OKADA MUNEYOSHI 岡田宗善

… Alternative Names

岡田宗善オカダムネヨシ

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Researcher Number	30453509
Other IDs
Affiliation (Current)	2025: 北里大学, 獣医学部, 准教授
Affiliation (based on the past Project Information) *help	2025: 北里大学, 獣医学部, 准教授 2016 – 2023: 北里大学, 獣医学部, 准教授 2012 – 2015: 北里大学, 獣医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 42020:Veterinary medical science-related / Veterinary medical science / Basic veterinary science/Basic zootechnical science
Keywords	Principal Investigator 心肥大 / 心筋梗塞 / Matricryptins / 筋線維芽細胞 / 循環器・高血圧 / 細胞死 / 心筋細胞 / 心線維芽細胞 / IV型コラーゲン / 基底膜 … More / 糖尿病合併症 / 糖尿病 / 弁内皮細胞(VECs) / 伸展刺激 / 弁間質細胞(VICs) / IV型collagen / 粘液腫様僧帽弁疾患(MMVD) / Angiotensin II / 高血圧 / 心房筋 / Arresten / Extracellular matrix / カルシウムチャネル / カンスタチン / 心疾患 / 薬理学 / RNA干渉 / モノクロタリン / T型カルシウムチャネル / エンドスタチン / 心筋イオンチャネル / 心筋収縮 / 増殖 / 遊走 / 細胞遊走 / 細胞増殖 / Canstatin / Endostatin / 細胞外マトリックス / 心臓リモデリング / 循環器 Less

Research Projects
(6 results)
Research Products
(31 results)

糖尿病合併症における基底膜IV型コラーゲン由来matricryptinsの役割解明Principal Investigator
- Principal Investigator
  
  岡田宗善
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Kitasato University
粘液腫様僧帽弁疾患におけるmatricryptinsを介した新規発症機構解明Principal Investigator
- Principal Investigator
  
  岡田宗善
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Kitasato University
The role of arresten, a cleaved fragment of basement membrane type IV collagen alpha 1 chain, in the heartPrincipal Investigator
- Principal Investigator
  
  Okada Muneyoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Kitasato University
Elucidation of the role of canstatin, a cleaved fragment of type IV collagen, in the development of cardiac diseasePrincipal Investigator
- Principal Investigator
  
  Okada Muneyoshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Veterinary medical science
- Research Institution
  Kitasato University
Elucidation of the pathophysiological roles of endostatin in heart diseasePrincipal Investigator
- Principal Investigator
  
  OKADA MUNEYOSHI
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Kitasato University
Basic study on the role of matricryptins in cardiac remodelingPrincipal Investigator
- Principal Investigator
  
  OKADA MUNEYOSHI
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Kitasato University

All 2023 2022 2021 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Cathepsin S degrades arresten and canstatin in infarcted area after myocardial infarction in rats2019
- Author(s)
  Sugiyama A., Mitsui A., Okada M., Yamawaki H.
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 81 Issue: 4 Pages: 522-531
- DOI
  10.1292/jvms.18-0674
- NAID
  130007632956
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08028
[Journal Article] A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain2019
- Author(s)
  Okada M., Yamawaki H.
- Journal Title
  
  J. Pharmacol. Sci.
  
  Volume: 139 Issue: 2 Pages: 59-64
- DOI
  10.1016/j.jphs.2018.12.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08028
[Journal Article] Basement membrane-derived matricryptins as a new target molecule for heart failure treatment2018
- Author(s)
  岡田宗善、山脇英之
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 151 Issue: 3 Pages: 106-110
- DOI
  10.1254/fpj.151.106
- NAID
  130006470887
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08028
[Journal Article] Canstatin modulates L-type calcium channel activity in rat ventricular cardiomyocytes2018
- Author(s)
  Imoto K., Hirakawa M., Okada M., Yamawaki H.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 499 Issue: 4 Pages: 954-959
- DOI
  10.1016/j.bbrc.2018.04.026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08028
[Journal Article] New Insights into the Role of Basement Membrane-Derived Matricryptins in the Heart2017
- Author(s)
  Okada M., Imoto K., Sugiyama A., Yasuda J., Yamawaki H.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 12 Pages: 2050-2060
- DOI
  10.1248/bpb.b17-00308
- NAID
  130006235419
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08028
[Journal Article] Pathophysiological roles of canstatin on myofibroblasts after myocardial infarction in rats2017
- Author(s)
  Sugiyama A., Okada M., Yamawaki H.
- Journal Title
  
  Eur. J. Pharmacol.
  
