Higuchi Hitoshi 樋口仁

… Alternative Names

HIGUCHI Hitoshi 樋口仁

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Researcher Number	30423320
Other IDs
Affiliation (Current)	2025: 岡山大学, 医療開発領域, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 岡山大学, 大学病院, 准教授 2018 – 2020: 岡山大学, 大学病院, 講師 2017: 岡山大学, 大学病院, 助教 2012 – 2016: 岡山大学, 大学病院, 講師 2012: 岡山大学, 岡山大学病院, 講師 … More 2009: Okayama University, 岡山大学病院, 助教 2009: Okayama University, 病院, 助教 2008: Okayama University, 医学部・歯学部附属病院, 助教 2007: Okayama University, 医学部歯学部・附属病院, 助教 2006: 岡山大学, 医学部・歯学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Surgical dentistry / Basic Section 57080:Social dentistry-related / Basic Section 57060:Surgical dentistry-related Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Surgical dentistry
Keywords	Principal Investigator 酸化ストレス / Transmembrane135 / 中枢神経 / 唾液分泌 / 神経変性 / 老化 / Tmem135 / 脳 / 代謝 / 唾液線 … More / ミトコンドリアダイナミクス / 唾液腺 / ミトコンドリア / 神経 / シナプス / TMEM135 / シナプス小胞 / 中枢細胞 / 遺伝子変異マウス / ショック / 術後認知症 / 麻酔薬 / Heme Oxygenase-1 / 脳・神経 / 術後認知障害 … More Except Principal Investigator サイトカイン / 炎症 / 抗炎症作用 / 過分極活性化環状ヌクレオチド依存性チャネル / 脳虚血 / 周術期 / 中枢神経系 / LPS / ストレス反応 / サイトカイン / 細胞内カルシウム動態 / ミクログリア / interleukin-6 / マイクログリア / アポトーシス / 全身麻酔 / オピオイド / オピオイド受容体 / 疼痛制御 / HCNチャネル阻害薬 / 疼痛制御作用 / 炎症性疼痛 / 術後せん妄 / 脳神経疾患 / 脳梗塞 / せん妄 / デクスメデトミジン / インターロイキン６ / レミフェンタニル / 歯科 / 視床下部室傍核 / 副腎皮質ステロイド / 糖質コルチコイド / CRH / 視床下部 / HPA axis Less

Exploration of novel regulation of salivary secretion using Tmem135 transgenic micePrincipal Investigator
- Principal Investigator
  
  樋口仁
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  Okayama University
Anti-inflammatory mechanisms via hyperpolarization-activated cyclic nucleotide-gated channel subtypes
- Principal Investigator
  
  宮脇卓也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Okayama University
Investigation of the effects of abnormal mitochondrial dynamics on salivary gland function.Principal Investigator
- Principal Investigator
  
  Hitoshi Higuchi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Okayama University
Effects of delta opioid receptor agonists on perioperative cerebral ischemia models
- Principal Investigator
  
  Maeda Shigeru
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Tokyo Medical and Dental University
  Okayama University
Mechanisms of the antinociceptive action of hyperpolarization-activated cyclic nucleotide-gated channel blockers
- Principal Investigator
  
  Miyawaki Takuya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Okayama University
Antiinflammatory and protective effect of dexmedetomidine in central nervous system
- Principal Investigator
  
  MAEDA Shigeru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Okayama University
The study of TMEM135 function in synaptic vesiclesPrincipal Investigator
- Principal Investigator
  
  Higuchi Hitoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Okayama University
anti-inflammatory effect of remifentanil
- Principal Investigator
  
  Maeda Shigeru
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Okayama University
The study of the oxidative stress-induced neurodegeneration in CNS by using Tmem135 mutant micePrincipal Investigator
- Principal Investigator
  
  HIGUCHI Hitoshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Okayama University
Reaction of HPA-axis and brain cytokines in oral inflammation model
- Principal Investigator
  
  MAEDA Shigeru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Okayama University
The Study of Protective Effect of Intravenous and Inhalation Anesthetic to Oxidative Stress in Central Nerve SystemPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Hitoshi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Okayama University
一酸化炭素吸入による中枢神経細胞の酸化ストレス軽減効果Principal Investigator
- Principal Investigator
  
