shirakihara takuya 白木原琢哉

… Alternative Names

SHIRAKIHARA Takuya 白木原琢哉

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Researcher Number	30548756
Other IDs	https://orcid.org/0000-0002-6222-0143
Affiliation (Current)	2026: 順天堂大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 順天堂大学, 医学部, 准教授 2021 – 2022: 北里大学, 医学部, 講師 2016 – 2020: 北里大学, 医学部, 助教 2015: 国立研究開発法人国立がん研究センター, 研究所, 研究員 2011 – 2014: 独立行政法人国立がん研究センター, 研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / General medical chemistry / Tumor biology / Experimental pathology Except Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 55020:Digestive surgery-related / Tumor biology
Keywords	Principal Investigator 癌微小環境 / リン酸化タンパク質 / 受容体型チロシンキナーゼ / チロシンリン酸化 / スキルス胃がん / EMT / 転移 / 休眠癌細胞 / 癌関連線維芽細胞 / リン酸化 … More / FGFR2 / 発生・分化 / プロテオーム / シグナル伝達 / 癌 / チロシンキナーゼ / Met / FGF受容体 / リン酸化チロシン / TGF-beta / FGF-2 / TGF-β / 細胞 … More Except Principal Investigator 癌内線維芽細胞 / FOXQ1 / 癌関連線維芽細胞 / 癌微小環境 / 乳癌 / Notchシグナル / 大腸癌 / Flotillin-1 / ＳＨＰ２ / ＡＬＫ / 薬剤感受性 / 分子標的治療薬 / 細胞・組織 / 癌 / Shp2 / Flotillin / チロシンリン酸化 / チロシンキナーゼ / ALK / SHP2 / 神経芽腫 Less

Mechanism of breast cancer cell dormancy regulated by cancer-associated fibroblastsPrincipal Investigator
- Principal Investigator
  
  白木原琢哉
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Juntendo University
癌微小環境によるNotchシグナル活性化と大腸癌悪性化
- Principal Investigator
  
  本庄薫平
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Juntendo University
癌微小環境による乳癌分化転換と治療抵抗性に係る分子メカニズムの解明
- Principal Investigator
  
  渡邉純一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Juntendo University
スキルス胃癌の浸潤や腹膜播種に寄与するチロシンリン酸化蛋白質の解明Principal Investigator
- Principal Investigator
  
  白木原琢哉
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Juntendo University
Identification of phosphoproteins contributing to Epithelial-Mesenchymal Transition.Principal Investigator
- Principal Investigator
  
  Shirakihara Takuya
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kitasato University
Biological roles of ALK-binding molecules in neuroblastoma
- Principal Investigator
  
  Sakai Ryuichi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Kitasato University
  National Cancer Center Japan
Identification and functional analysis of phosphotyrosine proteins in scirrhous gastric cancerPrincipal Investigator
- Principal Investigator
  
  Shirakihara Takuya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  National Cancer Center Japan
Researching the mechanism of cancer-associated epithelial cellsPrincipal Investigator
- Principal Investigator
  
  SHIRAKIHARA Takuya
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  National Cancer Center Japan

All 2024 2022 2021 2019 2018 2017 2016 2015 2013 2011 Other

All Journal Article Presentation

[Journal Article] Activin A from primary breast tumors generates a pre-metastatic niche by inducing pulmonary fibrosis2024
- Author(s)
  Shirakihara T., Orimo A
- Journal Title
  
  Transl Breast Cancer Res.
  
