Ito Takumi 伊藤拓水

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ITO Takumi 伊藤拓水

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Researcher Number	30533179
Other IDs	https://orcid.org/0000-0002-9997-2664
Affiliation (Current)	2022: 東京医科大学, 医学部, 客員准教授
Affiliation (based on the past Project Information) *help	2022: 東京医科大学, 医学部, 客員准教授 2016 – 2022: 東京医科大学, 医学部, 准教授 2013 – 2015: 東京医科大学, 医学部, 講師 2012: 東京工業大学, 生命理工学研究科, 特任助教 2011: 東京工業大学, ソリューション研究機構, ソリューション研究員
Review Section/Research Field	Principal Investigator Chemical biology / Chemical biology / Hematology / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Complex systems
Keywords	Principal Investigator サリドマイド / セレブロン / ユビキチン / IMiDs / 多発性骨髄腫 / ケミカルバイオロジー / ユビキチンリガーゼ / 催奇性 / E3 / ポマリドマイド … More / レナリドマイド / GSPT1 / CC-885 / レナリドミド / ポマリドミド / 急性骨髄性白血病 / PROTACs / CRBN / ネオ基質 / タンパク質分解 / 骨髄腫 / ケミカルジェネティクス … More Except Principal Investigator ケミカルプロテインノックダウン / SNIPER / PROTAC / セレブロンモジュレーター / ユビキチン / タンパク質分解 / ステープルペプチド / サリドマイド / 血管新生 / 脱ユビキチン化酵素 / セレブロン / プロテアソーム / IAP / ペプチド Less

Elucidation of the therapeutic mechanisms of IMiDsPrincipal Investigator
- Principal Investigator
  
  伊藤拓水
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokyo Medical University
Chemical protein knockdown technology and cell regulation
- Principal Investigator
  
  内藤幹彦
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
  National Institute of Health Sciences
Elucidation of the molecular basis of IMiDs' actionPrincipal Investigator
- Principal Investigator
  
  Ito Takumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical University
Elucidation of the molecular mechanism of the anti-cancer activity of IMiDsPrincipal Investigator
- Principal Investigator
  
  Ito Takumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  Tokyo Medical University
Analysis of thalidomide induced CRBN-E3-ubiquitin-ligase inhibition mechanismPrincipal Investigator
- Principal Investigator
  
  ITO Takumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  Tokyo Medical University
  Tokyo Institute of Technology

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book Patent

[Book] "Chapter 16， Protein degradation inducers SNIPERs and PROTACs against oncogenic proteins, In Pharmaceutical Biocatalysis Fundamentals, Enzyme Inhibitors, and Enzymes in Health and Diseases"2019
- Author(s)
  Shibata N, Ohoka N, Hattori T, Naito M.
- Total Pages
  20
- Publisher
  Jenny Stanford Publishing
- ISBN
  9789814800617
- Data Source
  KAKENHI-PLANNED-18H05502
[Book] Development of a new affinity nanobead technology and target isolatioin of bioactive compounds2018
- Author(s)
  Takumi Ito, Mamoru Hatakeyama, Hiroshi Handa
- Total Pages
  27
- Publisher
  IOP Publishing Ltd
- ISBN
- Data Source
  KAKENHI-PLANNED-18H05502
[Book] IMiDs（免疫調整薬）の現状と展望2015
- Author(s)
  伊藤拓水、安藤秀樹、半田宏
- Total Pages
  233
- Publisher
  （株）メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-26750374
[Book] 日本臨牀（特集：多発性骨髄腫の病態と最新治療―基礎と臨床の最新情報ー2015
- Author(s)
  伊藤拓水、安藤秀樹、半田宏
- Total Pages
  182
- Publisher
  （株）日本臨牀社
- Data Source
  KAKENHI-PROJECT-26750374
[Book] 生物活性分子の標的同定と機能解明（CSJカレントビュー第19号）2015
- Author(s)
  坂本聡、伊藤拓水、半田宏
- Total Pages
  189
- Publisher
  （株）化学同人
- Data Source
  KAKENHI-PROJECT-26750374
[Book] Organ Biology 21巻２号2014
- Author(s)
  伊藤拓水、安藤秀樹、半田宏
- Total Pages
  273
- Publisher
  （株）日本医学館
- Data Source
  KAKENHI-PROJECT-26750374
[Journal Article] TRIP12 promotes small molecule-induced degradation of BRD4 through K29/K48 branched ubiquitin chains.2021
- Author(s)
  Kaiho-Soma Ai、Akizuki Yoshino、Igarashi Katsuhide、Endo Akinori、Shoda Takuji、Kawase Yasuko、Demizu Yosuke、Naito Mikihiko、Saeki Yasushi、Tanaka Keiji、Ohtake Fumiaki
- Journal Title
  
