HIGUCHI YUKA 樋口由佳 (江浦由佳)

… Alternative Names

樋口由佳ヒグチユカ

江浦由佳

EURA Yuka 江浦由佳

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Researcher Number	30443477
Other IDs
Affiliation (Current)	2023: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員
Affiliation (based on the past Project Information) *help	2023: 国立研究開発法人国立循環器病研究センター, その他部局等, 研究員 2022: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員 2017: 国立研究開発法人国立循環器病研究センター, 研究所, 研究員 2016: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員 2015: 国立研究開発法人国立循環器病研究センター, 研究所, 非常勤研究員 2007 – 2008: 国立循環器病センター研究所, 病因部, 流動研究員
Review Section/Research Field	Principal Investigator Functional biochemistry / Basic Section 53020:Cardiology-related Except Principal Investigator Functional biochemistry / Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator ERAD / ER stress / Derlin-3 / Herp / 小胞体関連分解 / 小胞体ストレス / Derlin Except Principal Investigator 小胞体 / 細胞情報伝達機構 / ストレス応答 … More / 酵素 / シグナル伝達 / ストレス / 蛋白質 / タンパク質品質管理 / プロリン異性化酵素 / ADAMTS13 / Siglec Less

心内膜特異的に発現するvon Willebrand因子の生理的意義と発現調節機構の解明Principal Investigator
- Principal Investigator
  
  樋口由佳 (江浦由佳)
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
血小板リガンドとSiglecの相互作用による好中球・単球の血栓形成促進機構の解明
- Principal Investigator
  
  秋山正志
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  National Cardiovascular Center Research Institute
Analysis of molecular mechanism of cell protective function of Derlin-3Principal Investigator
- Principal Investigator
  
  Eura Yuka
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Quality control of secretory proteins containing proline residues in the cis form
- Principal Investigator
  
  KOKAME KOICHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Research on protein quality control by the endoplasmic reticulum membrane proteins
- Principal Investigator
  
  KOKAME Koichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Cardiovascular Center Research Institute

All 2018 2017 2016 2015 2014 2013 2008 2007 Other

All Journal Article Presentation Book

[Book] 生化学2017
- Author(s)
  宮田敏行，樋口（江浦）由佳，杉本充彦
- Total Pages
  10
- Publisher
  公益社団法人　日本生化学会
- Data Source
  KAKENHI-PROJECT-15K18510
[Journal Article] Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca 2+ -calcineurin-Akt axis2018
- Author(s)
  Navarro-Marquez Mario、Torrealba Natalia、Troncoso Rodrigo、V?squez-Trincado Cesar、Rodriguez Marcelo、Morales Pablo E.、Villalobos Elisa、Eura Yuka、Garcia Lorena、Chiong Mario、Klip Amira、Jaimovich Enrique、Kokame Koichi、Lavandero Sergio
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  
  Volume: 1864 Pages: 1653-1662
- DOI
  10.1016/j.bbadis.2018.02.018
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07358, KAKENHI-PROJECT-15K18510
[Journal Article] Candidate gene analysis using genomic quantitative PCR: Identification of <i>ADAMTS13</i> large deletions in two patients with Upshaw-Schulman syndrome2017
- Author(s)
  Yuka Eura
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 28 Issue: 4 Pages: 537-542
- DOI
  10.2491/jjsth.28.537
- NAID
  130005966818
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18510
[Journal Article] Revised mechanisms of thrombus formation and next-generation anti-thrombotic strategy2017
- Author(s)
  Toshiyuki Miyata, Yuka Eura, Mitsuhiko Sugimoto
- Journal Title
  
  生化学
  
  Volume: 89 Issue: 3 Pages: 333-342
- DOI
  10.14952/SEIKAGAKU.2017.890333
- NAID
  40021265126
- ISSN
  0037-1017
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18510
[Journal Article] Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation2017
- Author(s)
  Torrealba Natalia、Navarro-Marquez Mario、Garrido Valeria、Pedrozo Zully、Romero Diego、Eura Yuka、Villalobos Elisa、Roa Juan Carlos、Chiong Mario、Kokame Koichi、Lavandero Sergio
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 13402-13402
- DOI
  10.1038/s41598-017-13797-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07358, KAKENHI-PROJECT-15K18510
[Journal Article] 先天性TTP（血栓性血小板減少性紫斑病）の遺伝子解析.2016
- Author(s)
  小亀浩市, 樋口(江浦)由佳.
- Journal Title
  
  血栓と循環
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18510
[Journal Article] Influence of a rotational speed modulation system used with an implantable continuous-flow left ventricular assist device on von Willebrand factor dynamics2016
- Author(s)
  Noritsugu Naito, Toshihide Mizuno, Takashi Nishimura, Satoru Kishimoto, Yoshiaki Takewa, Yuka Eura, Koichi Kokame, Toshiyuki Miyata, Kazuma Date, Akihide Umeki, Masahiko Ando, Minoru Ono, and Eisuke Tatsumi
- Journal Title
  
