KOMURA Shingo 河村真吾

… Alternative Names

Komura Shingo 河村真吾

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Researcher Number	30456511
Other IDs	https://orcid.org/0000-0002-7639-7484
Affiliation (Current)	2026: 岐阜大学, 大学院医学系研究科, 特任講師
Affiliation (based on the past Project Information) *help	2026: 岐阜大学, 大学院医学系研究科, 特任講師 2022 – 2024: 岐阜大学, 大学院医学系研究科, 特任講師 2017 – 2023: 岐阜大学, 医学部附属病院, 助教 2020 – 2021: 岐阜大学, 大学院医学系研究科, 助教 2016: 岐阜大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 56020:Orthopedics-related / Orthopaedic surgery Except Principal Investigator Basic Section 56020:Orthopedics-related
Keywords	Principal Investigator 腱細胞 / 再生医療 / 腱再生医療 / Scx / PI3K/Akt / 腱損傷 / PI3K/Aktシグナル / 腱再生 / 再生治療 / 骨折 … More / シュワン細胞 / Sox10 / 骨再生 / 加齢 / αSMA / 筋線維芽細胞 / 腱 / 生態学 / 再生医学 / 遺伝子改変マウス / Tppp3 / 関節滑膜細胞 / 腱鞘滑膜細胞 … More Except Principal Investigator 嫌気性エネルギー代謝 / 遺伝子改変マウス / LDHA / 嫌気性代謝 / エネルギー代謝 / Wntシグナル / 末梢神経損傷 / PI3K/Aktシグナル / 末梢神経再生 / 未分化Schwann細胞 / Indian Hedgehog signal / 遠隔転移 / 骨肉腫 / CXCL14 / デュピュイトラン拘縮 / 創薬スクリーニング / ATACシークエンス / 次世代シークエンス / ラクチル化 / basigin / 乳酸 / 薬剤スクリーニング / Basigin / 軟骨 / Wnt/β-catenin　シグナル / PI3K/Akt シグナル / 脱分化 / Wnt /β-catenin シグナル / シグナル経路 / 骨新生 / アキレス腱付着部炎 / 脊椎関節炎モデルマウス / 付着部炎 / 脊椎関節炎 / ATP生合成 / 骨格 / ATP / 乳酸脱水素酵素A / 骨軟骨 / 嫌気性ATP生合成 / 好気性ATP生合成 / AMPK / Tfam / 嫌気性 / 好気性 / 骨軟骨形成 / ミトコンドリア / 骨格形成 / 再生医療 / iPS 細胞 / 未分化Schwann 細胞 Less

加齢による腱障害に対する新規概念「腱粗鬆症」の確立と新規分子標的治療の開発Principal Investigator
- Principal Investigator
  
  河村真吾
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Gifu University
Elucidation of PI3K/Akt Tendon Regeneration Signaling for Novel Tendon Regeneration TherapyPrincipal Investigator
- Principal Investigator
  
  Komura Shingo
- Project Period (FY)
  2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Gifu University
Functional analysis of anaerobic metabolism in cartilage and drug discovery for cartilage disorders
- Principal Investigator
  
  秋山治彦
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Gifu University
Wntシグナル-CXCL14に着目したデュピュイトラン拘縮の病態解明と新規治療方法の研究
- Principal Investigator
  
  平川明弘
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Gifu University
Inhibitory effect of anaerobic intracellular energy metabolism on osteosarcoma cell metastasis.
- Principal Investigator
  
  永野昭仁
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Gifu University
Development of a novel bone regeneration therapy targeting the intercellular signaling mechanisms of Schwann cells and mesenchymal bone-forming cellsPrincipal Investigator
- Principal Investigator
  
  Komura Shingo
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Gifu University
Discovery of novel signals related to enthesitis and bone formation in spondyloarthritis and their therapeutic application.
- Principal Investigator
  
  Tanaka Ryo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Gifu University
Identification of the pathway regulating schwann cells dedifferentiation and peripheral nerve regeneration via promoting immature schwann cells
- Principal Investigator
  
  Hirakawa Akihiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Gifu University
Investigation of new treatment of the peripheral nerve injury using of induced pluripotent stem cell induced immature Schwann cells
- Principal Investigator
  
  Hirakawa Akihiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Gifu University
Development of novel tendon regenerative therapy by elucidating the molecular mechanism that regulates native regenerative potential in tendons.Principal Investigator
- Principal Investigator
  