  Mol Cell
  
  Volume: 81
- DOI
  10.1016/j.molcel.2021.01.023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07009, KAKENHI-PROJECT-20K22726, KAKENHI-PROJECT-17H01882, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-19H00997, KAKENHI-PLANNED-18H05498
[Journal Article] Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer2021
- Author(s)
  Yokoo Hidetomo、Shibata Norihito、Naganuma Miyako、Murakami Yuki、Fujii Kiyonaga、Ito Takahito、Aritake Kosuke、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 12 Pages: 236-241
- DOI
  10.1021/acsmedchemlett.0c00605
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07311, KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502
[Journal Article] Gluing Proteins for Targeted Degradation2021
- Author(s)
  Naito Mikihiko、Murata Shigeo
- Journal Title
  
  Cancer Cell
  
  Volume: 39 Pages: 19-21
- DOI
  10.1016/j.ccell.2020.12.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine2021
- Author(s)
  Tomomi Sato, Takumi Ito and Hiroshi Handa
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 9 Pages: 629326-629326
- DOI
  10.3389/fcell.2021.629326
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09271, KAKENHI-PLANNED-18H05502
[Journal Article] Molecular Glue Degrader2021
- Author(s)
  伊藤拓水、朝妻知子、半田宏
- Journal Title
  
  細胞
  
  Volume: 53 Pages: 140-143
- NAID
  40022519984
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence2021
- Author(s)
  Hirano Motoharu、Saito Chihiro、Yokoo Hidetomo、Goto Chihiro、Kawano Ryuji、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  Molecules
  
  Volume: 26 Pages: 444-444
- DOI
  10.3390/molecules26020444
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18K14880
[Journal Article] Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy.2020
- Author(s)
  Yamano Koji、Kikuchi Reika、Kojima Waka、Hayashida Ryota、Koyano Fumika、Kawawaki Junko、Shoda Takuji、Demizu Yosuke、Naito Mikihiko、Tanaka Keiji、Matsuda Noriyuki
- Journal Title
  
  J. Cell Biol.
  
  Volume: 219 Pages: 1-1
- DOI
  10.1083/jcb.201912144
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K07009, KAKENHI-PLANNED-18H05500, KAKENHI-PLANNED-18H05502, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K06237
[Journal Article] Molecular mechanisms of thalidomide and its derivatives2020
- Author(s)
  ITO Takumi、HANDA Hiroshi
- Journal Title
  
  Proc. Jpn. Acad., Ser. B
  
  Volume: 96 Issue: 6 Pages: 189-203
- DOI
  10.2183/pjab.96.016
- NAID
  130007853739
- ISSN
  0386-2208, 1349-2896
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] Molecular Mechanisms of the Teratogenic Effects of Thalidomide2020
- Author(s)
  Asatsuma-Okumura Tomoko、Ito Takumi、Handa Hiroshi
- Journal Title
  
  Pharmaceuticals
  
  Volume: 13 Pages: 95-95
- DOI
  10.3390/ph13050095
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] Design and synthesis of peptide-based chimeric molecules to induce degradation of the estrogen and androgen receptors.2020
- Author(s)
  Yokoo Hidetomo、Ohoka Nobumichi、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  Bioorg Med Chem.
  
  Volume: 28 Pages: 115595-115595
- DOI
  10.1016/j.bmc.2020.115595
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-PLANNED-18H05502
[Journal Article] サリドマイドの作用機序とセレブロンモジュレーター2020
- Author(s)
  伊藤拓水、半田宏
- Journal Title
  
  実験医学
  
  Volume: 38 Pages: 2310-2314
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells.2020
- Author(s)
  Shibata Norihito、Ohoka Nobumichi、Tsuji Genichiro、Demizu Yosuke、Miyawaza Keiji、Ui-Tei Kumiko、Akiyama Tetsu、Naito Mikihiko
- Journal Title
  
  Oncogene
  
  Volume: - Pages: 3867-3878
- DOI
  10.1038/s41388-020-1253-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07311, KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-17H01537, KAKENHI-PROJECT-17K08385, KAKENHI-PLANNED-18H05502
[Journal Article] Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs2020
- Author(s)
  Ishikawa Minoru、Tomoshige Shusuke、Demizu Yosuke、Naito Mikihiko
- Journal Title
  
