Ito Takumi 伊藤拓水

… Alternative Names

ITO Takumi 伊藤拓水

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Researcher Number	30533179
Other IDs	https://orcid.org/0000-0002-9997-2664
Affiliation (Current)	2023: 東京医科大学, 医学部, 客員准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 東京医科大学, 医学部, 客員准教授 2016 – 2022: 東京医科大学, 医学部, 准教授 2013 – 2015: 東京医科大学, 医学部, 講師 2012: 東京工業大学, 生命理工学研究科, 特任助教 2011: 東京工業大学, ソリューション研究機構, ソリューション研究員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology / Chemical biology / Chemical biology Except Principal Investigator Transformative Research Areas, Section (III) / Complex systems
Keywords	Principal Investigator IMiDs / ユビキチン / セレブロン / サリドマイド / CRBN / PROTACs / ポマリドミド / ユビキチンリガーゼ / ケミカルバイオロジー / 多発性骨髄腫 … More / ケミカルジェネティクス / 骨髄腫 / タンパク質分解 / ネオ基質 / 急性骨髄性白血病 / レナリドミド / CC-885 / GSPT1 / レナリドマイド / ポマリドマイド / E3 / 催奇性 … More Except Principal Investigator PROTAC / E3アダプタータンパク質 / アプタマー / CRBNモジュレーター / ペプチド / IAP / プロテアソーム / 脱ユビキチン化酵素 / 血管新生 / セレブロン / サリドマイド / デコイ核酸 / ステープルペプチド / タンパク質分解 / ユビキチン / セレブロンモジュレーター / SNIPER / ケミカルプロテインノックダウン Less

Controlling the lifetime of proteins using chemical degraders
- Principal Investigator
  
  出水庸介
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  National Institute of Health Sciences
Elucidation of the therapeutic mechanisms of IMiDsPrincipal Investigator
- Principal Investigator
  
  伊藤拓水
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokyo Medical University
Chemical protein knockdown technology and cell regulation
- Principal Investigator
  
  内藤幹彦
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
  National Institute of Health Sciences
Elucidation of the molecular basis of IMiDs' actionPrincipal Investigator
- Principal Investigator
  
  Ito Takumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical University
Elucidation of the molecular mechanism of the anti-cancer activity of IMiDsPrincipal Investigator
- Principal Investigator
  
  Ito Takumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  Tokyo Medical University
Analysis of thalidomide induced CRBN-E3-ubiquitin-ligase inhibition mechanismPrincipal Investigator
- Principal Investigator
  
  ITO Takumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  Tokyo Medical University
  Tokyo Institute of Technology

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book Patent

[Book] "Chapter 16， Protein degradation inducers SNIPERs and PROTACs against oncogenic proteins, In Pharmaceutical Biocatalysis Fundamentals, Enzyme Inhibitors, and Enzymes in Health and Diseases"2019
- Author(s)
  Shibata N, Ohoka N, Hattori T, Naito M.
- Total Pages
  20
- Publisher
  Jenny Stanford Publishing
- ISBN
  9789814800617
- Data Source
  KAKENHI-PLANNED-18H05502
[Book] Development of a new affinity nanobead technology and target isolatioin of bioactive compounds2018
- Author(s)
  Takumi Ito, Mamoru Hatakeyama, Hiroshi Handa
- Total Pages
  27
- Publisher
  IOP Publishing Ltd
- ISBN
- Data Source
  KAKENHI-PLANNED-18H05502
[Book] IMiDs（免疫調整薬）の現状と展望2015
- Author(s)
  伊藤拓水、安藤秀樹、半田宏
- Total Pages
  233
- Publisher
  （株）メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-26750374
[Book] 日本臨牀（特集：多発性骨髄腫の病態と最新治療―基礎と臨床の最新情報ー2015
- Author(s)
  伊藤拓水、安藤秀樹、半田宏
- Total Pages
  182
- Publisher
  （株）日本臨牀社
- Data Source
  KAKENHI-PROJECT-26750374
[Book] 生物活性分子の標的同定と機能解明（CSJカレントビュー第19号）2015
- Author(s)
  坂本聡、伊藤拓水、半田宏
- Total Pages
  189
- Publisher
  （株）化学同人
- Data Source
  KAKENHI-PROJECT-26750374
[Book] Organ Biology 21巻２号2014
- Author(s)
  伊藤拓水、安藤秀樹、半田宏
- Total Pages
  273
- Publisher
  （株）日本医学館
- Data Source
  KAKENHI-PROJECT-26750374
[Journal Article] Molecular Design, Synthesis, and Evaluation of SNIPER (ER) that Induces Targeted Protein Degradation of ERα2022
- Author(s)
  Ohoka N, Yokoo H, Okuhira K, Demizu Y, Naito M.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 2418 Pages: 363-382
- DOI
  10.1007/978-1-0716-1920-9_20
- ISBN
  9781071619193, 9781071619209
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K06490
[Journal Article] Development of a degrader against oncogenic fusion protein FGFR3-TACC32022
- Author(s)
  Shibata Norihito、Cho Nobuo、Koyama Hiroo、Naito Mikihiko
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 60 Pages: 128584-128584
- DOI
  10.1016/j.bmcl.2022.128584
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07311, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K06075
[Journal Article] Targeting CRABP-II overcomes pancreatic cancer drug resistance by reversing lipid raft cholesterol accumulation and AKT survival signaling2022
- Author(s)
  Yu Shuiliang、Wang Lei、Che Danian、Zhang Mei、Li Ming、Naito Mikihiko、Xin Wei、Zhou Lan
- Journal Title
  