  Volume: 807 Pages: 32-43
- DOI
  10.1016/j.ejphar.2017.04.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08028
[Journal Article] Canstatin inhibits hypoxia-induced apoptosis through activation of integrin/focal adhesion kinase/Akt signaling pathway in H9c2 cardiomyoblasts2017
- Author(s)
  Kanazawa H., Imoto K., Okada M. and Yamawaki H.
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 2 Pages: e0173051-e0173051
- DOI
  10.1371/journal.pone.0173051
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08028
[Journal Article] Endostatin is protective against monocrotaline-induced right heart disease through the inhibition of T-type Ca2+ channel2016
- Author(s)
  Imoto K., Kumatani S., Okada M. and Yamawaki H.
- Journal Title
  
  Pflugers Arch.
  
  Volume: 印刷中 Issue: 7 Pages: 1259-1270
- DOI
  10.1007/s00424-016-1810-0
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26850186
[Presentation] Transforming growth factor-β1および機械的伸展によるラット僧帽弁間質細胞の形質転換2023
- Author(s)
  岡田宗善、水井雅也、兒玉朋子、大谷紘資、山脇英之
- Organizer
  第74回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-22K06009
[Presentation] Expression and function of basement membrane-derived matricryptins in thickening of mitral valve in rats2022
- Author(s)
  岡田宗善、佐野功汰、鈴木竜之介、兒玉朋子、大谷紘資、山脇英之
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-22K06009
[Presentation] Expression of arresten and its role in the heart of rats with angiotensin II-induced hypertension2022
- Author(s)
  岡田宗善、栗原秀弥、森将就、大谷紘資、山脇英之
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K06428
[Presentation] IV型コラーゲンα1鎖分解断片arrestenがラット新生仔心筋細胞の酸化ストレス誘導性細胞死およびangiotensin II誘導性肥大に及ぼす影響2021
- Author(s)
  栗原秀弥、岡田宗善、大谷紘資、山脇英之
- Organizer
  第34回北里大学バイオサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-19K06428
[Presentation] Arresten, a cleaved fragment of type IV collagen α1 chain, regulates functions of cardiac fibroblasts and left atria2021
- Author(s)
  杉山彰、田嶋志帆、山本理幾、大谷紘資、岡田宗善、山脇英之
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K06428
[Presentation] Regulatory mechanisms for expression of matricryptins after myocardial infarction in rats2018
- Author(s)
  Sugiyama A., Mitsui A., Okada M., Yamawaki H.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology (WCP2018 Kyoto)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08028
[Presentation] Elucidation of the role of canstatin, a proteolytic fragment of extracellular matrix, in cardiac diseases2018
- Author(s)
  Okada M.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology (WCP2018 Kyoto)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08028
[Presentation] Effects of canstatin on L-type Ca2+ channel activity in rat ventricular cardiomyocytes2018
- Author(s)
  Imoto K., Hirakawa M., Okada M., Yamawaki H.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology (WCP2018 Kyoto)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08028
[Presentation] RNA干渉法によるcanstatin発現抑制がex vivoラット灌流心における冠動脈結紮による梗塞形成に及ぼす影響2018
- Author(s)
  伊藤　瑠美、杉山　彰、岡田　宗善、山脇　英之
- Organizer
  第31回北里大学バイオサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-16K08028
[Presentation] ラット心筋梗塞モデルにおけるmatricryptinsの発現動態とその調節機構について2017
- Author(s)
  三井　彩加、岡田　宗善、山脇　英之
- Organizer
  第30回北里大学バイオサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-16K08028
[Presentation] Molecular mechanisms underlying the canstatin-mediated inhibition of hypoxia-induced apoptosis in H9c2 cardiomyoblasts2017
- Author(s)
  岡田　宗善、金澤　礼樹、山脇　英之
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール、長崎新聞文化ホールアストピア（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K08028
[Presentation] ラット心室筋細胞のL型Ca2+チャネル活性制御におけるcanstatinの役割2017
- Author(s)
  平川　真樹、岡田　宗善、山脇　英之
- Organizer
  第30回北里大学バイオサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-16K08028
[Presentation] Canstatin regulates function of myofibroblasts after myocardial infarction2017
- Author(s)
  杉山　彰、岡田　宗善、山脇　英之
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール、長崎新聞文化ホールアストピア（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K08028
[Presentation] ラット心筋梗塞後の病変形成におけるIV型コラーゲン分解産物canstatinの役割解明2017
- Author(s)
  杉山　彰、伊藤　瑠美、岡田　宗善、山脇　英之
- Organizer
  第30回北里大学バイオサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-16K08028
[Presentation] ラット心筋梗塞モデル由来筋線維芽細胞機能に及ぼすcanstatinの影響2016
- Author(s)
  杉山　彰、岡田　宗善、山脇　英之
- Organizer
  第159回日本獣医学会学術集会
- Place of Presentation
  日本大学生物資源科学部（神奈川県藤沢市）
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-16K08028
[Presentation] Canstatinは低酸素誘導性H9c2細胞死を抑制する2016
- Author(s)
  金澤　礼樹、岡田　宗善、山脇　英之
- Organizer
  第159回日本獣医学会学術集会
- Place of Presentation
  日本大学生物資源科学部（神奈川県藤沢市）
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-16K08028
[Presentation] Effects of endostatin on T-type Ca2+ channel activity and pathogenesis of monocrotaline-induced right heart disease2016
- Author(s)
  井本圭亮、熊谷さやか、岡田宗善、山脇英之
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-26850186
[Presentation] モノクロタリン誘発肥大心のT型カルシウムチャネル活性に及ぼすXVIII型コラーゲン分解断片endostatinの影響2015
- Author(s)
  井本圭亮、熊谷さやか、岡田宗善、山脇英之
- Organizer
  第158回日本獣医学会学術集会
- Place of Presentation
  北里大学獣医学部（青森県十和田市）
- Year and Date
  2015-09-07
- Data Source
  KAKENHI-PROJECT-26850186
[Presentation] XVIII型コラーゲン分解断片endostatinは心筋梗塞領域の筋線維芽細胞機能を亢進する2015
- Author(s)
  岡田宗善、平野由佳、山脇英之
- Organizer
  第66回日本薬理学会北部会
- Place of Presentation
  富山国際会議場（富山県富山市）
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-26850186
[Presentation] Endostatin increases proliferation and migration of rat cardiac fibroblasts2014
- Author(s)
  岡田宗善、大場遥子、山脇英之
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  宮城県仙台市
- Year and Date
  2014-03-20
- Data Source
  KAKENHI-PROJECT-24780289
[Presentation] Canstatin increases matrix metalloproteinases secretion and cyclooxygenase-2 expression in rat cardiac fibroblasts2014
- Author(s)
  村田直紀、岡田宗善、山脇英之
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  宮城県仙台市
- Year and Date
  2014-03-20
- Data Source
  KAKENHI-PROJECT-24780289
[Presentation] Endostatinはマウス左心房筋のbradykinin誘発性収縮を抑制する2013
- Author(s)
  岡田宗善、高田璃羅、山脇英之
- Organizer
  第156回日本獣医学会学術集会
- Place of Presentation
  岐阜県岐阜市
- Year and Date
  2013-09-20
- Data Source
  KAKENHI-PROJECT-24780289
[Presentation] Endostatin Promotes Proliferation And Migration Of Rat Myofibroblasts Isolated From The Infarcted Area After Myocardial Infarction
- Author(s)
  Muneyoshi Okada, Yuka Hirano, and Hideyuki Yamawaki
- Organizer
  Basic Cardiovascular Sciences Scientific Sessions 2015
- Place of Presentation
  Hilton New Orleans Riverside, New Orleans, LA, USA
- Year and Date
  2015-07-13 – 2015-07-16
- Data Source
  KAKENHI-PROJECT-26850186