  Volume: 5 Pages: 24-24
- DOI
  10.21037/tbcr-24-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-22K07176
[Journal Article] Transferrin receptor 1 promotes the fibroblast growth factor receptor-mediated oncogenic potential of diffused-type gastric cancer2022
- Author(s)
  Shirakihara Takuya、Yamaguchi Hideki、Kondo Tadashi、Yashiro Masakazu、Sakai Ryuichi
- Journal Title
  
  Oncogene
  
  Volume: 41 Issue: 18 Pages: 2587-2596
- DOI
  10.1038/s41388-022-02270-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07242, KAKENHI-PROJECT-17K08648, KAKENHI-PROJECT-21K07105
[Journal Article] Intracellular cholesterol level regulates sensitivity of glioblastoma cells against temozolomide-induced cell death by modulation of caspase-8 activation via death receptor 5-accumulation and activation in the plasma membrane lipid raft2018
- Author(s)
  Yamamoto Yutaro、Tomiyama Arata、Sasaki Nobuyoshi、Yamaguchi Hideki、Shirakihara Takuya、Nakashima Katsuhiko、Kumagai Kosuke、Takeuchi Satoru、Toyooka Terushige、Otani Naoki、Wada Kojiro、Narita Yoshitaka、Ichimura Koichi、Sakai Ryuichi、Namba Hiroki、Mori Kentaro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 495 Issue: 1 Pages: 1292-1299
- DOI
  10.1016/j.bbrc.2017.11.113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K14616, KAKENHI-PROJECT-26290043, KAKENHI-PROJECT-16K14622, KAKENHI-PROJECT-18K07219
[Journal Article] Augmentation of invadopodia formation in temozolomide-resistant or adopted glioma is regulated by c-Jun terminal kinase-paxillin axis2015
- Author(s)
  Ueno H, Tomiyama A, Yamaguchi H, Uekita T et al.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 468 Issue: 1-2 Pages: 240-247
- DOI
  10.1016/j.bbrc.2015.10.122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06850, KAKENHI-PROJECT-25430126, KAKENHI-PROJECT-25461494, KAKENHI-PROJECT-26290043
[Journal Article] Identification of integrin α3 as a molecular marker of cells undergoing epithelial-mesenchymal transition and of cancer cells with aggressive phenotypes.2013
- Author(s)
  Shirakihara T, Kawasaki T, Fukagawa A, Semba K, Sakai R, Miyazono K, Miyazawa K, Saitoh M.
- Journal Title
  
  Cancer Science
  
  Volume: 104 Issue: 9 Pages: 1189-1197
- DOI
  10.1111/cas.12220
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22112002, KAKENHI-PROJECT-23300353, KAKENHI-PROJECT-24390419, KAKENHI-PROJECT-25830096
[Journal Article] Identification of integrin alpha3, as a molecular maker of cells undergoing EMT and cancer cells with aggressive phenotypes
- Author(s)
  Takuya Shirakihara, Tomonori Kawasaki, Akihito Fukagawa, Kentaro Semba, Ryuichi Sakai, Kohei Miyazono, Keiji Miyazawa, Masao Saitoh
- Journal Title
  
