TAKAKU Motoki 高久誉大

Researcher Number	30547071
Other IDs
Affiliation (based on the past Project Information) *help	2012: 早稲田大学, 理工学術院, 次席研究員(研究院講師) 2011: 早稲田大学, 理工学術院, 助教 2009 – 2010: Waseda University, 理工学術院, 助手
Review Section/Research Field	Principal Investigator Genetics/Genome dynamics / Genome biology
Keywords	Principal Investigator ゲノム構築・機能・維持 / タンパク質と酵素 / 核酸 / 遺伝子及び染色体 / ゲノム維持修復 / 相同組換え / ゲノム安定性維持 / DNA修復 / クロマチン構造 / RAD51 / 相同組換え修復 / RAD54 / ヌクレオソーム

Functional analysis of RAD51 on nucleosomal DNA templatesPrincipal Investigator
- Principal Investigator
  
  TAKAKU Motoki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Genome biology
- Research Institution
  Waseda University
Functional analysis of a novel RAD51-binding protein, EVL in the homologous recombinational repairPrincipal Investigator
- Principal Investigator
  
  TAKAKU Motoki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Genetics/Genome dynamics
- Research Institution
  Waseda University

All 2013 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] Vertebrate Spt2 is a novel nucleolar histone chaperone that assists in ribosomal DNA transcription2013
- Author(s)
  Osakabe A, Tachiwana H, Takaku M, Hori T, Obuse C, Kimura H, Fukagawa T, Kurumizaka H
- Journal Title
  
  Journal of Cell Science
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23710221
[Journal Article] Human PSF concentrates DNA and stimulates duplex capture in DMC1-mediated homologous nairing2012
- Author(s)
  Morozumi Y, et al
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 40 Pages: 3031-3041
- DOI
  10.1093/nar/gkr1229
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062004, KAKENHI-ORGANIZER-20114001, KAKENHI-PUBLICLY-22019018, KAKENHI-PUBLICLY-23114706, KAKENHI-PROJECT-23710221
[Journal Article] Biochemical analysis of the human Ena/Vasp- family proteins, MENA, VASP, and EVL, in homologous recombination2011
- Author(s)
  Motoki Takaku , Hiroyuki Ueno, Hitoshi Kurumizaka
- Journal Title
  
  The Journal of Biochemistry (in press)
- NAID
  10030585933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870037
[Journal Article] Purification of the human SMN-GEMIN2 complex and assessment of its stimulation of RAD51-mediated DNA rscombination reactions2011
- Author(s)
  Motoki Takaku, Takashi Tsujita, Naoki Horikoshi, Yoshimasa Takizawa, Yong, Qing, Kouji Hirota, Masae Ikura, Tsuyoshi Ikura, Shunichi Takeda, Hitoshi Kurumizaka
- Journal Title
  
  Biochemistry
  
  Volume: 50 Pages: 6797-6805
- DOI
  10.1021/bi200828g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06154, KAKENHI-PROJECT-22310119, KAKENHI-PROJECT-22687001, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23221006, KAKENHI-PROJECT-23710221
[Journal Article] Biochemical analysis of the human ENA/VASP-family proteins, MENA, VASP and EVL, in homologous recombination2011
- Author(s)
  Takaku, M., Ueno, H., Kurumizaka, H.
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 149 Pages: 721-729
- DOI
  10.1093/jb/mvr029
- NAID
  10030585933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310119, KAKENHI-PROJECT-23710221
[Journal Article] Halenaquinone, a chemical compound that specifically inhibits the secondary DNA binding of RAD51.2011
- Author(s)
  Takaku M, Kainuma T, Ishida-Takaku T, Ishigami S, Suzuki H, Tashiro S, van Soest RWM, Nakao Y, Kurumizaka H
- Journal Title
  
  Genes to Cells
  
  Volume: 6 Pages: 427-36
- DOI
  10.1111/j.1365-2443.2011.01494.x
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-20114001, KAKENHI-PROJECT-22310036, KAKENHI-PUBLICLY-23114716, KAKENHI-PROJECT-23650588, KAKENHI-PROJECT-23710221
[Journal Article] Halenaquinone a chemical compound that specifically inhibits the secondary DNA binding of RAD512011
- Author(s)
  Motoki Takaku, Takashi Kainuma, Takako Ishida-Takaku, Shintaro Ishigami, Hidekazu Suzuki, Satoshi Tashiro, Rob W.M.van Soest, Yoichi Nakao, Hitoshi Kurumizaka
- Journal Title
  
  Genes to Cells Vol.16
  
  Pages: 427-436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870037
[Journal Article] Halenaquinone a chemical compound that specifically inhibits the secondary DNA binding of RAD512011
- Author(s)
  Motoki Takaku, Takashi Kainuma, Takako Ishida-Takaku, et al.
- Journal Title
  