  Pharmaceuticals
  
  Volume: 13 Pages: 74-74
- DOI
  10.3390/ph13040074
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K16326, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18H02551
[Journal Article] ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells2020
- Author(s)
  Yamamoto J, Suwa T, Murase Y, Tateno S, Mizutome H, Asatsuma-Okumura T, Shimizu N, Kishi T, Momose S, Kizaki M, Ito T, Yamaguchi Y, Handa H.
- Journal Title
  
  Nat. Chem. Biol.
  
  Volume: 16 Pages: 1208-1217
- DOI
  10.1038/s41589-020-0645-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07396, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-20H03182, KAKENHI-PROJECT-19K16378
[Journal Article] Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide2020
- Author(s)
  Tateno Shumpei、Iida Midori、Fujii Satoshi、Suwa Tetsufumi、Katayama Miki、Tokuyama Haruka、Yamamoto Junichi、Ito Takumi、Sakamoto Satoshi、Handa Hiroshi、Yamaguchi Yuki
- Journal Title
  
  Sci. Rep.
  
  Volume: 10 Pages: 4012-4012
- DOI
  10.1038/s41598-020-61027-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-17H06112, KAKENHI-PROJECT-17H04213, KAKENHI-PROJECT-20H03182
[Journal Article] Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety2020
- Author(s)
  Shoda T, Ohoka N, Tsuji G, Fujisato T, Inoue H, Demizu Y, Naito M, Kurihara M.
- Journal Title
  
  Pharmaceuticals
  
  Volume: 13 Pages: 34-34
- DOI
  10.3390/ph13030034
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07009, KAKENHI-PLANNED-18H05502
[Journal Article] SNIPERs?Hijacking IAP activity to induce protein degradation2019
- Author(s)
  Naito M, Ohoka N, Shibata N.
- Journal Title
  
  Drug Discov Today Technol.
  
  Volume: 印刷中 Pages: 35-42
- DOI
  10.1016/j.ddtec.2018.12.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-18K06567, KAKENHI-PLANNED-18H05502
[Journal Article] p63 is a cereblon substrate involved in the thalidomide teratogenicity2019
- Author(s)
  Asatsuma-Okumura Tomoko、Ando Hideki、De Simone Marco、Yamamoto Junichi、Sato Tomomi、Shimizu Nobuyuki、Asakawa Kazuhide、Yamaguchi Yuki、Ito Takumi、Guerrini Luisa、Handa Hiroshi
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 15 Pages: 1077-1084
- DOI
  10.1038/s41589-019-0366-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-17H06112, KAKENHI-PROJECT-15H04288, KAKENHI-PROJECT-17H04213
[Journal Article] Rational design of novel amphipathic antimicrobial peptides focused on distribution of cationic amino acid residues2019
- Author(s)
  Misawa T, Goto C, Shibata N, Hirano M, Kikuchi Y, Naito M, Demizu Y
- Journal Title
  
  MedChemComm
  
  Volume: 印刷中 Pages: 896-900
- DOI
  10.1039/c9md00166b
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-17K08385
[Journal Article] Cereblon control of zebrafish brain size by regulation of neural stem cell proliferation.2019
- Author(s)
  Hideki Ando, Tomomi Sato, Takumi Ito, Junichi Yamamoto, Satoshi Sakamoto, Nobuhiro Nitta, Tomoko Asatsuma-Okumura, Nobuyuki Shimizu, Ryota Mizushima, Ichio Aoki, Takeshi Imai, Yuki Yamaguchi, Arnold J Berk, and Hiroshi Handa
- Journal Title
  
  iScience
  
  Volume: 15 Pages: 95-108
- DOI
  10.1016/j.isci.2019.04.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09271, KAKENHI-PROJECT-17H06112, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-17H04213
[Journal Article] Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs2019
- Author(s)
  Naito M, Ohoka N, Shibata N, Tsukumo Y.
- Journal Title
  
  Frontiers in Chemistry
  
  Volume: 7 Pages: 1-5
- DOI
  10.3389/fchem.2019.00849
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07724, KAKENHI-PLANNED-18H05502
[Journal Article] Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER)2019
- Author(s)
  Ohoka Nobumichi、Ujikawa Osamu、Shimokawa Kenichiro、Sameshima Tomoya、Shibata Norihito、Hattori Takayuki、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  CHEMICAL & PHARMACEUTICAL BULLETIN
  