  Cancer Science
  
  Volume: (未掲載)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790455
[Presentation] FGFR2遺伝子増幅型スキルス胃がんの進展に対するTfR1の作用機序について2022
- Author(s)
  白木原琢哉, 堺隆一
- Organizer
  第31回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-22K07176
[Presentation] The role of TfR1 in the progression of FGFR2 gene-amplified scirrhous gastric cancer2022
- Author(s)
  白木原琢哉, 堺隆一
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08648
[Presentation] FGFR2遺伝子増幅型スキルス胃がんの進展に対するTfR1の作用機序について2022
- Author(s)
  白木原琢哉, 堺隆一
- Organizer
  第31回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K08648
[Presentation] The role of TfR1 in the progression of FGFR2 gene-amplified scirrhous gastric cancer2022
- Author(s)
  白木原琢哉, 堺隆一
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07176
[Presentation] Functional analysis of FGFR2 binding target protein in scirrhous gastric cancer2021
- Author(s)
  白木原琢哉
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08648
[Presentation] スキルス胃がんの進展に関わるFGFR2結合タンパク質の機能解析2021
- Author(s)
  白木原琢哉
- Organizer
  第30回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K08648
[Presentation] びまん性胃がんの進展に関わるFGFR2結合タンパク質の探索と機能解析2019
- Author(s)
  白木原琢哉, 堺隆一
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08648
[Presentation] スキルス胃がんの進展に関わるFGF受容体結合タンパク質TfR1の機能解析2019
- Author(s)
  白木原琢哉, 堺隆一
- Organizer
  第28回日本がん転移学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-17K08648
[Presentation] Identification and functional analysis of FGFR2 binding proteins in diffuse-type gastric carcinoma2019
- Author(s)
  Takuya Shirakihara, Ryuichi Sakai
- Organizer
  American Association for Cancer Research Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08648
[Presentation] The effects of FGF signaling on TGF-beta-induced EMT2017
- Author(s)
  Takuya Shirakihara
- Organizer
  8th International EMT Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08648
[Presentation] 神経芽腫におけるShcCを介したSHP2とALKの結合は、神経芽腫細胞の腫瘍原性を制御する2016
- Author(s)
  Arata Tomiyama, Takuya Shirakihara, Katsuhiko Nakashima, Hideki Yamaguchi, Kentaro Mori, Ryuichi Sakai
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26290043
[Presentation] 神経芽腫細胞におけるSHP2とALKの結合は、神経芽腫の腫瘍原性を制御する2015
- Author(s)
  富山新太、上野英明、白木原琢哉、中島克彦、山口英樹、森健太郎、堺隆一
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-26290043
[Presentation] スキルス胃がんにおける活性化受容体結合タンパク質の同定と機能解析2015
- Author(s)
  白木原琢哉, 山口英樹, 堺隆一
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  愛知県名古屋市名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25830096
[Presentation] スキルス胃がんの浸潤・腹膜播種に関与する活性化受容体結合タンパク質の解析2015
- Author(s)
  白木原琢哉, 山口英樹, 堺隆一
- Organizer
  第24回日本がん転移学会学術集会・総会
- Place of Presentation
  大阪府大阪市シティプラザ大阪
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-25830096
[Presentation] FGF-2 accelerates TGF-beta-induced EMT and promotes invasion of cancer2013
- Author(s)
  白木原琢哉、堺隆一、齋藤正夫
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2013-10-03
- Data Source
  KAKENHI-PROJECT-23790455
[Presentation] TGF-beta誘導性EMTの亢進とがん浸潤への関与2013
- Author(s)
  白木原琢哉、齋藤正夫、堺隆一
- Organizer
  第22回日本がん転移学会学術集会・総会
- Place of Presentation
  長野県松本市ホテルブエナビスタ
- Data Source
  KAKENHI-PROJECT-25830096
[Presentation] FGF-2 accelerates TGF-beta-induced epithelial-mesenchymal transition and promotes invasion of cancer2013
- Author(s)
  白木原琢哉、堺隆一、齋藤正夫
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25830096
[Presentation] FGF-2によるTGF-β誘導性EMTの亢進とがん浸潤への関与2013
- Author(s)
  白木原　琢哉
- Organizer
  第22回日本がん転移学会学術集会・総会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-23790455
[Presentation] FGF-2によるTGF-beta誘導性EMTの亢進とがん浸潤への関与2013
- Author(s)
  白木原琢哉、堺隆一、齋藤正夫
- Organizer
  第22回日本がん転移学会学術集会・総会
- Place of Presentation
  松本
- Year and Date
  2013-07-11
- Data Source
  KAKENHI-PROJECT-23790455
[Presentation] FGF-2 accelerates TGF-β-induced epithelial-mesenchymal transition and p romotes invasion of cancer2013
- Author(s)
  白木原　琢哉
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790455
[Presentation] FGF-2 accelerates TGF-beta-induced epithelial-mesenchymal transition and promotes invasion of cancer2013
- Author(s)
  Takuya Shirakihara, Sakai Ryuichi, Masao Saitoh
- Organizer
  Mechanismms & Models of Cancer Symposium 2013
- Place of Presentation
  San Diego (USA)
- Data Source
  KAKENHI-PROJECT-25830096
[Presentation] FGF-2 accelerates TGF-beta-induced EMT and promotes invasion of cancer2013
- Author(s)
  Takuya Shirakihara, Ryuichi Sakai, Masao Saitoh
- Organizer
  The 3^<rd> Symposium Mechanisms and Models of Cancer
- Place of Presentation
  San Diego (USA)
- Year and Date
  2013-08-07
- Data Source
  KAKENHI-PROJECT-23790455
[Presentation] TGF-beta swiches isoform of FGF receptors and regulates EMT of cancer-associated epithelial cells2011
- Author(s)
  Shirakihara T, Miyazono K, Saitoh M
- Organizer
  5th International EMT Meeting
- Place of Presentation
  Biopolis (Singapore)
- Data Source
  KAKENHI-PROJECT-23790455
[Presentation] TGF-beta swiches isoform of FGF receptors and regulates EMT of cancer-associated epithelial cells2011
- Author(s)
  Takuya Shirakihara, Kohei Miyazono, Masao Saitoh
- Organizer
  5^<th> International EMT Meeting
- Place of Presentation
  Biopolis (Singapore)
- Year and Date
  2011-10-11
- Data Source
  KAKENHI-PROJECT-23790455
[Presentation] Involvement of FGF signaling in metastasis and peritoneal dissemination of diffuse gastric cancer
- Author(s)
  白木原琢哉、堺隆一
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25830096
[Presentation] スキルス胃がんの浸潤・腹膜播種へのFGFシグナルの関与
- Author(s)
  白木原琢哉、堺隆一
- Organizer
  第23回日本がん転移学会学術集会・総会
- Place of Presentation
  石川県金沢市金沢ニューグランドホテル
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-25830096

