Taniguchi Makoto 谷口真

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TANIGUCHI Makoto 谷口真

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Researcher Number	30529433
Other IDs
Affiliation (Current)	2025: 金沢医科大学, 総合医学研究所, 講師
Affiliation (based on the past Project Information) *help	2020 – 2025: 金沢医科大学, 総合医学研究所, 講師 2014 – 2018: 金沢医科大学, 総合医学研究所, 講師 2013: 金沢医科大学, 総合医学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 38030:Applied biochemistry-related / Basic Section 48040:Medical biochemistry-related / Hematology / Virology Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 56050:Otorhinolaryngology-related / Prosthodontics/ Dental materials science and / Integrated Nutrition Science
Keywords	Principal Investigator スフィンゴミエリン合成酵素 / スフィンゴミエリン / スフィンゴ脂質 / オートファゴソーム / オートファジー / セラミド / カルシウム / TMEM16F / スクランブラーゼ / ホスファチジルセリン … More / 血小板減少症 / 血小板 / cancer progression / sphingolipid / MDSC / CTL / sphingomyelin / acute myeloid leukemia / sphingomyelin synthase / 細胞障害性T細胞 / 腫瘍免疫 / 急性骨髄性白血病 / 脂質ラフト / ウイルス接着 / ウイルス感染 / 日本脳炎ウイルス … More Except Principal Investigator スフィンゴミエリン合成酵素 / スフィンゴ脂質 / 遺伝子発現 / 嗅覚中枢 / モデルマウス / アルツハイマー病 / 嗅覚奪取 / 固形がん / 血液腫瘍 / 阻害剤 / スフィンゴミエリン合成酵素２ / 腫瘍免疫 / スフィンゴミエリン / セラミド / SMS / 免疫チェックポイント阻害剤 / 担癌モデルマウス / 担癌モデル / 免疫細胞抑制機構 / 癌微小環境 / SMS2 / インプラント周囲炎 / 電気生理 / アルツハイマー / アミロイドベータ / 不飽和脂肪酸 / イオンチャネル Less

嗅覚ロスによるアルツハイマー病の増悪メカニズム
- Principal Investigator
  
  加藤伸郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Kanazawa Medical University
オートファゴソーム膜におけるセラミド/SMサイクルを介した細胞運命決定機構の解明Principal Investigator
- Principal Investigator
  
  谷口真
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Kanazawa Medical University
スフィンゴミエリン合成酵素２阻害剤による腫瘍免疫亢進を介した新規抗癌治療の開発
- Principal Investigator
  
  岡崎俊朗
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Ishikawa Prefectural University
  Kanazawa University
血小板膜におけるスフィンゴミエリンを介したリン脂質露呈制御機構の解明Principal Investigator
- Principal Investigator
  
  谷口真
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kanazawa Medical University
SMS阻害による癌微小環境免疫療法の分子機構解明
- Principal Investigator
  
  橋爪智恵子
- Project Period (FY)
  2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kanazawa Medical University
Elucidation of the involvement of sphingomyelin synthase in acute myeloid leukemia progressionPrincipal Investigator
- Principal Investigator
  
  TANIGUCHI Makoto
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa Medical University
スフィンゴミエリン/脂質ラフトを標的としたインプラント周囲炎の新たな予防法の開発
- Principal Investigator
  
  呉本晃一
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Prosthodontics/ Dental materials science and
- Research Institution
  Hiroshima University
Improvement effect of Alzheimer's disease brain by the omega -3 unsaturated fatty acid through the ion channel
- Principal Investigator
  
  TAJIMA Nobuyoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Kanazawa Medical University
Role of Sphingomyelin/lipid raft on Japanese encephalitis virus infectionPrincipal Investigator
- Principal Investigator
  
  TANIGUCHI Makoto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Kanazawa Medical University

All 2024 2023 2022 2021 2017 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Ceramide Metabolism Regulated by Sphingomyelin Synthase 2 Is Associated with Acquisition of Chemoresistance via Exosomes in Human Leukemia Cells2022
- Author(s)
  Taniguchi Makoto、Nagaya Shingo、Yuyama Kohei、Kotani Ai、Igarashi Yasuyuki、Okazaki Toshiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 18 Pages: 10648-10648
- DOI
  10.3390/ijms231810648
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06827
[Journal Article] Nuclear Ceramide Is Associated with Ataxia Telangiectasia Mutated Activation in the Neocarzinostatin-Induced Apoptosis of Lymphoblastoid Cells2022
- Author(s)
  Fujita Jun、Taniguchi Makoto、Hashizume Chieko、Ueda Yoshibumi、Sakai Shota、Kondo Tadakazu、Hashimoto-Nishimura Mayumi、Hanada Kentaro、Kosaka Takeo、Okazaki Toshiro
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 101 Issue: 5 Pages: 322-333
- DOI
  10.1124/molpharm.121.000379
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07685, KAKENHI-PROJECT-21K06827
[Journal Article] Role of ceramide/sphingomyelin (SM) balance regulated through “SM cycle” in cancer2021
- Author(s)
  Taniguchi Makoto、Okazaki Toshiro
- Journal Title
  
