MIYOSHI Kan 三好歓

Researcher Number	30454755
Affiliation (based on the past Project Information) *help	2014: 兵庫医科大学, 医学部, 助教 2008 – 2011: Hyogo College of Medicine, 医学部, 助教 2010: 兵庫医科大学, 学部, 助教
Review Section/Research Field	Principal Investigator General anatomy (including Histology/Embryology) / Anesthesiology Except Principal Investigator Orthopaedic surgery / Gastroenterology
Keywords	Principal Investigator TLR4 / glial interaction / astrocytes / spinal cord / neuropathic pain / microglia / IL-18 / IL-1β / astrocyte / caspase-1 / Caspase-1 / IL-18R … More Except Principal Investigator … More 坐骨神経痛 / 神経障害性疼痛 / グリア細胞 / MAPK / TLR4 / IL-18 / 脊椎脊髄病学 / TRPA1 / 疼痛 / 胃 / 内臓痛 / 迷走神経下神経節 / 後根神経節 / TAPA1 / 内蔵痛 / 上部消化管学(食道、胃、十二指腸) Less

脊髄リアルタイムイメージングを用いた神経障害性疼痛発現機序の時空間的解析Principal Investigator
- Principal Investigator
  
  三好歓
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology
- Research Institution
  Hyogo Medical University
Critical role for spinal caspase-1 in neuropathic pain development through its distinct regulation of cytokinesPrincipal Investigator
- Principal Investigator
  
  MIYOSHI Kan
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Hyogo Medical University
Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats
- Principal Investigator
  
  TANAKA Junji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hyogo Medical University
Glial activation in the spinal cord contributes to induction of sciatica
- Principal Investigator
  
  TACHIBANA Toshiya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Hyogo Medical University
IL-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injuryPrincipal Investigator
- Principal Investigator
  
  MIYOSHI Kan
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Hyogo College of Medicine

All 2012 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] Re-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation2012
- Author(s)
  Fukuoka T, Yamanaka H, Kobayashi K, Okubo M, Miyoshi K, Dai Y, Noguchi K
- Journal Title
  
  Pain
  
  Volume: 153 Issue: 1 Pages: 68-79
- DOI
  10.1016/j.pain.2011.09.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590798, KAKENHI-PROJECT-21591908, KAKENHI-PROJECT-21600016, KAKENHI-PROJECT-22300115, KAKENHI-PROJECT-22790195, KAKENHI-PUBLICLY-23116517, KAKENHI-PROJECT-24590737, KAKENHI-PROJECT-24659688
[Journal Article] Spinal 5-HT(3) receptor activation induces behavioral hypersensitivity via a neuronal-glial-neuronal signaling cascade2011
- Author(s)
  Gu M, Miyoshi K, Dubner R, Guo W, Zou S, Ren K, Noguchi K, Wei F.
- Journal Title
  
  J. Neurosci.
  
  Volume: 31 Issue: 36 Pages: 12823-12836
- DOI
  10.1523/jneurosci.1564-11.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590798, KAKENHI-PROJECT-21591908, KAKENHI-PROJECT-22790195
[Journal Article] Sleep disturbances in a neuropathic pain-like condition in the mouse are associated with altered GABAergic transmission in the cingulate cortex2011
- Author(s)
  Narita M, Niikura K, Nanjo-Niikura K, Narita M, Furuya M, Yamashita A, Saeki M, Matsushima Y, Imai S, Shimizu T, Asato M, Kuzumaki N, Okutsu D, Miyoshi K, Suzuki M, Tsukiyama Y, Konno M, Yomiya K, Matoba M, Suzuki T.
- Journal Title
  
  Pain
  
  Volume: 152 Issue: 6 Pages: 1358-1372
- DOI
  10.1016/j.pain.2011.02.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590798, KAKENHI-PROJECT-21591908, KAKENHI-PROJECT-22790195
[Journal Article] Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats2009
- Author(s)
  Kondo T, Obata K, Miyoshi, K., Sakurai J, Tanaka J, Miwa H, Noguchi K
- Journal Title
  
  Gut 58
  
  Pages: 1342-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890265
[Journal Article] Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury.2008
- Author(s)
  Miyoshi, K., et. al.
- Journal Title
  
