harada shigeyoshi 原田恵嘉

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HARADA Shigeyoshi 原田恵嘉

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Researcher Number	30508643
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所エイズ研究センター, 室長
Affiliation (based on the past Project Information) *help	2020 – 2024: 国立感染症研究所, エイズ研究センター, 室長 2016 – 2020: 国立感染症研究所, エイズ研究センター, 主任研究官 2014 – 2015: 国立感染症研究所, その他部局等, 主任研究官 2013: 東京大学, 医科学研究所, 特任研究員 2012: 国立感染症研究所, エイズ研究センター, 研究員 2010 – 2011: 熊本大学, エイズ学研究センター, COEリサーチ・アソシエイト
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Medical pharmacy
Keywords	Principal Investigator HIV / AIDS / 臨床分離株 / 耐性誘導 / 抗HIV療法 / 薬剤耐性 / SARS-CoV-2 / 抗体 / 抗HIV阻害剤 / 免疫学 … More / 感染症 / ウイルス / HIV-1 / オーダーメード医療 Less

抗体活性増強を基軸とするHIV治癒へ繋ぐADCC活性に関する基盤研究Principal Investigator
- Principal Investigator
  
  原田恵嘉
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  National Institute of Infectious Diseases
抗HIV薬研究を起点とする新規SARS-CoV-2治療戦略探索とウイルス性状解析Principal Investigator
- Principal Investigator
  
  原田恵嘉
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  National Institute of Infectious Diseases
Comprehensive study on HIV-specific ADCC responses using library clinical isolatesPrincipal Investigator
- Principal Investigator
  
  Shigeyoshi Harada
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  National Institute of Infectious Diseases
Countermeasure study on HIV Env diversity using library clinical isolatesPrincipal Investigator
- Principal Investigator
  
  Harada Shigeyoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  National Institute of Infectious Diseases
Establishment of in vitro selection system by multi anti-HIV drugsPrincipal Investigator
- Principal Investigator
  
  HARADA Shigeyoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  National Institute of Infectious Diseases
  The University of Tokyo
Establishment of in vitro selection system using recent primary isolates, and a new efficient treatment for HIVPrincipal Investigator
- Principal Investigator
  
  HARADA Shigeyoshi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kumamoto University

[Book] HIVエンベロープの治療標的構造研究：新規治療法における侵入阻害剤と中和抗体の関係2016
- Author(s)
  原田恵嘉，吉村和久
- Total Pages
  8
- Publisher
  日本エイズ学会誌
- Data Source
  KAKENHI-PROJECT-15K08125
[Journal Article] Late-Stage Derivatization of Oleanolic Acid-Based Anti-HIV-1 Compounds2024
- Author(s)
  Takeuchi Reon、Fujimoto Junko、Taguchi Yoshinori、Ide Ryuji、Kyan Ryuji、Sato Kohei、Mase Nobuyuki、Yokoyama Masaru、Harada Shigeyoshi、Narumi Tetsuo
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 3 Pages: 330-335
- DOI
  10.1248/cpb.c23-00891
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-03-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-22K05349
[Journal Article] Plasmacytoid dendritic cells stimulated with Lactococcus lactis strain Plasma produce soluble factors to suppress SARS-CoV-2 replication2023
- Author(s)
  Ishii Hiroshi、Jounai Kenta、Tsuji Ryohei、Ohshio Konomi、Kaneda Daiki、Okazaki Midori、Harada Shigeyoshi、Fujiwara Daisuke、Matano Tetsuro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 662 Pages: 26-30
- DOI
  10.1016/j.bbrc.2023.04.046
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-21H02745
[Journal Article] Hybrids of small CD4 mimics and gp41-related peptides as dual-target HIV entry inhibitors2022
- Author(s)
  Wang Rongyi、Tsuji Kohei、Kobayakawa Takuya、Liu Yishan、Yoshimura Kazuhisa、Matsushita Shuzo、Harada Shigeyoshi、Tamamura Hirokazu
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 76 Pages: 117083-117083
- DOI
  10.1016/j.bmc.2022.117083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-21H02970
[Journal Article] Development of a novel Macaque-Tropic HIV-1 adapted to cynomolgus macaques2022
- Author(s)
  Ode Hirotaka、Saito Akatsuki、Washizaki Ayaka、Seki Yohei、Yoshida Takeshi、Harada Shigeyoshi、Ishii Hiroshi、Shioda Tatsuo、Yasutomi Yasuhiro、Matano Tetsuro、Miura Tomoyuki、Akari Hirofumi、Iwatani Yasumasa
- Journal Title
  
  Journal of General Virology
  
  Volume: 103 Issue: 10 Pages: 001790-001790
- DOI
  10.1099/jgv.0.001790
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-23K24144
[Journal Article] Neutralizing-antibody-independent SARS-CoV-2 control correlated with intranasal-vaccine-induced CD8+ T?cell responses2022
- Author(s)
  Ishii H, Nomura T, Yamamoto H, Nishizawa M, Thu Hau TT, Harada S, Seki S, Nakamura-Hoshi M, Okazaki M, Daigen S, Kawana-Tachikawa A, Nagata N, Iwata-Yoshikawa N, Shiwa N, Suzuki T, Park ES, Ken M, Onodera T, Takahashi Y, Kusano K, Shimazaki R, Suzaki Y, Ami Y, Matano T
- Journal Title
  
  Cell Reports Medicine
  
  Volume: 3 Issue: 2 Pages: 100520-100520
- DOI
  10.1016/j.xcrm.2022.100520
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02745, KAKENHI-PROJECT-20K20498, KAKENHI-PROJECT-20K21666, KAKENHI-PROJECT-21K20767, KAKENHI-PROJECT-21K08501
[Journal Article] Association of envelope-specific B-cell differentiation and viral selective pressure signatures in HIV-1 CRF01_AE infection2022
- Author(s)
  Hau Trang Thi Thu、Nishizawa Masako、Harada Shigeyoshi、Phan My Ha、Kanno Yoshiaki、Nomura Takushi、Matsuoka Saori、Kawana-Tachikawa Ai、Hall William W.、Matano Tetsuro、Nguyen Lan Anh Thi、Yamamoto Hiroyuki
- Journal Title
  
