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HIGUCHI YUKA  樋口 由佳 (江浦 由佳)

ORCIDConnect your ORCID iD *help
… Alternative Names

樋口 由佳  ヒグチ ユカ

江浦 由佳

江浦由佳

EURA Yuka  江浦 由佳

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Researcher Number 30443477
Other IDs
Affiliation (Current) 2023: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員
Affiliation (based on the past Project Information) *help 2023: 国立研究開発法人国立循環器病研究センター, その他部局等, 研究員
2022: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員
2017: 国立研究開発法人国立循環器病研究センター, 研究所, 研究員
2016: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員
2015: 国立研究開発法人国立循環器病研究センター, 研究所, 非常勤研究員
2007 – 2008: 国立循環器病センター研究所, 病因部, 流動研究員
Review Section/Research Field
Principal Investigator
Functional biochemistry / Basic Section 53020:Cardiology-related
Except Principal Investigator
Functional biochemistry / Basic Section 54010:Hematology and medical oncology-related
Keywords
Principal Investigator
ERAD / ER stress / Derlin-3 / Herp / 小胞体関連分解 / 小胞体ストレス / Derlin
Except Principal Investigator
小胞体 / 細胞情報伝達機構 / ストレス応答 … More / 酵素 / シグナル伝達 / ストレス / 蛋白質 / タンパク質品質管理 / プロリン異性化酵素 / ADAMTS13 / Siglec Less
  • Research Projects

    (5 results)
  • Research Products

    (30 results)
  • Co-Researchers

    (11 People)
  •  心内膜特異的に発現するvon Willebrand因子の生理的意義と発現調節機構の解明Principal Investigator

    • Principal Investigator
      樋口 由佳 (江浦 由佳)
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  血小板リガンドとSiglecの相互作用による好中球・単球の血栓形成促進機構の解明

    • Principal Investigator
      秋山 正志
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Analysis of molecular mechanism of cell protective function of Derlin-3Principal Investigator

    • Principal Investigator
      Eura Yuka
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Quality control of secretory proteins containing proline residues in the cis form

    • Principal Investigator
      KOKAME KOICHI
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Research on protein quality control by the endoplasmic reticulum membrane proteins

    • Principal Investigator
      KOKAME Koichi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional biochemistry
    • Research Institution
      National Cardiovascular Center Research Institute

All 2018 2017 2016 2015 2014 2013 2008 2007 Other

All Journal Article Presentation Book

  • [Book] 生化学2017

    • Author(s)
      宮田敏行,樋口(江浦)由佳,杉本充彦
    • Total Pages
      10
    • Publisher
      公益社団法人 日本生化学会
    • Data Source
      KAKENHI-PROJECT-15K18510
  • [Journal Article] Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca 2+ -calcineurin-Akt axis2018

    • Author(s)
      Navarro-Marquez Mario、Torrealba Natalia、Troncoso Rodrigo、V?squez-Trincado Cesar、Rodriguez Marcelo、Morales Pablo E.、Villalobos Elisa、Eura Yuka、Garcia Lorena、Chiong Mario、Klip Amira、Jaimovich Enrique、Kokame Koichi、Lavandero Sergio
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

      Volume: 1864 Pages: 1653-1662

    • DOI

      10.1016/j.bbadis.2018.02.018

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07358, KAKENHI-PROJECT-15K18510
  • [Journal Article] Candidate gene analysis using genomic quantitative PCR: Identification of <i>ADAMTS13</i> large deletions in two patients with Upshaw-Schulman syndrome2017

    • Author(s)
      Yuka Eura
    • Journal Title

      Japanese Journal of Thrombosis and Hemostasis

      Volume: 28 Issue: 4 Pages: 537-542

    • DOI

      10.2491/jjsth.28.537

    • NAID

      130005966818

    • ISSN
      0915-7441, 1880-8808
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K18510
  • [Journal Article] Revised mechanisms of thrombus formation and next-generation anti-thrombotic strategy2017

    • Author(s)
      Toshiyuki Miyata, Yuka Eura, Mitsuhiko Sugimoto
    • Journal Title

      生化学

      Volume: 89 Issue: 3 Pages: 333-342

    • DOI

      10.14952/SEIKAGAKU.2017.890333

    • NAID

      40021265126

    • ISSN
      0037-1017
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K18510
  • [Journal Article] Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation2017

    • Author(s)
      Torrealba Natalia、Navarro-Marquez Mario、Garrido Valeria、Pedrozo Zully、Romero Diego、Eura Yuka、Villalobos Elisa、Roa Juan Carlos、Chiong Mario、Kokame Koichi、Lavandero Sergio
    • Journal Title

      Scientific Reports

      Volume: 7 Pages: 13402-13402

    • DOI

      10.1038/s41598-017-13797-z

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07358, KAKENHI-PROJECT-15K18510
  • [Journal Article] 先天性TTP(血栓性血小板減少性紫斑病)の遺伝子解析.2016

