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TAKAKU Motoki  高久 誉大

ORCIDConnect your ORCID iD *help
Researcher Number 30547071
Other IDs
Affiliation (based on the past Project Information) *help 2012: 早稲田大学, 理工学術院, 次席研究員(研究院講師)
2011: 早稲田大学, 理工学術院, 助教
2009 – 2010: Waseda University, 理工学術院, 助手
Review Section/Research Field
Principal Investigator
Genome biology / Genetics/Genome dynamics
Keywords
Principal Investigator
ヌクレオソーム / RAD54 / 相同組換え修復 / RAD51 / クロマチン構造 / DNA修復 / ゲノム安定性維持 / 相同組換え / ゲノム維持修復 / 遺伝子及び染色体 / 核酸 / タンパク質と酵素 / ゲノム構築・機能・維持
  • Research Projects

    (2 results)
  • Research Products

    (45 results)
  • Co-Researchers

    (1 People)
  •  Functional analysis of RAD51 on nucleosomal DNA templatesPrincipal Investigator

    • Principal Investigator
      TAKAKU Motoki
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Genome biology
    • Research Institution
      Waseda University
  •  Functional analysis of a novel RAD51-binding protein, EVL in the homologous recombinational repairPrincipal Investigator

    • Principal Investigator
      TAKAKU Motoki
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Genetics/Genome dynamics
    • Research Institution
      Waseda University

All 2013 2012 2011 2010 2009

All Journal Article Presentation

  • [Journal Article] Vertebrate Spt2 is a novel nucleolar histone chaperone that assists in ribosomal DNA transcription2013

    • Author(s)
      Osakabe A, Tachiwana H, Takaku M, Hori T, Obuse C, Kimura H, Fukagawa T, Kurumizaka H
    • Journal Title

      Journal of Cell Science

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23710221
  • [Journal Article] Biochemical analysis of the human Ena/Vasp- family proteins, MENA, VASP, and EVL, in homologous recombination2011

    • Author(s)
      Motoki Takaku , Hiroyuki Ueno, Hitoshi Kurumizaka
    • Journal Title

      The Journal of Biochemistry (in press)

    • NAID

      10030585933

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Journal Article] Purification of the Human SMN-GEMIN2 Complex and Assessment of Its Stimulation of RAD51-Mediated DNA Recombination Reactions2011

    • Author(s)
      Motoki Takaku, Takashi Tsujita, Naoki Horikoshi, Yoshimasa Takizawa, Yong, Qing, Kouji Hirota, Masae Ikura, Tsuyoshi Ikura, Shunichi Takeda, Hitoshi Kurumizaka
    • Journal Title

      Biochemistry

      Volume: 50 Issue: 32 Pages: 6797-6805

    • DOI

      10.1021/bi200828g

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J06154, KAKENHI-PROJECT-22310119, KAKENHI-PROJECT-22687001, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-23221006, KAKENHI-PROJECT-23710221
  • [Journal Article] Biochemical analysis of the human ENA/VASP-family proteins, MENA, VASP and EVL, in homologous recombination2011

    • Author(s)
      Takaku, M., Ueno, H., Kurumizaka, H.
    • Journal Title

      J.Biochem.

      Volume: 149 Issue: 6 Pages: 721-729

    • DOI

      10.1093/jb/mvr029

    • NAID

      10030585933

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22310119, KAKENHI-PROJECT-23710221
  • [Journal Article] Human PSF concentrates DNA and stimulates duplex capture in DMC1-mediated homologous pairing2011

    • Author(s)
      Morozumi Y, et al
    • Journal Title

      Nucleic Acids Res

      Volume: 40 Issue: 7 Pages: 3031-3041

    • DOI

      10.1093/nar/gkr1229

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20062004, KAKENHI-ORGANIZER-20114001, KAKENHI-PUBLICLY-22019018, KAKENHI-PUBLICLY-23114706, KAKENHI-PROJECT-23710221
  • [Journal Article] Halenaquinone, a chemical compound that specifically inhibits the secondary DNA binding of RAD512011

    • Author(s)
      Takaku M, Kainuma T, Ishida-Takaku T, Ishigami S, Suzuki H, Tashiro S, van Soest RWM, Nakao Y, Kurumizaka H
    • Journal Title

