KOHYAMA JUN 神山淳

… Alternative Names

神山淳コウヤマジュン

KOHYAMA Jun 神山淳

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Researcher Number	30437511
Other IDs
Affiliation (Current)	2023: 慶應義塾大学, 医学部(信濃町), 准教授
Affiliation (based on the past Project Information) *help	2019 – 2022: 慶應義塾大学, 医学部(信濃町), 准教授 2016 – 2017: 慶應義塾大学, 医学部(信濃町), 准教授 2015 – 2016: 慶應義塾大学, 医学部, 准教授 2014: 慶應義塾大学, 医学部, 特任講師 2007 – 2009: Nara Institute of Science and Technology, バイオサイエンス研究科, 助教 2008: 奈良先端科技大, バイオサイエンス研究科, 助教
Review Section/Research Field	Principal Investigator Nerve anatomy/Neuropathology / General medical chemistry / Orthopaedic surgery / Pathological medical chemistry / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator 神経幹細胞 / アストロサイト / エピジェネティクス / 骨形成因子 / REST / NRSF / 胚性幹細胞 / DNAメチル化 / ES細胞 / アストロサイ … More / 脊髄損傷 / Notchシグナル / 神経科学 / オリゴデンドロサイト前駆細胞 / 細胞間相互作用 / 神経変性疾患 / バイオインフォマティクス / ニューロン / 試験管内モデル / 共培養 / シグナル伝達 / iPS細胞 / 脳オルガノイド / iPS細胞由来脳オルガノイド / CHARGE症候群 / ＣHARＧE症候群 / iPS細胞由来脳オルガノイド溝田 / 1細胞RNA-Seq / 1細胞ATAC-Seq Less

Unraveling mechanism of pathogenesis in CHAREGE syndrome using iPSC-derived brain organoidPrincipal Investigator
- Principal Investigator
  
  神山淳
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Keio University
Development of new technology to analyze cellular interaction between neuron and glial cellsPrincipal Investigator
- Principal Investigator
  
  KOHYAMA JUN
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
Crosstalk between immune system and nervous system in the pathogenesis of spinal cord injuryPrincipal Investigator
- Principal Investigator
  
  KOHYAMA JUN
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Site-specific epigenetic regulation in cell fate decision of neural progenitor cellsPrincipal Investigator
- Principal Investigator
  
  KOHYAMA Jun
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Nara Institute of Science and Technology
神経系細胞の分化形質及び可塑性を規定する分子群の解析Principal Investigator
- Principal Investigator
  
  神山淳
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Nara Institute of Science and Technology

All 2022 2020 2018 2017 2016 2015 2010 2009 Other

All Journal Article Presentation

[Journal Article] Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury2022
- Author(s)
  Kitagawa Takahiro、Nagoshi Narihito、Kamata Yasuhiro、Kawai Momotaro、Ago Kentaro、Kajikawa Keita、Shibata Reo、Sato Yuta、Imaizumi Kent、Shindo Tomoko、Shinozaki Munehisa、Kohyama Jun、Shibata Shinsuke、Matsumoto Morio、Nakamura Masaya、Okano Hideyuki
- Journal Title
  
  Stem Cell Reports
  
  Volume: 17 Pages: 127-142
- DOI
  10.1016/j.stemcr.2021.12.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03623, KAKENHI-PROJECT-19H03983
[Journal Article] Administration of C5a Receptor Antagonist Improves the Efficacy of Human Induced Pluripotent Stem Cell Derived Neural Stem/Progenitor Cell Transplantation in the Acute Phase of Spinal Cord Injury2022
- Author(s)
  Shibata Reo、Nagoshi Narihito、Kajikawa Keita、Ito Shuhei、Shibata Shinsuke、Shindo Tomoko、Khazaei Mohamad、Nori Satoshi、Kohyama Jun、Fehlings Michael G.、Matsumoto Morio、Nakamura Masaya、Okano Hideyuki
- Journal Title
  
