ASAI AKIRA 浅井明

… Alternative Names

Asai Akira 浅井明

ASAI Akira 浅井明

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Researcher Number	30500011
Other IDs
Affiliation (Current)	2025: 日本医科大学, 大学院医学研究科, 研究生
Affiliation (based on the past Project Information) *help	2021 – 2023: 日本医科大学, 大学院医学研究科, 研究生 2016 – 2019: 東北大学, 農学研究科, 特任准教授 2017: 東北大学, (連合)農学研究科(研究院), 准教授 2015: 東北大学, (連合)農学研究科(研究院), 准教授 2014: 日本医科大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Experimental pathology / Basic Section 38050:Food sciences-related Except Principal Investigator Basic Section 49030:Experimental pathology-related
Keywords	Principal Investigator 糖尿病 / 脂肪酸 / インスリン分泌 / 膵島 / 脂肪毒性 / β細胞 / モデルマウス / EndoC-βH1 / 膵β細胞 / 2型糖尿病 … More / CD36 / ヒト / モデル動物 / ヒト膵島 / 血糖値変動 / 動脈硬化 / 耐糖能異常 … More Except Principal Investigator 膵β細胞 / インスリン分泌不全 / 2型糖尿病 / 膵ランゲルハンス島 / インスリン分泌機構 / 糖尿病 / Oikawa-Nagaoマウス / CD36 / インスリン分泌 / β細胞 Less

New pathophysiology of type 2 diabetes: Altered beta-cell CD36 expression and impaired insulin secretion
- Principal Investigator
  
  長尾元嗣
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Nippon Medical School
Nutritional physiology of lipoadaptation/lipotoxicity in pancreatic beta cells in the development of type 2 diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  Asai Akira
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Nippon Medical School
Fatty acid dynamics as insulin secretion capacity regulating factor: analysis in human isletsPrincipal Investigator
- Principal Investigator
  
  Asai Akira
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  Experimental pathology
- Research Institution
  Tohoku University
Fatty acid dynamics as insulin secretion capacity regulating factor: analysis in new model micePrincipal Investigator
- Principal Investigator
  
  Asai Akira
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tohoku University
Impaired glucose tolerance as a risk factor for arteriosclerotic disease: analysis in new model micePrincipal Investigator
- Principal Investigator
  
  ASAI Akira
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tohoku University
  Nippon Medical School

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Selectively bred rodent models for studying the etiology of type 2 diabetes: Goto-Kakizaki rats and Oikawa-Nagao mice2023
- Author(s)
  Nagao Mototsugu、Asai Akira、Eliasson Lena、Oikawa Shinichi
- Journal Title
  
  Endocr J
  
  Volume: 70 Issue: 1 Pages: 19-30
- DOI
  10.1507/endocrj.EJ22-0253
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05453, KAKENHI-PROJECT-22K07008
[Journal Article] Selectively Bred Diabetes Models: GK Rats, NSY Mice, and ON Mice2020
- Author(s)
  Nagao Mototsugu、Esguerra Jonathan Lou S.、Wendt Anna、Asai Akira、Sugihara Hitoshi、Oikawa Shinichi、Eliasson Lena
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2128 Pages: 25-54
- DOI
  10.1007/978-1-0716-0385-7_3
- ISBN
  9781071603840, 9781071603857
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08780, KAKENHI-PROJECT-17KK0184, KAKENHI-PROJECT-19K23872
[Journal Article] Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells2020
- Author(s)
  Nagao Mototsugu、Esguerra Jonathan L.S.、Asai Akira、Ofori Jones K.、Edlund Anna、Wendt Anna、Sugihara Hitoshi、Wollheim Claes B.、Oikawa Shinichi、Eliasson Lena
- Journal Title
  