  AIDS
  
  Volume: 36 Issue: 12 Pages: 1629-1641
- DOI
  10.1097/qad.0000000000003323
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-21H02745
[Journal Article] Exploratory studies on soluble small molecule CD4 mimics as HIV entry inhibitors2022
- Author(s)
  Tsuji Kohei、Kobayakawa Takuya、Konno Kiju、Masuda Ami、Takahashi Kohei、Ohashi Nami、Yoshimura Kazuhisa、Kuwata Takeo、Matsushita Shuzo、Harada Shigeyoshi、Tamamura Hirokazu
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 56 Pages: 116616-116616
- DOI
  10.1016/j.bmc.2022.116616
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-20H03362
[Journal Article] Design, synthesis, and bio-evaluation of novel triterpenoid derivatives as anti-HIV-1 compounds2022
- Author(s)
  Takeuchi Reon、Ogihara Kasumi、Fujimoto Junko、Sato Kohei、Mase Nobuyuki、Yoshimura Kazuhisa、Harada Shigeyoshi、Narumi Tetsuo
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 69 Pages: 128768-128768
- DOI
  10.1016/j.bmcl.2022.128768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-22K05349
[Journal Article] Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors2021
- Author(s)
  Kobayakawa Takuya、Tsuji Kohei、Konno Kiju、Himeno Ai、Masuda Ami、Yang Tingting、Takahashi Kohei、Ishida Yusuke、Ohashi Nami、Kuwata Takeo、Matsumoto Kaho、Yoshimura Kazuhisa、Sakawaki Hiromi、Miura Tomoyuki、Harada Shigeyoshi、Matsushita Shuzo、Tamamura Hirokazu
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 64 Issue: 3 Pages: 1481-1496
- DOI
  10.1021/acs.jmedchem.0c01153
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-18H02854, KAKENHI-PROJECT-18K06032, KAKENHI-PROJECT-18K08458, KAKENHI-PROJECT-19K22488, KAKENHI-PROJECT-19H03146, KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-21K08501
[Journal Article] Subacute SARS-CoV-2 replication can be controlled in the absence of CD8+?T cells in?cynomolgus?macaques2021
- Author(s)
  Nomura T, Yamamoto H, Nishizawa M, Hau TTT, Harada S, Ishii H, Seki S, Nakamura-Hoshi M, Okazaki M, Daigen S, Kawana-Tachikawa A, Nagata N, Iwata-Yoshikawa N, Shiwa N, Iida S, Katano H, Suzuki T, Park ES, Maeda K, Suzaki Y, Ami Y, Matano T
- Journal Title
  
  PLOS Pathogens
  
  Volume: 17 Issue: 7 Pages: 1-16
- DOI
  10.1371/journal.ppat.1009668
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02745, KAKENHI-PROJECT-21K08501, KAKENHI-PROJECT-20K20498, KAKENHI-PROJECT-20K21666
[Journal Article] Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s.2019
- Author(s)
  NAKATA H, MAEDA K, DAS D, CHANG SB, MATSUDA K, RAO KV, HARADA S, YOSHIMURA K, GHOSH AK, MITSUYA H.
- Journal Title
  
  Scientific Reports.
  
  Volume: 18 Issue: 5 Pages: 4828-4828
- DOI
  10.1016/j.bmcl.2019.01.011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08458
[Journal Article] Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s2019
- Author(s)
  Hirotomo Nakata, Kenji Maeda, Debananda Das, Simon B. Chang, Kouki Matsuda, Kalapala Venkateswara Rao, Shigeyoshi Harada, Kazuhisa Yoshimura, Arun K. Ghosh & Hiroaki Mitsuya
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 4828-4828
- DOI
  10.1038/s41598-019-41080-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08436, KAKENHI-PROJECT-18K08458
[Journal Article] Flexibility of small molecular CD4 mimics as HIV entry inhibitors.2018
- Author(s)
  KOBAYAKAWA T, OHASHI N, HIROTA Y, TAKAHASHI K, YAMADA Y, NARUMI T, YOSHIMURA K, MATSUSHITA S, HARADA S, TAMAMURA H
- Journal Title
  
  Bioorganic & Medical Chemistry
  
  Volume: 26 Issue: 21 Pages: 5664-5671
- DOI
  10.1016/j.bmc.2018.10.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08458, KAKENHI-PROJECT-18H02854
[Journal Article] Isolation and structure determination of a new lasso peptide specialicin based on genome mining.2018
- Author(s)
  KAWEEWAN I, HEMMI H, KOMAKI H, HARADA S, KODANI S.
- Journal Title
  
  Bioorganic & Medical Chemistry
  
  Volume: 26 Issue: 23-24 Pages: 6050-6055
- DOI
  10.1016/j.bmc.2018.11.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08458, KAKENHI-PROJECT-16K01913
[Journal Article] Driving HIV-1 into a Vulnerable Corner by Taking Advantage of Viral Adaptation and Evolution2017
- Author(s)
  Shigeyoshi Harada and Kazuhisa Yoshimura
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 8: 390 Pages: 390-390
- DOI
  10.3389/fmicb.2017.00390
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125
[Journal Article] A minimally cytotoxic CD4 mimic as an HIV entry inhibitor2016
- Author(s)
  Takaaki Mizuguchi, Shigeyoshi Harada, Tomoyuki Miura, Nami Ohashi, Tetsuo Narumi, Hiromi Mori, Yu Irahara, Yuko Yamada, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura, Hirokazu Tamamura
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 26 Issue: 2 Pages: 397-400
- DOI
  10.1016/j.bmcl.2015.11.103
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26105721, KAKENHI-PROJECT-15H04652, KAKENHI-PROJECT-15H04870, KAKENHI-PROJECT-26670053, KAKENHI-PUBLICLY-16H01420, KAKENHI-PROJECT-16H04682, KAKENHI-PROJECT-15K08125, KAKENHI-PROJECT-16K01931
[Journal Article] Biphasic CD8+ T-cell defense in elite SIV control by acute-phase passive neutralizing antibody immunization2016
- Author(s)
  Iseda S, Takahashi N, Poplimont H, Nomura T, Seki S, Nakane T, Nakamura M, Shi S, Ishii H, Furukawa S, Harada S, Naruse TK, Kimura A, Matano T, Yamamoto H
- Journal Title
  
