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ASAI AKIRA  浅井 明

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浅井 明  アサイ アキラ

ASAI Akira  浅井 明

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Researcher Number 30500011
Other IDs
Affiliation (Current) 2022: 日本医科大学, 大学院医学研究科, 研究生
Affiliation (based on the past Project Information) *help 2021 – 2022: 日本医科大学, 大学院医学研究科, 研究生
2016 – 2019: 東北大学, 農学研究科, 特任准教授
2017: 東北大学, (連合)農学研究科(研究院), 准教授
2015: 東北大学, (連合)農学研究科(研究院), 准教授
2014: 日本医科大学, 医学部, 研究員
Review Section/Research Field
Principal Investigator
Experimental pathology / Basic Section 38050:Food sciences-related
Except Principal Investigator
Basic Section 49030:Experimental pathology-related
Keywords
Principal Investigator
糖尿病 / インスリン分泌 / モデルマウス / β細胞 / 脂肪毒性 / 膵島 / 脂肪酸 / 耐糖能異常 / 動脈硬化 / 血糖値変動 … More / ヒト膵島 / モデル動物 / ヒト / CD36 / 2型糖尿病 / 膵β細胞 … More
Except Principal Investigator
2型糖尿病 / インスリン分泌不全 / 膵β細胞 / CD36 / Oikawa-Nagaoマウス Less
  • Research Projects

    (5 results)
  • Research Products

    (26 results)
  • Co-Researchers

    (4 People)
  •  New pathophysiology of type 2 diabetes: Altered beta-cell CD36 expression and impaired insulin secretion

    • Principal Investigator
      長尾 元嗣
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Nippon Medical School
  •  2型糖尿病発症における膵β細胞の脂肪適応と脂肪毒性についての栄養生理学的検証Principal Investigator

    • Principal Investigator
      浅井 明
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 38050:Food sciences-related
    • Research Institution
      Nippon Medical School
  •  Fatty acid dynamics as insulin secretion capacity regulating factor: analysis in human isletsPrincipal Investigator

    • Principal Investigator
      Asai Akira
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research)
    • Research Field
      Experimental pathology
    • Research Institution
      Tohoku University
  •  Fatty acid dynamics as insulin secretion capacity regulating factor: analysis in new model micePrincipal Investigator

    • Principal Investigator
      Asai Akira
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Tohoku University
  •  Impaired glucose tolerance as a risk factor for arteriosclerotic disease: analysis in new model micePrincipal Investigator

    • Principal Investigator
      ASAI Akira
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Tohoku University
      Nippon Medical School

All 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

  • [Journal Article] Selectively Bred Diabetes Models: GK Rats, NSY Mice, and ON Mice2020

    • Author(s)
      Nagao Mototsugu、Esguerra Jonathan Lou S.、Wendt Anna、Asai Akira、Sugihara Hitoshi、Oikawa Shinichi、Eliasson Lena
    • Journal Title

      Methods Mol Biol.

      Volume: 2128 Pages: 25-54

    • DOI

      10.1007/978-1-0716-0385-7_3

    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08780, KAKENHI-PROJECT-17KK0184, KAKENHI-PROJECT-19K23872
  • [Journal Article] Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells2020

    • Author(s)
      Nagao Mototsugu、Esguerra Jonathan L.S.、Asai Akira、Ofori Jones K.、Edlund Anna、Wendt Anna、Sugihara Hitoshi、Wollheim Claes B.、Oikawa Shinichi、Eliasson Lena
    • Journal Title

      Diabetes

      Volume: in press Pages: 1193-1205

    • DOI

      10.2337/db19-0944

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08780, KAKENHI-PROJECT-17KK0184, KAKENHI-PROJECT-19K23872
  • [Journal Article] Leptin production capacity determines food intake and susceptibility to obesity-induced diabetes in Oikawa-Nagao Diabetes-Prone and Diabetes-Resistant mice2020

    • Author(s)
      Asai Akira、Nagao Mototsugu、Hayakawa Koji、Miyazawa Teruo、Sugihara Hitoshi、Oikawa Shinichi
    • Journal Title

      Diabetologia

      Volume: accepted

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08780
  • [Journal Article] Hyperglycemia and Atherosclerosis: Experimental Results in Mice2017

    • Author(s)
      浅井明
    • Journal Title

      Nihon Ika Daigaku Igakkai Zasshi

      Volume: 13 Issue: 4 Pages: 194-198

    • DOI

      10.1272/manms.13.194

    • NAID

      130006896397

    • ISSN
      1349-8975, 1880-2877
    • Language
      Japanese
    • Open Access
    • Data Source
      KAKENHI-PROJECT-17K08780
  • [Journal Article] Transgenerational changes of metabolic phenotypes in two selectively bred mouse colonies for different susceptibilities to diet-induced glucose intolerance2015