  Journal of Experimental & Clinical Cancer Research
  
  Volume: 41 Issue: 1 Pages: 88-88
- DOI
  10.1186/s13046-022-02261-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
[Journal Article] Hybrid molecule between platanic acid and LCL-161 as a yes-associated protein degrader2022
- Author(s)
  Nakano Naoko、Fukuda Kazuo、Tashiro Etsu、Ishikawa Haruka、Nagano Waka、Kawamoto Rie、Mori Alice、Watanabe Misao、Yamazaki Ryu、Nakane Takahisa、Naito Mikihiko、Okamoto Iwao、Itoh Susumu
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 171 Issue: 6 Pages: 1-10
- DOI
  10.1093/jb/mvac021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K06975
[Journal Article] PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates2021
- Author(s)
  Shimizu Nobuyuki、Asatsuma-Okumura Tomoko、Yamamoto Junichi、Yamaguchi Yuki、Handa Hiroshi、Ito Takumi
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 1277-1277
- DOI
  10.1038/s42003-021-02801-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16314, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-20H03182, KAKENHI-PROJECT-21H02955
[Journal Article] Peptide Stapling Improves the Sustainability of a Peptide-Based Chimeric Molecule That Induces Targeted Protein Degradation2021
- Author(s)
  Yokoo Hidetomo、Ohoka Nobumichi、Takyo Mami、Ito Takahito、Tsuchiya Keisuke、Kurohara Takashi、Fukuhara Kiyoshi、Inoue Takao、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 16 Pages: 8772-8772
- DOI
  10.3390/ijms22168772
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-20K22711
[Journal Article] Development of Chimeric Molecules That Degrade the Estrogen Receptor Using Decoy Oligonucleotide Ligands2021
- Author(s)
  Naganuma M, Ohoka N, Tsuji G, Tsujimura H, Matsuno K, Inoue T, Naito M, Demizu Y.
- Journal Title
  
  ACS Med Chem Lett.
  
  Volume: 13 Issue: 1 Pages: 134-139
- DOI
  10.1021/acsmedchemlett.1c00629
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-22KJ2565
[Journal Article] Development of Agonist-Based PROTACs Targeting Liver X Receptor2021
- Author(s)
  Xu Hanqiao、Ohoka Nobumichi、Yokoo Hidetomo、Nemoto Kanako、Ohtsuki Takashi、Matsufuji Hiroshi、Naito Mikihiko、Inoue Takao、Tsuji Genichiro、Demizu Yosuke
- Journal Title
  
  Frontiers in Chemistry
  
  Volume: 9 Pages: 674967-674967
- DOI
  10.3389/fchem.2021.674967
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K05320
[Journal Article] TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains2021
- Author(s)
  Kaiho-Soma Ai、Akizuki Yoshino、Igarashi Katsuhide、Endo Akinori、Shoda Takuji、Kawase Yasuko、Demizu Yosuke、Naito Mikihiko、Saeki Yasushi、Tanaka Keiji、Ohtake Fumiaki
- Journal Title
  
  Molecular Cell
  
  Volume: 81 Issue: 7 Pages: 1411-1424.e7
- DOI
  10.1016/j.molcel.2021.01.023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07009, KAKENHI-PROJECT-17H01882, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-20K22726, KAKENHI-PROJECT-17H03986, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-21H03604, KAKENHI-PROJECT-21K05320
[Journal Article] Protocols for Synthesis of and the Methods to Evaluate the Anticancer Effects2021
- Author(s)
  Tsukumo Yoshinori、Tsuji Genichiro、Yokoo Hidetomo、Shibata Norihito、Ohoka Nobumichi、Demizu Yosuke、Naito Mikihiko
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: 2365 Pages: 331-347
- DOI
  10.1007/978-1-0716-1665-9_18
- ISBN
  9781071616642, 9781071616659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K07311, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-19K07724, KAKENHI-PROJECT-21K05320
[Journal Article] Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology2021
- Author(s)
  Ito Takumi、Yamaguchi Yuki、Handa Hiroshi
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 28 Issue: 7 Pages: 987-999
- DOI
  10.1016/j.chembiol.2021.04.012
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-20H03182
[Journal Article] Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer2021
- Author(s)
  Yokoo Hidetomo、Shibata Norihito、Naganuma Miyako、Murakami Yuki、Fujii Kiyonaga、Ito Takahito、Aritake Kosuke、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 12 Issue: 2 Pages: 236-241
- DOI
  10.1021/acsmedchemlett.0c00605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07311, KAKENHI-PROJECT-20K22711, KAKENHI-PROJECT-17K08385, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K05320
[Journal Article] Gluing Proteins for Targeted Degradation2021
- Author(s)
  Naito Mikihiko、Murata Shigeo
- Journal Title
  
  Cancer Cell
  
  Volume: 39 Issue: 1 Pages: 19-21
- DOI
  10.1016/j.ccell.2020.12.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05502, KAKENHI-ORGANIZER-18H05497
[Journal Article] Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine2021
- Author(s)
  Tomomi Sato, Takumi Ito and Hiroshi Handa
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 9 Pages: 1-9
- DOI
  10.3389/fcell.2021.629326
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09271, KAKENHI-PLANNED-18H05502
[Journal Article] Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design2021
- Author(s)
  Yokoo Hidetomo、Shibata Norihito、Endo Akinori、Ito Takahito、Yanase Yuta、Murakami Yuki、Fujii Kiyonaga、Hamamura Kengo、Saeki Yasushi、Naito Mikihiko、Aritake Kosuke、Demizu Yosuke
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 64 Issue: 21 Pages: 15868-15882
- DOI
  10.1021/acs.jmedchem.1c01206
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K07311, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-20K06568, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K11613, KAKENHI-PROJECT-20K22711
[Journal Article] Intermolecular interaction-based ubiquitin-proteasome system-targeting drug discovery2021
- Author(s)
  Naito Mikihiko、Komatsu Hirotsugu
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 156 Issue: 1 Pages: 9-12
- DOI
  10.1254/fpj.20070
- NAID
  130007965017
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777
[Journal Article] Molecular Glue Degrader2021
- Author(s)
  伊藤拓水、朝妻知子、半田宏
- Journal Title
  
