Taniguchi Makoto 谷口真

… Alternative Names

谷口真タニグチマコト

TANIGUCHI Makoto 谷口真

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Researcher Number	30529433
Other IDs
Affiliation (Current)	2022: 金沢医科大学, 総合医学研究所, 講師
Affiliation (based on the past Project Information) *help	2020 – 2022: 金沢医科大学, 総合医学研究所, 講師 2014 – 2018: 金沢医科大学, 総合医学研究所, 講師 2013: 金沢医科大学, 総合医学研究所, 助教
Review Section/Research Field	Principal Investigator Cell biology / Virology / Hematology / Basic Section 48040:Medical biochemistry-related Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Integrated Nutrition Science / Prosthodontics/ Dental materials science and
Keywords	Principal Investigator スフィンゴミエリン / スフィンゴミエリン合成酵素 / スフィンゴ脂質 / 日本脳炎ウイルス / ウイルス感染 / ウイルス接着 / 脂質ラフト / 急性骨髄性白血病 / 腫瘍免疫 / 細胞障害性T細胞 … More / sphingomyelin synthase / acute myeloid leukemia / sphingomyelin / CTL / MDSC / sphingolipid / cancer progression / 血小板 / ホスファチジルセリン / スクランブラーゼ … More Except Principal Investigator スフィンゴ脂質 / スフィンゴミエリン合成酵素 / イオンチャネル / 不飽和脂肪酸 / アミロイドベータ / アルツハイマー / 電気生理 / インプラント周囲炎 / SMS2 / 癌微小環境 / 免疫細胞抑制機構 / 担癌モデル / 担癌モデルマウス / 免疫チェックポイント阻害剤 / SMS / 腫瘍免疫 / 血液腫瘍 / 固形がん Less

スフィンゴミエリン合成酵素２阻害剤による腫瘍免疫亢進を介した新規抗癌治療の開発
- Principal Investigator
  
  岡崎俊朗
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Ishikawa Prefectural University
血小板膜におけるスフィンゴミエリンを介したリン脂質露呈制御機構の解明Principal Investigator
- Principal Investigator
  
  谷口真
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kanazawa Medical University
SMS阻害による癌微小環境免疫療法の分子機構解明
- Principal Investigator
  
  橋爪智恵子
- Project Period (FY)
  2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kanazawa Medical University
Elucidation of the involvement of sphingomyelin synthase in acute myeloid leukemia progressionPrincipal Investigator
- Principal Investigator
  
  TANIGUCHI Makoto
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
  Hematology
- Research Institution
  Kanazawa Medical University
スフィンゴミエリン/脂質ラフトを標的としたインプラント周囲炎の新たな予防法の開発
- Principal Investigator
  
  呉本晃一
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Prosthodontics/ Dental materials science and
- Research Institution
  Hiroshima University
Improvement effect of Alzheimer's disease brain by the omega -3 unsaturated fatty acid through the ion channel
- Principal Investigator
  
  TAJIMA Nobuyoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Kanazawa Medical University
Role of Sphingomyelin/lipid raft on Japanese encephalitis virus infectionPrincipal Investigator
- Principal Investigator
  
  TANIGUCHI Makoto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
  Virology
- Research Institution
  Kanazawa Medical University

All 2017 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis-associated colon cancer2017
- Author(s)
  Ohnishi Toshio, Hashizume Chieko, Taniguchi Makoto, Furumoto Hidehiro, Han Jia, Gao Rongfen, Kinami Shinichi, Kosaka Takeo, Okazaki Toshiro
- Journal Title
  
  The FASEB Journal
  
  Volume: 31 Pages: 3816-3830
- DOI
  10.1096/fj.201601225rr
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K18205
[Journal Article] Stressful learning paradigm precludes manifestation of cognitive ability in sphingomyelin synthase-2 knockout mice2017
- Author(s)
  Wang Min, Uchiumi Osamu, Ogiso Hideo, Shui Yuan, Zou Jingyu, Hashizume Chieko, Taniguchi Makoto, Okazaki Toshiro, Kato Nobuo
- Journal Title
  
  Behavioural Brain Research
  
  Volume: 319 Pages: 25-30
- DOI
  10.1016/j.bbr.2016.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K18205
[Journal Article] 第8節　スフィンゴミエリン合成酵素・スフィンゴミエリナーゼ2015
- Author(s)
  谷口真，岡崎俊朗
- Journal Title
  
  疾患モデルの作製と利用　脂質代謝異常と関連疾患
  
  Volume: 下巻 Pages: 348-357
- Data Source
  KAKENHI-PROJECT-25870853
[Journal Article] Unraveling the Specific Role of Sphingomyelins in Cell Physiology: Where Are We?2015
- Author(s)
  Joan Bestard-Escalas, María Dolores Ledesma, Makoto Taniguchi, Toshiro Okazaki, María Laura Martin, and Gwendolyn Barceló-Coblijn
- Journal Title
  
