OHORI Hisatsugu 大堀久詔

… Alternative Names

大堀久詔オオホリヒサツグ

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Researcher Number	30431555
Affiliation (based on the past Project Information) *help	2012: 東北大学, 医学部附属病院, 助教 2010: 東北大学, 医学部附属病院, 助教
Review Section/Research Field	Except Principal Investigator Clinical oncology
Keywords	Except Principal Investigator 放射線防護作用 / 抗がん剤 / 浸潤抑制 / 血管新生阻害 / ミエローマ / がん治療 / マルチターゲット / 発がん予防活性 / 転移抑制活性 / 腫瘍血管阻害活性 … More / 誘導体 / がん幹細胞 / NF-κBシグナル伝達阻害 / 抗腫瘍活性 / クルクミン Less

Development of a new cancer chemotherapy by using curcumin analogs
- Principal Investigator
  
  SHIBATA Hiroyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Akita University

All 2012 2011 2010

All Journal Article Presentation Patent

[Journal Article] The curcumin analog GO-Y030 is a novel inhibitor of IKKB that suppresses NF-KB signaling and induces apoptosis.2011
- Author(s)
  Shibata H, Iwabuchi Y, Uehara Y, Ohori H, et al
- Journal Title
  
  Cancer Science
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo2011
- Author(s)
  Kudo C, Yamakoshi H, Sato A, Nanjo H, Ohori H, Ishioka C, Iwabuchi Y, Shibata H.
- Journal Title
  
  BMC Pharmacology
  
  Volume: 28
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] Novel curcumin analogs, GO-Y030 and GO-Y078, are multi-targeted agents for multiple myeloma with enhanced abilities2011
- Author(s)
  Kudo C, Yamakoshi H, Sato A, Ohori H, Ishioka C, Iwabuchi Y, Shibata H.
- Journal Title
  
  Anticancer Research
  
  Volume: 31(11) Pages: 3719-3726
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] KSRP/FUBP2 is a binding protein of GO-Y086, a cytotoxic curcumin analogue.2010
- Author(s)
  Shibata H, Iwabuchi Y, Ohori H, et al
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 1 Pages: 273-276
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501041
[Journal Article] KSRP/FUBP2 is a binding protein of GO-Y086, a cytotoxic curcumin analogue2010
- Author(s)
  Yamakoshi, H, Kanoh, N, Kudo, C, Sato, A, Ueda, K, Muroi, M, Kon, S, Satake, M, Ohori, O, Ishioka, C, Oshima, Y, Osada, H, Chiba, N, Shibata H, Iwabuchi, Y.
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 1(6) Pages: 273-276
- Data Source
  KAKENHI-PROJECT-22501041
[Patent] ビス(アリールメチリデン)アセトン化合物、抗癌剤、発癌予防剤、Ki-Ras、ErbB2、c-Myc及びCyclinD1の発現抑制剤、β-カテニン分解剤並びにp53の発現増強剤2012
- Inventor(s)
  柴田浩行,岩渕好治,大堀久詔,山越博幸,角道祐一
- Industrial Property Rights Holder
  国立大学法人東北大学
- Filing Date
  2012-08-03
- Overseas
- Data Source
  KAKENHI-PROJECT-22501041
[Patent] BIS(ARYLMETHYLIDENE9ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF KI-RAS, ERBB2, C-MYC AND CYCLINE D1,β-CATENIN-DEGRADATING AGENT, P53 EXPRESSION ENHANCER2012
- Inventor(s)
  Hiroyuki Shibata, Yoshiharu Iwabuchi, Hisatsugu Ohori, Hiroyuki Yamakoshi, Yuichi Kakudo
- Industrial Property Rights Holder
  National University Corporation Tohoku University
- Filing Date
  2012-05-15
- Overseas
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] 新規クルクミン類縁体による抗腫瘍効果の増強とそのメカニズムの検討2011
- Author(s)
  工藤千枝子, 山越博幸, 大堀久詔, 佐藤温子, 石岡千加史, 岩渕好治, 柴田浩行
- Organizer
  第135回東北大学加齢医学研究所集談会
- Place of Presentation
  仙台市
- Year and Date
  2011-01-28
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] 東北大学病院腫瘍内科のセカンドオピニオン外来の現状と役割2010
- Author(s)
  加藤俊介, 森隆弘, 砦田浩行, 下平秀樹, 角道祐一, 大塚和令, 高橋信, 高橋雅信, 大堀久詔, 秋山聖子, 佐々木厳, 古山美智子, 本間とし子, 原沙絵, 石岡千加史
- Organizer
  第48回日本癌治療学会学術集会
- Place of Presentation
  京都府
- Year and Date
  2010-10-28
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] Novel curcumin analogs have anti-tumor potentials against myeloma cells through the suppression of IRF4/MUM1 function2010
- Author(s)
  Kudo, C., Yamakoshi, H., Sato, A., Ohori, H., Ishioka, C., Iwabuchi, Y., Shibata, H.
- Organizer
  第69回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22501041
[Presentation] Novel curcumin analogs have anti-tumor potentials against myeloma cells through the suppression of IRF4/MLTM l function2010
- Author(s)
  Ohori H, Iwabuchi Y, Shibata h, et al
- Organizer
  69^(th) annual meeting of the Japanese Cancer Association
- Place of Presentation
  Osaka, Japan
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22501041

1. SHIBATA Hiroyuki (50260071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. IWABUCHI Yoshiharu (20211766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. UEHARA Yoshihiko (30223499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

OHORI Hisatsugu 大堀 久詔

大堀 久詔 オオホリ ヒサツグ

Research Projects

Research Products

Co-Researchers

Development of a new cancer chemotherapy by using curcumin analogs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The curcumin analog GO-Y030 is a novel inhibitor of IKKB that suppresses NF-KB signaling and induces apoptosis.2011

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo2011

Author(s)

Journal Title

Data Source

[Journal Article] Novel curcumin analogs, GO-Y030 and GO-Y078, are multi-targeted agents for multiple myeloma with enhanced abilities2011

Author(s)

Journal Title

Data Source

[Journal Article] KSRP/FUBP2 is a binding protein of GO-Y086, a cytotoxic curcumin analogue.2010

Author(s)

Journal Title

Data Source

[Journal Article] KSRP/FUBP2 is a binding protein of GO-Y086, a cytotoxic curcumin analogue2010

Author(s)

Journal Title

Data Source

[Patent] ビス(アリールメチリデン)アセトン化合物、抗癌剤、発癌予防剤、Ki-Ras、ErbB2、c-Myc及びCyclinD1の発現抑制剤、β-カテニン分解剤並びにp53の発現増強剤2012

Inventor(s)

Industrial Property Rights Holder

Filing Date

Data Source

[Patent] BIS(ARYLMETHYLIDENE9ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF KI-RAS, ERBB2, C-MYC AND CYCLINE D1,β-CATENIN-DEGRADATING AGENT, P53 EXPRESSION ENHANCER2012

Inventor(s)

Industrial Property Rights Holder

Filing Date

Data Source

[Presentation] 新規クルクミン類縁体による抗腫瘍効果の増強とそのメカニズムの検討2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 東北大学病院腫瘍内科のセカンドオピニオン外来の現状と役割2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Novel curcumin analogs have anti-tumor potentials against myeloma cells through the suppression of IRF4/MUM1 function2010

Author(s)

Organizer

Data Source

[Presentation] Novel curcumin analogs have anti-tumor potentials against myeloma cells through the suppression of IRF4/MLTM l function2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

OHORI Hisatsugu 大堀久詔

大堀久詔オオホリヒサツグ