Makiyama Takeru 牧山武

… Alternative Names

MAKIYAMA Takeru 牧山武

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Researcher Number	30528302
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 講師
Affiliation (based on the past Project Information) *help	2025: 京都大学, 医学研究科, 講師 2019 – 2024: 京都大学, 医学研究科, 特定講師 2016 – 2019: 京都大学, 医学研究科, 助教 2015: 京都大学, 大学院医学研究科, 助教 2011 – 2015: 京都大学, 医学(系)研究科(研究院), 助教 2012: 京都大学, 医学研究科, 助教 2009 – 2010: Kyoto University, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine / Circulatory organs internal medicine Except Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine / Basic Section 52050:Embryonic medicine and pediatrics-related / Circulatory organs internal medicine
Keywords	Principal Investigator 不整脈 / iPS細胞 / 疾患モデル / 遺伝子 / 心筋細胞 / カルモジュリン / 遺伝性不整脈 / 心筋症 / イオンチャネル / 分子心臓病態学 … More / 遺伝子編集 / 洞不全症候群 / リアノジン受容体 / 薬理学 / 生理学 / 分子心臓学 / ゲノム編集 / 遺伝子治療 / QT延長症候群 / 突然死 / 遺伝学 / 臨床心臓学 … More Except Principal Investigator 心臓突然死 / 遺伝性不整脈 / 遺伝子変異 / ブルガダ症候群 / ノックインマウス / エピジェネティクス / バイオインフォマティクス / 突然死 / Na/Ca交換体 / コンピュータシミュレーション / 致死性不整脈 / ゲノム編集 / パッチクランプ / QT短縮症候群 / 早期再分極症候群 / トランスポータ / Na-Ca交換体 / 全ゲノム解析 / 低頻度バリアント / 人種横断メタ解析 / ゲノムワイド関連解析 / L型カルシウムチャネル / 先天性QT延長症候群 / QT延長症候群 / イオンチャネル / カルシウム電流 / シグナル伝達 / エピゲノム / 心不全 / 洞不全症候群 / 全ゲノムシークエンス / 変異 / 膜タンパク / 特発性心室細動 / 機能実験 / 遺伝子検査 / 疾患遺伝子関連 / 拡張型心筋症 / モデル / iPS細胞 / TTN / RBM20 / TCAP / z-ライン / 心筋症 / DNA構造多型 / DNA構造異常 / long read sequencer / ゲノム構造多型 / ゲノムDNA構造異常 / J波症候群 / 分子心臓学 / 内科 / カルモジュリン / 心室細動 / J波 / SCN5A / コピー数変動 / 循環器・高血圧 / 機能解析 / 遺伝子 / 遺伝学 / 高血圧 / 循環器 / CRISPR/CAS / CRISPR/cas9 / 心臓伝導障害 / CRISPR/Cas9 / 進行性心臓伝導障害 / コラーゲン / neoatherosclerosis / 心筋梗塞 / 狭心症 / 血栓 / ステント / 動脈硬化 / 分子心臓病態度学 / 分子心臓病態学 / 不整脈 Less

International collaborative meta-analysis of trans-ethnic studies to identify sudden death risk genes in Brugada syndrome
- Principal Investigator
  
  石川泰輔
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kagoshima University
Bioinformatics analysis of non-coding DNA regions to elucidate the pathogenic mechanism of inherited arrhythmias
- Principal Investigator
  
  村田広茂
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Nippon Medical School
Investigation of Cardiac Epigenomic Circuit in the Development of Heart Failure and Identification of Potential Therapeutic Targets
- Principal Investigator
  
  桑原宏一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Shinshu University
QT延長とブルガダ症候群の合併を来すCa2+チャネル変異の機序解明を目指す研究
- Principal Investigator
  
  加藤浩一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Shiga University of Medical Science
Study of familial sinoatrial node dysfunction using iPS cell-derived subtype-specific cardiomyocytesPrincipal Investigator
- Principal Investigator
  
  牧山武
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kyoto University
バイオインフォマティクスを用いた非コードDNA解析による若年突然死の発症機序解明
- Principal Investigator
  
  村田広茂
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Nippon Medical School
The elucidation of complicated genetic backgrounds and pathogenicity in patients with inherited primary arrhythmia syndromes caused by unknown etiology
- Principal Investigator
  
  大野聖子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Cardiovascular Center Research Institute
臨床予後予測に向けたiPS細胞由来心筋症モデルによる特発性拡張型心筋症の病態解明
- Principal Investigator
  
  藍智彦
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Juntendo University
Elucidation of molecular pathogenesis for inherited lethal arrhythmia associated with transporter abnormalities
- Principal Investigator
  
  石川泰輔
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Elucidation of the pathogenesis of lethal inherited arrhythmias using iPS cells and development of therapeutic approachesPrincipal Investigator
- Principal Investigator
  
  Makiyama Takeru
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kyoto University
Novel molecular basis underlying lethal arrhythmic syndrome due to mutations in cardiac Na/Ca exchanger gene
- Principal Investigator
  
  MAKITA Naomasa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Modeling Inherited Arrhythmia Disorders Using Patient-Derived Induced Pluripotent Stem CellsPrincipal Investigator
- Principal Investigator
  
  Makiyama Takeru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kyoto University
Novel molecular basis of cardriac conduction disturbance associated with a collagene gene mutation
- Principal Investigator
  
  MAKITA Naomasa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Nagasaki University
Multilateral Research on the Mechanisms of Inherited Arrhythmias
- Principal Investigator
  
  Horie Minoru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Shiga University of Medical Science
Elucidation of novel pathophysiology underlysing lethal arrhythmia due to mutations in cardiac ion transporters
- Principal Investigator
  
  MAKITA Naomasa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Nagasaki University
Elucidation of the mechanism of neoatherosclerosis
- Principal Investigator
  
  KIMURA Takeshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kyoto University
Genetic background of inherited cardiac arrhythmiasPrincipal Investigator
- Principal Investigator
  
  Makiyama Takeru
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kyoto University
New approach to analyze inherited arrhythmias using human iPS cells
- Principal Investigator
  
  KIMURA Takeshi
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto University
Genetic backgrounds of inherited arrhythmias -disease specific human iPS cells-Principal Investigator
- Principal Investigator
  
  MAKIYAMA Takeru
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto University
Analysis of the pathogenesis of cardiac Na channelopathiesPrincipal Investigator
- Principal Investigator
  
  MAKIYAMA Takeru
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyoto University

[Journal Article] Clinical characterization of type 1 long QT syndrome caused by C-terminus Kv7.1 variants2024
- Author(s)
  Kashiwa A, Itoh H, Makiyama T, Wada Y, Ozawa J, Kato K, Fukuyama M, Nakajima T, Ohno S, Horie M.
- Journal Title
  
  Heart Rhythm
  
  Volume: In press Issue: 7 Pages: 1113-1120
- DOI
  10.1016/j.hrthm.2024.02.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08179, KAKENHI-PROJECT-23K06845, KAKENHI-PROJECT-23K07528, KAKENHI-PROJECT-20K08473
[Journal Article] KUS121, a VCP modulator, has an ameliorating effect on acute and chronic heart failure without calcium loading via maintenance of intracellular ATP levels2023
- Author(s)
  Tsuji S, Otani C, Horie T, Watanabe S, Baba O, Sowa N, Ide Y, Kashiwa A, Makiyama T, Imai H, Nakashima Y, Yamasaki T, Xu S, Matsushita K, Suzuki K, Zou F, Kume E, Hasegawa K, Kimura T, Kakizuka A, Ono K.
- Journal Title
  
  Biomed Pharmacother
  
  Volume: 170 Pages: 115850-115850
- DOI
  10.1016/j.biopha.2023.115850
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07575, KAKENHI-PROJECT-22K16071
[Journal Article] iPS 細胞を用いた遺伝性不整脈疾患研究の最先端：患者由来iPS 細胞を用いた遺伝性不整脈疾患研究　遺伝性不整脈研究の進歩と臨床応用2023
- Author(s)
  牧山　武
- Journal Title
  
  心臓
  
  Volume: 55
- Data Source
  KAKENHI-PROJECT-23K07575
[Journal Article] Non-missense variants of KCNH2 show better outcomes in type 2 long QT syndrome2023
- Author(s)
 Aizawa Takanori、Wada Yuko、Hasegawa Kanae、Huang Hai、Imamura Tomohiko、Gao Jingshan、Kashiwa Asami、Kohjitani Hirohiko、Fukuyama Megumi、Kato Koichi、Kato Eri Toda、Hisamatsu Takashi、Ohno Seiko、Makiyama Takeru、Kimura Takeshi、Horie Minoru
- Journal Title
 
 EP Europace
 
 Volume: 25 Issue: 4 Pages: 1491-1499
- DOI
 10.1093/europace/euac269
- Data Source
 KAKENHI-PROJECT-21H02888, KAKENHI-PROJECT-20K17113, KAKENHI-PROJECT-23K07575
[Journal Article] Calmodulinopathy in Japanese Children　― Their Cardiac Phenotypes Are Severe and Show Early Onset in Fetal Life and Infancy ―2023
- Author(s)
  Megumi Fukuyama, Minoru Horie, Koichi Kato, Seiko Ohno, et al.
- Journal Title
  
  Circ J
  
  Volume: 87 Issue: 12 Pages: 1828-1835
- DOI
  10.1253/circj.CJ-23-0195
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2023-11-24
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08179, KAKENHI-PROJECT-23K07528, KAKENHI-PROJECT-23K07575
[Journal Article] School-based routine screenings of electrocardiograms for the diagnosis of long QT syndrome2022
- Author(s)
  Fukuyama Megumi、Horie Minoru、Aoki Hisaaki、Ozawa Junichi、Kato Koichi、Sawayama Yuichi、Tanaka-Mizuno Sachiko、Makiyama Takeru、Yoshinaga Masao、Nakagawa Yoshihisa、Ohno Seiko
- Journal Title
  
  EP Europace
  
  Volume: - Issue: 9 Pages: 1496-1503
- DOI
  10.1093/europace/euab320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-19K08555, KAKENHI-PROJECT-20K17113, KAKENHI-PROJECT-21H02888
[Journal Article] JCS/JHRS 2020 Guideline on Pharmacotherapy of Cardiac Arrhythmias2022
- Author(s)
  Ono K, Iwasaki YK, Akao M, Makiyama T, Maruyama M, Miake J, Muraji S, Murata H, Morita N, Yokoshiki H, Yoshioka K, Yodogawa K, Inoue H, Okumura K, Kimura T, Tsutsui H, Shimizu W
- Journal Title
  
  Circ J
  
  Volume: 86 Issue: 11 Pages: 1790-1924
- DOI
  10.1253/circj.CJ-20-1212
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2022-10-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-19K08566, KAKENHI-PROJECT-20K08473, KAKENHI-PROJECT-20K20662
[Journal Article] Increased CaV1.2 late current by a CACNA1C p.R412M variant causes an atypical Timothy syndrome without syndactyly.2022
- Author(s)
  Ozawa J, Ohno S, Melgari D, Wang Q, Fukuyama M, Toyoda F, Makiyama T, Yoshinaga M, Suzuki H, Saitoh A, Ai T, Horie M.
- Journal Title
  
  Sci Rep
  
  Volume: 12 Issue: 1 Pages: 18984-18984
- DOI
  10.1038/s41598-022-23512-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08900, KAKENHI-PROJECT-21K06781, KAKENHI-PROJECT-21K08135, KAKENHI-PROJECT-22K07840, KAKENHI-PROJECT-22K08179, KAKENHI-PROJECT-21H02888
[Journal Article] Oral Adrenergic Agents Produced Ventricular Fibrillation and QT Prolongation in an Elderly Patient Carrying an RYR2 Variant2022
- Author(s)
 Hasegawa Kanae、Gao Jingshan、Ohno Seiko、Ishida Kentaro、Miyazaki Shinsuke、Makiyama Takeru、Horie Minoru、Uzui Hiroyasu、Tada Hiroshi
- Journal Title
 
 Int. Heart J.
 
 Volume: 63 Issue: 2 Pages: 398-403
- DOI
 10.1536/ihj.21-543
- ISSN
 1349-2365, 1349-3299
- Year and Date
 2022-03-30
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-19K08538
[Journal Article] Impact of cascade screening for catecholaminergic polymorphic ventricular tachycardia type 12022
- Author(s)
  Shimamoto K, Ohno S, Kato K, Takayama K, Sonoda K, Fukuyama M, Makiyama T, Okamura S, Asakura K, Imanishi N, Kato Y, Sakaguchi H, Kamakura T, Wada M, Yamagata K, Ishibashi K, Inoue Y, Miyamoto K, Nagase S, Kusano K, Horie M, Aiba T.
- Journal Title
  
  Heart
  
  Volume: - Issue: 11 Pages: 2021-320220
- DOI
  10.1136/heartjnl-2021-320220
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-19K08555, KAKENHI-PROJECT-21H02888, KAKENHI-PROJECT-21K07765, KAKENHI-PROJECT-19K08505, KAKENHI-PROJECT-19K17581
[Journal Article] Association Between Deleterious SCN5A Variants and Ventricular Septal Defect in Young Patients With Brugada Syndrome2022
- Author(s)
  Suzuki Keisuke、Sonoda Keiko、Aoki Hisaaki、Nakamura Yuko、Watanabe Seiichi、Yoshida Yoko、Hoshino Kenji、Ozawa Junichi、Imamura Tomohiko、Aiba Takeshi、Kato Koichi、Makiyama Takeru、Kusano Kengo、Horie Minoru、Ohno Seiko
- Journal Title
  
  JACC: Clinical Electrophysiology
  
  Volume: 8 Issue: 3 Pages: 297-305
- DOI
  10.1016/j.jacep.2022.01.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-21H02888, KAKENHI-PROJECT-19K08505, KAKENHI-PROJECT-19K17581
[Journal Article] Laminopathyモデル2021
- Author(s)
  牧山　武、烏日揚海伊敏、黄　海
- Journal Title
  
  疾患モデルの作製と利用―循環器疾患2021
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-19K08538
[Journal Article] Impact of the T-wave characteristics on distinguishing arrhythmogenic right ventricular cardiomyopathy from healthy children2021
- Author(s)
  Imamura Tomohiko、Sumitomo Naokata、Muraji Shota、Yasuda Kazushi、Nishihara Eiki、Iwamoto Mari、Tateno Shigeru、Doi Shozaburo、Hata Tadayoshi、Kogaki Shigetoyo、Horigome Hitoshi、Ohno Seiko、Ichida Fukiko、Nagashima Masami、Makiyama Takeru、Yoshinaga Masao
- Journal Title
  
  International Journal of Cardiology
  
  Volume: 323 Pages: 168-174
- DOI
  10.1016/j.ijcard.2020.08.088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-18H02808, KAKENHI-PROJECT-18K07813, KAKENHI-PROJECT-18K07875, KAKENHI-PROJECT-18K02505, KAKENHI-PROJECT-18K07785
[Journal Article] 【特集/不整脈診療・治療の最新のトピックス】『解説4．iPS心筋細胞の基礎と不整脈、心電学への応用最前線』ヒトiPS細胞モデルを用いた遺伝性不整脈疾患の基礎研究－診断、発症機序解明、新規治療法開発―2021
- Author(s)
  牧山　武、山本　雄太、吉永　大介、廣瀬　紗也子、相澤卓範、柏　麻美、高景山、今村知彦、黄海、糀谷　泰彦
- Journal Title
  
  循環器内科
  
  Volume: 90(4) Pages: 483-490
- Data Source
  KAKENHI-PROJECT-19K08538
[Journal Article] Pueraria mirifica , an estrogenic tropical herb, unveiled the severity of Type 1 LQTS caused by KCNQ1 ‐T587M2021
- Author(s)
 Kashiwa Asami、Hosaka Yukio、Takahashi Kazuyoshi、Ohno Seiko、Wada Yuko、Makiyama Takeru、Oda Hirotaka、Horie Minoru
- Journal Title
 
 Journal of Arrhythmia
 
 Volume: 37 Issue: 4 Pages: 1114-1116
- DOI
 10.1002/joa3.12576
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-19K08538
[Journal Article] Corrigendum to “A challenge for mutation specific risk stratification in long QT syndrome type 1” [J. Cardiol. 72(1) (2018) 56?65]2021
- Author(s)
  Yagi Noriaki、Itoh Hideki、Hisamatsu Takashi、Tomita Yukinori、Kimura Hiromi、Fujii Yusuke、Makiyama Takeru、Horie Minoru、Ohno Seiko
- Journal Title
  
  Journal of Cardiology
  
  Volume: 77 Issue: 3 Pages: 322-326
- DOI
  10.1016/j.jjcc.2020.09.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08538
[Journal Article] Loss-of-function mutations in cardiac ryanodine receptor channel cause various types of arrhythmias including long QT syndrome2021
- Author(s)
  Hirose Sayako、Murayama Takashi、Tetsuo Naoyuki、Hoshiai Minako、Kise Hiroaki、Yoshinaga Masao、Aoki Hisaaki、Fukuyama Megumi、Wuriyanghai Yimin、Wada Yuko、Kato Koichi、Makiyama Takeru、Kimura Takeshi、Sakurai Takashi、Horie Minoru、Kurebayashi Nagomi、Ohno Seiko
- Journal Title
  
  EP Europace
  
  Volume: 24 Issue: 3 Pages: 497-510
- DOI
  10.1093/europace/euab250
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-19K08555, KAKENHI-PROJECT-21H02888, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-20K17113, KAKENHI-PROJECT-19H03404
[Journal Article] SCN5A mutation identified in a patient with short-coupled variant of torsades de pointes2020
- Author(s)
  Sonoda Keiko、Ohno Seiko、Shimizu Yukiko、Kaitani Kazuaki、Makiyama Takeru、Nakagawa Yoshihisa、Horie Minoru
- Journal Title
  
  Pacing and Clinical Electrophysiology
  
  Volume: - Issue: 5 Pages: 456-461
- DOI
  10.1111/pace.13924
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17581, KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-18K07875
[Journal Article] Erratum to “Optical Recording of Action Potentials in Human Induced Pluripotent Stem Cell-Derived Cardiac Single Cells and Monolayers Generated from Long QT Syndrome Type 1 Patients”2020
- Author(s)
  Takaki T, Inagaki A, Chonabayashi K, Inoue K, Miki K, Ohno S, Makiyama T, Horie M, Yoshida Y.
- Journal Title
  
  Stem Cells International
  
  Volume: 2020 Pages: 1-2
- DOI
  10.1155/2020/8765895
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02808, KAKENHI-PROJECT-20K08416
[Journal Article] LMNA Missense Mutation Causes Nonsense-Mediated mRNA Decay and Severe Dilated Cardiomyopathy2020
- Author(s)
  Kato Koichi、Ohno Seiko、Sonoda Keiko、Fukuyama Megumi、Makiyama Takeru、Ozawa Tomoya、Horie Minoru
- Journal Title
  
  Circulation: Genomic and Precision Medicine
  
  Volume: 13 Issue: 5 Pages: 435-443
- DOI
  10.1161/circgen.119.002853
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-19K08555, KAKENHI-PROJECT-19K17581, KAKENHI-PROJECT-18K07875
[Journal Article] Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome2020
- Author(s)
  Lahrouchi N, Tadros R, Crotti L, Makiyama T et al.
- Journal Title
  
  Circulation
  
  Volume: 142 Issue: 4 Pages: 324-338
- DOI
  10.1161/circulationaha.120.045956
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-20K08473, KAKENHI-PROJECT-18KK0245, KAKENHI-PROJECT-18H02808, KAKENHI-PROJECT-18K07875, KAKENHI-PROJECT-18K19550, KAKENHI-PROJECT-20K08416
[Journal Article] Propranolol Attenuates Late Sodium Current in a Long QT Syndrome Type 3-Human Induced Pluripotent Stem Cell Model2020
- Author(s)
  Hirose Sayako、Makiyama Takeru、Melgari Dario、Yamamoto Yuta、Wuriyanghai Yimin、Yokoi Fumika、Nishiuchi Suguru、Harita Takeshi、Hayano Mamoru、Kohjitani Hirohiko、Gao Jingshan、Kashiwa Asami、Nishikawa Misato、Wu Jie、Yoshimoto Jun、Chonabayashi Kazuhisa、Ohno Seiko、Yoshida Yoshinori、Horie Minoru、Kimura Takeshi
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 8 Pages: 761-761
- DOI
  10.3389/fcell.2020.00761
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-18H02808, KAKENHI-PROJECT-18K07875, KAKENHI-PROJECT-19K17595, KAKENHI-PROJECT-17H04176
[Journal Article] Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls2020
- Author(s)
  2.Walsh R, Lahrouchi N, Tadros R, Kyndt F, Glinge C, Postema PG, et al.
- Journal Title
  
  Genetics in Medicine
  
  Volume: 23 Issue: 1 Pages: 47-58
- DOI
  10.1038/s41436-020-00946-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08505, KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-20K08473, KAKENHI-PROJECT-18H02808, KAKENHI-PROJECT-18K07875, KAKENHI-PROJECT-18K08100, KAKENHI-PROJECT-18K19550, KAKENHI-PROJECT-18K15407, KAKENHI-PROJECT-18KK0245, KAKENHI-PROJECT-21H02888, KAKENHI-PROJECT-21H02920, KAKENHI-PROJECT-20K08416
[Journal Article] An NGS-based genotyping in LQTS; minor genes are no longer minor2020
- Author(s)
  Ohno Seiko、Ozawa Junichi、Fukuyama Megumi、Makiyama Takeru、Horie Minoru
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 65 Issue: 12 Pages: 1083-1091
- DOI
  10.1038/s10038-020-0805-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-19K08555, KAKENHI-PROJECT-18K07875
[Journal Article] Telethonin variants found in Brugada syndrome, J-wave pattern ECG, and ARVC reduce peak Nav 1.5 currents in HEK-293 cells2020
- Author(s)
  Turker I, Makiyama T, Ueyama T, Shimizu A, Yamakawa M, Chen PS, Vatta M, Horie M, Ai T
- Journal Title
  