  細胞
  
  Volume: 53 Pages: 140-143
- NAID
  40022519984
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence2021
- Author(s)
  Hirano Motoharu、Saito Chihiro、Yokoo Hidetomo、Goto Chihiro、Kawano Ryuji、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 2 Pages: 444-444
- DOI
  10.3390/molecules26020444
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18K14880, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Critical role of mitochondrial ubiquitination and the OPTN?ATG9A axis in mitophagy2020
- Author(s)
  Yamano Koji、Kikuchi Reika、Kojima Waka、Hayashida Ryota、Koyano Fumika、Kawawaki Junko、Shoda Takuji、Demizu Yosuke、Naito Mikihiko、Tanaka Keiji、Matsuda Noriyuki
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 219 Issue: 9 Pages: 1-23
- DOI
  10.1083/jcb.201912144
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K07009, KAKENHI-PLANNED-18H05500, KAKENHI-PLANNED-18H05502, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K06237
[Journal Article] Molecular Mechanisms of the Teratogenic Effects of Thalidomide2020
- Author(s)
  Asatsuma-Okumura Tomoko、Ito Takumi、Handa Hiroshi
- Journal Title
  
  Pharmaceuticals
  
  Volume: 13 Issue: 5 Pages: 95-95
- DOI
  10.3390/ph13050095
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] Design and synthesis of peptide-based chimeric molecules to induce degradation of the estrogen and androgen receptors2020
- Author(s)
  Yokoo Hidetomo、Ohoka Nobumichi、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 28 Issue: 15 Pages: 115595-115595
- DOI
  10.1016/j.bmc.2020.115595
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-PLANNED-18H05502
[Journal Article] Molecular mechanisms of thalidomide and its derivatives2020
- Author(s)
  ITO Takumi、HANDA Hiroshi
- Journal Title
  
  Proceedings of the Japan Academy, Series B
  
  Volume: 96 Issue: 6 Pages: 189-203
- DOI
  10.2183/pjab.96.016
- NAID
  130007853739
- ISSN
  0386-2208, 1349-2896
- Year and Date
  2020-06-11
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] サリドマイドの作用機序とセレブロンモジュレーター2020
- Author(s)
  伊藤拓水、半田宏
- Journal Title
  
  実験医学
  
  Volume: 38 Pages: 2310-2314
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells2020
- Author(s)
  Shibata Norihito、Ohoka Nobumichi、Tsuji Genichiro、Demizu Yosuke、Miyawaza Keiji、Ui-Tei Kumiko、Akiyama Tetsu、Naito Mikihiko
- Journal Title
  
  Oncogene
  
  Volume: - Issue: 19 Pages: 3867-3878
- DOI
  10.1038/s41388-020-1253-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07311, KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-17H01537, KAKENHI-PROJECT-17K08385, KAKENHI-PLANNED-18H05502
[Journal Article] Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs2020
- Author(s)
  Ishikawa Minoru、Tomoshige Shusuke、Demizu Yosuke、Naito Mikihiko
- Journal Title
  
  Pharmaceuticals
  
  Volume: 13 Issue: 4 Pages: 74-74
- DOI
  10.3390/ph13040074
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K16326, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18H02551
[Journal Article] ARID2 is a pomalidomide-dependent CRL4 CRBN substrate in multiple myeloma cells2020
- Author(s)
  Yamamoto J, Suwa T, Murase Y, Tateno S, Mizutome H, Asatsuma-Okumura T, Shimizu N, Kishi T, Momose S, Kizaki M, Ito T, Yamaguchi Y, Handa H.
- Journal Title
  
  Nat Chem Biol
  
  Volume: 16 Issue: 11 Pages: 1208-1217
- DOI
  10.1038/s41589-020-0645-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07396, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-20H03182, KAKENHI-PROJECT-19K16378
[Journal Article] Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide2020
- Author(s)
  Tateno Shumpei、Iida Midori、Fujii Satoshi、Suwa Tetsufumi、Katayama Miki、Tokuyama Haruka、Yamamoto Junichi、Ito Takumi、Sakamoto Satoshi、Handa Hiroshi、Yamaguchi Yuki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 4012-4012
- DOI
  10.1038/s41598-020-61027-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-17H06112, KAKENHI-PROJECT-17H04213, KAKENHI-PROJECT-20H03182
[Journal Article] Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety.2020
- Author(s)
  Shoda T, Ohoka N, Tsuji G, Fujisato T, Inoue H, Demizu Y, Naito M, Kurihara M.
- Journal Title
  
  Pharmaceuticals (Basel).
  
  Volume: 13 Issue: 3 Pages: 34-34
- DOI
  10.3390/ph13030034
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07009, KAKENHI-PLANNED-18H05502
[Journal Article] SNIPERs - Hijacking IAP activity to induce protein degradation.2019
- Author(s)
  Naito M, Ohoka N, Shibata N.
- Journal Title
  