  Volume: 67 Issue: 3 Pages: 203-209
- DOI
  10.1248/cpb.c18-00567
- NAID
  130007607114
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery2019
- Author(s)
  T. Misawa,* N. Ohoka,* M. Oba, H. Yamashita, M. Tanaka, M. Naito, Y. Demizu*
- Journal Title
  
  Chemical Communications
  
  Volume: 55 Pages: 7792-7795
- DOI
  10.1039/c9cc02203a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K14880, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502
[Journal Article] Molecular Mechanisms of Cereblon-Based Drugs2019
- Author(s)
  Asatsuma-Okumura Tomoko、Ito Takumi、Handa Hiroshi
- Journal Title
  
  Pharmacology & Therapeutics
  
  Volume: 202 Pages: 132-139
- DOI
  10.1016/j.pharmthera.2019.06.004
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-17H04213
[Journal Article] Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein2019
- Author(s)
  Shibata Norihito、Ohoka Nobumichi、Hattori Takayuki、Naito Mikihiko
- Journal Title
  
  CHEMICAL & PHARMACEUTICAL BULLETIN
  
  Volume: 67 Issue: 3 Pages: 165-172
- DOI
  10.1248/cpb.c18-00703
- NAID
  130007606378
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-18K07311, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins.2019
- Author(s)
  N. Ohoka, G. Tsuji, T. Shoda, T. Fujisato, M. Kurihara, Y. Demizu, M. Naito*
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 14 Pages: 2822-2832
- DOI
  10.1021/acschembio.9b00704
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07009, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16K08340
[Journal Article] NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation2019
- Author(s)
  1. Kimura, A., Kitajima, M., Nishida, K., Serada, S., Fujimoto, M., Naka, T., Fuji-Kuriyama, Y., Ito, T., Handa, H., Tanaka, T, Yoshimura, A., Suzuki, H.
- Journal Title
  
  J Exp Med.
  
  Volume: 215 Pages: 2197-2200
- DOI
  10.1084/jem.20172024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08803, KAKENHI-PROJECT-17H06112, KAKENHI-PROJECT-17H04213, KAKENHI-PROJECT-17K08896
[Journal Article] Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor alpha degradation.2018
- Author(s)
  Ohoka Nobumichi、Morita Yoko、Nagai Katsunori、Shimokawa Kenichiro、Ujikawa Osamu、Fujimori Ikuo、Ito Masahiro、Hayase Youji、Okuhira Keiichiro、Shibata Norihito、Hattori Takayuki、Sameshima Tomoya、Sano Osamu、Koyama Ryokichi、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  J Biol Chem
  
  Volume: 293 Pages: 6776-6790
- DOI
  10.1074/jbc.ra117.001091
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase.2018
- Author(s)
  Shibata Norihito、Shimokawa Kenichiro、Nagai Katsunori、Ohoka Nobumichi、Hattori Takayuki、Miyamoto Naoki、Ujikawa Osamu、Sameshima Tomoya、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 13549-13549
- DOI
  10.1038/s41598-018-31913-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Structural basis of thalidomide enantiomer binding to cereblon2018
- Author(s)
  Mori, T., Itoh, T., Liu, S., Ando, H., Sakamoto, S., Yamaguchi, Y., Tokunaga, E., Shibata, N., Handa, H. and Hakoshima, T.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 1294-1294
- DOI
  10.1038/s41598-018-19202-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26251006, KAKENHI-PROJECT-15H04288, KAKENHI-PROJECT-17H04213, KAKENHI-PROJECT-17H06112
[Journal Article] Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs.2016
- Author(s)
  Ito T and Handa H.
- Journal Title
  
  Int J Hematol
  
  Volume: 104 Pages: 293-299
- DOI
  10.1007/s12185-016-2073-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26750374
[Journal Article] Discovery of the target for immunomodulatory drugs (IMiDs)2016
- Author(s)
  伊藤拓水、安藤秀樹、半田宏
- Journal Title
  
  Jpn. J. Clin. Hematol.
  