  樋口仁
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Okayama University

[Journal Article] Dexmedetomidine inhibits LPS-induced inflammatory responses through peroxisome proliferator-activated receptor gamma (PPARγ) activation following binding to α2 adrenoceptors2021
- Author(s)
  Fujimoto Maki、Higuchi Hitoshi、Honda-Wakasugi Yuka、Miyake Saki、Nishioka Yukiko、Yabuki-Kawase Akiko、Maeda Shigeru、Miyawaki Takuya
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 892 Pages: 173733-173733
- DOI
  10.1016/j.ejphar.2020.173733
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10357, KAKENHI-PROJECT-17K17248
[Journal Article] Assessing the Effectiveness of Combined Analgesics for Bilateral Ramus Osteotomies2020
- Author(s)
  Maeda Shigeru、Higuchi Hitoshi、Fujimoto Maki、Miyake Saki、Honda-Wakasugi Yuka、Miyawaki Takuya
- Journal Title
  
  Anesthesia Progress
  
  Volume: 67 Issue: 3 Pages: 140-145
- DOI
  10.2344/anpr-67-01-05
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10357
[Journal Article] Metabolic alterations caused by the mutation and overexpression of the Tmem135 gene2020
- Author(s)
  Lee Wei-Hua、Bhute Vijesh J、Higuchi Hitoshi、Ikeda Sakae、Palecek Sean P、Ikeda Akihiro
- Journal Title
  
  Experimental Biology and Medicine
  
  Volume: 245 Issue: 17 Pages: 1571-1583
- DOI
  10.1177/1535370220932856
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10287
[Journal Article] Pulmonary Aspiration During Induction of General Anesthesia2020
- Author(s)
  Hayashi Reina、Maeda Shigeru、Hideki Taninishi、Higuchi Hitoshi、Miyawaki Takuya
- Journal Title
  
  Anesthesia Progress
  
  Volume: 67 Issue: 4 Pages: 214-218
- DOI
  10.2344/anpr-67-02-03
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10357
[Journal Article] Locally injected ivabradine inhibits carrageenan-induced pain and inflammatory responses via hyperpolarization-activated cyclic nucleotide-gated (HCN) channels2019
- Author(s)
  Miyake Saki、Higuchi Hitoshi、Honda-Wakasugi Yuka、Fujimoto Maki、Kawai Hotaka、Nagatsuka Hitoshi、Maeda Shigeru、Miyawaki Takuya
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 5 Pages: 0217209-0217209
- DOI
  10.1371/journal.pone.0217209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09722, KAKENHI-PROJECT-18K17224
[Journal Article] Remifentanil suppresses increase in interleukin-6 mRNA in the brain by inhibiting cyclic AMP synthesis2018
- Author(s)
  Maeda Shigeru、Andoh Tsugunobu、Onishi Rieko、Tomoyasu Yumiko、Higuchi Hitoshi、Miyawaki Takuya
- Journal Title
  
  Journal of Anesthesia
  
  Volume: 32 Issue: 5 Pages: 731-739
- DOI
  10.1007/s00540-018-2548-y
- NAID
  40021690428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11750
[Journal Article] Female patients require a higher propofol infusion rate for sedation.2017
- Author(s)
  Shigeru Maeda, Yumiko Tomoyasu, , Hitoshi Higuchi, Yuka Honda, Minako Ishii-Maruhama, Takuya Miyawaki
- Journal Title
  
  Anesth Prog
  
  Volume: 63 Issue: 2 Pages: 67-70
- DOI
  10.2344/0003-3006-63.2.67
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11750
[Journal Article] Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies2016
- Author(s)
  Wei-Hua Lee, Hitoshi Higuchi, Sakae Ikeda, Erica L Macke, Tetsuya Takimoto, Bikash R Pattnaik, Che Liu, Li-Fang Chu, Sandra M Siepka, Kathleen J Krentz, C Dustin Rubinstein, Robert F Kalejta, James A Thomson, Robert F Mullins, Joseph S Takahashi, Lawrence H Pinto, Akihiro Ikeda
- Journal Title
  
  eLife
  
  Volume: 5
- DOI
  10.7554/elife.19264
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463066
[Journal Article] Female patients require a higher propofol infusion rate for sedation.2016
- Author(s)
  4.Maeda S, Tomoyasu Y, Higuchi H, Honda Y, Ishii-Maruhama M, Miyawaki T.
- Journal Title
  
