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KUSHIYAMA Akifumi  櫛山 暁史

… Alternative Names

櫛山 暁史  クシヤマ アキフミ

櫛山 曉史  クシヤマ アキフミ

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Researcher Number 30435820
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-1385-7487
Affiliation (Current) 2022: 明治薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help 2019 – 2020: 明治薬科大学, 薬学部, 教授
2016 – 2018: 公益財団法人朝日生命成人病研究所, その他部局等, 教授(移行)
2014 – 2015: 公益財団法人朝日生命成人病研究所, その他部局等, 教授
2011 – 2013: 公益財団法人朝日生命成人病研究所, その他部局等, 准教授
2010: 公益財団法人朝日生命成人病研究所, 准教授 … More
2008 – 2009: The Institute for Adult Diseases, Asahi Life Foundation, その他部局, 准教授
2008: The Institute for Adult Diseases, Asahi Life Foundation, その他部局等, 准教授
2007: The Institute for Adult Diseases, Asahi Life Foundation, その他部局, 准教授 Less
Review Section/Research Field
Principal Investigator
Metabolomics / Circulatory organs internal medicine / Basic Section 59040:Nutrition science and health science-related
Except Principal Investigator
Basic Section 08030:Family and consumer sciences, and culture and living-related
Keywords
Principal Investigator
マクロファージ / 生活習慣病 / キサンチンオキシダーゼ / 尿酸代謝 / 核酸代謝 / 動脈硬化症 / 血管内皮機能 / 血管新生 / RELMβ / 粥状動脈硬化症 … More / 分子血管病態学 / レジスチン様分子 / インスリン抵抗性 / メタボリックシンドローム / NASH モデル / 自然免疫 / Relmβ / 分子血管病態 / 尿酸 / プリン体代謝異常 / 糖尿病 / 非アルコール性脂肪肝炎 / 肥満 / CKD / プリン体 … More
Except Principal Investigator
食物繊維 / 健康寿命 / アンケート調査 / 動物実験 / 血液生化学分析 Less
  • Research Projects

    (7 results)
  • Research Products

    (161 results)
  • Co-Researchers

    (51 People)
  •  食物繊維による健康長寿への可能性

    • Principal Investigator
      南 道子
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 08030:Family and consumer sciences, and culture and living-related
    • Research Institution
      Tokyo Gakugei University
  •  The essence of health disorder caused by purine bodies as the substratesPrincipal Investigator

    • Principal Investigator
      櫛山 暁史
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Meiji Pharmaceutical University
  •  Related elucidation of the tissue-specific pudding metabolism state and lifestyle-related diseasePrincipal Investigator

    • Principal Investigator
      Kushiyama Akifumi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      The Institute for Adult Diseases Asahi Life Foundation
  •  Elucidation of pathogenesis of the onset of lifestyle-related diseases due to oxidative stress derived from diet componentsPrincipal Investigator

    • Principal Investigator
      Kushiyama Akifumi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      The Institute for Adult Diseases Asahi Life Foundation
  •  The role of resistin-like molecules in natural immune system involving insulin resistance.Principal Investigator

    • Principal Investigator
      KUSHIYAMA Akifumi
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Metabolomics
    • Research Institution
      The Institute for Adult Diseases Asahi Life Foundation
  •  Investigation for the effects of macrophage-derived resistin like molecule on development of atherosclerosisPrincipal Investigator

    • Principal Investigator
      KUSHIYAMA Akifumi
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      公益財団法人朝日生命成人病研究所
      The Institute for Adult Diseases, Asahi Life Foundation
  •  Investigation of roles of resistin like molecule beta in pathogenesis of atherosclerosisPrincipal Investigator

    • Principal Investigator
      KUSHIYAMA Akifumi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Metabolomics
    • Research Institution
      The Institute for Adult Diseases, Asahi Life Foundation

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Book Patent

  • [Book] 最新基礎栄養学2019

    • Author(s)
      南 道子、櫛山櫻、篠田粧子、大池秀明、西村直道、佐川まさの、阿部志磨子、江口昭彦、雨海照祥、原一雄
    • Total Pages
      194
    • Publisher
      医歯薬出版  第9版
    • ISBN
      9784263707470
    • Data Source
      KAKENHI-PROJECT-19K02314
  • [Book] 糖尿病の療養指導Q&A vol.22019

    • Author(s)
      櫛山暁史他
    • Total Pages
      167
    • Publisher
      医歯薬出版株式会社
    • ISBN
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Book] 『ここまで明らかになった!尿酸代謝ワールドと高尿酸血症の病態解明~診療と医学の最前線~』(動脈硬化(尿酸と血管リモデリング)の形成と進展 アテローム性動脈硬化)2015

    • Author(s)
      櫛山暁史
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Book] 生体の科学2014

    • Author(s)
      櫛山暁史
    • Publisher
      金原一郎医学医療振興財団
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Journal Article] 若年層の食の課題と家庭科の食の授業2021

    • Author(s)
      斎藤美奈子、櫛山櫻、南道子
    • Journal Title

      東京学芸大学紀要

      Volume: 72 Pages: 323-338

    • Open Access
    • Data Source
      KAKENHI-PROJECT-19K02314
  • [Journal Article] Prolyl isomerase Pin1 interacts with adipose triglyceride lipase and negatively controls both its expression and lipolysis2021

    • Author(s)
      Yusuke Nakatsu, Takeshi Yamamotoya, Mizuki Okumura, Tetsuhiro Ishii, Mayu Kanamoto, Miki Naito, Mikako Nakanishi, Shunya Aoyama, Yasuka Matsunaga, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Tomoichiro Asano
    • Journal Title

      Metabolism

      Volume: 15 Pages: 154459-154459

    • DOI

      10.1016/j.metabol.2020.154459

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08982, KAKENHI-PROJECT-19K11784, KAKENHI-PROJECT-19K17986, KAKENHI-PROJECT-20H03732, KAKENHI-PROJECT-18K08502
  • [Journal Article] 運動習慣の有無による食品と栄養素の摂取状況2021

    • Author(s)
      渕上美咲、南道子、櫛山櫻
    • Journal Title

      東京学芸大学紀要

      Volume: 72 Pages: 339-350

    • NAID

      120007046367

    • Open Access
    • Data Source
      KAKENHI-PROJECT-19K02314
  • [Journal Article] Carnosic Acid and Carnosol Activate AMPK, Suppress Expressions of Gluconeogenic and Lipogenic Genes, and Inhibit Proliferation of HepG2 Cells2021

    • Author(s)
      Hasei S, Yamamotoya T, Nakatsu Y, Ohata Y, Itoga S, Nonaka Y, Matsunaga Y, Sakoda H, Fujishiro M, Kushiyama A, Asano T.
    • Journal Title

      Int J Mol Sci .

      Volume: 22 Pages: 4040-4040

    • DOI

      10.3390/ijms22084040

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K11784, KAKENHI-PROJECT-20H03732
  • [Journal Article] Quantitative sonographic assessment of quadriceps muscle thickness for fall injury prediction in patients undergoing maintenance hemodialysis: an observational cohort study2021

    • Author(s)
      Sai A, Tanaka K, Ohashi Y, Kushiyama A, Tanaka Y, Motonishi S, Sakai K, Hara S, Ozawa T.
    • Journal Title

      BMC Nephrol

      Volume: 22 Pages: 191-191

    • DOI

      10.1186/s12882-021-02347-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Journal Article] Prolyl Isomerase Pin1 in Metabolic Reprogramming of Cancer Cells2020

    • Author(s)
      Nakatsu Yusuke、Yamamotoya Takeshi、Ueda Koji、Ono Hiraku、Inoue Masa-Ki、Matsunaga Yasuka、Kushiyama Akifumi、Sakoda Hideyuki、Fujishiro Midori、Matsubara Akio、Asano Tomoichiro
    • Journal Title

      Cancer letters

      Volume: 470 Pages: 106-114

    • DOI

      10.1016/j.canlet.2019.10.043

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-19K11784, KAKENHI-PROJECT-19K17986, KAKENHI-PROJECT-16K09784, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-19K08982, KAKENHI-PROJECT-20H03732
  • [Journal Article] Effect of postprandial hyperglycemia at clinic visits on the incidence of retinopathy in patients with type 2 diabetes: An analysis using real-world long-term follow-up data2020

    • Author(s)
      Takao Toshiko、Takahashi Kazuyuki、Yoshida Yoko、Kushiyama Akifumi、Onishi Yukiko、Tahara Tazu、Shimmei Asuka、Kikuchi Takako、Suka Machi、Yanagisawa Hiroyuki、Iwamoto Yasuhiko、Kasuga Masato
    • Journal Title

      J Diabetes Investig

      Volume: - Pages: 930-937

    • DOI

      10.1111/jdi.13194

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Journal Article] Comparisons between dipeptidyl peptidase-4 inhibitors and other classes of hypoglycemic drugs using two distinct biomarkers of pancreatic beta-cell function: A meta-analysis2020

    • Author(s)
      Takahashi Masahiro、Shibasaki Misa、Echizen Hirotoshi、Kushiyama Akifumi
    • Journal Title

      PLOS ONE

      Volume: 15

    • DOI

      10.1371/journal.pone.0236603

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Journal Article] Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice:2019