  J. Neurosci. 28
  
  Pages: 12775-12787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890265
[Journal Article] Changes in the rewarding effects induced by tramadol and its active metabolite M1 after sciatic nerve injury in mice2008
- Author(s)
  Nakamura, A., Narita, M., Miyoshi, K., Shindo, K., Okutsu, D., Suzuki, M., Higashiyama, K., Suzuki, T
- Journal Title
  
  Psychopharmacology 200
  
  Pages: 307-316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890265
[Journal Article] Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury2008
- Author(s)
  Miyoshi, K., Obata, K., Kondo, T., Okamura, H., Noguchi, K
- Journal Title
  
  J. Neurosci 28
  
  Pages: 12775-12787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890265
[Journal Article] Synthesis of a novel 6, 14-epoxymorphinan derivative and its pharmacology2008
- Author(s)
  Nemoto, T., Fujii, H., Narita, M., Miyoshi, K., Nakamura, A., Suzuki, T., Nagase, H
- Journal Title
  
  Bioorg. Med. Chem. Lett 18
  
  Pages: 6398-6401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890265
[Journal Article] Syntheses of 4, 6'-epoxymorphinan derivatives and their pharmacologies2008
- Author(s)
  Nemoto, T., Fujii, H., Narita, M., Miyoshi, K., Nakamura, A., Suzuki, T., Nagase, H
- Journal Title
  
  Bioorg. Med. Chem 16
  
  Pages: 4304-4312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890265
[Journal Article] Comparative pharmacological profiles of morphine and oxycodone under a neuropathic pain-like state in mice: evidence for less sensitivity to morphine2008
- Author(s)
  Narita, M., Nakamura, A., Ozaki, M., Imai, S., Miyoshi, K., Suzuki, M., Suzuki, T
- Journal Title
  