  Journal of Neurotrauma
  
  Volume: 39 Pages: 667-682
- DOI
  10.1089/neu.2021.0225
- Data Source
  KAKENHI-PROJECT-19H03623
[Journal Article] A robust culture system to generate neural progenitors with gliogenic competence from clinically relevant induced pluripotent stem cells for treatment of spinal cord injury2020
- Author(s)
  Kamata Yasuhiro、Isoda Miho、Sanosaka Tsukasa、Shibata Reo、Ito Shuhei、Okubo Toshiki、Shinozaki Munehisa、Inoue Mitsuhiro、Koya Ikuko、Shibata Shinsuke、Shindo Tomoko、Matsumoto Morio、Nakamura Masaya、Okano Hideyuki、Nagoshi Narihito、Kohyama Jun
- Journal Title
  
  STEM CELLS Translational Medicine
  
  Volume: 10 Pages: 398-413
- DOI
  10.1002/sctm.20-0269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03623, KAKENHI-PROJECT-18K14840
[Journal Article] Chromatin remodeler CHD7 regulates the stem cell identity of human neural progenitors2018
- Author(s)
  Chai MuhChyi、Sanosaka Tsukasa、Okuno Hironobu、Zhou Zhi、Koya Ikuko、Banno Satoe、Andoh-Noda Tomoko、Tabata Yoshikuni、Shimamura Rieko、Hayashi Tetsutaro、Ebisawa Masashi、Sasagawa Yohei、Nikaido Itoshi、Okano Hideyuki、Kohyama Jun
- Journal Title
  
  Genes & Development
  
  Volume: 32 Pages: 165-180
- DOI
  10.1101/gad.301887.117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26713047, KAKENHI-PROJECT-16K15240
[Journal Article] Low immunogenicity of mouse induced pluripotent stem cell-derived neural stem/progenitor cells2017
- Author(s)
  Itakura Go、Ozaki Masahiro、Nagoshi Narihito、Kawabata Soya、Nishiyama Yuichiro、Sugai Keiko、Iida Tsuyoshi、Kashiwagi Rei、Ookubo Toshiki、Yastake Kaori、Matsubayashi Kohei、Kohyama Jun、Iwanami Akio、Matsumoto Morio、Nakamura Masaya、Okano Hideyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 1-13
- DOI
  10.1038/s41598-017-13522-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26713047
[Journal Article] Whole-Genome DNA Methylation Analyses Revealed Epigenetic Instability in Tumorigenic Human iPS Cell-Derived Neural Stem/Progenitor Cells2017
- Author(s)
  Iida T, Iwanami A, Sanosaka T, Kohyama J, Miyoshi H, Nagoshi N, Kashiwagi R, Toyama Y, Matsumoto M, Nakamura M, Okano H.
- Journal Title
  
  STEM CELLS
  
  Volume: 35 Pages: 1316-1327
- DOI
  10.1002/stem.2581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10422, KAKENHI-PROJECT-26713047
[Journal Article] Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury.2016
- Author(s)
  Kawabata S, Takano M, Numasawa-Kuroiwa Y, Itakura G, Kobayashi Y, Nishiyama Y, Sugai K, Nishimura S, Iwai H, Isoda M, Shibata S, Kohyama J, Iwanami A, Toyama Y, Matsumoto M, Nakamura M, Okano H,
- Journal Title
  
  Stem Cell Reports
  
  Volume: 6(1) Pages: 1-8
- DOI
  10.1016/j.stemcr.2015.11.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462714, KAKENHI-PROJECT-26713047
[Journal Article] TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.2015
- Author(s)
  Matsuda T., Murao N., Katano Y., Juliandi B., Kohyama J., Akira S., Kawai T. & Nakashima K
- Journal Title
  