  Drug Discovery Today: Technology
  
  Volume: 印刷中 Pages: 481-488
- DOI
  10.1016/j.ddtec.2018.12.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-18K06567, KAKENHI-PLANNED-18H05502
[Journal Article] p63 is a cereblon substrate involved in thalidomide teratogenicity2019
- Author(s)
  Asatsuma-Okumura Tomoko、Ando Hideki、De Simone Marco、Yamamoto Junichi、Sato Tomomi、Shimizu Nobuyuki、Asakawa Kazuhide、Yamaguchi Yuki、Ito Takumi、Guerrini Luisa、Handa Hiroshi
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 15 Issue: 11 Pages: 1077-1084
- DOI
  10.1038/s41589-019-0366-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-17H06112, KAKENHI-PROJECT-15H04288, KAKENHI-PROJECT-17H04213
[Journal Article] Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER)2019
- Author(s)
  Ohoka Nobumichi、Ujikawa Osamu、Shimokawa Kenichiro、Sameshima Tomoya、Shibata Norihito、Hattori Takayuki、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 67 Issue: 3 Pages: 203-209
- DOI
  10.1248/cpb.c18-00567
- NAID
  130007607114
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2019-03-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues2019
- Author(s)
  Misawa T, Goto C, Shibata N, Hirano M, Kikuchi Y, Naito M, Demizu Y
- Journal Title
  
  Med Chem Comm
  
  Volume: 印刷中 Issue: 6 Pages: 896-900
- DOI
  10.1039/c9md00166b
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-17K08385
[Journal Article] Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation2019
- Author(s)
  Hideki Ando, Tomomi Sato, Takumi Ito, Junichi Yamamoto, Satoshi Sakamoto, Nobuhiro Nitta, Tomoko Asatsuma-Okumura, Nobuyuki Shimizu, Ryota Mizushima, Ichio Aoki, Takeshi Imai, Yuki Yamaguchi, Arnold J Berk, and Hiroshi Handa
- Journal Title
  
  iScience
  
  Volume: 15 Pages: 95-108
- DOI
  10.1016/j.isci.2019.04.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09271, KAKENHI-PROJECT-17H06112, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-17H04213
[Journal Article] Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs.2019
- Author(s)
  Naito M, Ohoka N, Shibata N, Tsukumo Y.
- Journal Title
  
  Front Chem.
  
  Volume: 7 Pages: 849-849
- DOI
  10.3389/fchem.2019.00849
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07724, KAKENHI-PLANNED-18H05502
[Journal Article] Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating peptide foldamers for efficient siRNA delivery2019
- Author(s)
  T. Misawa,* N. Ohoka,* M. Oba, H. Yamashita, M. Tanaka, M. Naito, Y. Demizu*
- Journal Title
  
  Chem. Commun.
  
  Volume: 55 Issue: 54 Pages: 7792-7795
- DOI
  10.1039/c9cc02203a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K14880, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502
[Journal Article] Molecular mechanisms of cereblon-based drugs2019
- Author(s)
  Asatsuma-Okumura Tomoko、Ito Takumi、Handa Hiroshi
- Journal Title
  
  Pharmacology & Therapeutics
  
  Volume: 202 Pages: 132-139
- DOI
  10.1016/j.pharmthera.2019.06.004
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-17H04213
[Journal Article] Development of small molecule chimeric degraders that bring target proteins and the aryl hydrocarbon receptor (AhR) E3 ligase into close proximity2019
- Author(s)
  N. Ohoka, G. Tsuji, T. Shoda, T. Fujisato, M. Kurihara, Y. Demizu, M. Naito*
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 14 Issue: 12 Pages: 2822-2832
- DOI
  10.1021/acschembio.9b00704
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07009, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16K08340
[Journal Article] Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein2019
- Author(s)
  Shibata Norihito、Ohoka Nobumichi、Hattori Takayuki、Naito Mikihiko
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 67 Issue: 3 Pages: 165-172
- DOI
  10.1248/cpb.c18-00703
- NAID
  130007606378
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2019-03-01
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-18K07311, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation2018
- Author(s)
  Ohoka Nobumichi、Morita Yoko、Nagai Katsunori、Shimokawa Kenichiro、Ujikawa Osamu、Fujimori Ikuo、Ito Masahiro、Hayase Youji、Okuhira Keiichiro、Shibata Norihito、Hattori Takayuki、Sameshima Tomoya、Sano Osamu、Koyama Ryokichi、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 18 Pages: 6776-6790
- DOI
  10.1074/jbc.ra117.001091
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase2018
- Author(s)
  Shibata Norihito、Shimokawa Kenichiro、Nagai Katsunori、Ohoka Nobumichi、Hattori Takayuki、Miyamoto Naoki、Ujikawa Osamu、Sameshima Tomoya、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 13549-13549
- DOI
  10.1038/s41598-018-31913-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Structural basis of thalidomide enantiomer binding to cereblon.2018
- Author(s)
  Mori, T., Itoh, T., Liu, S., Ando, H., Sakamoto, S., Yamaguchi, Y., Tokunaga, E., Shibata, N., Handa, H. and Hakoshima, T.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 1294-1294
- DOI
  10.1038/s41598-018-19202-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26251006, KAKENHI-PROJECT-15H04288, KAKENHI-PROJECT-17H04213, KAKENHI-PROJECT-17H06112
[Journal Article] NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation.2018
- Author(s)
  1. Kimura, A., Kitajima, M., Nishida, K., Serada, S., Fujimoto, M., Naka, T., Fuji-Kuriyama, Y., Ito, T., Handa, H., Tanaka, T, Yoshimura, A., Suzuki, H.
- Journal Title
  
  Journal of experimental medicine
  
  Volume: 215 Issue: 8 Pages: 2197-2200
- DOI
  10.1084/jem.20172024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08803, KAKENHI-PROJECT-17H06112, KAKENHI-PROJECT-17H04213, KAKENHI-PROJECT-17K08896
[Journal Article] Discovery of the target for immunomodulatory drugs (IMiDs)2016
- Author(s)
  伊藤拓水、安藤秀樹、半田宏
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 57 Issue: 5 Pages: 556-562
- DOI
  10.11406/rinketsu.57.556
- NAID
  130005155372
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-26750374
[Journal Article] Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs.2016
- Author(s)
  Ito T and Handa H.
- Journal Title
  
