Akasaka Eijiro 赤坂英二郎

… Alternative Names

AKASAKA Eijiro 赤坂英二郎

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Researcher Number	30436034
Other IDs
Affiliation (Current)	2025: 弘前大学, 医学研究科, 教授
Affiliation (based on the past Project Information) *help	2023: 弘前大学, 医学研究科, 教授 2020 – 2022: 弘前大学, 医学部附属病院, 助教 2012 – 2017: 弘前大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Dermatology / Basic Section 53050:Dermatology-related Except Principal Investigator Dermatology / Basic Section 53050:Dermatology-related
Keywords	Principal Investigator 表皮水疱症 / VII型コラーゲン / 栄養障害型表皮水疱症 / 掌蹠角化症 / 活性酸素 / トロンボスポンディン-1 / インテグリン / マトリックスメタロプロテイナーゼ / 線維化 / TGF-beta … More / TAT / チロシンアミノトランスフェラーゼ / Richner-Hanhart症候群 / 高チロシン血症 / 痒疹型 / 栄養障害型 / COL7A1 / ケラチン６ｃ / ケラチン6c / 変異 / 遺伝子 / ケラチン6C … More Except Principal Investigator 皮膚 / ヘム生合成系 / コプロポルフィリノーゲン酸化酵素 / 遺伝性コプロポルフィリン症 / ポルフィリン症 / 末梢血白血球 / Ⅶ型コラーゲン / 間葉系幹細胞 / VII型コラーゲン / 末梢血単核細胞 / 治療 / 角化 / 遺伝病 / 遺伝子 / ラジカル / スピンラベル / 角質間脂質 / 角化症 Less

遺伝性ポルフィリン症におけるヘム生合成に関する新規代謝経路の解明
- Principal Investigator
  
  中野創
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Hirosaki University
TGF-beta Signaling in fibrosis of recessive dystrophic epidermolysis bullosaPrincipal Investigator
- Principal Investigator
  
  Akasaka Eijiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Hirosaki University
Richner-Hanhart症候群の高チロシン血症に伴う掌蹠過角化の発症機構Principal Investigator
- Principal Investigator
  
  赤坂英二郎
- Project Period (FY)
  2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Hirosaki University
COL7A1 expression in the peripheral blood mononuclear cells
- Principal Investigator
  
  NAKANO Hajime
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Hirosaki University
Is there any responsible genetic factor other than mutation of COL7A1 underlying pathogenesis of dystrophic epidermolysis bullosa?Principal Investigator
- Principal Investigator
  
  EIJIRO AKASAKA
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Hirosaki University
The elucidation of mechanism of hyperkeratosis and development of protein replacement therapy in patients with Mal de Meleda.
- Principal Investigator
  
  Nakajima Koji
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Hirosaki University
Mutational analysis of palmoplantar keratoderma caused by keratin 6c mutationPrincipal Investigator
- Principal Investigator
  
  AKASAKA Eijiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Hirosaki University
Establishment of method using spin labeling that evaluates function and structure of lipids between corneal layers.
- Principal Investigator
  
  SAWAMURA Daisuke
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Hirosaki University

All 2023 2022 2021 2020 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] A case of adult‐onset localized recessive dystrophic epidermolysis bullosa, harboring the novel COL7A1 mutation p.G2754E and the previously reported mutation p.R1763*2023
- Author(s)
  Akasaka Eijiro、Rokunohe Daiki、Nakano Hajime、Yamatani Shingo、Sawamura Daisuke
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 51 Issue: 3
- DOI
  10.1111/1346-8138.16993
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08646
[Journal Article] Two cases of the intermediate phenotype of recessive dystrophic epidermolysis bullosa harboring the novel COL7A1 mutation c.3570G>A2022
- Author(s)
  Akasaka Eijiro、Nakano Hajime、Sawamura Daisuke
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 106 Issue: 3 Pages: 193-195
- DOI
  10.1016/j.jdermsci.2022.04.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08646
[Journal Article] Availability of mRNA Obtained from Peripheral Blood Mononuclear Cells for Testing Mutation Consequences in Dystrophic Epidermolysis Bullosa2021
- Author(s)
  Akasaka E, Nakano H, Sawamura D
- Journal Title
  
  International Journal of Molecular Science
  
  Volume: 22 Issue: 24 Pages: 13369-13369
- DOI
  10.3390/ijms222413369
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08646
[Journal Article] Diversity of Mechanisms Underlying Latent TGF-b Activation in Recessive Dystrophic Epidermolysis Bullosa2020
- Author(s)
  Akasaka E, Kleiser S, Sengle G, Bruckner-Tuderman L, Nystrom A
- Journal Title
  
  Journal of Investigative Dermatolgoy
  
  Volume: - Issue: 6 Pages: 1450-1460
- DOI
  10.1016/j.jid.2020.10.024
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08646
[Journal Article] The first case of multiple pilomatricomas caused by somatic mutations of CTNNB1 without any associated disorder.2017
- Author(s)
  Akasaka E, Nakano H, Fukui T, Korekawa A, Aizu T, Sawamura D
- Journal Title
  