    • Author(s)
      小亀浩市, 樋口(江浦)由佳.
    • Journal Title

      血栓と循環

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K18510
  • [Journal Article] Influence of a rotational speed modulation system used with an implantable continuous-flow left ventricular assist device on von Willebrand factor dynamics2016

    • Author(s)
      Noritsugu Naito, Toshihide Mizuno, Takashi Nishimura, Satoru Kishimoto, Yoshiaki Takewa, Yuka Eura, Koichi Kokame, Toshiyuki Miyata, Kazuma Date, Akihide Umeki, Masahiko Ando, Minoru Ono, and Eisuke Tatsumi
    • Journal Title

      Artificial Organs

      Volume: 未定 Pages: 877-883

    • DOI

      10.1111/aor.12666

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25440060, KAKENHI-PROJECT-25560217, KAKENHI-PROJECT-25293294, KAKENHI-PROJECT-15K18510, KAKENHI-PROJECT-16K09834
  • [Journal Article] Genetic variations in complement factors in patients with congenital thrombotic thrombocytopenic purpura with renal insufficiency2016

    • Author(s)
      Fan X, Kremer Hovinga JA, Shirotani-Ikejima H, Eura Y, Hirai H, Honda S, Kokame K, Taleghani MM, von Krogh AS, Yoshida Y, Fujimura Y, Lammle B, Miyata T
    • Journal Title

      Int J Hematol.

      Volume: 103 Pages: 283-291

    • DOI

      10.1007/s12185-015-1933-7

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09463, KAKENHI-PROJECT-25440060, KAKENHI-PROJECT-15K18510
  • [Journal Article] 先天性TTP(血栓性血小板減少性紫斑病)の遺伝子解析2016

    • Author(s)
      樋口(江浦)由佳, 小亀浩市
    • Journal Title

      血栓と循環

      Volume: 24

    • Data Source
      KAKENHI-PROJECT-25440060
  • [Journal Article] Candidate gene analysis using genomic quantitative PCR: identification of ADAMTS13 large deletions in two patients with Upshaw-Schulman syndrome2014

    • Author(s)
      Eura Y, Kokame K, Takafuta T, Tanaka R, Kobayashi H, Ishida F, Hisanaga S, Matsumoto M, Fujimura Y, Miyata T.
    • Journal Title

      Molecular Genetics & Genomic Medicine

      Volume: 2 Pages: 240-244

    • DOI

      10.1002/mgg3.64

    • NAID

      130005966818

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23591425, KAKENHI-PROJECT-24390250, KAKENHI-PROJECT-25440060, KAKENHI-PROJECT-25461456
  • [Journal Article] ターゲット領域の異常を見逃さないゲノム定量PCR法の確立2014

    • Author(s)
      樋口(江浦)由佳,小亀浩市,宮田敏行
    • Journal Title

      日本血栓止血学会誌

      Volume: 25 Pages: 615-618

    • Data Source
      KAKENHI-PROJECT-25440060
  • [Journal Article] Upshaw-Schulman症候群のADAMTS13遺伝子解析2014

    • Author(s)
      小亀浩市,樋口(江浦)由佳
    • Journal Title

      細胞

      Volume: 46 Pages: 61-63

    • Data Source
      KAKENHI-PROJECT-25440060
  • [Journal Article] 小胞体逆輸送の謎にせまるin vitro アッセイ法2007

    • Author(s)
      江浦由佳
    • Journal Title

      蛋白質核酸酵素 52

      Pages: 1474-1475

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19570147
  • [Journal Article] 小胞体関連分解におけるAAA-ATPase, p97 の役割2007

    • Author(s)
      江浦由佳
    • Journal Title

      蛋白質核酸酵素 52

      Pages: 74-75

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19570147
  • [Presentation] Genetic, biochemical, and physiological approach to understanding the function of Herp and Derlin family proteins in ER-associated degradation machinery2017

    • Author(s)
      Koichi Kokame and Yuka Eura
    • Organizer
      ACCDiS Symposium 7 at XL Annual Meeting of the Chilean Society of Biochemistry and Molecular Biology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18510
  • [Presentation] 小胞体膜タンパク質Derlin-3は小胞体ストレスによる小胞体関連分解(ERAD)複合体の変化に必要である2016

    • Author(s)
      樋口(江浦)由佳,池島裕子,宮田敏行,小亀浩市
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-15K18510
  • [Presentation] 植え込み型補助人工心臓が血中von Willebrand factorに与える影響に関する研究2015

    • Author(s)
      水野敏秀, 内藤敬嗣, 樋口(江浦)由佳, 小亀浩市, 宮田敏行, 築谷朋典, 武輪能明, 巽英介
    • Organizer
      第53回人工臓器学会大会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-19
    • Data Source
      KAKENHI-PROJECT-25440060
  • [Presentation] 補助人工心臓による高分子量VWFマルチマーの減少は循環開始直後に始まる.2015

