KUSANO Teruo 草野輝男

Researcher Number	30434129
Other IDs
Affiliation (Current)	2023: 日本医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2012 – 2015: 日本医科大学, 医学部, 助教 2009 – 2010: 日本医科大学, 医学部, 助教
Review Section/Research Field	Except Principal Investigator Pathological medical chemistry / Bacteriology (including Mycology) / Bacteriology (including mycology)
Keywords	Except Principal Investigator キサンチン酸化還元酵素 / 活性酸素 / キサンチン脱水素酵素 / キサンチン酸化酵素 / 抗痛風薬 / mitoNEET / 鉄硫黄クラスター / 好熱菌 / 分子病態学 / スーパーオキシド … More / トランスジェニックマウス / キサンチチン酸化酵素 / キサンチチン脱水素酵素 / フラビン酵素 / モリブデン酵素 / ノックインマウス / 酸化酵素型-脱水素酵素型変換 / モリブデン酸素 / 虚血再灌流障害 / 全脳虚血 / 脳虚血 / 一酸化窒素 / xanthine oxidase / xanthine dehydrogenase / repurfusion injury / brain ischemia / febuxostat / 筋萎縮性側索硬化症 / 抗痛風剤 / プリン代謝 / 金属蛋白質 / 構造機能生理 / シアノバクテリア / レドックス / 構造生物学 / オミックス解析 / 構造機能 / 鉄硫黄タンパク質 / プロテオーム / 構造生物 / 機能生理 / 構造、生理 / システム生理学 / 細菌 Less

Structure-function studies of bacterial mitoNEET system
- Principal Investigator
  
  Iwasaki Toshio
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Nippon Medical School
Systemic and long term analysys of O2- hyperproduction mice
- Principal Investigator
  
  OKAMOTO Ken
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nippon Medical School
Effects of Change in Purine Metabolism on Accumulation of Aggregated Proteins in the Cell
- Principal Investigator
  
  NISHINO Takeshi
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
Structure-function of bacterial mitoNEET homologs
- Principal Investigator
  
  IWASAKI TOSHIO
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nippon Medical School
Phasogenesis study of XOR mutant knock-in mouse.
- Principal Investigator
  
  OKAMOTO Ken, 西野朋子
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nippon Medical School

All 2015 2013 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] Evaluation of Neuronal Protective Effects of Xanthine Oxidoreductase Inhibitors on Severe Whole-brain Ischemia in Mouse Model and Analysis of Xanthine Oxidoreductase Activity in the Mouse Brain2015
- Author(s)
  Suzuki G, Okamoto , Kusano T, Matsuda Y, Fuse A, Yokota H.
- Journal Title
  
  Neurologia medico-chirurgica
  
  Volume: 55 Issue: 1 Pages: 77-85
- DOI
  10.2176/nmc.oa.2013-0307
- NAID
  130004922260
- ISSN
  0470-8105, 1349-8029
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590393
[Journal Article] Chemical Nature and Reaction Mechanisms of the Molybdenum Cofactor of Xanthine Oxidoreductase.2013
- Author(s)
  Okamoto K, Kusano K, Nishino T
- Journal Title
  
  Curr Pharm Des
  
  Volume: 19 Pages: 2006-2014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590393
[Journal Article] Chemical Nature and Reaction Mechanisms of the Molybdenum Cofactor of Xanthine Oxidoreductase.2013
- Author(s)
  K. Okamoto, T. Kusano, T. Nishino.
- Journal Title
  