      Genes Cells

      Volume: 6 Issue: 4 Pages: 427-436

    • DOI

      10.1111/j.1365-2443.2011.01494.x

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-20114001, KAKENHI-PROJECT-22310036, KAKENHI-PUBLICLY-23114716, KAKENHI-PROJECT-23650588, KAKENHI-PROJECT-23710221
  • [Journal Article] Halenaquinone a chemical compound that specifically inhibits the secondary DNA binding of RAD512011

    • Author(s)
      Motoki Takaku, Takashi Kainuma, Takako Ishida-Takaku, Shintaro Ishigami, Hidekazu Suzuki, Satoshi Tashiro, Rob W.M.van Soest, Yoichi Nakao, Hitoshi Kurumizaka
    • Journal Title

      Genes to Cells Vol.16

      Pages: 427-436

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Journal Article] Halenaquinone a chemical compound that specifically inhibits the secondary DNA binding of RAD512011

    • Author(s)
      Motoki Takaku, Takashi Kainuma, Takako Ishida-Takaku, et al.
    • Journal Title

      Genes to Cells

      Volume: 16 Pages: 427-436

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Journal Article] Holliday junction binding activity of human SPF452010

    • Author(s)
      Naoki Horikoshi, Yuichi Morozumi, Motoki Takaku, Yoshimasa Takizawa, Hitoshi Kurumizaka
    • Journal Title

      Genes to Cells Vol.15

      Pages: 373-383

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Journal Article] GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination2010

    • Author(s)
      Yoshimasa Takizawa, Yong Qing, Motoki Takaku, et al.
    • Journal Title

      Nucleic Acids Research

      Volume: 38 Pages: 5059-5074

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Journal Article] Holliday junction binding activity of human SPF452010

    • Author(s)
      Naoki Horikoshi, Yuichi Morozumi, Motoki Takaku, et al.
    • Journal Title

      Genes to Cells

      Volume: 15 Pages: 373-383

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Journal Article] GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination2010

    • Author(s)
      Yoshimasa Takizawa, Yong Qing, Motoki Takaku, Takako Ishida, Yuichi Morozumi, Takashi Tsujita, Toshiaki Kogame, Kouji Hirota, Masayuki Takahashi, Takehiko Shibata, Hitoshi Kurumizaka, Shunichi Takeda
    • Journal Title

      Nucleic Acids Research Vol.38

      Pages: 5059-74

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Journal Article] Single-stranded DNA catenation mediated by human EVL and a type I topoisomerase2010

    • Author(s)
      Motoki Takaku, Daisuke Takahashi, Shinichi Machida, Hiroyuki Ueno, Noriko Hosoya, Shukuko Ikawa, Kiyoshi Miyagawa, Takehiko Shibata, Hitoshi Kurumizaka
    • Journal Title

      Nucleic Acids Research Vol.38

      Pages: 3959-68

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Journal Article] Single-stranded DNA catenation mediated by human EVL and a type I topoisomerase2010

    • Author(s)
      Motoki Takaku, Daisuke Takahashi, Shinichi Machida., et al.
    • Journal Title

      Nucleic Acids Research

      Volume: 38 Pages: 3959-3968

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Journal Article] Recombination activator function of the novel RAD51- and RAD51B-binding protein, human EVL2009

    • Author(s)
      Motoki Takaku, Shinichi Machida, Noriko Hosoya, …, Hitoshi Kurumizaka
    • Journal Title

      The Journal of Biological Chemistry 284

      Pages: 14326-14336

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Journal Article] Human PSF binds to RAD51 and modulates its homologous-pairing and strandexchange activities2009

    • Author(s)
      Yuichi Morozumi, Yoshimasa Takizawa, Motoki Takaku, Hitoshi Kurumizaka
    • Journal Title

      Nucleic Acids Research Vol.37

      Pages: 4296-307

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Journal Article] Biochemical analysis of the human EVL domains in homologous recombination2009

    • Author(s)
      Motoki Takaku, Shinichi Machida, …, Hitoshi Kurumizaka
    • Journal Title

      The FEBS journal 276

      Pages: 5841-5848

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Journal Article] Recombination activator function of the novel RAD51- and RAD51B-binding protein, human EVL2009

    • Author(s)
      Motoki Takaku, Shinichi Machida, Noriko Hosoya, Shugo Nakayama, Yoshimasa Takizawa, Isao Sakane, Takehiko Shibata, Kiyoshi Miyagawa, Hitoshi Kurumizaka
    • Journal Title

