leads pluripotent stem cells to functional microglia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] iPS細胞を用いたアルツハイマー病の病態解析2022

Author(s)

Journal Title

Data Source

[Journal Article] Amyloid β (Aβ) ELISA of Human iPSC-Derived Neuronal Cultures2021

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Protocols for assessing neurodegenerative phenotypes in Alzheimer’s mouse models2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] miRNA-Based Rapid Differentiation of Purified Neurons from hPSCs Advancestowards Quick Screening for Neuronal Disease Phenotypes In Vitro2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A combinational treatment of carotenoids decreases Aβ secretion in human neurons via β-secretase inhibition2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dominant negative mechanism of Presenilin-1 mutations in FAD2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reconsidering animal models of major depressive disorder in the elderly.2016

Author(s)

Journal Title

DOI

NAID

Data Source

Watanabe Hirotaka 渡部博貴