  Volume: 57 Issue: 5 Pages: 556-562
- DOI
  10.11406/rinketsu.57.556
- NAID
  130005155372
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-26750374
[Journal Article] サリドマイドの標的ユビキチンリガーゼ“セレブロン”とその機能2016
- Author(s)
  伊藤拓水、半田宏
- Journal Title
  
  医学のあゆみ
  
  Volume: 256 Pages: 891-895
- Data Source
  KAKENHI-PROJECT-26750374
[Journal Article] A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.2016
- Author(s)
  Matyskiela ME, Lu G, Ito T, Pagarigan B, Lu CC, Miller K, Fang W, Wang NY, Nguyen D, Houston J, Carmel G, Tran T, Riley M, Nosaka L, Lander GC, Gaidarova S, Xu S, Ruchelman AL, Handa H, Carmichael J, Daniel TO, Cathers BE, Lopez-Girona A, Chamberlain PP.
- Journal Title
  
  Nature
  
  Volume: 535 Pages: 252-257
- DOI
  10.1038/nature18611
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26750374
[Journal Article] 半田ビーズを用いたサリドマイド標的同定2015
- Author(s)
  坂本聡、伊藤拓水、半田宏
- Journal Title
  
  CSJカレントレビュー
  
  Volume: 19 Pages: 86-93
- Data Source
  KAKENHI-PROJECT-26750374
[Journal Article] Another action of a thalidomide derivative.2015
- Author(s)
  Takumi Ito, Hiroshi Handa
- Journal Title
  
  Nature(News & Views)
  
  Volume: 523 Pages: 167-168
- DOI
  10.1038/nature14628
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26750374, KAKENHI-PLANNED-23102002
[Journal Article] Structure of the human cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs.2014
- Author(s)
  P. Chamberlain, A. Lopez-Girona, K. Miller, G. Carmel, B. Pagarigan, B. Chie-Leon, E. Rychak, L. Corral, Y. Ren, M. Wang, M. Riley, S. Delker, T. Ito, H. Ando, T. Mori, Y. Hirano, H. Handa, T. Hakoshima, T. Daniel, B. Cathers
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: 21 Pages: 803-809
- DOI
  10.1038/nsmb.2874
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102002, KAKENHI-PROJECT-24241043, KAKENHI-PROJECT-25440025, KAKENHI-PROJECT-26750374
[Journal Article] Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4CRBN2014
- Author(s)
  A. K. Gandhi, J. Kang, C. G. Havens, T. Conklin, Y. Ning, L. Wu, T. Ito, H. Ando, M. F. Waldman, A. Thakurta, A. Klippel, H. Handa, T.O. Daniel, P. H. Schafer, R. Chopra
- Journal Title
  
  British Journal of Haematology
  
  Volume: 164 Pages: 811-821
- DOI
  10.1111/bjh.12708
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102002, KAKENHI-PROJECT-23710267, KAKENHI-PROJECT-24241043
[Journal Article] セレブロン～IMiDsの標的因子～2013
- Author(s)
  安藤秀樹、伊藤拓水、半田宏
- Journal Title
  
  血液フロンティア
  
  Volume: 23 Pages: 1288-1292
- Data Source
  KAKENHI-PROJECT-23710267
[Journal Article] Vesnarinone suppresses TNFalpha mRNA expression by inhibiting valosin-containing protein.2013
- Author(s)
  Hotta K, Nashimoto A, Yasumura E, Suzuki M, Azuma M, Iizumi Y, Shima D, Nabeshima R, Hiramoto M, Okada A, Sakata-Sogawa K, Tokunaga M, Ito T, Ando H, Sakamoto S, Kabe Y, Aizawa S, Imai T, Yamaguchi Y, Watanabe H, Handa H
- Journal Title
  
  Mol. Pharmacol.
  
  Volume: Vol.83 Pages: 11-15
- DOI
  10.1124/mol.112.081935
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20114004, KAKENHI-PLANNED-23102004, KAKENHI-PROJECT-23570172, KAKENHI-PROJECT-23689036, KAKENHI-PROJECT-23710267, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118002, KAKENHI-PROJECT-24650231, KAKENHI-PLANNED-23102002, KAKENHI-PLANNED-24118006
[Journal Article] セレブロン～IMiDsの標的因子～2013
- Author(s)
  安藤秀樹、伊藤拓水、半田宏
- Journal Title
  
  血液フロンティア, 医薬ジャーナル社
  
  Volume: Vol.23 No.9 Pages: 1288-1292
- Data Source
  KAKENHI-PROJECT-23710267
[Journal Article] サリドマイドの悲劇：その後の研究2013
- Author(s)
  伊藤拓水、安藤秀樹、半田　宏
- Journal Title
  