  Anesthesia Progress
  
  Volume: 63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25463135
[Journal Article] Independent factors affecting time to recovery from sedation in patients with intellectual disabilities.2015
- Author(s)
  Maeda S, Tomoyasu Y, Higuchi H, Ishii-Maruhama M, Yamane A, Yabuki A, Honda Y, Egusa M, Miyawaki T.
- Journal Title
  
  Open Dental Journal
  
  Volume: 31 Issue: 1 Pages: 146-149
- DOI
  10.2174/1874210601509010146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25463135
[Journal Article] Independent Factors Affecting Recovery Time After Sedation in Patients with Intellectual Disabilities2015
- Author(s)
  Shigeru Maeda, Yumiko Tomayasu, Hitoshi Higuchi, Minako Ishii-Maruhama, Ayaka Yamane, Akiko Yabuki, Yuka Honda, Masahiko Egusa, Takuya Miyawaki
- Journal Title
  
  The Open Dentistry Journal
  
  Volume: 9
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25463135
[Journal Article] Independent predictors of delay in emergence from general anesthesia.2015
- Author(s)
  8.Maeda S, Tomoyasu Y, Higuchi H, Ishii-Maruhama M, Egusa M, Miyawaki T.
- Journal Title
  
  Anesthesia Progress
  
  Volume: 62 Issue: 1 Pages: 8-13
- DOI
  10.2344/0003-3006-62.1.8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25463135
[Journal Article] Genetic basis of agedependent synaptic abnormalities in the retina2015
- Author(s)
  Hitoshi H, Macke EL, Lee WH, Miler SA, Xu JC, Ikeda S, Ikeda A
- Journal Title
  
  Mamm Genome
  
  Volume: 26 Issue: 1-2 Pages: 21-32
- DOI
  10.1007/s00335-014-9546-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26463066
[Journal Article] Independent predictors of delay in emergence from general anesthesia2015
- Author(s)
  Shigeru MAEDA, Yumiko TOMOYASU, Hitoshi HIGUCHI, Minako ISHII-MARUHAMA, Masahiko EGUSA, Takuya MIYAWAKI
- Journal Title
  
  Anesthesia Progress
  
  Volume: 62 Pages: 8-13
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25463135
[Journal Article] Chronic orofacial pain in dental patients: retrospective investigation over 12 years.2014
- Author(s)
  Tomoyasu Y, Higuchi H, Mori M, Takaya K, Honda Y, Yamane A, Yabuki A, Hayashi T, Ishii-Maruyama M, Jinzenji A, Maeda S, Kohjitani A, Shimada M, Miyawaki T
- Journal Title
  
  Acta Medica Okayama
  
  Volume: 68 Pages: 269-275
- NAID
  120005477125
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25463135
[Journal Article] Hemodynamic changes by drug interaction of adrenaline with chlorpromazine.2014
- Author(s)
  Higuchi H, Yabuki A, Ishii-Maruhama M, Tomoyasu Y, Maeda S, Miyawaki T
- Journal Title
  
  Anesthesia Progress
  
  Volume: 61 Issue: 4 Pages: 150-154
- DOI
  10.2344/0003-3006-61.4.150
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25463135
[Journal Article] Lidocaine on Local Anesthetic Potency in Humans: A Crossover Double-Blind Study2014
- Author(s)
  Yamane A, Higuchi H, Tomoyasu Y, Ishii-Maruhama M, Maeda S, Miyawaki T
- Journal Title
  
  Journal of Oral and Maxillofacial Surgery
  
  Volume: 73 Issue: 4 Pages: 616-621
- DOI
  10.1016/j.joms.2014.09.029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25463135
[Journal Article] Low bone mass is a risk factor in periodontal disease-related tooth loss in patients with intellectual disability.2013
- Author(s)
  Numoto Y, Mori T, Maeda S, Tomoyasu Y, Higuchi H, Egusa M, Miyawaki T
- Journal Title
  