    • Author(s)
      Inoue Masa-Ki、Matsunaga Yasuka、Nakatsu Yusuke、Yamamotoya Takeshi、Ueda Koji、Kushiyama Akifumi、Sakoda Hideyuki、Fujishiro Midori、Ono Hiraku、Iwashita Misaki、Sano Tomomi、Nishimura Fusanori、Morii Kenichi、Sasaki Kensuke、Masaki Takao、Asano Tomoichiro
    • Journal Title

      Diabetol Metab Syndr

      Volume: 11 Pages: 1-11

    • DOI

      10.1186/s13098-019-0454-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-19K02314, KAKENHI-PROJECT-19K11784, KAKENHI-PROJECT-18K17071, KAKENHI-PROJECT-19K17986, KAKENHI-PROJECT-17K09850, KAKENHI-PROJECT-17K16150
  • [Journal Article] Treatment of two mitochondrial disease patients with a combination of febuxostat and inosine that enhances cellular ATP2019

    • Author(s)
      Kamatani Naoyuki、Kushiyama Akifumi、Toyo-oka Licht、Toyo-oka Teruhiko
    • Journal Title

      Journal of Human Genetics

      Volume: 64 Pages: 351-353

    • DOI

      10.1038/s10038-018-0558-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Journal Article] Characteristics and Early Hypoglycemic Medications of Patients at Risk of Progression to Type 2 Diabetes in Japan: A Retrospective Cohort Study of Health Checkup and Claims Data2019

    • Author(s)
      Kanai Norihito、Shono Aiko、Kushiyama Akifumi、Akazawa Manabu
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 42 Issue: 12 Pages: 2016-2023

    • DOI

      10.1248/bpb.b19-00505

    • NAID

      130007754618

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Journal Article] Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects Against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice2019

    • Author(s)
      Mizuno Yu、Yamamotoya Takeshi、Nakatsu Yusuke、Ueda Koji、Matsunaga Yasuka、Inoue Masa-Ki、Sakoda Hideyuki、Fujishiro Midori、Ono Hiraku、Kikuchi Takako、Takahashi Masahiro、Morii Kenichi、Sasaki Kensuke、Masaki Takao、Asano Tomoichiro、Kushiyama Akifumi
    • Journal Title

      Int J Mol Sci

      Volume: 20 Pages: 4680-4680

    • DOI

      10.3390/ijms20194680

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-19K11784, KAKENHI-PROJECT-19K17986, KAKENHI-PROJECT-17K16150
  • [Journal Article] Association of gait speed and grip strength with risk of cardiovascular events in patients on haemodialysis: a prospective study2019

    • Author(s)
      Kuki Atsumi、Tanaka Kentaro、Kushiyama Akifumi、Tanaka Yoshihide、Motonishi Shuta、Sugano Yasuji、Furuya Toru、Ozawa Takashi
    • Journal Title

      BMC Nephrology

      Volume: 20

    • DOI

      10.1186/s12882-019-1370-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Journal Article] Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case-Control Study, Human Cell Cultures, and In Vivo Preclinical Testing.8 Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case-Control Study, Human Cell Cultures, and In Vivo Preclinical Testing.2019

    • Author(s)
      Suzuki Nobumi、Niikura Ryota、Ihara Sozaburo、Hikiba Yohko、Kinoshita Hiroto、Higashishima Naoko、Hayakawa Yoku、Yamada Atsuo、Hirata Yoshihiro、Nakata Ryo、Okamoto Makoto、Sano Munetaka、Kushiyama Akifumi、Ichinose Mari、Woods Susan L.、Worthley Daniel、Iwamoto Yasuhiko、Koike Kazuhiko
    • Journal Title

      Cancer Prev Res (Phila)

      Volume: 12 Pages: 185-194

    • DOI

      10.1158/1940-6207.capr-18-0288

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09347, KAKENHI-PROJECT-18K07933, KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-17K15928, KAKENHI-PROJECT-19K17478
  • [Journal Article] Prolyl isomerase Pin1 binds to and stabilizes acetyl CoA carboxylase 1 protein, thereby supporting cancer cell proliferation2019

    • Author(s)
      Ueda Koji、Nakatsu Yusuke、Yamamotoya Takeshi、Ono Hiraku、Inoue Yuki、Inoue Masa-Ki、Mizuno Yu、Matsunaga Yasuka、Kushiyama Akifumi、Sakoda Hideyuki、Fujishiro Midori、Takahashi Shin-Ichiro、Matsubara Akio、Asano Tomoichiro
    • Journal Title

      Oncotarget

      Volume: 10 Pages: 1637-1648

    • DOI

      10.18632/oncotarget.26691

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-16K09761, KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-25221204
  • [Journal Article] Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice:2019

    • Author(s)
      Mizuno Y, Yamamotoya T, Nakatsu Y, Ueda K, Matsunaga Y, Inoue MK, Sakoda H, Fujishiro M, Ono H, Kikuchi T, Takahashi M, Morii K, Sasaki Kg Masaki T, Asano T and Kushiyama A.
    • Journal Title

      Int J Mol Sci,

      Volume: 20 Pages: 1-12

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K02314
  • [Journal Article] Prolyl isomerase Pin1 suppresses thermogenic programs in adipocytes by promoting degradation of transcriptional co-activator PRDM162019

    • Author(s)
      Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue MK, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi SI, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T.
    • Journal Title

      Cell reports

      Volume: 26 Pages: 3221-3230

    • DOI

      10.1016/j.celrep.2019.02.066

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09784, KAKENHI-PROJECT-17K09850, KAKENHI-PROJECT-17K11670, KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-18K17071, KAKENHI-PROJECT-18H03972, KAKENHI-PROJECT-16H05555, KAKENHI-PROJECT-16H06226, KAKENHI-PROJECT-16K09761, KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-16K11503, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-19K17951, KAKENHI-PROJECT-17H01565, KAKENHI-PROJECT-18H02859, KAKENHI-PROJECT-17K11644
  • [Journal Article] Roles of Gut-Derived Secretory Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease and Their Possible Clinical Applications2018

    • Author(s)
      Okubo Hirofumi、Kushiyama Akifumi、Nakatsu Yusuke、Yamamotoya Takeshi、Matsunaga Yasuka、Fujishiro Midori、Sakoda Hideyuki、Ohno Haruya、Yoneda Masayasu、Asano Tomoichiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Pages: 3064-3064

    • DOI

      10.3390/ijms19103064

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-16K09761, KAKENHI-PROJECT-16K09791
  • [Journal Article] The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model2018

    • Author(s)
      Inoue Masa-Ki、Yamamotoya Takeshi、Nakatsu Yusuke、Ueda Koji、Inoue Yuki、Matsunaga Yasuka、Sakoda Hideyuki、Fujishiro Midori、Ono Hiraku、Morii Kenichi、Sasaki Kensuke、Masaki Takao、Suzuki Yusuke、Asano Tomoichiro、Kushiyama Akifumi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Pages: 3967-3967

    • DOI

      10.3390/ijms19123967

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-16K09761, KAKENHI-PROJECT-16K09791
  • [Journal Article] Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages2018

    • Author(s)
      Yamazaki Hiroki、Kushiyama Akifumi、Sakoda Hideyuki、Fujishiro Midori、Yamamotoya Takeshi、Nakatsu Yusuke、Kikuchi Takako、Kaneko Sunao、Tanaka Hirotoshi、Asano Tomoichiro
    • Journal Title

      Mediators of Inflammation

      Volume: 2018 Pages: 1-12

    • DOI

      10.1155/2018/3062319

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18KT0017, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-17K16158, KAKENHI-PROJECT-16H05330, KAKENHI-PROJECT-16K09761, KAKENHI-PROJECT-16K09791
  • [Journal Article] Serum uric acid is an independent predictor of new-onset diabetes after living-donor kidney transplantation2018

    • Author(s)
      Tanaka Kentaro、Sakai Ken、Kushiyama Akifumi、Hara Shigeko、Hattori Masakazu、Ohashi Yasushi、Muramatsu Masaki、Kawamura Takeshi、Shishido Seiichiro、Aikawa Atsushi
    • Journal Title

      Renal Replacement Therapy

      Volume: 4

    • DOI

      10.1186/s41100-018-0169-4

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Journal Article] Development of Pin1 inhibitors and their potential as therapeutic agents2018

    • Author(s)
      Nakatsu Y, Matsunaga Y, Ueda K, Yamamotoya T, Inoue Y, Inoue MK, Mizuno Y, Kushiyama A, Ono H, Fujishiro M, Ito H, Okabe T, Asano T.
    • Journal Title

      Current Medicinal Chemistry

      Volume: - Pages: 1-1

    • DOI

      10.2174/0929867325666181105120911

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09784, KAKENHI-PROJECT-18K08502, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-16K09791
  • [Journal Article] Gut microbiota as a therapeutic target for metabolic disorders2018

    • Author(s)
      Okubo H, Nakatsu Y, Kushiyama A, Yamamotoya T, Matsunaga Y, Inoue MK, Fujishiro M, Sakoda H, Ohno H, Yoneda M, Ono H, Asano T.
    • Journal Title

      Current Medical Chemistry

      Volume: 25 Pages: 984-1001

    • DOI

      10.2174/0929867324666171009121702

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-16J09463, KAKENHI-PROJECT-15K09398, KAKENHI-PROJECT-16K19538, KAKENHI-PROJECT-18K08502
  • [Journal Article] Trk-fused gene regulates pancreatic beta-cell mass and insulin secretory activity.2017

    • Author(s)
      Yamamotoya T, Nakatsu Y, Kushiyama A, Matsunaga Y, Ueda K, Inoue Y, Inoue MK, Sakoda H, Fujishiro M, Ono H, Kiyonari H, Ishihara H, Asano T.
    • Journal Title

      Scientific Report

      Volume: 7 Pages: 1-13

    • DOI

      10.1038/s41598-017-13432-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09761, KAKENHI-PROJECT-16K09784, KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-17K09850, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-16J09463, KAKENHI-PROJECT-15K09398
  • [Journal Article] The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice2017

    • Author(s)
      Yusuke Nakatsu, Hiroki Kokubo, Batmunkh Bumdelger, Masao Yoshizumi, Takeshi Yamamotoya, Yasuka Matsunaga, Koji Ueda, Yuki Inoue, Masa-Ki Inoue, Midori Fujishiro, Akifumi Kushiyama, Hiraku Ono, Hideyuki Sakoda, and Tomoichiro Asano
    • Journal Title

      Int J Mol Sci.

