TAKAI Hideki 高井英樹

Researcher Number	30453898
Other IDs
Affiliation *help	2015 – 2018 : 日本大学, 松戸歯学部, 講師 2015 : 日本大学, 松戸歯学部, 専任講師 2014 : 日本大学, 松戸歯学部, 助教 2012 – 2013 : 日本大学, 歯学部, 助教 2010 – 2011 : 日本大学, 松戸歯学部, 助教 2008 : 日本大学, 松戸歯学部, 助教
Review Section/Research Field	Principal Investigator Periodontology / Basic Section 57030:Conservative dentistry-related Except Principal Investigator Periodontology / Periodontal dentistry
Keywords	Principal Investigator 転写因子 / 歯周組織構成細胞 / miRNA / 分化誘導 Except Principal Investigator 転写調節 / 遺伝子発現 / 骨芽細胞 / 骨シアロタンパク質 / 転写因子 / 歯周組織再生 … More

Induction of differentiation of periodontal tissue constituent cells by regulating expression of miRNAPrincipal InvestigatorOngoing
- Principal Investigator
  
  高井英樹
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Nihon University
接合上皮発現タンパク質の発現制御による歯周病予防戦略Ongoing
- Principal Investigator
  
  小方頼昌
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Nihon University
Analysis of transcription factors involved in the differentiation induction of periodontal tissue constituent cellsPrincipal Investigator
- Principal Investigator
  
  TAKAI Hideki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontology
- Research Institution
  Nihon University
Mechanistic analysis of onset and progress of periodontitis causing microRNA
- Principal Investigator
  
  OGATA Yorimasa
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Nihon University
Analysis of involved specific transcription factor to differentiation Induction at periodontal tissue component cellsPrincipal Investigator
- Principal Investigator
  
  HIDEKI Takai
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontology
- Research Institution
  Nihon University
Mechanism of transcriptional regulation of extracellular matrix and transcription factors which control periodontal regeneration.
- Principal Investigator
  
  OGATA Yorimasa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Nihon University
Mechanism of gene expression of bone sialoprotein and transcription factors which control periodontal regeneration
- Principal Investigator
  
  OGATA Yorimasa
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Nihon University

All 2016 2015 2014 2013 2012 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Insulin-like growth factor-II regulates bone sialoprotein gene transcription.2016
- Author(s)
  Choe J, Sasaki Y, Zhou L, Takai H, Nakayama Y, Ogata Y
- Journal Title
  
  Odontology
  
  Volume : 104
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25463229
[Journal Article] Effects of periodontal initial therapy on interleukin-1β levels in gingival crevicular fluid and clinical periodontal parameters.2015
- Author(s)
  Oh H, Hirano J, Takai H, Ogata Y
- Journal Title
  
  J Oral Sci
  
  Volume : 57 Pages : 67-71
- DOI
  10.2334/josnusd.57.67
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25463229
[Journal Article] Transcriptional regulation of amelotin gene by proinflammatory cytokines in gingival fibroblasts.2014
- Author(s)
  Nakayama Y, Takai H, Matsui S, Zhou L, Abiko Y, Ganss B, Ogata Y.
- Journal Title
  
  Connect Tissue Res
  
  Volume : 55 Suppl 1 Pages : 18-20
- DOI
  10.3109/03008207.2014.923848
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25463229
[Journal Article] Unliganded estrogen receptor alpha stimulates bone sialoprotein gene expression.2014
- Author(s)
  H. Takai, H. Matsumura, S. Matsui, KM. Kim, M. Mezawa, Y. Nakayama, Y. Ogata
- Journal Title
  
  Gene
  
  Volume : 539 Pages : 50-57
- DOI
  10.1016/j.gene.2014.01.063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25463229
[Journal Article] Effects of interleukin-11 on the expression of human bone sialoprotein gene2014
- Author(s)
  H. Matsumura, Y. Nakayama, H. Takai, Y. Ogata
- Journal Title
  
  J Bone Miner Metab
  
  Volume : 32 Pages : 1-12
- DOI
  10.1007/s00774-014-0576-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25463229
[Journal Article] MicroRNA expression in inflamed and noninflamed gingival tissues from Japanese patients2014
- Author(s)
  Ogata Y, Matsui S, Kato A, Zhou L, Nakayama Y, Takai H
- Journal Title
  
  J Oral Sci
  
  Volume : 56 Pages : 253-260
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25463229
[Journal Article] Proinflammatory cytokines induce amelotin transcription in human gingival fibroblasts2014
- Author(s)
  Nakayama Y, Takai H, Matsui S, Matsumura H, Zhou L, Kato A, Bernhard Ganss B, Ogata Y
- Journal Title
  