  Int J Hematol
  
  Volume: 104 Issue: 3 Pages: 293-299
- DOI
  10.1007/s12185-016-2073-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26750374
[Journal Article] サリドマイドの標的ユビキチンリガーゼ“セレブロン”とその機能2016
- Author(s)
  伊藤拓水、半田宏
- Journal Title
  
  医学のあゆみ
  
  Volume: 256 Pages: 891-895
- Data Source
  KAKENHI-PROJECT-26750374
[Journal Article] A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.2016
- Author(s)
  Matyskiela ME, Lu G, Ito T, Pagarigan B, Lu CC, Miller K, Fang W, Wang NY, Nguyen D, Houston J, Carmel G, Tran T, Riley M, Nosaka L, Lander GC, Gaidarova S, Xu S, Ruchelman AL, Handa H, Carmichael J, Daniel TO, Cathers BE, Lopez-Girona A, Chamberlain PP.
- Journal Title
  
  Nature
  
  Volume: 535 Issue: 7611 Pages: 252-257
- DOI
  10.1038/nature18611
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26750374
[Journal Article] 半田ビーズを用いたサリドマイド標的同定2015
- Author(s)
  坂本聡、伊藤拓水、半田宏
- Journal Title
  
  CSJカレントレビュー
  
  Volume: 19 Pages: 86-93
- Data Source
  KAKENHI-PROJECT-26750374
[Journal Article] Myeloid disease: Another action of a thalidomide derivative2015
- Author(s)
  Takumi Ito, Hiroshi Handa
- Journal Title
  
  Nature
  
  Volume: 523 Issue: 7559 Pages: 167-168
- DOI
  10.1038/nature14628
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26750374, KAKENHI-PLANNED-23102002
[Journal Article] Structure of the human cereblon-DDB1- lenalidomide complex reveals basis for responsiveness to thalidomide analogs2014
- Author(s)
  P. Chamberlain, A. Lopez-Girona, K. Miller, G. Carmel, B. Pagarigan, B. Chie-Leon, E. Rychak, L. Corral, Y. Ren, M. Wang, M. Riley, S. Delker, T. Ito, H. Ando, T. Mori, Y. Hirano, H. Handa, T. Hakoshima, T. Daniel, B. Cathers
- Journal Title
  
  Nat. Struct. Mol. Biol.
  
  Volume: 21 Issue: 9 Pages: 803-809
- DOI
  10.1038/nsmb.2874
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102002, KAKENHI-PROJECT-24241043, KAKENHI-PROJECT-25440025, KAKENHI-PROJECT-26750374
[Journal Article] Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN)2014
- Author(s)
  A. K. Gandhi, J. Kang, C. G. Havens, T. Conklin, Y. Ning, L. Wu, T. Ito, H. Ando, M. F. Waldman, A. Thakurta, A. Klippel, H. Handa, T.O. Daniel, P. H. Schafer, R. Chopra
- Journal Title
  
  Br. J. Haematol.
  
  Volume: 164 Issue: 6 Pages: 811-821
- DOI
  10.1111/bjh.12708
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102002, KAKENHI-PROJECT-23710267, KAKENHI-PROJECT-24241043
[Journal Article] セレブロン～IMiDsの標的因子～2013
- Author(s)
  安藤秀樹、伊藤拓水、半田宏
- Journal Title
  
  血液フロンティア
  
  Volume: 23 Pages: 1288-1292
- Data Source
  KAKENHI-PROJECT-23710267
[Journal Article] Vesnarinone Suppresses TNF α mRNA Expression by Inhibiting Valosin-containing Protein2013
- Author(s)
  Hotta K, Nashimoto A, Yasumura E, Suzuki M, Azuma M, Iizumi Y, Shima D, Nabeshima R, Hiramoto M, Okada A, Sakata-Sogawa K, Tokunaga M, Ito T, Ando H, Sakamoto S, Kabe Y, Aizawa S, Imai T, Yamaguchi Y, Watanabe H, Handa H
- Journal Title
  
  Mol Pharmacol
  
  Volume: Vol.83 Issue: 5 Pages: 930-938
- DOI
  10.1124/mol.112.081935
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20114004, KAKENHI-PLANNED-23102004, KAKENHI-PROJECT-23570172, KAKENHI-PROJECT-23689036, KAKENHI-PROJECT-23710267, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118002, KAKENHI-PROJECT-24650231, KAKENHI-PLANNED-23102002, KAKENHI-PLANNED-24118006
[Journal Article] セレブロン～IMiDsの標的因子～2013
- Author(s)
  安藤秀樹、伊藤拓水、半田宏
- Journal Title
  
  血液フロンティア, 医薬ジャーナル社
  
  Volume: Vol.23 No.9 Pages: 1288-1292
- Data Source
  KAKENHI-PROJECT-23710267
[Journal Article] サリドマイドの悲劇：その後の研究2013
- Author(s)
  伊藤拓水、安藤秀樹、半田　宏
- Journal Title
  
  キラル化学 -その起源から最新のキラル材料研究まで- CSJカレントレビュー
  
  Volume: 13 Pages: 180-182
- Data Source
  KAKENHI-PROJECT-23710267
[Journal Article] トピックス : サリドマイドの悲劇-その後の研究2013
- Author(s)
  伊藤拓水、安藤秀樹、半田宏
- Journal Title
  