  J Dermatol Sci
  
  Volume: 88 Issue: 2 Pages: 259-260
- DOI
  10.1016/j.jdermsci.2017.06.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09739, KAKENHI-PROJECT-17K10225
[Journal Article] Multiple milia as an isolated skin manifestation of dominant dystrophic epidermolysis bullosa: Evidence of phenotypic variability.2017
- Author(s)
  Akasaka E, Nakano H, Takagi Y, Toyomaki Y, Sawamura D
- Journal Title
  
  Pediatr Dermatol
  
  Volume: 34 Issue: 2
- DOI
  10.1111/pde.13047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19670, KAKENHI-PROJECT-26293254, KAKENHI-PROJECT-15K09739, KAKENHI-PROJECT-17K10225, KAKENHI-PROJECT-26461653, KAKENHI-PROJECT-16K15541
[Journal Article] Squamous cell carcinoma on the lip arising from discoid lupus erythematosus: a case report and review of Japanese patients.2016
- Author(s)
  Makita E, Akasaka A, Sakuraba Y, Korekawa A, Aizu T, Kaneko T, Nakano H, Sawamura D
- Journal Title
  
  Eur J Dermatol
  
  Volume: 26 Issue: 4 Pages: 395-396
- DOI
  10.1684/ejd.2016.2780
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19670, KAKENHI-PROJECT-26461674
[Journal Article] Amelanotic acral lentiginous melanoma mimicking diabetic ulcer: a challenge to diagnose and treat.2016
- Author(s)
  Kaneko T, Korekawa A, Akasaka E, Nakano H, Sawamura D
- Journal Title
  
  Eur J Dermatol
  
  Volume: 26 Issue: 1 Pages: 107-108
- DOI
  10.1684/ejd.2015.2695
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461674, KAKENHI-PROJECT-15K19670
[Journal Article] 【似たもの同士:目で見る鑑別診断2016-水疱性病変編】 (Part4.)下肢(case 14)　優性栄養障害型表皮水疱症(痒疹型)vs結節性痒疹(解説/特集).2016
- Author(s)
  赤坂英二郎、滝吉典子、中野　創、澤村大輔
- Journal Title
  
  Visual Dermatology
  
  Volume: 15 Pages: 715-717
- Data Source
  KAKENHI-PROJECT-15K19670
[Journal Article] 優性栄養障害型表皮水疱症（痒疹型）VS結節性痒疹.2016
- Author(s)
  赤坂英二郎、滝吉典子、中野　創、澤村大輔
- Journal Title
  
  Visual Dermatol
  
  Volume: 15 Pages: 715-717
- Data Source
  KAKENHI-PROJECT-15K09739
[Journal Article] Elevated levels of circulating immunoglobulin E autoantibodies against BP180 and BP230 in an intractable case of bullous pemphigoid.2016
- Author(s)
  Akasaka E, Hagiwara C, Takiyoshi N, Aizu T, Nakano H, Sawamura D, Ota T
- Journal Title
  
  J Dermatol Sci
  
  Volume: 84 Pages: 110-113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19670
[Journal Article] Rubinstein-Taybi syndrome with multiple pilomatricomas: The first case diagnosed by CREBBP mutation analysis.2016
- Author(s)
  Rokunohe D, Nakano H, Akasaka E, Toyomaki Y, Sawamura D
- Journal Title
  
  J Dermatol Sci
  
  Volume: 83 Issue: 3 Pages: 240-242
- DOI
  10.1016/j.jdermsci.2016.06.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19670
[Journal Article] X-linked dominant protoporphyria: The first reported Japanese case.2016
- Author(s)
  Ninomiya Y, Kokunai Y, Tanizaki H, Akasaka E, Nakano H, Moriwaki S.
- Journal Title
  
  Journal of Dermatology
  
  Volume: 43 Issue: 4 Pages: 414-8
- DOI
  10.1111/1346-8138.13101
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19670, KAKENHI-PROJECT-15K09739
[Journal Article] Mycosis fungoides bullosa associated with bullous pemphigoid.2015
- Author(s)
  Korekawa A, Kaneko T, Nakajima K, Rokunohe D, Akasaka E, Nakano H, Sawamura D, Fukui T, Takiyoshi N, Kitamura H, Harada K
- Journal Title
  
  Int J Dermatol
  
  Volume: 54 Issue: 9
- DOI
  10.1111/ijd.12821
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461674, KAKENHI-PROJECT-15K19670, KAKENHI-PROJECT-25860928, KAKENHI-PROJECT-26293254
[Journal Article] Elderly-Onset Generalized Pustular Psoriasis without a Previous History of Psoriasis Vulgaris.2015
- Author(s)
  Aizu T, Matsui A, Takiyoshi N, Akasaka E, Kaneko T, Nakano H, Sugiura K, Akiyama M, Sawamura D
- Journal Title
  
  Case Rep Dermatol
  
  Volume: 7 Issue: 2 Pages: 187-193
- DOI
  10.1159/000438505
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461674, KAKENHI-PROJECT-15K15414, KAKENHI-PROJECT-15K19670, KAKENHI-PROJECT-26670526, KAKENHI-PROJECT-26860864
[Journal Article] Anti-laminin γ1 pemphigoid associated with ulcerative colitis and psoriasis vulgaris showing autoantibodies to laminin γ1, type XVII collagen and laminin-332.2015
- Author(s)
  Akasaka E, Nakano H, Korekawa A, Fukui T, Kaneko T, Koga H, Hashimoto T, Sawamura D.
- Journal Title
  