      Volume: 18(8) Pages: 1704-1704

    • DOI

      10.3390/ijms18081704

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08443, KAKENHI-PROJECT-16K09784, KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-16J09463, KAKENHI-PROJECT-15K09398
  • [Journal Article] The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion.2017

    • Author(s)
      Nakatsu Y, Mori K, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mitsuzaki-Miyoshi K, Sakoda H, Fujishiro M, Yamaguchi S, Kushiyama A, Ono H, Ishihara H, Asano T.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 292 Pages: 11886-11895

    • DOI

      10.1074/jbc.m117.780726

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09784, KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-17K09850, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-16J09463, KAKENHI-PROJECT-15K09398
  • [Journal Article] Gastrointestinal symptom prevalence depends on disease duration and gastrointestinal region in type 2 diabetes mellitus.2017

    • Author(s)
      Fujishiro M, Kushiyama A, Yamazaki H, Kaneko S, Koketsu Y, Yamamotoya T, Kikuchi T, Sakoda H, Suzuki R, Kadowaki T
    • Journal Title

      World J Gastroenterol.

      Volume: 23 Pages: 6694-6704

    • DOI

      10.3748/wjg.v23.i36.6694

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09776, KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-17K16150
  • [Journal Article] Epicatechin downregulates adipose tissue CCL19 expression and thereby ameliorates diet-induced obesity and insulin resistance2017

    • Author(s)
      Sano T et al.
    • Journal Title

      Nutrition, metabolism, and cardiovascular diseases

      Volume: 27 Pages: 249-259

    • DOI

      10.1016/j.numecd.2016.11.008

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05555, KAKENHI-PROJECT-16H07067, KAKENHI-PROJECT-26463136, KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-16K11551, KAKENHI-PROJECT-16K11503
  • [Journal Article] Glial fibrillary acidic protein (GFAP) is a novel biomarker for the prediction of autoimmune diabetes.2017

    • Author(s)
      Pang Z, Kushiyama A, Sun J, Kikuchi T, Yamazaki H, Iwamoto Y, Koriyama H, Yoshida S, Shimamura M, Higuchi M, Kawano T, Takami Y, Rakugi H, Morishita R, Nakagami H.
    • Journal Title

      FASEB J.

      Volume: 31 Pages: 4053-4063

    • DOI

      10.1096/fj.201700110r

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Journal Article] Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis2016

    • Author(s)
      Kushiyama A, Nakatsu Y, Matsunaga Y, Yamamotoya T, Mori K, Ueda K, Inoue Y, Sakoda H, Fujishiro M, Ono H, Asano T.
    • Journal Title

      Mediators Inflamm

      Volume: 2016 Pages: 8603164-8603164

    • DOI

      10.1155/2016/8603164

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H06427, KAKENHI-PROJECT-16J09463, KAKENHI-PROJECT-15K09398, KAKENHI-PROJECT-16K09791
  • [Journal Article] C-Peptide Level in Fasting Plasma and Pooled Urine Predicts HbA1c after Hospitalization in Patients with Type 2 Diabetes Mellitus.2016

    • Author(s)
      Sonoda R, Tanaka K, Kikuchi T, Onishi Y, Takao T, Tahara T, Yoshida Y, Suzawa N, Kawazu S, Iwamoto Y, Kushiyama A.
    • Journal Title

      PLoS One

      Volume: 11

    • DOI

      10.1371/journal.pone.0147303

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25461372, KAKENHI-PROJECT-16K09791
  • [Journal Article] Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations2016

    • Author(s)
      Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mori K, Sakoda H, Fujishiro M, Ono H, Kushiyama A, Asano T.
    • Journal Title

      Int J Mol Sci

      Volume: 17 (9) Pages: 1495-1495

    • DOI

      10.3390/ijms17091495

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H06427, KAKENHI-PROJECT-16J09463, KAKENHI-PROJECT-15K09398, KAKENHI-PROJECT-16K09784, KAKENHI-PROJECT-16K09791
  • [Journal Article] Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice.2016

    • Author(s)
      Okubo H, Kushiyama A, Sakoda H, Nakatsu Y, Iizuka M, Taki N, Fujishiro M, Fukushima T, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Asahara T, Yoshida Y, Chonan O, Encinas J, Asano T.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 20157-20157

    • DOI

      10.1038/srep20157

    • NAID

      120006796541

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-25253067, KAKENHI-PROJECT-25461372, KAKENHI-PROJECT-26670447, KAKENHI-PROJECT-26860735, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PROJECT-16H05555, KAKENHI-PROJECT-16K09791
  • [Journal Article] Prediction of the effect on antihyperglycaemic action of sitagliptin by plasma active form glucagon-like peptide-1.2016

    • Author(s)
      Kushiyama A, Kikuchi T, Tanaka K, Tahara T, Takao T, Onishi Y, Yoshida Y, Kawazu S, Iwamoto Y.
    • Journal Title

      World J Diabetes

      Volume: 7 Pages: 230-238

    • DOI

      10.4239/wjd.v7.i11.230

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Journal Article] Prolyl isomerase Pin1 negatively regulates AMP-activated protein kinase (AMPK) by associating with the CBS domain in the γ subunit.2016

    • Author(s)
      Nakatsu Y, Iwashita M, Sakoda H, Ono H, Nagata K, Matsunaga Y, Fukushima T, Fujishiro M, Kushiyama A, Kamata H, Takahashi S, Katagiri H, Honda H, Kiyonari H, Uchida T, Asano T
    • Journal Title

      Journal of Biological Chemistry

      Volume: 290 Pages: 24255-24266

    • DOI

      10.1074/jbc.m115.658559

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09398, KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-26660287, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PROJECT-25253067, KAKENHI-PROJECT-25461372, KAKENHI-PROJECT-26670447, KAKENHI-PROJECT-26252064, KAKENHI-PROJECT-16H05220
  • [Journal Article] Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling.2015

    • Author(s)
      Sano T, Iwashita M, Nagayasu S, Yamashita A, Shinjo T, Hashikata A, Asano T, Kushiyama A, Ishimaru N, Takahama Y, Nishimura F
    • Journal Title

      Obesity (Silver Spring)

      Volume: 23 Pages: 1460-1471

    • DOI

      10.1002/oby.21127

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15676, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111004, KAKENHI-PROJECT-25461372, KAKENHI-PROJECT-26861816, KAKENHI-PROJECT-25293425
  • [Journal Article] Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus.2015

    • Author(s)
      Qiang S, Nakatsu Y, Seno Y, Fujishiro M, Sakoda H, Kushiyama A, Mori K, Matsunaga Y, Yamamotoya T, Kamata H, Asano T.
    • Journal Title

      Diabetol Metab Syndr.

      Volume: 7 Pages: 104-104

    • DOI

      10.1186/s13098-015-0102-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Journal Article] Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model2015

    • Author(s)
      Hirofumi Okubo, Yusuke Nakatsu, Hideyuki Sakoda, Akifumi Kushiyama, Midori Fujishiro, Toshiaki Fukushima, Yasuka Matsunaga, Haruya Ohno, Masayasu Yoneda, Hideaki Kamata, Takanori Shinjo, Misaki Iwashita, Fusanori Nishimura, and Tomoichiro Asano
    • Journal Title

      American Journal Physiolgy-Gastrointestinal and Liver Physiogy

      Volume: 308 Pages: 151-158

    • DOI

      10.1152/ajpgi.00198.2014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-24591314, KAKENHI-PROJECT-24657092, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25461372, KAKENHI-PROJECT-26460369, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406
  • [Journal Article] Role of elevated serum uric acid levels at the onset of overt nephropathy in the risk for renal function decline in patients with type 2 diabetes.2015

    • Author(s)
      Kentaro Tanaka, Shigeko Hara, Masakazu Hattori, Ken Sakai, Yukiko Onishi, Yoko Yoshida, Shoji Kawazu
    • Journal Title

      J Diabetes Investig.