  Komura Shingo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Gifu University
The study for ATP biosynthesis in skeletal development and skeletal disorders
- Principal Investigator
  
  Akiyama Haruhiko
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Gifu University
Development of treatment methods of tendon diseases using genetically modified micePrincipal Investigator
- Principal Investigator
  
  Komura Shingo
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Gifu University

All 2025 2024 2023 2022 2021 2020 2019 2017 2016

All Journal Article Presentation

[Journal Article] PI3K-Akt signalling regulates Scx-lineage tenocytes and Tppp3-lineage paratenon sheath cells in neonatal tendon regeneration2025
- Author(s)
  Goto Atsushi、Komura Shingo、Kato Koki、Maki Rie、Hirakawa Akihiro、Aoki Hitomi、Tomita Hiroyuki、Taguchi Jumpei、Ozawa Manabu、Matsushima Takahide、Kishida Akio、Kimura Tsuyoshi、Asahara Hiroshi、Imai Yuuki、Yamada Yasuhiro、Akiyama Haruhiko
- Journal Title
  
  Nature Communications
  
  Volume: 16 Issue: 1 Pages: 3734-3734
- DOI
  10.1038/s41467-025-59010-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H05696, KAKENHI-PROJECT-23K21465
[Journal Article] C-X-C domain ligand 14-mediated stromal cell?macrophage interaction as a therapeutic target for hand dermal fibrosis2023
- Author(s)
  Goto Atsushi、Komura Shingo、Kato Koki、Maki Rie、Hirakawa Akihiro、Tomita Hiroyuki、Hirata Akihiro、Yamada Yasuhiro、Akiyama Haruhiko
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 1173-1173
- DOI
  10.1038/s42003-023-05558-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21465
[Journal Article] Induced pluripotent stem cell-derived tenocyte-like cells promote the regeneration of injured tendons in mice.2020
- Author(s)
  Komura S, Satake T, Goto A, Aoki H, Shibata H, Ito K, Hirakawa H, Yamada Y, Akiyama H
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 3992-3992
- DOI
  10.1038/s41598-020-61063-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16617
[Presentation] 成体マウスアキレス腱損傷におけるPI3k/Aktシグナルの役割の解明2024
- Author(s)
  加藤皓己　河村真吾　後藤篤史　秋山治彦
- Organizer
  第 39 回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-23K21465
[Presentation] PI3K/AktシグナルはTppp3 陽性腱鞘滑膜細胞を制御して生理的な腱再生を促す2024
- Author(s)
  後藤篤史、河村真吾、加藤皓己、富田弘之、青木仁美、田口純平、小沢学、今井祐記、山田泰広、秋山治彦
- Organizer
  第 39 回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-23K21465
[Presentation] 骨内に存在するSox10陽性細胞の解析2023
- Author(s)
  河村真吾、後藤篤史、加藤皓己、富田弘之、田口純平、小沢学、山田泰広、秋山治彦
- Organizer
  第41回日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-22K19583
[Presentation] 腱鞘を標識する遺伝子改変マウスの樹立2023
- Author(s)
  加藤皓己、河村真吾、後藤篤史、富田弘之、田口純平、小沢学、山田泰広、秋山治彦
- Organizer
  第 38 回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-23K21465
[Presentation] Cxcl14を介した間質細胞-マクロファージ間相互作用はデュピュイトラン拘縮の新規治療標的となりえる2023
- Author(s)
  河村真吾、後藤篤史、加藤皓己、槇利衣、平川明弘、富田弘之、平田暁大、山田泰広、秋山治彦
- Organizer
  第66回日本手外科学会学術集会
- Data Source
  KAKENHI-PROJECT-23K21465
[Presentation] Cxcl14を介した間質細胞-マクロファージ間相互作用はデュピュイトラン拘縮の新規治療標的となりえる2023
- Author(s)
  後藤篤史、河村真吾、加藤皓己、槇利衣、平川明弘、富田弘之、平田暁大、山田泰広、秋山治彦
- Organizer
  第 38 回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-23K21465
[Presentation] PI3K/Akt シグナルは腱再生における Scx 陽性細胞の遊走能と分化能に関与する2023
- Author(s)
  後藤篤史、河村真吾、加藤皓己、富田弘之、青木仁美、田口純平、小沢学、今井祐記、山田泰広、秋山治彦
- Organizer
  第 38 回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-23K21465
[Presentation] PI3K/Akt シグナルは腱再生における Scx 陽性細胞の遊走能と分化能に関与する2022
- Author(s)
  後藤篤史　河村真吾　平川明弘　富田弘之　田口純平　小沢学　山田泰広　秋山治彦
- Organizer
  第37回　日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-23K21465
[Presentation] 「腱再生とエイジング」2022
- Author(s)
  後藤篤史　河村真吾　平川明弘　富田弘之　田口純平　小沢学　山田泰広　秋山治彦
- Organizer
  第40回　日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-23K21465
[Presentation] PI3K/Akt シグナルは腱再生における Scx 陽性細胞の遊走能と分化能に関与する2022
- Author(s)
  後藤篤史　河村真吾　平川明弘　富田弘之　田口純平　小沢学　山田泰広　秋山治彦
- Organizer
  第40回　日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-23K21465
[Presentation] αSMA-CreERT2 BAC トランスジェニックマウスの作製2021
- Author(s)
  後藤篤史　河村真吾
- Organizer
  第36 回　日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-23K21465
[Presentation] マウスiPS細胞由来腱様細胞は腱損傷部の再生を促進する2021
- Author(s)
  河村真吾
- Organizer
  第94回　日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-23K21465
[Presentation] マウスiPS細胞由来腱様細胞は腱損傷部の再生を促進する2021
- Author(s)
  河村真吾　佐竹崇志　後藤篤史　青木仁美　柴田博史　伊藤謙治　平川明弘　山田泰広　秋山治彦
- Organizer
  第64回日本手外科学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16617
[Presentation] マウスiPS細胞由来腱様細胞は腱損傷部の再生を促進する2021
- Author(s)
  河村真吾
- Organizer
  第64回　日本手外科学会
- Data Source
  KAKENHI-PROJECT-23K21465
[Presentation] マウスiPS細胞由来腱様細胞は腱損傷部の再生を促進する2020
- Author(s)
  河村真吾　佐竹崇志　後藤篤史　青木仁美　柴田博史　伊藤謙治　平川明弘　山田泰広　秋山治彦
- Organizer
  第35回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-18K16617
[Presentation] マウスiPS細胞由来腱細胞は腱損傷部の再生に寄与する2019
- Author(s)
  河村真吾、佐竹崇志、平川明弘、秋山治彦、山田泰広
- Organizer
  第34回　日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-18K16617
[Presentation] Tppp3陽性腱鞘滑膜細胞は腱発生に寄与しうる2017
- Author(s)
  河村真吾　平川明弘　佐竹崇志　山田泰広　秋山治彦
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16H06845
[Presentation] 腱および腱周囲結合組織を標識する遺伝子改変マウスの樹立2016
- Author(s)
  河村真吾
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16H06845