  Eur J Dermatol
  
  Volume: 26 Issue: 2 Pages: 198-199
- DOI
  10.1684/ejd.2014.2499
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670497, KAKENHI-PROJECT-25860929, KAKENHI-PROJECT-26293254, KAKENHI-PROJECT-26461674, KAKENHI-PROJECT-15K19670
[Journal Article] Diaminodiphenyl Sulfone-Induced Hemolytic Anemia and Alopecia in a Case of Linear IgA Bullous Dermatosis.2015
- Author(s)
  Akasaka E, Kayo SJ, Nakano H, Ishii N, Hashimoto T, Sawamura D.
- Journal Title
  
  Case Reports in Dermatology
  
  Volume: 7 Issue: 2 Pages: 183-6
- DOI
  10.1159/000438506
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19670, KAKENHI-PROJECT-26293254
[Journal Article] Two Japanese familial cases of punctate palmoplantar keratoderma caused by a novel AAGAB mutation, c.191_194delCAAA.2015
- Author(s)
  Akasaka E, Okawa Y, Nakano H, Takiyoshi N, Rokunohe D, Toyomaki Y, Sawamura D, Sueki H.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 78 Issue: 2 Pages: 156-158
- DOI
  10.1016/j.jdermsci.2015.02.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670497, KAKENHI-PROJECT-25860929, KAKENHI-PROJECT-26293254, KAKENHI-PROJECT-26860865, KAKENHI-PROJECT-26461653, KAKENHI-PROJECT-15K19670
[Journal Article] Primary Amelanotic Rhabdoid Melanoma: A Case Report with Review of the Literature.2015
- Author(s)
  Kaneko T, Korekawa A, Akasaka E, Rokunohe D, Nakano H, Sawamura D
- Journal Title
  
  Case Rep Dermatol
  
  Volume: 7 Issue: 3 Pages: 292-297
- DOI
  10.1159/000441347
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461674, KAKENHI-PROJECT-15K19670, KAKENHI-PROJECT-26860865
[Journal Article] Superficial epidermolytic ichthyosis caused by a novel KRT2 mutation.2015
- Author(s)
  Akasaka E, Minakawa S, Rokunohe D, Toyomaki Y, Matsuzaki Y, Sawamura D, Nakano H
- Journal Title
  
  J Dermatol Sci.
  
  Volume: 79 Issue: 1 Pages: 182-184
- DOI
  10.1016/j.jdermsci.2015.04.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09739, KAKENHI-PROJECT-26461675, KAKENHI-PROJECT-15K19670, KAKENHI-PROJECT-26860864
[Journal Article] Case of oculocutaneous albinism complicated with squamous cell carcinoma, Bowen's disease and actinic keratosis.2014
- Author(s)
  Minakawa S, Kaneko T, Matsuzaki Y, Akasaka E, Mizukami H, Abe Y, Hozumi Y,
- Journal Title
  
  J Dermatol．
  
  Volume: 41 Issue: 9 Pages: 863-864
- DOI
  10.1111/1346-8138.12597
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670497, KAKENHI-PROJECT-25860929, KAKENHI-PROJECT-26461674, KAKENHI-PROJECT-26461675, KAKENHI-PROJECT-26860864
[Journal Article] Mutational analysis on 16 Japanese population cases with epidermolysis bullosasimplex2013
- Author(s)
  Minakawa S, Nakano H, Nakajima K, Matsuzaki Y, Takiyoshi N, Akasaka E, Rokunohe D, Sawamura D
- Journal Title
  
  J Dermatol Sci
  
  Volume: 72(3) Issue: 3 Pages: 330-332
- DOI
  10.1016/j.jdermsci.2013.08.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390279, KAKENHI-PROJECT-23591611, KAKENHI-PROJECT-24791131, KAKENHI-PROJECT-25860929
[Journal Article] A Case of Erythema Nodosum Associated with Subareolar Abscess.2012
- Author(s)
  Minakawa S
- Journal Title
  
  Journal of Cosmetics, Dermatological Sciences and Applications
  
  Volume: 2 Issue: 04 Pages: 263-264
- DOI
  10.4236/jcdsa.2012.24049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591610, KAKENHI-PROJECT-23791248, KAKENHI-PROJECT-24659518, KAKENHI-PROJECT-24791131
[Journal Article] Multiple aplasia cutis congenita lesions located along Blaschko's lines in a patient with tetralogy of Fallot-A.2012
- Author(s)
  Rokunohe D
- Journal Title
  