  Cellular Signalling
  
  Volume: 87 Pages: 110119-110119
- DOI
  10.1016/j.cellsig.2021.110119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06827
[Journal Article] A novel mechanism of thrombocytopenia by PS exposure through TMEM16F in sphingomyelin synthase 1 deficiency2021
- Author(s)
  Fujii Yoritaka、Taniguchi Makoto、Nagaya Shingo、Ueda Yoshibumi、Hashizume Chieko、Watanabe Ken、Takeya Hiroyuki、Kosaka Takeo、Okazaki Toshiro
- Journal Title
  
  Blood Advances
  
  Volume: 5 Issue: 20 Pages: 4265-4277
- DOI
  10.1182/bloodadvances.2020002922
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07685, KAKENHI-PROJECT-21K06827
[Journal Article] Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis-associated colon cancer2017
- Author(s)
  Ohnishi Toshio, Hashizume Chieko, Taniguchi Makoto, Furumoto Hidehiro, Han Jia, Gao Rongfen, Kinami Shinichi, Kosaka Takeo, Okazaki Toshiro
- Journal Title
  
  The FASEB Journal
  
  Volume: 31 Issue: 9 Pages: 3816-3830
- DOI
  10.1096/fj.201601225rr
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K18205
[Journal Article] Stressful learning paradigm precludes manifestation of cognitive ability in sphingomyelin synthase-2 knockout mice2017
- Author(s)
  Wang Min, Uchiumi Osamu, Ogiso Hideo, Shui Yuan, Zou Jingyu, Hashizume Chieko, Taniguchi Makoto, Okazaki Toshiro, Kato Nobuo
- Journal Title
  
  Behavioural Brain Research
  
  Volume: 319 Pages: 25-30
- DOI
  10.1016/j.bbr.2016.11.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K18205
[Journal Article] 第8節　スフィンゴミエリン合成酵素・スフィンゴミエリナーゼ2015
- Author(s)
  谷口真，岡崎俊朗
- Journal Title
  
  疾患モデルの作製と利用　脂質代謝異常と関連疾患
  
  Volume: 下巻 Pages: 348-357
- Data Source
  KAKENHI-PROJECT-25870853
[Journal Article] Unraveling the Specific Role of Sphingomyelins in Cell Physiology: Where Are We?2015
- Author(s)
  Joan Bestard-Escalas, María Dolores Ledesma, Makoto Taniguchi, Toshiro Okazaki, María Laura Martin, and Gwendolyn Barceló-Coblijn
- Journal Title
  
  Sphingolipids: Biology, Synthesis and Functions (nova science publishers)
  
  Volume: Chapter 5 Pages: 91-128
- Data Source
  KAKENHI-PROJECT-25870853
[Journal Article] Analysis of lipid-composition changes in plasma membrane microdomains2015
- Author(s)
  Hideo Ogiso, Makoto Taniguchi, Toshiro Okazaki
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 56 Issue: 8 Pages: 1594-1605
- DOI
  10.1194/jlr.m059972
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870853
[Journal Article] Role of sphingolipids and metabolizing enzymes in hematological malignancies2015
- Author(s)
  Kazuyuki Kitatani, Makoto Taniguchi, Toshiro Okazaki
- Journal Title
  
  Molecules and Cells
  
  Volume: 38 Issue: 6 Pages: 482-495
- DOI
  10.14348/molcells.2015.0118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870853
[Journal Article] Role of sphingolipids in hematological malignancies: Lymphoproliferative disorders2015
- Author(s)
  Hirofumi Sawai, Makoto Taniguchi, Toshiro Okazaki
- Journal Title
  
  Bioactive Sphingolipids in Cancer Biology and Therapy (Springer)
  
  Volume: 1-1 Pages: 23-52
- DOI
  10.1007/978-3-319-20750-6_2
- ISBN
  9783319207490, 9783319207506
- Data Source
  KAKENHI-PROJECT-25870853
[Journal Article] Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis2015
- Author(s)
  Makoto Taniguchi, Hideo Ogiso, Terue Takeuchi, Kazuyuki Kitatani, Hisanori Umehara, Toshiro Okazaki
- Journal Title
  