  Pacing Clin Electrophysiol
  
  Volume: 43 Issue: 8 Pages: 838-846
- DOI
  10.1111/pace.13996
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08900, KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-18H02808, KAKENHI-PROJECT-20K08416
[Journal Article] Calmodulinopathy(カルモジュリン遺伝子関連不整脈疾患) iPS細胞技術を用いた疾患モデルの作製と遺伝子治療へのアプローチ2019
- Author(s)
  山本雄大,牧山武
- Journal Title
  
  心電図
  
  Volume: 39 Pages: 273-282
- NAID
  130007903608
- Data Source
  KAKENHI-PROJECT-19K08538
[Journal Article] Mutant KCNJ3 and KCNJ5 potassium channels as novel molecular targets in bradyarrhythmias and atrial fibrillation.2019
- Author(s)
  Yamada N, Asano Y, Fujita M, Yamazaki S, Inanobe A, Matsuura N, Kobayashi H, Ohno S, Ebana Y, Tsukamoto O, Ishino S, Takuwa A, Kioka H, Yamashita T, Hashimoto N, Zankov DP, Shimizu A, Asakura M, Asanuma H, Kato H, Nishida Y, Miyashita Y, Shinomiya H, Naiki N, Hayashi K, Makiyama T, Ogita H, et al.
- Journal Title
  
  Circulation
  
  Volume: In press Issue: 18 Pages: 2157-2169
- DOI
  10.1161/circulationaha.118.036761
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08627, KAKENHI-PROJECT-17K08657, KAKENHI-PROJECT-17K09577, KAKENHI-PROJECT-17K09578, KAKENHI-PROJECT-18K07875, KAKENHI-PROJECT-18K08100, KAKENHI-PROJECT-17F17418, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-15KK0302, KAKENHI-PROJECT-17K07251, KAKENHI-PROJECT-18K08033, KAKENHI-PROJECT-19K08538, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H01560, KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-17H04018, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H04074, KAKENHI-PROJECT-18H02803, KAKENHI-PROJECT-18H02808, KAKENHI-PROJECT-18K19547, KAKENHI-PROJECT-19H03652
[Journal Article] A de novo gain-of-function KCND3 mutation in early repolarization syndrome2019
- Author(s)
  Takayama Koichiro、Ohno Seiko、Ding Wei-Guang、Ashihara Takashi、Fukumoto Daisuke、Wada Yuko、Makiyama Takeru、Kise Hiroaki、Hoshiai Minako、Matsuura Hiroshi、Horie Minoru
- Journal Title
  
  Heart Rhythm
  
  Volume: 16 Issue: 11 Pages: 1698-1706
- DOI
  10.1016/j.hrthm.2019.05.033
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07875, KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-19K17593, KAKENHI-PROJECT-17K08536, KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18H02808
[Journal Article] Optical Recording of Action Potentials in Human Induced Pluripotent Stem Cell-Derived Cardiac Single Cells and Monolayers Generated from Long QT Syndrome Type 1 Patients2019
- Author(s)
  Takaki Tadashi、Inagaki Azusa、Chonabayashi Kazuhisa、Inoue Keiji、Miki Kenji、Ohno Seiko、Makiyama Takeru、Horie Minoru、Yoshida Yoshinori
- Journal Title
  
  Stem Cells International
  
  Volume: 2019 Pages: 1-12
- DOI
  10.1155/2019/7532657
- NAID
  120006634620
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-17H04176, KAKENHI-PROJECT-18H02808
[Journal Article] Expertise ヒトiPS細胞由来心筋細胞の電気生理学 (特集心臓電気生理を理解して不整脈診療に活かす) iPS cell-derived cardiomyocytes as a platform for research on inherited arrhythmias2019
- Author(s)
  堀江稔,Wuriyanghai Yimin,牧山武
- Journal Title
  
  Heart view
  
  Volume: 23 Pages: 578-585
- Data Source
  KAKENHI-PROJECT-19K08538
[Journal Article] Association of Genetic and Clinical Aspects of Congenital Long QT Syndrome With Life-Threatening Arrhythmias in Japanese Patients2019
- Author(s)
  Shimizu Wataru、Makimoto Hisaki、Yamagata Kenichiro、Kamakura Tsukasa、Wada Mitsuru、Miyamoto Koji、Inoue-Yamada Yuko、Okamura Hideo、Ishibashi Kohei、Noda Takashi、Nagase Satoshi、Miyazaki Aya、Sakaguchi Heima、Shiraishi Isao、Makiyama Takeru、Ohno Seiko、Itoh Hideki、et al
- Journal Title
  
  JAMA Cardiology
  
  Volume: in press Issue: 3 Pages: 246-254
- DOI
  10.1001/jamacardio.2018.4925
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09494, KAKENHI-PROJECT-18K08100, KAKENHI-PROJECT-18K19550, KAKENHI-PROJECT-18KK0245, KAKENHI-PROJECT-16K09499, KAKENHI-PROJECT-15KK0302, KAKENHI-PROJECT-15H04823, KAKENHI-PROJECT-17K09524, KAKENHI-PROJECT-18K07875, KAKENHI-PROJECT-18K08075, KAKENHI-PROJECT-19K08566, KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-18H02808
[Journal Article] Phenotype-Based High-Throughput Classification of Long QT Syndrome Subtypes Using Human Induced Pluripotent Stem Cells2019
- Author(s)
  Yoshinaga Daisuke、Baba Shiro、Makiyama Takeru、Shibata Hirofumi、Hirata Takuya、Akagi Kentaro、Matsuda Koichi、Kohjitani Hirohiko、Wuriyanghai Yimin、Umeda Katsutsugu、Yamamoto Yuta、Conklin Bruce R.、Horie Minoru、Takita Junko、Heike Toshio
- Journal Title
  
  Stem Cell Reports
  
  Volume: 13 Issue: 2 Pages: 394-404
- DOI
  10.1016/j.stemcr.2019.06.007
- NAID
  120006786948
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-19K17595, KAKENHI-PROJECT-17H04224, KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-18K19467, KAKENHI-PROJECT-18K15847, KAKENHI-PROJECT-18H02808
[Journal Article] ブルガダ症候群におけるアルコール代謝酵素の遺伝子変異飲酒後の失神に関する知見(Genetic Variants of Alcohol-Metabolizing Enzymes in Brugada Syndrome: Insights into Syncope after Drinking Alcohol)2019
- Author(s)
  Qi Wu,Hideki Hayashi,Daiki Hira,Keiko Sonoda,Satoshi Ueshima,Seiko Ohno,Takeru Makiyama,Tomohiro Terada,Toshiya Katsura,Katsuyuki Miura,Minoru Horie
- Journal Title
  
  Journal of Arrhythmia
  
  Volume: 35 Pages: 752-759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08538
[Journal Article] Copy number variations of SCN5A in Brugada syndrome2018
- Author(s)
  Sonoda Keiko、Ohno Seiko、Ozawa Junichi、Hayano Mamoru、Hattori Tetsuhisa、Kobori Atsushi、Yahata Mitsuhiko、Aburadani Isao、Watanabe Seiichi、Matsumoto Yuichi、Makiyama Takeru、Horie Minoru
- Journal Title
  
  Heart Rhythm
  
  Volume: - Issue: 8 Pages: 1179-1188
- DOI
  10.1016/j.hrthm.2018.03.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09499, KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-15K09689, KAKENHI-PROJECT-18K07875
[Journal Article] Differential Diagnosis Between Catecholaminergic Polymorphic Ventricular Tachycardia and Long QT Syndrome Type 1　― Modified Schwartz Score ―2018
- Author(s)
  Ozawa Junichi、Ohno Seiko、Fujii Yusuke、Makiyama Takeru、Suzuki Hiroshi、Saitoh Akihiko、Horie Minoru
- Journal Title
  
  Circ J
  
  Volume: 82 Issue: 9 Pages: 2269-2276
- DOI
  10.1253/circj.CJ-17-1032
- NAID
  130007438837
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2018-08-24
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-18K07875, KAKENHI-PROJECT-16K09499
[Journal Article] A challenge for mutation specific risk stratification in long QT syndrome type 12018
- Author(s)
  Yagi Noriaki、Itoh Hideki、Hisamatsu Takashi、Tomita Yukinori、Kimura Hiromi、Fujii Yusuke、Makiyama Takeru、Horie Minoru、Ohno Seiko
- Journal Title
  
  Journal of Cardiology
  
  Volume: 18 Issue: 1 Pages: 30012-1
- DOI
  10.1016/j.jjcc.2017.12.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09499, KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-15K09689, KAKENHI-PROJECT-17K09494, KAKENHI-PROJECT-18K07875
[Journal Article] A hERG mutation E1039X produced a synergistic lesion on IKs together with KCNQ1-R174C mutation in a LQTS family with three compound mutations2018
- Author(s)
  Wu Jie、Mizusawa Yuka、Ohno Seiko、Ding Wei-Guang、Higaki Takashi、Wang Qi、Kohjitani Hirohiko、Makiyama Takeru、Itoh Hideki、Toyoda Futoshi、James Andrew F.、Hancox Jules C.、Matsuura Hiroshi、Horie Minoru
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 3129-3129
- DOI
  10.1038/s41598-018-21442-6
- NAID
  120006529715
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09499, KAKENHI-PROJECT-17K08536, KAKENHI-PROJECT-17K09494, KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-15K09689, KAKENHI-PROJECT-18K07875
[Journal Article] Complex aberrant splicing in the induced pluripotent stem cell?derived cardiomyocytes from a patient with long QT syndrome carrying KCNQ1-A344Aspl mutation2018
- Author(s)
  Wuriyanghai Yimin、Makiyama Takeru、Sasaki Kenichi、Kamakura Tsukasa、Yamamoto Yuta、Hayano Mamoru、Harita Takeshi、Nishiuchi Suguru、Chen Jiarong、Kohjitani Hirohiko、Hirose Sayako、Yokoi Fumika、Gao Jingshan、Chonabayashi Kazuhisa、Watanabe Ken、Ohno Seiko、Yoshida Yoshinori、Kimura Takeshi、Horie Minoru
- Journal Title
  
  Heart Rhythm
  
  Volume: 15 Issue: 10 Pages: 1566-1574
- DOI
  10.1016/j.hrthm.2018.05.028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-18K07875, KAKENHI-PROJECT-18K15847, KAKENHI-PROJECT-16K09499, KAKENHI-PROJECT-17H04176, KAKENHI-PROJECT-18H02808
[Journal Article] Clinical Manifestations and Long-Term Mortality in Lamin A/C Mutation Carriers From a Japanese Multicenter Registry2018
- Author(s)
 14.Nakajima K, Aiba T, Makiyama T, Nishiuchi S, Ohno S, Kato K, Yamamoto Y, Doi T, Shizuta S, Onoue K, Yagihara N, Ishikawa T, Watanabe I, Kawakami H, Oginosawa Y, Murakoshi N, Nogami A, Aonuma K, Saito Y, Kimura T, Yasuda S, Makita N, Shimizu W, Horie M, Kusano K.
- Journal Title
 
 Circ J
 
 Volume: 82 Issue: 11 Pages: 2707-2714
- DOI
 10.1253/circj.CJ-18-0339
- NAID
 40021697176
- ISSN
 1346-9843, 1347-4820
- Year and Date
 2018-10-25
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-18K07875, KAKENHI-PROJECT-18K19550, KAKENHI-PROJECT-18K15847, KAKENHI-PROJECT-18KK0245, KAKENHI-PROJECT-16K09499, KAKENHI-PROJECT-15H04823, KAKENHI-PROJECT-18H02808, KAKENHI-PROJECT-18K15894
[Journal Article] Novel intracellular transport-refractory mutations in KCNH2 identified in patients with symptomatic long QT syndrome2018
- Author(s)
  Fukumoto Daisuke、Ding Wei-Guang、Wada Yuko、Fujii Yusuke、Ichikawa Mari、Takayama Koichiro、Fukuyama Megumi、Kato Koichi、Itoh Hideki、Makiyama Takeru、Omatsu-Kanbe Mariko、Matsuura Hiroshi、Horie Minoru、Ohno Seiko
- Journal Title
  
  Journal of Cardiology
  
  Volume: 71 Issue: 4 Pages: 401-408
- DOI
  10.1016/j.jjcc.2017.10.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08536, KAKENHI-PROJECT-17K09494, KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-15K09689, KAKENHI-PROJECT-18K07875, KAKENHI-PROJECT-17K15999
[Journal Article] Genotype-phenotype correlation of SCN5A mutation for clinical and electrocardiographic characteristics of probands with Brugada syndrome: Japanese Multicenter Registry.2017
- Author(s)
  Yamagata K, Horie M, et al.
- Journal Title
  
  Circulation
  
  Volume: 印刷中 Issue: 23 Pages: 0-0
- DOI
  10.1161/circulationaha.117.027983
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-26461130, KAKENHI-PROJECT-15K09150, KAKENHI-PROJECT-15K15311, KAKENHI-PROJECT-16K09499, KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-15KK0302, KAKENHI-PROJECT-15H04823, KAKENHI-PROJECT-15K09082, KAKENHI-PROJECT-15K09689
[Journal Article] Gene-Based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers.2017
- Author(s)
  Nishiuchi S, Makiyama T, Aiba T, Nakajima K, Hirose S, Kohjitani H, Yamamoto Y, Harita T, Hayano M, Wuriyanghai Y, Chen J, Sasaki K, Yagihara N, Ishikawa T, Onoue K, Murakoshi N, Watanabe I, Ohkubo K, Watanabe H, Ohno S, Doi T, Shizuta S, Minamino T, et.al
- Journal Title
  
  Circ Cardiovasc Genet.
  
  Volume: 6 Issue: 6
- DOI
  10.1161/circgenetics.116.001603
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09421, KAKENHI-PROJECT-16K09499, KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-15H04823, KAKENHI-PLANNED-26115008, KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-17H06806, KAKENHI-PROJECT-15K09150, KAKENHI-PROJECT-15K09689, KAKENHI-PROJECT-15K15311
[Journal Article] Cardiac conduction defects and brugada syndrome: A Family with overlap syndrome carrying a nonsense SCN5A mutation.2017
- Author(s)
  Aoki H, Nakamura T, Horie M, Ohno S, Makiyama T, Takemura T
- Journal Title
  
  Journal of Arrhythmia
  
  Volume: 33 Issue: 1 Pages: 35-39
- DOI
  10.1016/j.joa.2016.05.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Journal Article] Contribution of a KCNH2 variant in genotyped long QT syndrome: Romano-Ward syndrome under double mutations and acquired long QT syndrome under heterozygote.2017
- Author(s)
  Fujii Y, Horie M, et al.
- Journal Title
  
  J Cardiol
  
  Volume: 印刷中 Issue: 1 Pages: 74-79
- DOI
  10.1016/j.jjcc.2016.09.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-26461068, KAKENHI-PROJECT-16K09499, KAKENHI-PROJECT-17K08536, KAKENHI-PROJECT-17K09494, KAKENHI-PROJECT-17K09495
[Journal Article] Allele-specific Ablation Rescues Electrophysiological Abnormalities in a Human iPS Cell Model of Long-QT Syndrome with a CALM2 Mutation.2017
- Author(s)
  Yamamoto Y, Horie M, et al.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 印刷中 Issue: 9 Pages: 1670-1677
- DOI
  10.1093/hmg/ddx073
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-16K09499, KAKENHI-PROJECT-15K15311, KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-15H04823, KAKENHI-PROJECT-16H05297
[Journal Article] Development of a Patient-Derived Induced Pluripotent Stem Cell Model for the Investigation of SCN5A-D1275N-Related Cardiac Sodium Channelopathy2017
- Author(s)
 Hayano M, Makiyama T
- Journal Title
 
 Circ J
 
 Volume: 81 Issue: 12 Pages: 1783-1791
- DOI
 10.1253/circj.CJ-17-0064
- NAID
 130006219109
- ISSN
 1346-9843, 1347-4820
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-16K09499, KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-17K09860, KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-17H04177, KAKENHI-PROJECT-17H06806
[Journal Article] LMNA cardiomyopathy detected in Japanese arrhythmogenic right ventricular cardiomyopathy cohort.2016
- Author(s)
  Kato K, Takahashi N, Fujii Y, Umehara A, Nishiuchi S, Makiyama T, Ohno S, Horie M
- Journal Title
  
  J Cardiol
  
  Volume: 印刷中 Issue: 4 Pages: 346-51
- DOI
  10.1016/j.jjcc.2015.10.013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15311, KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-15H04823, KAKENHI-PROJECT-25461054, KAKENHI-PROJECT-16K09499
[Journal Article] The genetics underlying acquired long QT syndrome: impact for genetic screening.2016
- Author(s)
  Itoh H, Crotti L, Aiba T, Spazzolini C, Denjoy I, Fressart V, Hayashi K, Nakajima T, Ohno S, Makiyama T, Wu J, Hasegawa K, Mastantuono E, Dagradi F, Pedrazzini M, Yamagishi M, Berthet M, Murakami Y, Shimizu W, Guicheney P, Schwartz PJ, Horie M.
- Journal Title
  
  European Heart Journal
  
  Volume: 37 (18) Issue: 18 Pages: 1456-1464
- DOI
  10.1093/eurheartj/ehv695
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09150, KAKENHI-PROJECT-15K09689, KAKENHI-PROJECT-25460406, KAKENHI-PROJECT-15K15311, KAKENHI-PUBLICLY-25136727, KAKENHI-PROJECT-15H04823, KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-26461056, KAKENHI-PROJECT-16K09499, KAKENHI-PROJECT-15KK0302
[Journal Article] Cardiac sodium channel mutation associated with epinephrine-induced QT prolongation and sinus node dysfunction.2016
- Author(s)
  Chen J, Makiyama T, Wuriyanghai Y, Ohno S, Sasaki K, Hayano M, Harita T, Nishiuchi S, Yamamoto Y, Ueyama T, Shimizu A, Horie M, Kimura T.
- Journal Title
  
  Heart Rhythm
  
  Volume: 13(1) Issue: 1 Pages: 289-298
- DOI
  10.1016/j.hrthm.2015.08.021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461068, KAKENHI-PROJECT-15K15311, KAKENHI-PROJECT-15H04823, KAKENHI-PROJECT-25461054, KAKENHI-PROJECT-15H04818
[Journal Article] Cardiac Sodium Channel Mutation Associated with Epinephrine-Induced QT Prolongation and Sinus Node Dysfunction.2016
- Author(s)
  Chen J, Makiyama T, Wuriyanghai Y, Ohno S, Sasaki K, Hayano M, Harita T, Nishiuchi S, Yamamoto Y, Ueyama T, Shimizu A, Horie M, Kimura T.
- Journal Title
  
  Heart Rhythm.
  
  Volume: 13 Pages: 289-298
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Journal Article] A novel SCN5A variant associate with drug-induced Brugada Syndrome2016
- Author(s)
  Turker I, Horie M, et al.
- Journal Title
  
  Plos ONE
  
  Volume: 11 Issue: 8 Pages: e0161872-e0161872
- DOI
  10.1371/journal.pone.0161872
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-25460406, KAKENHI-PROJECT-16K09499
[Journal Article] Novel SCN10A variants associated with Brugada syndrome2016
- Author(s)
  Fukuyama M, Ohno S, Makiyama T, Horie M
- Journal Title
  
  Europace.
  