  J Dermatol Case Rep
  
  Volume: 6 Issue: 2 Pages: 40-42
- DOI
  10.3315/jdcr.2012.1096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591610, KAKENHI-PROJECT-23591611, KAKENHI-PROJECT-23791248, KAKENHI-PROJECT-24591621, KAKENHI-PROJECT-24659518
[Presentation] 栄養障害型表皮水疱症における TGF-βシグナル活性化メカニズムの解明2023
- Author(s)
  赤坂　英二郎
- Organizer
  第10回皮膚の会.
- Data Source
  KAKENHI-PROJECT-20K08646
[Presentation] 口腔癌を合併したKindler症候群の1例2023
- Author(s)
  赤坂英二郎, 中野創, 澤村大輔
- Organizer
  第43回水疱症研究会
- Data Source
  KAKENHI-PROJECT-20K08646
[Presentation] 遺伝性水疱症の診断とその対応2023
- Author(s)
  赤坂　英二郎
- Organizer
  第123回日本皮膚科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08646
[Presentation] Usefulness of mRNA Obtained from Peripheral Blood Mononuclear Cells to Analyze Consequences of Mutations in Epidermolysis Bullosa2022
- Author(s)
  Eijiro Akasaka
- Organizer
  The 47th Annual Meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08646
[Presentation] Availability of mRNA Obtained from Peripheral Blood Mononuclear Cells for Mutational Analysis in Dystrophic Epidermolysis Bullosa2022
- Author(s)
  Eijiro Akasaka
- Organizer
  The 51st Annual Meeting of the European Society for Dermatological Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08646
[Presentation] 栄養障害型表皮水疱症における TGF-βシグナリング活性化機構2021
- Author(s)
  赤坂　英二郎, Alexander Nystrom, Leena Bruckner-Tuderman, 澤村　大輔
- Organizer
  第42回水疱症研究会
- Data Source
  KAKENHI-PROJECT-20K08646
[Presentation] Diversity of Mechanisms Underlying Dysregulating TGF-β Signaling in Recessive Dystrophic Epidermolysis Bullosa2021
- Author(s)
  Akasaka E, Bruckner-Tuderman L, Nystrom A, Nakano H, Sawamura D
- Organizer
  The 46th Annual Meeting of the Japanese Society for Investigative Dermatolgy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08646
[Presentation] Epidermal keratinocytes are involved in severe skin fibrosis of recessive dystrophic epidermolysis bullsoa2020
- Author(s)
  Akasaka E, Bruckner-Tuderman L, Nystrom A
- Organizer
  第34回表皮細胞研究会
- Data Source
  KAKENHI-PROJECT-20K08646
[Presentation] ケラチン6a遺伝子にN172del変異を同定した先天性爪甲硬厚症の孤発例2017
- Author(s)
  赤坂英二郎、中野　創、馬場由香、澤村大輔
- Organizer
  日本皮膚科学会第79回沖縄地方会
- Place of Presentation
  沖縄県医師会館（沖縄県・南風原町）
- Year and Date
  2017-01-29
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] 末梢血間葉系幹細胞におけるⅦ型コラーゲン発現について2017
- Author(s)
  赤坂英二郎、中野　創、神田由紀、鷹木由里子、豊巻由香、澤村大輔
- Organizer
  第24回分子皮膚科学フォーラム
- Data Source
  KAKENHI-PROJECT-26461653
[Presentation] Serum levels of thymus and activation-regulated chemokine can be a useful marker for pruritus of healthy individuals2017
- Author(s)
  Eijiro Akasaka, Kenji Hara, Mika Takahashi, Tomohisa Fukui, Ayumi Korekawa, Hajime Nakano, Ippei Takahashi, Shigeyuki Nakaji, Daisuke Sawamura
- Organizer
  42nd Annual Meeting of the Japanese Society of Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10225
[Presentation] Elevated serum IgE level, but not TARC and LDH, may reflect the impairment of stratum corneum barrier function in healthy individuals; Results of cross-sectional study of 1141 Japanese healthy individuals2017
- Author(s)
  Eijiro Akasaka, Kenji Hara, Mika Takahashi, Tomohisa Fukui, Ayumi Korekawa, Hajime Nakano, Ippei Takahashi, Shigeyuki Nakaji, Daisuke Sawamura
- Organizer
  76th Annual Meeting of Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10225
[Presentation] Nagashima-type palmoplantar keratoderma: A possible soil of melanoma.2017
- Author(s)
  Korekawa A, Akasaka E, Rokunohe D, Fukui T, Makita E, Sawamura D, Sawamura D
- Organizer
  第31回表皮細胞研究会
- Data Source
  KAKENHI-PROJECT-26461653
[Presentation] Peripheral blood mononuclear cells may contain a small amount of mesenchymal stem cells which express type VII collagen.2017
- Author(s)
  Eijiro Akasaka, Hajime Nakano, Daisuke Sawamura
- Organizer