  Diabetes
  
  Volume: in press Issue: 6 Pages: 1193-1205
- DOI
  10.2337/db19-0944
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08780, KAKENHI-PROJECT-17KK0184, KAKENHI-PROJECT-19K23872
[Journal Article] Leptin production capacity determines food intake and susceptibility to obesity-induced diabetes in Oikawa-Nagao Diabetes-Prone and Diabetes-Resistant mice2020
- Author(s)
  Asai Akira、Nagao Mototsugu、Hayakawa Koji、Miyazawa Teruo、Sugihara Hitoshi、Oikawa Shinichi
- Journal Title
  
  Diabetologia
  
  Volume: accepted
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08780
[Journal Article] Hyperglycemia and Atherosclerosis: Experimental Results in Mice2017
- Author(s)
  浅井明
- Journal Title
  
  Nihon Ika Daigaku Igakkai Zasshi
  
  Volume: 13 Issue: 4 Pages: 194-198
- DOI
  10.1272/manms.13.194
- NAID
  130006896397
- ISSN
  1349-8975, 1880-2877
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-17K08780
[Journal Article] 脂肪摂取と2型糖尿病2015
- Author(s)
  長尾元嗣、浅井明、杉原仁、及川眞一
- Journal Title
  
  オレオサイエンス
  
  Volume: 15 Pages: 21-30
- NAID
  130006329110
- Data Source
  KAKENHI-PROJECT-26460497
[Journal Article] Repetitive Glucose Spikes Accelerate Atherosclerotic Lesion Formation in C57BL/6 Mice2015
- Author(s)
  Yuki Shuto, Akira Asai, Mototsugu Nagao, Hitoshi Sugihara, and Shinichi Oikawa
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 8 Pages: e0136840-e0136840
- DOI
  10.1371/journal.pone.0136840
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460497
[Journal Article] Fat intake and the development of type 2 diabetes [Review]2015
- Author(s)
  M Nagao, A Asai, H Sugihara, S Oikawa
- Journal Title
  
  Endocr J
  
  Volume: 62 Issue: 7 Pages: 561-572
- DOI
  10.1507/endocrj.EJ15-0055
- NAID
  130005089858
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08434, KAKENHI-PROJECT-26460497
[Journal Article] Transgenerational changes of metabolic phenotypes in two selectively bred mouse colonies for different susceptibilities to diet-induced glucose intolerance2015
- Author(s)
  Nagao M, Asai A, Sugihara H, Oikawa S
- Journal Title
  
