mizui masayuki 水井理之

… Alternative Names

Mizui Masayuki 水井理之

MIZUI Masayuki 水井理之

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Researcher Number	30423106
Other IDs	https://orcid.org/0000-0003-2543-8108
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2023: 大阪大学, 大学院医学系研究科, 准教授 2022 – 2023: 大阪大学, 大学院医学系研究科, 講師 2019 – 2022: 大阪大学, 医学系研究科, 講師 2016 – 2018: 大阪大学, 医学系研究科, 助教 2015: 大阪大学, 医学(系)研究科(研究院), 助教 2007 – 2012: Osaka University, 微生物病研究所, 助教 2006: 大阪大学, 微生物病研究所, 特任研究員
Review Section/Research Field	Principal Investigator Collagenous pathology/Allergology / Basic Section 54020:Connective tissue disease and allergy-related / Immunology / 膠原病・アレルギー・感染症内科学 Except Principal Investigator Basic Section 53040:Nephrology-related / Medium-sized Section 53:Organ-based internal medicine and related fields / Immunology
Keywords	Principal Investigator 自己免疫 / 抗CD3抗体 / T細胞受容体 / 自己免疫疾患 / 制御性T細胞 / 炎症 / リンパ球 / 代謝調節 / 脂肪酸酸化 / グルタミン … More / Th17 / autoimmune diseases / glutaminolysis / Fatty acid / IL-17 / PPARa / 断片化抗CD3抗体 / T細胞受容体発現 / Fc不活化 / 臓器障害 / 自己抗体 / SLE / 抗CD3サイレント抗体 / 抗体 / ③自己免疫疾患 / ②抗体産生反応 / ①Ｔ細胞受容体 / regulatory T cells / antibody responses / T cell receptor / 全身性エリテマトーデス / TIM-4欠損マウス / 樹状細胞 / 樹状細細胞 / TIM-4 / 抗Tim-4抗体 / 抗Tim- 4抗体 / T細胞増殖 / 抗原提示細胞 / Tim-1 / Tim-4 / Timファミリー分子 … More Except Principal Investigator Single cell RNA seq / 腎予後 / 無作為化比較試験 / SGLT2阻害剤 / 腎移植 / エクソソーム解析 / シングルセルRNA-seq解析 / AI / AIによる腎病理解析 / オートファジー / D-アミノ酸 / シングルセルRNA解析 / AIによる腎病理診断 / 精密医療 / CKD / 腎発生 / single cell RNA解析 / 気道アレルギー / 分子標的 / セマフォリンファミリー / Plexin / 免疫制御 / リンパ球 / IL-4 / Th2 / Tim-2 / Sema4A / EBウイルス / B細胞抗原受容体 / PKN1 / Akt / plexin B2 / Sema4D / 樹状細胞 / B細胞 / T細胞 / アレルギー疾患 / プレキシン / セマフォリン Less

Dapagliflozin preserves allograft function in kidney transplant recipients (KTRs).
- Principal Investigator
  
  難波倫子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Osaka University
PPARαをターゲットとしたリンパ球代謝リモデリングによる自己免疫疾患制御Principal Investigator
- Principal Investigator
  
  水井理之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Osaka University
Development of a prognostic evaluation method for precision medicine of early-stage CKD patients
- Principal Investigator
  
  Isaka Yoshitaka
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Osaka University
Elucidation of renal disease onset and progression mechanism using single cell RNA-sequence
- Principal Investigator
  
  ISAKA YOSHITAKA
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Osaka University
Modified anti-CD3 as a therapeutic antibody for lupusPrincipal Investigator
- Principal Investigator
  
  Mizui Masayuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Osaka University
The effect of quantitative T-cell receptor down-modulation in antibody reponses and its application for autoimnune diseasesPrincipal Investigator
- Principal Investigator
  
  Mizui Masayuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Osaka University
樹状細胞表面分子による制御性T細胞機能調節機構の解明Principal Investigator
- Principal Investigator
  
  水井理之
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Roles of guidance factors in immune regulation
- Principal Investigator
  
  KIKUTANI Hitoshi
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Tim分子によるTh1/Th2反応制御機構の解明Principal Investigator
- Principal Investigator
  
  水井理之
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019 2018 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] Association between urinary uric acid excretion and kidney outcome in patients with CKD2024
- Author(s)
  Asahina Yuta、Sakaguchi Yusuke、Oka Tatsufumi、Hattori Koki、Kawaoka Takayuki、Doi Yohei、Yamamoto Ryohei、Matsui Isao、Mizui Masayuki、Kaimori Jun-Ya、Isaka Yoshitaka
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 5119-5119
- DOI
  10.1038/s41598-024-55809-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02935
[Journal Article] Development of a three-dimensional HPLC system for the determination of serine, threonine and allo-threonine enantiomers in the plasma of patients with chronic kidney disease2024
- Author(s)
  Oyaide Mai、Ishii Chiharu、Akita Takeyuki、Kimura Tomonori、Sakai Shinsuke、Mizui Masayuki、Mita Masashi、Ide Tomomi、Isaka Yoshitaka、Hamase Kenji
- Journal Title
  