  17th World Dermatology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10225
[Presentation] Elevated serum IgE level, but not TARC and Eosinophil counts, may reflect the impairment of stratum corneum barrier function in healthy indivisuals; Results of cross-sectional study of 1137 Japanese healthy individuals.2017
- Author(s)
  Akasaka E, Hara K, Takahashi M, Fukui T, Korekawa A, Nakano H, Takahashi I, Nakaji S, Sawamura D
- Organizer
  76th Annual SID Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09739
[Presentation] Mutational analysis of Porphyria in Japan2017
- Author(s)
  Eijiro Akasaka, Hajime Nakano, Daisuke Sawamura
- Organizer
  8th Asia and Oceania Conference on Photobiology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10225
[Presentation] 末梢血間葉系幹細胞におけるⅦ型コラーゲン発現について2017
- Author(s)
  赤坂英二郎、中野　創、神田由紀、鷹木由里子、豊巻由香、澤村大輔
- Organizer
  第24回分子皮膚科学フォーラム
- Data Source
  KAKENHI-PROJECT-15K09739
[Presentation] X連鎖性魚鱗癬の遺伝子診断について2017
- Author(s)
  赤坂英二郎、中野　創、河野通浩、秋山真志、澤村大輔
- Organizer
  第32回角化症研究会
- Data Source
  KAKENHI-PROJECT-26461653
[Presentation] ステロイドパルス両方に抵抗性を示し柴苓湯が奏功した後天性特発性全身性無汗症.2017
- Author(s)
  赤坂英二郎、原　憲司、神　可代、中島康爾、会津隆幸、中野　創、澤村大輔
- Organizer
  第4回汗と皮膚疾患の研究会
- Data Source
  KAKENHI-PROJECT-15K09739
[Presentation] X連鎖性魚鱗癬の遺伝子診断について2017
- Author(s)
  赤坂英二郎、中野　創、河野通浩、秋山真志、澤村大輔
- Organizer
  第32回角化症研究会
- Data Source
  KAKENHI-PROJECT-15K09739
[Presentation] 末梢血単核球由来mRNAを用いたCOL7A1変異検索の有用性について2016
- Author(s)
  赤坂英二郎、中野　創、神田由起、鷹木由里子、豊巻由香、澤村大
- Organizer
  日本皮膚科学会青森地方会第376回例会
- Place of Presentation
  ホテル青森（青森県・青森市）
- Year and Date
  2016-12-04
- Data Source
  KAKENHI-PROJECT-15K09739
[Presentation] 長島型掌蹠角化症との鑑別を要したPapillon-Lefèvre症候群2016
- Author(s)
  赤坂英二郎、中野　創、三澤　恵、清水忠道、澤村大輔
- Organizer
  第31回角化症研究会
- Place of Presentation
  海運クラブ（東京都・千代田区）
- Year and Date
  2016-07-30
- Data Source
  KAKENHI-PROJECT-26461653
[Presentation] 栄養障害型表皮水疱症の遺伝子診断における末梢血単核球のⅦ型コラーゲン発現についての検討2016
- Author(s)
  赤坂英二郎、中野　創、神田由起、鷹木由里子、豊巻由香、澤村大輔
- Organizer
  第38回水疱症研究会
- Place of Presentation
  ラフレさいたま（埼玉県・さいたま市）
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] Mutational analysis of dystrophic epidermolysis bullosa2016
- Author(s)
  Akasaka　E, Nakano　H, Sawamura　D
- Organizer
  13th International Congress of Human Genetics
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2016-04-03
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] 長島型掌蹠角化症との鑑別を要したPapillon-Lefèvre症候群2016
- Author(s)
  赤坂英二郎、中野　創、三澤　恵、清水忠道、澤村大輔
- Organizer
  第31回回角化症研究会
- Place of Presentation
  海運クラブ（東京都・千代田区）
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] 栄養障害型表皮水疱症における末梢血単核球から分離したmRNAを用いたCOL7A1変異検索.2016
- Author(s)
  赤坂英二郎、中野　創、神田由紀、鷹木由里子、豊巻由香、澤村大輔
- Organizer
  第23回分子皮膚科学フォーラム
- Place of Presentation
  ホテルグランヴィア大阪（大阪府・大阪市）
- Year and Date
  2016-04-15
- Data Source
  KAKENHI-PROJECT-15K09739
[Presentation] Relationship between stratum corneum barrier function and itch; Results of cross-sectional study of 1141 healthy volunteers2016
- Author(s)
  赤坂英二郎、原　憲司、高橋実か、福井智久、是川あゆ美、中野　創、高橋一平、中路重之、澤村大輔
- Organizer
  第30回表皮細胞研究会
- Place of Presentation
  アートホテル弘前シティ（青森県・弘前市）
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] Mutational analysis of dystrophic epidermolysis bullosa.2016
- Author(s)
  Akasaka　E, Nakano　H, Sawamura　D
- Organizer
  The 13th International Congress of Human Genetics
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2016-04-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09739
[Presentation] 栄養障害型表皮水疱症の遺伝子診断における末梢血単核球のⅦ型コラーゲン発現についての検討2016
- Author(s)
  赤坂英二郎、中野　創、神田由起、鷹木由里子、豊巻由香、澤村大輔
- Organizer
  第38回水疱症研究会
- Place of Presentation
  ラフレさいたま（埼玉県・さいたま市）
- Year and Date
  2016-11-29
- Data Source
  KAKENHI-PROJECT-15K09739
[Presentation] UROD遺伝子変異が同定された晩発性皮膚ポリフィリン症2016
- Author(s)
  松井彰伸、赤坂英二郎、鷹木由里子、豊巻由香、神田由起、今　敦、原田　研、澤村大輔、中野　創
- Organizer
  第38回日本光医学・光生物学会
