CHEN Li 陳リー

… Alternative Names

陳りーチェンリー

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Researcher Number	30425681
Affiliation (based on the past Project Information) *help	2010: 東京医科大学 2009: 東京都医学研究機構, 研究員 2007 – 2009: Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 研究員 2008: Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 研究員
Review Section/Research Field	Principal Investigator Pathological medical chemistry Except Principal Investigator Biological Sciences / Anesthesiology/Resuscitation studies
Keywords	Principal Investigator 血管新生 / siRNA / 低酸素反応因子 / 癌抑制因子 / 虚血 / 動物モデル / 低酸素反応性因子 / RNA干渉 / 遺伝子導入 / 転写因子 / 翻訳因子 … More Except Principal Investigator … More 低酵素反応性因子 / siRNA / 血管新生 / 生物モデル / 転写因子 / 翻訳調節因子 / 虚血性疾患 / 低酸素反応性因子 / 癌抑制因子 / 虚血 / RNA干渉 / 遺伝子導入 / 動物モデル / アウトロサイト / Int6-HIF2α / 脳蘇生 / 脳虚血 / 神経栄養因子 / ミトコンドリア / MUSTag / RCR / CRC / Int6SiRNA / 前脳虚血 / MMPS / アストロサイト / Int6・HIF2α / SiRNA / GFAP Less

KOマウスを用いた、Int6による機能性血管新生機序の解明Principal Investigator
- Principal Investigator
  
  陳リー
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
癌化における新規血管新生制御機構の解明
- Principal Investigator
  
  芝崎太
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
New approach to establish brain resuscitation targeting for Int6-HIF2α originated from astrocyte.
- Principal Investigator
  
  UCHINO Hiroyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Tokyo Medical University
Analysis and clinical application of normal blood vessel inducement by Int6-siRNAPrincipal Investigator
- Principal Investigator
  
  CHEN Li
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Metropolitan Organization for Medical Research

All 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book Patent

[Book] MUSTagによるバイオマーカー診断2009
- Author(s)
  芝崎太、森實芳仁、槇坂典子、陳リー
- Total Pages
  2
- Publisher
  Medical Science Digest
- Data Source
  KAKENHI-PROJECT-20013051
[Book] 超高感度多項目解析(MUSTag)法を用いた次世代バイオマーカー測定2009
- Author(s)
  芝崎太、森實芳仁、槇坂典子、陳リー、児玉崇
- Total Pages
  5
- Publisher
  医療と検査機器・試薬
- Data Source
  KAKENHI-PROJECT-20013051
[Journal Article] Cyclophilin D-sensitive mitochondrial permeability transition in adult human brain and liver mitochondria.2011
- Author(s)
  Hansson MJ, Morota S, Chen L, Matsuyama N, Suzuki Y, Nakajima S, Tanoue T, Omi A, Shibasaki F, Shimazu M, Ikeda Y, Uchino H, Elmer E J
- Journal Title
  
  Neurotrauma. 28(1)
  
  Pages: 143-53
- Data Source
  KAKENHI-PROJECT-20591819
[Journal Article] Int6/eIF3e Silencing Promotes Functional Blood Vessel Outgrowth and Enhances Wound Healing by Upregulating HIF2α Expression2010
- Author(s)
  Chen L, Endler A, Uchida K, Horiguchi S, Morizane Y, Iijima O, Toi M, Shibasaki F
- Journal Title
  
  Circulation (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013051
[Journal Article] Hypoxia and Angiogenesis : Regulation of Hypoxia-Inducible Factors via Novel Binding Factors (Review Article)2009
- Author(s)
  Chen L, Endler A, Shibasaki F:
- Journal Title
  
  Exp.Mol.Med. 41
  
  Pages: 849-857
- Data Source
  KAKENHI-PROJECT-20013051
[Journal Article] Int6 as a novel regulator of normal vessel formation through hypoxia inducible factor 2 alpha.2009
- Author(s)
  Futoshi Shibasaki, Li Chen, Kazuyo Uchida, Alexander Endler
- Journal Title
  
  Exp.Mol.Med. in press
  
  Pages: 0-0
- Data Source
  KAKENHI-PROJECT-19590327
[Journal Article] 最新イムノPCR法:MUSTag法を用いた極微量タンパク質の同時多項目測定2008
- Author(s)
  森實芳仁、石川雄一郎、Li Chen、内田和代、芝崎太
- Journal Title
  
  実験医学 26(11)
  
  Pages: 802-810
- Data Source
  KAKENHI-PROJECT-19590327
[Journal Article] 超高感度多項目解析(MUSTag)法による臨床診断への応用2008
- Author(s)
  芝崎太、森實芳仁、石川雄一郎, 槇坂典子、小俣結子、陳リー、内田和代
- Journal Title
  