  J Virol
  
  Volume: 90 Issue: 14 Pages: 6276-6290
- DOI
  10.1128/jvi.00557-16
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01271, KAKENHI-PROJECT-15H04737, KAKENHI-PROJECT-15K08125, KAKENHI-PROJECT-15K19119
[Journal Article] Small-Molecule CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors.2016
- Author(s)
  Nami Ohashi1, Shigeyoshi Harada, Takaaki Mizuguchi1, Yu Irahara1, Yuko Yamada, Misato Kotani, Wataru Nomura, Shuzo Matsushita, Kazuhisa Yoshimura, Hirokazu Tamamura.
- Journal Title
  
  Chem Med Chem
  
  Volume: 19 Issue: 8 Pages: 940-946
- DOI
  10.1002/cmdc.201500590
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125, KAKENHI-PROJECT-15H04652, KAKENHI-PROJECT-15H04870, KAKENHI-PROJECT-26670053, KAKENHI-PUBLICLY-16H01420, KAKENHI-PROJECT-16K01931, KAKENHI-PROJECT-16K15139
[Journal Article] Impact of the Maraviroc-Resistant Mutation M434I in the C4 Region of HIV-1 gp120 on Sensitivity to Antibody-Mediated Neutralization2016
- Author(s)
  Samatchaya Boonchawalit, Shigeyoshi Harada, Noriko Shirai, Hiroyuki Gatanaga, Shinichi Oka, Shuzo Matsushita, Kazuhisa Yoshimura.
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 69 Issue: 3 Pages: 236-243
- DOI
  10.7883/yoken.JJID.2015.310
- NAID
  130005151997
- ISSN
  1344-6304, 1884-2836
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125, KAKENHI-PROJECT-15H04870
[Journal Article] A novel dual luciferase assay for the simultaneous monitoring of HIV infection and cell viability2016
- Author(s)
  Mitsuki Y-y, Yamamoto T, Mizukoshi F, Momota M, Terahara K, Yoshimura K, Harada S, Tsunetsugu-Yokota Y
- Journal Title
  
  Journal of Virological Methods
  
  Volume: 231 Pages: 25-33
- DOI
  10.1016/j.jviromet.2016.02.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460500, KAKENHI-PROJECT-15K08125
[Journal Article] Fibrocytes differ from macrophages but can be infected with HIV-1.2015
- Author(s)
  M. Hashimoto, H. Nasser, F. Bhuyan, N. Kuse, Y. Satou, S. Harada, K. Yoshimura, J. Sakuragi, K. Monde, Y. Maeda, S. Welbourn, K. Strebel, E.W.A. El-Wahab, M. Miyazaki , S. Hattori, N. Chutiwitoonchai, M. Hiyoshi, S. Oka, M. Takiguchi, S. Suzu.
- Journal Title
  
  The Journal of Immunology
  
  Volume: 195 Issue: 9 Pages: 4341-4350
- DOI
  10.4049/jimmunol.1500955
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125, KAKENHI-PROJECT-26461407, KAKENHI-PROJECT-26461428, KAKENHI-PROJECT-15J07744, KAKENHI-PROJECT-25460567, KAKENHI-PROJECT-26670226
[Journal Article] Impact of maraviroc-resistant and low-CCR5- adapted mutations induced by in vitro passage on sensitivity to anti-envelope neutralizing antibodies.2014
- Author(s)
  Kazuhisa Yoshimura, Shigeyoshi Harada, Samatchaya Boonchawalit, Yoko Kawanami, Shuzo Matsushita.
- Journal Title
  
  Journal of General Virology
  
  Volume: 95 Issue: 8 Pages: 1816-1826
- DOI
  10.1099/vir.0.062885-0
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590199, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485
[Journal Article] Impact of antiretroviral pressure on selection of primary human immunodeficiency virus type 1 envelope sequences in vitro.2013
- Author(s)
  Shigeyoshi Harada, Kazuhisa Yoshimura, Aki Yamaguchi, Samatchaya Boonchawalit, Keisuke Yusa, Shuzo Matsushita.
- Journal Title
  
  Journal of General Virology
  
  Volume: 94 Issue: 5 Pages: 933-943
- DOI
  10.1099/vir.0.047167-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590199, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485
[Journal Article] A CD4 Mimic as an HIV Entry Inhibitors: Pharmacokinetics2013
- Author(s)
  Hashimoto, C., Narumi, T., Otsuki, H., Hirota, Y., Arai, H., Yoshimura, K., Harada, S., Ohashi, N., Nomura, W., Miura, T., Igarashi, T., Matsuhita, S., Tamamura, H.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 21 Issue: 24 Pages: 7884-7889
- DOI
  10.1016/j.bmc.2013.10.005
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24105507, KAKENHI-PUBLICLY-24119506, KAKENHI-PROJECT-24590199, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PROJECT-24659043, KAKENHI-PROJECT-24790107, KAKENHI-PROJECT-25410171
[Journal Article] CD4 Mimics as HIV Entry Inhibitors: Lead Optimization Studies of the Aromatic Substituents.2013
- Author(s)
  Narumi, T., Arai, H., Yoshimura, K., Harada, S., Hirota, Y., Ohashi, N., Hashimoto, C.. Nomura, W., Matsushita, S. and Tamamura, H.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 8 Issue: 9 Pages: 2518-2526
- DOI
  10.1016/j.bmc.2013.02.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05127, KAKENHI-PUBLICLY-24105507, KAKENHI-PROJECT-24590199, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PROJECT-24659043, KAKENHI-PROJECT-24790107
[Journal Article] Small molecular CD4 mimics as HIV entry inhibitors2011
- Author(s)
  Narumi, T., Arai, H., Yoshimura, K., Harada, S., Nomura, W., Matsushita, S., Tamamura. H
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 19 Pages: 6735-6742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790163
[Journal Article] In vitro and In vivo Resistance to Human Immunodeficiency Virus Type 1 Entry Inhibitors2011
- Author(s)
  Maeda, Y., Yoshimura, K., Miyamoto, F., Kodama, E., Harada, S., Yuan, Y., Harada, S., and Yusa, K
- Journal Title
  