  J Oral Sci
  
  Volume : 56 Pages : 262-268
- DOI
  10.2334/josnusd.56.261
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25463229
[Journal Article] Protamine stimulates bone sialoprotein gene expression.2013
- Author(s)
  Zhou L, Matsumura H, Mezawa M, Takai H, Nakayama Y, Mitarai M, Ogata Y.
- Journal Title
  
  Gene
  
  Volume : 516 Pages : 228-237
- DOI
  10.1016/j.gene.2012.12.056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592319
[Journal Article] Osteogenic transcription factors and proto-oncogene regulate bone sialoprotein gene transcription2013
- Author(s)
  H. Takai, M. Mezawa, J. Choe, Y. Nakayama, Y. Ogata
- Journal Title
  
  J Oral Science
  
  Volume : 55 Pages : 209-215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25463229
[Journal Article] Aggregatibacter actinomycetemcomitans lipopolysaccharide regulates bone sialoprotein gene transcription.2012
- Author(s)
  Li X, Zhou L, Takai H, Sasaki Y, Mezawa M, Li Z, Wang Z, Yang L, Wang S, Matsumura H, Kaneko T, Yoshimura A, Ogata Y.
- Journal Title
  
  Journal of Cell Biochemistry
  
  Volume : 113 Pages : 2822-2834
- DOI
  10.1002/jcb.24157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592319, KAKENHI-PROJECT-24593126
[Journal Article] Fibroblast growth factor 2 and forskolin induce mineralization-associated genes in two kinds of osteoblast-like cells.2012
- Author(s)
  Nakayama Y, Yang L, Takai H, Kaneko H, Abiko Y, Ogata Y.
- Journal Title
  
  J Oral Sci
  
  Volume : 54 Pages : 251-259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592319
[Journal Article] Regulation of human bone sialoprotein gene transcription by platelet-derived growth factor-BB2009
- Author(s)
  M. Mezawa, S. Araki, H. Takai, Y. Sasaki, S. Wang, X. Li, D. Kim, Y. Nakayama, Y. Ogata
- Journal Title
  
  Gene 435
  
  Pages : 80-87
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390563
[Journal Article] Parathyroid hormone regulation of the human bone sialoprotein gene transcription is mediated through two cAMP response elements2009
- Author(s)
  S. Araki, M. Mezawa, Y. Sasaki, L. Yang, Z. Li, H. Takai, Y. Nakayama, Y. Ogata
- Journal Title
  
  J. Cell. Biochem 106
  
  Pages : 618-625
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390563
[Journal Article] AP1 Binding Site is Another Target of FGF2 Regulation of Bone Sialoprotein Gene Transcription2008
- Author(s)
  H. Takai, S. Araki, M. Mezawa, D. Kim, X. Li, L. Yang, Z. Li, Z. Wang, Y. Nakayama and Y. Ogata
- Journal Title
  
  Gene 410
  
  Pages : 97-104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390563
[Journal Article] AP1 binding site is another target of FGF2 regulation of bone sialoprotein gene transcription.2008
- Author(s)
  Hideki Takai, et al.
- Journal Title
  
  Gene 410
  
  Pages : 97-104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390563
[Journal Article] Androgen receptor stimulates bone sialoprotein (BSP) gene transcription via CAMP response element and activator protein 1/Glucocorticoid response elements.2007
- Author(s)
  Takai Hideki, et al.
- Journal Title
  
  Journal of Cellular Biochemistry (印刷中)
- Data Source
  KAKENHI-PROJECT-18390563
[Journal Article] Effects of Quercetin and Quercetin 3-Glucuronide on the Expression of Bone Sialoprotein Gene2007
- Author(s)
  D. Kim, H. Takai, M. Arai, S. Araki, M. Mezawa, Y. Kawai, K. Murota, J. Terao and Y. Ogata
- Journal Title
  
  Journal of Cellular Biochemistry 101
  
  Pages : 790-800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390563
[Journal Article] 骨シアロタンパク質(BSP)遺伝子の転写に対するアンドドゲン受容体の効果2007
- Author(s)
  高井英樹, 小方頼昌
- Journal Title
  
  日本歯周誌 49
  
  Pages : 27-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390563
[Journal Article] Androgen Receptor Stimulates Bone Sialoprotein(BSP)Gene Transcription via cAMP Response Element and Activator Protein/Glucocorticoid Respose Element.2007
- Author(s)
  Hideki Takai, et. al.
- Journal Title
  
  Journal of Cellular Biochenistry 102
  
  Pages : 240-251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390563
[Journal Article] 骨シアロタンパク質(BSP)遺伝子の転写に対するアンドロゲン受容体の効果2007
- Author(s)
  高井英樹, 小方頼昌
- Journal Title
  
