MAKIDE Kumiko 巻出久美子

Researcher Number	30519773
Affiliation (based on the past Project Information) *help	2013 – 2016: 東北大学, 薬学研究科(研究院), 助教 2009 – 2011: Tohoku University, 大学院・薬学研究科, 助教
Review Section/Research Field	Principal Investigator Biological pharmacy / Structural biochemistry
Keywords	Principal Investigator リゾリン脂質 / GPCR / 受容体 / 炎症 / 産生酵素 / 自己免疫疾患 / マスト細胞 / 脂質メディエーター / カルシウムチャネル / 脂質メディエーターメディエーター / 腫瘍免疫 / リゾリン脂質メディエーター

リゾホスファチジルセリンを介したがん細胞免疫回避機構の解明Principal Investigator
- Principal Investigator
  
  巻出久美子
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
Target of lysophosphatidylserine on mast cellsPrincipal Investigator
- Principal Investigator
  
  MAKIDE Kumiko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University
Function of lysophosphatidylserine in immune responsePrincipal Investigator
- Principal Investigator
  
  MAKIDE Kumiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tohoku University

All 2016 2015 2014 2012 2011 2010 2009 Other

All Journal Article Presentation Book Patent

[Book] Chronic Inflammation, Lysophosphatidylserine as an Inflammatory Mediator2016
- Author(s)
  Kumiko Makide, Asuka Inoue, Junken Aoki
- Total Pages
  9
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-15K07919
[Journal Article] Conformational Constraint of the Glycerol Moiety of Lysophosphatidylserine Affords Compounds with Receptor Subtype Selectivity.2016
- Author(s)
  Sejin Jung, Asuka Inoue, Sho Nakamura, Takayuki Kishi, Akiharu Uwamizu, Misa Sayama, Masaya Ikubo, Yuko Otani, Kuniyuki Kano, Kumiko Makide, Junken Aoki, Tomohiko Ohwada
- Journal Title
  
  J. Med. Chem.
  
  Volume: 59 Pages: 3750-3776
- DOI
  10.1021/acs.jmedchem.5b01925
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H00822, KAKENHI-PROJECT-16J02800, KAKENHI-PROJECT-16J08059, KAKENHI-PROJECT-15K07919, KAKENHI-PROJECT-16K08157, KAKENHI-PROJECT-16K15113, KAKENHI-PROJECT-16H05085
[Journal Article] GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position.2012
- Author(s)
  Kitamura H, Makide K, Shuto A, Ikubo M, Inoue A, Suzuki K, Sato Y, Nakamura S, Otani Y, Ohwada T, Aoki J
- Journal Title
  
  J. Biochemistry
  
  Volume: 151 Pages: 511-518
- DOI
  10.1093/jb/mvs011
- NAID
  10031166091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390015, KAKENHI-PROJECT-21770102, KAKENHI-PROJECT-22659013, KAKENHI-PROJECT-23790006, KAKENHI-PROJECT-24659025, KAKENHI-PLANNED-22116004
[Journal Article] GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position2012
- Author(s)
  Kitamura H, Makide K, Shuto A, Ikubo M, Inoue A, Suzuki K, Sato Y, Nakamura S, Otani Y, Ohwada T, Aoki J.
- Journal Title
  
  J Biochem
  
  Volume: 151(5) Pages: 511-8
- NAID
  10031166091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770102
[Journal Article] Surface loops of extracellular phospholipase A(1)determine both substrate specificity and preference for lysophospholipids2012
- Author(s)
  Arima N, Inoue A, Makide K, Nonaka T, Aoki J.
- Journal Title
  
  J Lipid Res
  
  Volume: 53(3) Pages: 513-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770102
[Journal Article] Aoki J. Surface loops of extracellular phospholipase A(1)determine both substrate specificity and preference for lysophospholipids2012
- Author(s)
  Arima N, Inoue A., et al
- Journal Title
  
  J.Lipid Res.
  
  Volume: 53 Pages: 513-521
- DOI
  10.1194/jlr.m022400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J06237, KAKENHI-PROJECT-21390015, KAKENHI-PROJECT-21770102, KAKENHI-ORGANIZER-22116001, KAKENHI-PLANNED-22116004, KAKENHI-PROJECT-22659013
[Journal Article] Expression of phosphatidylserine-specific phospholipase A(1) mRNA in human THP-1-derived macrophages2010
- Author(s)
  Hosono H, Homma M, Ogasawara Y, Makide K, Aoki J, Niwata H, Watanabe M, Inoue K, Ohkohchi N, Kohda Y
- Journal Title
  
  Cell Transplant
  
  Volume: 19 Pages: 759-764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770102
[Journal Article] Expression of phosphatidylserine-specific phospholipase A(1)mRNA in human THP-1-derived macrophages2010
- Author(s)
  Hosono H, Homma M, Ogasawara Y, Makide K, Aoki J, Niwata H, Watanabe M, Inoue K, Ohkohchi N, Kohda Y.
- Journal Title
  