  J AIDS Clinic Res
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790163
[Journal Article] Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds2010
- Author(s)
  Yoshimura, K., Harada, S., Shibata, J., Hatada, M., Yamada, Y., Ochiai, C., Tamamura, H., Matsushita S
- Journal Title
  
  J. Virol
  
  Volume: 84 Pages: 7558-7568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790163
[Journal Article] CD4 mimics targeting the mechanism of HIV entry2010
- Author(s)
  Yamada, Y., Ochiai, C., Yoshimura, K., Tanaka, T., Ohashi, N., Narumi, T., Nomura, W., Harada, S., Matsushita, S., Tamamura. H
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 20 Pages: 354-358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790163
[Journal Article] CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist2010
- Author(s)
  Narumi, T., Ochiai, C., Yoshimura, K., Harada, S., Tanaka, T., Nomura, W., Arai, H., Ozaki, T., Ohashi, N., Matsushita, S., Tamamura, H
- Journal Title
  
  Bioorg Med Chem Lett
  
  Pages: 5853-5858
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790163
[Journal Article] HIV-1 evasion of a neutralizing anti-V3 antibody involves acquisition of a potential glycosylation site in V22010
- Author(s)
  Hatada, M., Yoshimura, K., Harada, S., Kawanami, Y., Shibata, J., Matsushita S
- Journal Title
  