  日本歯周病学会会誌 49
  
  Pages : 27-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390563
[Journal Article] Androgen Receptor stimulates Bone Sialoprotein (BSP) Gene Transcription via cAMP response element and activator protein 1/glucocorticoid response elements2007
- Author(s)
  H. Takai, Y. Nakayama, D. Kim, M. Arai, S. Araki, M. Mezawa, Y. Nakajima, N. Kato, H. Masunaga and Y. Ogata
- Journal Title
  
  Journal of Cellular Biochemistry 102
  
  Pages : 240-251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390563
[Presentation] 歯周組織構成細胞関連転写因子の抑制による軟骨芽細胞への誘導2016
- Author(s)
  高井英樹
- Organizer
  第144回春季日本歯科保存学会
- Place of Presentation
  栃木県総合文化センター（栃木県・宇都宮）
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-15K20631
[Presentation] 歯周組織構成細胞関連転写因子の抑制による軟骨および間葉系幹細胞への誘導2016
- Author(s)
  高井英樹
- Organizer
  第59回秋季日本歯周病学会
- Place of Presentation
  朱鷺メッセ（新潟・新潟）
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-15K20631
[Presentation] Inhibition of periodontal tissue-related transcription factors induces differentiation of chondrocyte2016
- Author(s)
  Hideki Takai
- Organizer
  102nd Annual Meeting of the AAP
- Place of Presentation
  San Diego (America）
- Year and Date
  2016-09-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20631
[Presentation] 歯周組織構成細胞関連転写因子の抑制による軟骨芽細胞への誘導2015
- Author(s)
  高井英樹
- Organizer
  第58回秋季日本歯周病学会
- Place of Presentation
  アクトシティー浜松（静岡県・浜松市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K20631
[Presentation] 慢性歯周炎歯肉で発現が増加したmiR-223による炎症性サイトカイン発現の調節．2015
- Author(s)
  松井沙莉、高井英樹、小方頼昌
- Organizer
  第58回春季日本歯周病学会学術大会
- Place of Presentation
  幕張メッセ（千葉県千葉市）
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-25463229
[Presentation] Effects of miRNAs on the expression of inflammatory cytokines in human gingival fibroblasts.2015
- Author(s)
  Sari Matsui, Hideki Takai and Yorimasa Ogata
- Organizer
  EuroPerio8
- Place of Presentation
  London （England）
- Year and Date
  2015-06-03
- Data Source
  KAKENHI-PROJECT-25463229
[Presentation] Proinflammatory Cytokines Induce Amelotin Transcription in Human Gingival Fibroblasts.2013
- Author(s)
  Y. Nakayama, H. Takai, S. Matsui, L. Zhou, Y. Abiko, B. Ganss, Y. Ogata
- Organizer
  11th ICCBMT
- Place of Presentation
  Wisconsin, USA
- Data Source
  KAKENHI-PROJECT-25463229
[Presentation] Inhibition of stem cell-specific transcription factors induces differentiation of preosteoblasts.2013
- Author(s)
  Ｈ. Takai ＡＪ. van Wijnen, Y. Ogata
- Organizer
  IADR-APR 2013
- Place of Presentation
  Bangkok,Thailand
- Data Source
  KAKENHI-PROJECT-25463229
[Presentation] Melatonin Regulates Human Bone Sialoprotein Gene Transcription.2013
- Author(s)
  Ｈ. Matsumura, Y. Nakayama, H. Takai, Y. Ogata
- Organizer
  IADR-APR 2013
- Place of Presentation
  Bangkok,Thailand
- Data Source
  KAKENHI-PROJECT-25463229
[Presentation] Mitotic transcription factor circuits control the molecular phenotype of mesenchymal cells.2012
- Author(s)
  Hideki Takai
- Organizer
  Japanese Association for Dental Research
- Place of Presentation
  Niigata, Japan
- Data Source
  KAKENHI-PROJECT-22592319
[Presentation] Transcriptional Regulation of Bone Sialoprotein Gene by Aggregatibacter actinomycetemcomitans Lipopolysaccharide.2012
- Author(s)
  Ogata Y, Takai H, Zhou L, Matsumura H, Li X.
- Organizer
  IADR meeting
- Place of Presentation
  Brazil
- Data Source
  KAKENHI-PROJECT-22592319
[Presentation] Mitotic transcription factor circuits control the molecular phenotype of mesenchymal cells.2012
- Author(s)
  Takai H, van Wijnen AJ, Ogata Y.
- Organizer
  JADR meeting
- Place of Presentation
  Niigata
- Data Source
  KAKENHI-PROJECT-22592319
[Presentation] cAMP Regulates BSP Expression in Human Breast Cancer Cells2008
- Author(s)
  D. Kim, H. Takai, N. Kato, Y. Sasaki, S. Wang, Y. Nakayama, Y. Ogata
- Organizer
  IADR General Session
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-18390563
[Presentation] Androgen Receptor Regulates Bone Sialoprotein Gene Expression2008
- Author(s)
  H, Takai, Y, Nakayama, D, Kim, S, Araki, M, Mezawa, N, Kato, Y, Ogata
- Organizer
  IADR General Session
- Place of Presentation
  Toronto, Canada
- Data Source
  KAKENHI-PROJECT-18390563
[Presentation] Androgen Receptor Regulates Bone Sialoprotein Gene Expression.2008
- Author(s)
  Hideki Takai, et al.
- Organizer
  International Association for Dental Research
- Place of Presentation
  Toronto, Canada
- Year and Date
  2008-07-03
- Data Source
  KAKENHI-PROJECT-18390563
[Presentation] Regulation of human bone sialoprotein gene transcription by platelet-derived growth factor2007
- Author(s)
  M. Mezawa, S. Araki, D. Kim, H. Takai, Z. Wang, X. Li, N. Kato, Y.Nakayama, Y. Ogata
- Organizer
  9th International Conference of Chemistry and Biology of Mineralized Tissues
- Place of Presentation
  Austin USA
- Data Source
  KAKENHI-PROJECT-18390563
[Presentation] Insulin-like growth Factor-I regulates bone sialoprotein gene expression2007
- Author(s)
  Y. Nakayama, N. Kato, H. Takai, D. Kim, M. Arai, S. Araki, M.Mezawa, Y. Ogata
- Organizer
  9th International Conference of Chemistry and Biology of Mineralized Tissues
- Place of Presentation
  Austin USA
- Data Source
  KAKENHI-PROJECT-18390563
[Presentation] Regulation of Amelotin gene transcription by Proinflammatory Cytokines in Gingival Fibroblasts
- Author(s)
  Nakayama Y, Takai H, Matsui S, Zhou L, Abiko Y, Ganss B, Ogata Y
- Organizer
  54th General Session of Korean Academy of Periodontology
- Place of Presentation
  Seoul
- Year and Date
  2014-10-25 – 2014-10-26
- Data Source
  KAKENHI-PROJECT-25463229
[Presentation] Effects of Osteogenic Transcription Factors and Proto-oncogene on Bone Sialoprotein Gene Transcription
- Author(s)
  Takai H, Mezawa M, Nakayama Y, Ogata Y
- Organizer
  92nd General Session & Exhibition of the IADR
- Place of Presentation
  Cape Town, South Africa
- Year and Date
  2014-06-25 – 2014-06-28
- Invited
- Data Source
  KAKENHI-PROJECT-25463229