- Place of Presentation
  京都リサーチパークサイエンスホール（京都府・京都市）
- Year and Date
  2016-07-22
- Data Source
  KAKENHI-PROJECT-15K09739
[Presentation] Richner-Hanhart症候群(高チロシン血症II型)の1例2016
- Author(s)
  赤坂英二郎，滝吉典子，松﨑康司，櫻庭裕祐，是川あゆ美，会津隆幸，豊巻由香，中野　創，澤村大輔
- Organizer
  第373回日本皮膚科学会岩手地方会
- Place of Presentation
  マリオス（岩手県盛岡市）
- Year and Date
  2016-02-06
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] 稗粒腫を初発症状とし家系内で異なる臨床病型を呈した優性栄養障害型表皮水疱症の1家系例2016
- Author(s)
  赤坂英二郎、中野　創、鷹木由里子、豊巻由香、澤村大輔
- Organizer
  第115回日本皮膚科学会総会
- Place of Presentation
  .国立京都国際会館・グランドプリンスホテル京都.（京都府・京都市）
- Year and Date
  2016-06-03
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] 栄養障害型表皮水疱症における末梢血単核球から分離したmRNAを用いたCOL7A1変異検索2016
- Author(s)
  赤坂英二郎、中野　創、神田由紀、鷹木由里子、豊巻由香、澤村大輔
- Organizer
  第23回分子皮膚科学フォーラム
- Place of Presentation
  ホテルグランヴィア大阪（大阪府・大阪市）
- Year and Date
  2016-04-15
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] 多発性毛母腫を契機に診断が確定した筋強直性ジストロフィーの1家系例2016
- Author(s)
  赤坂英二郎、中野　創、豊巻由香、澤村大輔
- Organizer
  日本皮膚科学会青森地方会第375回例会
- Place of Presentation
  ホテルニューキャッスル（青森県・弘前市）
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] Detection of circulating IgE autoantibody to BP180 and its possible correlation with disease severity for urticarial erythema2015
- Author(s)
  Eijiro Akasaka, Chihiro Kinjo, Noriko Takiyoshi, Takayuki Aizu, Yuki Kanda, Yuka Toyomaki, Hajime Nakano, Daisuke Sawamura
- Organizer
  40th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  Okayama Convention Center（Okayama）
- Year and Date
  2015-12-11
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] Beta-catenin mutational analysis in multiple pilomatricomas2015
- Author(s)
  赤坂英二郎、中野　創、櫻庭裕祐、高橋育子、豊巻由香、澤村大輔
- Organizer
  第22回分子皮膚科学フォーラム
- Place of Presentation
  ホテル日航高知旭ロイヤル（高知県高知市）
- Year and Date
  2015-04-17
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] 当科における掌蹠角化症の遺伝子変異検索2015
- Author(s)
  赤坂英二郎，中野　創，鷹木由里子，豊巻由香，澤村大輔
- Organizer
  日本皮膚科学会青森地方会第371回例会
- Place of Presentation
  ホテルナクアシティ弘前（青森県弘前市）
- Year and Date
  2015-08-30
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] 多発性毛母腫におけるベータカテニン遺伝子変異の検討2015
- Author(s)
  赤坂英二郎、中野　創、櫻庭裕祐、高橋育子、豊巻由香、澤村大輔
- Organizer
  第114回日本皮膚科学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] FECH遺伝子にp.Ile186Thr変異を有した骨髄性プロトポルフィリン症2015
- Author(s)
  赤坂英二郎，鷹木由里子，澤村大輔，中野　創
- Organizer
  第37回日本光医学・光生物学会
- Place of Presentation
  シーガイアコンベンションセンター（宮崎県宮崎市）
- Year and Date
  2015-07-17
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] 著明な好酸球増多と浮腫性紅斑を示し血漿交換が奏功した水疱性類天疱瘡2015
- Author(s)
  赤坂英二郎、金城千尋、会津隆幸、中野　創、澤村大輔
- Organizer
  第37回水疱症研究会
- Place of Presentation
  コラッセふくしま（福島県福島市）
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] Richner-Hanhart症候群の遺伝子診断2015
- Author(s)
  赤坂英二郎、中野　創、滝吉典子、豊巻由香、澤村大輔
- Organizer
  第29回表皮細胞研究会
- Place of Presentation
  ホテルニューオータニ佐賀（佐賀県佐賀市）
- Year and Date
  2015-11-14
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] フェロケラターゼ遺伝子のIVS3-48C/C遺伝子多型と軽症型骨髄性プロトポルフィリン症2015
- Author(s)
  赤坂英二郎，鷹木由里子，澤村大輔，川田　暁，錦織千佳子，上出良一，清水忠道，中野　創
- Organizer
  第4回光皮膚科学研究会
- Place of Presentation
  新大阪ワシントンホテルプラザ（大阪府大阪市）
- Year and Date
  2015-05-16
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] 当科における掌蹠角化症の遺伝子変異検索2015
- Author(s)
  赤坂英二郎、中野　創、鷹木由里子、豊巻由香、澤村大輔
- Organizer
  日本皮膚科学会青森地方会第371回例会
- Place of Presentation
  ホテルナクアシティ弘前（青森県弘前市）
- Year and Date
  2015-08-30
- Data Source
  KAKENHI-PROJECT-26461653
[Presentation] 新規ケラチン2遺伝子変異により生じた表在性表皮融解性魚鱗癬2015
- Author(s)
  赤坂英二郎，中野　創，皆川智子，六戸大樹，豊巻由香，松﨑康司，澤村大輔
- Organizer
  第30回角化症研究会
- Place of Presentation
  経団連会館（東京都千代田区）
- Year and Date
  2015-08-01
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] Genetics of Porphyrias2015
- Author(s)
  Eijiro Akasaka, Hajime Nakano
- Organizer
  23th World Congress of Dermatology, Photodermatology Day
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2015-06-08