  Open Dent J
  
  Volume: 7 Issue: 1 Pages: 157-161
- DOI
  10.2174/1874210601307010157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25463135
[Journal Article] 口腔外科手術における全身麻酔覚醒直後の興奮の要因に関する後向き研究2013
- Author(s)
  本田優花, 前田茂, 樋口仁, 友安弓子, 石井美菜子, 林知子，他
- Journal Title
  
  日歯麻誌
  
  Volume: 41 Pages: 21-25
- NAID
  10031145187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25463135
[Journal Article] Shimada M.Combination of midazolam and a cyclooxygenase-2 inhibitor inhibits lipopolysaccharide-induced interleukin-6 production in human peripheral blood mononuclear cells2012
- Author(s)
  Miyawaki T, Kohjitani A, Maeda S, Higuchi H, Arai Y, Tomoyasu Y
- Journal Title
  
  Immunopharmacol Immunotoxicol
  
  Volume: 34 Pages: 79-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592258
[Journal Article] The influence of oral VPA on the required dose of propofol for sedation during dental treatment in patients with mental retardation: a prospective observer-blinded cohort study2012
- Author(s)
  Ishii M, Higuchi H, Maeda S, Tomoyasu Y, Egusa M, Miyawaki T
- Journal Title
  
  Epilepsia
  
  Volume: 53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592258
[Journal Article] idazolam is associated with delay in recovery and agitation after ambulatory general anesthesia for dental treatment in patients with disabilities: a retrospective cohort study2012
- Author(s)
  Maeda S, Tomoyasu Y, Higuchi H, Mori T, Egusa M, Miyawaki T
- Journal Title
  
  J Oral Maxillofac Surg
  
  Volume: 70 Pages: 1315-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592258
[Journal Article] Liposome-encapsulated midazolam for oral administration2011
- Author(s)
  Tomoyasu Y, Yasuda T, Maeda S, Higuchi H, Miyawaki T
- Journal Title
  
  J Liposome Res
  
  Volume: 21 Pages: 166-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592258
[Journal Article] Induction of apoptotic change in the rat hippocampus caused by ferric nitrilotriacetate2011
- Author(s)
  Maeda S, Arai Y, Higuchi H, Tomoyasu Y, Mizuno R, Takahashi T, Miyawaki T
- Journal Title
  
  Redox Rep
  
  Volume: 16 Pages: 114-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592258
[Journal Article] Allergic reactions to local anesthetics in dental patients: analysis of intracutaneous and challenge tests2011
- Author(s)
  Tomoyasu Y, Mukae K, Suda M, Hayashi T, Ishii M, Sakaguchi M, Watanabe Y, Jinzenji A, Arai Y, Higuchi H, Maeda S, Miyawaki T
- Journal Title
  
  Open Dent J
  
  Volume: 5 Pages: 146-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592258
[Journal Article] Effects of midazolam and phenobarbital on brain oxidative reactions induced by pentylenetetrazole in a convulsion model2011
- Author(s)
  Arai Y, Maeda S, Higuchi H, Tomoyasu Y, Shimada M, Miyawaki T
- Journal Title
  
  Immunopharmacol Immunotoxicol
  
  Volume: 34 Pages: 216-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592258
[Journal Article] Propofol increases the rate of albumin-unbound free midazolam in serum albumin solution2011
- Author(s)
  Ohmori J, Maeda S, Higuchi H, Ishii M, Arai Y, Tomoyasu Y, Kohjitani A, Shimada M, Miyawaki T
- Journal Title
  
  J Anesth
  
  Volume: 25 Pages: 618-20
- NAID
  10029601499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592258
[Journal Article] Dental Sedation for Patients with Intellectual Disability: A Prospective Study of Manual Control versus Bispectral Index-Guided Target-Controlled Infusiomaedan of Propofol2011
- Author(s)
  Sakaguchi M, Higuchi H, Maeda S, Miyawaki T
- Journal Title
  
  Journal of Clinical Anesthesia
  
  Volume: 23 Pages: 636-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592258
[Journal Article] Oxidative changes in the rat brain by intraperitoneal injection of ferric nitrilotriacetate2009
- Author(s)
  I chiro Nakatsuka, Shigeru Maeda, Tsugunobu Andoh, Yukiko Hayashi, Ryuichiro Mizuno, Hitoshi Higuchi, Takuya Miyawaki
- Journal Title
  