      The Journal of Biological Chemistry Vol.284

      Pages: 14326-14336

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Journal Article] The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction2009

    • Author(s)
      Mari Katsura, Takanori Tsuruga, Osamu Date, Takashi Yoshihara, Mari Ishida, Yoshitaka Tomoda, Miyuki Okajima, Motoki Takaku, Hitoshi Kurumizaka, Aiko Kinomura, Hiromu K. Mishima, Kiyoshi Miyagawa
    • Journal Title

      Nucleic Acids Research Vol.37

      Pages: 3959-68

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Journal Article] Human PSF binds to RAD51 and modulates its homologous-pairing and strand-exchange activities2009

    • Author(s)
      Yuichi Morozumi, Yoshimasa Takizawa, Motoki Takaku, Hitoshi Kurumizaka
    • Journal Title

      Nucleic Acids Research 37

      Pages: 4296-4307

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Journal Article] The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction2009

    • Author(s)
      Mari Katsura, …, Motoki Takaku, …, Kiyoshi Miyagawa
    • Journal Title

      Nucleic Acids Research 37

      Pages: 3959-3968

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Journal Article] Biochemical analysis of the human EVL domains in homologous recombination2009

    • Author(s)
      Motoki Takaku, Shinichi Machida, Shugo Nakayama, Daisuke Takahashi, Hitoshi Kurumizaka
    • Journal Title

      The FEBS journal Vol.276

      Pages: 5841-5848

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Presentation] Biochemical analyses of homologous recombination reaction in chromatin2012

    • Author(s)
      Motoki Takaku
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23710221
  • [Presentation] Mechanism of the RAD51-mediated homology search on nucleosomal DNA2012

    • Author(s)
      Motoki Takaku, Shinichi Machida, Wataru Kobayashi, Naoki Horikoshi, Wataru Kagawa, Hitoshi Kurumizaka
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23710221
  • [Presentation] Biochemical analyses of homologous recombination reaction in chromatin2012

    • Author(s)
      Motoki Takaku, Hitoshi Kurumizaka
    • Organizer
      第71回日本癌学会学術総会,
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23710221
  • [Presentation] Biochemical studies of homologous pairing on chromatinized DNA2012

    • Author(s)
      Motoki Takaku, Shinichi Machida, Wataru Kobayashi, Ryota Hayashida, Hidekazu Suzuki, Masae Ikura, Akihisa Osakabe, Hiroaki Tachiwana, Satoshi Tashiro, Tsuyoshi Ikura, and Hitoshi Kurumizaka
    • Organizer
      The 8th 3R Symposium
    • Place of Presentation
      淡路島
    • Data Source
      KAKENHI-PROJECT-23710221
  • [Presentation] 再構成系によるクロマチンでの相同組換え機構の解析2012

    • Author(s)
      高久誉大, 町田晋一, 小林航, 林田亮太, 鈴木秀和, 井倉正枝, 越阪部晃永, 立和名博昭, 浦聖恵, 田代聡, 井倉毅, 胡桃坂仁志
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-23710221
  • [Presentation] SMN-GEMIN2 complex stimulates the RAD51-mediated recombination reactions2011

    • Author(s)
      Motoki Takaku, Takashi Tsujita, Naoki Horikoshi, Yoshimasa Takizawa, Yong Qing, Kouji Hirota, Masae Ikura, Tsuyoshi Ikura, Shunichi Takeda, Hitoshi Kurumizaka
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23710221
  • [Presentation] RAD51活性制御化合物の探索とその生化学的解析2011

    • Author(s)
      高久誉大, 海沼嵩, 石田-高久恭子, 石上進太郎, 鈴木秀和, 田代聡, 木村宏,中尾洋一, 胡桃坂仁志
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-PROJECT-23710221
  • [Presentation] SMN-GEMIN2 complex stimulates the RAD51-mediated recombination reactions2011

    • Author(s)
      Motoki Takaku
    • Organizer
      第34回 日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23710221
  • [Presentation] A novel homologous recombination factor, human EVL forms single-stranded DNA catemers with a type I topoisomerase2011

    • Author(s)
      Motoki Takaku, Daisuke Takahashi, Shinichi Machida, Hiroyuki Ueno, Hitoshi Kurumizaka
    • Organizer
      International Symposium on Physicochemical Field for Genetic Activities
    • Place of Presentation
      兵庫県淡路市
    • Year and Date
      2011-01-24
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Presentation] RAD51活性制御化合物の探索とその生化学的解析2011