  Neuropsychopharmacology 33
  
  Pages: 1097-1112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890265
[Presentation] Critical role for spinal IL-18/caspase-1 interaction in neuropathic pain development through its distinct regulation of interleukins2010
- Author(s)
  Miyoshi K, Noguchi K.
- Organizer
  World Congress on PAIN
- Place of Presentation
  Montreal, Canada
- Year and Date
  2010-08-30
- Data Source
  KAKENHI-PROJECT-21590798
[Presentation] 脊髄マイクログリアにおけるcaspase-1の発現増加とアロディニア2010
- Author(s)
  三好歓, 野口光一
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Year and Date
  2010-03-16
- Data Source
  KAKENHI-PROJECT-20890265
[Presentation] Critical role for spinal IL-18/caspase-1 interaction in neuropathic pain development through its distinct regulation of interleukins.2010
- Author(s)
  Miyoshi, K., et.al.
- Organizer
  13th World Congress on Pain (IASP)
- Place of Presentation
  Canada (montreal)
- Year and Date
  2010-08-30
- Data Source
  KAKENHI-PROJECT-22790195
[Presentation] Critical role for spinal IL-18/caspase-1 interaction in neuropathic pain development through its distinct regulation of interleukins2010
- Author(s)
  Miyoshi K, Noguchi K.
- Organizer
  World Congress on PAIN
- Place of Presentation
  Montreal, Canada
- Year and Date
  2010-08-30
- Data Source
  KAKENHI-PROJECT-21591908
[Presentation] Critical role for spinal IL-18/caspase-1 interaction in neuropathic pain development through its distinct regulation of interleukins2010
- Author(s)
  Miyoshi K, Noguchi K.
- Organizer
  World Congress on PAIN
- Place of Presentation
  Montreal, Canada
- Year and Date
  2010-08-30
- Data Source
  KAKENHI-PROJECT-22790195
[Presentation] 脊髄マイクログリアにおけるinterleukin-1β converting enzyme(ICE)の発現増加とアロディニア2009
- Author(s)
  三好歓, 他2名
- Organizer
  第31回日本疼痛学会
- Place of Presentation
  名古屋
- Year and Date
  2009-07-17
- Data Source
  KAKENHI-PROJECT-21590798
[Presentation] 脊髄マイクログリアにおけるICEの発現増加とアロディニア2009
- Author(s)
  三好歓, 小畑浩一, 野口光一
- Organizer
  第7回整形外科痛みを語る会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20890265
[Presentation] Interleukin-1β converting enzyme(ICE)upregulation in spinal glial cells contributes to tactile allodynia after nerve injury2009
- Author(s)
  Miyoshi K., et.al.
- Organizer
  The 39th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Chicago
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-21591908
[Presentation] 脊髄マイクログリア細胞におけるcaspase-1/IL-18シグナリングと神経障害性疼痛2009
- Author(s)
  小畑浩一, 三好歓, 野口光一
- Organizer
  第11回ORIGIN夏の神経科学ワークショップ
- Place of Presentation
  長野
- Data Source
  KAKENHI-PROJECT-20890265
[Presentation] 脊髄マイクログリアにおけるinterleukin-1 β converting enzyme(ICE)の発現増加とアロディニア2009
- Author(s)
  三好歓, 他2名
- Organizer
  第31回日本疼痛学会
- Place of Presentation
  名古屋
- Year and Date
  2009-07-17
- Data Source
  KAKENHI-PROJECT-20890265
[Presentation] Interleukin-1βconverting enzyme (ICE) upregulation in spinal glial cells contributes to tactile allodynia after nerve injury2009
- Author(s)
  Miyoshi, K., Obata K, Noguchi K
- Organizer
  The 39th Annual Meeting of the Society for Neuroscience (Neuroscience 2009)
- Place of Presentation
  Chicago, U.S. A
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-20890265
[Presentation] Interleukin-1β converting enzyme(ICE)upregulation in spinal glial cells contributes to tactile allodynia after nerve injury2009
- Author(s)
  Miyoshi K., et.al.
- Organizer
  The 39th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Chicago
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-21590798
[Presentation] 脊髄マイクログリアにおけるICEの発現増加とアロディニア2009
- Author(s)
  三好歓, 他2名
- Organizer
  第7回整形外科痛みを語る会
- Place of Presentation
  福岡
- Year and Date
  2009-07-04
- Data Source
  KAKENHI-PROJECT-21590798
[Presentation] 脊髄マイクログリアにおけるinterleukin-1βconverting enzyme(ICE)の発現増加とアロディニア2009
- Author(s)
  三好歓, 小畑浩一, 野口光一
- Organizer
  第31回日本疼痛学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20890265
[Presentation] 脊髄ミクログリアにおけるcaspase-1の発現増加は炎症性サイトカインの活性化を介して神経障害性疼痛の発症に関与する2009
- Author(s)
  三好歓, 野口光一
- Organizer
  第2回日本運動器疼痛研究会
- Place of Presentation
  東京
- Year and Date
  2009-11-07
- Data Source
  KAKENHI-PROJECT-20890265
[Presentation] 非傷害次知覚ニューロンにおけるretシグナリング増強と神経因性疼痛2009
- Author(s)
  小畑浩一, 三好歓, 野口光一
- Organizer
  第31回日本疼痛学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20890265
[Presentation] 脊髄ミクログリアにおけるcaspase-1の発現増加は炎症性サイトカインの活性化を介して神経障害性疼痛の発症に関与する2009
- Author(s)
  三好歓, 他1名
- Organizer
  第2回日本運動器疼痛研究会
- Place of Presentation
  東京
- Year and Date
  2009-11-07
- Data Source
  KAKENHI-PROJECT-21591908
[Presentation] 脊髄ミクログリアにおけるcaspase-1の発現増加は炎症性サイトカインの活性化を介して神経障害性疼痛の発症に関与する2009
- Author(s)
  三好歓, 他1名
- Organizer
  第2回日本運動器疼痛研究会
- Place of Presentation
  東京
- Year and Date
  2009-11-07
- Data Source
  KAKENHI-PROJECT-21590798
[Presentation] 脊髄マイクログリアにおけるICEの発現増加とアロディニア2009
- Author(s)
  三好歓, 他2名
- Organizer
  第7回整形外科痛みを語る会
- Place of Presentation
  福岡
- Year and Date
  2009-07-04
- Data Source
  KAKENHI-PROJECT-21591908
[Presentation] 脊髄マイクログリアにおけるinterleukin-1β convertingenzyme(ICE)の発現増加とアロディニア2009
- Author(s)
  三好歓, 他2名
- Organizer
  第31回日本疼痛学会
- Place of Presentation
  名古屋
- Year and Date
  2009-07-17
- Data Source
  KAKENHI-PROJECT-21591908
[Presentation] Interleukin-1 β converting enzyme(ICE)upregulation in spinal glial cells contributes to tactile allodynia after nerve injury2009
- Author(s)
  Miyoshi K., et.al.
- Organizer
  The 39th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Chicago
- Year and Date
  2009-10-20
- Data Source
  KAKENHI-PROJECT-20890265
[Presentation] IL-18-mediatecl microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury.2008
- Author(s)
  Miyoshi, K., et. al.
- Organizer
  The 38th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Washington D. C.
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-20890265
[Presentation] TRPA1 mediates gastric distension-induced visceral pain in rats2008
- Author(s)
  Kondo, T., Obata, K., Miyoshi, K., Sakurai, J., Miwa, H., Noguchi, k.
- Organizer
  The 38th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Washington D.C., U.S.A
- Data Source
  KAKENHI-PROJECT-20890265
[Presentation] IL-18を介した脊髄後角におけるマイクログリア・アストロト相互作用と神経因性疼痛2008
- Author(s)
  三好歓
- Organizer
  第10回ORIGIN神経科学研究会夏のワークショップ
- Place of Presentation
  宮崎
- Data Source
  KAKENHI-PROJECT-20890265
[Presentation] 脊髄マイクログリアにおの発現増加とアロディニア2008
- Author(s)
  三好歓, 小畑浩一, 野口光一
- Organizer
  第30回日本疼痛学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20890265
[Presentation] il-18を介した脊髄後角イクログリア・アストロサイト相互作用と神経因性疼痛2008
- Author(s)
  三好歓, 小畑浩一, 野口光一
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20890265
[Presentation] IL-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury2008
- Author(s)
  Miyoshi, K., Obata, K., Noguchi, K
- Organizer
  The 38th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Washington D.C., U.S.A
- Data Source
  KAKENHI-PROJECT-20890265
[Presentation] 神経因性疼痛における脊髄グリア細の役割2008
- Author(s)
  小畑浩一, 三好歓, 野口光一
- Organizer
  第6回整形外科痛みを語る会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-20890265