  Redox Rep 14
  
  Pages: 109-114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791513
[Journal Article] Heme oxygenase-1 induction in the brain during lipopolysaccharide-inducedacute inflammation2008
- Author(s)
  S Maeda, I Nakatsuka, Y Hayashi, H Higuchi, M Shimada and T Miyawaki
- Journal Title
  
  Neuropsychiatr Dis Treat 4(3)
  
  Pages: 663-667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791513
[Journal Article] Heme oxygenase-1 induction in the brain during lipopolysaccharide-induced acute inflammation2008
- Author(s)
  S higeru Maeda, Ichiro Nakatsuka, Yukiko Hayashi, Hitoshi Higuchi, Masahiko Shimada, Takuya Miyawaki
- Journal Title
  
  Neuropsychiatr Dis Treat 4
  
  Pages: 663-667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791513
[Journal Article] Oxidative Changes in the Rat Brain by Intraperitoneal Injection of Ferric Nitrilotriacetate
- Author(s)
  I Nakatsuka, S Maeda, T Ando, Y Hayashi, R Mizuno, H Higuchi and T Mivawaki
- Journal Title
  
  Redox Report (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791513
[Journal Article] Heme Oxygenase-1 Induction in the Brain during Lipopolysaccharid - induced Acute Inflammation
- Author(s)
  Maeda S, Nakatsuka I, Hayashi Y, Higuchi H, et. al.
- Journal Title
  