    • Author(s)
      Nagao M, Asai A, Sugihara H, Oikawa S
    • Journal Title

      Endocrine Journal

      Volume: 64 Issue: 4 Pages: 371-378

    • DOI

      10.1507/endocrj.ej14-0241

      10.1507/endocrj.EJ14-0241

    • NAID

      130005066937

    • ISSN
      0918-8959, 1348-4540
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25860300, KAKENHI-PROJECT-15K08434, KAKENHI-PROJECT-26460497
  • [Journal Article] Fat intake and the development of type 2 diabetes [Review]2015

    • Author(s)
      M Nagao, A Asai, H Sugihara, S Oikawa
    • Journal Title

      Endocrine Journal

      Volume: 62 Issue: 7 Pages: 561-572

    • DOI

      10.1507/endocrj.ej15-0055

      10.1507/endocrj.EJ15-0055

    • NAID

      130005089858

    • ISSN
      0918-8959, 1348-4540
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K08434, KAKENHI-PROJECT-26460497
  • [Journal Article] 脂肪摂取と2型糖尿病2015

    • Author(s)
      長尾元嗣、浅井明、杉原仁、及川眞一
    • Journal Title

      オレオサイエンス

      Volume: 15 Pages: 21-30

    • NAID

      130006329110

    • Data Source
      KAKENHI-PROJECT-26460497
  • [Journal Article] Repetitive Glucose Spikes Accelerate Atherosclerotic Lesion Formation in C57BL/6 Mice2015

    • Author(s)
      Yuki Shuto, Akira Asai, Mototsugu Nagao, Hitoshi Sugihara, and Shinichi Oikawa
    • Journal Title

      PLoS ONE

      Volume: 10

    • DOI

      10.1371/journal.pone.0136840

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460497
  • [Presentation] CD36によるβ細胞機能障害と糖尿病発症:Oikawa-Nagao(ON)マウスを端緒とした研究成果2020

    • Author(s)
      長尾元嗣、浅井明、杉原 仁、及川眞一
    • Organizer
      第34回日本糖尿病・肥満動物学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-17K08780
  • [Presentation] CD36によるβ細胞機能障害と糖尿病発症:Oikawa-Nagao(ON)マウスを端緒とした研究成果2020

    • Author(s)
      長尾元嗣、浅井明、杉原 仁、及川眞一
    • Organizer
      第34回日本糖尿病・肥満動物学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-17KK0184
  • [Presentation] 新規耐糖能異常モデルマウスにおける過食・体重増加の規定因子:若齢期における低レプチンとその要因の探索2019

    • Author(s)
      浅井明、長尾元嗣、宮澤陽夫、杉原仁、及川眞一
    • Organizer
      第33回日本糖尿病・肥満動物学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-17K08780
  • [Presentation] 選抜交配によって新たに確立した高脂肪食誘発性耐糖能異常モデルマウスにおける過食、体重増加とレプチンシグナルとの関係2018

    • Author(s)
      浅井明、長尾元嗣、宮澤陽夫、杉原仁、及川眞一
    • Organizer
      第72回日本栄養・食糧学会大会
    • Data Source
      KAKENHI-PROJECT-17K08780
  • [Presentation] CD36 is increased in human islets from obese T2D donors, and affects beta cell function by the modulation of exocytotic proteins and insulin content.2017

    • Author(s)
      Nagao M, Esguerra JLS, Ofori JK, Wendt A, Asai A, Sugihra H, Oikawa S. Wollheim CB, Eliasson L.
    • Organizer
      European Association for the Study of Diabetes 53rd Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08780
  • [Presentation] 膵島におけるCD36/FATの発現と脂肪酸動態、インスリン分泌能との関係:新規耐糖能異常モデルマウスを用いた解析2017

    • Author(s)
      浅井明、長尾元嗣、都築毅、宮澤陽夫、杉原仁、及川眞一
    • Organizer
      第60回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-17K08780
  • [Presentation] 新規耐糖能異常モデルマウスにおける過食、体重増加:若齢期におけるレプチン動態との関係2017

    • Author(s)
      浅井明、長尾元嗣、宮澤陽夫、杉原仁、及川眞一
    • Organizer
      第31回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      はまぎんホールヴィアマーレ(神奈川県横浜市)
    • Year and Date
      2017-02-10
    • Data Source
      KAKENHI-PROJECT-26460497
  • [Presentation] Reduced insulin secretion in a diet-induced glucose intolerance susceptible mouse model is coupled with increased CD36 and triglycerides in the β cells.2017