  Current Pharmaceutical Design
  
  Volume: 19 Pages: 2606-2614
- DOI
  10.2174/1381612811319140010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570198, KAKENHI-PROJECT-24590393, KAKENHI-PROJECT-24659144
[Presentation] G1H-G93A 遺伝子導入マウスの呈する筋萎縮性側索硬化症へのキサンチン酸化還元酵素阻害剤の影響2012
- Author(s)
  草野輝男、加藤信介、加藤雅子、宮川拓也、西野武士
- Organizer
  第８５回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24659144
[Presentation] Characterization of the extremophile homologs of mitoNEET. (#P117)2012
- Author(s)
  Hagiuda, E., Miyajima-Nakano, Y., Ohmori, D., Kusano, T., Matsushita, S., Dikanov, S.A., Kumasaka, T., Iwasaki, T.
- Organizer
  9th International Congress on Extremophiles
- Place of Presentation
  Sevilla, Spain
- Data Source
  KAKENHI-PROJECT-24659202
[Presentation] Characterization of the extremophile homologs of mitoNEET2012
- Author(s)
  Hagiuda, E., Miyajima-Nakano, Y., Ohmori, D., Kusano, T., Matsushita, S., Dikanov, S.A., Kumasaka, T., Iwasaki, T.
- Organizer
  9th International Congress on Extremophiles
- Place of Presentation
  Sevilla, Spain
- Data Source
  KAKENHI-PROJECT-24659202
[Presentation] G1H-G93A遺伝子導入マウスの呈する筋萎縮性側索硬化症へのキサンチン酸化還元酵素阻害剤の影響2012
- Author(s)
  草野輝男、加藤信介、加藤雅子、宮川拓也、西野武士
- Organizer
  第85回日本生化学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24659144
[Presentation] 14th International Symposium on Purine and Pyrimidine Metabolism in Man Reaction mechanism and substrate binding mode of xanthine oxidoreductase.2011
- Author(s)
  Ken Okamoto、Yuko Kawaguchi、Teruo Kusano、Tomohiro Matsumura 1、Koji Matsumoto、Takeshi Nishino
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] Reaction mechanism and substrate binding mode of xanthine oxidoreductase.2011
- Author(s)
  Ken Okamoto、Yuko Kawaguchi、Teruo Kusano、Tomohiro Matsumura1、Koji Matsumoto、Takeshi Nishino
- Organizer
  14th International Symposium on Purine and Pyrimidine Metabolism in Man
- Place of Presentation
  東京
- Year and Date
  2011-02-20
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] ウシキサンチン酸化還元酵素と天然基質キサンチンとの反応中間体結晶構造Structure of xanthine oxidoreductase in action ; Reaction intermediate structure of milk xanthine oxidoreductase and natural substrate xanthine.2010
- Author(s)
  Ken Okamoto, Tomohiro Matsumura, Kusano Teruo, Koji Matsumoto, Takeshi Nishino
- Organizer
  2010年日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] キサンチン酸化還元酵素の基質結合様式と基質活性化機構2009
- Author(s)
  岡本研, 松村智裕, 草野輝男, 松本浩二, 西野武士
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] 哺乳類ヘムペルオキシダーゼによる一重項酸素の生成2009
- Author(s)
  辻田和宏, 草野輝男, 牧内正男, 西野朋子, 柿沼カツ子
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] ブチロフィリンが有す多機能B30.2/SPRYドメインとミルクキサンチン脱水素酵素との結合様式について2009
- Author(s)
  西野朋子, 李穎, 岡本研, 草野輝男, 川口裕子, 松村智裕, 他
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] 新規キサンチン酸化還元酵素剤FYX-051の酵素学的,構造生物学的解析2009
- Author(s)
  松本浩二, 岡本研, 松村智裕, 草野輝男, 西野武士
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] 近赤外極微弱光検出装置を用いたヘムペルオキシダーゼ由来の一重項酸素の定量的測定法2009
- Author(s)
  牧内正男, 辻田和宏, 草野輝男, 西野朋子, 柿沼カツ子
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-20590317
[Presentation] knock-outマウスを用いたラクトペルオキシダーゼの組織局在の網羅的解析2009
- Author(s)
  草野輝男, 松田陽子, 西野朋子, 石渡俊行, 内藤善哉, 西野武士
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-20590317

1. OKAMOTO Ken (60267143)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. NISHINO Takeshi (40094312)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
3. IWASAKI TOSHIO (40277497)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. KUMASAKA Takashi (30291066)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. IWASAKI Hideo (00324393)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. MATSUMURA Tomohiro (20297930)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. MIYAGAWA Takuya (50596559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 西野朋子 (80075613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results

KUSANO Teruo 草野 輝男

Research Projects

Research Products

Co-Researchers

Structure-function studies of bacterial mitoNEET system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Systemic and long term analysys of O2- hyperproduction mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of Change in Purine Metabolism on Accumulation of Aggregated Proteins in the Cell

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structure-function of bacterial mitoNEET homologs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Phasogenesis study of XOR mutant knock-in mouse.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Evaluation of Neuronal Protective Effects of Xanthine Oxidoreductase Inhibitors on Severe Whole-brain Ischemia in Mouse Model and Analysis of Xanthine Oxidoreductase Activity in the Mouse Brain2015

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Chemical Nature and Reaction Mechanisms of the Molybdenum Cofactor of Xanthine Oxidoreductase.2013

Author(s)

Journal Title

Data Source

[Journal Article] Chemical Nature and Reaction Mechanisms of the Molybdenum Cofactor of Xanthine Oxidoreductase.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] G1H-G93A 遺伝子導入マウスの呈する筋萎縮性側索硬化症へのキサンチン酸化還元酵素阻害剤の影響2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Characterization of the extremophile homologs of mitoNEET. (#P117)2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Characterization of the extremophile homologs of mitoNEET2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] G1H-G93A遺伝子導入マウスの呈する筋萎縮性側索硬化症へのキサンチン酸化還元酵素阻害剤の影響2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 14th International Symposium on Purine and Pyrimidine Metabolism in Man Reaction mechanism and substrate binding mode of xanthine oxidoreductase.2011

Author(s)

Data Source

[Presentation] Reaction mechanism and substrate binding mode of xanthine oxidoreductase.2011

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

KUSANO Teruo 草野輝男