    • Author(s)
      高久 誉大
    • Organizer
      第84回 日本生化学会大会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23710221
  • [Presentation] PLEKHF1 is a novel factor that interacts with the meiosis-specific recombinase, human DMC12011

    • Author(s)
      Motoki Takaku, Samika Iwashita, Wataru Kobayashi, Yoshimasa Takizawa, Hitoshi Kurumizaka
    • Organizer
      World Congress on Reproductive Biology
    • Place of Presentation
      Cairns (Australia)
    • Data Source
      KAKENHI-PROJECT-23710221
  • [Presentation] 新規RAD51活性化因子GEMIN2の相同組換え修復における機能2010

    • Author(s)
      高久誉大, 滝沢由政, 辻田幹, 石田恭子, 両角佑一, 胡桃坂仁志
    • Organizer
      第9回核ダイナミクス研究会
    • Place of Presentation
      静岡県伊豆市
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Presentation] RAD51によるparanemic joint molecule形成過程へのtopoisomerase IIIαの役割2010

    • Author(s)
      高久誉大、高橋大介、胡桃坂仁志
    • Organizer
      第33回日本分子生物学会年会 第83回日本生化学会大会合同大会
    • Place of Presentation
      兵庫県神戸市
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Presentation] 新規RAD51組換え活性制御化合物の同定とその作用機序2010

    • Author(s)
      石田恭子, 海沼嵩, 高久誉大, 鈴木秀和, 田代聡, 石上進太郎, 他
    • Organizer
      第33回 日本分子生物学会年会 第83回 日本生化学会大会 合同大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Presentation] PSFによるDNA組換え酵素DMC1の活性化2010

    • Author(s)
      両角佑一, 高久誉大, 上野裕之, 胡桃坂仁志
    • Organizer
      第33回 日本分子生物学会年会 第83回 日本生化学会大会 合同大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Presentation] RAD51によるparanemic joint molecule形成過程へのtopoisomerase IIIαの役割2010

    • Author(s)
      高久誉大, 高橋大介, 胡桃坂仁志
    • Organizer
      第33回 日本分子生物学会年会 第83回 日本生化学会大会 合同大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Presentation] 新規RAD51活性化因子GEMIN2の相同組換え修復における機能2010

    • Author(s)
      高久誉大, 滝沢由政, 辻田幹, 石田恭子, 両角佑一, 胡桃坂仁志
    • Organizer
      第9回 核ダイナミクス研究会
    • Place of Presentation
      静岡県伊豆市
    • Year and Date
      2010-05-27
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Presentation] RAD51と相互作用するSMN-GEMIN2複合体の生化学的解析2009

    • Author(s)
      辻田幹, 高久誉大, 滝沢由政, 胡桃坂仁志
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      神奈川県 横浜市
    • Year and Date
      2009-12-12
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Presentation] 新規相同組換え修復タンパク質ヒトSPF45の生化学的解析2009

    • Author(s)
      堀越直樹, 両角佑一, 高久誉大, 胡桃坂仁志
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      神奈川県 横浜市
    • Year and Date
      2009-12-12
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Presentation] GEMIN2によるRAD51組換え活性の制御2009

    • Author(s)
      高久誉大, 滝沢由政, 辻田幹, 石田恭子, 両角佑一, 胡桃坂仁志
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      神奈川県 横浜市
    • Year and Date
      2009-12-11
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Presentation] GEMIN2によるRAD51組換え活性の制御2009

    • Author(s)
      高久誉大, 滝沢由政, 辻田幹, 石田恭子, 両角佑一, 胡桃坂仁志
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Presentation] 新規RAD51結合タンパク質EVLの機能解析2009

    • Author(s)
      高久誉大, 町田晋一, 細谷紀子, 宮川清, 胡桃坂仁志
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫県神戸市
    • Data Source
      KAKENHI-PROJECT-21870037
  • [Presentation] ヒト相同組換えタンパク質DMC1と相互作用する新規タンパク質PLEKHF1の生化学的機能解析2009

    • Author(s)
      岩下紗美香, 高久誉大, 引場樹里, 滝沢由政, 小布施力史, 胡桃坂仁志
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      神奈川県 横浜市
    • Year and Date
      2009-12-11
    • Data Source
      KAKENHI-PROJECT-21870037
  • 1.  胡桃坂 仁志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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