Tuchiya Yoshiki 土谷佳樹

… Alternative Names

土谷佳樹ツチヤヨシキ

Tsuchiya Yoshiki 土谷佳樹

TSUCHIYA Yoshiki 土谷佳樹

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Researcher Number	30456777
Other IDs
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 講師
Affiliation (based on the past Project Information) *help	2023: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2015 – 2020: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2012 – 2013: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2008 – 2011: Doshisha University, 生命医科学部, 助教
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Basic Section 43010:Molecular biology-related / Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related / Constructive Systems Biology / Environmental physiology(including physical medicine and nutritional physiology) / Functional biochemistry Except Principal Investigator General medical chemistry / Biological Sciences
Keywords	Principal Investigator 概日リズム / 転写フィードバックループ / 脂質 / シグナル伝達 / 代謝異常学 / 細胞内局在制御 / タンパク質間相互作用 / 時計タンパク質 / 発生 / 体内時計 … More / 核内受容体 / 人工遺伝子回路 / 人工転写因子 / 温度補償性 / ES細胞 / 細胞・組織 / 転写因子 / 蛋白質 / 脂質代謝 … More Except Principal Investigator タンパク質分解 / ストレス / ユビキチン / タンパク質構造 / センサー / 酸化ストレス / 転写制御 / 蛋白質 / シグナル伝達 / ストレス応答 / プロテアソーム / タンパク質分解機構 / 遺伝子発現制御 / 脂質代謝異常 / 遺伝子発現制 / 遺伝子破壊マウス / 脂質代謝 / ストレス感知 Less

Regulatory Mechanisms of Clock Protein Dynamics in Mammalian Circadian Clock DevelopmentPrincipal Investigator
- Principal Investigator
  
  土谷佳樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Function of REV-ERBa/b in regulation of cellular circadian physiologyPrincipal Investigator
- Principal Investigator
  
  Tsuchiya Yoshiki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Understanding of the mechanism underlying gene expression rhythms using a gene circuit model with engineered Cas9 transcription factorsPrincipal Investigator
- Principal Investigator
  
  Tsuchiya Yoshiki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Constructive Systems Biology
- Research Institution
  Kyoto Prefectural University of Medicine
Identification of temperature compensation mechanisms in the mammalian circadian clockPrincipal Investigator
- Principal Investigator
  
  Tsuchiya Yoshiki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology(including physical medicine and nutritional physiology)
- Research Institution
  Kyoto Prefectural University of Medicine
Epigenetic regulation of circadian clock development during ES cell differentiationPrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Yoshiki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Kyoto Prefectural University of Medicine
Advanced investigation of molecular regulation of lipid metabolism by the transcription factor Nrf1
- Principal Investigator
  
  KOBAYASHI Akira
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Doshisha University
Phosphorylation-mediated regulation of Nrf1 in the pathogenesis of steatohepatitisPrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Yoshiki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Doshisha University
A role of Nrf1 in the regulation of lipid metabolismPrincipal Investigator
- Principal Investigator
  
  TSUCHIYA Yoshiki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Doshisha University
タンパク質分解制御による酸化ストレス応答機構の解明
- Principal Investigator
  
  KOBAYASHI Akira
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Doshisha University
  Tohoku University
酸化ストレスセンサーKeap1のストレス応答機構
- Principal Investigator
  
  小林聡
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Doshisha University
  Tohoku University
Physiological roles of the transcription factor Nrf1 on the lipid metabolism
- Principal Investigator
  
  KOBAYASHI Akira
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Doshisha University
  Tohoku University

All 2020 2019 2018 2016 2015 2011 2010 2008

All Journal Article Presentation Book

[Book] 最新臨床睡眠学（第2版）睡眠障害の基礎と臨床2020
- Author(s)
  土谷佳樹，八木田和弘
- Total Pages
  770
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-18K06338
[Journal Article] Circadian clock and cancer: From a viewpoint of cellular differentiation2020
- Author(s)
  Tsuchiya Yoshiki, Umemura Yasuhiro, Yagita Kazuhiro
- Journal Title
  