    • Author(s)
      Asai A, Nagao M, Tsuduki T, Miyazawa T, Esguerra JLS, Eliasson L, Sugihra H, Oikawa S.
    • Organizer
      European Association for the Study of Diabetes 53rd Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08780
  • [Presentation] CD36 modulates exocytotic proteins and affects insulin secretion through miR-130a up-regulation in beta-cells2017

    • Author(s)
      Nagao M, Esguerra JLS, Ofori JK, Asai A, Sugihra H, Oikawa S. Wollheim CB, Eliasson L.
    • Organizer
      2nd Joint Meeting of the EASD Islet Study Group and Beta Cell Workshop
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08780
  • [Presentation] Antiatherogenic effect of metformin in two mouse lines with different susceptibility to glucose intolerance2016

    • Author(s)
      A Asai, M Nagao, M Kawahara, T Miyazawa, H Sugihara, S Oikawa
    • Organizer
      84th European Atherosclerosis Society Congress
    • Place of Presentation
      Congress und Messe Innsbruck GmbH, Innsbruck, Austria
    • Year and Date
      2016-05-29
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460497
  • [Presentation] 選抜交配による高脂肪食誘発性糖尿病モデルマウスの開発2016

    • Author(s)
      浅井明、長尾元嗣、宮澤陽夫、杉原仁、及川眞一
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      武庫川女子大学(兵庫県西宮市)
    • Year and Date
      2016-05-13
    • Data Source
      KAKENHI-PROJECT-26460497
  • [Presentation] 高脂肪食投与後の糖尿病発症における過食、体重増加とレプチンとの関係:新規選抜交配モデルマウスの解析から2016

    • Author(s)
      浅井明、長尾元嗣、川原百代、加藤俊治、宮澤陽夫、杉原仁、及川眞一
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-26460497
  • [Presentation] 選抜交配による新規耐糖能異常モデルマウスの 作出とその解析2016

    • Author(s)
      浅井明
    • Organizer
      第28回夏期油脂・コレステロール研究会
    • Place of Presentation
      ホテルパーク(岐阜県岐阜市)
    • Year and Date
      2016-07-15
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460497
  • [Presentation] 新規耐糖能異常モデルマウスにおけるメトホルミンの抗動脈硬化作用2015

    • Author(s)
      周東佑樹、浅井明、長尾元嗣、杉原仁、及川眞一
    • Organizer
      第23回日本過酸化脂質・抗酸化物質学会
    • Place of Presentation
      東北大学片平キャンパス北門会館(宮城県仙台市)
    • Year and Date
      2015-08-22
    • Data Source
      KAKENHI-PROJECT-26460497
  • [Presentation] Metforminの抗動脈硬化作用に関する耐糖能異常マウスを用いた検討2015

    • Author(s)
      周東佑樹、浅井明、長尾元嗣、川原百代、杉原仁、及川眞一
    • Organizer
      第47回日本動脈硬化学会・学術集会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2015-07-09
    • Data Source
      KAKENHI-PROJECT-26460497
  • [Presentation] 食後高血糖が動脈硬化巣形成に及ぼす影響~新規耐糖能異常モデルマウスを用いた解析~2015

    • Author(s)
      浅井明、周東佑樹、長尾元嗣、杉原仁、宮澤陽夫、及川眞一
    • Organizer
      日本栄養・食糧学会東北支部(第49回)北海道支部(第45回) 合同支部大会
    • Place of Presentation
      東北大学農学部(宮城県仙台市)
    • Year and Date
      2015-11-24
    • Data Source
      KAKENHI-PROJECT-26460497
  • [Presentation] Twice-daily hyperglycaemic spikes accelerate atherosclerotic lesion formation in C57BL/6 mice

    • Author(s)
      Y. Shuto, A. Asai, M. Nagao, M. Kalahari, H. Sugihara, S. Oikawa
    • Organizer
      50th EASD Annual Meeting
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2014-09-15 – 2014-09-19
    • Data Source
      KAKENHI-PROJECT-26460497
  • [Presentation] 血糖変動が動脈硬化巣形成に及ぼす影響:マウスを用いた生体レベルでの解析

    • Author(s)
      周東佑樹、浅井明、長尾元嗣、川原百代、杉原仁、及川眞一
    • Organizer
      第46回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-10 – 2014-07-11
    • Data Source
      KAKENHI-PROJECT-26460497
  • 1.  NAGAO Mototsugu (10468762)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 15 results
  • 2.  NAKAGAWA Kiyotaka (80361145)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  杉原 仁 (60183414)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 4.  都築 毅 (00404848)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results

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