  Sphingolipids: Biology, Synthesis and Functions (nova science publishers)
  
  Volume: Chapter 5 Pages: 91-128
- Data Source
  KAKENHI-PROJECT-25870853
[Journal Article] Analysis of lipid-composition changes in plasma membrane microdomains2015
- Author(s)
  Hideo Ogiso, Makoto Taniguchi, Toshiro Okazaki
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 56 Pages: 1594-1605
- DOI
  10.1194/jlr.m059972
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870853
[Journal Article] Role of sphingolipids and metabolizing enzymes in hematological malignancies2015
- Author(s)
  Kazuyuki Kitatani, Makoto Taniguchi, Toshiro Okazaki
- Journal Title
  
  Molecules and Cells
  
  Volume: 38 Pages: 482-495
- DOI
  10.14348/molcells.2015.0118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870853
[Journal Article] Role of sphingolipids in hematological malignancies: Lymphoproliferative disorders2015
- Author(s)
  Hirofumi Sawai, Makoto Taniguchi, Toshiro Okazaki
- Journal Title
  
  Bioactive Sphingolipids in Cancer Biology and Therapy (Springer)
  
  Volume: 1-1 Pages: 23-52
- DOI
  10.1007/978-3-319-20750-6_2
- Data Source
  KAKENHI-PROJECT-25870853
[Journal Article] Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis2015
- Author(s)
  Makoto Taniguchi, Hideo Ogiso, Terue Takeuchi, Kazuyuki Kitatani, Hisanori Umehara, Toshiro Okazaki
- Journal Title
  
  Cell Death & Disease
  
  Volume: 6
- DOI
  10.1038/cddis.2015.82
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25870853
[Journal Article] Comparative Analysis of Biological Sphingolipids with Glycerophospholipids and Diacylglycerol by LC-MS/MS2014
- Author(s)
  Hideo Ogiso, Makoto Taniguchi, Sinichi Araya, Shinya Aoki, Lusi Oka Wardhani, Yuka Yamashita, Yoshibumi Ueda, Toshiro Okazaki
- Journal Title
  
  Metabolites
  
  Volume: 4 Pages: 98-114
- DOI
  10.3390/metabo4010098
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25870853, KAKENHI-PROJECT-25893269
[Journal Article] スフィンゴミエリンとスフィンゴミエリン合成酵素2014
- Author(s)
  谷口真、岡崎俊朗
- Journal Title
  
  医学のあゆみ
  
  Volume: 248 Pages: 1084-1090
- Data Source
  KAKENHI-PROJECT-25870853
[Journal Article] The role of sphingomyelin and sphingomyelin synthases in cell death, proliferation and migration – from cell and animal models to human disorders-2013
- Author(s)
  Makoto Taniguchi, Toshiro Okazaki
- Journal Title
  
  Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
  
  Volume: 1841 Pages: 692-703
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870853
[Presentation] スフィンゴミエリン合成酵素2欠損マウスにおけるEL4リンパ腫浸潤抑制2017
- Author(s)
  谷口真、橋爪智恵子、上田善文、松下倫子、長屋省吾、小木曽英夫、古元秀洋、林一彦、岡崎俊朗
- Organizer
  2017年度生命科学系学会合同年次大会（第90回日本生化学会大会）
- Data Source
  KAKENHI-PROJECT-17K18205
[Presentation] スフィンゴミエリン合成酵素欠損マウス-動物病態モデルの利用と応用-2017
- Author(s)
  谷口真
- Organizer
  2017年度生命科学系学会合同年次大会（第90回日本生化学会大会）
- Data Source
  KAKENHI-PROJECT-17K18205
[Presentation] 日本脳炎ウイルス感染におけるスフィンゴミエリンの役割2015
- Author(s)
  谷口真，小木曽英夫，北川陽子，光武進，五十嵐靖之，岡崎俊朗，竹上勉
- Organizer
  第33回日本生化学会北陸支部会
- Place of Presentation
  富山大学（富山県富山市）
- Year and Date
  2015-05-23
- Invited
- Data Source
  KAKENHI-PROJECT-25870853
[Presentation] Deficiency of sphingomyelin synthase 1 prevents attachment and infection of Japanese Encephalitis Virus
- Author(s)
  Makoto Taniguchi, Hideo Ogiso, Youko Kitagawa, Kiyoe Hori, Yuka Yamashita, Shinichi Araya, Susumu Mitsutake, Yasuyuki Igarashi, Toshiro Okazaki, Tsutomu Takegami
- Organizer
  2nd International Workshop on Molecular Medicine of Sphingolipids
- Place of Presentation
  Kloster Banz Abbey Education Centre (Germany)
- Year and Date
  2014-10-12 – 2014-10-17
- Data Source
  KAKENHI-PROJECT-25870853
[Presentation] スフィンゴミエリン合成酵素1欠損による日本脳炎ウイルス接着および感染の阻害
- Author(s)
  谷口真、小木曽英夫、北川陽子、堀貴代江、山下優香、荒谷信一、光武進、五十嵐靖之、岡崎俊朗、竹上勉
- Organizer
  第62回日本ウイルス学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-25870853
[Presentation] Lysosomal ceramide generated by acid sphingomyelinase triggers cathepsin B-mediated apoptosis in IL-2-deprived natural killer cells
- Author(s)
  Makoto Taniguchi, Kazuyuki Kitatani, Yoshimitsu Taguchi, Takafumi Kawanami, Tsutomu Takegami, Hisanori Umehara, Toshiro Okazaki
- Organizer
  Gordon Research Conferences, Glycolipid & Sphingolipid Biology
- Place of Presentation
  Four Points Sheraton (USA)
- Data Source
  KAKENHI-PROJECT-25870853
[Presentation] Sphingosine-1-phosphate lessens ceramide-mediated cell death in interleukin-2 deprived natural killer cells
- Author(s)
  Makoto Taniguchi, Kazuyuki Kitatani, Yoshimitsu Taguchi, Mayumi Hashimoto, Satoshi Asano, Hiroyuki Takeya, Toshiro Okazaki
- Organizer
  2013 FASEB Science Research Conference "Lysophospholipid and Other Related Mediators - From Bench to Clinic"
- Place of Presentation
  ヒルトンニセコビレッジ（北海道）
- Data Source
  KAKENHI-PROJECT-25870853
[Presentation] 日本脳炎ウイルス接着・感染における細胞膜スフィンゴミエリンの役割
- Author(s)
  谷口真、北川陽子、堀貴代江、村上学、岡崎俊朗、竹上勉
- Organizer
  第48回日本脳炎ウイルス生態研究会
- Place of Presentation
  ニューウェルシティ湯河原（熱海）
- Data Source
  KAKENHI-PROJECT-25870853
[Presentation] 細胞膜スフィンゴミエリン減少による日本脳炎ウイルス感染阻害
- Author(s)
  谷口真、北川陽子、堀貴代江、田崎隆史、村上学、光武進、五十嵐靖之、岡崎俊朗、竹上勉
- Organizer
  第61回日本ウイルス学会
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-25870853

1. TAJIMA Nobuyoshi (30708996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 加藤伸郎 (10152729)

# of Collaborated Projects: 1 results

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3. 呉本晃一 (90319583)

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4. 土井一矢 (80444686)

# of Collaborated Projects: 1 results

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5. 橋爪智恵子 (70564128)

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6. 藤井頼孝 (20783880)

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7. 岡崎俊朗 (40233308)

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8. 村井勇太 (20707038)

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9. 門出健次 (40210207)

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10. 小木曽英夫

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Taniguchi Makoto 谷口 真

谷口 真 タニグチ マコト

TANIGUCHI Makoto 谷口 真

Research Projects

Research Products

Co-Researchers

スフィンゴミエリン合成酵素２阻害剤による腫瘍免疫亢進を介した新規抗癌治療の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

血小板膜におけるスフィンゴミエリンを介したリン脂質露呈制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

SMS阻害による癌微小環境免疫療法の分子機構解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the involvement of sphingomyelin synthase in acute myeloid leukemia progressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

スフィンゴミエリン/脂質ラフトを標的としたインプラント周囲炎の新たな予防法の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Improvement effect of Alzheimer's disease brain by the omega -3 unsaturated fatty acid through the ion channel

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of Sphingomyelin/lipid raft on Japanese encephalitis virus infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis-associated colon cancer2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stressful learning paradigm precludes manifestation of cognitive ability in sphingomyelin synthase-2 knockout mice2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 第8節 スフィンゴミエリン合成酵素・スフィンゴミエリナーゼ2015

Author(s)

Journal Title

Data Source

[Journal Article] Unraveling the Specific Role of Sphingomyelins in Cell Physiology: Where Are We?2015

Author(s)

Journal Title

Data Source

[Journal Article] Analysis of lipid-composition changes in plasma membrane microdomains2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of sphingolipids and metabolizing enzymes in hematological malignancies2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of sphingolipids in hematological malignancies: Lymphoproliferative disorders2015

Author(s)

Journal Title

DOI

Taniguchi Makoto 谷口真

谷口真タニグチマコト

TANIGUCHI Makoto 谷口真

[Journal Article] 第8節　スフィンゴミエリン合成酵素・スフィンゴミエリナーゼ2015