  Journal of Chromatography A
  
  Volume: 1719 Pages: 464739-464739
- DOI
  10.1016/j.chroma.2024.464739
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19414, KAKENHI-PROJECT-23K14335, KAKENHI-PROJECT-23KJ1732, KAKENHI-PROJECT-22K06547, KAKENHI-PROJECT-21H02935, KAKENHI-PROJECT-23K24015
[Journal Article] Single cell RNA sequencing uncovers cellular developmental sequences and novel potential intercellular communications in embryonic kidney2021
- Author(s)
  Isao Matsui, Ayumi Matsumoto, Kazunori Inoue, Yusuke Katsuma, Seiichi Yasuda, Karin Shimada, Yusuke Sakaguchi, Masayuki Mizui, Jun-Ya Kaimori, Yoshitsugu Takabatake, Yoshitaka Isaka
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 73-73
- DOI
  10.1038/s41598-020-80154-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08725, KAKENHI-PROJECT-19K22621, KAKENHI-PROJECT-21H02935
[Journal Article] Natural and modified IL-2 for the treatment of cancer and autoimmune diseases2019
- Author(s)
  Mizui M.
- Journal Title
  
  Clin Immunol
  
  Volume: 206 Pages: 63-70
- DOI
  10.1016/j.clim.2018.11.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10001
[Journal Article] Targeting Regulatory T Cells to Treat Patients With Systemic Lupus Erythematosus2018
- Author(s)
  Masayuki Mizui and George C. Tsokos
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 印刷中
- DOI
  10.3389/fimmu.2018.00786
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10001
[Journal Article] Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II2010
- Author(s)
  Takamatsu H, Takegahara N, Nakagawa Y, Tomura M, Taniguchi M, Friedel RH, Rayburn H, Tessier-Lavigne M, Yoshida Y, Okuno T, Mizui M, Kang S, Nojima S, Tsujimura T, Nakatsuji Y, Katayama I, Toyofuku T, Kikutani H, Kumanogoh A
- Journal Title
  
  Nat Immunol.
  
  Volume: 11(7) Issue: 7 Pages: 594-600
- DOI
  10.1038/ni.1885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007, KAKENHI-PROJECT-21590196
[Journal Article] Semaphorins guide cells into the lymphatics by activating myosin II.2010
- Author(s)
  Takamatsu, H., N.Takegahara, Y.Nakagawa, M.Tomura, M.Taniguchi, R.H.Friedel, H.Rayburn, M.Tessier-Lavigne, Y.Yoshida, T.Okuno, M.Mizui, S.Kang, S.Nojima, T.Tsujimura, Y. Nakatsuji, I.Katayama, T.Toyofuku, H.Kikutani, A.Kumanogoh.
- Journal Title
  
  Nat Immunol 11
  
  Pages: 594-600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007
[Journal Article] Immune semaphorins : novel features of neural guidance molecules.2009
- Author(s)
  Mizui, M., et al.
- Journal Title
  
  J. Celin. Immunol., 29:1-11, 2009 29
  
  Pages: 1-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007
[Journal Article] Immune semaphorins: novel features of neural guidance molecules.2009
- Author(s)
  Mizui M, Kumanogoh A, Kikutani H.
- Journal Title
  
  J Clin Immunol.
  
  Volume: 29(1) Issue: 1 Pages: 1-11
- DOI
  10.1007/s10875-008-9263-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007
[Journal Article] Immune semaphorins : novel features of neural guidance molecules.2009
- Author(s)
  Mizui, M., A.Kuanogoh, H. Kikutani
- Journal Title
  
  J.Clin.Immunol. 29
  
  Pages: 1-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007
[Journal Article] Bimodal regulation of T cell-mediated immune responses by TIM-42008
- Author(s)
  Mizui, et. al.
- Journal Title
  
  International Immunology in press
- NAID
  10021241281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790681
[Journal Article] Bimodal regulation of T cell-mediated immune responses by TIM-4.2008
- Author(s)
  Mizui M, Shikina T, Arase H, Suzuki K, Yasui T, Rennert PD, Kumanogoh A, Kikutani H.
- Journal Title
  
  Int Immunol.
  
