KOHYAMA JUN 神山淳

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KOHYAMA Jun 神山淳

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Researcher Number	30437511
Other IDs
Affiliation (Current)	2025: 早稲田大学, 人間科学学術院, 教授 2025: 慶應義塾大学, 医学部(信濃町), 准教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 慶應義塾大学, 医学部(信濃町), 准教授 2016 – 2017: 慶應義塾大学, 医学部(信濃町), 准教授 2015 – 2016: 慶應義塾大学, 医学部, 准教授 2014: 慶應義塾大学, 医学部, 特任講師 2007 – 2009: Nara Institute of Science and Technology, バイオサイエンス研究科, 助教 2008: 奈良先端科技大, バイオサイエンス研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Pathological medical chemistry / Orthopaedic surgery / General medical chemistry / Nerve anatomy/Neuropathology
Keywords	Principal Investigator エピジェネティクス / 脊髄損傷 / アストロサイト / 神経幹細胞 / グリア細胞 / 再生医療 / 1細胞ATAC-Seq / 1細胞RNA-Seq / iPS細胞由来脳オルガノイド溝田 / ＣHARＧE症候群 … More / エンハンサー制御 / iPS細胞由来脳オルガノイド / iPS細胞 / 脳オルガノイド / CHARGE症候群 / シグナル伝達 / 共培養 / 試験管内モデル / ニューロン / バイオインフォマティクス / 神経変性疾患 / 細胞間相互作用 / オリゴデンドロサイト前駆細胞 / 神経科学 / Notchシグナル / アストロサイ / ES細胞 / DNAメチル化 / 胚性幹細胞 / NRSF / REST / 骨形成因子 Less

慢性期損傷脊髄における細胞移植治療による薬効メカニズムの解明Principal Investigator
- Principal Investigator
  
  神山淳
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Keio University
Unraveling mechanism of pathogenesis in CHAREGE syndrome using iPSC-derived brain organoidPrincipal Investigator
- Principal Investigator
  
  KOHYAMA JUN
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Keio University
Development of new technology to analyze cellular interaction between neuron and glial cellsPrincipal Investigator
- Principal Investigator
  
  KOHYAMA JUN
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
Crosstalk between immune system and nervous system in the pathogenesis of spinal cord injuryPrincipal Investigator
- Principal Investigator
  
  KOHYAMA JUN
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Site-specific epigenetic regulation in cell fate decision of neural progenitor cellsPrincipal Investigator
- Principal Investigator
  
  KOHYAMA Jun
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Nara Institute of Science and Technology
神経系細胞の分化形質及び可塑性を規定する分子群の解析Principal Investigator
- Principal Investigator
  
  神山淳
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Nara Institute of Science and Technology

All 2024 2023 2022 2020 2018 2017 2016 2015 2010 2009 Other

All Journal Article Presentation

[Journal Article] Human-induced pluripotent stem cell-derived neural stem/progenitor cell ex vivo gene therapy with synaptic organizer CPTX for spinal cord injury2024
- Author(s)
  Saijo Y, Nagoshi N, Kawai M, Kitagawa T, Suematsu Y, Ozaki M, Shinozaki M, Kohyama J, Shibata S, Takeuchi K, Nakamura M, Yuzaki M, Okano H.
- Journal Title
  
  Stem Cell Reports.
  
  Volume: 19 Issue: 3 Pages: 100393-100393
- DOI
  10.1016/j.stemcr.2024.01.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19590, KAKENHI-PUBLICLY-22H04786, KAKENHI-PROJECT-19H03623, KAKENHI-PROJECT-23K24464
[Journal Article] Current status and prospects of regenerative medicine for spinal cord injury using human induced pluripotent stem cells: a review2023
- Author(s)
  Inoue Mitsuhiro、Yamaguchi Ryo、He Ching Chi Jimmy、Ikeda Atsushi、Okano Hideyuki、Kohyama Jun
- Journal Title
  