  Volume: 印刷中 Issue: 3 Pages: 520-529
- DOI
  10.1093/cvr/cvv042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15311, KAKENHI-PROJECT-15H04823
[Journal Article] Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia2016
- Author(s)
  Sasaki K, Makiyama T, Yoshida Y, Wuriyanghai Y, Kamakura T, Nishiuchi S, Hayano M, Harita T, Yamamoto Y, Kohjitani H, Hirose S, Chen J, Kawamura M, Ohno S, Itoh H, Takeuchi A, Matsuoka S, Miura M, Sumitomo N, Horie M, Yamanaka S, Kimura T
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 10 Pages: e0164795-e0164795
- DOI
  10.1371/journal.pone.0164795
- NAID
  120005860036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04674, KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-26291019, KAKENHI-PROJECT-25460406, KAKENHI-PROJECT-15K09689, KAKENHI-PROJECT-16K09499
[Journal Article] The Genetics Underlying Acquired Long QT Syndrome. Impact on Management.2015
- Author(s)
  Itoh H, Crotti L, Aiba T, Spazzplini C, Denjoy I, Fressart V, Hayashi K, Nakajima T, Ohno S, Makiyama T, Wu J, Hasegawa K, Mastantuono E, Dagradi F, Pedrazzini M, Yamagishi M, Berthet M, Murakami Y, Shimizu W, Guicheney P, Schwartz PJ, Horie M.
- Journal Title
  
  European Heart Journal
  
  Volume: 28
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Journal Article] The genetics underlying acquired long QT syndrome: impact for genetic screening2015
- Author(s)
  Itoh H, Crotti L, Aiba T, Spazzolini C, Denjoy I, Fressart V, Hayashi K, Nakajima T, Ohno S, Makiyama T, Wu J, Hasegawa K, Mastantuono E, Dagradi F, Pedrazzini M, Yamagishi M, Berthet M, Murakami Y, Shimizu W, Guicheney P, Schwartz PJ, Horie M
- Journal Title
  
  Eur Heart J
  
  Volume: -
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461054
[Journal Article] Clinical Impact of Left Ventricular Outflow Tract Obstruction in Takotsubo Cardiomyopathy2015
- Author(s)
  Kawaji T, Shiomi H, Morimoto T, Tazaki J, Imai M, Saito N, Makiyama T, Shizuta S, Ono K, Kimura T.
- Journal Title
  
  Circ J
  
  Volume: 79 Issue: 4 Pages: 839-846
- DOI
  10.1253/circj.CJ-14-1148
- NAID
  130005130261
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790754, KAKENHI-PROJECT-25293182, KAKENHI-PROJECT-25670383, KAKENHI-PUBLICLY-26116716, KAKENHI-PROJECT-26293186
[Journal Article] Novel SCN10A Variants Associated with Brugada Syndrome.2015
- Author(s)
  Fukuyama M, Ohno S, Makiyama T, Horie M.
- Journal Title
  
  Europace
  
  Volume: 4
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Journal Article] Novel SCN10A variants associated with Brugada syndrome2015
- Author(s)
  Fukuyama M, Ohno S, Makiyama T, Horie M.
- Journal Title
  
  Europace
  
  Volume: 0 Issue: 6 Pages: 0-0
- DOI
  10.1093/europace/euv078
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591575, KAKENHI-PROJECT-15K19375, KAKENHI-PROJECT-15H04818
[Journal Article] Asymmetry of parental origin in Long QT syndrome. Preferential maternal transmission of KCNQ1 variants linked to channel dysfunction.2015
- Author(s)
  Itoh H, Berthet M, Fressart V, Denjoy I, Maugenre S, Klug D, Mizusawa Y, Makiyama T, Hofman N, Shimizu W, Wilde AAM, Schulze-Bahr E, Horie M, Tezenas du Montcel S, Guicheney P.
- Journal Title
  
  European Journal of Human Genetics
  
  Volume: - Issue: 8 Pages: 1160-6
- DOI
  10.1038/ejhg.2015.257
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460406, KAKENHI-PROJECT-15K15311, KAKENHI-PROJECT-15H04818, KAKENHI-PROJECT-15H04823, KAKENHI-PROJECT-25461054
[Journal Article] Significance of electrocardiogram recording in high intercostal spaces in patients with early repolarization syndrome2015
- Author(s)
  Kamakura T, Wada M, Nakajima I, Ishibashi K, Miyamoto K, Okamura H, Noda T, Aiba T, Takaki H, Yasuda S, Ogawa H, Shimizu W, Makiyama T, Kimura T, Kamakura S, Kusano K
- Journal Title
  
  Eur Heart J
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461054
[Journal Article] Mosaic KCNJ2 mutation in Andersen-Tawil syndrome: targeted deep sequencing is useful for the detection of mosaicism.2015
- Author(s)
  Hasegawa K, Ohno S, Kimura H, Itoh H, Makiyama T, Yoshida Y, Horie M.
- Journal Title
  
  Clin Genet
  
  Volume: 87 Issue: 3 Pages: 279-83
- DOI
  10.1111/cge.12357
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25136705, KAKENHI-PROJECT-25460406, KAKENHI-PROJECT-26461068, KAKENHI-PROJECT-15H04818
[Journal Article] Novel SCN10A variants associated with Brugada syndrome2015
- Author(s)
  Fukuyama M, Ohno S, Makiyama T, Horie M
- Journal Title
  
  Europace
  
  Volume: -
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461054
[Journal Article] Anticoagulant and Antiplatelet Therapy in Patients with Atrial Fibrillation Undergoing Percutaneous Coronary Intervention2014
- Author(s)
  Goto K, Nakai K, Shizuta S, Morimoto T, Shiomi H, Natsuaki M, Tahata M, Ota C, Ono K, Makiyama T, Nakagawa Y, Furukawa Y, et al.
- Journal Title
  
  Am J Cardiol
  
  Volume: 114 Issue: 1 Pages: 70-78
- DOI
  10.1016/j.amjcard.2014.03.060
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24531210, KAKENHI-PROJECT-25293182, KAKENHI-PROJECT-25670383, KAKENHI-PROJECT-26293186
[Journal Article] A novel KCNQ1 missense mutation identified in a patient with juvenile-onset atrial fibrillation causes constitutively open IKs channels.2014
- Author(s)
  Hasegawa K, Ohno S, Ashihara T, Itoh H, Ding WG, Toyoda F, Makiyama T, Aoki H, Nakamura Y, Delisle BP, Matsuura H, Horie M.
- Journal Title
  
  Heart Rhythm
  
  Volume: 11 Issue: 1 Pages: 67-75
- DOI
  10.1016/j.hrthm.2013.09.073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590258, KAKENHI-PROJECT-24591575, KAKENHI-PUBLICLY-25136705, KAKENHI-PROJECT-25460287, KAKENHI-PROJECT-25460406, KAKENHI-PROJECT-25461054, KAKENHI-PROJECT-25461106
[Journal Article] Effect of Pre-infarction Angina Pectoris on Long-term Survival in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention2014
- Author(s)
  Taniguchi T, Shiomi H, Toyota T, Morimoto T, Akao M, Nakatsuma K, Ono K, Makiyama T, Shizuta S, Furukawa Y, Nakagawa Y, Ando K, Kadota K, Horie M, Kimura T.
- Journal Title
  
  Am J Cardiol
  
  Volume: 114 Issue: 8 Pages: 1179-1186
- DOI
  10.1016/j.amjcard.2014.07.038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24531210, KAKENHI-PROJECT-25293182, KAKENHI-PROJECT-25670383, KAKENHI-PUBLICLY-26116716, KAKENHI-PROJECT-26293186
[Journal Article] Brugada syndrome in spinal and bulbar muscular atrophy.2014
- Author(s)
  Araki A, Katsuno M, Suzuki K, Banno H, Suga N, Hashizume A, Mano T, Hijikata Y, Nakatsuji H, Watanabe H, Yamamoto M, Makiyama T, Ohno S, Fukuyama M, Morimoto S, Horie M, Sobue G
- Journal Title
  
  Neurology
  
  Volume: 82 Issue: 20 Pages: 1813-1821
- DOI
  10.1212/wnl.0000000000000434
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22110005, KAKENHI-PROJECT-24659428, KAKENHI-PROJECT-25461054, KAKENHI-ORGANIZER-26117001, KAKENHI-PROJECT-26293206, KAKENHI-PROJECT-26670440, KAKENHI-PLANNED-26117002
[Journal Article] Long QT Syndrome Type8: Novel CACNA1C Mutations Causing QT Prolongation and Variant Phenotypes.2014
- Author(s)
  Fukuyama M, Wang Q, Kato K, Ohno S, Ding WG, Toyoda F, Itoh H, Kimura H, Makiyama T, Ito M, Matsuura H, Horie M.
- Journal Title
  
  Europace.
  
  Volume: in press Issue: 12 Pages: 1828-37
- DOI
  10.1093/europace/euu063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591575, KAKENHI-PUBLICLY-25136705, KAKENHI-PROJECT-25460287, KAKENHI-PROJECT-25460406, KAKENHI-PROJECT-25461054, KAKENHI-PROJECT-26460295
[Journal Article] Cardiac channelopathies associated with infantile fatal ventricular arrhythmias: from the cradle to the bench.2014
- Author(s)
  Kato K, Makiyama T, Wu J, Ding WG, Kimura H, Naiki N, Ohno S, Itoh H, Nakanishi T, Matsuura H, Horie M.
- Journal Title
  
  J Cardiovasc Electrophysiol
  
  Volume: 25 Issue: 1 Pages: 66-73
- DOI
  10.1111/jce.12270
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25136705, KAKENHI-PROJECT-25460287, KAKENHI-PROJECT-25460406, KAKENHI-PROJECT-25461054
[Journal Article] Long-term efficacy and safety outcomes after unrestricted use of drug-eluting stents in patients with acute coronary syndrome: mortality and major bleeding in a single-center registry.2014
- Author(s)
  Kawaji T, Shiomi H, Morimoto T, Tamura T, Nishikawa R, Yano M, Tazaki J, Imai M, Saito N, Makiyama T, Shizuta S, Ono K, Kimura T.
- Journal Title
  
  Circ J.
  
  Volume: 78 Pages: 1628-35
- NAID
  130004926956
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293182
[Journal Article] A novel HCN4 mutation, G1097W, is associated with atrioventricular block2014
- Author(s)
  Zhou J, Ding WG, Makiyama T, Miyamoto A, Matsumoto Y, Kimura H, Tarutani Y, Zhao J, Wu J, Zang WJ, Matsuura H, Horie M
- Journal Title
  
  Circ J
  
  Volume: 78 Pages: 938-942
- NAID
  130003391031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461054
[Journal Article] Gain-of-function KCNH2 mutations in patients with Brugada syndrome.2014
- Author(s)
  Wang Q, Ohno S, Ding WG, Fukuyama M, Miyamoto A, Itoh H, Makiyama T, Wu J, Bai J, Hasegawa K, Shinohara T, Takahashi N, Shimizu A, Matsuura H, Horie M.
- Journal Title
  
  J Cardiovasc Electrophysiol.
  
  Volume: 25 Issue: 5 Pages: 522533-522533
- DOI
  10.1111/jce.12361
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591575, KAKENHI-PUBLICLY-25136705, KAKENHI-PROJECT-25460287, KAKENHI-PROJECT-25460406, KAKENHI-PROJECT-25461054
[Journal Article] Sodium channelopathy underlying familial sick sinus syndrome with early onset and predominantly male characteristics.2014
- Author(s)
  Abe K, Machida T, Sumitomo N, Yamamoto H, Ohkubo K, Watanabe I, Makiyama T, Fukae S, Kohno M, Harrell DT, Ishikawa T, Tsuji Y, Nogami A, Watabe T, Oginosawa Y, Abe H, Maemura K, Motomura H, Makita N.
- Journal Title
  
  Circ Arrhythm Electrophysiol
  
  Volume: in press Issue: 3 Pages: 511-517
- DOI
  10.1161/circep.113.001340
- NAID
  120006986434
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22136007, KAKENHI-PROJECT-24390199, KAKENHI-PROJECT-25461054, KAKENHI-PROJECT-25461113, KAKENHI-PROJECT-26860572
[Journal Article] Novel SCN3B mutation associated with brugada syndrome affects intracellular trafficking and function of Nav1.52013
- Author(s)
  Ishikawa T, Takahashi N, Ohno S, Sakurada H, Nakamura K, On YK, Park JE, Makiyama T, Horie M, Arimura T, Makita N, Kimura A
- Journal Title
  
  Circ J
  
  Volume: 77 Pages: 959-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461054
[Journal Article] Long-Term Follow-Up of a Pediatric Cohort With Short QT Syndrome2013
- Author(s)
  Villafane J, Atallah J, Gollob MH, Maury P, Wolpert C, Gebauer R, Watanabe H, Horie M, Anttonen O, Kannankeril P, Faulknier B, Bleiz J, Makiyama T, Shimizu W, Hamilton R, Young ML.
- Journal Title
  
  J Am Coll Cardiol
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] A novel SCN5A mutation demonstrating a variety of clinical phenotypes in familial sick sinus syndrome2013
- Author(s)
  Nakajima S, Makiyama T, Hanazawa K, Kaitani K, Amano M, Hayama Y, Onishi N, Tamaki Y, Miyake M, Tamura T, Kondo H, Motooka M, Izumi C, Nakagawa Y, Horie M
- Journal Title
  
  Intern Med
  
  Volume: 52 Pages: 1805-8
- NAID
  130003365751
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461054
[Journal Article] L-type calcium channel mutations in Japanese patients with inherited arrhythmias2013
- Author(s)
  Fukuyama M, Ohno S, Wang Q, Kimura H, Makiyama T, Itoh H, Ito M, Horie M.
- Journal Title
  
  Circ J
  
  Volume: 77 Pages: 1799-806
- NAID
  10031173762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461054
[Journal Article] Ultrastructural Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Long-Term Culture2013
- Author(s)
  Kamakura T, Makiyama T, Sasaki K, Yoshida Y , Wuriyanghai Y, Chen J, Hattori T, Ohno S, Kita T, Horie M, Yamanaka S, Kimura T
- Journal Title
  
  Circ J
- NAID
  40020559020
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] Ultrastructural Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Long-Term Culture2013
- Author(s)
  Kamakura T, Makiyama T, Sasaki K, Yoshida Y, Wuriyanghai Y, Chen J, Hattori T, Ohno S, Kita T, Horie M, Yamanaka S, Kimura T
- Journal Title
  
  Circ J
- NAID
  10031151395
- Data Source
  KAKENHI-PROJECT-24659387
[Journal Article] Age-dependent clinical and genetic characteristics in Japanese patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia2013
- Author(s)
  Ohno S, Nagaoka I, Fukuyama M, Kimura H, Itoh H, Makiyama T, Shimizu A, Horie M
- Journal Title
  
  Circ J
  
  Volume: 77 Pages: 1534-42
- NAID
  10031158884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461054
[Journal Article] Ultrastructural maturation of human-induced pluripotent stem cell-derived cardiomyocytes in a long-term culture2013
- Author(s)
  Kamakura T, Makiyama T, Sasaki K, Yoshida Y, Wuriyanghai Y, Chen J, Hattori T, Ohno S, Kita T, Horie M, Yamanaka S, Kimura T.
- Journal Title
  
  Ｃｉｒｃ　Ｊ
  
  Volume: 77 Pages: 1307-14
- NAID
  40020559020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461054
[Journal Article] Genetic background of catecholaminergic polymorphic ventricular tachycardia in Japan2013
- Author(s)
  Kawamura M, Ohno S, Naiki N, Nagaoka I, Dochi K, Wang Q, Hasegawa K, Kimura H, Miyamoto A, Mizusawa Y, Itoh H, Makiyama T, Sumitomo N, Ushinohama H, Oyama K, Murakoshi N, Aonuma K, Horigome H, Honda T, Yoshinaga M, Ito M, Horie M
- Journal Title
  
  Circ J
  
  Volume: 77 Pages: 1705-13
- NAID
  10031173750
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461054
[Journal Article] Ultrastructural maturation of human-induced pluripotent stem cell-derived cardiomyocytes in a long-term culture.2013
- Author(s)
  Kamakura T, Makiyama T, Sasaki K, Yoshida Y, Wuriyanghai Y, Chen J, Hattori T, Ohno S, Kita T, Horie M, Yamanaka S, Kimura T.
- Journal Title
  
  Circ J.
  
  Volume: 77 Pages: 1307-14
- NAID
  10031151395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293182
[Journal Article] Long-Term Follow-Up of a Pediatric Cohort With Short QT Syndrome2013
- Author(s)
  Villafane J, Atallah J, Gollob MH, Maury P, Wolpert C, Gebauer R, Watanabe H, Horie M, Anttonen O, Kannankeril P, Faulknier B, Bleiz J, Makiyama T, Shimizu W, Hamilton R, Young ML
- Journal Title
  
  J Am Coll Cardiol
- Data Source
  KAKENHI-PROJECT-24659387
[Journal Article] Long Term Follow-up of a Pediatric Cohort with Short QT Syndrome.2013
- Author(s)
  Villafane J, Atallah J,Horie M, et al.
- Journal Title
  
  J Am Coll Cardiol.
  
  Volume: 61(11) Issue: 11 Pages: 1183-91
- DOI
  10.1016/j.jacc.2012.12.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390209, KAKENHI-PROJECT-24591038, KAKENHI-PROJECT-25293182, KAKENHI-PROJECT-25461054
[Journal Article] Clinical and electrocardiographic characteristics of patients with short QT interval in a large hospital-based population2012
- Author(s)
  Miyamoto A, Hayashi H, Yoshino T, Kawaguchi T, Taniguchi A, Itoh H, Sugimoto Y, Itoh M, Makiyama T, XueJQ, Murakami Y, Horie M
- Journal Title
  
  Heart Rhythm.
  
  Volume: 9(1) Pages: 66-74
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] Clinical characteristics and risk of arrhythmia recurrences in patients with idiopathic ventricular fibrillation associated with early repolarization.2012
- Author(s)
  Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe
- Journal Title
  
  Int J Cardiol
  
  Volume: 159(3) Pages: 238-40
- Data Source
  KAKENHI-PROJECT-24659387
[Journal Article] A connexin40 mutation associated with a malignant variant of progressive familial heart block type I.2012
- Author(s)
  Makita N, Seki A, Sumitomo N, Chkourko H, Fukuhara S, Watanabe H, Shimizu W, Bezzina CR, Hasdemir C, Mugishima H, Makiyama T, Baruteau A, Baron E, Horie M, Hagiwara N, Wilde AA, Probst V, Le Marec H, Roden DM, Mochizuki N, Schott JJ, Delmar M.
- Journal Title
  
  Circ Arrhythm Electrophysiol.
  
  Volume: 5(1) Pages: 163-72
- NAID
  120006985450
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] Phenotype variability in patients carrying KCNJ2 mutations2012
- Author(s)
  Kimura H, Zhou J, Kawamura M, Itoh H, Mizusawa Y, Ding WG, Wu J, Ohno S, Makiyama T, Miyamoto A, Naiki N, Wang Q, Xie Y, Suzuki T, Tateno S, Nakamura Y, Zang WJ, Ito M, Matsuura H, Horie M
- Journal Title
  
  Circ Cardiovasc Genet
  
  Volume: 5(3) Pages: 344-53
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] Novel SCN3B Mutation Associated With Brugada Syndrome Affects Intracellular Trafficking and Function of Nav1.52012
- Author(s)
  Ishikawa T, Takahashi N, Ohno S, Sakurada H, Nakamura K, On YK, Park JE, Makiyama T, Horie M, Arimura T, Makita N, Kimura A
- Journal Title
  
  Circ J
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] Phenotype variability in patients carrying KCNJ2 mutations.2012
- Author(s)
  Kimura H, Zhou J, Kawamura M, Itoh H, Mizusawa Y, Ding WG, Wu J, Ohno S, Makiyama T, Miyamoto A, Naiki N, Wang Q, Xie Y, Suzuki T, Tateno S, Nakamura Y, Zang WJ, Ito M, Matsuura H, Horie M
- Journal Title
  
  Circ Cardiovasc Genet.
  
  Volume: 5(3) Pages: 344-53
- Data Source
  KAKENHI-PROJECT-24659387
[Journal Article] Novel SCN3B Mutation Associated With Brugada Syndrome Affects Intracellular Trafficking and Function of Nav1.52012
- Author(s)
  Ishikawa T, Takahashi N, Ohno S, Sakurada H, Nakamura K, On YK, Park JE, Makiyama T, Horie M, Arimura T, Makita N, Kimura A
- Journal Title
  
  Circ J
- Data Source
  KAKENHI-PROJECT-24659387
[Journal Article] A novel gain-of-function KCNJ2 mutation associated with short-QT syndrome impairs inward rectification of Kir2.1 currents.2012
- Author(s)
  Hattori T, Makiyama T, Akao M, Ehara E, Ohno S, Iguchi M, Nishio Y, Sasaki K, Itoh H, Yokode M, Kita T, Horie M, Kimura T
- Journal Title
  
  Cardiovasc Res
  
  Volume: 93 Pages: 666-673
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] Clinical characteristics and risk of arrhythmia recurrences in patients with idiopathic ventricular fibrillation associated with early repolarization.2012
- Author(s)
  Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizaw
- Journal Title
  
  Int J Cardiol.
  
  Volume: 159(3) Pages: 238-40
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] A novel gain-of-function KCNJ2 mutation associated with short QT syndrome impairs inward rectification of Kir2.1 currents.2012
- Author(s)
  Hattori T, Makiyama T, Akao M, Ehara E, Ohno S, Iguchi M, Nishio Y, Sasaki K, Itoh H, Yokode M, Kita T, Horie M, Kimura T
- Journal Title
  
  Cardiovasc Res
  
  Volume: 93(4) Pages: 666-73
- Data Source
  KAKENHI-PROJECT-24659387
[Journal Article] Clinical and electrocardiographic characteristics of patients with short QT interval in a large hospital-based population.2012
- Author(s)
  Miyamoto A, Hayashi H, Yoshino T, Kawaguchi T, Taniguchi A, Itoh H, Sugimoto Y, Itoh M, Makiyama T, Xue JQ, Murakami Y, Horie M
- Journal Title
  
  Heart Rhythm
  
  Volume: 9 Pages: 66-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] A novel gain-of-function KCNJ2 mutation associated with short-QT syndrome impairs inward rectification of Kir2.1currents2012
- Author(s)
  Hattori T, Makiyama T, Akao M, Ehara E, Ohno S, Iguchi M, Nishio Y, Sasaki K, Itoh H, Yokode M, Kita T, Horie M, Kimura T.
- Journal Title
  
  Cardiovasc Res
  
  Volume: 93(4) Pages: 666-73
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] A novel gain-of-function KCNJ2 mutation associated with short QT syndrome impairs inward rectification of Kir2.1 currents.2012
- Author(s)
  Hattori T, Makiyama T, Akao M, Ehara E, Ohno S, Iguchi M, Nishio Y, Sasaki K, Itoh H, Yokode M, Kita T, Horie M, Kimura T.
- Journal Title
  
  Cardiovasc Res
  
  Volume: 93(4) Pages: 666-73
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] Identification and functional characterization of KCNQ1 mutations around the exon 7-intron 7 junction affecting the splicing process2011
- Author(s)
  Tsuji-Wakisaka K, Akao M, Ishii TM, Ashihara T, Makiyama T, Ohno S, Toyoda F, Dochi K, Matsuura H, Horie M.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1812(11) Pages: 1452-9
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] A novel KCNJ2 nonsense mutation, S369X, impedes trafficking and causes a limited form of Andersen-Tawil syndrome2011
- Author(s)
  Doi T, Makiyama T, et al.
- Journal Title
  
  Circulation Cardiovascular Genetics
  
  Volume: (掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation2011
- Author(s)
  Ohno S, Zankov D, Ding W, MakiyamaT, Doi T, Shizuta S, Itoh H, Nishio Y, Hattori T, Matsuura H, Horie M.
- Journal Title
  
  Circ Arrhythm Electrophysiol.
  