  Cell Death & Disease
  
  Volume: 6 Issue: 4 Pages: e1717-e1717
- DOI
  10.1038/cddis.2015.82
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25870853
[Journal Article] Comparative analysis of biological sphingolipids with glycerophospholipids and diacylglycerol by LC-MS/MS2014
- Author(s)
  Hideo Ogiso, Makoto Taniguchi, Sinichi Araya, Shinya Aoki, Lusi Oka Wardhani, Yuka Yamashita, Yoshibumi Ueda, Toshiro Okazaki
- Journal Title
  
  Metabolites
  
  Volume: 4 Issue: 1 Pages: 98-114
- DOI
  10.3390/metabo4010098
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25870853, KAKENHI-PROJECT-25893269
[Journal Article] スフィンゴミエリンとスフィンゴミエリン合成酵素2014
- Author(s)
  谷口真、岡崎俊朗
- Journal Title
  
  医学のあゆみ
  
  Volume: 248 Pages: 1084-1090
- Data Source
  KAKENHI-PROJECT-25870853
[Journal Article] The role of sphingomyelin and sphingomyelin synthases in cell death, proliferation and migration – from cell and animal models to human disorders-2013
- Author(s)
  Makoto Taniguchi, Toshiro Okazaki
- Journal Title
  
  Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
  
  Volume: 1841 Pages: 692-703
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870853
[Presentation] スフィンゴミエリン合成酵素KOマウスを利用した疾患モデルの確立と病態機序解明2024
- Author(s)
  谷口真
- Organizer
  ビタミンB研究委員会 2023年度シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K06827
[Presentation] がん細胞およびマウスがんモデルを用いたスフィンゴミエリン合成酵素阻害剤の開発と現状2023
- Author(s)
  谷口真、村井勇太、門出健次、岡崎俊朗
- Organizer
  第16回セラミド研究会・第17回スフィンゴテラピィ研究会合同年会
- Data Source
  KAKENHI-PROJECT-21K06827
[Presentation] 白血病細胞におけるスフィンゴミエリン合成酵素2によるセラミド代謝を介したエクソソーム放出促進と抗がん剤耐性能獲得について2022
- Author(s)
  谷口真，長屋進吾，湯山耕平，幸谷愛，五十嵐靖之，岡崎俊朗
- Organizer
  第15回セラミド研究会・第16回スフィンゴテラピィ研究会合同年会
- Data Source
  KAKENHI-PROJECT-21K06827
[Presentation] 喘息病態形成へのスフィンゴミエリン合成酵素2の関与2022
- Author(s)
  榮春海，小木曽悠里，藤原拓海，渡邉研，岡崎俊朗，谷口真，松田将也，奈邉健，北谷和之
- Organizer
  第15回セラミド研究会・第16回スフィンゴテラピィ研究会合同年会
- Data Source
  KAKENHI-PROJECT-21K06827
[Presentation] スフィンゴミエリン合成酵素2欠損マウスにおけるEL4リンパ腫浸潤抑制2017
- Author(s)
  谷口真、橋爪智恵子、上田善文、松下倫子、長屋省吾、小木曽英夫、古元秀洋、林一彦、岡崎俊朗
- Organizer
  2017年度生命科学系学会合同年次大会（第90回日本生化学会大会）
- Data Source
  KAKENHI-PROJECT-17K18205
[Presentation] スフィンゴミエリン合成酵素欠損マウス-動物病態モデルの利用と応用-2017
- Author(s)
  谷口真
- Organizer
  2017年度生命科学系学会合同年次大会（第90回日本生化学会大会）
- Data Source
  KAKENHI-PROJECT-17K18205
[Presentation] 日本脳炎ウイルス感染におけるスフィンゴミエリンの役割2015
- Author(s)
  谷口真，小木曽英夫，北川陽子，光武進，五十嵐靖之，岡崎俊朗，竹上勉
- Organizer
  第33回日本生化学会北陸支部会
- Place of Presentation
  富山大学（富山県富山市）
- Year and Date
  2015-05-23
- Invited
- Data Source
  KAKENHI-PROJECT-25870853
[Presentation] Deficiency of sphingomyelin synthase 1 prevents attachment and infection of Japanese Encephalitis Virus
- Author(s)
  Makoto Taniguchi, Hideo Ogiso, Youko Kitagawa, Kiyoe Hori, Yuka Yamashita, Shinichi Araya, Susumu Mitsutake, Yasuyuki Igarashi, Toshiro Okazaki, Tsutomu Takegami
- Organizer
  2nd International Workshop on Molecular Medicine of Sphingolipids
- Place of Presentation
  Kloster Banz Abbey Education Centre (Germany)
- Year and Date
  2014-10-12 – 2014-10-17
- Data Source
  KAKENHI-PROJECT-25870853
[Presentation] スフィンゴミエリン合成酵素1欠損による日本脳炎ウイルス接着および感染の阻害
- Author(s)
  谷口真、小木曽英夫、北川陽子、堀貴代江、山下優香、荒谷信一、光武進、五十嵐靖之、岡崎俊朗、竹上勉
- Organizer
  第62回日本ウイルス学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-25870853
[Presentation] Lysosomal ceramide generated by acid sphingomyelinase triggers cathepsin B-mediated apoptosis in IL-2-deprived natural killer cells
- Author(s)
  Makoto Taniguchi, Kazuyuki Kitatani, Yoshimitsu Taguchi, Takafumi Kawanami, Tsutomu Takegami, Hisanori Umehara, Toshiro Okazaki
- Organizer
  Gordon Research Conferences, Glycolipid & Sphingolipid Biology
- Place of Presentation
  Four Points Sheraton (USA)
- Data Source
  KAKENHI-PROJECT-25870853
[Presentation] Sphingosine-1-phosphate lessens ceramide-mediated cell death in interleukin-2 deprived natural killer cells
- Author(s)
  Makoto Taniguchi, Kazuyuki Kitatani, Yoshimitsu Taguchi, Mayumi Hashimoto, Satoshi Asano, Hiroyuki Takeya, Toshiro Okazaki
- Organizer
  2013 FASEB Science Research Conference "Lysophospholipid and Other Related Mediators - From Bench to Clinic"
- Place of Presentation
  ヒルトンニセコビレッジ（北海道）
- Data Source
  KAKENHI-PROJECT-25870853
[Presentation] 日本脳炎ウイルス接着・感染における細胞膜スフィンゴミエリンの役割
- Author(s)
  谷口真、北川陽子、堀貴代江、村上学、岡崎俊朗、竹上勉
- Organizer
  第48回日本脳炎ウイルス生態研究会
- Place of Presentation
  ニューウェルシティ湯河原（熱海）
- Data Source
  KAKENHI-PROJECT-25870853
[Presentation] 細胞膜スフィンゴミエリン減少による日本脳炎ウイルス感染阻害
- Author(s)
  谷口真、北川陽子、堀貴代江、田崎隆史、村上学、光武進、五十嵐靖之、岡崎俊朗、竹上勉
- Organizer
  第61回日本ウイルス学会
- Place of Presentation
  神戸国際会議場（神戸）
- Data Source
  KAKENHI-PROJECT-25870853