      Volume: - Pages: 98-104

    • DOI

      10.1111/jdi.12243

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Journal Article] The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model2015

    • Author(s)
      Nakatsu Y, Seno Y, Kushiyama A, Sakoda H, Fujishiro M, Katasako A, Mori K, Matsunaga Y, Fukushima T, Kanaoka R, Yamamotoya T, Kamata H, Asano T.
    • Journal Title

      American Journal of Physiology - Gastrointestinal Liver Physiology

      Volume: 309(1)

    • DOI

      10.1152/ajpgi.00443.2014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460369, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PROJECT-25461372
  • [Journal Article] Pin1 inhibitor Juglone exerts anti-oncogenic effects on LNCaP and DU145 cells despite the patterns of gene regulation by Pin1 differing between these cell lines2015

    • Author(s)
      Kanaoka R, Kushiyama A, Seno Y, Nakatsu Y, Matsunaga Y, Fukushima T, Tsuchiya Y, Sakoda H, Fujishiro M, Yamamotoya T, Kamata H, Matsubara A, Asano T.
    • Journal Title

      PLoS ONE

      Volume: 10 (6)

    • DOI

      10.1371/journal.pone.0127467

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10591, KAKENHI-PROJECT-26460369, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PROJECT-25461372
  • [Journal Article] High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice.2015

    • Author(s)
      Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Nishimura F, Asano T.
    • Journal Title

      Diabetol Metab Syndr.

      Volume: 7 Pages: 50-50

    • DOI

      10.1186/s13098-015-0047-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15351, KAKENHI-PROJECT-25461372
  • [Journal Article] LUBAC formation is impaired in the livers of mice with MCD-dependent non-alcoholic steatohepatitis2015

    • Author(s)
      Matsunaga Y, Nakatsu Y, Fukushima T, Okubo H, Iwashita M, Sakoda H, Fujishiro M, Yamamotoya T, Kushiyama A, Takahashi S, Tsuchiya Y, Kamata H, Tokunaga F, Iwai K, Asano T.
    • Journal Title

      Mediators of Inflammation

      Volume: 2015 Pages: 10-10

    • DOI

      10.1155/2015/125380

    • NAID

      120005745641

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08259, KAKENHI-PROJECT-26460369, KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-25461372, KAKENHI-PROJECT-26670154, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-25253019
  • [Journal Article] Lactobacillus casei strain Shirota protects against non-alcoholic steatohepatitis development in a rodent model.2015

    • Author(s)
      Okubo H, Sakoda H, Kushiyama A, Fujishiro M, Nakatsu Y, Fukushima T, Matsunaga Y, Kamata H, Asahara T, Yoshida Y, Chonan O, Iwashita M, Nishimura F, Asano T
    • Journal Title

      American Journal of Physiology –Gastrointestinal and Liver Physiology

      Volume: 305 Pages: 911-918

    • DOI

      10.1152/ajpgi.00225.2013

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20117012, KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-24591314, KAKENHI-PROJECT-24591315, KAKENHI-PROJECT-24657092, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25461372
  • [Journal Article] DPP-4 inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation2015

    • Author(s)
      Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Nishimura F, Asano T.
    • Journal Title

      American Journal of Physiology - Endocrinology and Metabolism

      Volume: 309(3)

    • DOI

      10.1152/ajpendo.00553.2014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460369, KAKENHI-PROJECT-15K15351, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PROJECT-25461372
  • [Journal Article] Linking uric acid metabolism to diabetic complications.2014

    • Author(s)
      Kushiyama A, Tanaka K, Hara S, Kawazu S.
    • Journal Title

      World J Diabetes

      Volume: 15 Pages: 787-795

    • DOI

      10.4239/wjd.v5.i6.787

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Journal Article] 尿酸代謝と生活習慣病の新知見2014

    • Author(s)
      櫛山 暁史
    • Journal Title

      生体の科学

      Volume: 65 Pages: 11-11

    • Data Source
      KAKENHI-PROJECT-25461372
  • [Journal Article] The inflammation-lipocalin 2 axis may contribute to the development of chronic kidney disease.2014

    • Author(s)
      Hashikata A, Yamashita A, Suzuki S, Nagayasu S, Shinjo T, Taniguchi A, Fukushima M, Nakai Y, Nin K, Watanabe N, Asano T, Abiko Y, Kushiyama A, Nagasaka S, Nishimura F.
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 29 Pages: 611-618

    • DOI

      10.1093/ndt/gft449

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25293425, KAKENHI-PROJECT-25461372
  • [Journal Article] A 20-year trend of increasing obesity in young patients with poorly controlled type 2 diabetes at first diagnosis in urban Japan2013

    • Author(s)
      Kushiyama A
    • Journal Title

      J Diabet Invest.

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791047
  • [Journal Article] Resistin-like molecule β is abundantly expressed in foam cells and is involved in atherosclerosis development2013

    • Author(s)
      Kushiyama A
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791047
  • [Journal Article] Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice2013

    • Author(s)
      Iwashita M, Nakatsu Y, Sakoda H, Fujishiro M, Kushiyama A, Fukushima T, Kumamoto S, Shinjo T, Kamata H, Nishimura F, Asano T
    • Journal Title

      adipocyte

      Volume: 2(1) Pages: 28-32

    • DOI

      10.4161/adip.21837

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-24591314, KAKENHI-PROJECT-24792328
  • [Journal Article] Twenty-year trend of increasing obesity in young patients with poorly controlled type 2 diabetes at first diagnosis in urban Japan.2013

    • Author(s)
      Kushiyama A, Yoshida Y, Kikuchi T, Suzawa N, Yamamoto M, Tanaka K, Okayasu M, Tahara T, Takao T, Onishi Y, Kawazu S.
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 4 Pages: 540-545

    • DOI

      10.1111/jdi.12090

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Journal Article] Integrator complex plays an essential role in adipose differentiation2013

    • Author(s)
      Otani Y, Nakatsu Y, Sakoda H, Fukushima T, Fujishiro M, Kushiyama A, Okubo H, Tsuchiya Y, Ohno H, Takahashi S, Nishimura F, Kamata H, Katagiri H, Asano T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 434 Pages: 0-0

    • DOI

      10.1016/j.bbrc.2013.03.029

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20117012, KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-24591314, KAKENHI-PROJECT-24591315, KAKENHI-PROJECT-24657092, KAKENHI-PROJECT-24790928
  • [Journal Article] Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.2013

    • Author(s)
      Zhang J, Nakatsu Y, Sinjo T, Guo Y, Sakoda H, Yamamotoya T, Otani Y, Okubo H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Nishimura F, Katagiri H, Takahashi SI, Kurihara H, Uchida T, Asano T.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 288 Pages: 20692-20701

    • DOI

      10.1074/jbc.m113.485730

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20117012, KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-24591314, KAKENHI-PROJECT-24591315, KAKENHI-PROJECT-24657092, KAKENHI-PROJECT-24790928, KAKENHI-PROJECT-25461372
  • [Journal Article] Resistin-like molecule β is abundantly expressed in foam cells and is involved in atherosclerosis development2013

    • Author(s)
      Kushiyama A, Sakoda H, Oue N, Okubo M, Nakatsu Y, Ono H, Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 33 Pages: 1986-1992

    • DOI

      10.1161/atvbaha.113.301546

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-20117012, KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-23591099, KAKENHI-PROJECT-23659107, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-24249047, KAKENHI-PROJECT-24591314, KAKENHI-PROJECT-24591315, KAKENHI-PROJECT-24657092, KAKENHI-PROJECT-24790928, KAKENHI-PUBLICLY-25111705, KAKENHI-PROJECT-25460416, KAKENHI-PROJECT-25461372, KAKENHI-PROJECT-25670762
  • [Journal Article] Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation : potential link with metabolic complications2012

    • Author(s)
      Nakarai, H, Yamashita, A, Nagayasu, S, Iwashita, M, Kumamoto, S, Ohyama, H, Hata, M, Soga, Y, Kushiyama, A, Asano, T, Abiko, Y, Nishimura, F
    • Journal Title

      Innate Immun

      Volume: 18 Pages: 164-170

    • DOI

      10.1177/1753425910393370

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390497, KAKENHI-PROJECT-21390556, KAKENHI-PROJECT-23593076, KAKENHI-PROJECT-23791047
  • [Journal Article] Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development2012

    • Author(s)
      Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 32 Pages: 291-298

    • DOI

      10.1161/atvbaha.111.234559

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390238, KAKENHI-PROJECT-21390556, KAKENHI-PROJECT-22780249, KAKENHI-PROJECT-22790847, KAKENHI-PUBLICLY-23013007, KAKENHI-PROJECT-23659107, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-24249047, KAKENHI-PROJECT-24790928
  • [Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in co-cultured adipocytes2012

    • Author(s)
      Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T.
    • Journal Title

      American Journal Physiology Endocrinology and Metabolism

      Volume: 302 Pages: 286-296

    • DOI

      10.1152/ajpendo.00324.2011

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20117012, KAKENHI-PROJECT-21390556, KAKENHI-PROJECT-22780249, KAKENHI-PROJECT-22790847, KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-23390213, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-23870022, KAKENHI-PROJECT-24790928
  • [Journal Article] Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model.2012