  Genes to Cells
  
  Volume: 16 Pages: 427-436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870037
[Journal Article] Holliday junction binding activity of human SPF452010
- Author(s)
  Naoki Horikoshi, Yuichi Morozumi, Motoki Takaku, Yoshimasa Takizawa, Hitoshi Kurumizaka
- Journal Title
  
  Genes to Cells Vol.15
  
  Pages: 373-383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870037
[Journal Article] GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination2010
- Author(s)
  Yoshimasa Takizawa, Yong Qing, Motoki Takaku, et al.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 38 Pages: 5059-5074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870037
[Journal Article] Holliday junction binding activity of human SPF452010
- Author(s)
  Naoki Horikoshi, Yuichi Morozumi, Motoki Takaku, et al.
- Journal Title
  
  Genes to Cells
  
  Volume: 15 Pages: 373-383
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870037
[Journal Article] GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination2010
- Author(s)
  Yoshimasa Takizawa, Yong Qing, Motoki Takaku, Takako Ishida, Yuichi Morozumi, Takashi Tsujita, Toshiaki Kogame, Kouji Hirota, Masayuki Takahashi, Takehiko Shibata, Hitoshi Kurumizaka, Shunichi Takeda
- Journal Title
  
  Nucleic Acids Research Vol.38
  
  Pages: 5059-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870037
[Journal Article] Single-stranded DNA catenation mediated by human EVL and a type I topoisomerase2010
- Author(s)
  Motoki Takaku, Daisuke Takahashi, Shinichi Machida, Hiroyuki Ueno, Noriko Hosoya, Shukuko Ikawa, Kiyoshi Miyagawa, Takehiko Shibata, Hitoshi Kurumizaka
- Journal Title
  
  Nucleic Acids Research Vol.38
  
  Pages: 3959-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870037
[Journal Article] Single-stranded DNA catenation mediated by human EVL and a type I topoisomerase2010
- Author(s)
  Motoki Takaku, Daisuke Takahashi, Shinichi Machida., et al.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 38 Pages: 3959-3968
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870037
[Journal Article] Recombination activator function of the novel RAD51- and RAD51B-binding protein, human EVL2009
- Author(s)
  Motoki Takaku, Shinichi Machida, Noriko Hosoya, …, Hitoshi Kurumizaka
- Journal Title
  
  The Journal of Biological Chemistry 284
  
  Pages: 14326-14336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870037
[Journal Article] Human PSF binds to RAD51 and modulates its homologous-pairing and strandexchange activities2009
- Author(s)
  Yuichi Morozumi, Yoshimasa Takizawa, Motoki Takaku, Hitoshi Kurumizaka
- Journal Title
  
  Nucleic Acids Research Vol.37
  
  Pages: 4296-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870037
[Journal Article] Biochemical analysis of the human EVL domains in homologous recombination2009
- Author(s)
  Motoki Takaku, Shinichi Machida, …, Hitoshi Kurumizaka
- Journal Title
  
  The FEBS journal 276
  
  Pages: 5841-5848
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870037
[Journal Article] Recombination activator function of the novel RAD51- and RAD51B-binding protein, human EVL2009
- Author(s)
  Motoki Takaku, Shinichi Machida, Noriko Hosoya, Shugo Nakayama, Yoshimasa Takizawa, Isao Sakane, Takehiko Shibata, Kiyoshi Miyagawa, Hitoshi Kurumizaka
- Journal Title
  
  The Journal of Biological Chemistry Vol.284
  
  Pages: 14326-14336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870037
[Journal Article] The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction2009
- Author(s)
  Mari Katsura, Takanori Tsuruga, Osamu Date, Takashi Yoshihara, Mari Ishida, Yoshitaka Tomoda, Miyuki Okajima, Motoki Takaku, Hitoshi Kurumizaka, Aiko Kinomura, Hiromu K. Mishima, Kiyoshi Miyagawa
- Journal Title
  
  Nucleic Acids Research Vol.37
  
  Pages: 3959-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870037
[Journal Article] Human PSF binds to RAD51 and modulates its homologous-pairing and strand-exchange activities2009
- Author(s)
  Yuichi Morozumi, Yoshimasa Takizawa, Motoki Takaku, Hitoshi Kurumizaka
- Journal Title
  
  Nucleic Acids Research 37
  
  Pages: 4296-4307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870037
[Journal Article] The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction2009
- Author(s)
  Mari Katsura, …, Motoki Takaku, …, Kiyoshi Miyagawa
- Journal Title
  