  J. Gen. Virol
  
  Volume: 91 Pages: 1335-1345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790163
[Patent] 抗HIV活性を有するCD4ミミック化合物2019
- Inventor(s)
  松下修三, 吉村和久, 玉村啓和, 原田恵嘉, 他4名
- Industrial Property Rights Holder
  松下修三, 吉村和久, 玉村啓和, 原田恵嘉, 他4名
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-195967
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18K08458
[Patent] オレアノール酸誘導体2018
- Inventor(s)
  鳴海哲夫, 原田恵嘉, 他4名
- Industrial Property Rights Holder
  鳴海哲夫, 原田恵嘉, 他4名
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-18K08458
[Patent] HIV感染阻害剤2015
- Inventor(s)
  玉村啓和、野村渉、鳴海哲夫、松下修三、吉村和久、原田恵嘉、他
- Industrial Property Rights Holder
  玉村啓和、野村渉、鳴海哲夫、松下修三、吉村和久、原田恵嘉、他
- Industrial Property Rights Type
  特許
- Filing Date
  2015-05-25
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] HIV侵入阻害剤の開発2020
- Author(s)
  原田恵嘉
- Organizer
  第34回日本エイズ学会学術集会・総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08458
[Presentation] Triterpene derivative NAT-078 as a novel bifunctional HIV-1 entry inhibitor2019
- Author(s)
  Shigeyoshi Harada, Tetsuo Narumi, Yuta Hikichi, Tetsuro Matano, Kazuhisa Yoshimura
- Organizer
  10th IAS Conference on HIV Science (IAS 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08458
[Presentation] 新規トリテルペン誘導体の抗HIV作用および耐性機序に対する詳細解析2019
- Author(s)
  原田恵嘉、引地優太、俣野哲朗、吉村和久
- Organizer
  第29回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K08458
[Presentation] Efficacy of a novel triterpene derivative in combination with neutralizing antibodies against HIV-1 infection2019
- Author(s)
  Shigeyoshi Harada, Tetsuo Narumi, Tetsuro Matano, Kazuhisa Yoshimura
- Organizer
  2019 Cold Spring Harbor meeting: Retroviruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08458
[Presentation] 網羅的Env標的阻害剤ライブラリーの構築-32018
- Author(s)
  原田恵嘉, 野村渉, 鳴海哲夫, 横山勝, 前田賢次, 竹内怜音, 紺野奇重, 引地優太, 佐藤裕徳, 玉村啓和, 俣野哲朗, 吉村和久
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K08458
[Presentation] Mutations in the gp41 ectodomain can contribute to HIV-1 resistance to smFIs2018
- Author(s)
  HARADA S, HIKICHI Y, NARUMI T, YOSHIMURA K
- Organizer
  26th Conference on Retroviruses and Opportunistic Infections (CROI 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08458
[Presentation] Triterpene derivative NAT-078 as a novel bifunctional HIV-1 entry inhibitor2018
- Author(s)
  HARADA S, NARUMI T, HIKICHI Y, MATANO T, YOSHIMURA K
- Organizer
  第66回日本ウイルス学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08458
[Presentation] Synergistic anti-HIV effect of combination of a novel entry inhibitor and NAbs2018
- Author(s)
  HARADA S, MATANO T, YOSHIMURA K
- Organizer
  20th International Conference on Emerging Infectious Diseases in the Pacific Rim and Meetings of the AIDS (Joint with Immunology Board)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] Identification of novel HIV-1 Env inhibitors by structure-based in silico screening2017
- Author(s)
  HARADA S, YOKOYAMA M, OGIHARA K, HIKICHI Y, SATO H, NARUMI T, MATANO T, YOSHIMURA K
- Organizer
  18th Kumamoto AIDS Seminar, Kumamoto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] Bifunctional抗HIV侵入阻害剤ライブラリーの構築およびその最新知見2017
- Author(s)
  原田恵嘉, 引地優太, 俣野哲朗, 吉村和久
- Organizer
  第19回白馬シンポジウム
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] Synthesis and properties of novel soluble bifunctional CD4-mimetic small molecules containing pyridine moiety2017
- Author(s)
  HARADA S, KONNO K, HIKICHI Y, MATSUOKA S, M ATANO T, TAMAMURA H, YOSHIMURA K
- Organizer
  9th IAS Conference on HIV Science (IAS 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] 網羅的Env標的阻害剤ライブラリーの構築-22017
- Author(s)
  原田恵嘉, 野村渉, 鳴海哲夫, 横山勝, 前田賢次, 林宏典, 紺野奇重, 引地優太, 佐藤裕徳, 玉村啓和, 俣野哲朗, 吉村和久
- Organizer
  第31回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] Discovery of novel bifunctional HIV-1 entry inhibitors using structure-based in silico screening2017
- Author(s)
  HARADA S, YOKOYAMA M, OGIHARA K, HIKICHI Y, SATO H, NARUMI T, MATANO T, YOSHIMURA K
- Organizer
  The 65th Annual Meeting of the Japanese Society for Virology
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] Bi-functional entry inhibitors sensitize macaque-tropic human immunodeficiency virus type 1 (HIV-1mt) to antibodies generated in HIV-1mt-infected macaques2017
- Author(s)
  HARADA S, HIKICHI Y, SEKI Y, SAITO A, YOSHIDA T, ODE H, IWATANI Y, YASUTOMI Y, MIURA T, MATANO T, AKARI H, YOSHIMURA K
- Organizer
  35th Annual Symposium on Nonhuman Primate Models for AIDS (NHP2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] Identification of novel HIV-1 gp120 CD4 binding site inhibitors using structure-based in silico screening2017
- Author(s)
  HARADA S, YOKOYAMA M, OGIHARA K, HIKICHI Y, SATO H, NARUMI T, MATANO T, YOSHIMURA K
- Organizer
  42nd Annual Meeting of Cold Spring Harbor Laboratory on Retroviruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] Structure-based virtual screeningによる新規bifunctional抗HIV侵入阻害剤の探索2017
- Author(s)
  原田恵嘉, 荻原香澄, 横山勝, 引地優太, 佐藤裕徳, 俣野哲朗, 鳴海哲夫, 吉村和久
- Organizer
  第27回抗ウイルス療法学会総会,
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] 作用部位の異なるEnv標的阻害剤ライブラリーの構築およびその最新知見2016
- Author(s)
  原田恵嘉, 引地優太, 俣野哲朗, 吉村和久
- Organizer
  第18回白馬シンポジウム
- Place of Presentation
  山梨県北杜市
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] Molecular Dynamics of the CD4-Mimetic Resistant HIV-1 Gp120 by MD Simulation2016
- Author(s)
  Shigeyoshi Harada, Masaru Yokoyama, Shuzo Matsushita, Hironori Sato, Tetsuro Matano, Kazuhisa Yoshimura
- Organizer
  23th Conference on Retroviruses and Opportunistic Infections (CROI 2016)
- Place of Presentation
  Boston, MA, U.S.A.
- Year and Date
  2016-02-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] 6.Detection of potency and breadth of anti-HIV-1 neutralizing antibodies in two macaque-tropic HIV-1 infected cynomolgus monkeys that were different response by CD8 depletion2016
- Author(s)
  Shigeyoshi Harada, Akatsuki Saito, Yohei Seki, Yasuhiro Yasutomi, Tomoyuki Miura, Tetsuro Matano, Hirofumi Akari, Kazuhisa Yoshimura
- Organizer
  2nd Kumamoto IRCMS International Symposium and 17th Kumamoto AIDS Seminar, Kumamoto
- Place of Presentation
  Kumamoto
- Year and Date
  2016-10-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] Development of novel bifunctional entry inhibitors that target non-CD4-binding site of HIV-12016
- Author(s)
  Shigeyoshi Harada, Kasumi Ogihara, Yuta Hikichi, Tetsuro Matano, Tetsuo Narumi, Kazuhisa Yoshimura
- Organizer
  The 64th Annual Meeting of the Japanese Society for Virology
- Place of Presentation
  Sapporo
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] Comparison of plasma neutralizing antibodies in two macaque-tropic HIV-1 infected macaques that were different response by CD8 depletion2016
- Author(s)
  Shigeyoshi Harada, Yohei Seki, Yasuhiro Yasutomi, Tomoyuki Miura, Tetsuro Matano, Hirofumi Akari, Kazuhisa Yoshimura
- Organizer