  キラル化学 -その起源から最新のキラル材料研究まで- CSJカレントレビュー
  
  Volume: 13 Pages: 180-182
- Data Source
  KAKENHI-PROJECT-23710267
[Journal Article] トピックス : サリドマイドの悲劇-その後の研究2013
- Author(s)
  伊藤拓水、安藤秀樹、半田宏
- Journal Title
  
  キラル化学 -その起源から最新のキラル材料研究まで-CSJカレントレビュー
  
  Volume: 第13号 Pages: 180-182
- Data Source
  KAKENHI-PROJECT-23710267
[Journal Article] Tools and methodologies capable of isolating and identifying a target molecule for a bioactive compound.2012
- Author(s)
  Sakamoto, S., Hatakeyama, M., Ito, T. and Handa, H.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 20 Pages: 1990-2001
- DOI
  10.1016/j.bmc.2011.12.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710267, KAKENHI-PLANNED-23102002
[Journal Article] サリドマイド・IMiDsの作用とユビキチンリガーゼ2012
- Author(s)
  伊藤拓水、半田宏
- Journal Title
  
  医学のあゆみ, 医歯薬出版株式会社
  
  Volume: Vol.243 No.6 Pages: 503-507
- Data Source
  KAKENHI-PROJECT-23710267
[Journal Article] Deciphering the mystery of thalidomide teratogenicity.2012
- Author(s)
  Ito, T. and Handa, H.
- Journal Title
  
  Congenital Anomalies
  
  Volume: 52 Issue: 1 Pages: 1-7
- DOI
  10.1111/j.1741-4520.2011.00351.x
- ISSN
  0914-3505
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710267, KAKENHI-PLANNED-23102002
[Journal Article] Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of Bisphenol A2012
- Author(s)
  Ito, Y., Ito, T., Karasawa, S., Enomoto, T., Nashimoto, A., Hase, Y., Sakamoto, S., Ito, T., Mimori, T., Matsumoto, Y., Yamaguchi, Y., Handa, H.
- Journal Title
  
  Plos ONE
  
  Volume: 7(12)
- DOI
  10.1371/journal.pone.0050481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689033, KAKENHI-PROJECT-23710267, KAKENHI-PLANNED-23102002, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118002
[Journal Article] IMiDsの標的分子探索研究の進歩2012
- Author(s)
  伊藤拓水、安藤秀樹、半田宏
- Journal Title
  
  血液内科, 科学評論社
  
  Volume: Vol.64 No.4 Pages: 440-445
- Data Source
  KAKENHI-PROJECT-23710267
[Journal Article] Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide2012
- Author(s)
  Lopez-Girona A, Mendy D, Ito T et al.
- Journal Title
  
  Leukemia
  
  Volume: 26 Pages: 2326-2335
- DOI
  10.1038/leu.2012.119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710267, KAKENHI-PLANNED-23102002
[Journal Article] サリドマイドの催奇性メカニズム2011
- Author(s)
  伊藤拓水、安藤秀樹、半田宏
- Journal Title
  