  Volume: 4(3) Pages: 352-61
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] 循環器疾患の発症機序解明におけるiPS細胞の可能性2011
- Author(s)
  牧山武
- Journal Title
  
  循環器内科
  
  Volume: 70 Pages: 530-536
- NAID
  40019123504
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] A novel KCM2 nonsense mutation, S369X, impedes trafficking and causes a limited form of Andersen-Tawil Syndrome.2011
- Author(s)
  Doi T, Makiyama T, Morimoto T, Haruna Y, Tsuji K, Akao M, Takahashi Y, Kimura T, Horie M.
- Journal Title
  
  Circulation Cardiovascular Genetics.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] KCNE5 (KCNE1L) variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrillation.2011
- Author(s)
  Ohno S, Zankov D, Ding W, Makiyama T, Doi T, Shizuta S, Itoh H, Nishio Y, Hattori T, Matsuura H, Horie M
- Journal Title
  
  Circ Arrhythm Electrophysiol
  
  Volume: 4 Pages: 352-361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] Risk Determinants in Individuals With a Spontaneous Type 1 Brugada ECG.2011
- Author(s)
  Miyamoto A, Hayashi H, Makiyama T, Yoshino T, Mizusawa Y, Sugimoto Y, Ito M, Xue JQ, Murakami Y, Horie M.
- Journal Title
  
  Circ J. 75(4)
  
  Pages: 1623-9
- NAID
  10028103115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] Risk Determinants in Individuals With a Spontaneous Type 1 Brugada ECG2011
- Author(s)
  Miyamoto S, Makiyama T, et al.
- Journal Title
  
  Circulation Journal
  
  Volume: (掲載確定)
- NAID
  10028103115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] A novel KCNJ2 nonsense mutation, S369X, impedes trafficking and causes a limited form of Andersen-Tawil syndrome.2011
- Author(s)
  Tsuji-Wakisaka K, Akao M, Ishii TM, Ashihara T, Makiyama T, Ohno S, Toyoda F, Dochi K, Matsuura H, Horie M
- Journal Title
  
  Circ Cardiovasc Genet
  
  Volume: 1812 Pages: 1452-1459
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] 循環器疾患の発症機序解明における iPS 細胞の可能性2011
- Author(s)
  牧山武
- Journal Title
  
  循環器内科
  
  Volume: 70(5) Pages: 530-536
- NAID
  40019123504
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization.2011
- Author(s)
  Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, Makiyama T, Nagao S, Yagihara N, Takehara N, Kawamura Y, Sato A, Okamura K, Hosaka Y, Sato M, Fukae S, Chinushi M, Oda H, Okabe M, Kimura A, Maemura K, Watanabe I, Kamakura S, Horie M, Aizaw
- Journal Title
  
  Circ Arrhythm Electrophysiol.
  
  Volume: 4(6) Pages: 874-81
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] novel KCNJ2 nonsense mutation, S369X, impedes trafficking and causes a limited form of Andersen-Tawil syndrome.2011
- Author(s)
  Doi T, Makiyama T, Morimoto T, Haruna Y, Tsuji K, Ohno S, Akao M, Takahashi Y, Kimura T, Horie M
- Journal Title
  
  Circ Cardiovasc Genet
  
  Volume: 4 Pages: 253-260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] Novel KCNE5 variants are associated with Brugada syndrome and idiopathic ventricular fibrillation.2011
- Author(s)
  Ohno S, Zankov D, Ding W, Makiyama T, Doi T, Shizuta S, Itoh H, Nishio Y, Hattori T, Matsuura H, Horie M.
- Journal Title
  
  Circulation Arrhythmia and Electrophysiol.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] Novel KCNE5 variants are associated with Brugada syndrome and idiopathic ventricular fibrillation2011
- Author(s)
  Ohno S, Makiyama T, et al.
- Journal Title
  
  Circulation Arrhythmia and Electrophysiology
  
  Volume: (掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] A novel KCNJ2 nonsense mutation, S369X, impedes trafficking and causes a limited form of Andersen-Tawil syndrome.2011
- Author(s)
  DoiT,MakiyamaT,MorimotoT,HarunaY,TsujiK,OhnoS,AkaoM,TakahashiY,KimuraT,HorieM
- Journal Title
  
  Circ Cardiovasc Genet.
  
  Volume: 4(3) Pages: 253-60
- Data Source
  KAKENHI-PROJECT-23790848
[Journal Article] Atrioventricular block-induced Torsades de Pointes with clinical and molecular backgrounds similar to congenital long QT syndrome.2010
- Author(s)
  Oka Y, Itoh H, Ding WG, Shimizu W, Makiyama T, Ohno S, Nishio Y, Sakaguchi T, Miyamoto A, Kawamura M, Matsuura H, Horie M.
- Journal Title
  
  Circ J. 25;74(12)
  
  Pages: 2562-71
- NAID
  10027424141
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] 家族性ベースメーカ植込み症例における遺伝的背景の検討-心臓Na+チャネル病、Lamin A/C遺伝子関連心筋症-2010
- Author(s)
  牧山武, 静田聡, 赤尾昌治, 木村剛, 堀江稔
- Journal Title
  
  心電図
  
  Volume: 30 Pages: 201-209
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] A novel SCN5A mutation associated with the linker between III and IV domains of Na (v) 1.5 in a neonate with fatal long QT syndrome.2010
- Author(s)
  Yamamura K, Muneuchi J, Uike K, Ikeda K, Inoue H, Takahata Y, Shiokawa Y, Yoshikane Y, Makiyama T, Horie M, Hara T.
- Journal Title
  
  Int J Cardiol. 5;145(1)
  
  Pages: 61-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] High prevalence of early repolarization in short QT syndrome.2010
- Author(s)
  Watanabe H, Makiyama T, Koyama T, Kannankeril PJ, Seto S, Okamura K, Oda H, Itoh H, Okada M, Tanabe N, Yagihara N, Kamakura S, Horie M, Aizawa Y, Shimizu W.
- Journal Title
  
  Heart Rhythm. 7(5)
  
  Pages: 647-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] 堀江稔家族性ベースメーカ植込み症例における遺伝的背景の検討-心臓Na+チャネル病2010
- Author(s)
  牧山武, 静田聡, 赤尾昌治, 木村剛
- Journal Title
  
  Lamin A/C遺伝子関連心筋症-心電図 30
  
  Pages: 201-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] High prevalence of early repolarization in short QT syndrome.2010
- Author(s)
  Watanabe H, Makiyama T, et al.
- Journal Title
  
  Heart Rhythm
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] Heart rate-dependent variability of cardiac events in type 2 congenital long-QT syndrome.2010
- Author(s)
  Nagaoka I, Shimizu W, Mizusawa Y, Sakaguchi T, Itoh H, Ohno S, Makiyama T, Yamagata K, Makimoto H, Miyamoto Y, Kamakura S, Horie M.
- Journal Title
  
  Europace. 12(11)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] Long QT syndrome with compound mutations is associated with a more severe phenotype : a Japanese multicenter study.2010
- Author(s)
  Itoh H, Shimizu W, Hayashi K, Yamagata K, Sakaguchi T, Ohno S, Makiyama T, Akao M, Ai T, Noda T, Miyazaki A, Miyamoto Y, Yamagishi M, Kamakura S, Horie M.
- Journal Title
  
  Heart Rhythm. 7(10)
  
  Pages: 1411-1418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] High prevalence of early repolarization in short QT syndrome2010
- Author(s)
  Watanabe H, Makiyama T, et al
- Journal Title
  
  Heart Rhythm
  
  Volume: 7 Pages: 647-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] Long QT syndrome with compound mutations is associated with a more severe phenotype : a Japanese multicenter study2010
- Author(s)
  Itoh H, Makiyama T, et al.
- Journal Title
  
  Heart Rhythm
  
  Volume: 7 Pages: 1411-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome.2009
- Author(s)
  Ohno S, Makiyama T, et al.
- Journal Title
  
  Human Mutation 30
  
  Pages: 557-563
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] D85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome.2009
- Author(s)
  Nishio Y, Makiyama T, et al.
- Journal Title
  
  The American College of Cardiology 54
  
  Pages: 812-819
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] A novel SCN5A mutation associated with the linker between III and IV domains of Na(v)1.5 in a neonate with fatal long QT syndrome.2009
- Author(s)
  Yamamura K, Makiyama T, et al.
- Journal Title
  
  International Jurnal of Cardiology
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] Latent genetic backgrounds and molecular pathogenesis in drug-induced long-QT syndrome.2009
- Author(s)
  Itoh H, Sakaguchi T, Ding WG, Watanabe E, Watanabe I, Nishio Y, Makiyama T, Ohno S, Akao M, Higashi Y, Zenda N, Kubota T, Mori C, Okajima K, Haruna T, Miyamoto A, Kawamura M, Ishida K, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Sugimoto Y, Ashihara T, Hayashi H, Ito M, Imoto K, Matsuura H, Horie M.
- Journal Title
  
  Circ Arrhythm Electrophysiol. 2(5)
  
  Pages: 511-523
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome.2009
- Author(s)
  Ohno S, Toyoda F, Zankov DP, Yoshida H, Makiyama T, Tsuji K, Honda T, Obayashi K, Ueyama H, Shimizu W, Miyamoto Y, Kamakura S, Matsuura H, Kita T, Horie M.
- Journal Title
  
  Hum Mutat. 30(4)
  
  Pages: 557-563
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] Latent genetic backgrounds and molecular pathogenesis in drug-induced long-QT syndrome.2009
- Author(s)
  Itoh H, Makiyama T, et al.
- Journal Title
  
  Circulation Arrhythmia Electrophysiology 2
  
  Pages: 511-523
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Journal Article] D85N, a KCNE1 polymorphism, is a disease-causing gene variant inlong QT syndrome.2009
- Author(s)
  Nishio Y, Makiyama T, Itoh H, Sakaguchi T, Ohno S, Gong YZ, Yamamoto S, Ozawa T, Ding WG, Toyoda F, Kawamura M, Akao M, Matsuura H, Kimura T, Kita T, Horie M.
- Journal Title
  
  J Am Coll Cardiol. 25;54(9)
  