  臨床病理 56(9)
  
  Pages: 1759-1765
- NAID
  10024960491
- Data Source
  KAKENHI-PROJECT-19590327
[Journal Article] Mammalian tumor suppressor Int6 specifically targets HIF-2alpha to degradation by hypoxia- and pVHL- independent regulation.2007
- Author(s)
  Chen L, Uchida K, Endler A, Shibasaki F.
- Journal Title
  
  J Biol Chem. 282(17)
  
  Pages: 12707-16
- Data Source
  KAKENHI-PROJECT-19590327
[Journal Article] Mammalian tumor suppressor Int6 specifically targets HIF-2alpha to degradation by hypoxia-and pVHL-independent regulation.2007
- Author(s)
  Chen L., Uchida K., Endler A., Shibasaki F.
- Journal Title
  
  J Biol Chem. 282(17)
  
  Pages: 12707-12716
- Data Source
  KAKENHI-PROJECT-19590327
[Journal Article] Int6 as a novel regulator of normal vessel formation through hypoxia inducible factor 2 alpha. (Review Article)
- Author(s)
  Futoshi Shibasaki, Li Chen, Kazuyo Uchida, Alexander Endler
- Journal Title
  
  Exp. Mol. Med (in press)
- Data Source
  KAKENHI-PROJECT-20013051
[Journal Article] Int6 as a novel regulator of normal vessel formation through hypoxia inducible factor 2 alpha. (Review Article)
- Author(s)
  Futoshi Shibasaki, Li Chen, Kazuyo Uchida, Alexander Endler
- Journal Title
  