  34th Annual Symposium on Nonhuman Primate Models for AIDS (NHP2016),
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-10-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] Design, Synthesis, and Antiviral Activity of Novel Bifunctional CD4-Mimetic Small Molecules Containing Mono-Cyclohexyl Moieties, YIR-819 and YIR-8212016
- Author(s)
  Shigeyoshi Harada, Yu Irahara, Yuta Hikichi, Nami Ohashi, Wataru Nomura, Shuzo Matsushita, Tetsuro Matano, Hirokazu Tamamura, Kazuhisa Yoshimura
- Organizer
  HIVR4P 2016
- Place of Presentation
  Chicago, USA
- Year and Date
  2016-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] CD4 mimicと結合領域が異なる新規bifunctional抗HIV侵入阻害剤の開発2016
- Author(s)
  原田恵嘉, 荻原香澄, 俣野哲朗, 鳴海哲夫, 吉村和久
- Organizer
  第26回抗ウイルス療法学会総会
- Place of Presentation
  名古屋市
- Year and Date
  2016-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] 網羅的Env標的阻害剤ライブラリーの構築-12016
- Author(s)
  原田恵嘉, 野村渉, 鳴海哲夫, 横山勝, 前田賢次, 林宏典, 荻原香澄, 石田有佑, 引地優太, 佐藤裕徳, 玉村啓和, 俣野哲朗, 吉村和久
- Organizer
  第30回日本エイズ学会学術集会・総会
- Place of Presentation
  鹿児島市
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] Genetic and molecular dynamics studies of the NBD-556, YYA-021 and JRC-II-191 binding to the wild type and mutant HIV-1 gp1202015
- Author(s)
  Shigeyoshi Harada, Masaru Yokoyama, Shuzo Matsushita, Hironori Sato, Kazuhisa Yoshimura
- Organizer
  The 15th Kumamoto AIDS Seminar
- Place of Presentation
  熊本県阿蘇市
- Year and Date
  2015-10-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] gp120相互作用強化型CD4ミミック化合物の開発2015
- Author(s)
  原田恵嘉
- Organizer
  第18回日本レトロウイルス研究会夏期セミナー
- Place of Presentation
  名古屋
- Year and Date
  2015-07-10
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] Asp368およびVal430と相互作用を有する新規CD4類似低分子化合物の開発2015
- Author(s)
  原田恵嘉、苛原優、玉村啓和、俣野哲朗、吉村和久
- Organizer
  第25回抗ウイルス療法学会総会
- Place of Presentation
  東京
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] Detection of potency and breadth of HIV-1 neutralizing antibodies in macaque-tropic HIV-1 infected cynomolgus monkeys using novel test panel viruses2015
- Author(s)
  Shigeyoshi Harada, Akatsuki Saito, Takeshi Yoshida, Yohei Seki, Yuji Watanabe, Yasumasa Iwatani, Yasuhiro Yasutomi, Tomoyuki Miura, Tetsuro Matano, Hirofumi Akari, Kazuhisa Yoshimura
- Organizer
  33rd Annual Symposium on Nonhuman Primate Models for AIDS
- Place of Presentation
  Monterey, CA, U.S.A.
- Year and Date
  2015-10-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] Design, synthesis and virological evaluation of novel CD4-mimetic small molecules2015
- Author(s)
  Shigeyoshi Harada, Yu Irahara, Hirokazu Tamamura, Shuzo Matsushita, Tetsuro Matano, Kazuhisa Yoshimura
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡市
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] CD4類似低分子化合物誘導体（CD4MCs）の耐性機序解析2015
- Author(s)
  原田恵嘉、横山勝、佐藤裕徳、松下修三、俣野哲朗、玉村啓和、吉村和久
- Organizer
  第29回日本エイズ学会学術集会・総会
- Place of Presentation
  東京
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] Asp368およびVal430と相互作用を有する新規CD4類似低分子化合物の開発2015
- Author(s)
  原田恵嘉、苛原優、玉村啓和、俣野哲朗、吉村和久
- Organizer
  第17回白馬シンポジウム
- Place of Presentation
  鳥取県米子市
- Year and Date
  2015-06-19
- Data Source
  KAKENHI-PROJECT-15K08125
[Presentation] Impact of CD4 mimetics-resistant mutations on susceptibilities to anti-Env nMAbs.2014
- Author(s)
  Shigeyoshi Harada, Samatchaya Boonchawalit, Tetsuo Narumi, Hirokazu Tamamura, Shuzo Matsushita, Kazuhisa Yoshimura.
- Organizer
  21th Conference on Retroviruses and Opportunistic Infections (CROI 2014)
- Place of Presentation
  Boston, MA, U.S.A.
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] Impact od deletion in cytoplasmic tail on Env incorporation into HIV/SIV particles.2013
- Author(s)
  五領舞衣, 原田恵嘉, 石井洋,俣野哲朗, 吉村和久.
- Organizer
  第15回白馬シンポジウム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] 細胞内ドメイン欠損Envを有するHV/SIV粒子の作製.2013
- Author(s)
  五領舞衣, 原田恵嘉, 石井洋, 吉村和久, 俣野哲朗.
- Organizer
  第27回日本エイズ学会学術集会・総会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] Characterization of highly neutralizing antibody sensitive HIV-1 gp120 induced under high concentrations of maraviroc (MVC) in vitro. AIDS Vaccine 20132013
- Author(s)
  Samatchaya Boonchawalit, Shigeyoshi Harada, Shuzo Matsushita, Kazuhisa Yoshimura.
- Organizer
  AIDS Vaccine 2013
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] バルクおよびクローンウイルスを用いたCD4類似低分子化合物誘導体に対するin vitro 耐性ウイルス誘導.2013
- Author(s)
  原田恵嘉, 鳴海哲夫, Samatchaya Boonchawalit, 玉村啓和, 松下修三, 吉村和久.
- Organizer
  第27回日本エイズ学会学術集会・総会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] バルクおよびクローンウイルスを用いたCD4類似低分子化合物の耐性誘導.2013
- Author(s)
  原田恵嘉.
- Organizer
  第16回日本レトロウイルス研究会夏期セミナー
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] Analysis of relationships between Maraviroc (MVC) resistant mutations and sensitivity to antibody-mediated neutralization.2013
- Author(s)
  Samatchaya Boonchawalit, 原田恵嘉, 松下修三, 吉村和久.
- Organizer
  第27回日本エイズ学会学術集会・総会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] Analysis of relationships between Maraviroc (MVC) resistant mutations and sensitivity to antibody-mediated neutralization.2013
- Author(s)
  Samatchaya Boonchawalit, Shigeyoshi Harada, Shuzo Matsushita, Kazuhisa Yoshimura.
- Organizer
  14th Kumamoto AIDS Seminar, Kumamoto
- Place of Presentation
  Kumamoto, Japan
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] 抗V3抗体および低分子CD4ミミック曝露後投与によるアカゲザルでのSHIV複製抑制.2013
- Author(s)
  大附寛幸,丸田泰広,橋本智恵,鳴海哲夫,廣田雄樹, 原田恵嘉, 三浦智行, 吉村和久,玉村啓和,松下修三, 五十嵐樹彦.
- Organizer
  第27回日本エイズ学会学術集会・総会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] インテグラーゼ阻害剤ラルテグラビルがMVC耐性HIV-1 Env領域に与える影響.2013
- Author(s)
  原田恵嘉, Samatchaya Boonchawalit, 松下修三, 吉村和久.
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] CD4 Mimic Small Compounds, NBD-556 and Its Analogues Bind at 3 Amino Acid Positions in the gp120 CD4 Cavity2013
- Author(s)
  Shigeyoshi Harada, Samatchaya Boonchawalit, Tetsuo Narumi, Hirokazu Tamamura, Shuzo Matsushita, and Kazuhisa Yoshimura
- Organizer
  20th Conference on Retroviruses and Opportunistic Infections (CROI)
- Place of Presentation
  Atlanta, GA, USA
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] Impact of Maraviroc-resistant and Low CCR5-adapted Mutations Induced in vitro Passage on Sensitivity to Anti-Env Neutralizing Antibodies2013
- Author(s)
  Kazuhisa Yoshimura, Shigeyoshi Harada, Samatchaya Boonchawalit, and Shuzo Matsushita
- Organizer
  20th Conference on Retroviruses and Opportunistic Infections (CROI)
- Place of Presentation
  Atlanta, GA, USA
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] In vitro selection of bifunctional CD4 mimic small compounds (NBD analogues) using bulk and cloned primary isolates.2013
- Author(s)
  原田恵嘉, Samatchaya Boonchawalit, 松下修三, 吉村和久.
- Organizer
  第15回白馬シンポジウム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] In vitro selection of bifunctional CD4 mimic small compounds (NBD analogues) using bulk and cloned primary isolates.2013