1. 折茂彰 (70275866)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Sakai Ryuichi (40215603)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. 本庄薫平 (10814535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 渡邉純一郎 (40938403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. YAMAGUCHI Hideki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. Tomiyama Arata

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 宮園浩平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 上北尚正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 原めぐみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

shirakihara takuya 白木原 琢哉

SHIRAKIHARA Takuya 白木原 琢哉

Research Projects

Research Products

Co-Researchers

Mechanism of breast cancer cell dormancy regulated by cancer-associated fibroblastsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

癌微小環境によるNotchシグナル活性化と大腸癌悪性化

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

癌微小環境による乳癌分化転換と治療抵抗性に係る分子メカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

スキルス胃癌の浸潤や腹膜播種に寄与するチロシンリン酸化蛋白質の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of phosphoproteins contributing to Epithelial-Mesenchymal Transition.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biological roles of ALK-binding molecules in neuroblastoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and functional analysis of phosphotyrosine proteins in scirrhous gastric cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Researching the mechanism of cancer-associated epithelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Activin A from primary breast tumors generates a pre-metastatic niche by inducing pulmonary fibrosis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transferrin receptor 1 promotes the fibroblast growth factor receptor-mediated oncogenic potential of diffused-type gastric cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intracellular cholesterol level regulates sensitivity of glioblastoma cells against temozolomide-induced cell death by modulation of caspase-8 activation via death receptor 5-accumulation and activation in the plasma membrane lipid raft2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Augmentation of invadopodia formation in temozolomide-resistant or adopted glioma is regulated by c-Jun terminal kinase-paxillin axis2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of integrin α3 as a molecular marker of cells undergoing epithelial-mesenchymal transition and of cancer cells with aggressive phenotypes.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of integrin alpha3, as a molecular maker of cells undergoing EMT and cancer cells with aggressive phenotypes

Author(s)

shirakihara takuya 白木原琢哉

SHIRAKIHARA Takuya 白木原琢哉