  Neuropsychiatric Disease and Treatment (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18791496
[Presentation] HCNチャネル遮断薬はどのアイソフォームを介して抗炎症作用を示すのか2022
- Author(s)
  三宅沙紀, 松田怜奈, 樋口仁, 宮脇卓也
- Organizer
  第50回日本歯科麻酔学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-22K10169
[Presentation] Delta opioid receptor ligand suppresses increase in IL-6 in cultured microglia2021
- Author(s)
  S Maeda, S Miyake, M Fujimoto, Y Nishioka, H Hitoshi, T Miyawaki
- Organizer
  IADR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10357
[Presentation] デクスメデトミジンはペルオキシソーム増殖因子活性化受容体γ（PPARγ）活性を介してLPS誘発性炎症反応を抑制する2020
- Author(s)
  藤本磨希，若杉優花，三宅沙紀，樋口　仁，前田　茂，宮脇卓也
- Organizer
  第48回日本歯科麻酔学会総会
- Data Source
  KAKENHI-PROJECT-19K10357
[Presentation] Brain protection of dexmedetomidine in perioperative model2018
- Author(s)
  Maeda S, Onishi R, Honda-Wakasugi Y, Yabuki-Kawase A, Higuchi H, Miyawaki T
- Organizer
  15th International Federation of Dental Anesthesiology Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11750
[Presentation] The inhibitory effect of locally administered ivabradine on inflammatory pain2018
- Author(s)
  Saki Miyake, Yuka Honda-Wakasugi, Akiko Yabuki-Kawase, Hitoshi Higuchi, Shigeru Maeda, Takuya Miyawaki
- Organizer
  96th General Session & Exhibition of the IADR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09722
[Presentation] Effect of Dexmedetomidine on Brain Ischemia2017
- Author(s)
  Maeda S, Onishi R, Honda-Wakasugi Y, Yabuki-Kawase A, Higuchi H, Miyawaki T
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11750
[Presentation] The role of Tmem135 in retinal aging and mitochondrial dynamics2015
- Author(s)
  Wei-Hua Lee, Hitoshi Higuchi, Erica Macke, Che Liu, Li- Fang Chu, John B. Troy, Robert F. Mullins, Joseph Takahashi, Lawrence Pinto, Akihiro Ikeda
- Organizer
  The Annual Meeting of the Association for Research in Vision and Ophthalmology
- Place of Presentation
  Denver, Colorado, USA
- Year and Date
  2015-05-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463066
[Presentation] レミフェンタニルの抗炎症作用について2015
- Author(s)
  前田　茂, 大西　梨恵子, 友安弓子, 樋口　仁, 宮脇卓也
- Organizer
  第43回日本歯科麻酔学会総会
- Place of Presentation
  東京
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-25463135
[Presentation] 静脈内鎮静法において麻酔薬の投与量に影響を与える要因についての多変量解析2013
- Author(s)
  前田　茂，友安弓子，樋口　仁，他
- Organizer
  第41回日本歯科麻酔学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25463135
[Presentation] Locally Injected Dexmedetomidine Enhances Local Anesthetic Potency in Humans2013
- Author(s)
  YAMANE, A. YABUKI, Y. TOMOYASU, H. HIGUCHI, S. MAEDA, and T. MIYAWAKI
- Organizer
  IADR
- Place of Presentation
  Seattle(USA)
- Year and Date
  2013-03-23
- Data Source
  KAKENHI-PROJECT-22592258
[Presentation] Effect of Midazolam on Blood Pressure in Hypertensive Dental Patients2013
- Author(s)
  Y. WATANABE, Y. TOMOYASU, H. HIGUCHI, S. MAEDA, and T. MIYAWAKI
- Organizer
  IADR
- Place of Presentation
  Seattle(USA)
- Year and Date
  2013-03-23
- Data Source
  KAKENHI-PROJECT-22592258
[Presentation] Drug Interaction between Adrenaline and Chlorpromazine2013
- Author(s)
  H. HIGUCHI, A. YABUKI, S. MAEDA, Y. TOMOYASU, and T. MIYAWAKI
- Organizer
  IADR
- Place of Presentation
  Seattle (USA)
- Year and Date
  2013-03-23
- Data Source
  KAKENHI-PROJECT-22592258
[Presentation] Drug Interaction between Adrenaline and Chlorpromazine2013
- Author(s)
  Higuchi H
- Organizer
  International Association of Dental Research
- Place of Presentation
  米国　シアトル
- Data Source
  KAKENHI-PROJECT-22592258
[Presentation] 麻酔管理前に開口状態の予測が困難であった１症例について2013
- Author(s)
  前田　茂，丸濵美菜子，友安弓子，樋口　仁，江草正彦，宮脇拓也
- Organizer
  第30回日本障害者歯科学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25463135
[Presentation] Locally Injected Dexmedetomidine Induces Peripheral Vasoconstriction via Alpha-2 Adrenoceptors2013
- Author(s)
  YABUKI, A. YAMANE, Y. TOMOYASU, H. HIGUCHI, S. MAEDA, and T. MIYAWAKI
- Organizer
  IADR
- Place of Presentation
  Seattle (USA)
- Year and Date
  2013-03-23
- Data Source
  KAKENHI-PROJECT-22592258
[Presentation] Locally Injected Dexmedetomidine Inhibits Carrageenin-Induced TNF-Alpha Production in Injected Region2012
- Author(s)
  Takuya Miyawaki, Shintaro Skegawa, Miho Inoue, Hitoshi Higuchi, Yumiko Tomoyasu, Minako Ishii, Shigeru Maeda
- Organizer
  ASA
- Place of Presentation
  Wasington DC(USA)
- Year and Date
  2012-10-17
- Data Source
  KAKENHI-PROJECT-22592258
[Presentation] Valproate increases the rate of protein-unbound free propofol in human serum2012
- Author(s)
  Minako Ishii, Satoru Sakurai, Hitoshi Higuchi, Yumiko Tomoyasu, Sigeru Maeda, Takuya Miyawaki
- Organizer
  ASA
- Place of Presentation
  Wasington DC(USA)
- Year and Date
  2012-10-17
- Data Source
  KAKENHI-PROJECT-22592258
[Presentation] Effects of Remifentanil against Septic Shock Model2011
- Author(s)
  Y. Tomoyasu, S. Maeda, H. Higuchi, M. Suda, M. Ishii, T. Miyawaki
- Organizer
  SFN Washington