1. 加藤伸郎 (10152729)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. TAJIMA Nobuyoshi (30708996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 呉本晃一 (90319583)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 土井一矢 (80444686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 橋爪智恵子 (70564128)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 藤井頼孝 (20783880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 岡崎俊朗 (40233308)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 村井勇太 (20707038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 門出健次 (40210207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 三輪高喜 (20229909)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 小野宗範 (30422942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 山本亮 (30447974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. UEDA Yoshibumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Taniguchi Makoto 谷口 真

TANIGUCHI Makoto 谷口 真

Research Projects

Research Products

Co-Researchers

嗅覚ロスによるアルツハイマー病の増悪メカニズム

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

オートファゴソーム膜におけるセラミド/SMサイクルを介した細胞運命決定機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

スフィンゴミエリン合成酵素２阻害剤による腫瘍免疫亢進を介した新規抗癌治療の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

血小板膜におけるスフィンゴミエリンを介したリン脂質露呈制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

SMS阻害による癌微小環境免疫療法の分子機構解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the involvement of sphingomyelin synthase in acute myeloid leukemia progressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

スフィンゴミエリン/脂質ラフトを標的としたインプラント周囲炎の新たな予防法の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Improvement effect of Alzheimer's disease brain by the omega -3 unsaturated fatty acid through the ion channel

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of Sphingomyelin/lipid raft on Japanese encephalitis virus infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Ceramide Metabolism Regulated by Sphingomyelin Synthase 2 Is Associated with Acquisition of Chemoresistance via Exosomes in Human Leukemia Cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nuclear Ceramide Is Associated with Ataxia Telangiectasia Mutated Activation in the Neocarzinostatin-Induced Apoptosis of Lymphoblastoid Cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of ceramide/sphingomyelin (SM) balance regulated through “SM cycle” in cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel mechanism of thrombocytopenia by PS exposure through TMEM16F in sphingomyelin synthase 1 deficiency2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis-associated colon cancer2017

Taniguchi Makoto 谷口真

TANIGUCHI Makoto 谷口真

[Journal Article] 第8節　スフィンゴミエリン合成酵素・スフィンゴミエリナーゼ2015