  Pages: 812-819
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790720
[Patent] アンチセンスオリゴヌクレオチド医薬のスクリーニング方法2020
- Inventor(s)
  牧山武、山本雄大、入山友輔、近藤嘉紀、日高夕貴、石川龍太郎
- Industrial Property Rights Holder
  牧山武、山本雄大、入山友輔、近藤嘉紀、日高夕貴、石川龍太郎
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-036716
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K08538
[Patent] ＣＡＬＭ２のアンチセンスオリゴヌクレオチド2020
- Inventor(s)
  入山友輔、近藤嘉紀、日高夕貴、石川龍太郎、牧山武、山本雄大
- Industrial Property Rights Holder
  入山友輔、近藤嘉紀、日高夕貴、石川龍太郎、牧山武、山本雄大
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-036715
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K08538
[Patent] 医薬組成物2016
- Inventor(s)
  堀江稔、牧山武、松浦博、豊田太、張田健志
- Industrial Property Rights Holder
  堀江稔、牧山武、松浦博、豊田太、張田健志
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-250087
- Filing Date
  2016-12-22
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] iPSC Models of Inherited Arrhythmias2024
- Author(s)
  Takeru Makiyama
- Organizer
  第88回日本循環器学会学術集会（JCS2024）
- Invited
- Data Source
  KAKENHI-PROJECT-23K07575
[Presentation] Cellular and subcellular mechanisms of cardiac arrhythmia Disrupted CaV1.2 selectivity causes overlapping long QT and Brugada syndrome phenotypes in tips cell model ―iPS cell-based model for the study of inherited arrhythmias―2023
- Author(s)
  Takeru Makiyama
- Organizer
  16th Asia Pacific Heart Rhythm Society (APHRS) Scientific Session
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07575
[Presentation] Modeling familial sinus node dysfunction with a large intergenic deletion between PITX2 and ANK2 using iPS cell-derived sinoatrial nodal-like cardiomyocytes2023
- Author(s)
  T. Aizawa, T. Makiyama, H. Murata, T. Takaki, M. Baudic, J. Gao, T. Imamura, S. Ohno, Y. Yoshida, W. Shimizu, N. Makita, J. Barc, J.J. Schott, M. Horie, T. Kimura
- Organizer
  European Society of Cardiology Congress (ESC2023）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07575
[Presentation] Histological characteristics of a rat model of LMNA-related cardiomyopathy carrying an Lmna missense variant, p.S143P2023
- Author(s)
  Hai Huang, Takeru Makiyama, Manabu Shirai, Masaki Wakabayashi, Morikatsu Yoshida, Yasuaki Nakagawa, Koichiro Kuwahara, Osamu Yamaguchi, Naomasa Makita, Koh Ono.
- Organizer
  第7回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-23K07575
[Presentation] Non-cording deletions disrupt CTCF-mediated DNA loops flanking PITX2, causing a sinus node dysfunction: Novel molecular mechanism of inherited arrhythmias2023
- Author(s)
  村田広茂, Jean-Jacques Schott, 蒔田直昌, 牧山武, 大野　聖子, 清水渉
- Organizer
  第69回日本不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-22K08168
[Presentation] iPS細胞を用いた遺伝性不整脈の解析: iPS cell-based model for the study of inherited arrhythmias2023
- Author(s)
  牧山　武
- Organizer
  第8回日本心血管協会（JCVA）学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K07575
[Presentation] A Novel Calmodulin Mutation Associated with a Severe Form of Catecholaminergic Polymorphic Ventricular Tachycardia Causes Robust Arrhythmogenicity due to a Dominant Facilitative Effect on The Cardiac Ryanodine Receptors2023
- Author(s)
  Jingshan Gao, Takeru Makiyama, Yuta Yamamoto, Takuya Kobayashi, Hisaaki Aoki, Asami Kashiwa, Tomohiko Imamura, Takanori Aizawa, Hai Huang, Hirohiko Kohjitani, Koichi Kato, Futoshi Toyoda, Seiko Ohno, Nagomi Kurebayashi, Takashi Murayama, Minoru Horie, Takeshi Kimura.
- Organizer
  日本生理学会100周年記念大会
- Data Source
  KAKENHI-PROJECT-23K07575
[Presentation] ＜心電学サミット＞心電機能調節機構の正常と異常Basic mechanisms for cardiac electrical regulation and dysregulation: Modeling inherited arrhythmias using new iPS cell technology and applications in drug development2023
- Author(s)
  牧山　武
- Organizer
  第69回日本不整脈心電学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K07575
[Presentation] Clinical aspects of Brugada syndrome in children: the impact of gender and age on the prognosis2022
- Author(s)
  Tomohiko Imamura, Takeru Makiyama, Junichi Ozawa,Hai Huang, Takanori Aizawa, Jingshan Gao, Asami Kashiwa, Hirohiko Kohjitani, Koichi Kato, Hiroshi Suzuki, Keiko Sonoda, Seiko Ohno, Naokata Sumitomo, Minoru Horie, Takeshi Kimura
- Organizer
  第86回日本循環器学会学術集会（JCS2022）
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Modeling RYR2-related Long-QT Syndrome using iPS Cell Model Generated by CRISPR/Cas9-based Knock-in Genome Editing Technology2022
- Author(s)
  Jingshan Gao, Takeru Makiyama, Seiko Ohno, Yuta Yamamoto, Asami Kashiwa, Tomohiko Imamura, Takanori Aizawa, Hai Huang, Hirohiko Kohjitani, Minoru Horie, Takeshi Kimura
- Organizer
  第86回日本循環器学会学術集会（JCS2022）
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Calmodulinopathy is a common cause of critical cardiac phenotypes in2022
- Author(s)
  Fukuyama M, Horie M, Kato K, Ozawa T, Fujii Y, Okuyama Y, Makiyama T, Ohno S, Nakagawa Y.
- Organizer
  ESC Congress 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02888
[Presentation] Modeling Inherited Arrhythmias using Patient-derived iPS Cells. -Calmodulinopathy-2022
- Author(s)
  Takeru Makiyama
- Organizer
  第86回日本循環器学会学術集会（JCS2022）
- Invited
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] 乳幼児突然死症例における遺伝性不整脈の関与と死亡状況の検討2022
- Author(s)
  今村知彦，牧山武，大野聖子, 堀江稔
- Organizer
  第27回日本SIDS・乳幼児突然死予防学会
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Development of an Oligonucleotide-Based Therapeutic Approach for Calmodulinopathy2021
- Author(s)
  Makiyama T, Yamamoto Y, Kondoh Y, Gao J, Kashiwa A, Aizawa T, Imamura T, Huang H, Kohjitani H, Ishikawa T, Yoshida Y, Ohno S, Makita N, Horie M, Kimura T.
- Organizer
  第85回日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08416
[Presentation] Modeling Novel Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)-Associated Calmodulin Mutation CALM2-E46K using iPS cells2021
- Author(s)
  Jingshan Gao, Takeru Makiyama, Yuta Yamamoto, Asami Kashiwa, Takanori Aizawa, Tomohiko Imamura, Hai Huang, Hirohiko Kohjitani, Kouichi Kato, Seiko Ohno, Minoru Horie, Takeshi Kimura
- Organizer
  第5回日本循環器学会基礎研究フォーラム（BCVR2021）
- Invited
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Development of an Oligonucleotide-Based Therapeutic Approach for Calmodulinopathy2021
- Author(s)
  Takeru Makiyama, Yuta Yamamoto, Yoshiki Kondo, Jingshan Gao, Asami Kashiwa, Takanori Aizawa, Tomohiko Imamura, Hai Huang, Hirohiko Kohjitani, Taisuke Ishikawa, Yoshinori Yoshida, Seiko Ohno, Naomasa Makita, Minoru Horie, Takeshi Kimura
- Organizer
  第85回日本循環器学会学術集会（JCS2021）
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Inhibition of Late Sodium Current Shortens Action Potential Durations in CACNA1C-E1115K iPS Cell Model with Disrupted Cav1.2 Ion Selectivity2021
- Author(s)
  Asami Kashiwa, Takeru Makiyama, Hirohiko Kohjitani, Thomas Maurissen, Yimin Wuriyanghai, Yuta Yamamoto, Jingshan Gao, Hai Huang, Tomohiko Imamura, Takanori Aizawa, Taisuke Ishikawa, Seiko Ohno, Futoshi Toyoda, Seiich Sato, Kazuhiro Takahashi, Knut Woltjen, Minoru Horie, Naomasa Makita, Takeshi Kimura
- Organizer
  第67回日本不整脈心電学会学術集会（JHRS2021）
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Development of an Oligonucleotide-Based Therapeutic Approach for Calmodulinopathy2021
- Author(s)
  Makiyama T, Yamamoto Y, Ishikawa T, Makita N, Horie M, Kimura T et al.
- Organizer
  第85回日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Modeling Inherited Arrhythmias Associated with Ryanodine Receptor Dysfunction using iPS Cells2021
- Author(s)
  Makiyama T, Gao J, Yamamoto Y, Ishikawa T, Makita N, Kimura T et al.
- Organizer
  第85回日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Modeling Inherited Arrhythmias Associated with Ryanodine Receptor Dysfunction using iPS Cells2021
- Author(s)
  Makiyama T, Gao J, Yamamoto Y, Ishikawa T, Makita N, Kimura T et al.
- Organizer
  第85回日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08416
[Presentation] Modeling Inherited Arrhythmias Associated with Ryanodine Receptor Dysfunction using iPS Cells2021
- Author(s)
  Takeru Makiyama, Jingshan Gao, Yuta Yamamoto, Asami Kashiwa, Takanori Aizawa, Tomohiko Imamura, Hai Huang, Hirohiko Kohjitani, Kouichi Kato, Taisuke Ishikawa, Hisaaki, Aoki, Futoshi Toyoda, Knut Wolten, Yoshinori Yoshida, Seiko Ohno, Naomasa Makita, Minoru Horie, Takeshi Kimura
- Organizer
  第85回日本循環器学会学術集会（JCS2021）
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] 小児Brugada症候群の臨床的・遺伝学的特徴：年齢、性ホルモンの影響2021
- Author(s)
  今村知彦、牧山武、小澤淳一、加藤浩一、大野聖子、鈴木博、住友直方、堀江稔
- Organizer
  第25回小児心電学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] iPS細胞由来心筋細胞の電気生理学的特徴と遺伝性不整脈疾患モデルの検討2021
- Author(s)
  牧山武
- Organizer
  心電学関連春季大会2021
- Invited
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Preclinical Proof-of-Concept Study: Antisense-mediated Knockdown of CALM as a Therapeutic Strategy for Calmodulinopathy2020
- Author(s)
  Yamamoto Y, Makiyama T, Kondo Y, Iriyama Y, Ishikawa R, Kimura T et al.
- Organizer
  European Society of Cardiology Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Clinical and genetic aspects of pediatric Brugada syndrome2020
- Author(s)
  Tomohiko Imamura, Takeru Makiyama, Hai Huang, Takanori Aizawa, Jingshan Gao, Asami Kashiwa, Yimin Wuriyanghai, Yuta Yamamoto, Yasuhiko Kohjitani, Koichi Kato, Seiko Ohno, Naokata Sumitomo, Minoru Horie.
- Organizer
  European Society of Cardiology (ESC) Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] 患者由来iPS 細胞モデルを用いたCav 1.2イオン選択性を障害するCACNA1C-E1115K変異がQT 延長症候群、Brugada 症候群を発症するメカニズムの解析2020
- Author(s)
  柏麻美, 牧山武, 糀谷泰, マウリッセントーマス, ウリヤンハイイミン, 山本雄大, ガオジンシャン, ファンハイ, 今村知彦, 相澤卓範, 石川泰輔, 大野聖子, 豊田太, 佐藤誠一, 高橋一浩, ウォルツェンクヌート, 堀江稔, 蒔田直昌, 木村剛
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Inhibition of Late Sodium Current Attenuates Prolonged Action Potential Durations in CACNA1C-E1115K iPS Cell Model with Disrupted Cav1.2 ion Selectivity2020
- Author(s)
  Asami Kashiwa, Takeru Makiyama, Hirohiko Kohjitani, Thomas Maurissen, Yimin Wuriyanghai, Yuta Yamamoto, Jingshan Gao, Hai Huang, Tomohiko Imamura, Takanori Aizawa, Taisuke Ishikawa, Seiko Ohno, Futoshi Toyoda, Seiich Sato, Kazuhiro Takahashi, Knut Woltjen, Minoru Horie, Naomasa Makita, Takeshi Kimura
- Organizer
  The Heart Rhythm Society's Annual Scientific Sessions 2020 (HRS2020)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Preclinical Proof-of-concept of Antisense-mediated Transcript Knockdown Therapy in Calmodulinopathy2020
- Author(s)
  Yuta Yamamoto, Takeru Makiyama, Yoshiki Kondo, Yusuke Iriyama, Ryutarou Ishikawa, Jingshan Gao, Hirohiko Kohjitani, Asami Kashiwa, Takanori Aizawa, Tomohiko Imamura, Hai Huang, Taisuke Ishikawa, Yoshinori Yoshida, Seiko Ohno, Minoru Horie, Naomasa Makita, Takeshi Kimura.
- Organizer
  第14回日本循環器学会基礎研究フォーラム（BCVR2020）
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] iPS Cell-Based Inherited Arrhythmia Disease Modeling. iPSCs: Limitations and Future challenges. Cardiac Arrhythmias2020
- Author(s)
  Makiyama T.
- Organizer
  第84回日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08416
[Presentation] CALM2-N98S Mutation Associated with Long QT Syndrome Impaired the Response of KCNQ1 Channel to Beta-adrenergic Stimulation in Human iPSC-derived Cardiomyocytes.2020
- Author(s)
  Yuta Yamamoto, Takeru Makiyama, Yimin Wuriyanghai, Hirohiko Kohjitani, Sayako Hirose, Jingshan Gao, Asami Kashiwa, Huang Hai, Takanori Aizawa, Tomohiko Imamura, Taisuke Ishikawa, Hideki Motomura, Yoshinori Yoshida, Seiko Ohno, Minoru Horie, Naomasa Makita, Takeshi Kimura.
- Organizer
  第84回日本循環器学会学術集会（JCS2020）
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Inhibition of Late Sodium Current Attenuates Prolonged Action Potential Durations in CACNA1C-E1115K iPS Cell Model with Disrupted Cav1.2 ion Selectivity2020
- Author(s)
  Asami Kashiwa, Takeru Makiyama et al.
- Organizer
  第14回日本循環器学会基礎研究フォーラム（BCVR2020）
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Clinical and genetic aspects of pediatric Brugada syndrome2020
- Author(s)
  Imamura T, Makiyama T, Sumitomo N, Horie M et al.
- Organizer
  European Society of Cardiology Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] iPS Cell-Based Inherited Arrhythmia Disease Modeling. iPSCs: Limitations and Future challenges. Cardiac Arrhythmias2020
- Author(s)
  Takeru Makiyama
- Organizer
  第84回日本循環器学会学術集会（JCS2020）
- Invited
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Inhibition of Late Sodium Current Attenuates Prolonged Action Potential Durations in CACNA1C-E1115K iPS Cell Model with Disrupted Cav1.2 ion Selectivity2020
- Author(s)
  Yamamoto Y, Makiyama T, Kondo Y, Iriyama Y, Ishikawa R, Kimura T et al.
- Organizer
  The Heart Rhythm Society's Annual Scientific Sessions 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08416
[Presentation] Preclinical Proof-of-Concept Study: Antisense-mediated Knockdown of CALM as a Therapeutic Strategy for Calmodulinopathy2020
- Author(s)
  Yuta Yamamoto, Takeru Makiyama, Yoshiki Kondo, Yusuke Iriyama, Ryutarou Ishikawa, Yimin Wuriyanghai, Hirohiko Kohjitani, Sayako Hirose, Jingshan Gao, Asami Kashiwa, Huang Hai, Takanori Aizawa, Tomohiko Imamura, Taisuke Ishikawa, Yoshinori Yoshida, Seiko Ohno, Minoru Horie, Naomasa Makita, Takeshi Kimura
- Organizer
  European Society of Cardiology (ESC) Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] 患者由来iPS細胞分化心筋モデルを用いた不整脈疾患の病態解析、創薬への応用2020
- Author(s)
  牧山武
- Organizer
  第97回日本生理学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] 患者由来iPS細胞モデルを用いたCav 1.2イオン選択性を障害するCACNA1C-E1115K変異がQT延長症候群、Brugada症候群を発症するメカニズムの解析2020
- Author(s)
  Asami Kashiwa, Takeru Makiyama, Hirohiko Kohjitani, Thomas Maurissen, Yimin Wuriyanghai, Yuta Yamamoto, Jiungshan Gao, Huang Hai, Tomohiko Imamura, Takanori Aizawa, Taisuke Ishikawa, Seiko Ohno, Futoshi Toyoda, Seiich Sato, Kazuhiro Takahashi, Knut Woltjen, Minoru Horie, Naomasa Makita, Takeshi Kimura.
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Inhibition of Late Sodium Current Attenuates Prolonged Action Potential Durations in CACNA1C-E1115K iPS Cell Model with Disrupted Cav1.2 ion Selectivity2020
- Author(s)
  Kashiwa A, Makiyama T, Ishikawa T, Makita N, Kimura T et al.
- Organizer
  The Heart Rhythm Society's Annual Scientific Sessions 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Clinical and genetic aspects of pediatric Brugada syndrome2020
- Author(s)
  Imamura T, Makiyama T, Sumitomo N, Horie M et al.
- Organizer
  European Society of Cardiology Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08416
[Presentation] Human Induced Pluripotent Stem Cell Model of CACNA1C-E1115K which Impairs Ion Selectivity of the Cardiac L-type Calcium Channel2020
- Author(s)
  Asami Kashiwa, Takeru Makiyama, Thomas Maurissen, Hirohiko Kohjitani, Yimin Wuriyanghai, Yuta Yamamoto, Jungshan Gao, Huang Hai, Tomohiko Imamura, Takanori Aizawa, Taisuke Ishikawa, Seiko Ohno, Futoshi Toyoda, Seiich Sato, Kazuhiro Takahashi, Knut Woltjen, Minoru Horie, Naomasa Makita, Takeshi Kimura.
- Organizer
  第84回日本循環器学会学術集会（JCS2020）
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] iPS Cell-Based Inherited Arrhythmia Disease Modeling. iPSCs: Limitations and Future challenges. Cardiac Arrhythmias2020
- Author(s)
  Makiyama T.
- Organizer
  第84回日本循環器学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Preclinical Proof-of-Concept Study: Antisense-mediated Knockdown of CALM as a Therapeutic Strategy for Calmodulinopathy2020
- Author(s)
  Yamamoto Y, Makiyama T, Kondo Y, Iriyama Y, Ishikawa R, Kimura T et al.
- Organizer
  European Society of Cardiology Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08416
[Presentation] Structural Insights into Catecholaminergic Polymorphic Ventricular Tachycardia-associated RyR2 Mutant Channels using a Three-dimensional In Silico Model.2019
- Author(s)
  Gao J., Makiyama T., Ohno S., YamamotoY., Wuriyanghai Y., Kohjitani H., Kashiwa A., Huang H., Katou K., Horie M., Kimura T.
- Organizer
  European Society of Cardiology Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Single Cell Electrophysiological Analysis of iPS Cell-Derived Cardiomyocytes Generated from Long-QT Syndrome Patients Carrying a CALM2 Mutation Using a Membrane Potential Imaging System2019
- Author(s)
  Yamamoto Y., Makiyama T., Wuriyanghai Y., Kohjitani H., Hirose S., Gao J., Kashiwa A., Huang H., Ishikawa T., Ohno S., Chonabayashi K., Suda K., Yoshida Y., Horie M., Makita N., Kimura T.
- Organizer
  第66回日本不整脈心電学会
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] KCNQ1 Channel Dysfunction in human induced pluripotent stem cell-derived cardiomyocytes carrying a CALM2-N98S mutation associated with long QT syndrome2019
- Author(s)
  Yuta Yamamoto, Takeru Makiyama, Yimin Wuriyanghai, Hirohiko Kohjitani, Sayako Hirose, Jingshan Gao, Asami Kashiwa, Huang Hai, Takanori Aizawa, Tomohiko Imamura, Taisuke Ishikawa, Seiko Ohno, Kazuhisa Chonabayashi, Hideki Motomura, Yoshinori Yoshida, Minoru Horie, Naomasa Makita, Takeshi Kimura
- Organizer
  American Heart Association Scientific Sessions 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Overlapping Sick Sinus Syndrome Associated with SCN5A Mutations in Patients with Brugada Syndrome2019
- Author(s)
  Kashiwa A., Makiyama T., Ohno S., Aoki H., Kohjitani H., Wuriyanghai Y., Yamamoto Y., Gao J., Hai H., Horie M., Kimura T.
- Organizer
  第83回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Modeling Overlap Syndrome of Long QT and Brugada Syndrome Associated with Induced Pluripotent Stem Cells2019
- Author(s)
  Kashiwa A, Makiyama T, Kohjitani H, Wuriyanghai Y, Yamamoto Y, Jungshan G, Huang H, Ishikawa T, Ohno S, Toyoda F, Sato S, Horie M, Makita N, Kimura T.
- Organizer
  The 40th Heart Rhythm Society Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Patients characteristics of idiopathic ventricular fibrillation carrying SCN5A mutations without Brugada or long QT syndrome.2019
- Author(s)
  Takanori Aizawa, Takeru Makiyama, Hai Huang, Tomohiko Imamura, JingShan Gao, Yimin Wuriyanghai, Takeru Makiyama, Yuta Yamamoto, Hirohiko Kohjitani, Sayako Hirose, Jingshan Gao, Asami Kashiwa, Hai Huang, Wuriyanghai Yimin, Hirohiko Kohjitani, Yuta Yamamoto, Seiko Ohno, Minoru Horie
- Organizer
  12th Asia Pacific Heart Rhythm Society Scientific Session (APHRS2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Algorithmic Auto-Recreation System of hiPSC-CMs Simulation and Prediction of Drug Testing.2019
- Author(s)
  Hirohiko Kohjitani, Shigeya Kouda, Yukiko Himeno, Takeru Makiyama, Hai Huang, Jingshan Gao, Asami Kashiwa, Yimin Wuriyanghai, Daisuke Yoshinaga, Takeshi Kimura, Akira Amano.
- Organizer
  第66回日本不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Genetics and Clinical Aspects of Congenital Long-QT Syndrome: Results from the Japanese Multicenter Registry2019
- Author(s)
  清水渉, 山形研一郎, 野田崇, 草野研吾, 宮崎文, 牧山武, 伊藤英樹, 大野聖子, 渡部裕, 林研至, 森田宏, 吉永正夫, 福田恵一, 宮本恵宏, 鎌倉史郎, 田中敏博, 住友直方, 萩原誠久, 蒔田直昌, 堀江稔, 相庭武司
- Organizer
  第83回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Challenges of iPS cell-Based Disease Modeling and Therapeutic Approaches to Inherited Arrhythmias2019
- Author(s)
  Makiyama T.
- Organizer
  第3回日本循環器学会基礎研究フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Single Cell Electrophysiological Analysis of iPS Cell-derived Cardiomyocytes Generated from Long-QT Syndrome Patients Carrying a CALM2 Mutation Using a Membrane Potential Imaging System.2019
- Author(s)
  Yuta Yamamoto, Takeru Makiyama(代発表), Yimin Wuriyanghai, Hirohiko Kohjitani, Sayako Hirose, Jingshan Gao, Asami Kashiwa, Huang Hai, Taisuke Ishikawa, Seiko Ohno, Kazuhisa Chonabayashi, Kenji Suda, Yoshinori Yoshida, Minoru Horie, Naomasa Makita, Takeshi Kimura,
- Organizer
  第66回日本不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Response of KCNQ1 to Adrenergic Stimulation was Impaired in Human Induced Pluripotent Stem Cell-derived Cardiomyocytes Carrying a CALM2-N98S Mutation Associated with Long QT Syndrome.2019
- Author(s)
  Yuta Yamamoto, Takeru Makiyama, Yimin Wuriyanghai, Hirohiko Kohjitani, Sayako Hirose, Jingshan Gao, Asami Kashiwa, Huang Hai, Takanori Aizawa, Tomohiko Imamura, Taisuke Ishikawa, Seiko Ohno, Kazuhisa Chonabayashi, Hideki Motomura, Yoshinori Yoshida, Minoru Horie, Naomasa Makita, Takeshi Kimura
- Organizer
  12th Asia Pacific Heart Rhythm Society Scientific Session (APHRS2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] KCNQ1 Channel Dysfunction in human induced pluripotent stem cell-derived cardiomyocytes carrying a CALM2-N98S mutation associated with long QT syndrome2019
- Author(s)
  Yamamoto Y, Makiyama T, Ishiakawa T, Makita N, Kimura T et al.
- Organizer
  American Heart Association Scientific Sessions 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Modeling Overlapping Phenotypes of Long-QT and Brugada Syndrome with CACNA1C-E1115K that Alters Ion Selectivity of the Cardiac L-Type Calcium Channel Using Induced Pluripotent Stem Cells2019
- Author(s)
  Kashiwa A, Makiyama T, Kohjitani H, Hirose S, Gao J, Kashiwa A, Huang H, Ishikawa T, Ohno S, Chonabayashi K, Suda K, Yoshida Y, Horie M, Makita N, Kimura T.
- Organizer
  第66回日本不整脈心電学会
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Overlapping Sick Sinus Syndrome Associated with SCN5A Mutations in Patients with Brugada Syndrome2019
- Author(s)
  Asami Kashiwa, Takeru Makiyama, Seiko Ohno, Hisaaki Aoki, Hirohiko Kohjitani Yimin Wuriyanghai, Yuta Yamamoto, Jingshan Gao, Huang Hai, Minoru Horie, Takeshi Kimura.
- Organizer
  第83回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Algorithmic Auto-Recreation System of hiPSC-CMs Simulation and Prediction of Drug Testing2019
- Author(s)
  Kohjitani H., Kouda S., Himeno Y., Makiyama T., Huang H., Gao J., Kashiwa A., Wuriyanghai Y., Yoshinaga D., Kimura T., Amano A.
- Organizer