  Cell Transplant
  
  Volume: 19(6) Pages: 759-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770102
[Journal Article] Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol2009
- Author(s)
  Makide K, Kitamura H, Sato Y, Okutani M, Aoki J.
- Journal Title
  
  Prostaglandins Other Lipid Mediat
  
  Volume: 89(3-4) Pages: 35-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770102
[Journal Article] Lysophospholipid mediators2009
- Author(s)
  Makide K, Kano K, Kitamura H, Arima N, Aoki J.
- Journal Title
  
  Tanpakushitsu Kakusan Koso
  
  Volume: 54(1) Pages: 29-39
- NAID
  40016392334
- Data Source
  KAKENHI-PROJECT-21770102
[Journal Article] Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative2009
- Author(s)
  Iwashita M, Makide K, Nonomura T, Misumi Y, Otani Y, Ishida M, Taguchi R, Tsujimoto M, Aoki J, Arai H, Ohwada T.
- Journal Title
  
  J Med Chem
  
  Volume: 52(19) Pages: 5837-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770102
[Journal Article] Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophos phatidylthreonine and its 2-deoxy derivative.2009
- Author(s)
  Iwashita M, Makide K, Nonomura T, Misumi Y, Otani Y, Ishida M, Taguchi R, Tsujimoto M, Aoki J, Arai H, Ohwada T.
- Journal Title
  
  J Med Chem. 52
  
  Pages: 5837-5863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770102
[Patent] 自己免疫疾患治療薬のスクリーニング方法2011
- Inventor(s)
  青木淳賢、巻出久美子、井上飛鳥、大和田智彦
- Industrial Property Rights Holder
  東北大学、東京大学
- Industrial Property Number
  2011-112881
- Filing Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] リゾホスファチジルセリンの腫瘍免疫における役割2016
- Author(s)
  巻出久美子
- Organizer
  第17回Pharmaco-Hematology Symposium
- Place of Presentation
  帝京大学（東京）
- Year and Date
  2016-09-03
- Invited
- Data Source
  KAKENHI-PROJECT-15K07919
[Presentation] 腫瘍免疫におけるリゾホスファチジルセリンの役割2016
- Author(s)
  巻出久美子、新上雄司、井上飛鳥、青木淳賢
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター、東北大学（仙台）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15K07919
[Presentation] CRISPR/Cas9システムを用いたLysoPS受容体TKOマウスの作製2015
- Author(s)
  新上雄司、井上飛鳥、巻出久美子、中島修、青木淳賢
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K07919
[Presentation] マスト細胞上のリゾホスファチジルセリン受容体の同定2014
- Author(s)
  川名裕己、井上飛鳥、巻出久美子、青木淳賢
- Organizer
  第7回リピッド合同カンファレンス
- Place of Presentation
  札幌
- Year and Date
  2014-09-18
- Data Source
  KAKENHI-PROJECT-25860041
[Presentation] 新規LysoPS受容体の同定2012
- Author(s)
  奥谷倫世、井上飛鳥、巻出久美子、三枝大輔、富岡佳久、青木淳賢
- Organizer
  新学術領域若手ワークショップ
- Place of Presentation
  東京大学
- Year and Date
  2012-02-01
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] リゾホスファチジルセリンによる免疫抑制作用2012
- Author(s)
  巻出久美子、北村一、井上飛鳥、青木淳賢
- Organizer
  新学術領域若手ワークショップ
- Place of Presentation
  東京大学
- Year and Date
  2012-02-01
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] 生体内におけるリゾホスファチジルセリンの検出2012
- Author(s)
  奥谷倫世、井上飛鳥、巻出久美子、三枝大輔、富岡佳久、青木淳賢
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] リゾホスファチジルセリンによる免疫抑制作用2012
- Author(s)
  巻出久美子, 他
- Organizer
  新学術領域若手ワークショップ
- Place of Presentation
  東京
- Year and Date
  2012-02-01
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] リゾホスファチジルセリンは自己免疫性肝炎を緩和させる2012
- Author(s)
  鈴木健介、北村一、奥谷倫世、首藤啓明、巻出久美子、井上飛鳥、青木淳賢
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] Role of lysophosphatidylserine in inflammation-associated mast cell degranulation2011
- Author(s)
  Kumiko Makide, Michiyo Okutani, Asuka Inoue, Junken Aoki
- Organizer
  第33回内藤コンファレンス
- Place of Presentation
  シャトレーゼガトーキングダムサッポロ
- Year and Date
  2011-06-29
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] リゾホスファチジルセリンの細胞接着抑制作用2011
- Author(s)
  北村一、奥谷倫世、首藤啓明、井上飛鳥、巻出久美子、大和田智彦、青木淳賢
- Organizer
  第84回日本生化学大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] 2-アシル型リゾリン脂質の検出とその受容体活性化機構の解析2011
- Author(s)
  首藤啓明、井上飛鳥、奥谷倫世、巻出久美子、青木淳賢
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] Immunosuppressive roles of lysophosphatidylserine in mice2011
- Author(s)
  Kumiko Makide, 他
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  千葉
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] リゾホスファチジルセリンの免疫抑制作用2011
- Author(s)
  奥谷倫世、北村一、巻出久美子、井上飛鳥、椛島健治、青木淳賢
- Organizer
  第84回日本生化学大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] Effects of lysophosphatidylserine on lymphocytes2011
- Author(s)
  Kumiko Makide, Hajime Kitamura, Junken Aoki
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] Role of lysophosphatidylserine in inflammation-associated mast cell degranulation2011
- Author(s)
  Kumiko Makide, 他
- Organizer
  第30回内藤コンファレンス
- Place of Presentation
  札幌
- Year and Date
  2011-06-28
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] 2-アシル型リゾリン脂質の検出とその受容体活性化機構の解析2011
- Author(s)
  首藤啓明、井上飛鳥、奥谷倫世、巻出久美子、青木淳賢
- Organizer
  次世代を担う若手ファーマ・バイオフォーラム2011
- Place of Presentation
  東北大学さくらホール
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] ホスホリパーゼA1(PLA1)により産生される2-アシル型リゾリン脂質の分離とその性状解析2011
- Author(s)
  首藤啓明、井上飛鳥、奥谷倫世、北村一、有馬直明、巻出久美子、青木淳賢
- Organizer
  第53回日本脂質生化学会
- Place of Presentation
  ホテル東京ガーデンパレス
- Year and Date
  2011-05-12
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] リゾホスファチジルセリンの活性化リンパ球に対する効果2010
- Author(s)
  北村一、巻出久美子、井上飛鳥、青木淳賢
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] LPS受容体P2Y10の同定と細胞接着における機能2010
- Author(s)
  北村一、巻出久美子、井上飛鳥、青木淳賢
- Organizer
  第9回次世代を担う若手ファーマ・バイオフォーラム2010
- Place of Presentation
  京都大学大学院薬学研究科
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] ホスファチジルセリン特異的ホスホリパーゼA1の病理的機能の解明2010
- Author(s)
  佐藤佑介、巻出久美子、青木淳賢
- Organizer
  第49回日本薬学会東北支部大会
- Place of Presentation
  奥羽大学
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] LC-ESI-MS/MSを用いたリゾホスファチジルセリンおよびリゾホスファチジルスレオニンの検出2010
- Author(s)
  奥谷倫世、井上飛鳥、巻出久美子、三枝大輔、富岡佳久、青木淳賢
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] LC-ESI-MS/MSを用いたリゾホスファチジルセリンの検出2010
- Author(s)
  奥谷倫世、井上飛鳥、巻出久美子、三枝大輔、富岡佳久、青木淳賢
- Organizer
  第49回日本薬学会東北支部大会
- Place of Presentation
  奥羽大学
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] 炎症反応のマスト細胞活性化におけるリゾホスファチジルセリンの役割2010
- Author(s)
  巻出久美子、奥谷倫世、井上飛鳥、青木淳賢
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21770102
[Presentation] ラット腹腔マスト細胞におけるTRPチャネルの発現解析
- Author(s)
  川名裕己、井上飛鳥、巻出久美子、青木淳賢
- Organizer
  第52回日本薬学会東北支部大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25860041