1. TANAKA Junji (90412022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. TACHIBANA Toshiya (40299095)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MIYOSHI Kan 三好 歓

Research Projects

Research Products

Co-Researchers

脊髄リアルタイムイメージングを用いた神経障害性疼痛発現機序の時空間的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Critical role for spinal caspase-1 in neuropathic pain development through its distinct regulation of cytokinesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Glial activation in the spinal cord contributes to induction of sciatica

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

IL-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Re-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Spinal 5-HT(3) receptor activation induces behavioral hypersensitivity via a neuronal-glial-neuronal signaling cascade2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sleep disturbances in a neuropathic pain-like condition in the mouse are associated with altered GABAergic transmission in the cingulate cortex2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats2009

Author(s)

Journal Title

Data Source

[Journal Article] Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury.2008

Author(s)

Journal Title

Data Source

[Journal Article] Changes in the rewarding effects induced by tramadol and its active metabolite M1 after sciatic nerve injury in mice2008

Author(s)

Journal Title

Data Source

[Journal Article] Interleukin-18-mediated microglia/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury2008

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of a novel 6, 14-epoxymorphinan derivative and its pharmacology2008

Author(s)

Journal Title

Data Source

[Journal Article] Syntheses of 4, 6'-epoxymorphinan derivatives and their pharmacologies2008

Author(s)

Journal Title

Data Source

[Journal Article] Comparative pharmacological profiles of morphine and oxycodone under a neuropathic pain-like state in mice: evidence for less sensitivity to morphine2008

Author(s)

Journal Title

Data Source

[Presentation] Critical role for spinal IL-18/caspase-1 interaction in neuropathic pain development through its distinct regulation of interleukins2010

Author(s)

Organizer

MIYOSHI Kan 三好歓