Kuzuya Akira 葛谷聡

… Alternative Names

葛谷聡クズヤアキラ

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Researcher Number	30422950
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 京都大学, 医学研究科, 准教授 2017 – 2018: 京都大学, 医学研究科, 講師 2017: 京都大学, 医学研究科, その他 2016: 京都大学, 医学研究科, 助教 2007: 京大, 医学(系)研究科(研究院) 2006: 京都大学, 医学研究科, 医員
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Basic Section 53040:Nephrology-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Medium-sized Section 62:Applied informatics and related fields / Basic Section 59010:Rehabilitation science-related / Rehabilitation science/Welfare engineering / Cognitive science
Keywords	Principal Investigator シナプス / アルツハイマー病 / アミロイドβタンパク質 / アルツハイマー病創薬 / SV2B / アミロイドβ蛋白 / BACE1 / シナプス小胞蛋白2B / 認知症 Except Principal Investigator アルツハイマー病 … More / 軽度認知障害 / 慢性腎臓病 / ネフローゼ症候群 / 蛋白尿 / スリット膜 / ポドサイト / 早期アルツハイマー病 / 手段的日常生活動作 / 行動分析 / 障害メカニズム / 遂行機能 / 眼球運動 / 失行 / エラー / アイトラッキング / IADL / 生活機能 / 認知症 / 画像解析 / 免疫組織化学染色標本 / QOL / 空間疫学 / 臨床疫学 / EphrinB1 / NHERF2 / Ephrin / Neurexin / シナプス関連分子 / バイオマーカー / アルツハイマー型認知症 / 血清 / モード解析 / NMR / 振動工学 / 視空間性作業記憶 / 細目行為 / 認知メカニズム / 視線計測 / 認知機能低下 / 認知的負荷量 / 情報の抑制 / 情報の選択 / 視線分析 / 障害 / 認知科学 / 手段的生活動作 / 生活機能障害 / 生活関連動作 / マイクロスリップ / 作業記憶 / エラー分析 / 注視 / 加齢 / 回想法 / 単純接触効果 / 自伝的記憶 / エピソード記憶 / ノスタルジア / 感情 / 記憶 Less

Development research for Alzheimer's disease therapeutics targeting the mechanism of amyloid beta protein production at synapsesPrincipal Investigator
- Principal Investigator
  
  葛谷聡
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyoto University
Innovations in clinical epidemiology through spatial epidemiological analysis of images and pathological specimens
- Principal Investigator
  
  山本洋介
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Kyoto University
Role of Ephrin-Nephrin-Neurexin complex in maintaining slit diaphragm function
- Principal Investigator
  
  河内裕
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
Drug discovery research for Alzheimer's disease targeting a novel SV2B-BACE1 interactionPrincipal Investigator
- Principal Investigator
  
  Kuzuya Akira
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyoto University
Illuminating the mechanisms behind instrumental activity of daily living in people with mild cognitive impairment
- Principal Investigator
  
  Odagiri Masashi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Kyoto Tachibana University
Development of a new serum diagnostic method for Alzheimer's disease incorporating the concept of modal analysis in vibration engineering
- Principal Investigator
  
  山崎峰雄
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 62:Applied informatics and related fields
- Research Institution
  Nippon Medical School
Novel therapy for nephotic syndrome targetting synapse associated molecules in podocyte
- Principal Investigator
  
  Kawachi Hiroshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
Individual differences and functions of nostalgia: Cognitive-neural approach and their applications
- Principal Investigator
  
  Kusumi Takashi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cognitive science
- Research Institution
  Kyoto University
Underpining mechanisms of fuinctional disability of patients with mild cognitive decline
- Principal Investigator
  
  Odagiri Masashi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Kyoto Tachibana University
アルツハイマー病におけるプレセニリン1とBACE1結合の病態解明Principal Investigator
- Principal Investigator
  