  Nature communications
  
  Volume: 6 Pages: 1-10
- DOI
  10.1038/ncomms7514
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J09007, KAKENHI-PUBLICLY-25110721, KAKENHI-PUBLICLY-25123714, KAKENHI-PROJECT-26670236, KAKENHI-PROJECT-26713047, KAKENHI-PUBLICLY-15H01381, KAKENHI-PROJECT-15H06474, KAKENHI-PROJECT-26293107
[Journal Article] BMP-induced REST regulates the establishment and maintenance of astrocytic identity.2010
- Author(s)
  Kohyama J, Sanosaka T, Tokunaga A, Takatsuka E, Tsujimura K, Okano H, Nakashima K.
- Journal Title
  
  J Cell Biol. 189(1)
  
  Pages: 159-170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790230
[Journal Article] Astrocyte differentiation of neural precursor cells is enhanced by retinoic acid through a change in epigenetic modification.2009
- Author(s)
  Asano H, Aonuma M, Sanosaka T, Kohyama J, Namihira M, Nakashima K.
- Journal Title
  
  Stem Cells. 27(11)
  
  Pages: 2744-2752
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790230
[Journal Article] MeCP2は成体脳における分化可塑性を制御する2009
- Author(s)
  神山淳, 中島欽一
- Journal Title
  
  実験医学 27(6)
- Data Source
  KAKENHI-PROJECT-20790230
[Journal Article] Neuronal differentiation of neural precursor cells is promoted by the methyl-CpG-binding protein MeCP22009
- Author(s)
  Tsujimura K, Abematsu M, Kohyama J, Namihira M, Nakashima K.
- Journal Title
  
  Exp Neurol. 219(1)
  
  Pages: 104-111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790230
[Journal Article] Epigenetic mechanisms regulating neural cell fate determination.2009
- Author(s)
  Nakashima K, Kohyama J, Namihira M, Gage FH, Okano H, Sawamoto K.
- Journal Title
  
  No To Hattatsu. 41(6)
  
  Pages: 411-414
- NAID
  10026133121
- Data Source
  KAKENHI-PROJECT-20790230
[Presentation] マウス脊髄損傷モデルにおけるエピジェネティック修飾関連因子の解析
- Author(s)
  43.堀桂子, 神山淳, 坂野聡重, 岩波明生, 岡野栄之, 戸山芳昭, 中村雅也
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  城山観光ホテル（鹿児島県鹿児島市）
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-26713047

1. IWANAMI Akio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. OKANO Hideyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. NAKAMURA Masaya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. IIDA Tsuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. KAWAI Taro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 芝田晋介

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 中島欽一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 松田泰斗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOHYAMA JUN 神山 淳

神山 淳 コウヤマ ジュン

KOHYAMA Jun 神山 淳

Research Projects

Research Products

Co-Researchers

Unraveling mechanism of pathogenesis in CHAREGE syndrome using iPSC-derived brain organoidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new technology to analyze cellular interaction between neuron and glial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Crosstalk between immune system and nervous system in the pathogenesis of spinal cord injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Site-specific epigenetic regulation in cell fate decision of neural progenitor cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経系細胞の分化形質及び可塑性を規定する分子群の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Administration of C5a Receptor Antagonist Improves the Efficacy of Human Induced Pluripotent Stem Cell Derived Neural Stem/Progenitor Cell Transplantation in the Acute Phase of Spinal Cord Injury2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A robust culture system to generate neural progenitors with gliogenic competence from clinically relevant induced pluripotent stem cells for treatment of spinal cord injury2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chromatin remodeler CHD7 regulates the stem cell identity of human neural progenitors2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Low immunogenicity of mouse induced pluripotent stem cell-derived neural stem/progenitor cells2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Whole-Genome DNA Methylation Analyses Revealed Epigenetic Instability in Tumorigenic Human iPS Cell-Derived Neural Stem/Progenitor Cells2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BMP-induced REST regulates the establishment and maintenance of astrocytic identity.2010

Author(s)

Journal Title

Data Source

KOHYAMA JUN 神山淳

神山淳コウヤマジュン

KOHYAMA Jun 神山淳