  第83回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Automatic Computational Action Potential Analyzing System Enables Accurate Drug Response Interpretation and Prediction in Human Induced Pluripotent Stem Cell-derived Cardiomyocytes2019
- Author(s)
  Hirohiko Kohjitani, Shigeya Kouda, Yukiko Himeno, Takeru Makiyama, Asami Kashiwa, Yimin Wuriyanghai, Yuta Yamamoto, Minoru Horie, Takeshi Kimura, Akinori Noma, Akira Amano.
- Organizer
  40th Heart Rhythm Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Morphological and electrophysiological characterization of homozygous lamin A/C knockout human induced-pluripotent stem cell-derived cardiomyocytes. American Heart Association Scientific Sessions 20192019
- Author(s)
  Yimin Wuriyanghai, Takeru Makiyama, Yuta Yamamoto, Hirohiko Kohjitani, Sayako Hirose, Jingshan Gao, Asami Kashiwa, Hai Huang, Takanori Aizawa, Tomohiko Imamura, Seiko Ohno, Minoru Horie, Takeshi Kimura
- Organizer
  American Heart Association Scientific Sessions 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Single Cell Electrophysiological Analysis of iPS Cell-Derived Cardiomyocytes Generated from Long-QT Syndrome Patients Carrying a CALM2 Mutation Using a Membrane Potential Imaging System2019
- Author(s)
  Yamamoto Y, Makiyama T, Wuriyanghai Y, Kohjitani H, Hirose S, Gao J, Kashiwa A, Huang H, Ishikawa T, Ohno S, Chonabayashi K, Suda K, Yoshida Y, Horie M, Makita N, Kimura T.
- Organizer
  第66回日本不整脈心電学会
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Three-Dimensional Structural Analysis of Mutant Ryanodine Receptor Type 2 Channels Associated with Catecholaminergic Polymorphic Ventricular Tachycardia.2019
- Author(s)
  Jingshan Gao, Takeru Makiyama, Seiko Ohno, Yuta Yamamoto, Yimin Wuriyanghai, Hirohiko Kohjitani, Asami Kashiwa, Minoru Horie, Takeshi Kimura.
- Organizer
  第83回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Modeling Overlapping Phenotypes of Long-QT and Brugada Syndrome with CACNA1C-E1115K that Alters Ion Selectivity of the Cardiac L-Type Calcium Channel Using Induced Pluripotent Stem Cells.2019
- Author(s)
  Asami Kashiwa, Takeru Makiyama, Hirohiko Kohjitani, Yimin Wuriyanghai, Yuta Yamamoto, Jingshan Gao, Hai Huang, Taisuke Ishikawa, Seiko Ohno, Futoshi Toyoda, Seiichi Sato, Minoru Horie, Naomasa Makita, Takeshi Kimura
- Organizer
  第66回日本不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Modeling Overlap Syndrome Of Long QT And Brugada Syndrome Associated With CACNA1C-E1115K Which Alters Ion Selectivity With Induced Pluripotent Stem Cells2019
- Author(s)
  Asami Kashiwa, Takeru Makiyama, Hirohiko Kohjitani, Yimin Wuriyanghai, Yuta Yamamoto, Gao Jungshan, Hai Huang, Taisuke Ishikawa, Seiko Ohno, Futoshi Toyoda, , Seiichi Sato, Minoru Horie , Naomasa Makita, Takeshi Kimura.
- Organizer
  40th Heart Rhythm Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Automatic Computational Action Potential Analyzing System Enables Accurate Drug Response Interpretation and Prediction in Human Induced Pluripotent Stem Cell-derived Cardiomyocytes2019
- Author(s)
  Kohjitani H., Kouda S., Himeno Y., Makiyama T., Kashiwa A., Wuriyanghai Y., Yamamoto Y., Horie M., Kimura T., Noma A., Amano A.
- Organizer
  The 40th Heart Rhythm Society Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Modeling Overlap Syndrome of Long QT and Brugada Syndrome Associated with Induced Pluripotent Stem Cells2019
- Author(s)
  Kashiwa A., Makiyama T., Kohjitani H., Wuriyanghai Y., Yamamoto Y., Jungshan G., Huang H., Ishikawa T., Ohno S., Toyoda F., Sato S., Horie M., Makita N., Kimura T.
- Organizer
  The 40th Heart Rhythm Society Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Algorithmic Auto-Recreation System of hiPSC-CMs Simulation and Prediction of Drug Testing.2019
- Author(s)
  Hirohiko Kohjitani, Shigeya Kouda, Yukiko Himeno, Takeru Makiyama, Asami Kashiwa, Yimin Wuriyanghai, Yuta Yamamoto, Minoru Horie, Takeshi Kimura, Akinori Noma, Akira Amano
- Organizer
  12th Asia Pacific Heart Rhythm Society Scientific Session (APHRS2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] 40th Heart Rhythm Scientific Sessions2019
- Author(s)
  Kohitani H, Kouda S, Himeno Y, Makiyama T, Kashiwa A, Wuriyanghai Y, Ymamaoto Y, Hiroe M, Kimura T, Noma A, Amano A.
- Organizer
  40th Heart Rhythm Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Morphological and electrophysiological characterization of homozygous lamin A/C knockout human induced-pluripotent stem cell-derived cardiomyocytes. American Heart Association Scientific Sessions 20192019
- Author(s)
  Wuriyanghai Y, Makiyama T, Yamamoto Y, Horie M, Kimura T.
- Organizer
  American Heart Association Scientific Sessions 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Complex aberrant splicing in the induce pluripotent stem cell-derived cardiomyocytes from a patient with long-QT syndrome carrying KCNQ1-A344Aspl mutation.2019
- Author(s)
  Wuriyanghai Y, Makiyama T, Sasaki K, Kamakura T, Yamamoto Y, Hayano M, Harita T, Nishiuchi S, Chen J, Kohjitani H, Hirose S, Yokoi F, Gao J, Chonabayashi K, Watanabe K, Ohno S, Yoshida Y, Kimura T, Horie M
- Organizer
  第66回日本不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Phenotype-based High-throughput Classification of Long-QT Syndrome Subtypes Using Human Induced Pluripotent Stem Cells.2019
- Author(s)
  Daisuke Yoshinaga, Shiro Baba, Takeru Makiyama, Hirofumi Shibata, Takuya Hirata, Kentaro Akagi, Koichi Matsuda, Hirohiko Kohjitani, Yimin Wuriyanghai, Katsutsugu Umeda, Yuta Yamamoto, Bruce R. Conklin, Minoru Horie, Junko Takita, Toshio Heike.
- Organizer
  第66回日本不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Structural Insights into Catecholaminergic Polymorphic Ventricular Tachycardia-associated RyR2 Mutant Channels using a Three-dimensional In Silico Model2019
- Author(s)
  Gao J, Makiyama T, Ohno S, Yamamoto Y, Wuriyanghai Y, Kohjitani H, Kashiwa A, Huang H, Katou K, Horie M, Kimura T.
- Organizer
  European Society of Cardiology Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Algorithmic Auto-Recreation System of hiPSC-CMs Simulation and Prediction of Drug Testing2019
- Author(s)
  Hirohiko Kohjitani, Shigeya Kouda, Yukiko Himeno, Takeru Makiyama, Hai Huang, Jingshan Gao, Asami Kashiwa, Yimin Wuriyanghai, Daisuke Yoshinaga, Takeshi Kimura, Akira Amano.
- Organizer
  第83回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Three-Dimensional Structural Analysis of Mutant Ryanodine Receptor Type 2 Channels Associated with Catecholaminergic Polymorphic Ventricular Tachycardia2019
- Author(s)
  Gao J., Makiyama T., Ohno S., Yamamoto Y., Wuriyanghai Y., Kohjitani H., Kashiwa A, Horie M., Kimura T.
- Organizer
  第83回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Challenges of iPS cell-Based Disease Modeling and Therapeutic Approaches to Inherited Arrhythmias2019
- Author(s)
  Takeru Makiyama
- Organizer
  第 3回日本循環器学会基礎研究フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Structural Insights into Catecholaminergic Polymorphic Ventricular Tachycardia-associated RyR2 Mutant Channels using a Three-dimensional in Silico Model.2019
- Author(s)
  Jingshan Gao, Takeru Makiyama, Seiko Ohno, Yuta Yamamoto, Yimin Wuriyanghai, Hirohiko Kohjitani, Asami Kashiwa, Hai Huang, Kouichi Katou, Minoru Horie, Takeshi Kimura.
- Organizer
  第66回日本不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Structural Insights into Catecholaminergic Polymorphic Ventricular Tachycardia-associated RyR2 Mutant Channels using a Three-dimensional In Silico Model.2019
- Author(s)
  J. Gao, T. Makiyama, S. Ohno, Y. Yamamoto, Y. Wuriyanghai, H. Kohjitani, A. Kashiwa, H. Huang, K. Katou, M. Horie, T. Kimura.
- Organizer
  European Society of Cardiology Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08538
[Presentation] Modeling Overlapping Phenotypes of Long-QT and Brugada Syndrome with CACNA1C-E1115K that Alters Ion Selectivity of the Cardiac L-Type Calcium Channel Using Induced Pluripotent Stem Cells2019
- Author(s)
  Kashiwa A., Makiyama T., Kohjitani H., Hirose S., Gao J., Kashiwa A., Huang H., Ishikawa T., Ohno S., Chonabayashi K., Suda K., Yoshida Y., Horie M., Makita N., Kimura T.
- Organizer
  第66回日本不整脈心電学会
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Human induced pluripotent stem cell models for inherited arrhythmias2018
- Author(s)
  Makiyama T.
- Organizer
  The 2018 International Congress on Electrocardiology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Overlapping Sick Sinus Syndrome Associated with SCN5A Mutations in Patients with Brugada Syndrome2018
- Author(s)
  Asami Kashiwa, Takeru Makiyama, Seiko Ohno, Hisaaki Aoki, Hirohiko Kohjitani Yimin Wuriyanghai, Yuta Yamamoto, Jingshan Gao, Huang Hai, Minoru Horie, Takeshi Kimura
- Organizer
  第83回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Significance of cell-specific precise computer simulation using new mathematical models of human induced pluripotent stem cell derived cardiomyocyte in drug testing2018
- Author(s)
  Hirohiko Kohjitani, Shigeya Kouda, Yukiko Himeno, Takeru Makiyama, Fumika Yokoi, Sayako Hirose, Yimin Wuriyanghai, Yuta Yamamoto, Minoru Horie, Takeshi Kimura, Akinori Noma, Akira Amano
- Organizer
  European Society of Cardiology Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Rare Coding Variants in Genes Other Than SCN5A Are Minimal Genetic Burden on the Prognosis of Brugada Syndrome2018
- Author(s)
  Ishikawa T., Mishima H., Ohno S., T. Aiba, Nakano Y., Aizawa Y., Nakajima T., Hayashi K., Murakoshi N., Yagihara N., Kimoto H., Makiyama T., Watanabe H., Morita H., Yoshiura K., Nogami A., Shimizu W., Horie M., Tanaka T., Makita N.
- Organizer
  The 65th Annual Meeting of the Japan Heart Rhythm Society
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Modelling long-QT syndrome with human iPS cells and development of new pharmacotherapies2018
- Author(s)
  Takeru Makiyama
- Organizer
  23rd International Society of Cardiovascular Pharmacotherapy (ISCP)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Clinical Manifestations and Long-term Mortality in Lamin A/C Mutation Carriers from the Japanese Multicenter Registry2018
- Author(s)
  Nakajima K., Aiba T., Makiyama T., Nishiuchi S., Ohno S., Doi T., Shizuta S., Onoue K., Yagihara N., Ishikawa T., Watanabe I., Oginosawa Y., Nogami A., Aonuma K., Saitoh Y., Kimura T., Makita N., Shimizu W., Horie M., Kusano K.
- Organizer
  The 65th Annual Meeting of the Japan Heart Rhythm Society
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] CALM2関連性QT延長症候群iPSCモデルにおいて、l-cis-diltiazemは遅延したL型calciumチャネルの不活性化をさらに強める2018
- Author(s)
  横井文香, 牧山武, 山本雄大, 張田健志, Yimin Wuriyanghai, 早野護, 西内英, 糀谷泰彦, 廣瀬紗也子, 高景山, 大野聖子, 豊田太, 吉田善紀, 蒔田直昌, 堀江稔, 木村剛
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04823
[Presentation] Three-dimensional Structural Analysis of Mutant Ryanodine Receptor Type 2 Channels Associated with Catecolaminergic Polymorphic Ventricular Tachycardia2018
- Author(s)
  Gao J., Makiyama T., Ohno S., Yamamoto Y., Wuriyanghai Y., Kohjitani H., Kashiwa A., Hirose S., Horie M., Kimura T.
- Organizer
  The 11th Asia Pacific Heart Rhythm Society Scientific Session
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Rare Coding Variants in Genes Other Than SCN5A Are Minimal Genetic Burden on the Prognosis of Brugada Syndrome2018
- Author(s)
  Ishikawa T., Mishima H., Ohno S., T. Aiba, Nakano Y., Aizawa Y., Nakajima T., Hayashi K., Murakoshi N., Yagihara N., Kimoto H., Makiyama T., Watanabe H., Morita H., Yoshiura K., Nogami A., Shimizu W., Horie M., Tanaka T., Makita N.
- Organizer
  The 65th Annual Meeting of the Japan Heart Rhythm Society
- Data Source
  KAKENHI-PROJECT-15H04823
[Presentation] Human induced pluripotent stem cell models for inherited arrhythmias2018
- Author(s)
  Takeru Makiyama
- Organizer
  The 2018 International Congress on Electrocardiology (ICE 2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Torsadogenic Action Of Late Na+ Current In Experimental Electrical Storm2018
- Author(s)
  Yamamoto Y., Makiyama T, Wuriyanghai Y., Kohjitani H., Hirose S., Gao J, Kashiwa A., Kimura T., Ishikawa T., Motomura H., Makita N, Ohno S., Chonabayashi K., Yoshida Y., Suda K., Horie M
- Organizer
  The 11th Asia Pacific Heart Rhythm Society Scientific Session
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Modelling calmodulin-related long-QT syndrome using human iPS cells: therapeutic genome editing using CRISPR/Cas9 system2018
- Author(s)
  Takeru Makiyama
- Organizer
  第65回日本不整脈心電学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] The inactivation of L-type Ca2+ Channel was impaired in Human iPS Cell Model of Long-QT Syndrome with CALM2-D134H Mutation.2018
- Author(s)
  Yamamoto Y., Makiyama T., Harita T., Hayano M., Nishiuchi S., Wuriyanghai Y., Kohjitani H., Hirose S., Yokoi F., Ishikawa T., Ohno S., Chonabayashi K., Suda K., Yoshida Y., Horie M., Makita N., Kimura T.
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Symposium 5: Sudden Cardiac Death─Elucidation of Pathogenesis, Prediction, and Prevention─: Induced pluripotent stem cell-based modeling of inherited arrhythmias2018
- Author(s)
  牧山　武
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] CALM2関連性QT延長症候群iPSCモデルにおいて、l-cis-diltiazemは遅延したL型calciumチャネルの不活性化をさらに強める2018
- Author(s)
  横井文香, 牧山武, 山本雄大, 張田健志, Yimin Wuriyanghai, 早野護, 西内英, 糀谷泰彦, 廣瀬紗也子, 高景山, 大野聖子, 豊田太, 吉田善紀, 蒔田直昌, 堀江稔, 木村剛
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Can patient-derived iPSCs be applied to phenotypic cell-based high throughput screening assessment to distinguish between different types of long-QT syndrome?2018
- Author(s)
  Daisuke Yoshinaga, Shiro Baba, Hirofumi Shibata, Takuya Hirata, Takeru Makiyama, Ryuta Nishikomori
- Organizer
  European Society of Cardiology Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Modelling calmodulin-related long-QT syndrome using human iPS cells: therapeutic genome editing using CRISPR/Cas9 system2018
- Author(s)
  Makiyama T.
- Organizer
  第65回日本不整脈心電学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Analysis of Disease-Causing Mechanism of Lamin A/C-Related Cardiomyopathy Using Homozygous Lamin A/C Knock out Human Induced Pluripotent Stem Cell Model2018
- Author(s)
  Wuriyanghai Y., Makiyama T., Yamamoto Y., Nishiuchi S., Hirose S., Kohjitani H., Gao J., Kashiwa A., Ohno S., Horie M., Kimura T.
- Organizer
  The 11th Asia Pacific Heart Rhythm Society Scientific Session
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Significance of cell-specific precise computer simulation using new mathematical models of human induced pluripotent stem cell derived cardiomyocyte in drug testing2018
- Author(s)
  Kohjitani H., Kouda S., Himeno Y., Makiyama T., Yokoi F., Hirose S., Wuriyanghai Y., Yamamoto Y., Horie M., Kimura T., Noma A., Amano A.
- Organizer
  European Society of Cardiology Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Clinical Manifestations and Long-term Mortality in Lamin A/C Mutation Carriers from the Japanese Multicenter Registry2018
- Author(s)
  Nakajima K., Aiba T., Makiyama T., Nishiuchi S., Ohno S., Doi T., Shizuta S., Onoue K., Yagihara N., Ishikawa T., Watanabe I., Oginosawa Y., Nogami A., Aonuma K., Saitoh Y., Kimura T., Makita N., Shimizu W., Horie M., Kusano K.
- Organizer
  The 65th Annual Meeting of the Japan Heart Rhythm Society
- Data Source
  KAKENHI-PROJECT-15H04823
[Presentation] The inactivation of L-type Ca2+ Channel was impaired in Human iPS Cell Model of Long-QT Syndrome with CALM2-D134H Mutation.2018
- Author(s)
  Yamamoto Y., Makiyama T., Harita T., Hayano M., Nishiuchi S., Wuriyanghai Y., Kohjitani H., Hirose S., Yokoi F., Ishikawa T., Ohno S., Chonabayashi K., Suda K., Yoshida Y., Horie M., Makita N., Kimura T.
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04823
[Presentation] Analysis of Disease-Causing Mechanism of Lamin A/C-Related Cardiomyopathy Using Homozygous Lamin A/C Knock out Human Induced Pluripotent Stem Cell Model2018
- Author(s)
  Yimin Wuriyanghai, Takeru Makiyama, Yuta Yamamoto, Suguru, Nishiuchi, Sayako Hirose, Hirohiko Kohjitani, Jingshan Gao, Asami Kashiwa, Seiko Ohno, Minoru Horie, Takeshi Kimura
- Organizer
  The 11th Asia Pacific Heart Rhythm Society Scientific Session
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Three-dimensional Structural Analysis of Mutant Ryanodine Receptor Type 2 Channels Associated with Catecolaminergic Polymorphic Ventricular Tachycardia2018
- Author(s)
  Jingshan Gao, Takeru Makiyama, Seiko Ohno, Yuta Yamamoto, Yimin Wuriyanghai, Hirohiko Kohjitani, Asami Kashiwa, Sayako Hirose, Minoru Horie, Takeshi Kimura
- Organizer
  The 11th Asia Pacific Heart Rhythm Society Scientific Session
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Modelling long-QT syndrome with human iPS cells and development of new pharmacotherapies2018
- Author(s)
  Makiyama T.
- Organizer
  23rd International Society of Cardiovascular Pharmacotherapy
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Can patient-derived iPSCs be applied to phenotypic cell-based high throughput screening assessment to distinguish between different types of long-QT syndrome?2018
- Author(s)
  Yoshinaga D, Baba S, Shibata H, Hirata T, Makiyama T., Nishikomori R.
- Organizer
  European Society of Cardiology Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02808
[Presentation] Single Cell Electrophysiological Analysis of Human iPS Cell-Derived Cardiomyocytes Generated from Long-QT Syndrome Patients Carrying a CALM2 Mutation Using a Membrane Voltage Imaging System2018
- Author(s)
  Yamamoto Y., Makiyama T, Wuriyanghai Y., Kohjitani H., Hirose S., Gao J, Kashiwa A., Kimura T., Ishikawa T., Motomura H., Makita N, Ohno S., Chonabayashi K., Yoshida Y., Suda K., Horie M
- Organizer
  The 11th Asia Pacific Heart Rhythm Society Scientific Session
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04823
[Presentation] CALM2-D134H Mutation Associated With Long-QT Syndrome Delayed Inactivation of L-type Ca2+ Currents in Human iPS Cells Derived Cardiomyocytes.2017
- Author(s)
  Yamamoto Y, Makiyama T, Harita T, Hayano M, Nishiuchi S, Wuriyanghai Y, Kohjitani H, Hirose S, Yokoi F, Ishikawa T, Ohno S, Chonabayashi K, Suda K, Yoshida Y, Horie M, Makita N, Kimura T.
- Organizer
  American Heart Association Annual Scientific Session 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15311
[Presentation] Development of Homozygous LaminA/C Deficient Human Induced Pluripotent Stem Cell Model for Analyzing the Pathophysiological Mechanism of Lamin A/C-related Cardiomyopathy2017
- Author(s)
  Wuriyanghai Yimin、牧山武
- Organizer
  第1回日本循環器学会基礎研究フォーラム（BCVR）
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Gene-Based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers2017
- Author(s)
  Nishiuchi S, Makiyama T, Aiba T, Nakajima K, Ishikawa T, Murakoshi N, Watanabe H, Ohno S, Doi T, Shizuta S, Minamino T, Saito Y, Oginosawa Y, Nogami A, Aonuma K, Kusano K, Makita N, Shimizu W, Horie M, Kimura T.
- Organizer
  The 10th Asia Pacific Heart Rhythm Sosiety Scientific Session
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04823
[Presentation] CALM2-D134H Mutation Associated with Long-QT Syndrome Delayed Inactivation of L-type Ca2+ Currents in Human iPS Cells Derived Cardiomyocytes2017
- Author(s)
  山本雄大、牧山武
- Organizer
  American Heart Association (AHA) Scientific Sessions 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] General Symposium 3: Inherited arrhythmia syndromes: from bench to bedside: Modelling inherited arrhythmias using human iPS cells: a tool for developing a new therapeutic approach2017
- Author(s)
  牧山武
- Organizer
  the 10th Asia Pacific Heart Rhythm Society Scientific Session (APHRS2017) and the 64th Annual Meeting of the Japanese Heart Rhythm Society (JHRS2017)
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] lL-cis-Diltiazem Ameliorates Impaired Calcium Channel Inactivation in a Patient-Specific Stem Cell Model of Long-QT Syndrome with a Calmodulin Mutation.2017
- Author(s)
  Yokoi F, Makiyama T, Harita T, Yamamoto Y, Hayano M, Nishiuchi S, Kohjitani H, Wuriyanghai Y, Hirose S, Toyoda F, Yoshida Y, Makita N、Horie M, Kimura T
- Organizer
  APHRS2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Gene-Based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers in Japan2017
- Author(s)
  Nishiuchi S, Aiba T, Makiyama T, Nakajima K, Yagihara N, Ishikawa T, Onoue K, Murakoshi N, Watanabe I, Ohkubo K, Watanabe H, Ohno S, Doi T, Shizuta S, Minamino T, Saito Y, Oginosawa Y, Nogami A, Aonuma K, Kusano K, Makita N, Shimizu W, Horie M, Kimura T.
- Organizer
  American Heart Association Annual Scientific Session 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04823
[Presentation] lL-cis-Diltiazem Ameliorates Impaired Calcium Channel Inactivation in a Patient-Specific Stem Cell Model of Long-QT Syndrome with a Calmodulin Mutation2017
- Author(s)
  Yokoi F, Makiyama T, Harita T, Yamamoto Y, Hayano M, Nishiuchi S, Kohjitani H, Wuriyanghai Y, Hirose S, Toyoda F, Yoshida Y, Makita N, Horie M, Kimura T.
- Organizer
  The 10th Asia Pacific Heart Rhythm Society Scientific Session
- Data Source
  KAKENHI-PROJECT-15K15311
[Presentation] Modelling long-QT syndrome type 3 associated with near-miss sudden infant death syndrome using human-induced pluripotent stem cells2017
- Author(s)
  廣瀬紗也子、牧山武
- Organizer
  American Heart Association (AHA) Scientific Sessions 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Human iPSC Model of SCN5A-D1275N-Related Cardiac Sodium Channelopathy Reveals Diminished Sodium Currents Resulting from Proteasomal Degradation2017
- Author(s)
  早野護、牧山武