  葛谷聡
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Kyoto University

All 2023 2020 2019 2018 2017 2007

All Journal Article Presentation Patent

[Journal Article] Synaptic Vesicle Protein 2B Negatively Regulates the Amyloidogenic Processing of AβPP as a Novel Interaction Partner of BACE12020
- Author(s)
  Miyamoto Masakazu、Kuzuya Akira、Noda Yasuha、Ueda Sakiho、Asada-Utsugi Megumi、Ito Shinji、Fukusumi Yoshiyasu、Kawachi Hiroshi、Takahashi Ryosuke、Kinoshita Ayae
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: Apr 6 Issue: 1 Pages: 1-13
- DOI
  10.3233/jad-200071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15365, KAKENHI-PROJECT-19H03673, KAKENHI-PROJECT-16K19479, KAKENHI-PROJECT-16H02837, KAKENHI-PROJECT-18H04041, KAKENHI-PROJECT-20K07884
[Journal Article] Development of the Reading Cognitive Test Kyoto (ReaCT Kyoto) for Early Detection of Cognitive Decline in Patients with Hearing Loss2020
- Author(s)
  Okano Takayuki、Yamamoto Yosuke、Kuzuya Akira、Egawa Naohiro、Kawakami Koji、Furuta Ichiro、Mizuno Kayoko、Fujino Kiyohiro、Kojima Ken、Omori Koichi
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 73 Issue: 3 Pages: 981-990
- DOI
  10.3233/jad-190982
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15347, KAKENHI-PROJECT-20K07883, KAKENHI-PROJECT-16H02837
[Journal Article] Two-Point Dynamic Observation of Alzheimer’s Disease Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus2019
- Author(s)
  Naoto Jingami, Kengo Uemura, Megumi Asada-Utsugi, Akira Kuzuya, Shigeki Yamada, Masatsune Ishikawa, Takashi Kawahara, Takuya Iwasaki, Masamichi Atsuchi, Ryosuke Takahashi, Ayae Kinoshita
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 72 Issue: 1 Pages: 271-277
- DOI
  10.3233/jad-190775
- NAID
  120006767911
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15448, KAKENHI-PROJECT-16H02837
[Journal Article] Increase in direct social care costs of Alzheimer's disease in Japan depending on dementia severity.2019
- Author(s)
  Takechi H, Kokuryu A, Kuzuya A, Matsunaga S
- Journal Title
  
  Geriatr Gerontol Int. 2019 Oct;19(10):1023-1029.
  
  Volume: 10 Issue: 10 Pages: 1023-1029
- DOI
  10.1111/ggi.13764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K02283, KAKENHI-PROJECT-16H02837
[Journal Article] An acute functional screen identifies an effective antibody targeting amyloid-β oligomers based on calcium imaging2018
- Author(s)
  Wang Xueying、Kastanenka Ksenia V.、Arbel-Ornath Michal、Commins Caitlin、Kuzuya Akira、Lariviere Amanda J.、Krafft Grant A.、Hefti Franz、Jerecic Jasna、Bacskai Brian J.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 4634-4634
- DOI
  10.1038/s41598-018-22979-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02837
[Journal Article] 手段的日常生活動作障害の認知メカニズム研究：認知症患者の視線行動分析を通して2017
- Author(s)
  小田桐匡，葛谷聡，麻生俊彦，上田敬太，並木千尋，武地一
- Journal Title
  
  地域ケアリング
  
  Volume: 19（9） Pages: 47-50
- Data Source
  KAKENHI-PROJECT-16K01483
[Journal Article] Presenilin 1 is involved in the maturation of β-site amyloid precursor protein-cleaving enzyme 1(BACE1).2007
- Author(s)
  Kuzuya A, Uemura K, Kitagawa N, Aoyagi N, Kihara T, Ninomiya H, Ishiura S, Takahashi R, Shimohama S.
- Journal Title
  
  Journal of Neuroscience Research 85(1)
  