1. Akiyama Haruhiko (60402830)

# of Collaborated Projects: 9 results

# of Collaborated Products: 11 results
2. Hirakawa Akihiro (50422720)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
3. Tanaka Ryo (70422722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 野澤聡 (20771679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 永野昭仁 (60422721)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Yamada Yasuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 淺原弘嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOMURA Shingo 河村 真吾

Komura Shingo 河村 真吾

Research Projects

Research Products

Co-Researchers

加齢による腱障害に対する新規概念「腱粗鬆症」の確立と新規分子標的治療の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of PI3K/Akt Tendon Regeneration Signaling for Novel Tendon Regeneration TherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of anaerobic metabolism in cartilage and drug discovery for cartilage disorders

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Wntシグナル-CXCL14に着目したデュピュイトラン拘縮の病態解明と新規治療方法の研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Inhibitory effect of anaerobic intracellular energy metabolism on osteosarcoma cell metastasis.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel bone regeneration therapy targeting the intercellular signaling mechanisms of Schwann cells and mesenchymal bone-forming cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Discovery of novel signals related to enthesitis and bone formation in spondyloarthritis and their therapeutic application.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of the pathway regulating schwann cells dedifferentiation and peripheral nerve regeneration via promoting immature schwann cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of new treatment of the peripheral nerve injury using of induced pluripotent stem cell induced immature Schwann cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel tendon regenerative therapy by elucidating the molecular mechanism that regulates native regenerative potential in tendons.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The study for ATP biosynthesis in skeletal development and skeletal disorders

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of treatment methods of tendon diseases using genetically modified micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] PI3K-Akt signalling regulates Scx-lineage tenocytes and Tppp3-lineage paratenon sheath cells in neonatal tendon regeneration2025

Author(s)

Journal Title

KOMURA Shingo 河村真吾

Komura Shingo 河村真吾