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] 優性栄養障害型表皮水疱症の遺伝カウンセリング～G2251E変異について～2015
- Author(s)
  赤坂英二郎、鷹木由里子、豊巻由香、澤村大輔、中野　創
- Organizer
  第39回日本遺伝カウンセリング学会学術集会
- Place of Presentation
  三井ガーデンホテル千葉（千葉県千葉市）
- Year and Date
  2015-06-26
- Data Source
  KAKENHI-PROJECT-15K19670
[Presentation] 優性栄養障害型表皮水疱症の遺伝カウンセリング　G2251E変異について2015
- Author(s)
  赤坂英二郎, 鷹木由里子, 豊巻由香, 澤村大輔, 中野創
- Organizer
  第39回日本遺伝カウンセリング学会学術集会
- Place of Presentation
  三井ガーデンホテル千葉（千葉県千葉市）
- Year and Date
  2015-06-26
- Data Source
  KAKENHI-PROJECT-15K09739
[Presentation] SERPINB7変異を同定した長島型掌蹠角化症の1例2014
- Author(s)
  赤坂英二郎，鷹木由里子，豊巻由香，中野　創，澤村大輔，矢口　直
- Organizer
  日本皮膚科学会青森地方会第366回例会
- Place of Presentation
  ホテルニューキャッスル（弘前）
- Year and Date
  2014-05-25
- Data Source
  KAKENHI-PROJECT-25860929
[Presentation] 長島型掌蹠角化症型の遺伝子診断2014
- Author(s)
  櫻庭裕佑、赤坂英二郎、六戸大樹、中野創、澤村大輔
- Organizer
  第29回角化症研究会
- Place of Presentation
  東京商工会議所（東京）
- Year and Date
  2014-08-02
- Data Source
  KAKENHI-PROJECT-26461653
[Presentation] 長島型掌蹠角化症型の遺伝子診断2014
- Author(s)
  櫻庭裕佑、赤坂英二郎、六戸大樹、中野創、澤村大輔
- Organizer
  第29回角化症研究会
- Place of Presentation
  東京商工会議所（東京）
- Year and Date
  2014-08-02
- Data Source
  KAKENHI-PROJECT-25860929
[Presentation] SERPINB7変異を同定した長島型掌蹠角化症の1例2014
- Author(s)
  1.赤坂英二郎，鷹木由里子，豊巻由香，中野　創，澤村大輔，矢口　直
- Organizer
  日本皮膚科学会青森地方会第366回例会
- Place of Presentation
  ホテルニューキャッスル（弘前市）
- Year and Date
  2014-05-25
- Data Source
  KAKENHI-PROJECT-26461653
[Presentation] 多発する稗粒腫を主症状とした優性栄養障害型表皮水疱症2013
- Author(s)
  赤坂英二郎、中野　創、鷹木由里子、豊巻由香、澤村大輔、中野あおい、玉井克人、野村和夫、三橋善比古、橋本　功
- Organizer
  第35回水疱症研究会
- Place of Presentation
  大分県労働福祉会館ソレイユ
- Data Source
  KAKENHI-PROJECT-25860929
[Presentation] 末梢血単核球におけるVII型コラーゲンのmRNA発現について2013
- Author(s)
  赤坂英二郎、中野　創、高橋育子、鷹木由里子、豊巻由香、澤村大輔
- Organizer
  第20回分子皮膚科学フォーラム
- Place of Presentation
  浅草ビューホテル
- Data Source
  KAKENHI-PROJECT-25860929
[Presentation] 骨膜性軟骨腫との鑑別を要した爪下外骨腫の1例2012
- Author(s)
  中島康爾、赤坂英二郎、六戸亜希子、六戸大樹、皆川智子、会津隆幸、中野創、澤村大輔
- Organizer
  日本皮膚科学会青森地方会第359回例会
- Place of Presentation
  青森市
- Year and Date
  2012-09-25
- Data Source
  KAKENHI-PROJECT-24659518
[Presentation] Amelanotic malignant melanoma with rhabdoid features, a rare variant of malignant Melanoma2012
- Author(s)
  KANEKO T, KOREKAWA A, AKASAKA E, NAKANO H, SAWAMURA D
- Organizer
  2nd Eastern Asia Dermatology Congress
- Place of Presentation
  Beijing(China)
- Data Source
  KAKENHI-PROJECT-24659518
[Presentation] 表皮水疱症の遺伝子診断～劣性栄養障害型表皮水疱症について～
- Author(s)
  赤坂英二郎、中野　創、鷹木由里子、豊巻由香、澤村大輔、中野あおい、玉井克人、野村和夫、三橋善比古、橋本　功
- Organizer
  日本皮膚科学会青森地方会第364回例会
- Place of Presentation
  弘前大学医学部コミュニケーションセンター
- Data Source
  KAKENHI-PROJECT-25860929
[Presentation] 栄養障害型表皮水疱症133家系のCOL7A1遺伝子変異解析
- Author(s)
  赤坂英二郎、中野　創、鷹木由里子、豊巻由香、中野あおい、玉井克人、野村和夫、三橋善比古、橋本　功、澤村大輔
- Organizer
  第113回日本皮膚科学会総会
- Place of Presentation
  国立京都国際会館(京都）
- Year and Date
  2014-05-30 – 2014-06-01
- Data Source
  KAKENHI-PROJECT-25860929
[Presentation] 点状掌蹠角化症の2家系例
- Author(s)
  赤坂英二郎、中野　創、澤村大輔
- Organizer
  第28回角化症研究会
- Place of Presentation
  東京商工会議所
- Data Source
  KAKENHI-PROJECT-25860929
[Presentation] 唾液由来DNAを用いてPPOX遺伝子変異を同定した異型ポルフィリン症のカンボジア人1家系例
- Author(s)
  赤坂英二郎，豊巻由香，澤村大輔，中野　創
- Organizer
  第3回光皮膚科学研究会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25860929
[Presentation] 表皮水疱症の遺伝子診断～優性栄養障害型表皮水疱症について～
- Author(s)
  赤坂英二郎、中野　創、鷹木由里子、豊巻由香、澤村大輔、中野あおい、玉井克人、野村和夫、三橋善比古、橋本　功
- Organizer
  日本皮膚科学会青森地方会第363回例会
- Place of Presentation
  八戸パークホテル
- Data Source
  KAKENHI-PROJECT-25860929
[Presentation] Mutational analysis of 133 Japanese pedigrees of dystrophic epidermolysis bullosa
- Author(s)
  Akasaka E, Nakano H, Sawamura D
- Organizer
  3rd Eastern Asia Dermatology Congress
- Place of Presentation
  Jeju, Korea (済州島、韓国)
- Year and Date
  2014-09-24 – 2014-09-26
- Data Source
  KAKENHI-PROJECT-25860929

