UMEZAWA Keitaro 梅澤啓太郎

… Alternative Names

Umezawa Keitaro 梅澤啓太郎

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Researcher Number	30505764
Other IDs
Affiliation (Current)	2026: 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 准主任研究員
Affiliation (based on the past Project Information) *help	2025 – 2026: 地方独立行政法人東京都健康長寿医療センター, 東京都健康長寿医療センター研究所, 准主任研究員 2023 – 2024: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 准主任研究員 2019 – 2023: 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Transformative Research Areas, Section (III)
Keywords	Principal Investigator 酸化ストレス / プロテオーム / プロテオミクス Except Principal Investigator 分子標的薬 / がん / プロテオミクス / レジリエンス / 治療寛容性 / チロシンキナーゼ阻害薬 / がんヘテロジェナイティ … More / ミトコンドリア / ヘテロジェナイティ / 治療抵抗性 / 細胞間コミュニケーション / 代謝リプログラミング / 蛍光プローブ / ポリスルフィド / 翻訳後修飾 / 超硫黄分子 Less

大規模超硫黄プロテオミクスが拓く加齢性疾患の病態解明と治療戦略Principal Investigator
- Principal Investigator
  
  梅澤啓太郎
- Project Period (FY)
  2026 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Tokyo Metropolitan Institute for Geriatrics and Gerontology
Targeting the resilience of cancer cell societies for next-generation therapeutics
- Principal Investigator
  
  青木重樹
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Chiba University
タンパク質の超硫黄修飾を基軸とした新しい疾患発症機構研究Principal Investigator
- Principal Investigator
  
  梅澤啓太郎
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo Metropolitan Institute for Geriatrics and Gerontology
Mechanism of constituting a cancer cell population resistant to molecular-targeted drugs
- Principal Investigator
  
  Aoki Shigeki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Chiba University
In-cell chemistry of supersulfur species in biology
- Principal Investigator
  
  中川秀彦
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Nagoya City University
Exploration of Mitochondrial Functional Regulators Using Chemical ToolsPrincipal Investigator
- Principal Investigator
  
  Umezawa Keitaro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology

All 2025 2024 2023 2022 2021 2019

All Journal Article Presentation Patent

[Journal Article] Polysulfur-based bulking of dynamin-related protein 1 prevents 1 ischemic sulfide catabolism and heart failure in mice.2025
- Author(s)
  Nishimura A, Ogata S, Tang X, Hengphasatporn K, Umezawa K, Sanbo M, Hirabayashi M, Kato Y, Ibuki Y, Kumagai Y, Kobayashi K, Urano Y, , Shigeta Y, Akaike T, Nishida M
- Journal Title
  
  Nature Communications
  
  Volume: 16:276 Issue: 1 Pages: 1-17
- DOI
  10.1038/s41467-024-55661-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05269, KAKENHI-PLANNED-23H04879, KAKENHI-PROJECT-23K24035, KAKENHI-PROJECT-22K19397, KAKENHI-PROJECT-23K24780, KAKENHI-PROJECT-23K28237, KAKENHI-PROJECT-24K02202, KAKENHI-PROJECT-24K02869, KAKENHI-PROJECT-23K14333, KAKENHI-PROJECT-24KJ1165, KAKENHI-PROJECT-23K20040
[Journal Article] Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells2024
- Author(s)
  Zhang Zhiheng、Aoki Haruna、Umezawa Keitaro、Kranrod Joshua、Miyazaki Natsumi、Oshima Taichi、Hirao Takuya、Miura Yuri、Seubert John、Ito Kousei、Aoki Shigeki
- Journal Title
  
  Cell Death Discovery
  
  Volume: 10 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41420-024-01933-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19368, KAKENHI-PROJECT-19KK0399
[Journal Article] Supersulfide catabolism participates in maladaptive remodeling of cardiac cells2024
- Author(s)
  Zhou L, Nishimura A, Umezawa K, Kato Y, Mi X, Ito T, Urano Y, Akaike T, Nishida M
- Journal Title
  
  Journal of Pharmacological Science
  
  Volume: 155:4 Issue: 4 Pages: 121-130
- DOI
  10.1016/j.jphs.2024.05.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05269, KAKENHI-PROJECT-23K24035, KAKENHI-PROJECT-22K19397, KAKENHI-PROJECT-23K24780, KAKENHI-PROJECT-24K02869, KAKENHI-PROJECT-23K20040
[Journal Article] Inorganic sulfides prevent osimertinib-induced mitochondrial dysfunction in human iPS cell-derived cardiomyocytes2024
- Author(s)
  Kondo M, Nakamura Y, Kato Y, Nishimura A, Fukata M, Moriyama S, Ito T, Umezawa K, Urano Y, Akaike T, Akashi K, Kanda Y, Nishida M
- Journal Title
  