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Human iPSC-Derived Myocyte Mmodel of SCN5A-D1275N-Related Cardiac Sodium Channelopathy Reveals Diminished Sodium Currents Resulting From Enhanced Protein Degradation.2017
- Author(s)
  Hayano M,Makiyama T, Kamakura T, Watanabe H, Sasaki K, Funakoshi S, Wuriyanghai Y, Nishiguchi S, Harita T, Yamamoto Y,.Kohjitani H, Hirose S, Yokoi F, Chen J, Baba O, Horie T, Chonabayahi K, Ohno S, Toyoda F, Yoshida Y, Ohno K, Horie M, Kimura T.
- Organizer
  AHA2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] lL-cis-Diltiazem Ameliorates Impaired Calcium Channel Inactivation in a Patient-Specific Stem Cell Model of Long-QT Syndrome with a Calmodulin Mutation2017
- Author(s)
  Yokoi F, Makiyama T, Harita T, Yamamoto Y, Hayano M, Nishiuchi S, Kohjitani H, Wuriyanghai Y, Hirose S, Toyoda F, Yoshida Y, Makita N, Horie M, Kimura T.
- Organizer
  The 10th Asia Pacific Heart Rhythm Society Scientific Session
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04823
[Presentation] l-cis-Diltiazem ameliorates impaired calcium channel inactivation in a patient-specific stem cell model of long-QT syndrome with a calmodulin mutation2017
- Author(s)
  横井文香、牧山武
- Organizer
  the 10th Asia Pacific Heart Rhythm Society Scientific Session (APHRS2017) and the 64th Annual Meeting of the Japanese Heart Rhythm Society (JHRS2017)
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] CALM2-D134H Mutation Associated with Long-QT Syndrome Delayed Inactivation of L-type Ca2+ Currents in Human iPS Cells Derived Cardiomyocytes.2017
- Author(s)
  Yamamoto Y, Makiyama T, Harita T, Hayano M, Suguru N, Wuriyanghai Y, Kohjitani H, Hirose S, Yokoi F, Ishikawa T, Ohno S, Chonabayashi K, Suda K, Yoshida Y, Horie M, Makita N, Kimura T.
- Organizer
  AHA2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Cell-specific Precise Mathematical Modeling of hiPSC-CMs Revealed Two Opposite APD Reaction in IKr Blocking Test2017
- Author(s)
  糀谷泰彦、牧山武
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] CALM2-D134H Mutation associated with long-QT Syndrome delayed inactivation of L-type Ca2+ currents in human iPS cells derived cardiomyocytes2017
- Author(s)
  山本雄大、牧山武
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Gene-based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers2017
- Author(s)
  西内英、牧山武
- Organizer
  第81回日本循環器学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Propranolol attenuates late sodium current in patient-specific stem cell model of long-QT syndrome type 32017
- Author(s)
  廣瀬紗也、牧山武
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Invited Symposium 66 (Basic/Genetic-10): Sodium Channel Diseases: Sodium channel diseases: AT/AF/DCM2017
- Author(s)
  牧山武
- Organizer
  the 10th Asia Pacific Heart Rhythm Society Scientific Session (APHRS2017) and the 64th Annual Meeting of the Japanese Heart Rhythm Society (JHRS2017)
- Invited
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Human iPSC model of CALM2-D134H Mutation Associated with Long-QT Syndrome2017
- Author(s)
  山本雄大、牧山武
- Organizer
  第1回日本循環器学会基礎研究フォーラム（BCVR）
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Allele-specific Disruption Rescues Electrophysiological Abnormalities in Human iPS Cell Model of Long-QT Syndrome with a CALM2 Mutation2017
- Author(s)
  山本雄大、牧山武
- Organizer
  第81回日本循環器学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Gene-Based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers.2017
- Author(s)
  Nishiuchi S, Makiyama T, Aiba T, Nakajima K, Ishikawa T, Murakoshi N, Watanabe H, Ohno S, Doi T, Shizuta S, Minamino T, Saito Y, Oginosawa Y, Nogami A, Aonuma K, Kusano K, Makita N, Shimizu W, Horie M, Kimura T
- Organizer
  APHRS2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Gene-based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers2017
- Author(s)
  西内英、牧山武
- Organizer
  European Society of Cardiology (ESC) Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Development of a phenotype-based and high-throughput diagnostic protocol for long-QT syndrome using iPSC model2017
- Author(s)
  吉永大介、牧山武
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Gene-Based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers2017
- Author(s)
  Nishiuchi S, Makiyama T, Aiba T, Nakajima K, Ishikawa T, Murakoshi N, Watanabe H, Ohno S, Doi T, Shizuta S, Minamino T, Saito Y, Oginosawa Y, Nogami A, Aonuma K, Kusano K, Makita N, Shimizu W, Horie M, Kimura T.
- Organizer
  The 10th Asia Pacific Heart Rhythm Sosiety Scientific Session
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15311
[Presentation] l-cis-Diltiazem ameliorates impaired calcium channel inactivation in a patient-specific stem cell model of long-QT syndrome with a calmodulin mutation2017
- Author(s)
  横井文香、牧山武
- Organizer
  Basic Cardiovascular Sciences (BCVS) Scientific Sessions 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Allele-specific ablation rescues electrophysiological abnormalities in a human iPS cell model of long-QT syndrome with a CALM2 mutation2017
- Author(s)
  Yamamoto Y, Makiyama T, Harita T, Sasaki K, Wuriyanghai Y, Nishiuchi S, Kohjitani H, Hirose S, Ishikawa T, Motomura H, Ohno S, Yoshida Y, Horie M, Makita N, Kimura T.
- Organizer
  第81回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04823
[Presentation] Novel Mathematical Modeling of Human Induced Pluripotent Stem Cell Derived Cardiomyocyte can Recapitulate Action Potentials of All Subtypes Including Nodal Like Cells, and Reproduced Drug Testing and Gene Mutation Model Accurately.2017
- Author(s)
  Kohjitani K, Kouda S, Himeno Y, Makiyama T, Hirose S, Wuriyanghai Y, Yamamoto Y, Horie M, Kimura T, Noma A, Amano A.
- Organizer
  AHA2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] l-cis-Diltiazem enhances slowed L-type calcium channel inactivation in CALM2-associated long-QT syndrome iPSC model2017
- Author(s)
  横井文香、牧山武
- Organizer
  第1回日本循環器学会基礎研究フォーラム（BCVR）
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Gene-Based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers in Japan2017
- Author(s)
  Nishiuchi S, Aiba T, Makiyama T, Nakajima K, Yagihara N, Ishikawa T, Onoue K, Murakoshi N, Watanabe I, Ohkubo K, Watanabe H, Ohno S, Doi T, Shizuta S, Minamino T, Saito Y, Oginosawa Y, Nogami A, Aonuma K, Kusano K, Makita N, Shimizu W, Horie M, Kimura T.
- Organizer
  American Heart Association Annual Scientific Session 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15311
[Presentation] ヒトiPS細胞由来心筋細胞のサブタイプに応じた数理モデルの構築と解析2017
- Author(s)
  糀谷泰彦、牧山武
- Organizer
  第三回国際心血管薬物療法学会日本部会（J-ISCP）学術集会
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Novel Mathematical Models of All Subtypes of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes2017
- Author(s)
  糀谷泰彦、牧山武
- Organizer
  American Heart Association (AHA) Scientific Sessions 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Gene-Based Risk Stratification for Cardiac Disorders in LMNA Mutation Carriers in Japan2017
- Author(s)
  西内英, 相庭武司、牧山武
- Organizer
  American Heart Association (AHA) Scientific Sessions 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Exercise Inducible Polymorphic Ventricular Tachycardia Depending on the Different RYR2 Mutation Spectrum2017
- Author(s)
  Wada Y, Ohno S, Wuriyanghai Y, Makiyama T, Horie M
- Organizer
  APHRS2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Modelling long-QT syndrome type 3 associated with near-miss sudden infant death syndrome using human-induced pluripotent stem cells2017
- Author(s)
  廣瀬紗也子、牧山武
- Organizer
  the 10th Asia Pacific Heart Rhythm Society Scientific Session (APHRS2017) and the 64th Annual Meeting of the Japanese Heart Rhythm Society (JHRS2017)
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Cell-specific Precise Mathematical Modeling of hiPSC-CMs Revealed Two Opposite APD Reaction in IKr Blocking Test2017
- Author(s)
  糀谷泰彦、牧山武
- Organizer
  第1回日本循環器学会基礎研究フォーラム（BCVR）
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Genotype-Phenotype Correlation of SCN5A Mutations for the Clinical and Electrocardiographic Characteristics of Probands with Brugada Syndrome: A Japanese Multicenter Registry2017
- Author(s)
  Yamagata K, Horie M, Aiba T, Ogawa S, Aizawa Y, Ohe T, Yamagishi M, Makita N, Sakurada H, Tanaka T, Shimizu A, Hagiwara N, Kishi R, Nakano Y, Takagi M, Makiyama T, Ohno S, Fukuda K, Watanabe H, Morita H, Hayashi K, Fukushima-Kusano K, Kamakura S, Yasuda S, Ogawa H, Y. M, Kapplinger J, Ackerman M, Shimizu W.
- Organizer
  第81回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04823
[Presentation] Propranolol Inhibits Late Sodium Current in Long-QT Syndrome Type 3 Human Induced Pluripotent Stem Cell-drived Myocyte Model.2017
- Author(s)
  irose S, Makiyama T, Melgari D, Wu J, Yokoi F, Wuriyanghai Y, Yamamoto Y, Kohjitani H, Nishiguchi S, Harita T, Hayano M, Yoshimoto J, Ohno S, Yoshida Y, Horie M, Kimura T.
- Organizer
  AHA2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Development of Homozygous LaminA/C Deficient Human Induced Pluripotent Stem Cell Model for Analyzing the Pathophysiological Mechanism of Lamin A/C-related Cardiomyopathy2017
- Author(s)
  Wuriyanghai Yimin、牧山武
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Score System for Diagnosis of Syncope after Alcohol Intake in Brugada Syndrome.2017
- Author(s)
  Wu Q, Hira D, Hayashi H, Sonoda K, Ohno S, Makiyama T, Terada T, Horie M.
- Organizer
  APHRS2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] 医学薬学ジョイントシンポジウム―再生技術を用いた治療法開発―：遺伝性不整脈疾患における患者由来iPS細胞を用いた病態解明、治療法開発2017
- Author(s)
  牧山武
- Organizer
  第三回国際心血管薬物療法学会日本部会（J-ISCP）学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] CALM2-D134H Mutation Associated with Long-QT Syndrome Prevents Inactivation of L-type Ca2+ Currents in Human iPS Cell Derived Cardiomyocytes.2017
- Author(s)
  Yamamoto Y, Makiyama T, Harita T, Hayano M, Nishiuchi S, Wuriyanghai Y, Kohjitani H, Hirose S, Yokoi F, Ishikawa T, Ohno S, Chinabayashi K, Suda K, Yoshida Y, Horie M, Makita N, Kimura T.
- Organizer
  The 10th Asia Pacific Heart Rhythm Society Scientific Session
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15311
[Presentation] Allele-specific ablation rescues electrophysiological abnormalities in a human iPS cell model of long-QT syndrome with a CALM2 mutation2017
- Author(s)
  Yamamoto Y, Makiyama T, Harita T, Sasaki K, Wuriyanghai Y, Nishiuchi S, Kohjitani H, Hirose S, Ishikawa T, Motomura H, Ohno S, Yoshida Y, Horie M, Makita N, Kimura T.
- Organizer
  第81回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K15311
[Presentation] Symposium 5: Sudden Cardiac Death─Elucidation of Pathogenesis, Prediction, and Prevention─: Induced pluripotent stem cell-based modeling of inherited arrhythmias2017
- Author(s)
  牧山武
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] CALM2-D134H Mutation Associated with Long-QT Syndrome Prevents Inactivation of L-type Ca2+ Currents in Human iPS Cell Derived Cardiomyocytes.2017
- Author(s)
  Yamamoto Y, Makiyama T, Harita T, Hayano M, Nishiuchi S, Wuriyanghai Y, Kohjitani H, Hirose S, Yokoi F, Ishikawa T, Ohno S, Chinabayashi K, Suda K, Yoshida Y, Horie M, Makita N, Kimura T.
- Organizer
  The 10th Asia Pacific Heart Rhythm Society Scientific Session
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04823
[Presentation] Genotype-Phenotype Correlation of SCN5A Mutations for the Clinical and Electrocardiographic Characteristics of Probands with Brugada Syndrome: A Japanese Multicenter Registry2017
- Author(s)
  Yamagata K, Horie M, Aiba T, Ogawa S, Aizawa Y, Ohe T, Yamagishi M, Makita N, Sakurada H, Tanaka T, Shimizu A, Hagiwara N, Kishi R, Nakano Y, Takagi M, Makiyama T, Ohno S, Fukuda K, Watanabe H, Morita H, Hayashi K, Fukushima-Kusano K, Kamakura S, Yasuda S, Ogawa H, Y. M, Kapplinger J, Ackerman M, Shimizu W.
- Organizer
  第81回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K15311
[Presentation] Identification of copy number variations by next generation sequencer in patients with inherited primary arrhythmia syndromes.2017
- Author(s)
  Ichikawa M, Ohno S, Fukumoto D, Takayama K, Wada Y, Fukuyama M, Makiyama T, Itoh H, Horie M
- Organizer
  ESC Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] CALM2-D134H Mutation Associated with Long-QT Syndrome Prevents Inactivation of L-type Ca2+ Currents in Human iPS Cells Derived Cardiomyocytes2017
- Author(s)
  山本雄大、牧山武
- Organizer
  the 10th Asia Pacific Heart Rhythm Society Scientific Session (APHRS2017) and the 64th Annual Meeting of the Japanese Heart Rhythm Society (JHRS2017)
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Mathematical Modeling and Analysis of Electrophysiological Characteristics of the ventricular, atrial, and nodal-like hiPSC-CMs2017
- Author(s)
  糀谷泰彦、牧山武
- Organizer
  the 10th Asia Pacific Heart Rhythm Society Scientific Session (APHRS2017) and the 64th Annual Meeting of the Japanese Heart Rhythm Society (JHRS2017)
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Next-Generation Sequencing Is One of the Promising Ways for Identifying Copy Number Variations in Patients with Inherited Primary Arrhythmia Syndromes.2017
- Author(s)
  Ichikawa M, Ohno S, Fukumoto D, Takayama K, Wada Y, Fukuyama M, Makiyama T, Itoh H, Horie M
- Organizer
  APHRS2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] CALM2-D134H Mutation Associated with Long-QT Syndrome Prevents Inactivation of L-type Ca2+ Currents in Human iPS Cell Derived Cardiomyocytes.2017
- Author(s)
  Yamamoto Y, Makiyama T, Harita T, Hayano M, Nishiuchi S, Wuriyanghai Y, Kohjitani H, Hirose S, Yokoi F, Ishikawa T, Ohno S, Chinabayashi K, Suda K, Yoshida Y, Horie M, Makita N, Kimura T.
- Organizer
  APHRS2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Is Cardiac Resynchronization Therapy Able to Improve Mortality of Heart Failure in Patients with Laminopathy?2017
- Author(s)
  Nakajima K, Aiba T, Nishiuchi S, Makiyama T, Onoue K, Kamakura T, Wada M, Ishibashi K, Inoue Y, Miyamoto K, Okamura H, Nagase S, Noda T, Ohno S, Miyamoto Y, Saito Y, Horie M, Kimura T, Shimizu W, Kusano K.
- Organizer
  APHRS2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Cell-specific Precise Mathematical Modeling of hiPSC-CMs Revealed Two Opposite APD Reaction in IKr Blocking Test2017
- Author(s)
  糀谷泰彦、牧山武
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Human iPSC-Derived Myocyte Model of SCN5A-D1275N-Related Cardiac Sodium Channelopathy Reveals Diminished Sodium Currents Resulting From Enhanced Protein Degradation2017
- Author(s)
  早野護、牧山武
- Organizer
  American Heart Association (AHA) Scientific Sessions 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Invited Symposium 67 (Basic/Genetic-11): iPS Cells in Arrhythmia Research: Modelling congenital long-QT syndrome type 8 using patient-derived iPS cells2017
- Author(s)
  牧山武
- Organizer
  the 10th Asia Pacific Heart Rhythm Society Scientific Session (APHRS2017) and the 64th Annual Meeting of the Japanese Heart Rhythm Society (JHRS2017)
- Invited
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] CALM2-D134H Mutation Associated With Long-QT Syndrome Delayed Inactivation of L-type Ca2+ Currents in Human iPS Cells Derived Cardiomyocytes.2017
- Author(s)
  Yamamoto Y, Makiyama T, Harita T, Hayano M, Nishiuchi S, Wuriyanghai Y, Kohjitani H, Hirose S, Yokoi F, Ishikawa T, Ohno S, Chonabayashi K, Suda K, Yoshida Y, Horie M, Makita N, Kimura T.
- Organizer
  American Heart Association Annual Scientific Session 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04823
[Presentation] Establishment of Homozygous LMNA Knockout Human Induced Pluripotent Stem Cells For Analyzing Disease-causing Mechanism of Laminopathies2017
- Author(s)
  Wuriyanghai Yimin、牧山武
- Organizer
  American Heart Association (AHA) Scientific Sessions 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Development of a phenotype-based and high-throughput diagnostic test for long-QT syndrome using iPSC model2017
- Author(s)
  吉永大介、牧山武
- Organizer
  the 10th Asia Pacific Heart Rhythm Society Scientific Session (APHRS2017) and the 64th Annual Meeting of the Japanese Heart Rhythm Society (JHRS2017)
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] l-cis-Diltiazem enhances slowed L-type calcium channel inactivation in CALM2-associated long-QT syndrome iPSC model2017
- Author(s)
  横井文香、牧山武
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Modelling Long-QT Syndrome Type 3 Associated　with Near-Miss Sudden Infant Death Syndrome Using Human-Induced Pluripotent Stem Cells.2017
- Author(s)
  Hirose S, Makiyama T, Melgari D, Wu J, Yokoi F, Wuriyanghai Y, Kohjitani H, Yamamoto Y, Nishiuchi S, Hayano M, Harita T, Yoshimoto J, Ohno S, Yoshida Y, Horie M, Kimura T
- Organizer
  APHRS2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Triple mutations in three major genes for long QT syndrome are very rare but produce severe phenotypes.2016
- Author(s)
  Ohno S, Wu J, Sonoda K, Itoh H, Makiyama T, Horie M
- Organizer
  ESC CONGRESS 2016
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-08-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Electrophysiological Features of Patient-specific Human-induced Pluripotent Stem Cell-derived Cardiomyocytes Carrying the SCN5A-D1275N Mutation2016
- Author(s)
  早野　護、牧山　武
- Organizer
  日本循環器学会
- Place of Presentation
  仙台、仙台国際会議場
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-15K15311
[Presentation] Copy Number Variations in SCN5A associated with Brugada Syndrome.2016
- Author(s)
  Sonoda K, Ohno S, Ozawa J, Hayano M, Ichikawa M, Ito H, Makiyama T, Horie M
- Organizer
  ESC CONGRESS 2016
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-08-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Various ANK2 mutations in patients with inherited primary arrhythmia syndromes.2016
- Author(s)
  Ichikawa M, Aiba T, Ohno S, Shigemizu D, Ozawa J, Sonoda K, Fukuyama M, Itoh H, Miyamoto Y, Tsunoda T, Makiyama T, Tanaka T, Shimizu W, Horie M
- Organizer
  9th APHRS Scientific Session
- Place of Presentation
  Korea
- Year and Date
  2016-10-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] l-cis diltiazem rescues impaired calcium channel inactivation in a patient-specific stem cell model of long-QT syndrome with a CACNA1C mutation2016
- Author(s)
  張田健志、牧山武
- Organizer
  第63回日本不整脈心電学会学術大会
- Place of Presentation
  札幌
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Abnormal expressions of cardiac ion channels-associated genes in lamin A/C-related cardiomyopathy-specific induced pluripotent stem cell-derived cardiomyocytes2016
- Author(s)
  西内　英、牧山　武
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] Modeling of long-QT syndrome associated with a calmodulin mutation using human induced pluripotent stem cells2016
- Author(s)
  Yamamoto Y, Makiyama T, Harita T, Sasaki K, Hayano M, Nishiuchi S, Wuriyanghai Y, Kohjitani H, Hirose S, Cheng J, Ishikawa T, Ohno S, Yoshida Y, Horie M, Makita N, Kimura T.
- Organizer
  第63回日本不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-15H04823
[Presentation] Triple mutations in three major genes for long QT syndrome are very rare and cause complicated phenotypes with ventricular arrhythmia.2016
- Author(s)
  Ohno S, Wu J, Mizusawa Y, Sonoda K, Itoh H, Makiyama T, Horie M
- Organizer
  ESC2016
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-08-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Allele-specific Disruption Rescues Electrophysiological Abnormalities in Human iPS Cell Model of Long-QT Syndrome With a CALM2 Mutation2016
- Author(s)
  Yamamoto Y, Makiyama T, Harita T, Sasaki K, Hayano M, Nishiuchi S, Wuriyanghai Y, Kohjitani H, Hirose S, Chen J, Ishikawa T, Motomura H, Ohno S, Chonabayashi K, Yoshida Y, Horie M, Makita N, Kimura T.
- Organizer
  AHA2016,
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Generation of LMNA knockout human induced pluripotent stem cell lines using the CRISPR/Cas9 nickase system2016
- Author(s)
  Yimin Wuriyanghai、牧山武
- Organizer
  2016 9th Asia Pacific Heart Rhythm Society (APHRS 2016)
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-10-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Patient-Specific Induced Pluripotent Stem-Cell Models a missense mutation in the KCNH2 gene2016
- Author(s)
  糀谷泰彦、牧山武
- Organizer
  第63回日本不整脈心電学会学術大会
- Place of Presentation
  札幌
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] High prevalence of late onset T in patients with long QT syndrome type 8.2016
- Author(s)
  Ohno S, Ozawa J, Fukuyama M, Makiyama T, Horie M.
- Organizer
  AHA2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Generation of lmna knock out human induced pluripotent stem cells using the crispr-cas9 nickase system.2016
- Author(s)
  Wuriyanghai Y, Makiyama T, Nishiuchi S, Yokoi F, Hayano M, Yamamoto Y, Harita T, Kohjitani H, Hirose A, Ohno S, Yoshida Y, Horie M, Kimura T
- Organizer
  9th APHRS Scientific Session
- Place of Presentation
  Korea
- Year and Date
  2016-10-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Electrophysiological Features of Patient-specific Human-induced Pluripotent Stem Cell-derived Cardiomyocytes Carrying the SCN5A-D1275N Mutation2016
- Author(s)
  早野　護、牧山　武
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] Rare Single Nucleotide Polymorphism of SCN10A in Patients with Inherited Primary Arrhythmia Syndromes.2016
- Author(s)
  Fukuyama M, Ohno S, Ichikawa M, Makiyama T, Horie M
- Organizer
  ESC CONGRESS 2016
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-08-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Allele-specific Disruption Rescues Electrophysiological Abnormalities in Human iPS Cell Model of Long-QT Syndrome with a CALM2 Mutation2016