  International Journal of Urology
  
  Volume: － Issue: 6 Pages: 518-524
- DOI
  10.1111/iju.14231
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22516, KAKENHI-PROJECT-18H02600, KAKENHI-PROJECT-19K06679, KAKENHI-PROJECT-18K06338
[Journal Article] REV-ERBα and REV-ERBβ function as key factors regulating Mammalian Circadian Output2019
- Author(s)
  Ikeda Ryosuke、Tsuchiya Yoshiki、Koike Nobuya、Umemura Yasuhiro、Inokawa Hitoshi、Ono Ryutaro、Inoue Maho、Sasawaki Yuh、Grieten Tess、Okubo Naoki、Ikoma Kazuya、Fujiwara Hiroyoshi、Kubo Toshikazu、Yagita Kazuhiro
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 10171-10171
- DOI
  10.1038/s41598-019-46656-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06338, KAKENHI-PROJECT-18K09040, KAKENHI-PROJECT-19K06679, KAKENHI-PROJECT-19K22516, KAKENHI-PROJECT-18K16629, KAKENHI-PROJECT-18H02600
[Journal Article] Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth.2019
- Author(s)
  Oshima T, Niwa Y, Kuwata K, Srivastava A, Hyoda T, Tsuchiya Y, Kumagai M, Tsuyuguchi M, Tamaru T, Sugiyama A, Ono N, Zolboot N, Aikawa Y, Oishi S, Nonami A, Arai F, Hagihara S, Yamaguchi J, Tama F, Kunisaki Y, Yagita K, Ikeda M, Kinoshita T, Kay SA, Itami K, Hirota T.
- Journal Title
  
  Science Advance
  
  Volume: 23 Issue: 1 Pages: 9060-9060
- DOI
  10.1126/sciadv.aau9060
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06338, KAKENHI-PROJECT-18K19171, KAKENHI-PLANNED-26119006, KAKENHI-PROJECT-16H04148, KAKENHI-PROJECT-17H04208, KAKENHI-PROJECT-18H02402, KAKENHI-PROJECT-18H02600, KAKENHI-PROJECT-16J04435, KAKENHI-PROJECT-16KT0175, KAKENHI-PROJECT-19K07288, KAKENHI-PLANNED-17H06350, KAKENHI-PUBLICLY-18H04428, KAKENHI-PROJECT-18H02841, KAKENHI-PROJECT-16K15193
[Journal Article] Effect of Multiple clock gene ablations on the circadian period-length and temperature compensation in mammalian cells.2016
- Author(s)
  Tsuchiya Y., Umemura Y., Minami Y., Koike N., Hosokawa T., Hara M., Ito H., Inokawa H. & Yagita K.
- Journal Title
  
  Journal of Biological Rhythms
  
  Volume: 31 Issue: 1 Pages: 48-56
- DOI
  10.1177/0748730415613888
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08212, KAKENHI-PROJECT-26350697, KAKENHI-PROJECT-26650121, KAKENHI-PROJECT-16H01880, KAKENHI-PROJECT-15H04683
[Journal Article] Disruption of MeCP2 attenuates circadian rhythm in CRISPR/Cas9-based Rett syndrome model mouse.2015
- Author(s)
  Tsuchiya Y., Minami Y., Umemura Y., Watanabe H., Ono D., Nakamura W., Takahashi T., Honma S., Kondoh G., Matsuishi T. & Yagita K.
- Journal Title
  
  Genes to Cells
  
  Volume: 20 Issue: 12 Pages: 992-1005
- DOI
  10.1111/gtc.12305
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08212, KAKENHI-PROJECT-15K09608, KAKENHI-PROJECT-26462809, KAKENHI-PROJECT-15K21098, KAKENHI-PROJECT-26860156, KAKENHI-PLANNED-24119004, KAKENHI-PROJECT-25250012, KAKENHI-PROJECT-15H04683, KAKENHI-PROJECT-25461568
[Journal Article] Dual Regulation of the Transcriptional Activity of Nrf1 by β-TrCP-and Hrd1-Dependent Degradation Mechanisms2011
- Author(s)
  Tsuchiya Y, Morita T, Kim M, Iemura SI, Natsume T, Yamamoto M, Kobayashi A
- Journal Title
  