  Journal of Pharmacological Science
  
  Volume: 156:2 Issue: 2 Pages: 69-76
- DOI
  10.1016/j.jphs.2024.07.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05269, KAKENHI-PROJECT-23K24035, KAKENHI-PROJECT-22K19397, KAKENHI-PROJECT-23K24780, KAKENHI-PROJECT-24K02202, KAKENHI-PROJECT-24K02869, KAKENHI-PROJECT-23K06164, KAKENHI-PROJECT-23K20040
[Patent] ポリスルフィド標識用アルキル化剤及びそれを用いたポリスルフィドの標識方法2022
- Inventor(s)
  梅澤啓太郎
- Industrial Property Rights Holder
  梅澤啓太郎
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-23K24780
[Patent] ポリスルフィド標識用アルキル化剤及びそれを用いたポリスルフィドの標識方法2021
- Inventor(s)
  梅澤啓太郎
- Industrial Property Rights Holder
  梅澤啓太郎
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-070477
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19K11685
[Presentation] 骨格筋におけるCARS1システインパースルフィド合成活性の生理学的役割2024
- Author(s)
  草野佑典, 村上昌平, 守田匡伸, 緒方星陵, 梅澤啓太郎, 曽我朋義, 香取幸夫, 赤池孝章, 本橋ほづみ
- Organizer
  第97回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K24780
[Presentation] ミトコンドリアtRNA硫黄修飾の分子基盤の解明2024
- Author(s)
  谷春菜, Raja Ahmad, Raja Norazireen, 張龍騰, 梅澤啓太郎, 西村明幸, 西田基宏, 足達俊吾, 荒磯裕平, 魏范研
- Organizer
  第97回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K24780
[Presentation] タンパク質の超硫黄修飾現象に着目した新しいプロテオーム研究2023
- Author(s)
  梅澤啓太郎, 津元裕樹, 川上恭司郎, 三浦ゆり
- Organizer
  TOBIRA第11回研究交流フォーラム
- Data Source
  KAKENHI-PROJECT-23K24780
[Presentation] ミトコンドリアtRNA硫黄修飾の分子基盤の解明2023
- Author(s)
  谷春菜, Raja Norazireen, Raja Ahmad, 張龍騰, 梅澤啓太郎, 西村明幸, 西田基宏, 足達俊吾, 魏范研
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K24780
[Presentation] Echinochromeによる硫黄代謝関連のマウス心筋梗塞後の慢性心不全改善2023
- Author(s)
  湯肖康, 西村明幸, 有吉航平, 西山和宏, 加藤百合, 諫田泰成, 梅澤啓太郎, 浦野泰照, 赤池孝章, 西田基宏
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K24780
[Presentation] Several LSD1 inhibitors have a potential to disturb fatty acid metabolism necessary for glycolysis-inhibited pancreatic cancers to survive2023
- Author(s)
  Zhiheng Zhang, Haruna Aoki, Keitaro Umezawa, Taichi Oshima, Takuya Hirao, Yuri Miura, Kousei Ito, Shigeki Aoki
- Organizer
  AACR ANNUAL MEETING 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19368
[Presentation] 新規タグ試薬を用いた超硫黄修飾タンパク質解析法の開発2022
- Author(s)
  梅澤啓太郎, 津元裕樹, 川上恭司郎, 三浦ゆり
- Organizer
  日本プロテオーム学会2022年大会（JHUPO第20回大会）
- Data Source
  KAKENHI-PROJECT-23K24780
[Presentation] 超硫黄修飾タンパク質の網羅的解析に資するタグ分子の開発2022
- Author(s)
  梅澤啓太郎, 津元裕樹, 川上恭司郎, 三浦ゆり
- Organizer
  第75回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24780
[Presentation] 超硫黄生物学を支える化学プローブの開発2021
- Author(s)
  梅澤啓太郎
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K11685
[Presentation] Development of a new chemical probe for specific detection of lysine-succinylated proteins2021
- Author(s)
  Keitaro Umezawa, Hiroki Tsumoto, Kyojiro Kawakami, Mako Kamiya, Yasuteru Urano, Tamao Endo, Yuri Miura
- Organizer
  Pacifichem2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11685
[Presentation] 化学タグ技術を用いたスクシニル化タンパク質の網羅的解析法の開発2021
- Author(s)
  梅澤啓太郎, 津元裕樹, 川上恭司郎, 神谷真子, 浦野泰照, 浦野泰照, 遠藤玉夫, 三浦ゆり
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K11685
[Presentation] 生体中の多硫化物質を検出可能な化学プローブ群の創製2019
- Author(s)
  梅澤啓太郎, 津元裕樹, 神谷真子, 浦野泰照, 三浦ゆり
- Organizer
  第8回TOBIRA研究交流フォーラム
- Data Source
  KAKENHI-PROJECT-19K11685

1. Aoki Shigeki (30728366)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 中川秀彦 (80281674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 異島優 (00457590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 水野忠快 (90736050)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 三浦ゆり (00216574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 西田基宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 赤池孝章

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

UMEZAWA Keitaro 梅澤 啓太郎

Umezawa Keitaro 梅澤 啓太郎

Research Projects

Research Products

Co-Researchers

大規模超硫黄プロテオミクスが拓く加齢性疾患の病態解明と治療戦略Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Targeting the resilience of cancer cell societies for next-generation therapeutics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

タンパク質の超硫黄修飾を基軸とした新しい疾患発症機構研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of constituting a cancer cell population resistant to molecular-targeted drugs

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

In-cell chemistry of supersulfur species in biology

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of Mitochondrial Functional Regulators Using Chemical ToolsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Polysulfur-based bulking of dynamin-related protein 1 prevents 1 ischemic sulfide catabolism and heart failure in mice.2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Supersulfide catabolism participates in maladaptive remodeling of cardiac cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inorganic sulfides prevent osimertinib-induced mitochondrial dysfunction in human iPS cell-derived cardiomyocytes2024

Author(s)

Journal Title

DOI

Data Source

[Patent] ポリスルフィド標識用アルキル化剤及びそれを用いたポリスルフィドの標識方法2022

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] ポリスルフィド標識用アルキル化剤及びそれを用いたポリスルフィドの標識方法2021

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] 骨格筋におけるCARS1システインパースルフィド合成活性の生理学的役割2024

Author(s)

Organizer

Data Source

[Presentation] ミトコンドリアtRNA硫黄修飾の分子基盤の解明2024

Author(s)

UMEZAWA Keitaro 梅澤啓太郎

Umezawa Keitaro 梅澤啓太郎