  Endocr J
  
  Volume: 62 Issue: 4 Pages: 371-378
- DOI
  10.1507/endocrj.EJ14-0241
- NAID
  130005066937
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860300, KAKENHI-PROJECT-15K08434, KAKENHI-PROJECT-26460497
[Presentation] CD36 subcellular localisation in beta cells between diabetes-prone and -resistant mice: possible involvement of CD36 in beta cell dysfunction2022
- Author(s)
  Nagao Mototsugu、Asai Akira、Mikiko Okazaki-Hada、Hitoshi Sugihara、Eliasson Lena、Oikawa Shinichi
- Organizer
  58th Annual Meeting of the European Association for the Study of Diabetes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05453
[Presentation] CD36 subcellular localisation in beta cells between diabetes-prone and -resistant mice: possible involvement of CD36 in beta cell dysfunction2022
- Author(s)
  Mototsugu Nagao, Akira Asai, Mikiko Okazaki-Hada, Hitoshi Sugihara, Lena Eliasson, Shinichi Oikawa
- Organizer
  58th Annual Meeting of the European Association for the Study of Diabetes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07008
[Presentation] Oikawa-Nagao Diabetes-Prone マウスの体重増加・耐糖能悪化を規定するレプチン遺伝子の発現調節2022
- Author(s)
  羽田幹子、浅井明、長尾元嗣、及川眞一、岩部真人
- Organizer
  日本肥満学会(第43回) 日本肥満症治療学会(第40回) 学術集会
- Data Source
  KAKENHI-PROJECT-21K05453
[Presentation] Pathogenic role of beta-cell CD36 in the development of type 2 diabetes with obesity2021
- Author(s)
  長尾元嗣、浅井明、杉原仁、Claes B. Wollheim、及川眞一、 Lena Eliasson
- Organizer
  第64回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K05453
[Presentation] CD36によるβ細胞機能障害と糖尿病発症：Oikawa-Nagao(ON)マウスを端緒とした研究成果2020
- Author(s)
  長尾元嗣、浅井明、杉原仁、及川眞一
- Organizer
  第34回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K08780
[Presentation] CD36によるβ細胞機能障害と糖尿病発症：Oikawa-Nagao(ON)マウスを端緒とした研究成果2020
- Author(s)
  長尾元嗣、浅井明、杉原仁、及川眞一
- Organizer
  第34回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17KK0184
[Presentation] 新規耐糖能異常モデルマウスにおける過食・体重増加の規定因子：若齢期における低レプチンとその要因の探索2019
- Author(s)
  浅井明、長尾元嗣、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第33回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K08780
[Presentation] 選抜交配によって新たに確立した高脂肪食誘発性耐糖能異常モデルマウスにおける過食、体重増加とレプチンシグナルとの関係2018
- Author(s)
  浅井明、長尾元嗣、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第72回日本栄養・食糧学会大会
- Data Source
  KAKENHI-PROJECT-17K08780
[Presentation] CD36 is increased in human islets from obese T2D donors, and affects beta cell function by the modulation of exocytotic proteins and insulin content.2017
- Author(s)
  Nagao M, Esguerra JLS, Ofori JK, Wendt A, Asai A, Sugihra H, Oikawa S. Wollheim CB, Eliasson L.
- Organizer
  European Association for the Study of Diabetes 53rd Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08780
[Presentation] 膵島におけるCD36/FATの発現と脂肪酸動態、インスリン分泌能との関係：新規耐糖能異常モデルマウスを用いた解析2017
- Author(s)
  浅井明、長尾元嗣、都築毅、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K08780
[Presentation] 新規耐糖能異常モデルマウスにおける過食、体重増加：若齢期におけるレプチン動態との関係2017
- Author(s)
  浅井明、長尾元嗣、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホールヴィアマーレ（神奈川県横浜市）
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-26460497
[Presentation] Reduced insulin secretion in a diet-induced glucose intolerance susceptible mouse model is coupled with increased CD36 and triglycerides in the β cells.2017
- Author(s)
  Asai A, Nagao M, Tsuduki T, Miyazawa T, Esguerra JLS, Eliasson L, Sugihra H, Oikawa S.
- Organizer
  European Association for the Study of Diabetes 53rd Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08780
[Presentation] CD36 modulates exocytotic proteins and affects insulin secretion through miR-130a up-regulation in beta-cells2017
- Author(s)
  Nagao M, Esguerra JLS, Ofori JK, Asai A, Sugihra H, Oikawa S. Wollheim CB, Eliasson L.
- Organizer
  2nd Joint Meeting of the EASD Islet Study Group and Beta Cell Workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08780
[Presentation] Antiatherogenic effect of metformin in two mouse lines with different susceptibility to glucose intolerance2016
- Author(s)
  A Asai, M Nagao, M Kawahara, T Miyazawa, H Sugihara, S Oikawa
- Organizer
  84th European Atherosclerosis Society Congress
- Place of Presentation
  Congress und Messe Innsbruck GmbH, Innsbruck, Austria
- Year and Date
  2016-05-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460497
[Presentation] 選抜交配による高脂肪食誘発性糖尿病モデルマウスの開発2016
- Author(s)
  浅井明、長尾元嗣、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第70回日本栄養・食糧学会大会
- Place of Presentation
  武庫川女子大学（兵庫県西宮市）
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-26460497
[Presentation] 高脂肪食投与後の糖尿病発症における過食、体重増加とレプチンとの関係：新規選抜交配モデルマウスの解析から2016
- Author(s)
  浅井明、長尾元嗣、川原百代、加藤俊治、宮澤陽夫、杉原仁、及川眞一
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26460497
[Presentation] 選抜交配による新規耐糖能異常モデルマウスの作出とその解析2016
- Author(s)
  浅井明
- Organizer
  第28回夏期油脂・コレステロール研究会
- Place of Presentation
  ホテルパーク（岐阜県岐阜市）
- Year and Date
  2016-07-15
- Invited
- Data Source
  KAKENHI-PROJECT-26460497
[Presentation] 新規耐糖能異常モデルマウスにおけるメトホルミンの抗動脈硬化作用2015
- Author(s)
  周東佑樹、浅井明、長尾元嗣、杉原仁、及川眞一
- Organizer
  第23回日本過酸化脂質・抗酸化物質学会
- Place of Presentation
  東北大学片平キャンパス北門会館（宮城県仙台市）
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-26460497
[Presentation] Metforminの抗動脈硬化作用に関する耐糖能異常マウスを用いた検討2015
- Author(s)
  周東佑樹、浅井明、長尾元嗣、川原百代、杉原仁、及川眞一
- Organizer
  第47回日本動脈硬化学会・学術集会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-26460497
[Presentation] 食後高血糖が動脈硬化巣形成に及ぼす影響～新規耐糖能異常モデルマウスを用いた解析～2015
- Author(s)
  浅井明、周東佑樹、長尾元嗣、杉原仁、宮澤陽夫、及川眞一
- Organizer
  日本栄養・食糧学会東北支部（第49回）北海道支部（第45回）合同支部大会
- Place of Presentation
  東北大学農学部（宮城県仙台市）
- Year and Date
  2015-11-24
- Data Source
  KAKENHI-PROJECT-26460497
[Presentation] Twice-daily hyperglycaemic spikes accelerate atherosclerotic lesion formation in C57BL/6 mice
- Author(s)
  Y. Shuto, A. Asai, M. Nagao, M. Kalahari, H. Sugihara, S. Oikawa
- Organizer
  50th EASD Annual Meeting
- Place of Presentation
  Vienna, Austria
- Year and Date
  2014-09-15 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-26460497
[Presentation] 血糖変動が動脈硬化巣形成に及ぼす影響：マウスを用いた生体レベルでの解析
- Author(s)
  周東佑樹、浅井明、長尾元嗣、川原百代、杉原仁、及川眞一
- Organizer
  第46回日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-26460497