    • Author(s)
      樋口(江浦)由佳,小亀浩市,水野敏秀,巽英介,宮田敏行.
    • Organizer
      第37回日本血栓止血学会学術集会
    • Place of Presentation
      甲府市
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-15K18510
  • [Presentation] 定常流型左室補助人工心臓に用いる自己心拍同期回転数制御システムがvon Willebrand factorに及ぼす影響2015

    • Author(s)
      内藤敬嗣, 西村隆, 岸本諭, 水野敏秀, 武輪能明, 樋口(江浦)由佳, 小亀浩市, 宮田敏行, 小野稔, 巽英介
    • Organizer
      第53回人工臓器学会大会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-19
    • Data Source
      KAKENHI-PROJECT-25440060
  • [Presentation] 補助人工心臓装着による高分子量VWFマルチマーの減少は循環開始直後に始まる2015

    • Author(s)
      樋口(江浦)由佳, 小亀浩市, 水野敏秀, 巽英介, 宮田敏行
    • Organizer
      第37回日本血栓止血学会学術集会
    • Place of Presentation
      甲府
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-25440060
  • [Presentation] Influence of a rotational speed modulation of an implantable continuous-flowleft ventricular assist device (EVAHEART) on von Willebrand factor dynamics2015

    • Author(s)
      Noritsugu Naito, Toshihide Mizuno, Takashi Nishimura, Satoru Kishimoto, Yoshiaki Takewa, Yuka Eura, Koichi Kokame, Toshiyuki Miyata, Minoru Ono, and Eisuke Tatsumi
    • Organizer
      The 23rd Annual Meeting of the International Society for Rotary Blood Pumps (ISRBP)
    • Place of Presentation
      Dubrovnik
    • Year and Date
      2015-09-27
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25440060
  • [Presentation] 血栓性血小板減少性紫斑病患者のADAMTS13遺伝子に伏在していた変異の発見:ゲノムDNAを用いた定量PCR法の開発2013

    • Author(s)
      樋口(江浦)由佳,小亀浩市,松本雅則,藤村吉博,宮田敏行
    • Organizer
      第18回日本病態プロテアーゼ学会学術集会
    • Place of Presentation
      豊中
    • Data Source
      KAKENHI-PROJECT-25440060
  • [Presentation] 日本における先天性ADAMTS13欠損症の遺伝子解析2013

    • Author(s)
      樋口(江浦)由佳,小亀浩市,松本雅則,藤村吉博,宮田敏行
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-25440060
  • [Presentation] Quantitative PCR assay demonstrated exon deletions of ADAMTS13 in two unrelated patients with Upshaw-Schulman syndrome2013

    • Author(s)
      Yuka Eura, Koichi Kokame, Toshiro Takafuta, Ryojiro Tanaka, Hikaru Kobayashi, Fumihiro Ishida, Shuichi Hisanaga, Masanori Matsumoto, Yoshihiro Fujimura, and Toshiyuki Miyata
    • Organizer
      XXIV Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Amsterdam, The Netherlands
    • Data Source
      KAKENHI-PROJECT-25440060
  • [Presentation] ERAD複合体の構成因子はERストレスに応答してダイナミックに変化する2008

    • Author(s)
      江浦由佳
    • Organizer
      第81回日本生化学会大会, 第31回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-19570147
  • [Presentation] ERAD 複合体の構成因子はER ストレスに応答してダイナミックに変化する2008

    • Author(s)
      江浦由佳, 他
    • Organizer
      第81 回日本生化学会大会,第31 回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-19570147
  • [Presentation] Herp 欠損は小胞体ストレス誘導性のERAD 複合体形成を抑制する2007

    • Author(s)
      江浦由佳, 他
    • Organizer
      第80 回日本生化学会大会,第30 回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19570147
  • [Presentation] Herp欠損は小胞体ストレス誘導性のERAD複合体形成を抑制する2007

    • Author(s)
      江浦由佳
    • Organizer
      第80回日本生化学会大会,第30回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19570147
  • [Presentation] ダイレクトシークエンシング,定量PCR,次世代シークエンシングを用いたTTP患者の遺伝子解析

    • Author(s)
      樋口(江浦)由佳,小亀浩市,高蓋寿朗,田中亮二郎,小林光,石田文宏,久永修一,松本雅則,藤村吉博,宮田敏行
    • Organizer
      第36回日本血栓止血学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-29 – 2014-05-31
    • Data Source
      KAKENHI-PROJECT-25440060
  • [Presentation] デジタルPCRを用いたADAMTS13遺伝子変異のヘテロ接合性の解析

    • Author(s)
      小亀浩市,樋口(江浦)由佳,松本雅則,藤村吉博,宮田敏行
    • Organizer
      第36回日本血栓止血学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-29 – 2014-05-31
    • Data Source
      KAKENHI-PROJECT-25440060
  • 1.  KOKAME Koichi (40270730)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 17 results
  • 2.  秋山 正志 (30298179)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  NISHIMURA Takashi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  HONDA Shigenori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  Ikejima Hiroko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  松本 雅則
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  藤村 吉博
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  宮田 敏行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 9.  武輪 能明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  水野 敏秀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  巽 英介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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