  Volume: 20(5) Issue: 5 Pages: 695-708
- DOI
  10.1093/intimm/dxn029
- NAID
  10021241281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007
[Journal Article] Bimodal regulation of T cell-mediated immune responses by TIM-4.2008
- Author(s)
  Mizui, M., T.Shikina, H.Arase, K.Suzuki, T.Yasui, P.D.Rennert, A.Kumanogoh, H.Kikutani
- Journal Title
  
  Int.Immunol. 20
  
  Pages: 695-708
- NAID
  10021241281
- Data Source
  KAKENHI-PROJECT-20229007
[Journal Article] Bimodal regulation of T cell-mediated immune responses by TIM-42008
- Author(s)
  Mizui, M., et al.
- Journal Title
  
  Int. Immunol., 20:695-708 20
  
  Pages: 695-708
- NAID
  10021241281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007
[Journal Article] Neuropilin-1 : the glue between regulatory T cells and dendritic cells?, 28 : 302-303, 2008.2008
- Author(s)
  Mizui, M., H. Kikutani
- Journal Title
  
  Immunity 28
  
  Pages: 302-303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007
[Presentation] A selective PPARa-modulator-mediated metabolic alteration ameliorates autoimmunity through restraining glutaminolysis in Th17 cells2023
- Author(s)
  Satoshi Masuyama, Masashi Morita, Tatsusada Okuno, Masayuki Mizui and Yoshitaka Isaka
- Organizer
  The 2nd International Symposium of Clinical Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08562
[Presentation] A selective PPARa modulator-mediated metabolic manipulation ameliorates autoimmunity by limiting glutaminolysis in Th17 cells2022
- Author(s)
  増山慧、水井理之、森田将史、奥野龍禎、猪阪善隆
- Organizer
  日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08562
[Presentation] Efficacy and safety of non-mitogenic anti-CD3 antibody administration in the treatment of lupus2020
- Author(s)
  Masashi Morita, Masayuki Mizui, Satoshi Masuyama and Yoshitaka Isaka
- Organizer
  European League against Rheumatism Annual Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10001
[Presentation] Comprehensive detection assay of physiological interaction partners for the Epstein-Barr virus latent membrane protein 1 by bimolecular fluorescence complementation system coupled with enhanced retrovirus mutagenesis.2010
- Author(s)
  Mizui, M., T.Yasui, K.Morita, T.Morimoto, S.Tada, H.Kikutani
- Organizer
  The 14^<th> Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases.
- Place of Presentation
  Birmingham, UK.
- Data Source
  KAKENHI-PROJECT-20229007
[Presentation] Biphasic action of Tim-4 on T cell-mediated immune responses2007
- Author(s)
  水井理之
- Organizer
  第37回日本免疫学会
- Place of Presentation
  東京
- Year and Date
  2007-11-22
- Data Source
  KAKENHI-PROJECT-18790681

1. ISAKA YOSHITAKA (00379166)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. 井上和則 (10631301)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 松井功 (60456986)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. KIKUTANI Hitoshi (80161412)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. YASUI Teruhito (60283074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. SAKAKIBARA Shuhei (10618838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山本陵平 (00533853)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 木村友則 (00631300)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 高畠義嗣 (30403075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 難波倫子 (30734420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 山中和明 (10648017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 野々村祝夫 (30263263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 土井洋平 (30846382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 今村亮一 (40456976)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 濱野高行 (50403077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 阿部豊文 (90750894)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 増山慧 (80869917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

mizui masayuki 水井 理之

Mizui Masayuki 水井 理之

MIZUI Masayuki 水井 理之

Research Projects

Research Products

Co-Researchers

Dapagliflozin preserves allograft function in kidney transplant recipients (KTRs).

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

PPARαをターゲットとしたリンパ球代謝リモデリングによる自己免疫疾患制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a prognostic evaluation method for precision medicine of early-stage CKD patients

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of renal disease onset and progression mechanism using single cell RNA-sequence

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Modified anti-CD3 as a therapeutic antibody for lupusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of quantitative T-cell receptor down-modulation in antibody reponses and its application for autoimnune diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

樹状細胞表面分子による制御性T細胞機能調節機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of guidance factors in immune regulation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Tim分子によるTh1/Th2反応制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Association between urinary uric acid excretion and kidney outcome in patients with CKD2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a three-dimensional HPLC system for the determination of serine, threonine and allo-threonine enantiomers in the plasma of patients with chronic kidney disease2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single cell RNA sequencing uncovers cellular developmental sequences and novel potential intercellular communications in embryonic kidney2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Natural and modified IL-2 for the treatment of cancer and autoimmune diseases2019

Author(s)

Journal Title

DOI

Data Source

mizui masayuki 水井理之

Mizui Masayuki 水井理之

MIZUI Masayuki 水井理之