1. NAGAO Mototsugu (10468762)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
2. NAKAGAWA Kiyotaka (80361145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 杉原仁 (60183414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. 都築毅 (00404848)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

ASAI AKIRA 浅井 明

Asai Akira 浅井 明

ASAI Akira 浅井 明

Research Projects

Research Products

Co-Researchers

New pathophysiology of type 2 diabetes: Altered beta-cell CD36 expression and impaired insulin secretion

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Nutritional physiology of lipoadaptation/lipotoxicity in pancreatic beta cells in the development of type 2 diabetes mellitusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fatty acid dynamics as insulin secretion capacity regulating factor: analysis in human isletsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Fatty acid dynamics as insulin secretion capacity regulating factor: analysis in new model micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Impaired glucose tolerance as a risk factor for arteriosclerotic disease: analysis in new model micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Selectively bred rodent models for studying the etiology of type 2 diabetes: Goto-Kakizaki rats and Oikawa-Nagao mice2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Selectively Bred Diabetes Models: GK Rats, NSY Mice, and ON Mice2020

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Leptin production capacity determines food intake and susceptibility to obesity-induced diabetes in Oikawa-Nagao Diabetes-Prone and Diabetes-Resistant mice2020

Author(s)

Journal Title

Data Source

[Journal Article] Hyperglycemia and Atherosclerosis: Experimental Results in Mice2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] 脂肪摂取と2型糖尿病2015

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Repetitive Glucose Spikes Accelerate Atherosclerotic Lesion Formation in C57BL/6 Mice2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fat intake and the development of type 2 diabetes [Review]2015

Author(s)

Journal Title

DOI

ASAI AKIRA 浅井明

Asai Akira 浅井明

ASAI Akira 浅井明