- Place of Presentation
  DC(USA)
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22592258
[Presentation] Loccally injected dexmedetomidine inhibits carrageenin-induced inflammatory reaction in injected region2011
- Author(s)
  Sintarou Sukegawa, Inoue M, Hitoshi Higuchi, Yumiko Tomoyasu, Sigeru Maeda, Takuya Miyawaki
- Organizer
  ASA
- Place of Presentation
  Chicago (USA)
- Year and Date
  2011-10-19
- Data Source
  KAKENHI-PROJECT-22592258
[Presentation] Loccally injected dexmedetomidine inhibits carrageenin-induced inflammatory reaction in injected region2011
- Author(s)
  T.Hayashi, H.Higuchi, M.Ishii, Y.Tomoyasu, Y.Arai, S.Maeda, T.Miyawaki
- Place of Presentation
  IADR/San Diego (USA)
- Year and Date
  2011-03-19
- Data Source
  KAKENHI-PROJECT-22592258
[Presentation] Loccally injected dexmedetomidine inhibits carrageenin-induced inflammatory reaction in injected region2011
- Author(s)
  M.Ishii, H.Higuchi, M.Sakaguchi, T.Hayashi, Y.Arai, Y.Tomoyasu, S.Maeda, T.Miyawaki
- Place of Presentation
  IADR/San Diego (USA)
- Year and Date
  2011-03-19
- Data Source
  KAKENHI-PROJECT-22592258
[Presentation] Loccally injected dexmedetomidine inhibits carrageenin-induced inflammatory reaction in injected region2010
- Author(s)
  Mai Sakaguchi, Hitoshi Higuchi, Yumiko Tomoyasu, Shigeru Maeda, Takuya Miyawaki
- Place of Presentation
  IADR/Barcelona(Spain)
- Year and Date
  2010-07-17
- Data Source
  KAKENHI-PROJECT-22592258
[Presentation] 中枢神経興奮薬によるアセチルコリン受容体サブタイプの変化と, それに対する静脈麻酔薬の影響について2009
- Author(s)
  前田茂, 新井由起子, 須田通代, 樋口仁, 宮脇卓也
- Organizer
  第37回日本歯科麻酔学会総会・学術集会
- Place of Presentation
  名古屋
- Year and Date
  2009-10-09
- Data Source
  KAKENHI-PROJECT-20791513
[Presentation] Hemorrhagic shock followed by resuscitation induces heme oxyganase-1 mRNA in rat brain2008
- Author(s)
  Higuchi H, Maeda S, Takahashi T, Hayashi Y, Miyawaki T
- Organizer
  Neuroscience 2008
- Place of Presentation
  Washington DC
- Year and Date
  2008-11-18
- Data Source
  KAKENHI-PROJECT-20791513
[Presentation] Hemorrhagic shock followed by resuscitation induces heme oxyganase-1 mRNA inrat2008
- Author(s)
  H Higuchi, S Maeda, T Takahashi, T Miyawaki
- Organizer
  Neuroscience 2008
- Place of Presentation
  ワシントンDC
- Year and Date
  2008-11-18
- Data Source
  KAKENHI-PROJECT-20791513
[Presentation] Brain reactions to continuous intracerebroventricular injection of ferric nitrilotriacetate(Fe-NTA)2008
- Author(s)
  M aeda S, Hayashi Y, Mizuno R, Higuchi H, Miyawaki T
- Organizer
  Neuroscience 2008
- Place of Presentation
  Washington DC
- Year and Date
  2008-11-18
- Data Source
  KAKENHI-PROJECT-20791513
[Presentation] Anti-inflammatory effect of remifentanil in the mouse brain after systemic lipopolysaccharide administration
- Author(s)
  Maeda S, Ohnishi R, Tomoyasu Y, Higuchi H, Miyawaki T
- Organizer
  Society for Neuroscience 2014
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-25463135
[Presentation] デクスメデトミジンは局所投与によってカラゲニン誘発炎症性疼痛を抑制する
- Author(s)
  本田　優花，樋口　仁，友安　弓子，前田　茂，宮脇　卓也
- Organizer
  日本歯科麻酔学会
- Place of Presentation
  新潟
- Year and Date
  2014-10-11 – 2014-10-12
- Data Source
  KAKENHI-PROJECT-25463135
[Presentation] Additive Effects of Dexmedetomidine and Indomethacin on Acute Inflammatory Pain
- Author(s)
  Y Honda, H Higuchi, M Ishii-Maruhama, Y Tomoyasu, S Maeda, T Miyawaki
- Organizer
  General Session of IADR
- Place of Presentation
  Boston, USA
- Year and Date
  2015-03-11 – 2015-03-14
- Data Source
  KAKENHI-PROJECT-25463135
[Presentation] The role of Tmem135 in retinal aging and mitochondrial dynamics
- Author(s)
  Wei-Hua Lee, Hitoshi Higuchi, Erica Macke,, Che Liu , Li-Fang Chu , John B. Troy , Robert F. Mullins, Joseph Takahashi , Lawrence Pinto , Akihiro Ikeda
- Organizer
  The Annual Meeting of the Association for Research in Vision and Ophthalmology 2015
- Place of Presentation
  Denver, Colorado, USA
- Year and Date
  2015-05-03 – 2015-05-07
- Data Source
  KAKENHI-PROJECT-26463066
[Presentation] Effect of Capnography on Hypoxemia During Deep Sedation
- Author(s)
  K Takaya, H Higuchi, A Yabuki, M Ishii-Maruhama, Y Tomoyasu, S Maeda, M Egusa, T Miyawaki
- Organizer
  General Session of IADR
- Place of Presentation
  Boston, USA
- Year and Date
  2015-03-11 – 2015-03-14
- Data Source
  KAKENHI-PROJECT-25463135
[Presentation] 知的障害は全静脈麻酔からの覚醒時間に影響を及ぼす
- Author(s)
  樋口　仁，前田　茂，丸濱　美菜子，秦泉寺　紋子，須田　道代，渡辺　禎久，齋田　拓也,　山根　舞,　友安　弓子,　宮脇　卓也
- Organizer
  日本歯科麻酔学会
- Place of Presentation
  新潟
- Year and Date
  2014-10-11 – 2014-10-12
- Data Source
  KAKENHI-PROJECT-25463135
[Presentation] Intellectual disability associated with delayed recovery from total intravenous anesthesia
- Author(s)
  H Higuchi, S Maeda, M Ishii-Maruhama, A Yabuki, A Yamane, Y Honda, Y Tomoyasu, M Egusa, T Miyawaki
- Organizer
  General Session of IADR
- Place of Presentation
  Boston, USA
- Year and Date
  2015-03-11 – 2015-03-14
- Data Source
  KAKENHI-PROJECT-25463135

