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Kobayashi Hiroki  小林 大貴

ORCIDConnect your ORCID iD *help
Researcher Number 30528683
Other IDs
Affiliation (Current) 2025: 東京薬科大学, 生命科学部, 准教授
Affiliation (based on the past Project Information) *help 2020 – 2024: 東京薬科大学, 生命科学部, 助教
2019: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 研究員
2017: 国立研究開発法人理化学研究所, 吉田化学遺伝学研究室, 協力研究員
2016: 国立研究開発法人理化学研究所, 吉田化学遺伝学研究室, 基礎科学特別研究員
Review Section/Research Field
Principal Investigator
Basic Section 50010:Tumor biology-related / Basic Section 49070:Immunology-related / Tumor biology
Keywords
Principal Investigator
がん代謝 / ケミカルバイオロジー / 急性巨核芽球性白血病 / MDS / 器質化肺炎 / HMGA2 / 骨髄異形成症候群 / PFK1 / 細胞遊走 / 解糖系 / 代謝 / ワールブルグ効果
  • Research Projects

    (4 results)
  • Research Products

    (12 results)
  • Co-Researchers

    (1 People)
  •  急性巨核芽球性白血病治療薬開発のための包括的な白血病細胞分化停止機構解析Principal Investigator

    • Principal Investigator
      小林 大貴
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  A study on the mechanism of pulmonary tissue damage induced by high HMGA2 expression in myelodysplastic syndromesPrincipal Investigator

    • Principal Investigator
      Kobayashi Hiroki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Tokyo University of Pharmacy and Life Science
  •  A study on the mechanism regulating cell motility upon metabolic alterations by PFK1 inhibitionPrincipal Investigator

    • Principal Investigator
      Kobayashi Hiroki
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Tokyo University of Pharmacy and Life Science
      Institute of Physical and Chemical Research
  •  The mechanism of action of a novel small molecule that represses the Warburg effectPrincipal Investigator

    • Principal Investigator
      Kobayashi Hiroki
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Tumor biology
    • Research Institution
      Institute of Physical and Chemical Research

All 2024 2021 2020 2019 2017 Other

All Journal Article Presentation Other

  • [Journal Article] HMGA2 promotes platelet-neutrophil complex formation and pulmonary tissue damage in myelodysplastic syndromes2024

    • Author(s)
      Natsumi Matsunuma, Yoshihiro Hayashi, Marina Fukuda, Kanako Yuki, Yasushige Kamimura-Aoyagi, Hiroki Kobayashi, Naoki Shingai, Yuka Harada, and Hironori Harada
    • Journal Title

      Blood Vessels, Thrombosis & Hemostasis

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07073
  • [Presentation] 機能低下したミトコンドリアを活性化させる化合物の発見とその応用2021

    • Author(s)
      小林大貴、畠山英之、西村はる菜、横田睦美、鈴木禎史、苫米地由里、白水美香子、長田裕之、三牧正和、後藤雄一、吉田稔
    • Organizer
      日本ミトコンドリア学会主催 J-mit 特別オンラインシンポジウム
    • Data Source
      KAKENHI-PROJECT-19K16728
  • [Presentation] 機能低下したミトコンドリアを活性化させる化合物の発見2020

    • Author(s)
      小林大貴、畠山英之、西村はる菜、横田睦美、鈴木禎史、苫米地由里、白水美香子、長田裕之、三牧正和、後藤雄一、吉田稔
    • Organizer
      第43回分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19K16728
  • [Presentation] 解糖系酵素PFK1の合成致死遺伝子同定2019

    • Author(s)
      小林大貴、高瀬翔平、松本健、吉田稔
    • Organizer
      日本ケミカルバイオロジー学会 第14回年会
    • Data Source
      KAKENHI-PROJECT-19K16728
  • [Presentation] Discovery of a small-molecule compound that modulates the Warburg Effect2019

    • Author(s)
      小林大貴、長田裕之、吉田稔
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K16728
  • [Presentation] 解糖系酵素PFK1の合成致死遺伝子の探索2019

    • Author(s)
      小林大貴、高瀬翔平、吉田稔
    • Organizer
      第23回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K16728
  • [Presentation] A novel compound that alters energy metabolism2019

    • Author(s)
      Hiroki Kobayashi, Hiroyuki Osada, and Minoru Yoshida
    • Organizer
      The Joint Symposium of "10th Korea-Japan Chemical Biology Symposium" and "30th Meeting for New Drug Discovery"
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16728
  • [Presentation] Identification of a novel compound that alters energy metabolism2019

    • Author(s)
      Hiroki Kobayashi, Hiroyuki Osada, and Minoru Yoshida
    • Organizer
      Chemical Biology and Drug Discovery, Cold Spring Harbor Asia
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16728
  • [Presentation] ワールブルグ効果を制御する化合物の同定と作用機序解析2017

    • Author(s)
      小林大貴、吉田稔
    • Organizer
      ケミカルバイオロジー学会 第12回年会
    • Data Source
      KAKENHI-PROJECT-16K18432
  • [Presentation] 新規ワールブルグ効果制御化合物の同定と作用機序解析2017

    • Author(s)
      小林大貴、吉田稔
    • Organizer
      第5回 がんと代謝研究会
    • Data Source
      KAKENHI-PROJECT-16K18432
  • [Presentation] がん代謝制御機構の化学遺伝学的解析2017

    • Author(s)
      小林大貴、吉田稔
    • Organizer
      第8回 発酵学フォーラム
    • Data Source
      KAKENHI-PROJECT-16K18432
  • []

  • 1.  原田 浩徳 (10314775)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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