1. OTANI Yuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. Ohwada Tomohiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 青木淳賢

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

MAKIDE Kumiko 巻出 久美子

Research Projects

Research Products

Co-Researchers

リゾホスファチジルセリンを介したがん細胞免疫回避機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Target of lysophosphatidylserine on mast cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Function of lysophosphatidylserine in immune responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Chronic Inflammation, Lysophosphatidylserine as an Inflammatory Mediator2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Conformational Constraint of the Glycerol Moiety of Lysophosphatidylserine Affords Compounds with Receptor Subtype Selectivity.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position.2012

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Surface loops of extracellular phospholipase A(1)determine both substrate specificity and preference for lysophospholipids2012

Author(s)

Journal Title

Data Source

[Journal Article] Aoki J. Surface loops of extracellular phospholipase A(1)determine both substrate specificity and preference for lysophospholipids2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of phosphatidylserine-specific phospholipase A(1) mRNA in human THP-1-derived macrophages2010

Author(s)

Journal Title

Data Source

[Journal Article] Expression of phosphatidylserine-specific phospholipase A(1)mRNA in human THP-1-derived macrophages2010

Author(s)

Journal Title

Data Source

[Journal Article] Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol2009

Author(s)

Journal Title

Data Source

[Journal Article] Lysophospholipid mediators2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophosphatidylthreonine and its 2-deoxy derivative2009

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis and evaluation of lysophosphatidylserine analogues as inducers of mast cell degranulation. Potent activities of lysophos phatidylthreonine and its 2-deoxy derivative.2009

Author(s)

Journal Title

Data Source

[Patent] 自己免疫疾患治療薬のスクリーニング方法2011

Inventor(s)

Industrial Property Rights Holder

MAKIDE Kumiko 巻出久美子