  Nucleic Acids Research 37
  
  Pages: 3959-3968
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870037
[Journal Article] Biochemical analysis of the human EVL domains in homologous recombination2009
- Author(s)
  Motoki Takaku, Shinichi Machida, Shugo Nakayama, Daisuke Takahashi, Hitoshi Kurumizaka
- Journal Title
  
  The FEBS journal Vol.276
  
  Pages: 5841-5848
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21870037
[Presentation] Biochemical analyses of homologous recombination reaction in chromatin2012
- Author(s)
  Motoki Takaku
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23710221
[Presentation] Mechanism of the RAD51-mediated homology search on nucleosomal DNA2012
- Author(s)
  Motoki Takaku, Shinichi Machida, Wataru Kobayashi, Naoki Horikoshi, Wataru Kagawa, Hitoshi Kurumizaka
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23710221
[Presentation] Biochemical analyses of homologous recombination reaction in chromatin2012
- Author(s)
  Motoki Takaku, Hitoshi Kurumizaka
- Organizer
  第71回日本癌学会学術総会,
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23710221
[Presentation] Biochemical studies of homologous pairing on chromatinized DNA2012
- Author(s)
  Motoki Takaku, Shinichi Machida, Wataru Kobayashi, Ryota Hayashida, Hidekazu Suzuki, Masae Ikura, Akihisa Osakabe, Hiroaki Tachiwana, Satoshi Tashiro, Tsuyoshi Ikura, and Hitoshi Kurumizaka
- Organizer
  The 8th 3R Symposium
- Place of Presentation
  淡路島
- Data Source
  KAKENHI-PROJECT-23710221
[Presentation] 再構成系によるクロマチンでの相同組換え機構の解析2012
- Author(s)
  高久誉大, 町田晋一, 小林航, 林田亮太, 鈴木秀和, 井倉正枝, 越阪部晃永, 立和名博昭, 浦聖恵, 田代聡, 井倉毅, 胡桃坂仁志
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23710221
[Presentation] SMN-GEMIN2 complex stimulates the RAD51-mediated recombination reactions2011
- Author(s)
  Motoki Takaku, Takashi Tsujita, Naoki Horikoshi, Yoshimasa Takizawa, Yong Qing, Kouji Hirota, Masae Ikura, Tsuyoshi Ikura, Shunichi Takeda, Hitoshi Kurumizaka
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23710221
[Presentation] RAD51活性制御化合物の探索とその生化学的解析2011
- Author(s)
  高久誉大, 海沼嵩, 石田-高久恭子, 石上進太郎, 鈴木秀和, 田代聡, 木村宏,中尾洋一, 胡桃坂仁志
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-23710221
[Presentation] SMN-GEMIN2 complex stimulates the RAD51-mediated recombination reactions2011
- Author(s)
  Motoki Takaku
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23710221
[Presentation] A novel homologous recombination factor, human EVL forms single-stranded DNA catemers with a type I topoisomerase2011
- Author(s)
  Motoki Takaku, Daisuke Takahashi, Shinichi Machida, Hiroyuki Ueno, Hitoshi Kurumizaka
- Organizer
  International Symposium on Physicochemical Field for Genetic Activities
- Place of Presentation
  兵庫県淡路市
- Year and Date
  2011-01-24
- Data Source
  KAKENHI-PROJECT-21870037
[Presentation] RAD51活性制御化合物の探索とその生化学的解析2011
- Author(s)
  高久誉大
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23710221
[Presentation] PLEKHF1 is a novel factor that interacts with the meiosis-specific recombinase, human DMC12011
- Author(s)
  Motoki Takaku, Samika Iwashita, Wataru Kobayashi, Yoshimasa Takizawa, Hitoshi Kurumizaka
- Organizer
  World Congress on Reproductive Biology
- Place of Presentation
  Cairns (Australia)
- Data Source
  KAKENHI-PROJECT-23710221
[Presentation] 新規RAD51活性化因子GEMIN2の相同組換え修復における機能2010
- Author(s)
  高久誉大, 滝沢由政, 辻田幹, 石田恭子, 両角佑一, 胡桃坂仁志
- Organizer
  第9回核ダイナミクス研究会
- Place of Presentation
  静岡県伊豆市
- Data Source
  KAKENHI-PROJECT-21870037
[Presentation] RAD51によるparanemic joint molecule形成過程へのtopoisomerase IIIαの役割2010
- Author(s)
  高久誉大、高橋大介、胡桃坂仁志
- Organizer
  第33回日本分子生物学会年会第83回日本生化学会大会合同大会
- Place of Presentation
  兵庫県神戸市
- Data Source
  KAKENHI-PROJECT-21870037
[Presentation] 新規RAD51組換え活性制御化合物の同定とその作用機序2010
- Author(s)
  石田恭子, 海沼嵩, 高久誉大, 鈴木秀和, 田代聡, 石上進太郎, 他
- Organizer
  第33回日本分子生物学会年会第83回日本生化学会大会合同大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21870037
[Presentation] PSFによるDNA組換え酵素DMC1の活性化2010
- Author(s)
  両角佑一, 高久誉大, 上野裕之, 胡桃坂仁志
- Organizer
  第33回日本分子生物学会年会第83回日本生化学会大会合同大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21870037
[Presentation] RAD51によるparanemic joint molecule形成過程へのtopoisomerase IIIαの役割2010
- Author(s)
  高久誉大, 高橋大介, 胡桃坂仁志
- Organizer
  第33回日本分子生物学会年会第83回日本生化学会大会合同大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21870037
[Presentation] 新規RAD51活性化因子GEMIN2の相同組換え修復における機能2010
- Author(s)
  高久誉大, 滝沢由政, 辻田幹, 石田恭子, 両角佑一, 胡桃坂仁志
- Organizer
  第9回核ダイナミクス研究会
- Place of Presentation
  静岡県伊豆市
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-21870037
[Presentation] RAD51と相互作用するSMN-GEMIN2複合体の生化学的解析2009
- Author(s)
  辻田幹, 高久誉大, 滝沢由政, 胡桃坂仁志
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-21870037
[Presentation] 新規相同組換え修復タンパク質ヒトSPF45の生化学的解析2009
- Author(s)
  堀越直樹, 両角佑一, 高久誉大, 胡桃坂仁志
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-21870037
[Presentation] GEMIN2によるRAD51組換え活性の制御2009
- Author(s)
  高久誉大, 滝沢由政, 辻田幹, 石田恭子, 両角佑一, 胡桃坂仁志
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-21870037
[Presentation] GEMIN2によるRAD51組換え活性の制御2009
- Author(s)
  高久誉大, 滝沢由政, 辻田幹, 石田恭子, 両角佑一, 胡桃坂仁志
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市
- Data Source
  KAKENHI-PROJECT-21870037
[Presentation] 新規RAD51結合タンパク質EVLの機能解析2009
- Author(s)
  高久誉大, 町田晋一, 細谷紀子, 宮川清, 胡桃坂仁志
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  兵庫県神戸市
- Data Source
  KAKENHI-PROJECT-21870037
[Presentation] ヒト相同組換えタンパク質DMC1と相互作用する新規タンパク質PLEKHF1の生化学的機能解析2009
- Author(s)
  岩下紗美香, 高久誉大, 引場樹里, 滝沢由政, 小布施力史, 胡桃坂仁志
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-21870037