1. OGATA Yorimasa (90204065)

# of Collaborated Projects : 5results

# of Collaborated Products : 31results
2. NAKAYAMA Yohei (30434088)

# of Collaborated Projects : 3results

# of Collaborated Products : 19results
3. NAKAO Sumi (20102577)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
4. MASUNAGA Hiroshi (40229381)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
5. MATSUMURA Hiroyoshi

# of Collaborated Projects : 1results

# of Collaborated Products : 4results
6. MATSUI Sari

# of Collaborated Projects : 1results

# of Collaborated Products : 8results
7. KATO Ayako

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
8. 金子高士

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
9. 吉村篤利

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

TAKAI Hideki 高井 英樹

Research Projects

Research Products

Co-Researchers

Induction of differentiation of periodontal tissue constituent cells by regulating expression of miRNAPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

接合上皮発現タンパク質の発現制御による歯周病予防戦略Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of transcription factors involved in the differentiation induction of periodontal tissue constituent cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanistic analysis of onset and progress of periodontitis causing microRNA

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of involved specific transcription factor to differentiation Induction at periodontal tissue component cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of transcriptional regulation of extracellular matrix and transcription factors which control periodontal regeneration.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of gene expression of bone sialoprotein and transcription factors which control periodontal regeneration

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Insulin-like growth factor-II regulates bone sialoprotein gene transcription.2016

Author(s)

Journal Title

Data Source

[Journal Article] Effects of periodontal initial therapy on interleukin-1β levels in gingival crevicular fluid and clinical periodontal parameters.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcriptional regulation of amelotin gene by proinflammatory cytokines in gingival fibroblasts.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unliganded estrogen receptor alpha stimulates bone sialoprotein gene expression.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of interleukin-11 on the expression of human bone sialoprotein gene2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MicroRNA expression in inflamed and noninflamed gingival tissues from Japanese patients2014

Author(s)

Journal Title

Data Source

[Journal Article] Proinflammatory cytokines induce amelotin transcription in human gingival fibroblasts2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protamine stimulates bone sialoprotein gene expression.2013

TAKAI Hideki 高井英樹