  Exp. Mol. Med (in press)
- Data Source
  KAKENHI-PROJECT-19590327
[Patent] 細胞死を予防するための医薬剤2009
- Inventor(s)
  芝崎太、陳リー
- Industrial Property Rights Holder
  財団法人東京都医学研究機構
- Industrial Property Number
  2009-070529
- Filing Date
  2009-03-23
- Data Source
  KAKENHI-PROJECT-19590327
[Patent] 細胞死を予防するための医薬剤2009
- Inventor(s)
  芝崎太, 陳リー
- Industrial Property Rights Holder
  (財)東京都医学研究機構
- Filing Date
  2009
- Data Source
  KAKENHI-PROJECT-20013051
[Presentation] 脳虚血性神経細胞死メカニズムとInt6/HIF2α情報伝達系の連関解析2010
- Author(s)
  宮下亮一,内野博之,陳リー,櫻井陽,芝崎太
- Organizer
  第164回東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-20591819
[Presentation] Int6はHIF2αを負に制御する正常血管新生のマスタースイッチとして作用する2009
- Author(s)
  芝崎太, 陳リー、内田和代、Alexander Endler、堀口慎一郎、内野博之
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  神奈川・横浜
- Data Source
  KAKENHI-PROJECT-20013051
[Presentation] 超高感度同時多項目測定法(MUSTag法)を用いた血管新生因子のプロファイリング2009
- Author(s)
  森實芳仁、陳リー、芝崎太
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  神奈川・横浜
- Data Source
  KAKENHI-PROJECT-20013051
[Presentation] siRNA-Int6 triggers normal angiogenesis directly by hypoxia-independent stabilization of HIF2alpha2008
- Author(s)
  F., Shibasaki, L., Chen, Toi
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19590327
[Presentation] Int6のノックダウンによる低酸素反応性因子(HIF2α)の活性調節と正常血管創生2008
- Author(s)
  陳リー, 内田和代, Alexander Endler, 芝崎太
- Organizer
  第6回 Cell Biology Summer Meeting 2008
- Place of Presentation
  千葉・鴨川
- Data Source
  KAKENHI-PROJECT-19590327
[Presentation] Int6によるHIF2αの低酸素非依存的な正常血管新生制御とInt6-siRNAを用いた創薬2008
- Author(s)
  芝崎太、陳リー、内田和代、Alexander Endler
- Organizer
  BMB2008
- Place of Presentation
  兵庫・神戸
- Data Source
  KAKENHI-PROJECT-20013051
[Presentation] Int6のノックダウンによる低酸素反応性因子(HIF2α)の活性調節と正常血管創生2008
- Author(s)
  陳リー、内田和代、Alexander Endler, 芝崎太
- Organizer
  第6回Cell Biology Summer Meeting
- Place of Presentation
  千葉・鴨川
- Data Source
  KAKENHI-PROJECT-19590327
[Presentation] siRNA-Int6 triggers normal angiogenesis directly by hypoxia-independent stabilization of HIF2alpha2008
- Author(s)
  F., Shibasaki, L., Chen and Toi
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20013051
[Presentation] Int6によるHIF2αの低酸素非依存的な正常血管新生制御と Int6-siRNA を用いた創薬2008
- Author(s)
  芝崎太, 陳リー, 内田和代, Alexander Endler
- Organizer
  BMB2008
- Place of Presentation
  兵庫・神戸
- Data Source
  KAKENHI-PROJECT-19590327
[Presentation] siR:NA-Int6による低酸素反応性因子(HIF2α)の活性調節と正常血管創生との関係2008
- Author(s)
  陳リー, 内田和代, Alexander Endler, 芝崎太
- Organizer
  BMB2008
- Place of Presentation
  兵庫・神戸
- Data Source
  KAKENHI-PROJECT-19590327
[Presentation] Novel Function of Int6/HIF2α Pathway in Physiological Angiogenesis2008
- Author(s)
  F., Shibasaki, L., Chen, K., Uchida, A., Endler, S., Horiguchi, Y., Suzuki and M., Toi
- Organizer
  KSMBMB
- Place of Presentation
  Seoul, Korea
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-20013051
[Presentation] eIF3e/int6 Specifically Degradate HIF-2a By Hypoxia- And pVHL-Independent Regulation2008
- Author(s)
  Li Chen, Masakazu Toi, Futoshi Shibasaki1
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  Nagoya Congress center
- Data Source
  KAKENHI-PROJECT-19590327
[Presentation] siRNA-Int6による低酸素反応性因子 (HIF2α) の活性調節と正常血管創生との関係2008
- Author(s)
  陳リー、内田和代、Alexander Endler、芝崎太
- Organizer
  BMB2008
- Place of Presentation
  兵庫・神戸
- Data Source
  KAKENHI-PROJECT-20013051
[Presentation] Novel Function of Int6/HIF2α Pathway in Physiological Angiogenesis2008
- Author(s)
  F., Shibasaki, L., Chen, K., Uchida, A., Endler, S., Horiguchi, Y., Suzuki, M., Toi
- Organizer
  KSMBMB
- Place of Presentation
  Seoul, Korea
- Year and Date
  2008-10-30
- Data Source
  KAKENHI-PROJECT-19590327
[Presentation] siRNA-Int6による低酸素反応性(HIF2α)の活性調節と正常血管との関係2008
- Author(s)
  Li Chen、内田和代、Alexander Endler, 芝崎太
- Organizer
  第81回日本生化学会大会第31回日本生化学学会大会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-19590327
[Presentation] Int6のノックダウンによる低酸素反応性因子 (HIF2α) の活性調節と正常血管創生2008
- Author(s)
  陳リー、内田和代、Alexander Endler, 芝崎太
- Organizer
  第6回Cell Biology Summer Meeting 2008
- Place of Presentation
  千葉・鴨川
- Data Source
  KAKENHI-PROJECT-20013051
[Presentation] 新規結合因子eIF3e/int6によるHIF2aの低酸素非依存的な制御機序2007
- Author(s)
  陳リー, 内田和代, Alexander Endler, 飯島修, 芝崎太
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-19590327
[Presentation] 低酸素因子HIF2aに関わるInt6のNegative Feedback 制御2007
- Author(s)
  陳リー内田和代、飯島修、森實芳仁、芝崎太
- Organizer
  第5回がんとハイポキシア研究会
- Year and Date
  2007-12-01
- Data Source
  KAKENHI-PROJECT-19590327
[Presentation] 低酸素因子HIF-2□の新規抑制因子eIF3e/int6による制御機序の解明2007
- Author(s)
  陳リー, 内田和代, Alexander Endler, 飯島修, 芝崎太
- Organizer
  セルバイオロジーサマーミーティング
- Place of Presentation
  伊東
- Data Source
  KAKENHI-PROJECT-19590327
[Presentation] HIF2αの新規抑制因子Int6による制御機構とint6-siRNAを用いた正常血管新生2007
- Author(s)
  陳リー, 芝崎太
- Organizer
  がん、分子標的治療研究会
- Place of Presentation
  大阪国際交流センター
- Year and Date
  2007-07-06
- Data Source
  KAKENHI-PROJECT-19590327
[Presentation] Int6; New Target for Angiogensis(1) eIF3e/int6 Specifically Targets HIF-2a for Degradation By Hypoxia- And pVHL-Independent Regulation.2007
- Author(s)
  Li Chen, Kazuyo Uchida, Alexander Endler, Osamu Iijima and Futoshi Shibasaki
- Organizer
  4th Annual Symposium of the American Heart Association Council on Basic Cardiovascular Science
- Place of Presentation
  the Keystone Conference Center, Keystone, Colorado, USA
- Data Source
  KAKENHI-PROJECT-19590327
[Presentation] 新規結合因子Int6/eIF3eによるHIF2aの低酸素非依存的な制御2007
- Author(s)
  陳リー内田和代、Alexander Endler、飯島修、芝崎太
- Organizer
  第30回日本分子生物会年会・第80回日本生化学学会大会合同大会
- Place of Presentation
  神奈川・横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19590327
[Presentation] 低酸素因子HIF2aに関わるInt6のNegative Feedback制御2007
- Author(s)
  陳リー, 内田和代, Alexander Endler, 飯島修, 森實芳仁, 芝崎太
- Organizer
  第5回がんとハイポキシア研究会
- Place of Presentation
  がんセンター東病院内講堂
- Year and Date
  2007-12-01
- Data Source
  KAKENHI-PROJECT-19590327
[Presentation] Int6 Triggers Normal Angiogenesis in Mouse Skin Directly by Hypoxia-Independent Stabilisation of HIF-2a2007
- Author(s)
  Li Chen, Kazuyo Uchida, Alexander Endler, Shin-ichiro Horiguchi, Yosuke Suzuki and Futoshi Shibasaki
- Organizer
  第66回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19590327
[Presentation] Int6 for Angiogenesis(1) eIF3e/int6 Specifically Targets HIF-2a For Degradation By Hypoxia-And pVHL-Independent Regulation2007
- Author(s)
  Li Chen, Kazuyo Uchida, Alexander Endler, Osamu Iijima and Futoshi Shibasaki
- Organizer
  第4回Annual Symposium the American Heart Association
- Place of Presentation
  keystone(アメリカ)
- Data Source
  KAKENHI-PROJECT-19590327
[Presentation] Int6 Specifically Targets HIF-2a to Degradation By Hypoxia- And pVHL-Independent Regulation.2007
- Author(s)
  陳リー内田和代、Alexander Endler、飯島修、芝崎太
- Organizer
  第6回Cell Biology Summer Meeting 2007
- Data Source
  KAKENHI-PROJECT-19590327