    • Author(s)
      Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Kikuchi T, Fukushima T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi SI, Kurihara H, Uchida T, Asano T
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 44526-35

    • DOI

      10.1074/jbc.m112.397133

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390556, KAKENHI-PUBLICLY-23013007, KAKENHI-PROJECT-23370062, KAKENHI-PROJECT-23659107, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-23870022, KAKENHI-PROJECT-24249047, KAKENHI-PROJECT-24591314, KAKENHI-PROJECT-24591315, KAKENHI-PROJECT-24790928
  • [Journal Article] Atrio-His (James) accessory pathway and infiltration of γδ T cells in the heart with MELAS2011

    • Author(s)
      Matsuzaki G, Kushiyama A, Uto K, Shoda M, Seko Y
    • Journal Title

      BMJ Case Rep

    • DOI

      10.1136/bcr.09.2010.3359

    • Data Source
      KAKENHI-PROJECT-23791047
  • [Journal Article] Peptidyl-proiyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis2011

    • Author(s)
      Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi SI, Kurihara H, Uchida T, Asano T
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 286 Pages: 20812-2022

    • DOI

      10.1074/jbc.m110.206904

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390556, KAKENHI-PLANNED-22126006, KAKENHI-PROJECT-22248030, KAKENHI-PROJECT-22780249, KAKENHI-PROJECT-22790847, KAKENHI-PROJECT-22790869, KAKENHI-PROJECT-23390238, KAKENHI-PROJECT-23791047, KAKENHI-PROJECT-23870022
  • [Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity.2011

    • Author(s)
      Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T
    • Journal Title

      American Journal of Physiology-Cell Physiology

      Volume: 300(5) Pages: 1047-54

    • DOI

      10.1152/ajpcell.00416.2010

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22126006, KAKENHI-PROJECT-22780249, KAKENHI-PROJECT-22790847, KAKENHI-PROJECT-22790869, KAKENHI-PROJECT-23390238, KAKENHI-PROJECT-23791047
  • [Journal Article] Risk of macrovascular disease stratified by stage of chronic kidney disease in type 2 diabetic patients: critical level of the estimated glomerular filtration rate and the significance of hyperuricemia.2011

    • Author(s)
      Tanaka K, Hara S, Kushiyama A, Ubara Y, Yoshida Y, Mizuiri S, Aikawa A, Kawatzu S
    • Journal Title

      Clin Exp Nephrol

      Volume: 15(3) Pages: 391-397

    • DOI

      10.1007/s10157-011-0420-6

    • NAID

      10029005803

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23791047
  • [Journal Article] Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy.2010

    • Author(s)
      櫛山暁史
    • Journal Title

      Diabetes Research and Clinical Practice 87

      Pages: 57-63

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790756
  • [Journal Article] Regulation of gut-derived resistin-like molecule beta expression by nutrients2008

    • Author(s)
      Fujio J, 櫛山 暁史, 他
    • Journal Title

      Diabetes Research and Clinical Practice 79

      Pages: 2-10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790644
  • [Journal Article] Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice.2008

    • Author(s)
      Koketsu Y, Sakoda H, Fujishiro M, Kushiyama A, Fukushima Y, Ono H, Anai M, Kikuchi T, Fukuda T, Kamata H, Horike N, Uchijima Y, Kurihara H, Asano T
    • Journal Title

      Am J Physiol Endocrinol Metab 294(4)

    • Data Source
      KAKENHI-PROJECT-19790644
  • [Journal Article] AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptionaI activity and phosphoenolpyruvate carboxykinase C gene expression in the liver.2008

    • Author(s)
      Horike N, 櫛山暁史, 他
    • Journal Title

      J Biol Chem 283

      Pages: 33902-10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790644
  • [Journal Article] Regulation of gut-derived resistin-like molecule beta expression by nutrients.2008

    • Author(s)
      Fujio J, Kushiyama A, Sakoda H, Fujishiro M, Ogihara T, Fukushima Y, Anai M, Horike N, Kamata H, Uchijima Y, Kurihara H, Asano T
    • Journal Title

      Diabetes Res Clin Pract 79(1)

      Pages: 2-10

    • Data Source
      KAKENHI-PROJECT-19790644
  • [Journal Article] Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice.2008

    • Author(s)
      Koketsu N, 櫛山暁史, 他
    • Journal Title

      Am J Physiol Endocrinol Metab. 294

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790644
  • [Journal Article] AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver.2008

    • Author(s)
      Horike N, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Kamata H, Nishiyama K, Uchijima Y, Kurihara Y, Kurihara H, Asano T
    • Journal Title

      J Biol Chem. 283(49)

      Pages: 33902-10

    • Data Source
      KAKENHI-PROJECT-19790644
  • [Journal Article] Long-term forskolin stimulation induces AMPK activation and thereby enhances tight junction formation in human placental trophoblast BeWo cells.2008

    • Author(s)
      Egawa M, Kamata H, Kushiyama A, Sakoda H, Fujishiro M, Horike N, Yoneda M, Nakatsu Y, Ying G, Jun Z, Tsuchiya Y, Takata K, Kurihara H, Asano T
    • Journal Title

      Placenta 29(12)

      Pages: 1003-8

    • Data Source
      KAKENHI-PROJECT-19790644
  • [Journal Article] Long-term forskolin stimulation induces AMPK activation and thereby enhances tight junction formation in human placental trophoblast BeWo cells.2008

    • Author(s)
      Egawa M, 櫛山暁史, 他
    • Journal Title

      Placenta 29

      Pages: 1003-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790644
  • [Journal Article] Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways.2007

    • Author(s)
      Ono H, Sakoda H, Fujishiro M, Anai M, Kushiyama A, Fukushima Y, Katagiri H, Ogihara T, Oka Y, Kamata H, Horike N, Uchijima Y, Kurihara H, Asano T
    • Journal Title

      Am J Physiol Cell Physiol 293(5)

    • Data Source
      KAKENHI-PROJECT-19790644
  • [Journal Article] Role of phosphatidylinositol 3-kinase activation on insulin action and its alteration in diabetic conditions.2007

    • Author(s)
      Asano T, Fujishiro M, Kushiyama A, Nakatsu Y, Yoneda M, Kamata H, Sakoda H
    • Journal Title

      Biol Pharm Bull 30(9)

      Pages: 1610-6

    • NAID

      110006380237

    • Data Source
      KAKENHI-PROJECT-19790644
  • [Journal Article] Physiological significance of resistin and resistin-like molecules in the inflammatory process and insulin resistance.2006

    • Author(s)
      Asano T, Sakoda H, Fujishiro M, Anai M, Kushiyama A, Horike N, Kamata H, Ogihara T, Kurihara H, Uchijima Y
    • Journal Title

      Curr Diabetes Rev. 2(4)

      Pages: 449-54

    • Data Source
      KAKENHI-PROJECT-19790644
  • [Patent] ワクチン、医薬及び糖尿病合併症治療薬2021

    • Inventor(s)
      櫛山暁史ほか
    • Industrial Property Rights Holder
      櫛山暁史ほか
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-031201
    • Filing Date
      2021
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Patent] 大腸癌、動脈硬化症又はメタボリックシンドロームの検出法2013

    • Inventor(s)
      櫛山暁史
    • Industrial Property Rights Holder
      櫛山暁史
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-02-28
    • Data Source
      KAKENHI-PROJECT-23791047
  • [Patent] 大腸癌、動脈硬化症、又はメタボリックシンドロームの検出方法2013

    • Inventor(s)
      浅野 知一郎、櫛山 暁史
    • Industrial Property Rights Holder
      広島大学・朝日生命成人病研究所
    • Acquisition Date
      2013-03-29
    • Data Source
      KAKENHI-PROJECT-23791047
  • [Patent] 大腸癌、動脈硬化症、又はメタボリックシンドロームの検出方法2012

    • Inventor(s)
      浅野 知一郎、櫛山 暁史
    • Industrial Property Rights Holder
      広島大学・朝日生命成人病研究所
    • Industrial Property Number
      2013-040964
    • Filing Date
      2012-11-26
    • Data Source
      KAKENHI-PROJECT-23791047
  • [Patent] 大腸癌、動脈硬化症、又はメタボリックシンドロームの検出方法2007

    • Inventor(s)
      櫛山暁史・浅野知一郎
    • Industrial Property Rights Holder
      櫛山暁史・浅野知一郎
    • Filing Date
      2007-12-12
    • Data Source
      KAKENHI-PROJECT-19790644
  • [Patent] 大腸癌、動脈硬化症、又はメタボリックシンドロームの検出方法2007

    • Inventor(s)
      櫛山暁史, 他1名
    • Industrial Property Rights Holder
      櫛山暁史, 他1名
    • Filing Date
      2007-12-12
    • Data Source
      KAKENHI-PROJECT-21790756
  • [Patent] 大腸癌、動脈硬化症、又はメタボリックシンドロームの検出方法2007

    • Inventor(s)
      浅野 知一郎、櫛山 暁史
    • Industrial Property Rights Holder
      浅野 知一郎、櫛山 暁史
    • Filing Date
      2007-12-12
    • Data Source
      KAKENHI-PROJECT-19790644
  • [Presentation] 脂肪細胞のTrk-fused gene(TFG)はPPARγ発現量およびミトコンドリア機能を調節し,adipose expansionに重要である2021