1. SAWAMURA Daisuke (60196334)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. NAKANO Hajime (90281922)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
3. 六戸大樹 (50436036)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. Nakajima Koji (70374832)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 松崎康司 (50322946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 沢村大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 26 results
7. 金子高英

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Akasaka Eijiro 赤坂 英二郎

AKASAKA Eijiro 赤坂 英二郎

Research Projects

Research Products

Co-Researchers

遺伝性ポルフィリン症におけるヘム生合成に関する新規代謝経路の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

TGF-beta Signaling in fibrosis of recessive dystrophic epidermolysis bullosaPrincipal Investigator

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Richner-Hanhart症候群の高チロシン血症に伴う掌蹠過角化の発症機構Principal Investigator

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COL7A1 expression in the peripheral blood mononuclear cells

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Is there any responsible genetic factor other than mutation of COL7A1 underlying pathogenesis of dystrophic epidermolysis bullosa?Principal Investigator

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The elucidation of mechanism of hyperkeratosis and development of protein replacement therapy in patients with Mal de Meleda.

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Mutational analysis of palmoplantar keratoderma caused by keratin 6c mutationPrincipal Investigator

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Establishment of method using spin labeling that evaluates function and structure of lipids between corneal layers.

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[Journal Article] A case of adult‐onset localized recessive dystrophic epidermolysis bullosa, harboring the novel COL7A1 mutation p.G2754E and the previously reported mutation p.R1763*2023

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[Journal Article] Two cases of the intermediate phenotype of recessive dystrophic epidermolysis bullosa harboring the novel COL7A1 mutation c.3570G&gt;A2022

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[Journal Article] Availability of mRNA Obtained from Peripheral Blood Mononuclear Cells for Testing Mutation Consequences in Dystrophic Epidermolysis Bullosa2021

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[Journal Article] Diversity of Mechanisms Underlying Latent TGF-b Activation in Recessive Dystrophic Epidermolysis Bullosa2020

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[Journal Article] The first case of multiple pilomatricomas caused by somatic mutations of CTNNB1 without any associated disorder.2017

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[Journal Article] Multiple milia as an isolated skin manifestation of dominant dystrophic epidermolysis bullosa: Evidence of phenotypic variability.2017

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Akasaka Eijiro 赤坂英二郎

AKASAKA Eijiro 赤坂英二郎

[Journal Article] Two cases of the intermediate phenotype of recessive dystrophic epidermolysis bullosa harboring the novel COL7A1 mutation c.3570G>A2022

[Journal Article] 【似たもの同士:目で見る鑑別診断2016-水疱性病変編】 (Part4.)下肢(case 14)　優性栄養障害型表皮水疱症(痒疹型)vs結節性痒疹(解説/特集).2016