  Stem Cell Investigation
  
  Volume: 10 Pages: 6-6
- DOI
  10.21037/sci-2022-037
- Data Source
  KAKENHI-PROJECT-19H03623
[Journal Article] Mesenchymal properties of iPSC-derived neural progenitors that generate undesired grafts after transplantation2023
- Author(s)
  Isoda Miho、Sanosaka Tsukasa、Tomooka Ryo、Mabuchi Yo、Shinozaki Munehisa、Andoh-Noda Tomoko、Banno Satoe、Mizota Noriko、Yamaguchi Ryo、Okano Hideyuki、Kohyama Jun
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 611-611
- DOI
  10.1038/s42003-023-04995-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03623
[Journal Article] Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis2023
- Author(s)
  Iga Takahito、Kobayashi Hiroshi、Kusumoto Dai、Sanosaka Tsukasa、Fujita Nobuyuki、Tai-Nagara Ikue、Ando Tomofumi、Takahashi Tomoko et.al
- Journal Title
  
  Nature Cell Biology
  
  Volume: 25 Issue: 10 Pages: 1415-1425
- DOI
  10.1038/s41556-023-01240-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23KJ1885, KAKENHI-PROJECT-22K06915, KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-19H03623, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-21H03057, KAKENHI-PROJECT-23K21467, KAKENHI-PROJECT-23K27352
[Journal Article] Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms2022
- Author(s)
  Ideno Hirosato、Imaizumi Kent、Shimada Hiroko、Sanosaka Tsukasa、Nemoto Akisa、Kohyama Jun、Okano Hideyuki
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 10 Pages: 105140-105140
- DOI
  10.1016/j.isci.2022.105140
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03623, KAKENHI-PUBLICLY-21H00438
[Journal Article] Administration of C5a Receptor Antagonist Improves the Efficacy of Human Induced Pluripotent Stem Cell Derived Neural Stem/Progenitor Cell Transplantation in the Acute Phase of Spinal Cord Injury2022
- Author(s)
  Shibata Reo、Nagoshi Narihito、Kajikawa Keita、Ito Shuhei、Shibata Shinsuke、Shindo Tomoko、Khazaei Mohamad、Nori Satoshi、Kohyama Jun、Fehlings Michael G.、Matsumoto Morio、Nakamura Masaya、Okano Hideyuki
- Journal Title
  
  Journal of Neurotrauma
  
  Volume: 39 Issue: 9-10 Pages: 667-682
- DOI
  10.1089/neu.2021.0225
- Data Source
  KAKENHI-PROJECT-19H03623
[Journal Article] Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury2022
- Author(s)
  Kitagawa Takahiro、Nagoshi Narihito、Kamata Yasuhiro、Kawai Momotaro、Ago Kentaro、Kajikawa Keita、Shibata Reo、Sato Yuta、Imaizumi Kent、Shindo Tomoko、Shinozaki Munehisa、Kohyama Jun、Shibata Shinsuke、Matsumoto Morio、Nakamura Masaya、Okano Hideyuki
- Journal Title
  
  Stem Cell Reports
  
  Volume: 17 Issue: 1 Pages: 127-142
- DOI
  10.1016/j.stemcr.2021.12.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03623, KAKENHI-PROJECT-19H03983, KAKENHI-PROJECT-23K24464
[Journal Article] Chromatin remodeler CHD7 targets active enhancer region to regulate cell type-specific gene expression in human neural crest cells.2022
- Author(s)
  Tsukasa Sanosaka, Hironobu Okuno, Noriko Mizota, Tomoko Andoh-Noda, Miki Sato, Ryo Tomooka, Satoe Banno, Jun Kohyama, Hideyuki Okano.
- Journal Title
  
  Scientific reports
  
  Volume: 12 Issue: 1 Pages: 22648-22648
- DOI
  10.1038/s41598-022-27293-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06396, KAKENHI-PROJECT-19H03623, KAKENHI-PROJECT-22KJ2656
[Journal Article] A non-invasive system to monitor in vivo neural graft activity after spinal cord injury2022
- Author(s)
  Ago K、Nagoshi N、Imaizumi K、Kitagawa T、Kawai M、Kajikawa K、Shibata R、Kamata Y、Kojima K、Shinozaki M、Kondo T、Iwano S、Miyawaki A、Ohtsuka M、Bito H、Kobayashi K、Shibata S、Shindo T、Kohyama J、Matsumoto M、Nakamura M、Okano H
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 803-803
- DOI
  10.1038/s42003-022-03736-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03623, KAKENHI-PROJECT-20H03178, KAKENHI-PUBLICLY-21H00438, KAKENHI-PLANNED-17H06312, KAKENHI-PROJECT-23K24464
[Journal Article] Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice2022
- Author(s)
  Matsubara T, Iga T, Sugiura Y, Kusumoto D, Sanosaka T, Tai-Nagara I, Takeda N, Fong GH, Ito K, Ema M, Okano H, Kohyama J, Suematsu M, *Kubota Y.
- Journal Title
  