  Mol Cell Biol
  
  Volume: 31 Issue: 22 Pages: 4500-4512
- DOI
  10.1128/mcb.05663-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-22590277, KAKENHI-PROJECT-22790329
[Journal Article] Dual regulation of the transcriptional activity of Nrf1 by β-TrCP-and Hrd1-dependent degradation mechanisms2011
- Author(s)
  Tsuchiya, Y., Morita, T., Kim, M., Iemura, S., Natsume, T., Yamamoto, M. and Kobayashi, A.
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: 31 Pages: 4500-4512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590277
[Journal Article] Down-regulation of the PI3-kinase/Akt pathway by ERK MAP kinase in growth factor signaling2008
- Author(s)
  Hayashi H, Tsuchiya Y, Nakayama K, Satoh T, Nishida E.
- Journal Title
  
  Genes Cells 13
  
  Pages: 941-947
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590268
[Presentation] 時計遺伝子ノックアウトES細胞を用いた哺乳類概日時計制御機構の解析2019
- Author(s)
  土谷佳樹
- Organizer
  日本ゲノム編集学会第4回大会
- Data Source
  KAKENHI-PROJECT-16KT0175
[Presentation] The Role of REV-ERBs as Key Factors of Circadian Output.2018
- Author(s)
  Yoshiki Tsuchiya
- Organizer
  International Symposium on Biological Rhythms ~20 years since Discovery of Mammalian Clock Genes~
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06338
[Presentation] The Role of REV-ERBs as Key Factors of Circadian Output.2018
- Author(s)
  Yoshiki Tsuchiya
- Organizer
  International Symposium on Biological Rhythms ~20 years since Discovery of Mammalian Clock Genes~
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0175
[Presentation] The CRISPR/Cas9-mediated disruption of clock genes in mouse ES cells.2015
- Author(s)
  土谷佳樹
- Organizer
  第22回日本時間生物学会学術大会
- Place of Presentation
  東京
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-15K08212
[Presentation] Dual Regulation of the Transcription Factor Nrf1(Nfe2l1) by β-TrCP-And Hrd1-Dependent Degradation Mechanisms2011
- Author(s)
  Tsuchiya Y, Morita T, Kim M, Iemura S, Natsume T, Yamamoto M, Kobayashi A
- Organizer
  EMBO Workshop on Intracellular Proteolysis & Cancer
- Place of Presentation
  スペイン,バレンシア
- Year and Date
  2011-10-26
- Data Source
  KAKENHI-PROJECT-22790329
[Presentation] Dual regulation of the transcriptional activity of Nrf1 by β-TrCP-and Hrd1-dependent degradation mechanisms2011
- Author(s)
  土谷佳樹, 森田智子, 金美姫, 家村俊一郎, 夏目徹, 山本雅之, 小林聡
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590277
[Presentation] Dual regulation of the transcription factor Nrf1(Nfe2l1) by β-TrCP-and Hrd1-dependent degradation mechanisms2011
- Author(s)
  Tsuchiya, Y., Morita, T., Kim, M., Iemura, S., Natsume, T., Yamamoto, M., and Kobayashi, A.
- Organizer
  EMBO Workshop on Intracellular Proteolysis and Cancer
- Place of Presentation
  Valencia, Spain
- Data Source
  KAKENHI-PROJECT-22590277
[Presentation] CK2 regulates the transcriptional activity of Nrf1 to maintain cellular homeostasis2011
- Author(s)
  伊藤義起, 土谷佳樹, 家村俊一郎, 夏目徹, 小林聡
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590277
[Presentation] Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms2011
- Author(s)
  土谷佳樹
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22590277
[Presentation] Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms2011
- Author(s)
  Yoshiki Tsuchiya
- Organizer
  EMBO workshop on Intracellular Proteolysis & Cancer
- Place of Presentation
  Red Sea Mar Rojo Auditorium (Valencia, Spain)
- Year and Date
  2011-10-27
- Data Source
  KAKENHI-PROJECT-22590277
[Presentation] Dual regulation of the transcriptional activity of Nrf1 by β-TrCP-and Hrd1-dependent degradation mechanisms2011
- Author(s)
  Tsuchiya Y, Morita T, Kim M, Iemura S, Natsume T, Yamamoto M, Kobayashi A
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22790329
[Presentation] Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms2011
- Author(s)
  Yoshiki Tsuchiya
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22790329
[Presentation] Cytoplasmic and nuclear degradation mechanisms regulate biological function of transcription factor Nrf1.2010
- Author(s)
  Tomoko Morita, Yoshiki Tsuchiya, Mehee Kim, Shun-ichiro Iemura, Takako Tsukide, Akiko Matsumoto, Tohru Natsume, Akira Kobayashi
- Organizer
  10遺伝情報DECODE・冬のワークショップ
- Place of Presentation
  新潟, 湯沢
- Year and Date
  2010-01-18
- Data Source
  KAKENHI-PROJECT-20790252
[Presentation] The role of CK2 in the regulation of the mammalian circadian rhythms2010
- Author(s)
  Yoshiki Tsuchiya
- Organizer
  6^<th> International Conference on Protein Kinase CK2
- Place of Presentation
  Wahn Castle, Cologne, Germany
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-22790329
[Presentation] リン酸化による転写因子Nrf1の機能制御機構解析2010
- Author(s)
  伊藤義起, 土谷佳樹, 家村俊一郎, 夏目徹, 小林聡
- Organizer
  分子生物学会第10回春季シンポジウム
- Place of Presentation
  松島,宮城
- Data Source
  KAKENHI-PROJECT-22590277
[Presentation] Cytoplasmic and nuclear degradation mechanisms regulate biological function of the transcription factor Nrf12010
- Author(s)
  Morita, T., Tsuchiya, Y., Kim, M., Iemura, S., Tsukide, T., Natsume, T., Yamamoto, M., and Kobayashi, A.
- Organizer
  第33回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590277
[Presentation] CK2 regulates the transcription factor Nrf1 to maintain cellular homeostasis2010
- Author(s)
  Ito, Y., Tsuchiya, Y., Iemura, S., Natsume, T., and Kobayashi, A.
- Organizer
  6th International Conference on Protein Kinase CK2
- Place of Presentation
  Cologne, Germany
- Data Source
  KAKENHI-PROJECT-22590277