  キラル化学 -その起源から最新のキラル材料研究まで-CSJカレントレビュー
  
  Volume: 第13号 Pages: 180-182
- Data Source
  KAKENHI-PROJECT-23710267
[Journal Article] Tools and methodologies capable of isolating and identifying a target molecule for a bioactive compound2012
- Author(s)
  Sakamoto, S., Hatakeyama, M., Ito, T. and Handa, H.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 20 Issue: 6 Pages: 1990-2001
- DOI
  10.1016/j.bmc.2011.12.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710267, KAKENHI-PLANNED-23102002
[Journal Article] サリドマイド・IMiDsの作用とユビキチンリガーゼ2012
- Author(s)
  伊藤拓水、半田宏
- Journal Title
  
  医学のあゆみ, 医歯薬出版株式会社
  
  Volume: Vol.243 No.6 Pages: 503-507
- Data Source
  KAKENHI-PROJECT-23710267
[Journal Article] Deciphering the mystery of thalidomide teratogenicity2012
- Author(s)
  Ito, T. and Handa, H.
- Journal Title
  
  Congenital Anomalies
  
  Volume: 52 Issue: 1 Pages: 1-7
- DOI
  10.1111/j.1741-4520.2011.00351.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710267, KAKENHI-PLANNED-23102002
[Journal Article] Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of Bisphenol A.2012
- Author(s)
  Ito, Y., Ito, T., Karasawa, S., Enomoto, T., Nashimoto, A., Hase, Y., Sakamoto, S., Ito, T., Mimori, T., Matsumoto, Y., Yamaguchi, Y., Handa, H.
- Journal Title
  
  PLos ONE
  
  Volume: 7(12) Issue: 12 Pages: e50481-e50481
- DOI
  10.1371/journal.pone.0050481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689033, KAKENHI-PROJECT-23710267, KAKENHI-PLANNED-23102002, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118002
[Journal Article] IMiDsの標的分子探索研究の進歩2012
- Author(s)
  伊藤拓水、安藤秀樹、半田宏
- Journal Title
  
  血液内科, 科学評論社
  
  Volume: Vol.64 No.4 Pages: 440-445
- Data Source
  KAKENHI-PROJECT-23710267
[Journal Article] Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide.2012
- Author(s)
  Lopez-Girona A, Mendy D, Ito T et al.
- Journal Title
  
  Leukemia.
  
  Volume: 26 Issue: 11 Pages: 2326-2335
- DOI
  10.1038/leu.2012.119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710267, KAKENHI-PLANNED-23102002
[Journal Article] サリドマイドの催奇性メカニズム2011
- Author(s)
  伊藤拓水、安藤秀樹、半田宏
- Journal Title
  