  J Exp Med
  
  Volume: 219 Issue: 4
- DOI
  10.1084/jem.20211789
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07389, KAKENHI-PROJECT-19K08549, KAKENHI-PROJECT-19H03397, KAKENHI-PROJECT-22K06915, KAKENHI-PROJECT-19H03623
[Journal Article] A robust culture system to generate neural progenitors with gliogenic competence from clinically relevant induced pluripotent stem cells for treatment of spinal cord injury2020
- Author(s)
  Kamata Yasuhiro、Isoda Miho、Sanosaka Tsukasa、Shibata Reo、Ito Shuhei、Okubo Toshiki、Shinozaki Munehisa、Inoue Mitsuhiro、Koya Ikuko、Shibata Shinsuke、Shindo Tomoko、Matsumoto Morio、Nakamura Masaya、Okano Hideyuki、Nagoshi Narihito、Kohyama Jun
- Journal Title
  
  STEM CELLS Translational Medicine
  
  Volume: 10 Issue: 3 Pages: 398-413
- DOI
  10.1002/sctm.20-0269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03623, KAKENHI-PROJECT-18K14840
[Journal Article] Chromatin remodeler CHD7 regulates the stem cell identity of human neural progenitors2018
- Author(s)
  Chai MuhChyi、Sanosaka Tsukasa、Okuno Hironobu、Zhou Zhi、Koya Ikuko、Banno Satoe、Andoh-Noda Tomoko、Tabata Yoshikuni、Shimamura Rieko、Hayashi Tetsutaro、Ebisawa Masashi、Sasagawa Yohei、Nikaido Itoshi、Okano Hideyuki、Kohyama Jun
- Journal Title
  
  Genes & Development
  
  Volume: 32 Issue: 2 Pages: 165-180
- DOI
  10.1101/gad.301887.117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26713047, KAKENHI-PROJECT-16K15240
[Journal Article] Whole-Genome DNA Methylation Analyses Revealed Epigenetic Instability in Tumorigenic Human iPS Cell-Derived Neural Stem/Progenitor Cells.2017
- Author(s)
  Iida T, Iwanami A, Sanosaka T, Kohyama J, Miyoshi H, Nagoshi N, Kashiwagi R, Toyama Y, Matsumoto M, Nakamura M, Okano H.
- Journal Title
  
  Stem Cells
  
  Volume: 35 Issue: 5 Pages: 1316-1327
- DOI
  10.1002/stem.2581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10422, KAKENHI-PROJECT-26713047
[Journal Article] Low immunogenicity of mouse induced pluripotent stem cell-derived neural stem/progenitor cells2017
- Author(s)
  Itakura Go、Ozaki Masahiro、Nagoshi Narihito、Kawabata Soya、Nishiyama Yuichiro、Sugai Keiko、Iida Tsuyoshi、Kashiwagi Rei、Ookubo Toshiki、Yastake Kaori、Matsubayashi Kohei、Kohyama Jun、Iwanami Akio、Matsumoto Morio、Nakamura Masaya、Okano Hideyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41598-017-13522-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26713047
[Journal Article] Grafted human iPS cell-derived oligodendrocyte precursor cells contribute to robust remyelination of demyelinated axons after spinal cord injury2016
- Author(s)
  Kawabata S, Takano M, Numasawa-Kuroiwa Y, Itakura G, Kobayashi Y, Nishiyama Y, Sugai K, Nishimura S, Iwai H, Isoda M, Shibata S, Kohyama J, Iwanami A, Toyama Y, Matsumoto M, Nakamura M, Okano H,
- Journal Title
  