    • Author(s)
      山本屋 武 長谷井 竣 中津 祐介 迫田 秀之 藤城 緑 櫛山 暁史 浅野 知一郎
    • Organizer
      第63回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Presentation] Luseogliflozinの治療におけるQOLの変化に関する検討(ルセフィQOL研究)第2報2021

    • Author(s)
      櫛山暁史 朝長 修 五十川 陽洋 西村 秀樹 長坂 昌一郎 加藤 光敏 折笠 秀樹 岩本 安彦
    • Organizer
      第63回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Presentation] 2型糖尿病を対象としたプリン体代謝関連物質の血管合併症発症および進展に対する影響の研究(続報)2021

    • Author(s)
      藤城 緑 櫛山 暁史 小川 克彦 渡邉 健太郎 江頭 富士子 岡本 真由美 村瀬 貴代 中村 敬志 赤利 精悟 迫田 秀之 小野 啓 山本屋 武 中津 祐介 浅野 知一郎 石原 寿光
    • Organizer
      第63回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Presentation] 代謝に依存した生活習慣病における血管障害2021

    • Author(s)
      櫛山暁史
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Presentation] 非LDLの血管障害リスク~血糖・尿酸など~2019

    • Author(s)
      櫛山 暁史
    • Organizer
      第27回血管生物医学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Presentation] 都市部における2型糖尿病患者の初診時臨床像の変遷2019

    • Author(s)
      吉田洋子、櫛山暁史、髙尾淑子、大西由希子、田原たづ、菊池貴子、高橋和之、震明あすか、春日雅人
    • Organizer
      第62回糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Presentation] Relationship between plaque destabilization and glucose / nucleic acid metabolism.2019

    • Author(s)
      Kushiyama A, Takahashi M, Nakagami H
    • Organizer
      Inaugural Joint Scientific Meeting of AVBS/ANZMS/AAVBM
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Presentation] SGLT2阻害薬によるマウス糖尿病性腎障害の改善及び,腎Pin1発現量の是正とAMPK活性化の関与2019

    • Author(s)
      井上賢紀、中津祐介、松永泰花、山本屋 武、上田晃嗣、井上由貴、水野 優、櫛山暁史、浅野知一郎
    • Organizer
      第62回糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Presentation] キサンチンオキシダーゼ阻害薬febuxostatによる糖尿病性腎症の改善とその機序の解明2019

    • Author(s)
      水野 優、中津祐介、山本屋 武、上田晃嗣、井上賢紀、藤城 緑、 迫田秀之、櫛山暁史、浅野知一郎
    • Organizer
      第62回糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Presentation] 2型糖尿病を対象としたプリン体代謝関連物質の血管合併症発症および進展に対する影響の研究2019

    • Author(s)
      藤城 緑、櫛山暁史、小川克彦、山口 賢、渡邉健太郎、村瀬貴代、中村敬志、赤利精悟、山本屋 武、中津祐介、浅野知一郎、石原寿光
    • Organizer
      第62回糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Presentation] 糖尿病の病態における尿酸代謝の役割2019

    • Author(s)
      櫛山暁史
    • Organizer
      第52回日本痛風・核酸代謝学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] 肥満症の成人に対する短期間の厳密な低糖質食(糖質50gまたは120g)介入による前向き研究結果2019

    • Author(s)
      菊池貴子、櫛山暁史、春日雅人
    • Organizer
      第62回糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Presentation] Novel therapeutics for diabetic retinopathy:2019

    • Author(s)
      Kushiyama A
    • Organizer
      Symposium on Interdisciplinary Approach for the Development of Novel Diagnosis and Treatment of Retinal Diseases
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Presentation] Pin1 and Trk-fused gene(TFG):novel regulators for β-cell mass and function2019

    • Author(s)
      山本屋 武、中津祐介、櫛山暁史、石原寿光、浅野知一郎
    • Organizer
      第62回糖尿病学会年次学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Presentation] 尿酸と尿酸産生の血管疾患マーカーとしての役割2019

    • Author(s)
      櫛山暁史
    • Organizer
      第83回日本循環器学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] Luseogliflozinの治療におけるQOLの変化に関する検討(ルセフィQOL研究)2019

    • Author(s)
      櫛山暁史、朝長 修、五十川陽洋、西村秀樹、長坂昌一郎、加藤光敏、折笠秀樹、岩本安彦
    • Organizer
      第62回糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-19K11784
  • [Presentation] Role of xanthine oxidoreductase from mesenchymal cells in retinal inflammation after pericyte breakdown2018

    • Author(s)
      AKIFUMI KUSHIYAMA, TAKAKO KIKUCHI, HIROKI YAMAZAKI, TAKESHI YAMAMOTOYA, HIDEYUKI SAKODA, MIDORI FUJISHIRO, YUSUKE NAKATSU, AKIYOSHI UEMURA, TAKASHI SHIRAKURA, TOMOICHIRO ASANO, YASUHIKO IWAMOTO
    • Organizer
      ADA American Diabetes Association 78th Scientific Sessions
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] マクロファージ由来キサンチン酸化還元酵素の代謝・熱産生への関与2018

    • Author(s)
      櫛山 暁史, 菊池 貴子, 藤城 緑, 迫田 秀之, 中村 敬志, 村瀬 貴代, 松永 泰花, 山本屋 武, 中津 祐介, 浅野 知一郎, 岩本 安彦
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] Xanthine Oxidoreductaseの組織特異的発現による代謝制御2018

    • Author(s)
      櫛山暁史、菊池貴子、村瀬貴代、世良康如、藤城緑、山本屋武、中津祐介、中村敬志、本田浩章、春日雅人、浅野知一郎
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] ペリサイト障害モデルにおける血管透過性に対するキサンチンオキシダーゼの役割2018

    • Author(s)
      櫛山暁史、菊池貴子、植村明嘉、福嶋葉子、櫛山櫻、浅野知一郎
    • Organizer
      日本血管生物医学会
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] ビグアナイド系薬剤服用患者の アドヒアランスに関する要因2018

    • Author(s)
      谷口洸亮、櫛山暁史、末永みどり、庄野あい子、菊池 貴子、岩本 安彦、赤沢学
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] Role of uric acid metabolism in pathogenesis of diabetes mellitus2018

    • Author(s)
      AKIFUMI KUSHIYAMA
    • Organizer
      3rd EAGER Meeting
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] 妊娠中毒症を伴う妊娠および出産と 2 型糖尿病発症の関連2018

    • Author(s)
      末永 みどり, 櫛山 暁史, 庄野 あい子, 赤沢 学
    • Organizer
      日本薬学会 第138年会
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] 2型糖尿病を対象としたキサンチン酸化還元酵素の血管合併症発症および進展に対する影響に関する探索研究2018

    • Author(s)
      藤城 緑、櫛山 暁史、山口 賢、渡邉 健太郎、江頭 富士子、岡本 真由美、村瀬 貴代、中村 敬志、山本屋 武、中津 祐介、浅野 知一郎 、石原 寿光
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] 糖尿病専門医による 2 型糖尿病患者の処方変更の実態2017

    • Author(s)
      仙石 悠紀子, 米川 拓渡, 櫛山 暁史, 山崎 広貴, 菊池 貴子, 庄野 あい子, 金井 紀仁, 赤沢 学
    • Organizer
      日本薬学会第137年会
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] Inhibition of diabetic retinopathy by xanthine oxidase inhibitor2017

    • Author(s)
      櫛山 暁史, 菊池 貴子, 植村 明嘉, 福嶋 葉子,櫛山 櫻, 岩本 安彦, 浅野 知一郎
    • Organizer
      Molecular Cardiovascular Metabolic Conference
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] 安全かつ効果的に結果にコミットできる減量方法の確立を目指して2017

    • Author(s)
      櫛山暁史
    • Organizer
      第38回日本肥満学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] ペリサイト障害モデルにおける網膜浮腫に対するキサンチンオキシダーゼ阻害の効果2017

    • Author(s)
      櫛山 暁史, 菊池 貴子, 植村 明嘉, 福嶋 葉子,櫛山 櫻, 岩本 安彦, 浅野 知一郎
    • Organizer
      第25回日本血管生物医学会学術集会(CVMW2017)
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] Molecular mechanism of retinal edema by xanthine oxidase inhibitor2017

    • Author(s)
      櫛山 暁史, 菊池 貴子, 植村 明嘉, 福嶋 葉子,櫛山 櫻, 岩本 安彦, 浅野 知一郎
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBIo2017)
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] 糖尿病専門医院における患者背景のデータベース構築2017

    • Author(s)
      米川拓渡, 沖村悠希, 梶山里奈, 小泉聖人,仙石悠紀子,宮下紗季,森田修司,金井紀仁,櫛山暁史,山崎広貴,菊池貴子, 赤沢学
    • Organizer
      日本薬学会第137年会
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] 組織特異的キサンチンオキシダーゼによるインスリン感受性と慢性炎 症の制御2017