  化学と生物
  
  Volume: Vol.49, No.12 Pages: 819-824
- NAID
  10030400532
- Data Source
  KAKENHI-PROJECT-23710267
[Patent] METHODS OF USING AN ACTIVATOR OF CEREBLON FOR NEURAL CELL EXPANSION AND THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS2015
- Inventor(s)
  Handa H, Ando H, Ito H
- Industrial Property Rights Holder
  Handa H, Ando H, Ito H
- Industrial Property Rights Type
  特許
- Filing Date
  2015-02-23
- Acquisition Date
  2015-08-27
- Overseas
- Data Source
  KAKENHI-PROJECT-26750374
[Presentation] 高い抗菌活性を有するステープルペプチドの創製2022
- Author(s)
  伊藤貴仁，三澤隆史，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] リンカー構造に着目したH-PGDS分解誘導剤の構造活性相関研究2022
- Author(s)
  大澤陽，黒原崇，横尾英知，伊藤貴仁，栁瀨雄太，柴田識人，大槻崇，松藤寛，有竹浩介，内藤幹彦，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 造血器型プロスタグランジンD合成酵素選択的タンパク質分解誘導剤の開発2022
- Author(s)
  柴田識人，横尾英知，遠藤彬則，伊藤貴仁，栁瀨雄太，村上優貴，藤井清永，佐伯泰，内藤幹彦，有竹浩介，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Technologies to induce targeted protein degradation and their application for drug development2022
- Author(s)
  Mikihiko Naito
- Organizer
  The 95th Annual Meeting of the Japanese Pharmaceutical Society
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 多様なカチオン性アミノ酸を導入した抗菌ペプチドフォルダマーの開発2022
- Author(s)
  髙田真有，伊藤貴仁，平野元春，土屋圭輔，三澤隆史，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Specific degrader of hematopoietic prostaglandin D synthase prevented the progression of dilated cardiomyopathy in Duchenne muscular dystrophy2022
- Author(s)
  Maeyama, Y., Hosokawa, Y., Hamamura, K., Yokoo, H., Shibata, N., Naito, M., Demizu, Y., Aritake, K.
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] H-PGDS分解誘導剤の構造活性相関研究2022
- Author(s)
  村上優貴，黒原崇，横尾英知，伊藤貴仁，柳瀬雄太，柴田識人，有竹浩介，内藤幹彦，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 造血器型プロスタグランジンD合成酵素を標的とした選択的タンパク質分解誘導剤の開発2021
- Author(s)
  柴田識人，横尾英知，遠藤彬則，伊藤貴仁，栁瀨雄太，村上優貴，藤井清永，佐伯泰，内藤幹彦，有竹浩介，出水庸介
- Organizer
  第94回日本生化学大会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Peptide stapling improves the sustainability of peptide-based degraders against estrogen receptors2021
- Author(s)
  横尾英知，大岡伸通，大庭誠，伊藤貴仁，井上貴雄，内藤幹彦，出水庸介
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 高活性・高選択的な造血器型プロスタグランジンD合成酵素分解誘導剤の開発2021
- Author(s)
  横尾英知，柴田識人，遠藤彬則，伊藤貴仁，柳瀬雄太，村上優貴，藤井清永，大庭誠，佐伯泰，内藤幹彦，有竹浩介，出水庸介
- Organizer
  ケミカルバイオロジー第15回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] セレブロンを標的とする薬剤の分子機構2021
- Author(s)
  伊藤　拓水
- Organizer
  第424回CBI学会研究講演会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Development of Highly Selective Anti-Cancer Drugs by Targeted Protein Degradation.2021
- Author(s)
  Mikihiko Naito
- Organizer
  The 44th Annual Meeting of the Molecular Biology Society of Japan
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Molecular mechanisms of cereblon-based drugs2021
- Author(s)
  伊藤拓水
- Organizer
  第44回日本分子生物学会年会　新学術領域研究ケモユビキチン共催シンポジウム「躍進するユビキチンケモテクノロジー研究」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Discovery of a highly potent and selective PROTAC targeting hematopoietic prostaglandin D synthase via in silico design2021
- Author(s)
  Yokoo, H., Shibata, N., Endo, A., Ito, T., Yanase, Y., Murakami, Y., Fujii, K., Saeki, Y., Naito, M., Aritake, K., Demizu, Y.
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 造血器型プロスタグランジンD合成酵素分解誘導剤の創製2021
- Author(s)
  村上優貴，大澤陽，柴田識人，横尾英知，伊藤貴仁，柳瀬雄太，黒原崇，出水庸介
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Thalidomide存在下におけるCRBNネオ基質2021
- Author(s)
  伊藤拓水、朝妻知子、半田宏
- Organizer
  第25回がん分子標的標的治療学会学術集会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Recent Advance in the Immunotherapy for Multiple Myeloma2021
- Author(s)
  Takumi Ito
- Organizer
  第83回日本血液学会学術集会 JSH-ASH Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Targeted Protein Degradation by Small Molecules2020
- Author(s)
  Mikihiko Naito
- Organizer
  第79回日本癌学会総会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] サリドマイドおよび誘導体の分子機構2020
- Author(s)
  伊藤拓水、半田宏
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Hijacking IAP ubiquitin ligases by SNIPERs to induce protein degradation.2019
- Author(s)
  Mikihiko Naito
- Organizer
  第78回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] A novel strategy for destabilizion of oncogenic fusion protein BCR-ABL to inhibit the growth of chronic myelogenous leukemea2019
- Author(s)
  Norihito Shibata, Nobumichi Ohoka, Mikihiko Naito
- Organizer
  日本薬学会第139年会　国際創薬シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Induced Protein Degradation by Chimeric Small Molecules; Recent Progress and Outlook.2019
- Author(s)
  Mikihiko Naito
- Organizer
  Targeted Protein Degradation forum in Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Development of amphipathic cell-penetrating foldamers for delivery of biomacromolecules2019
- Author(s)
  Misawa T, Ohoka N, Goto C, Oba M, Tanaka M, Naito M, Demizu Y.
- Organizer
  European Symposium on Organic Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] CRBNを標的とする薬剤の分子機構2019
- Author(s)
  伊藤拓水、半田宏
- Organizer
  第19回日本蛋白質科学会年会・第71回日本細胞生物学会大会合同年次大会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] セレブロンを標的とする薬剤の分子機構2019
- Author(s)
  伊藤拓水
- Organizer
  バイオインタラクション研究会第６回ワークショップ
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] セレブロンを標的とする薬剤の分子機構2019
- Author(s)
  伊藤拓水
- Organizer
  バイオインタラクション研究会第６回ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-17H04213
[Presentation] Hijacking IAP ubiquitin ligases by SNIPERs to induce protein degradation.2019
- Author(s)
  Mikihiko Naito
- Organizer
  Symposium on Frontier in PROTAC Drug Discovery and Development
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Cereblon modulators2019
- Author(s)
  Takumi Ito
- Organizer
  RIKEN Epigenetics in Wako 2019
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] セレブロンモジュレーターの分子機構2019
- Author(s)
  伊藤拓水、半田宏
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] SNIPERs: Hijacking IAP Ubiquitin Ligases for Targeted Protein Degradation2019
- Author(s)
  Mikihiko Naito
- Organizer
  2nd Annual Targeted Protein Degradation Summit
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 新規セレブロンモジュレーターの分子機構の解析2018
- Author(s)
  伊藤拓水、半田宏
- Organizer
  第41回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H04213
[Presentation] Derivatization of IAP ligand to develop SNIPERs with improved protein knockdown and antitumor activity2018
- Author(s)
  Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori, Mikihiko Naito
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Inducing target-specific protein degradation by SNIPER compounds recruiting IAP ubiquitin ligases2018
- Author(s)
  Mikihiko Naito
- Organizer
  第41回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] セレブロンモジュレーターによるユビキチンリガーゼ制御工学2018
- Author(s)
  伊藤拓水、　半田宏
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04213
[Presentation] 新規セレブロンモジュレーターの分子機構の解析2018
- Author(s)
  伊藤拓水、半田宏
- Organizer
  第41回分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Development of Protein Knockdown Technology to Induce Selective Degradation of Target Proteins2018
- Author(s)
  Mikihiko Naito
- Organizer
  薬物動態懇話会第41回年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinases2018
- Author(s)
  Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Recent Advances in Bifunctional Degrader Molecules (e.g. SNIPER) for Targeted Protein Degradation via the Ubiquitin Proteasome System; Status and Outlook2018
- Author(s)
  Mikihiko Naito
- Organizer
  EFMC-ISMC 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Ligand-directed degradation of GSPT1 by a novel cereblon modulator drives potent antitumor effects2017
- Author(s)
  Matyskiela M, Lu G, Ito T, Pagarigan B, Lu CC, Miller K, Fang W, Wang NY, Nguyen D, Houston J, Carmel G, Tran T, Riley M, Nosaka L, Lander G, Gaidarova S, Xu S, Ruchelman A, Handa H, Carmichale J, Daniel TO, Cathers BE, Lopez-Girona A and Chamberlain P
- Organizer
  AACR Annual Meeting 2017
- Data Source
  KAKENHI-PROJECT-17H04213
[Presentation] リガンド依存的ユビキチンリガーゼCRBNの制御機構2016
- Author(s)
  伊藤拓水、朝妻知子、山本淳一、安藤秀樹、佐藤智美、山口雄輝、半田宏
- Organizer
  日本ケミカルバイオロジー学会第11回年会
- Place of Presentation
  京都テルサ, 京都
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-26750374
[Presentation] 急性骨髄性白血病に有効な新規セレブロンモジュレーターの開発2016
- Author(s)
  伊藤拓水、半田宏
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター、仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26750374
[Presentation] 急性骨髄性白血病に効果を示す新規のセレブロンモジュレーター2016
- Author(s)
  伊藤拓水、半田宏
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26750374
[Presentation] Cereblon is a substrate receptor of the Cul4 ubiquitin ligase whose substrate recognition is modulated by IMiDs.2014
- Author(s)
  伊藤拓水、安藤秀樹、山口雄輝、半田宏
- Organizer
  Cold Spring Harbor Asia - Protein Modification & Homeostasis conference
- Place of Presentation
  蘇州、中国
- Year and Date
  2014-06-18
- Invited
- Data Source
  KAKENHI-PROJECT-26750374
[Presentation] Cereblon is a substrate receptor of the Cul4 ubiquitin ligase whose substrate recognition is modulated by IMiDs.2014
- Author(s)
  伊藤拓水、安藤秀樹、山口雄輝、半田宏
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜、神奈川
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-26750374
[Presentation] サリドマイド類似薬の分子機構ー最新の知見2014
- Author(s)
  伊藤　拓水
- Organizer
  次世代型がん研究戦略セミナー
- Place of Presentation
  東京医科大学教育研究棟、東京
- Invited
- Data Source
  KAKENHI-PROJECT-23710267
[Presentation] サリドマイド標的因子セレブロン : その発見から最新の知見まで2012
- Author(s)
  伊藤拓水、半田宏
- Organizer
  第23回生殖・発生毒性学東京セミナー
- Place of Presentation
  独立行政法人国立オリンピック記念青少年総合センター
- Year and Date
  2012-10-05
- Invited
- Data Source
  KAKENHI-PROJECT-23710267
[Presentation] サリドマイドによる催奇形性の分子機構2011
- Author(s)
  伊藤拓水、安藤秀樹、山口雄輝、半田宏
- Organizer
  第29回日本骨代謝学会学術集会(招待講演)
- Place of Presentation
  大阪国際会議場（グランキューブ大阪）
- Data Source
  KAKENHI-PROJECT-23710267
[Presentation] サリドマイドによる催奇形性の分子機構2011
- Author(s)
  伊藤拓水、安藤秀樹、山口雄輝、半田宏
- Organizer
  第29回日本骨代謝学会学術集会
- Place of Presentation
  大阪国際会議場(グランキューブ大阪)
- Year and Date
  2011-07-30
- Invited
- Data Source
  KAKENHI-PROJECT-23710267
[Presentation] サリドマイド抗がん作用におけるターゲット分子Cereblon
- Author(s)
  伊藤拓水, ティプランパイタンマモングッド, 唐澤慧記, 坂田未希, 舩造正英, 若林知伸, 飯田結, 山口雄輝, 半田宏
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-23710267
[Presentation] サリドマイド標的因子セレブロン：その発見から最新の知見まで
- Author(s)
  伊藤拓水、半田宏
- Organizer
  第23 回生殖・発生毒性学東京セミナー
- Place of Presentation
  独立行政法人国立オリンピック記念青少年総合センター
- Invited
- Data Source
  KAKENHI-PROJECT-23710267