  Stem Cell Reports
  
  Volume: 6(1) Issue: 1 Pages: 1-8
- DOI
  10.1016/j.stemcr.2015.11.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462714, KAKENHI-PROJECT-26713047
[Journal Article] TLR9 signaling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus2015
- Author(s)
  Matsuda T., Murao N., Katano Y., Juliandi B., Kohyama J., Akira S., Kawai T. & Nakashima K
- Journal Title
  
  Nat Commun
  
  Volume: 6 Issue: 1 Pages: 6514-6514
- DOI
  10.1038/ncomms7514
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J09007, KAKENHI-PUBLICLY-25110721, KAKENHI-PUBLICLY-25123714, KAKENHI-PROJECT-26670236, KAKENHI-PROJECT-26713047, KAKENHI-PUBLICLY-15H01381, KAKENHI-PROJECT-15H06474, KAKENHI-PROJECT-26293107
[Journal Article] BMP-induced REST regulates the establishment and maintenance of astrocytic identity.2010
- Author(s)
  Kohyama J, Sanosaka T, Tokunaga A, Takatsuka E, Tsujimura K, Okano H, Nakashima K.
- Journal Title
  
  J Cell Biol. 189(1)
  
  Pages: 159-170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790230
[Journal Article] Astrocyte differentiation of neural precursor cells is enhanced by retinoic acid through a change in epigenetic modification.2009
- Author(s)
  Asano H, Aonuma M, Sanosaka T, Kohyama J, Namihira M, Nakashima K.
- Journal Title
  
  Stem Cells. 27(11)
  
  Pages: 2744-2752
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790230
[Journal Article] MeCP2は成体脳における分化可塑性を制御する2009
- Author(s)
  神山淳, 中島欽一
- Journal Title
  
  実験医学 27(6)
- Data Source
  KAKENHI-PROJECT-20790230
[Journal Article] Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP22009
- Author(s)
  Tsujimura K, Abematsu M, Kohyama J, Namihira M, Nakashima K.
- Journal Title
  
  Exp Neurol. 219(1)
  
  Pages: 104-111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790230
[Journal Article] Epigenetic mechanisms regulating neural cell fate determination.2009
- Author(s)
  Nakashima K, Kohyama J, Namihira M, Gage FH, Okano H, Sawamoto K.
- Journal Title
  
  No To Hattatsu. 41(6)
  
  Pages: 411-414
- NAID
  10026133121
- Data Source
  KAKENHI-PROJECT-20790230
[Presentation] マウス脊髄損傷モデルにおけるエピジェネティック修飾関連因子の解析
- Author(s)
  43.堀桂子, 神山淳, 坂野聡重, 岩波明生, 岡野栄之, 戸山芳昭, 中村雅也
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  城山観光ホテル（鹿児島県鹿児島市）
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-26713047

1. IWANAMI Akio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. OKANO Hideyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. NAKAMURA Masaya

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# of Collaborated Products: 1 results
4. IIDA Tsuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 武内恒成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 佐野坂司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 田井育江

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# of Collaborated Products: 1 results
8. 芝田晋介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOHYAMA JUN 神山 淳

KOHYAMA Jun 神山 淳

Research Projects

Research Products

Co-Researchers

慢性期損傷脊髄における細胞移植治療による薬効メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Unraveling mechanism of pathogenesis in CHAREGE syndrome using iPSC-derived brain organoidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new technology to analyze cellular interaction between neuron and glial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Crosstalk between immune system and nervous system in the pathogenesis of spinal cord injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Site-specific epigenetic regulation in cell fate decision of neural progenitor cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経系細胞の分化形質及び可塑性を規定する分子群の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Human-induced pluripotent stem cell-derived neural stem/progenitor cell ex vivo gene therapy with synaptic organizer CPTX for spinal cord injury2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Current status and prospects of regenerative medicine for spinal cord injury using human induced pluripotent stem cells: a review2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mesenchymal properties of iPSC-derived neural progenitors that generate undesired grafts after transplantation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Administration of C5a Receptor Antagonist Improves the Efficacy of Human Induced Pluripotent Stem Cell Derived Neural Stem/Progenitor Cell Transplantation in the Acute Phase of Spinal Cord Injury2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chromatin remodeler CHD7 targets active enhancer region to regulate cell type-specific gene expression in human neural crest cells.2022

Author(s)

Journal Title

DOI

KOHYAMA JUN 神山淳

KOHYAMA Jun 神山淳