    • Author(s)
      櫛山 暁史, 菊池 貴子, 植村 明嘉, 福嶋 葉子,櫛山 櫻, 岩本 安彦, 浅野 知一郎
    • Organizer
      第60回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] Inhibition of endothelial sprouting by the xanthine oxidase inhibitor2016

    • Author(s)
      Akifumi Kushiyama, Takako Kikuchi, Hiroki Yamazaki, Sakura Kushiyama, Yasuhiko Iwamoto, Tomoichiro Asano
    • Organizer
      第24回日本血管生物医学会学術集会
    • Place of Presentation
      長崎ブリックホール(長崎)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] 2型糖尿病患者男女における骨密度及び海綿骨スコアの変化2016

    • Author(s)
      櫛山暁史、山崎広貴、藤田政子、菊池貴子、田原たづ、大西由希子、高尾淑子、吉田洋子、岩本安彦、板橋明
    • Organizer
      第18回 骨粗しょう症学会
    • Place of Presentation
      仙台 勝山館(宮城)
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] Anti-angiogenic effect of xanthine oxidase inhibition on endothelial cells2016

    • Author(s)
      Akifumi Kushiyama, Takako Kikuchi, Hiroki Yamazaki, Yoko Fukushima, Akiyoshi Uemura, Yuichiro Arima, Koichi Nishiyama, Sakura Kushiyama, Yasuhiko Iwamoto, Tomoichiro Asano
    • Organizer
      IVBM2016
    • Place of Presentation
      Sheraton Boston Hotel (USA)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] 組織特異的キサンチン酸化還元酵素のインスリン抵抗性に果たす役割2016

    • Author(s)
      櫛山暁史、菊池貴子、山崎広貴、藤田政子、嶋崎喜代子、櫛山櫻、浅野知一郎、西山功一、有馬勇一郎、栗原裕基
    • Organizer
      MCCII
    • Place of Presentation
      東京ドームホテル(東京)
    • Year and Date
      2016-09-02
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] 医療機関での取り組み -初診時療養指導と受診中断者への働きがけによる受診中断対策2016

    • Author(s)
      吉田洋子  櫛山暁史  岩本安彦
    • Organizer
      第59回 日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] 血管新生におけるキサンチンオキシダーゼ阻害の血管内皮細胞への影響 Effect of xanthine oxidase inhibitor on endothelial cells during angiogenesis2016

    • Author(s)
      櫛山暁史、菊池貴子、山崎広貴、福嶋葉子、植村明嘉、 西山功一、有馬勇一郎、櫛山櫻、岩本安彦、浅野知一郎
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] 糖尿病患者に対するMCG解析2016

    • Author(s)
      櫛山暁史
    • Organizer
      第57回 日本人間ドック学会学術大会
    • Place of Presentation
      まつもと市民芸術館(長野)
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] 肝外キサンチンオキシダーゼのインスリン抵抗性への関与2016

    • Author(s)
      櫛山暁史、菊池貴子、迫田秀之、藤城緑、山崎広貴、山本屋武、大久保博史、中津祐介、河津捷二、岩本安彦、浅野知一郎
    • Organizer
      第59回 日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Data Source
      KAKENHI-PROJECT-16K09791
  • [Presentation] フルクトースの誘導する炎症におけるマクロファージ由来キサンチン酸化還元酵素の役割2015

    • Author(s)
      櫛山 暁史
    • Organizer
      第6回Molecular Cardiovascular Conference II
    • Place of Presentation
      兵庫県
    • Year and Date
      2015-09-04
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Presentation] マクロファージにおける糖代謝による活性酸素産生とインスリン抵抗性2015

    • Author(s)
      櫛山暁史、菊池貴子、迫田秀之、藤城緑、山崎広貴、山本屋武、大久保博史、中津祐介、河津捷二、岩本安彦、浅野知一郎
    • Organizer
      第58回日本糖尿病学会学術集会
    • Place of Presentation
      山口県
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Presentation] 尿酸代謝と粥状動脈硬化 ・高すぎる尿酸値と低すぎる尿酸値の動脈硬化リスク2015

    • Author(s)
      櫛山 暁史
    • Organizer
      第47回 動脈硬化学会学術集会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2015-07-09
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Presentation] Novel insights into anti-diabetic effects of sex hormone binding globulin (SHBG): anti-inflammatory actions on both adipocytes and macrophages2015

    • Author(s)
      H Yamazaki, A Kushiyama, H Sakoda, M Fujishiro, T Asano
    • Organizer
      Diabetes: New Insights into Molecular Mechanisms and Therapeutic Strategies Keystone Symposia on Molecular and Cellular Biology
    • Place of Presentation
      京都府
    • Year and Date
      2015-10-25
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Presentation] Extrahepatic xanthine oxidoreductase as a therapeutic target for diabetes mellitus and its complications2015

    • Author(s)
      A Kushiyama, T Kikuchi, H Yamazaki, H Sakoda, Y Iwamoto, T Asano
    • Organizer
      Diabetes: New Insights into Molecular Mechanisms and Therapeutic Strategies Keystone Symposia on Molecular and Cellular Biology
    • Place of Presentation
      京都府
    • Year and Date
      2015-10-25
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Presentation] Multifunctional Cardiography(MCG)を用いた2型糖尿病患者の心筋虚血の検出2013

    • Author(s)
      常田智子,福井美弥子,新井 恵,難波敏子,宮城よう子,吉川美帆,山本美津代,板橋 明,田原たづ,吉田洋子,河津捷二,櫛山暁史
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本県
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Presentation] Involvement of macrophage-derived resistin like molecule β in atherosclerosis development2013

    • Author(s)
      A. Kushiyama, T. Kikuchi, H. Sakoda, M. Fujishiro, K. Nishiyama, H. Kurihara, Y. Higashi, S. Kawazu, T. Asano
    • Organizer
      第45回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      東京都
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Presentation] 空腹時活性化GLP-1によるDPP4阻害薬シタグリプチンの効果予測2013

    • Author(s)
      櫛山暁史,菊池貴子,大西由希子,田原たづ,髙尾淑子,山本万友美,須澤直木,吉田洋子,河津捷二
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本県
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Presentation] 食事成分が誘引となる血管障害2013

    • Author(s)
      櫛山暁史,菊池貴子,櫛山 櫻,浅野知一郎,西山功一,栗原裕基
    • Organizer
      第4回 Molecular Cardiovascular Conference II
    • Place of Presentation
      北海道
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Presentation] インスリン抵抗性および大血管障害における マクロファージ由来resistin like molecule βの意義2012

    • Author(s)
      櫛山暁史
    • Organizer
      第24回分子糖尿病学シンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23791047
  • [Presentation] A 20-year trend of patients with type 2 diabetes at first diagnosis in urban Japan2012

    • Author(s)
      櫛山暁史
    • Organizer
      2012 IDF-WPR AASD
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23791047
  • [Presentation] インスリン分泌能と関連する 血糖変動指標の特徴2012

    • Author(s)
      櫛山暁史
    • Organizer
      第55回日本糖尿病学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23791047
  • [Presentation] Mechanism of atherosclerosis development facilitated by resistin like molecule beta2011

    • Author(s)
      櫛山 暁史
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県 神戸市)
    • Data Source
      KAKENHI-PROJECT-23791047
  • [Presentation] 2型糖尿病患者における骨折リスクに関する横断的研究2011

    • Author(s)
      櫛山 暁史
    • Organizer
      第13回骨粗鬆症学会 健診・骨ドック分科会
    • Place of Presentation
      神戸国際会議場(兵庫県 神戸市)
    • Data Source
      KAKENHI-PROJECT-23791047
  • [Presentation] キサンチンオキシダーゼ経路のマクロファージ泡沫化と動脈硬化への関与(一般口演)2011

    • Author(s)
      櫛山 暁史
    • Organizer
      第54回日本糖尿病学会学術総会
    • Place of Presentation
      札幌プリンスホテル(北海道 札幌市)
    • Data Source
      KAKENHI-PROJECT-23791047
  • [Presentation] マクロファージから分泌されるレジスチン様分子β(RELMβ)の生理的意義とインスリン抵抗性の発症機序2010

    • Author(s)
      櫛山暁史, 迫田秀之, 菊池貴子, 大西由希子, 佃克則, 藤城緑, 纐纈優子, 櫛山櫻, 佐藤博和, 菊池方利, 大野晴也, 大久保博史, 張君, 郭瑩, 中津祐介, 河津捷二, 浅野知一郎
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2010-05-29
    • Data Source
      KAKENHI-PROJECT-21790756
  • [Presentation] マクロファージから分泌されるレジスチン様分子β(RELMβ)の生理的意義とインスリン抵抗性の発症機序2010

    • Author(s)
      櫛山暁史, 迫田秀之, 菊池貴子, 大西由希子, 佃克則, 藤城緑, 纐纈優子, 櫛山櫻, 佐藤博和, 菊池方利, 大野晴也, 大久保博史, 張君, 郭瑩, 中津祐介, 河津捷二, 浅野知一郎
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山県
    • Data Source
      KAKENHI-PROJECT-21790756
  • [Presentation] インスリン抵抗性を誘導するレジスチンファミリー分子(resistin, RELMβ)の動脈硬化への独立した役割の解析2009