- Author(s)
  Shigeyoshi Harada, Samatchaya Boonchawalit, Tetsuo Narumi, Hirokazu Tamamura, Shuzo Matsushita, Kazuhisa Yoshimura.
- Organizer
  14th Kumamoto AIDS Seminar, Kumamoto
- Place of Presentation
  Kumamoto, Japan
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] Analysis of interaction between gp120 and CD4 mimic small compounds that enhance the activity of anti-HIV neutralizing antibodies.2013
- Author(s)
  Shigeyoshi Harada, Samatchaya Boonchawalit, Shuzo Matsushita, Kazuhisa Yoshimura.
- Organizer
  AIDS Vaccine 2013
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] R5臨床分離株を用いた10種のCD4類似低分子化合物に対するin vitro 耐性ウイルス誘導2012
- Author(s)
  原田恵嘉
- Organizer
  第14回白馬シンポジウム
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] CD4類似低分子化合物の耐性機序および結合部位の検討.2012
- Author(s)
  原田恵嘉
- Organizer
  第15回 SUMMER RETROVIRUS CONFERENCE
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] In vitro induction of ten CD4 mimic small compounds, NBD-556 and its analogues, resistant variants using primary R5 HIV-1.2012
- Author(s)
  Shigeyoshi Harada, Hiroshi Arai, Tetsuo Narumi, Hirokazu Tamamura, Shuzo Matsushita, and Kazuhisa Yoshimura
- Organizer
  19th International AIDS Conference.
- Place of Presentation
  Washington, D.C., U.S.A.
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] HIV-1におけるCD4類似低分子化合物に対する耐性機序および結合部位の検討2012
- Author(s)
  原田恵嘉
- Organizer
  第9回ウイルス学キャンプ in 湯河原
- Place of Presentation
  静岡県熱海市
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] R5臨床分離株を用いたCD4類似低分子化合物誘導体に対するin vitro 耐性ウイルス誘導2012
- Author(s)
  原田恵嘉、鳴海哲夫、玉村啓和、松下修三、吉村和久
- Organizer
  第26回日本エイズ学会学術集会・総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] Impact of raltegravir pressure on the selection of HIV-1 envelope sequences in vitro2011
- Author(s)
  Harada, S.
- Organizer
  6th IAS Conference on HIV Pathogenesis, Treatment and Prevention
- Place of Presentation
  Auditorium Parco della Musica (Roma, Italy)
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-22790163
[Presentation] Impact of raltegravir pressure on the selection of HIV-1 envelope sequences in vitro2011
- Author(s)
  Harada, S.
- Organizer
  12th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Aso Resort GRANDVRIO Hotel (Kumaraoto, Japan)
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-22790163
[Presentation] Evolution and selection of the env gene of HIV-1 primary isolates during in vitro selection of raltegravir2011
- Author(s)
  Harada S., Hamji A., Matsushita S., Yoshimura K
- Organizer
  11th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Aso Resort GRANDVRIO Hotel(Kumamoto, Japan)
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-22790163
[Presentation] 抗HIV剤がEnv多様性に与える影響2011
- Author(s)
  原田恵嘉
- Organizer
  第25回日本エイズ学会学術集会・総会
- Place of Presentation
  ハイアットリージェンシー東京(東京都)
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-22790163
[Presentation] 抗HIV剤がEnv多様性に与える影響2011
- Author(s)
  原田恵嘉、濱治有希、遊佐敬介、松下修三、吉村和久
- Organizer
  第25回日本エイズ学会学術集会・総会
- Place of Presentation
  ハイアットリージェンシー東京(東京)
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-22790163
[Presentation] Impact of raltegravir pressure on the selection of HIV-1 envelope sequences in vitro2011
- Author(s)
  Harada S., Ishikawa T., Hamji A., Matsushita S., Yoshimura K
- Organizer
  6th IAS Conference on HIV Pathogenesis, Treatment and Prevention
- Place of Presentation
  Auditorium Parco della Musica(Roma, Italy)
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-22790163
[Presentation] Impact of raltegravir pressure on the selection of HIV-1 envelope sequences in vitro2011
- Author(s)
  Harada S., Ishikawa T., Hamji A., Matsushita S., Yoshimura K
- Organizer
  12th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  Aso Resort GRANDVRIO Hotel(Kumamoto, Japan)
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-22790163
[Presentation] ラルテグラビルはHIV-1のin vitro馴化におけるEnv選択に影響する2010
- Author(s)
  原田恵嘉
- Organizer
  第24回日本エイズ学会学術集会・総会
- Place of Presentation
  (東京)グランドプリンスホテル高輪
- Year and Date
  2010-11-25
- Data Source
  KAKENHI-PROJECT-22790163
[Presentation] ラルテグラビルはHIV-1のin vitro馴化におけるEnv選択に影響する2010
- Author(s)
  原田恵嘉、濱治有希、松下修三、吉村和久
- Organizer
  第24回日本エイズ学会学術集会・総会
- Place of Presentation
  ザ・プリンスさくらタワー東京(東京)
- Year and Date
  2010-11-25
- Data Source
  KAKENHI-PROJECT-22790163
[Presentation] 新規エントリー阻害剤の組み合わせによる抗ウイルス効果と耐性変異の解析.
- Author(s)
  原田恵嘉, 横山勝, Samatchaya Boonchawalit, 佐藤裕徳, 松下修三, 吉村和久.
- Organizer
  第16回白馬シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2014-06-13 – 2014-06-14
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] Mutations at the bottom of the Phe43 cavity are responsible for cross-resistance to NBD analogues.
- Author(s)
  Shigeyoshi Harada, Yu Irahara, Samatchaya Boonchawalit, Mai Goryo, Hirokazu Tamamura, Tetsuro Matano, Shuzo Matsushita, Kazuhisa Yoshimura.
- Organizer
  22th Conference on Retroviruses and Opportunistic Infections (CROI 2015)
- Place of Presentation
  Seattle, WA, U.S.A.
- Year and Date
  2015-02-23 – 2015-02-26
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] Impact of maraviroc (MVC)-resistant mutations in the C1 and C4 regions of gp120 on sensitivity to antibody-mediated neutralization.
- Author(s)
  Samatchaya Boonchawalit, Shigeyoshi Harada, Shuzo Matsushita, Kazuhisa Yoshimura.
- Organizer
  15th Kumamoto AIDS Seminar
- Place of Presentation
  Kumamoto, Japan
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] CD4類似低分子化合物 (CD4MCs) とgp120.
- Author(s)
  原田恵嘉
- Organizer
  第28回日本エイズ学会学術集会・総会
- Place of Presentation
  大阪
- Year and Date
  2014-12-03 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] Resistance Profile of CD4 Mimic Small Compounds (CD4MCs) and the Structure Analysis by Molecular Dynamic (MD) Simulation.
- Author(s)
  Shigeyoshi Harada, Masaru Yokoyama, Samatchaya Boonchawalit, Hironori Sato, Shuzo Matsushita, Kazuhisa Yoshimura.
- Organizer
  HIV Research for Prevention 2014
- Place of Presentation
  Cape Town, South Africa
- Year and Date
  2014-10-28 – 2014-10-31
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] 新規エントリー阻害剤の組み合わせによる抗ウイルス効果と耐性変異の解析.
- Author(s)
  原田恵嘉.
- Organizer
  第17回日本レトロウイルス研究会夏期セミナー
- Place of Presentation
  静岡
- Year and Date
  2014-07-03 – 2014-07-05
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] CD4類似低分子化合物誘導体 (CD4MCs) の耐性プロファイルと分子動力学的機構解析.
- Author(s)
  原田恵嘉, 横山勝, Samatchaya Boonchawalit, 佐藤裕徳, 松下修三, 吉村和久.
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-24590199
[Presentation] Impact of Maraviroc (MVC)-resistant mutations in C1 and C4 regions of gp120 on sensitivity to antibody-mediated neutralization.
- Author(s)
  amatchaya Boonchawalit, Shigeyoshi Harada, Shuzo Matsushita, Kazuhisa Yoshimura.
- Organizer
  20th International AIDS Conference Melbourne
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2014-07-20 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-24590199