  化学と生物
  
  Volume: Vol.49, No.12 Pages: 819-824
- NAID
  10030400532
- Data Source
  KAKENHI-PROJECT-23710267
[Patent] METHODS OF USING AN ACTIVATOR OF CEREBLON FOR NEURAL CELL EXPANSION AND THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS2015
- Inventor(s)
  Handa H, Ando H, Ito H
- Industrial Property Rights Holder
  Handa H, Ando H, Ito H
- Industrial Property Rights Type
  特許
- Filing Date
  2015-02-23
- Acquisition Date
  2015-08-27
- Overseas
- Data Source
  KAKENHI-PROJECT-26750374
[Presentation] Targeted Protein Degradation by Small Molecules2020
- Author(s)
  Mikihiko Naito
- Organizer
  第79回日本癌学会総会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] サリドマイドおよび誘導体の分子機構2020
- Author(s)
  伊藤拓水、半田宏
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Hijacking IAP ubiquitin ligases by SNIPERs to induce protein degradation.2019
- Author(s)
  Mikihiko Naito
- Organizer
  第78回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] A novel strategy for destabilizion of oncogenic fusion protein BCR-ABL to inhibit the growth of chronic myelogenous leukemea2019
- Author(s)
  Norihito Shibata, Nobumichi Ohoka, Mikihiko Naito
- Organizer
  日本薬学会第139年会　国際創薬シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Induced Protein Degradation by Chimeric Small Molecules; Recent Progress and Outlook.2019
- Author(s)
  Mikihiko Naito
- Organizer
  Targeted Protein Degradation forum in Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Development of amphipathic cell-penetrating foldamers for delivery of biomacromolecules2019
- Author(s)
  Misawa T, Ohoka N, Goto C, Oba M, Tanaka M, Naito M, Demizu Y.
- Organizer
  European Symposium on Organic Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] CRBNを標的とする薬剤の分子機構2019
- Author(s)
  伊藤拓水、半田宏
- Organizer
  第19回日本蛋白質科学会年会・第71回日本細胞生物学会大会合同年次大会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] セレブロンを標的とする薬剤の分子機構2019
- Author(s)
  伊藤拓水
- Organizer
  バイオインタラクション研究会第６回ワークショップ
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] セレブロンを標的とする薬剤の分子機構2019
- Author(s)
  伊藤拓水
- Organizer
  バイオインタラクション研究会第６回ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-17H04213
[Presentation] Hijacking IAP ubiquitin ligases by SNIPERs to induce protein degradation.2019
- Author(s)
  Mikihiko Naito
- Organizer
  Symposium on Frontier in PROTAC Drug Discovery and Development
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Cereblon modulators2019
- Author(s)
  Takumi Ito
- Organizer
  RIKEN Epigenetics in Wako 2019
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] セレブロンモジュレーターの分子機構2019
- Author(s)
  伊藤拓水、半田宏
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] SNIPERs: Hijacking IAP Ubiquitin Ligases for Targeted Protein Degradation2019
- Author(s)
  Mikihiko Naito
- Organizer
  2nd Annual Targeted Protein Degradation Summit
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 新規セレブロンモジュレーターの分子機構の解析2018
- Author(s)
  伊藤拓水、半田宏
- Organizer
  第41回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H04213
[Presentation] Derivatization of IAP ligand to develop SNIPERs with improved protein knockdown and antitumor activity2018
- Author(s)
  Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori, Mikihiko Naito
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Inducing target-specific protein degradation by SNIPER compounds recruiting IAP ubiquitin ligases2018
- Author(s)
  Mikihiko Naito
- Organizer
  第41回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] セレブロンモジュレーターによるユビキチンリガーゼ制御工学2018
- Author(s)
  伊藤拓水、　半田宏
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04213
[Presentation] 新規セレブロンモジュレーターの分子機構の解析2018
- Author(s)
  伊藤拓水、半田宏
- Organizer
  第41回分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Development of Protein Knockdown Technology to Induce Selective Degradation of Target Proteins2018
- Author(s)
  Mikihiko Naito
- Organizer
  薬物動態懇話会第41回年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinases2018
- Author(s)
  Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Recent Advances in Bifunctional Degrader Molecules (e.g. SNIPER) for Targeted Protein Degradation via the Ubiquitin Proteasome System; Status and Outlook2018
- Author(s)
  Mikihiko Naito
- Organizer
  EFMC-ISMC 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Ligand-directed degradation of GSPT1 by a novel cereblon modulator drives potent antitumor effects2017
- Author(s)
  Matyskiela M, Lu G, Ito T, Pagarigan B, Lu CC, Miller K, Fang W, Wang NY, Nguyen D, Houston J, Carmel G, Tran T, Riley M, Nosaka L, Lander G, Gaidarova S, Xu S, Ruchelman A, Handa H, Carmichale J, Daniel TO, Cathers BE, Lopez-Girona A and Chamberlain P
- Organizer
  AACR Annual Meeting 2017
- Data Source
  KAKENHI-PROJECT-17H04213
[Presentation] リガンド依存的ユビキチンリガーゼCRBNの制御機構2016
- Author(s)
  伊藤拓水、朝妻知子、山本淳一、安藤秀樹、佐藤智美、山口雄輝、半田宏
- Organizer
  日本ケミカルバイオロジー学会第11回年会
- Place of Presentation
  京都テルサ, 京都
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-26750374
[Presentation] 急性骨髄性白血病に有効な新規セレブロンモジュレーターの開発2016
- Author(s)
  伊藤拓水、半田宏
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター、仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26750374
[Presentation] 急性骨髄性白血病に効果を示す新規のセレブロンモジュレーター2016
- Author(s)
  伊藤拓水、半田宏
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26750374
[Presentation] Cereblon is a substrate receptor of the Cul4 ubiquitin ligase whose substrate recognition is modulated by IMiDs.2014
- Author(s)
  伊藤拓水、安藤秀樹、山口雄輝、半田宏
- Organizer
  Cold Spring Harbor Asia - Protein Modification & Homeostasis conference
- Place of Presentation
  蘇州、中国
- Year and Date
  2014-06-18
- Invited
- Data Source
  KAKENHI-PROJECT-26750374
[Presentation] Cereblon is a substrate receptor of the Cul4 ubiquitin ligase whose substrate recognition is modulated by IMiDs.2014
- Author(s)
  伊藤拓水、安藤秀樹、山口雄輝、半田宏
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜、神奈川
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-26750374
[Presentation] サリドマイド類似薬の分子機構ー最新の知見2014
- Author(s)
  伊藤　拓水
- Organizer
  次世代型がん研究戦略セミナー
- Place of Presentation
  東京医科大学教育研究棟、東京
- Invited
- Data Source
  KAKENHI-PROJECT-23710267
[Presentation] サリドマイド標的因子セレブロン : その発見から最新の知見まで2012
- Author(s)
  伊藤拓水、半田宏
- Organizer
  第23回生殖・発生毒性学東京セミナー
- Place of Presentation
  独立行政法人国立オリンピック記念青少年総合センター
- Year and Date
  2012-10-05
- Invited
- Data Source
  KAKENHI-PROJECT-23710267
[Presentation] サリドマイドによる催奇形性の分子機構2011
- Author(s)
  伊藤拓水、安藤秀樹、山口雄輝、半田宏
- Organizer
  第29回日本骨代謝学会学術集会(招待講演)
- Place of Presentation
  大阪国際会議場（グランキューブ大阪）
- Data Source
  KAKENHI-PROJECT-23710267
[Presentation] サリドマイドによる催奇形性の分子機構2011
- Author(s)
  伊藤拓水、安藤秀樹、山口雄輝、半田宏
- Organizer
  第29回日本骨代謝学会学術集会
- Place of Presentation
  大阪国際会議場(グランキューブ大阪)
- Year and Date
  2011-07-30
- Invited
- Data Source
  KAKENHI-PROJECT-23710267
[Presentation] サリドマイド抗がん作用におけるターゲット分子Cereblon
- Author(s)
  伊藤拓水, ティプランパイタンマモングッド, 唐澤慧記, 坂田未希, 舩造正英, 若林知伸, 飯田結, 山口雄輝, 半田宏
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-23710267
[Presentation] サリドマイド標的因子セレブロン：その発見から最新の知見まで
- Author(s)
  伊藤拓水、半田宏
- Organizer
  第23 回生殖・発生毒性学東京セミナー
- Place of Presentation
  独立行政法人国立オリンピック記念青少年総合センター
- Invited
- Data Source
  KAKENHI-PROJECT-23710267