1. 武田俊一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 胡桃坂仁志

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

TAKAKU Motoki 高久 誉大

Research Projects

Research Products

Co-Researchers

Functional analysis of RAD51 on nucleosomal DNA templatesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of a novel RAD51-binding protein, EVL in the homologous recombinational repairPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Vertebrate Spt2 is a novel nucleolar histone chaperone that assists in ribosomal DNA transcription2013

Author(s)

Journal Title

Data Source

[Journal Article] Human PSF concentrates DNA and stimulates duplex capture in DMC1-mediated homologous nairing2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biochemical analysis of the human Ena/Vasp- family proteins, MENA, VASP, and EVL, in homologous recombination2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Purification of the human SMN-GEMIN2 complex and assessment of its stimulation of RAD51-mediated DNA rscombination reactions2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biochemical analysis of the human ENA/VASP-family proteins, MENA, VASP and EVL, in homologous recombination2011

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Halenaquinone, a chemical compound that specifically inhibits the secondary DNA binding of RAD51.2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Halenaquinone a chemical compound that specifically inhibits the secondary DNA binding of RAD512011

Author(s)

Journal Title

Data Source

[Journal Article] Halenaquinone a chemical compound that specifically inhibits the secondary DNA binding of RAD512011

Author(s)

Journal Title

Data Source

[Journal Article] Holliday junction binding activity of human SPF452010

Author(s)

Journal Title

Data Source

[Journal Article] GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination2010

Author(s)

Journal Title

Data Source

[Journal Article] Holliday junction binding activity of human SPF452010

Author(s)

Journal Title

Data Source

[Journal Article] GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination2010

Author(s)

Journal Title

Data Source

[Journal Article] Single-stranded DNA catenation mediated by human EVL and a type I topoisomerase2010

Author(s)

Journal Title

Data Source

[Journal Article] Single-stranded DNA catenation mediated by human EVL and a type I topoisomerase2010

Author(s)

Journal Title

Data Source

[Journal Article] Recombination activator function of the novel RAD51- and RAD51B-binding protein, human EVL2009

Author(s)

TAKAKU Motoki 高久誉大