1. SHIBASAKI Futoshi (90300954)

# of Collaborated Projects: 3 results

# of Collaborated Products: 38 results
2. TOI Masakazu (10207516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. UCHINO Hiroyuki (60266476)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 福井秀公 (90349499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 奈倉武郎 (80421030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

CHEN Li 陳 リー

陳 りー チェン リー

Research Projects

Research Products

Co-Researchers

KOマウスを用いた、Int6による機能性血管新生機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

癌化における新規血管新生制御機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New approach to establish brain resuscitation targeting for Int6-HIF2α originated from astrocyte.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis and clinical application of normal blood vessel inducement by Int6-siRNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] MUSTagによるバイオマーカー診断2009

Author(s)

Total Pages

Publisher

Data Source

[Book] 超高感度多項目解析(MUSTag)法を用いた次世代バイオマーカー測定2009

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Cyclophilin D-sensitive mitochondrial permeability transition in adult human brain and liver mitochondria.2011

Author(s)

Journal Title

Data Source

[Journal Article] Int6/eIF3e Silencing Promotes Functional Blood Vessel Outgrowth and Enhances Wound Healing by Upregulating HIF2α Expression2010

Author(s)

Journal Title

Data Source

[Journal Article] Hypoxia and Angiogenesis : Regulation of Hypoxia-Inducible Factors via Novel Binding Factors (Review Article)2009

Author(s)

Journal Title

Data Source

[Journal Article] Int6 as a novel regulator of normal vessel formation through hypoxia inducible factor 2 alpha.2009

Author(s)

Journal Title

Data Source

[Journal Article] 最新イムノPCR法:MUSTag法を用いた極微量タンパク質の同時多項目測定2008

Author(s)

Journal Title

Data Source

[Journal Article] 超高感度多項目解析(MUSTag)法による臨床診断への応用2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Mammalian tumor suppressor Int6 specifically targets HIF-2alpha to degradation by hypoxia- and pVHL- independent regulation.2007

Author(s)

Journal Title

Data Source

[Journal Article] Mammalian tumor suppressor Int6 specifically targets HIF-2alpha to degradation by hypoxia-and pVHL-independent regulation.2007

Author(s)

Journal Title

Data Source

[Journal Article] Int6 as a novel regulator of normal vessel formation through hypoxia inducible factor 2 alpha. (Review Article)

Author(s)

Journal Title

Data Source

[Journal Article] Int6 as a novel regulator of normal vessel formation through hypoxia inducible factor 2 alpha. (Review Article)

Author(s)

Journal Title

Data Source

CHEN Li 陳リー

陳りーチェンリー