  Artificial Organs
  
  Volume: 未定 Pages: 877-883
- DOI
  10.1111/aor.12666
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25440060, KAKENHI-PROJECT-25560217, KAKENHI-PROJECT-25293294, KAKENHI-PROJECT-15K18510, KAKENHI-PROJECT-16K09834
[Journal Article] Genetic variations in complement factors in patients with congenital thrombotic thrombocytopenic purpura with renal insufficiency2016
- Author(s)
  Fan X, Kremer Hovinga JA, Shirotani-Ikejima H, Eura Y, Hirai H, Honda S, Kokame K, Taleghani MM, von Krogh AS, Yoshida Y, Fujimura Y, Lammle B, Miyata T
- Journal Title
  
  Int J Hematol.
  
  Volume: 103 Pages: 283-291
- DOI
  10.1007/s12185-015-1933-7
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09463, KAKENHI-PROJECT-25440060, KAKENHI-PROJECT-15K18510
[Journal Article] 先天性TTP（血栓性血小板減少性紫斑病）の遺伝子解析2016
- Author(s)
  樋口（江浦）由佳, 小亀浩市
- Journal Title
  
  血栓と循環
  
  Volume: 24
- Data Source
  KAKENHI-PROJECT-25440060
[Journal Article] Candidate gene analysis using genomic quantitative PCR: identification of ADAMTS13 large deletions in two patients with Upshaw-Schulman syndrome2014
- Author(s)
  Eura Y, Kokame K, Takafuta T, Tanaka R, Kobayashi H, Ishida F, Hisanaga S, Matsumoto M, Fujimura Y, Miyata T.
- Journal Title
  
  Molecular Genetics & Genomic Medicine
  
  Volume: 2 Pages: 240-244
- DOI
  10.1002/mgg3.64
- NAID
  130005966818
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23591425, KAKENHI-PROJECT-24390250, KAKENHI-PROJECT-25440060, KAKENHI-PROJECT-25461456
[Journal Article] ターゲット領域の異常を見逃さないゲノム定量PCR法の確立2014
- Author(s)
  樋口（江浦）由佳，小亀浩市，宮田敏行
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 25 Pages: 615-618
- Data Source
  KAKENHI-PROJECT-25440060
[Journal Article] Upshaw-Schulman症候群のADAMTS13遺伝子解析2014
- Author(s)
  小亀浩市，樋口（江浦）由佳
- Journal Title
  
  細胞
  
  Volume: 46 Pages: 61-63
- Data Source
  KAKENHI-PROJECT-25440060
[Journal Article] 小胞体逆輸送の謎にせまるin vitro アッセイ法2007
- Author(s)
  江浦由佳
- Journal Title
  
  蛋白質核酸酵素 52
  
  Pages: 1474-1475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] 小胞体関連分解におけるAAA-ATPase, p97 の役割2007
- Author(s)
  江浦由佳
- Journal Title
  