1. KOBAYASHI Akira (50292214)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
2. YAGITA Kazuhiro (90324920)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 山本雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tuchiya Yoshiki 土谷 佳樹

土谷 佳樹 ツチヤ ヨシキ

Tsuchiya Yoshiki 土谷 佳樹

TSUCHIYA Yoshiki 土谷 佳樹

Research Projects

Research Products

Co-Researchers

Regulatory Mechanisms of Clock Protein Dynamics in Mammalian Circadian Clock DevelopmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Function of REV-ERBa/b in regulation of cellular circadian physiologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding of the mechanism underlying gene expression rhythms using a gene circuit model with engineered Cas9 transcription factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of temperature compensation mechanisms in the mammalian circadian clockPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Epigenetic regulation of circadian clock development during ES cell differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Advanced investigation of molecular regulation of lipid metabolism by the transcription factor Nrf1

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Phosphorylation-mediated regulation of Nrf1 in the pathogenesis of steatohepatitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A role of Nrf1 in the regulation of lipid metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

タンパク質分解制御による酸化ストレス応答機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

酸化ストレスセンサーKeap1のストレス応答機構

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Physiological roles of the transcription factor Nrf1 on the lipid metabolism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 最新臨床睡眠学（第2版）睡眠障害の基礎と臨床2020

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Circadian clock and cancer: From a viewpoint of cellular differentiation2020

Author(s)

Tuchiya Yoshiki 土谷佳樹

土谷佳樹ツチヤヨシキ

Tsuchiya Yoshiki 土谷佳樹

TSUCHIYA Yoshiki 土谷佳樹