1. MAEDA Shigeru (50253000)

# of Collaborated Projects: 4 results

# of Collaborated Products: 48 results
2. MIYAWAKI Takuya (00219825)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
3. TOMOYASU Yumiko (40594809)

# of Collaborated Projects: 2 results

# of Collaborated Products: 37 results
4. ANDOH Tsugunobu (50333498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SOGAWA Chiharu (10253022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TAJIRI Ayako

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. IKEDA Akihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Higuchi Hitoshi 樋口 仁

HIGUCHI Hitoshi 樋口 仁

Research Projects

Research Products

Co-Researchers

Exploration of novel regulation of salivary secretion using Tmem135 transgenic micePrincipal Investigator

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Anti-inflammatory mechanisms via hyperpolarization-activated cyclic nucleotide-gated channel subtypes

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Investigation of the effects of abnormal mitochondrial dynamics on salivary gland function.Principal Investigator

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Effects of delta opioid receptor agonists on perioperative cerebral ischemia models

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Mechanisms of the antinociceptive action of hyperpolarization-activated cyclic nucleotide-gated channel blockers

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Antiinflammatory and protective effect of dexmedetomidine in central nervous system

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The study of TMEM135 function in synaptic vesiclesPrincipal Investigator

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anti-inflammatory effect of remifentanil

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The study of the oxidative stress-induced neurodegeneration in CNS by using Tmem135 mutant micePrincipal Investigator

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Reaction of HPA-axis and brain cytokines in oral inflammation model

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The Study of Protective Effect of Intravenous and Inhalation Anesthetic to Oxidative Stress in Central Nerve SystemPrincipal Investigator

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一酸化炭素吸入による中枢神経細胞の酸化ストレス軽減効果Principal Investigator

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[Journal Article] Dexmedetomidine inhibits LPS-induced inflammatory responses through peroxisome proliferator-activated receptor gamma (PPARγ) activation following binding to α2 adrenoceptors2021

Author(s)

Journal Title

Higuchi Hitoshi 樋口仁

HIGUCHI Hitoshi 樋口仁