  Pages: 153-165
- Data Source
  KAKENHI-PROJECT-18790595
[Patent] アルツハイマー病罹患者の認知機能障害の進行リスク又は発症リスクの検査方法、及びアルツハイマー病の検査方法2023
- Inventor(s)
  葛谷聡
- Industrial Property Rights Holder
  国立大学法人京都大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-184026
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-20K07884
[Presentation] Underpinning mechanisms of functional disability in patients with mild cognitive decline: analysis of the visuospatial working memory2020
- Author(s)
  M, Odagiri; S, Kuzuya; K, Ueda; T, Aso; H, Takechi
- Organizer
  International Neuropsychological Society 2020 Mid-Year Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01483
[Presentation] 髄液バイオマーカーを用いた軽症アルツハイマー病における漢字想起障害の臨床的意義2020
- Author(s)
  葛谷　聡
- Organizer
  第39回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16H02837
[Presentation] Underpinning mechanisms of functional disability in patients with mild cognitive decline: analysis of the visuospatial working memory2020
- Author(s)
  M, Odagiri; S, Kuzuya; K, Ueda; T, Aso; H, Takechi
- Organizer
  International Neuropsychological Society 2020 Mid-Year Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11378
[Presentation] 髄液バイオマーカー診断された軽症アルツハイマー病患者における漢字能力の臨床的意義2020
- Author(s)
  葛谷　聡
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-16H02837
[Presentation] 認知予備能が髄液アルツハイマー病バイオマーカーと認知機能におよぼす影響の検討2019
- Author(s)
  葛谷聡
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-16H02837
[Presentation] 軽度認知障害者のIADL障害の分析 -エラーとマイクロスリップの視点から-2019
- Author(s)
  芳尾拓樹，源田早希，小田桐匡，麻生俊彦，葛谷聡，上田敬太，武地一
- Organizer
  日本高次脳機能障害学会
- Data Source
  KAKENHI-PROJECT-16K01483
[Presentation] 軽度認知障害者のIADL障害の分析 -エラーとマイクロスリップの視点から-2019
- Author(s)
  芳尾拓樹，源田早希，小田桐匡，麻生俊彦，葛谷聡，上田敬太，武地一
- Organizer
  日本高次脳機能障害学会
- Data Source
  KAKENHI-PROJECT-19K11378
[Presentation] 髄液バイオマーカー診断された軽症アルツハイマー病における漢字書字能力と認知機能の検討2019
- Author(s)
  葛谷聡
- Organizer
  第38回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16H02837
[Presentation] The effect of mechanical knowledge of tools on the functional disability of elderly people with dementia2018
- Author(s)
  Masashi Odagiri, Keita Ueda, Toshihiko Aso, Satoshi Kuzuya
- Organizer
  International Neuropsychological Society 2018 Mid-Year Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01483
[Presentation] SV2B can regulate BACE1 localization in the hippocampus2017
- Author(s)
  Masakazu Miyamoto, Yasuha Noda, Akira Kuzuya, Kengo Uemura, Megumi Asada-Utsugi, Shinji Ito, Yoshiyasu Fukusumi, Hiroshi Kawachi, Ryosuke Takahashi, Ayae Kinoshita
- Organizer
  World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02837

1. Odagiri Masashi (30388904)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. Kawachi Hiroshi (60242400)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 上田敬太 (60573079)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. 福住好恭 (20609242)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 松井克之 (20256027)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 内許玉楓 (00529472)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 安田英紀 (00806490)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. Kusumi Takashi (70195444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 松田憲 (10422916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 杉森絵里子 (70709584)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 高橋英彦 (60415429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 米田英嗣 (50711595)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 野村信威 (90411719)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 麻生俊彦 (50397543)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. 山崎峰雄 (10277577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 小池薫 (10267164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 平川慶子 (30165162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 柚木知之 (50639094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 金涌佳雅 (80465343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 荒木望嗣 (10452492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 金田大太 (40564795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 金子佳賢 (80444157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 成田一衛 (20272817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 山本洋介 (30583190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 田栗正隆 (20587589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 小亀敏明 (00744111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 脇田貴文 (60456861)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 山崎大 (90836032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 陣上直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 宮本将和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 江川斉宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 武地一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kuzuya Akira 葛谷 聡

葛谷 聡 クズヤ アキラ

Research Projects

Research Products

Co-Researchers

Development research for Alzheimer's disease therapeutics targeting the mechanism of amyloid beta protein production at synapsesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Innovations in clinical epidemiology through spatial epidemiological analysis of images and pathological specimens

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of Ephrin-Nephrin-Neurexin complex in maintaining slit diaphragm function

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug discovery research for Alzheimer's disease targeting a novel SV2B-BACE1 interactionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Illuminating the mechanisms behind instrumental activity of daily living in people with mild cognitive impairment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new serum diagnostic method for Alzheimer's disease incorporating the concept of modal analysis in vibration engineering

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel therapy for nephotic syndrome targetting synapse associated molecules in podocyte

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Individual differences and functions of nostalgia: Cognitive-neural approach and their applications

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Underpining mechanisms of fuinctional disability of patients with mild cognitive decline

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アルツハイマー病におけるプレセニリン1とBACE1結合の病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Synaptic Vesicle Protein 2B Negatively Regulates the Amyloidogenic Processing of AβPP as a Novel Interaction Partner of BACE12020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of the Reading Cognitive Test Kyoto (ReaCT Kyoto) for Early Detection of Cognitive Decline in Patients with Hearing Loss2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two-Point Dynamic Observation of Alzheimer’s Disease Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus2019

Author(s)

Journal Title

DOI

NAID

Kuzuya Akira 葛谷聡

葛谷聡クズヤアキラ