- Author(s)
  山本雄大、牧山武
- Organizer
  American Heart Association (AHA) Scientific Sessions 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] l-cis diltiazem rescues impaired calcium channel inactivation in a patient-specific stem cell model of long QT syndrome with a CACNA1C mutation.2016
- Author(s)
  Harita T, Makiyama T, Toyoda F, Nishiuchi S, Hayano M, Yamamoto Y, Wuriyanghai Y, Kohjitani H, Ohno S, Yoshida Y, Ueyama T, Yamanaka S, Shimizu A, Horie M, Kimura T
- Organizer
  ESC2016
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-08-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Electrophysiological Features of Patient-specific Human-induced Pluripotent Stem Cell-derived Cardiomyocytes Carrying the SCN5A-D1275N Mutation2016
- Author(s)
  早野　護、牧山　武
- Organizer
  日本循環器学会
- Place of Presentation
  仙台、仙台国際会議場
- Year and Date
  2016-03-18
- Invited
- Data Source
  KAKENHI-PROJECT-15H04823
[Presentation] Modeling the long-QT syndrome associated with a calmodulin mutation using2016
- Author(s)
  山本雄大、牧山武
- Organizer
  第63回日本不整脈心電学会学術大会
- Place of Presentation
  札幌
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] Copy number variations in SCN5A associated with Brugada syndrome.2016
- Author(s)
  Sonoda K, Ohno S, Ozawa J, Hayano M, Ito H, Makiyama T, Horie M
- Organizer
  ESC2016
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-08-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] l-cis diltiazem rescues impaired calcium channel inactivation in a patient-specific stem cell model of long-QT syndrome with a CACNA1C mutation2016
- Author(s)
  張田健志、牧山武
- Organizer
  European Society of Cardiology Congress 2016 (ESC Congress 2016)
- Place of Presentation
  Roma, Italy
- Year and Date
  2016-08-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] The Phenotype in Cardiomyocytes Derived from Induced Pluripotent Stem Cells of Long QT Syndrome type 8 Patients without Extracardiac Phenotypes2016
- Author(s)
  張田　健志、牧山　武
- Organizer
  第80回日本循環器学会学術集会
- Place of Presentation
  仙台
- Year and Date
  2016-03-18
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] Rare single nucleotide polymorphism of scn10a in patients with inherited primary arrhythmia syndromes.2016
- Author(s)
  Fukuyama M, Ohno S, Ichikawa M, Makiyama T, Horie M
- Organizer
  ESC2016
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-08-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Modeling of long-QT syndrome associated with a calmodulin mutation using human induced pluripotent stem cells2016
- Author(s)
  Yamamoto Y, Makiyama T, Harita T, Sasaki K, Hayano M, Nishiuchi S, Wuriyanghai Y, Kohjitani H, Hirose S, Cheng J, Ishikawa T, Ohno S, Yoshida Y, Horie M, Makita N, Kimura T.
- Organizer
  第63回日本不整脈心電学会学術大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Data Source
  KAKENHI-PROJECT-15K15311
[Presentation] Electrophysiological Features of Patient-Specific Human-induced Pluripotent Stem Cell-Derived Cardiomyocytes Carrying the SCN5A-D1275N Mutation2016
- Author(s)
  早野　護、牧山武
- Organizer
  第63回日本不整脈心電学会学術大会
- Place of Presentation
  札幌
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-16K09499
[Presentation] A novel CACNA1C mutation identified in a patient with atypical Timothy syndrome exerts both loss- and gain-of-function effects on Cav1.2.2016
- Author(s)
  Ozawa J, Ohno S, Toyoda F, Itoh H, Fukuyama M, Harita T, Makiyama T, Hiroshi Suzuki, Akihiko Saitoh, Matsuura H, Horie M
- Organizer
  ESC CONGRESS 2016
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-08-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Generation of TRPM4 knock out human induced pluripotent stem cells by genome editing using the CRISPR-Cas9 nickase2015
- Author(s)
  山本雄大、牧山　武
- Organizer
  第30回日本不整脈学会学術大会／第32回日本心電学会学術集会
- Place of Presentation
  京都
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] Genetic Backgrounds of Patients with Clinically Diagnosed Idiopathic Ventricular Fibrillation2015
- Author(s)
  糀谷　泰彦、牧山　武
- Organizer
  日本循環器学会
- Place of Presentation
  大阪、大阪国際会議場
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-15K15311
[Presentation] Lamin A/C-related cardiomyopthy―From Bench to Bedside―2015
- Author(s)
  Makiyama T, Nishiuchi S, Kohjitani H, Ohno S, Horie M, Kimura T
- Organizer
  第30回日本不整脈学会学術大会
- Place of Presentation
  京都
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Modeling of long-QT syndrome associated with a calmodulin mutation using human induced pluripotent stem cells2015
- Author(s)
  山本　雄大、牧山　武
- Organizer
  American Heart Association Scientific Sessions (AHA) 2015
- Place of Presentation
  Orland, United States
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] Electrophysiological Properties of L-type Calcium Channels in Human Induced Pluripotent Stem Cells-Derived Cardiomyocytes2015
- Author(s)
  張田　健志、牧山　武
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] Cardiac Sodium Channel Mutation Associated With Epinephrine-Induced QT Prolongation and Sinus Node Dysfunction,2015
- Author(s)
  陳嘉容、牧山　武
- Organizer
  日本不整脈学会／日本心電学会
- Place of Presentation
  京都、京都国際会議場
- Year and Date
  2015-07-28
- Invited
- Data Source
  KAKENHI-PROJECT-15H04823
[Presentation] Paediatric Cardiac Inherited Disease: The latest on the treatment of CPVT in children2015
- Author(s)
  牧山　武
- Organizer
  8th Asia-Pacific Heart Rhythm Scientific Session
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2015-11-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] S107 rescues arrhythmogenic phenotype in a patient specific-induced stem cell-based model of catecholaminergic polymorphic ventricular tachycardia2015
- Author(s)
  佐々木　健一、牧山　武
- Organizer
  第30回日本不整脈学会学術大会／第32回日本心電学会学術集会
- Place of Presentation
  京都
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] Modelling Long-QT Syndrome Associated With a Calmodulin Mutation Using Human Induced Pluripotent Stem Cells2015
- Author(s)
  Yamamoto Y, Makiyama T, Harita T, Sasaki K, Hayano H, Nishiuchi S, Wuriyanghai Y, Kohjitani H, Hirose S, Chen J, Ishikawa T, Ohno S, Yoshida Y, Horie M, Makita N, Kimura T.
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  アメリカ合衆国
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Structural and Electrophysiological Characteristic of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes,2015
- Author(s)
  牧山　武
- Organizer
  日本循環器学会
- Place of Presentation
  大阪、大阪国際会議場
- Year and Date
  2015-04-24
- Invited
- Data Source
  KAKENHI-PROJECT-15H04823
[Presentation] Cardiac sodium channel mutation associated with epinephrine-induced QT prolongation and sinus node dysfunction.2015
- Author(s)
  Chen J, Makiyama T, Wuriyanghai Y, Ohno S, Ueyama T, Shimizu A, Horie M, Kimur T.
- Organizer
  ESC CONGRESS 2015
- Place of Presentation
  イギリス
- Year and Date
  2015-08-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Genetic Backgrounds of Patients with Clinically Diagnosed Idiopathic Ventricular Fibrillation2015
- Author(s)
  糀谷　泰彦、牧山　武
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] Usefulness of Benchtop Next Generation Sequencer in Research of Inherited Primary Arrhythmia Syndromes2015
- Author(s)
  Ohno S,Fukuyama M,Itoh H,Makiyama T,Horie M
- Organizer
  第79回日本循環器学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Advances in Diagnosis and Management of CPVT: Prevention of Sudden death in CPVT: who gets an ICD?2015
- Author(s)
  牧山　武
- Organizer
  8th Asia-Pacific Heart Rhythm Scientific Session
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2015-11-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] The genetics underlying the acquired long QT syndrome. Impact on management.2015
- Author(s)
  Itoh H, Spazzolini C, Crotti L, Aiba T, Denjoy I, Fressart V, Hayashi K, Nakajima T, Ohno S, Makiyama T, Wu J, Hasegawa K, Mastantuono E, Dagradi F, Pedrazzini M, Yamagishi M, Berthet M, Murakami Y, Shimizu W, Guicheney P, Schwartz PJ, Horie M.
- Organizer
  The Heart Rhythm Society's 36th Annual Scientific Sessions
- Place of Presentation
  アメリカ合衆国
- Year and Date
  2015-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] LMNA Related Cardiomyopathy Specific Induced Pluripotent Stem Cells derived Cardiomyocytes Stressed by Adrenergic Stimulation Recapitulate the Aging Related Phenotype in an Early Phase of Differentiation2015
- Author(s)
  西内　英、牧山　武
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] Cardiac Sodium Channel Mutation Associated With Epinephrine-Induced QT Prolongation and Sinus Node Dysfunction2015
- Author(s)
  陳嘉容、牧山　武
- Organizer
  第30回日本不整脈学会学術大会／第32回日本心電学会学術集会
- Place of Presentation
  京都
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] ML277 shortens prolonged action potential durations in a patient-specific induced pluripotent stem cell-based model of long-QT syndrome type 12015
- Author(s)
  Yimin Wuriyanghai、牧山　武
- Organizer
  第30回日本不整脈学会学術大会／第32回日本心電学会学術集会
- Place of Presentation
  京都
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] desmosome gene mutations cause or modify the Brugada syndrome?2015
- Author(s)
  Ohno S, Aizawa Y,Fukuyama M,Makiyama T,Kosaki K,Fukuda K,Horie M
- Organizer
  The Heart Rhythm Society's 36th Annual Scientific Sessions
- Place of Presentation
  アメリカ合衆国
- Year and Date
  2015-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Differential Diagnosis of Catecholaminergic Polymorphic Ventricular Tachycardia vs. Long QT Syndrome Type 1: A Modified Schwartz Scoring2015
- Author(s)
  Ozawa J, Ohno S, Fujii Y, Makiyama T, Suzuki H, Saitoh A, Horie M.
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  アメリカ合衆国
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Abnormal expression of cardiac ion channels-associated genes in lamin A/C-related cardiomyopathy-specific induced pluripotent stem cell derived cardiomyocytes2015
- Author(s)
  Nishiuchi S, Makiyama T, Sasaki K, Kohjitani Y, Ohno S, Yoshida Y, Doi T, Shizuta S, Horie.M, Kimura T
- Organizer
  ESC CONGRESS 2015
- Place of Presentation
  イギリス
- Year and Date
  2015-08-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Drug challenge test and genetic test for the diagnosis and management ofinherited primary arrhythmia syndromes2015
- Author(s)
  Ueyama T, Shimizu A, Yoshiga Y, Ono M,Kato T, Fumimoto T, Ishiguchi H, Ohno S, Makiyama T, Horie M, Yano M
- Organizer
  第30回日本不整脈学会学術大会
- Place of Presentation
  京都
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Structural and Electrophysiological Characteristic of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes2015
- Author(s)
  牧山　武
- Organizer
  第79回日本循環器学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2015-04-24
- Invited
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] Abnormal expressions of cardiac ion channels-associated genes in lamin A/C-related cardiomyopathy-specific induced pluripotent stem cell-derived cardiomyocytes2015
- Author(s)
  西内　英、牧山武
- Organizer
  European Society of Cardiology (ESC) Congress 2015
- Place of Presentation
  London, United Kingdom
- Year and Date
  2015-08-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] Structural and Electrophysiological Characteristic of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes,2015
- Author(s)
  牧山　武
- Organizer
  日本循環器学会
- Place of Presentation
  大阪、大阪国際会議場
- Year and Date
  2015-04-24
- Invited
- Data Source
  KAKENHI-PROJECT-15K15311
[Presentation] Identification of Novel SCN10A Mutations in Brugada Syndrome Patients.2015
- Author(s)
  Fukuyama M,Ohno S,Makiyama T,Horie M
- Organizer
  第79回日本循環器学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Genetic Backgrounds of Patients with Clinically Diagnosed Idiopathic Ventricular Fibrillation2015
- Author(s)
  糀谷　泰彦、牧山　武
- Organizer
  日本循環器学会
- Place of Presentation
  大阪、大阪国際会議場
- Year and Date
  2015-04-24
- Invited
- Data Source
  KAKENHI-PROJECT-15H04823
[Presentation] SCN10A polymorphisms are associated with the clinical severity of probands with sodium channelopathies.2015
- Author(s)
  Fukuyama M, Ohno S, Ichikawa M, Makiyama T, Horie M
- Organizer
  EUROPACE- CARDIOSTIM 2015
- Place of Presentation
  イタリア
- Year and Date
  2015-06-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] ML277 shortens prolonged action potential durations in a patientspecific induced pluripotent stem cell-based model of long-QT syndrome　type 12015
- Author(s)
  Wuriyanghai Y, Makiyama T, Sasaki K, Kamakura T, Chen J, Hayano M, Yamamoto Y, Harita T, Nishiuchi S, Kohjitani H, Ohno S, Watanabe K, Kimura T, Horie M
- Organizer
  第30回日本不整脈学会学術大会
- Place of Presentation
  京都
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15H04818
[Presentation] Patient-Specific Induced Pluripotent Stem-Cell Models for Long QT Syndrome with the missense mutation in the CACNA1C gene2015
- Author(s)
  張田　健志、牧山　武
- Organizer
  第30回日本不整脈学会学術大会／第32回日本心電学会学術集会
- Place of Presentation
  京都
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] Cardiac Sodium Channel Mutation Associated With Epinephrine-Induced QT Prolongation and Sinus Node Dysfunction,2015
- Author(s)
  陳嘉容、牧山　武
- Organizer
  日本不整脈学会／日本心電学会
- Place of Presentation
  京都、京都国際会議場
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15K15311
[Presentation] Disease Modeling in Human Induced Pluripotent Stem Cells-Catecholaminergic Polymorphic Ventricular Tachycardia-2013
- Author(s)
  牧山武
- Organizer
  第77回日本循環器学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24659387
[Presentation] Disease Modeling in Human Induced Pluripotent Stem Cells-Catecholaminergic Polymorphic Ventricular Tachycardia-2013
- Author(s)
  牧山武
- Organizer
  第77回日本循環器学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790848
[Presentation] Disease Modeling in Human Induced Pluripotent Stem Cells -Catecholaminergic Polymorphic Ventricular Tachycardia2013
- Author(s)
  牧山武
- Organizer
  第77回日本循環器学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790848
[Presentation] Disease Modeling in Human Induced Pluripotent Stem Cells -Catecholaminergic Polymorphic Ventricular Tachycardia2013
- Author(s)
  牧山武
- Organizer
  第77回日本循環器学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24659387
[Presentation] iPS細胞由来の不整脈疾患モデル心筋細胞2013
- Author(s)
  牧山　武
- Organizer
  第30回日本心電学会学術集会
- Place of Presentation
  青森
- Invited
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] Phenotypic characteristics between SCN5A and LMNA mutation carriers in familial bradyarrhythmic disorders.2012
- Author(s)
  牧山武
- Organizer
  The 5thAsia-Pacific Heart Rhythm Society (APHRS) Scientific Session
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-24659387
[Presentation] Phenotypic characteristics between SCN5A and LMNA mutation carriers in familial bradyarrhythmic disorders2012
- Author(s)
  牧山武
- Organizer
  The 5th Asia-Pacific Heart Rhythm Society (APHRS) Scientific Session
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-24659387
[Presentation] Analysis of Cardiomyocytes Differentiated from Disease-specific Induced Pluripotent Stem Cells from a Patient with Lamin A/C-related Cardiomyopathy .2012
- Author(s)
  牧山武
- Organizer
  第76回日本循環器学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23790848
[Presentation] nalysis of Cardiomyocytes Differentiated from Disease-specific Induced Pluripotent Stem Cells from a Patient with Lamin A/C-related Cardiomyopathy.2012
- Author(s)
  牧山武
- Organizer
  第76回日本循環器学会学術集会
- Place of Presentation
  福岡国際会議場（福岡）
- Data Source
  KAKENHI-PROJECT-23790848
[Presentation] Phenotypic characteristics between SCN5A and LMNA mutation carriers in familial bradyarrhythmic disorders2012
- Author(s)
  牧山武
- Organizer
  The 5thAsia-Pacific Heart Rhythm Society (APHRS) Scientific Session
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-23790848
[Presentation] Phenotypic characteristics between SCN5A and LMNA mutation carriers in familial bradyarrhythmic disorders2012
- Author(s)
  牧山武
- Organizer
  The 5th Asia-Pacific Heart Rhythm Society (APHRS) Scientific Session
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-23790848
[Presentation] Establishment of Disease-specific Induced Pluripotent Stem Cells from a Patient with Lamin A/C-related Cardiomyopathy.2011
- Author(s)
  牧山武
- Organizer
  第75回日本循環器学会学術集会
- Place of Presentation
  パシフィコ横浜（横浜）
- Data Source
  KAKENHI-PROJECT-23790848
[Presentation] Analysis of Cardiomyocytes Differentiated from Disease-specific Induced Pluripotent Stem Cells from a Patient with Lamin A/C-related Cardiomyopathy.2011
- Author(s)
  牧山武
- Organizer
  American Heart Association 2011
- Place of Presentation
  Orange County Convention Center(Orland, USA)
- Data Source
  KAKENHI-PROJECT-23790848
[Presentation] Analysis of Cardiomyocytes Differentiated from Disease-specific Induced Pluripotent Stem Cells from a Patient with Lamin A/C-related Cardiomyopathy .2011
- Author(s)
  牧山武
- Organizer
  American Heart Association
- Place of Presentation
  Orland, USA
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-23790848
[Presentation] Establishment of Disease-specific Induced Pluripotent Stem Cells from a Patient with Lamin A/C-related Cardiomyopathy2011
- Author(s)
  牧山武
- Organizer
  第75回日本循環器学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790848
[Presentation] Inherited Ventricular Arrhythmic Disorders in Asia : What's New and What's Different from US and Europe?2010
- Author(s)
  牧山武
- Organizer
  Heart Rhythm 2010
- Place of Presentation
  Denver, USA
- Year and Date
  2010-05-15
- Data Source
  KAKENHI-PROJECT-21790720
[Presentation] Both Gain-andLoss-of-Function Mutations in the Cardiac Na+ Channel Gene, SCN5A, are Associated with Sudden Infant Death Syndrome(SIDS).2010
- Author(s)
  牧山武
- Organizer
  第74回日本循環器学学術集会(Focus session)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21790720
[Presentation] Inherited VentricularArrhythmic Disorders in Asia : What's New and What's Different from US and Europe?2010
- Author(s)
  牧山武
- Organizer
  Heart Rhythm
- Place of Presentation
  Denver, USA
- Year and Date
  2010-05-15
- Data Source
  KAKENHI-PROJECT-21790720
[Presentation] Dilated Cardiomyopathy : DCM, Case presentation.2010
- Author(s)
  牧山武
- Organizer
  第74回日本循環器学会学術集会(Focussession)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21790720
[Presentation] Both Gain- and Loss-of-Function Mutations in the Cardiac Na+ Channel Gene, SCN5A, are Associated with Sudden Infant Death Syndrome (SIDS)2010
- Author(s)
  牧山武
- Organizer
  APHRS 2010
- Place of Presentation
  Jeju, Korea
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-21790720
[Presentation] Dilated Cardiomyopathy : DCM, Case presentation2010
- Author(s)
  牧山武
- Organizer
  第74回日本循環器学会学術集会
- Place of Presentation
  京都
- Year and Date
  2010-03-06
- Data Source
  KAKENHI-PROJECT-21790720
[Presentation] Both Gain- and Loss-of-Function Mutations in the Cardiac Na Channel Gene, SCN5A, are Associated with Sudden Infant Death Syndrome (SIDS)2010
- Author(s)
  牧山武
- Organizer
  第74回日本循環器学会学術集会
- Place of Presentation
  京都
- Year and Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-21790720
[Presentation] 学術諮問委員会指定トピックス【不整脈の遺伝子診断】:家族性ペースメーカー植込み症例における遺伝的背景の検討-心臓Na+チャネル病、lamin A/C関連心筋症-2009
- Author(s)
  牧山武
- Organizer
  第24回日本不整脈学会学術大会/第26回日本心電学会学術集会合同学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21790720
[Presentation] 家族性ペースメーカー植込み症例における遺伝的背景の検討-心臓Na+チャネル病、lamin A/C関連心筋症-2009
- Author(s)
  牧山武
- Organizer
  第24回日本不整脈学会学術大会/第26回日本心電学会学術集会合同学術集会
- Place of Presentation
  京都
- Year and Date
  2009-07-02
- Data Source
  KAKENHI-PROJECT-21790720
[Presentation] SCN5A and Lamin A/C genemutations are highly prevalent in patients with familial bradyarrhythmic disorders.2009
- Author(s)
  牧山武
- Organizer
  第73回日本循環器学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21790720
[Presentation] Update in genetics of cardiomyopathy-Laminopathy-
- Author(s)
  牧山　武
- Organizer
  The 7th Asia-Pacific Heart Rhythm Society (APHRS) Scientific Session
- Place of Presentation
  Delhi, India
- Year and Date
  2014-10-29 – 2014-11-01
- Invited
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] Modeling Inherited Arrhythmias Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Application in Personalized Medicine,
- Author(s)
  牧山　武
- Organizer
  第31回日本心電学会学術集会、第29回日本不整脈学会学術大会合同学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-22 – 2014-07-25
- Data Source
  KAKENHI-PROJECT-25461054
[Presentation] Sudden Cardiac Death Risk Assessment　 Risk Stratification of Patients with Brugada Syndrome
- Author(s)
  牧山　武
- Organizer
  The 7th Asia-Pacific Heart Rhythm Society (APHRS) Scientific Session
- Place of Presentation
  Delhi, India
- Year and Date
  2014-10-29 – 2014-11-01
- Invited
- Data Source
  KAKENHI-PROJECT-25461054

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Makiyama Takeru 牧山 武

MAKIYAMA Takeru 牧山 武

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Study of familial sinoatrial node dysfunction using iPS cell-derived subtype-specific cardiomyocytesPrincipal Investigator

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Elucidation of the pathogenesis of lethal inherited arrhythmias using iPS cells and development of therapeutic approachesPrincipal Investigator

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Modeling Inherited Arrhythmia Disorders Using Patient-Derived Induced Pluripotent Stem CellsPrincipal Investigator

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Makiyama Takeru 牧山武

MAKIYAMA Takeru 牧山武

[Journal Article] iPS 細胞を用いた遺伝性不整脈疾患研究の最先端：患者由来iPS 細胞を用いた遺伝性不整脈疾患研究　遺伝性不整脈研究の進歩と臨床応用2023

[Journal Article] Calmodulinopathy in Japanese Children　― Their Cardiac Phenotypes Are Severe and Show Early Onset in Fetal Life and Infancy ―2023