OKADA MUNEYOSHI 岡田 宗善

岡田 宗善 オカダ ムネヨシ

Research Projects

Research Products

糖尿病合併症における基底膜IV型コラーゲン由来matricryptinsの役割解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

粘液腫様僧帽弁疾患におけるmatricryptinsを介した新規発症機構解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of arresten, a cleaved fragment of basement membrane type IV collagen alpha 1 chain, in the heartPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the role of canstatin, a cleaved fragment of type IV collagen, in the development of cardiac diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the pathophysiological roles of endostatin in heart diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic study on the role of matricryptins in cardiac remodelingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Cathepsin S degrades arresten and canstatin in infarcted area after myocardial infarction in rats2019

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] A current perspective of canstatin, a fragment of type IV collagen alpha 2 chain2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Basement membrane-derived matricryptins as a new target molecule for heart failure treatment2018

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Canstatin modulates L-type calcium channel activity in rat ventricular cardiomyocytes2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New Insights into the Role of Basement Membrane-Derived Matricryptins in the Heart2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Pathophysiological roles of canstatin on myofibroblasts after myocardial infarction in rats2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Canstatin inhibits hypoxia-induced apoptosis through activation of integrin/focal adhesion kinase/Akt signaling pathway in H9c2 cardiomyoblasts2017

OKADA MUNEYOSHI 岡田宗善

岡田宗善オカダムネヨシ