1. NARUMI Tetsuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. TERAHARA Kazutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 俣野哲朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
4. 辻耕平

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 中田浩智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 横田恭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

harada shigeyoshi 原田 恵嘉

HARADA Shigeyoshi 原田 恵嘉

Research Projects

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Co-Researchers

抗体活性増強を基軸とするHIV治癒へ繋ぐADCC活性に関する基盤研究Principal Investigator

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抗HIV薬研究を起点とする新規SARS-CoV-2治療戦略探索とウイルス性状解析Principal Investigator

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Comprehensive study on HIV-specific ADCC responses using library clinical isolatesPrincipal Investigator

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Countermeasure study on HIV Env diversity using library clinical isolatesPrincipal Investigator

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Establishment of in vitro selection system by multi anti-HIV drugsPrincipal Investigator

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Establishment of in vitro selection system using recent primary isolates, and a new efficient treatment for HIVPrincipal Investigator

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[Book] HIVエンベロープの治療標的構造研究：新規治療法における侵入阻害剤と中和抗体の関係2016

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[Journal Article] Late-Stage Derivatization of Oleanolic Acid-Based Anti-HIV-1 Compounds2024

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[Journal Article] Plasmacytoid dendritic cells stimulated with Lactococcus lactis strain Plasma produce soluble factors to suppress SARS-CoV-2 replication2023

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[Journal Article] Hybrids of small CD4 mimics and gp41-related peptides as dual-target HIV entry inhibitors2022

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[Journal Article] Development of a novel Macaque-Tropic HIV-1 adapted to cynomolgus macaques2022

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[Journal Article] Neutralizing-antibody-independent SARS-CoV-2 control correlated with intranasal-vaccine-induced CD8+ T?cell responses2022

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[Journal Article] Association of envelope-specific B-cell differentiation and viral selective pressure signatures in HIV-1 CRF01_AE infection2022

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[Journal Article] Exploratory studies on soluble small molecule CD4 mimics as HIV entry inhibitors2022

harada shigeyoshi 原田恵嘉

HARADA Shigeyoshi 原田恵嘉