1. 内藤幹彦 (00198011)

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35. 清水誠之

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36. 栗原正明

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37. 北島雅之

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38. 北泰行

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Ito Takumi 伊藤 拓水

ITO Takumi 伊藤 拓水

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Elucidation of the therapeutic mechanisms of IMiDsPrincipal Investigator

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Chemical protein knockdown technology and cell regulation

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Elucidation of the molecular basis of IMiDs' actionPrincipal Investigator

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Elucidation of the molecular mechanism of the anti-cancer activity of IMiDsPrincipal Investigator

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Analysis of thalidomide induced CRBN-E3-ubiquitin-ligase inhibition mechanismPrincipal Investigator

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[Book] "Chapter 16， Protein degradation inducers SNIPERs and PROTACs against oncogenic proteins, In Pharmaceutical Biocatalysis Fundamentals, Enzyme Inhibitors, and Enzymes in Health and Diseases"2019

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[Book] Development of a new affinity nanobead technology and target isolatioin of bioactive compounds2018

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[Book] IMiDs（免疫調整薬）の現状と展望2015

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[Book] 日本臨牀（特集：多発性骨髄腫の病態と最新治療―基礎と臨床の最新情報ー2015

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[Book] 生物活性分子の標的同定と機能解明（CSJカレントビュー第19号）2015

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[Book] Organ Biology 21巻２号2014

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[Journal Article] TRIP12 promotes small molecule-induced degradation of BRD4 through K29/K48 branched ubiquitin chains.2021

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[Journal Article] Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer2021

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[Journal Article] Gluing Proteins for Targeted Degradation2021

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Ito Takumi 伊藤拓水

ITO Takumi 伊藤拓水