  蛋白質核酸酵素 52
  
  Pages: 74-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570147
[Presentation] Genetic, biochemical, and physiological approach to understanding the function of Herp and Derlin family proteins in ER-associated degradation machinery2017
- Author(s)
  Koichi Kokame and Yuka Eura
- Organizer
  ACCDiS Symposium 7 at XL Annual Meeting of the Chilean Society of Biochemistry and Molecular Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18510
[Presentation] 小胞体膜タンパク質Derlin-3は小胞体ストレスによる小胞体関連分解（ERAD）複合体の変化に必要である2016
- Author(s)
  樋口（江浦）由佳，池島裕子，宮田敏行，小亀浩市
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-15K18510
[Presentation] 植え込み型補助人工心臓が血中von Willebrand factorに与える影響に関する研究2015
- Author(s)
  水野敏秀, 内藤敬嗣, 樋口（江浦）由佳, 小亀浩市, 宮田敏行, 築谷朋典, 武輪能明, 巽英介
- Organizer
  第53回人工臓器学会大会
- Place of Presentation
  東京
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] 補助人工心臓による高分子量VWFマルチマーの減少は循環開始直後に始まる.2015
- Author(s)
  樋口(江浦)由佳，小亀浩市，水野敏秀，巽英介，宮田敏行.
- Organizer
  第37回日本血栓止血学会学術集会
- Place of Presentation
  甲府市
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K18510
[Presentation] 定常流型左室補助人工心臓に用いる自己心拍同期回転数制御システムがvon Willebrand factorに及ぼす影響2015
- Author(s)
  内藤敬嗣, 西村隆, 岸本諭, 水野敏秀, 武輪能明, 樋口（江浦）由佳, 小亀浩市, 宮田敏行, 小野稔, 巽英介
- Organizer
  第53回人工臓器学会大会
- Place of Presentation
  東京
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] 補助人工心臓装着による高分子量VWFマルチマーの減少は循環開始直後に始まる2015
- Author(s)
  樋口（江浦）由佳, 小亀浩市, 水野敏秀, 巽英介, 宮田敏行
- Organizer
  第37回日本血栓止血学会学術集会
- Place of Presentation
  甲府
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] Influence of a rotational speed modulation of an implantable continuous-flowleft ventricular assist device (EVAHEART) on von Willebrand factor dynamics2015
- Author(s)
  Noritsugu Naito, Toshihide Mizuno, Takashi Nishimura, Satoru Kishimoto, Yoshiaki Takewa, Yuka Eura, Koichi Kokame, Toshiyuki Miyata, Minoru Ono, and Eisuke Tatsumi
- Organizer
  The 23rd Annual Meeting of the International Society for Rotary Blood Pumps (ISRBP)
- Place of Presentation
  Dubrovnik
- Year and Date
  2015-09-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] 血栓性血小板減少性紫斑病患者のADAMTS13遺伝子に伏在していた変異の発見：ゲノムDNAを用いた定量PCR法の開発2013
- Author(s)
  樋口（江浦）由佳，小亀浩市，松本雅則，藤村吉博，宮田敏行
- Organizer
  第18回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  豊中
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] 日本における先天性ADAMTS13欠損症の遺伝子解析2013
- Author(s)
  樋口（江浦）由佳，小亀浩市，松本雅則，藤村吉博，宮田敏行
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] Quantitative PCR assay demonstrated exon deletions of ADAMTS13 in two unrelated patients with Upshaw-Schulman syndrome2013
- Author(s)
  Yuka Eura, Koichi Kokame, Toshiro Takafuta, Ryojiro Tanaka, Hikaru Kobayashi, Fumihiro Ishida, Shuichi Hisanaga, Masanori Matsumoto, Yoshihiro Fujimura, and Toshiyuki Miyata
- Organizer
  XXIV Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Amsterdam, The Netherlands
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] ERAD複合体の構成因子はERストレスに応答してダイナミックに変化する2008
- Author(s)
  江浦由佳
- Organizer
  第81回日本生化学会大会, 第31回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570147
[Presentation] ERAD 複合体の構成因子はER ストレスに応答してダイナミックに変化する2008
- Author(s)
  江浦由佳, 他
- Organizer
  第81 回日本生化学会大会,第31 回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19570147
[Presentation] Herp 欠損は小胞体ストレス誘導性のERAD 複合体形成を抑制する2007
- Author(s)
  江浦由佳, 他
- Organizer
  第80 回日本生化学会大会,第30 回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570147
[Presentation] Herp欠損は小胞体ストレス誘導性のERAD複合体形成を抑制する2007
- Author(s)
  江浦由佳
- Organizer
  第80回日本生化学会大会,第30回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570147
[Presentation] ダイレクトシークエンシング，定量PCR，次世代シークエンシングを用いたTTP患者の遺伝子解析
- Author(s)
  樋口（江浦）由佳，小亀浩市，高蓋寿朗，田中亮二郎，小林光，石田文宏，久永修一，松本雅則，藤村吉博，宮田敏行
- Organizer
  第36回日本血栓止血学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] デジタルPCRを用いたADAMTS13遺伝子変異のヘテロ接合性の解析
- Author(s)
  小亀浩市，樋口（江浦）由佳，松本雅則，藤村吉博，宮田敏行
- Organizer
  第36回日本血栓止血学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-25440060

1. KOKAME Koichi (40270730)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
2. 秋山正志 (30298179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. NISHIMURA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. HONDA Shigenori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. Ikejima Hiroko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 松本雅則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 藤村吉博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 宮田敏行

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
9. 武輪能明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 水野敏秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 巽英介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIGUCHI YUKA 樋口 由佳 (江浦 由佳)

樋口 由佳 ヒグチ ユカ

江浦 由佳

江浦由佳

EURA Yuka 江浦 由佳

Research Projects

Research Products

Co-Researchers

心内膜特異的に発現するvon Willebrand因子の生理的意義と発現調節機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

血小板リガンドとSiglecの相互作用による好中球・単球の血栓形成促進機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of molecular mechanism of cell protective function of Derlin-3Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Quality control of secretory proteins containing proline residues in the cis form

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on protein quality control by the endoplasmic reticulum membrane proteins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 生化学2017

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca 2+ -calcineurin-Akt axis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Candidate gene analysis using genomic quantitative PCR: Identification of <i>ADAMTS13</i> large deletions in two patients with Upshaw-Schulman syndrome2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Revised mechanisms of thrombus formation and next-generation anti-thrombotic strategy2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 先天性TTP（血栓性血小板減少性紫斑病）の遺伝子解析.2016

Author(s)

Journal Title

Data Source

[Journal Article] Influence of a rotational speed modulation system used with an implantable continuous-flow left ventricular assist device on von Willebrand factor dynamics2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic variations in complement factors in patients with congenital thrombotic thrombocytopenic purpura with renal insufficiency2016

Author(s)

HIGUCHI YUKA 樋口由佳 (江浦由佳)

樋口由佳ヒグチユカ

江浦由佳

EURA Yuka 江浦由佳