1. 出水庸介 (90389180)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
2. 内藤幹彦 (00198011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 28 results
3. 石川稔 (70526839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. SYODA Takuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 朝妻知子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 大岡伸通

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
7. 半田宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 奥平桂一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 十川久美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 徳永万喜洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 佐藤智美

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 柴田識人

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
13. 箱嶋敏雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 松本義久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 百瀬修二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 北島雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 横尾英知

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ito Takumi 伊藤 拓水

ITO Takumi 伊藤 拓水

Research Projects

Research Products

Co-Researchers

Controlling the lifetime of proteins using chemical degraders

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Elucidation of the therapeutic mechanisms of IMiDsPrincipal Investigator

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Chemical protein knockdown technology and cell regulation

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Elucidation of the molecular basis of IMiDs' actionPrincipal Investigator

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Elucidation of the molecular mechanism of the anti-cancer activity of IMiDsPrincipal Investigator

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Analysis of thalidomide induced CRBN-E3-ubiquitin-ligase inhibition mechanismPrincipal Investigator

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[Book] "Chapter 16， Protein degradation inducers SNIPERs and PROTACs against oncogenic proteins, In Pharmaceutical Biocatalysis Fundamentals, Enzyme Inhibitors, and Enzymes in Health and Diseases"2019

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[Book] Development of a new affinity nanobead technology and target isolatioin of bioactive compounds2018

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[Book] IMiDs（免疫調整薬）の現状と展望2015

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[Book] 日本臨牀（特集：多発性骨髄腫の病態と最新治療―基礎と臨床の最新情報ー2015

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[Book] 生物活性分子の標的同定と機能解明（CSJカレントビュー第19号）2015

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[Book] Organ Biology 21巻２号2014

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[Journal Article] Molecular Design, Synthesis, and Evaluation of SNIPER (ER) that Induces Targeted Protein Degradation of ERα2022

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[Journal Article] Development of a degrader against oncogenic fusion protein FGFR3-TACC32022

Ito Takumi 伊藤拓水

ITO Takumi 伊藤拓水