    • Author(s)
      櫛山暁史, 迫田秀之, 藤城緑, 纐纈優子, 菊池貴子, 大西由希子, 佃克則, 佐藤博和, A.Viana, 高城直幸, 飯塚正樹, 櫛山櫻, 油谷浩幸, 栗原裕基, 菊池方利, 浅野知一郎
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪府
    • Data Source
      KAKENHI-PROJECT-21790756
  • [Presentation] 腸管およびマクロファージに由来するレジスチン様分子βは動脈硬化・インスリン抵抗性の進展及び発がんに関与する2009

    • Author(s)
      櫛山暁史
    • Organizer
      分子生物学会2009
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-10
    • Data Source
      KAKENHI-PROJECT-21790756
  • [Presentation] 腸管およびマクロファージに由来するレジスチン様分子βは動脈硬化・インスリン抵抗性の進展及び発がんに関与する2009

    • Author(s)
      櫛山暁史, 菊池貴子, 大西由希子, 佃克則, 河津捷二, 佐藤博和, 迫田秀之, 藤城緑, 纐纈優子, 仙谷和弘, 大上直秀, 石垣泰, 片桐秀樹, 浅野知一郎
    • Organizer
      分子生物学会
    • Place of Presentation
      神奈川県
    • Year and Date
      2009-12-10
    • Data Source
      KAKENHI-PROJECT-21790756
  • [Presentation] インスリン抵抗性を誘導するレジスチンファミリー分子(resistin、RELMβ)の動脈硬化への独立した役割の解析2009

    • Author(s)
      櫛山暁史
    • Organizer
      第52回日本糖尿病学会学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2009-05-24
    • Data Source
      KAKENHI-PROJECT-21790756
  • [Presentation] Functionally distinct roles of each member of the resistin family in insulin resistance and atherosclerosis2008

    • Author(s)
      櫛山 暁史, 他
    • Organizer
      68^<th> ADA scientific session
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2008-06-08
    • Data Source
      KAKENHI-PROJECT-19790644
  • [Presentation] インスリン抵抗性を誘導するレジスチンファミリー(resistin/RELMβ)は各々異なった機序で動脈硬化に関与する2008

    • Author(s)
      櫛山暁史, 浅野知一郎, 迫田秀之, 藤城緑, 纐纈優子, 福田武俊, 佃克則, 大西由希子, Amelia, 犬飼浩一, 菊池方利
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京都
    • Data Source
      KAKENHI-PROJECT-19790644
  • [Presentation] インスリン抵抗性を誘導するレジスチンファミリー(resistin/RELMβ)は各々異なった機序で動脈硬化に関与する2008

    • Author(s)
      櫛山 暁史, 他
    • Organizer
      第51回日本糖尿病学会学術総会
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-05-24
    • Data Source
      KAKENHI-PROJECT-19790644
  • [Presentation] Functionally distinct roles of each member of the resistin family in insulin resistance and atherosclerosis2008

    • Author(s)
      A. Kushiyama, H. Sakoda, M. Fujishiro, H. Ohno, M. Yoneda, Y. Nakatsu, H. Kamata, M. Kikuchi, T. Asano
    • Organizer
      68th American Diabetes Association Scientific Sessions
    • Place of Presentation
      San Francisco, USA
    • Data Source
      KAKENHI-PROJECT-19790644
  • [Presentation] Resistin-like molecule(RELM)βは内皮機能障害及び炎症反応を介して動脈硬化に関与する2007

    • Author(s)
      櫛山暁史, 浅野知一郎, 迫田秀之, 藤城緑, 纐纈優子, 穴井元暢, 油谷浩幸, 栗原裕基, 菊池方利
    • Organizer
      BMB2007
    • Place of Presentation
      神奈川県
    • Year and Date
      2007-12-13
    • Data Source
      KAKENHI-PROJECT-19790644
  • [Presentation] 腸管由来RELM(resistin like molecules)βは動脈硬化・メタボリック症候群に関与する2007

    • Author(s)
      櫛山 暁史, 他
    • Organizer
      第50回日本糖尿病学会学術総会
    • Place of Presentation
      Sendai
    • Year and Date
      2007-05-26
    • Data Source
      KAKENHI-PROJECT-19790644
  • [Presentation] Resistin like molecule beta induces atherosclerosis via directly impairing vascular endothelial function and priming inflammation as a mediator of immune-response2007

    • Author(s)
      櫛山 暁史, 他
    • Organizer
      BMB2007
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-12-13
    • Data Source
      KAKENHI-PROJECT-19790644
  • [Presentation] Increased RELMβ expression in saturated fatty acid-treated colonic cells: possible involvement of toll-like receptors2007

    • Author(s)
      A. Y. I VIANA, 櫛山 暁史, 他
    • Organizer
      13th international congress of immunology
    • Place of Presentation
      Rio de Janeiro
    • Year and Date
      2007-08-21
    • Data Source
      KAKENHI-PROJECT-19790644
  • [Presentation] Involvement of Resistin-like molecule β in the development of non-alcoholic steatohepatitis

    • Author(s)
      Akifumi Kushiyama, Hirofumi Okubo, Yusuke Nakatsu, Hideyuki Sakoda, Midori Fujishiro, Toshiaki Fukushima, Shin-ichiro Takahashi, Tomoichiro Asano
    • Organizer
      第74回米国糖尿病学会議
    • Place of Presentation
      米国サンフランシスコ
    • Year and Date
      2014-06-13 – 2014-06-17
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Presentation] マクロファージresistin like moleculeβによるインスリン抵抗性・動脈硬化発症の機序

    • Author(s)
      櫛山暁史 菊池貴子、迫田秀之、藤城緑、山崎広貴、山本屋武、大久保博史、中津祐介、河津捷二、浅野知一郎
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Presentation] 食事成分に起因する組織特異的キサンチン酸化還元酵素を介した核酸代謝と酸化ストレス

    • Author(s)
      櫛山暁史、菊池貴子、藤田政子、櫛山櫻、浅野知一郎、西山功一、栗原裕基
    • Organizer
      第5回MCC(Molecular Cardiovascular Conference) II
    • Place of Presentation
      大阪
    • Year and Date
      2014-09-04 – 2014-09-05
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Presentation] resistin like moleculeβを介した マクロファージ分化と炎症

    • Author(s)
      櫛山暁史 菊池貴子、迫田秀之、藤城緑、山崎広貴、山本屋武、大久保博史、中津祐介、河津捷二、浅野知一郎
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      宮崎
    • Year and Date
      2014-10-24 – 2014-10-25
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Presentation] キサンチンオキシダーゼ阻害剤FebuxostatによるNASH改善作用の検討

    • Author(s)
      藤城緑、中津祐介、福嶋俊明、松永泰花、迫田秀之、櫛山暁史、山本屋武、西村英紀、浅野知一郎
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Presentation] Macrophage resistin-like molecule β is involved in atherosclerosis development.

    • Author(s)
      Akifumi Kushiyama, Takako Kikuchi, Hideyuki Sakoda, Koichi Nishiyama, Hiroki Kurihara, Tomoichiro Asano, Shoji Kawazu
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      京都
    • Year and Date
      2014-04-14 – 2014-04-17
    • Data Source
      KAKENHI-PROJECT-25461372
  • [Presentation] 糖代謝に伴う核酸代謝由来酸化ストレスと臓器障害

    • Author(s)
      櫛山 暁史、櫛山 櫻、菊池 貴子、栗原 裕基、浅野 知一郎、河津 捷二
    • Organizer
      第37回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-25461372
  • 1.  ASANO Tomoichiro (70242063)
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  • 2.  SAKODA Hideyuki (50376464)
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  • 4.  南 道子 (70272432)
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  • 5.  YAMASHITA Akiko
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  • 6.  NAKATSU Yusuke
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  • 7.  ONO Hiraku
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  • 8.  YOSHIZUMI Masao
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  • 9.  TSUCHIYA Yoshihiro
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  • 10.  SUZUKI Ryo
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  • 11.  Kadowaki Takashi
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  • 12.  SANUI Terukazu
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  • 13.  SUZUKI Shigeki
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  • 14.  Fukushima Toshiaki
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  • 15.  AKAZAWA Hiroshi
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  • 16.  UCHIDA Chiyoko
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  • 17.  NISHIYAMA Koichi
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  • 18.  SENTANI Kazuhiro
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  • 19.  石丸 直澄
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  • 20.  高浜 洋介
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  • 21.  岩下 未咲
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  • 22.  西村 英紀
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  • 23.  石原 寿光
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  • 24.  藤城 緑
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  • 25.  山本屋 武
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  • 26.  安孫子 宜光
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  • 27.  小久保 博樹
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  • 28.  片桐 秀樹
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  • 30.  田中 廣壽
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  • 34.  栗原 由紀子
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  • 35.  兼松 隆
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  • 37.  徳永 文稔
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  • 39.  高橋 伸一郎
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  • 40.  長町 安希子
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  • 41.  大久保 博史
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  • 42.  早河 翼
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  • 43.  山田 篤生
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  • 44.  新倉 量太
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  • 45.  鈴木 伸三
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  • 46.  内田 隆史
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  • 47.  東 幸仁
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  • 48.  山脇 洋輔
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  • 49.  大野 晴也
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  • 50.  高橋 圭
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  • 51.  山田 哲也
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