UCHIDA Hitoshi 内田仁司

Researcher Number	30549621
External Links
Affiliation *help	2014 – 2018 : 新潟大学, 脳研究所, 助教 2016 : 長崎大学, 医歯薬学総合研究科(薬学系), 助教 2014 : 長崎大学, 医歯薬学総合研究科(薬学系), 助教 2011 : Nagasaki University, 医歯(薬)学総合研究科, その他 2011 : 関西医科大学, 医学部, 特別研究員(PD) … More
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology / 疼痛学 Except Principal Investigator Anesthesiology / Biological Sciences / Pathological medical chemistry / Anesthesiology/Resuscitation studies
Keywords	Principal Investigator 脊髄後根神経節 / 神経障害性疼痛 / エピジェネティクス / 遺伝子発現 / 神経因性疼痛 / ヒストンアセチル化 / リゾホスファチジン酸 / 神経科学 / 転写共役因子 / ADAR … More Except Principal Investigator 脱髄 / 神経障害性疼痛 / リゾホスファチジン酸 / 線維筋痛症 / プロテオーム / 可視化 / エピジェネティクス / 細胞内局在 / NRSF/REST / MAP2 / iPS / プロサイモシンアルファー / LTP / 遺伝子発現 / BDNF / プライミング / in vio再構成 / ex vivo解析 / LPAプライミング / 脊髄後根神経節 / WGAトランスジーン法 / ストレス / 神経因性疹痛 / フィードフォワード機構 / LPA受容体 / 神経因性疼痛 / コルチコステロン / LPA産生 / アストロサイト / iPS細胞 / WGA-EGFP / Mass imaging / スプラウティング / LPA合成酵素 / Eph / KCC2 / 脂質メディエーター / ミエリン蛋白質 / ミクログリア / 脳・神経 / 断続的くり返し精神的ストレス / 慢性疼痛 / 神経発芽 / スパイン / 創薬スクリーニング / Cre-loxP / 脂質 / LPA de novo合成 / アクチン / 脊髄損傷 / NFκBアセチル化 / 神経回路 Less

Elucidation of role of RNA editing in neuropathic painPrincipal InvestigatorOngoing
- Principal Investigator
  
  内田仁司
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Niigata University
Reproduction of chronic pain model through a reconstitution of neuronal circuit components including LPA priming and iPS cells, and its application for drug discovery
- Principal Investigator
  
  UEDA Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Anesthesiology
- Research Institution
  Nagasaki University
Integrative understanding of epigenetic silencing in neuropathic painPrincipal Investigator
- Principal Investigator
  
  Uchida Hitoshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Niigata University
難治性神経因性疼痛を担うエピジェネティクス異常とその調節機構の解明Research Fellow
- Research Fellow
  
  内田仁司
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kansai Medical University
脂質シグナリングによる痛みの記憶化:エピジェネティクス制御機構の解明Principal Investigator
- Principal Investigator
  
  内田仁司
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  疼痛学
- Research Institution
  Nagasaki University
ストレス性精神疾患の可視化とナノメディシン
- Principal Investigator
  
  植田弘師
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Identification of molecular targets to cure intractable neuropathic pain with nerve injury-induced demyelination
- Principal Investigator
  
  UEDA Hiroshi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Nagasaki University

All 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Epigenetic modification in neuropathic pain2015
- Author(s)
  Hiroshi Ueda and Hitoshi Uchida
- Journal Title
  
  Current Pharmaceutical Design
  
  Volume : 21 Pages : 849-867
- DOI
  10.2174/1381612820666141027113923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26830048
[Journal Article] Donepezil reverses intermittent stress-induced generalized chronic pain syndrome in mice2015
- Author(s)
  Mukae T, Uchida H,Ueda H
- Journal Title
  
  JPET
  
  Volume : 353 Pages : 471-479
- DOI
  10.1124/jpet.114.222414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253077
[Journal Article] Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury2015
- Author(s)
  Uchida H, Matsushita Y,　Araki K, Mukae T,Ueda H
- Journal Title
  
  J Pharmacol Sci
  
  Volume : 128（4） Pages : 208-211
- DOI
  10.1016/j.jphs.2015.07.040
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253077, KAKENHI-PROJECT-26830048
[Journal Article] Epigenetic Modification in Neuropathic Pain.2015
- Author(s)
  Ueda H,Uchida H
- Journal Title
  
  Curr Pharm Des
  
  Volume : .21(7) Pages : 849-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253077
[Journal Article] Identification of nitrated tyrosine residues of protein kinase G-Iα by mass spectrometry2014
- Author(s)
  Lu J, Yao I, Shimojo M, Katano T, Uchida H, Setou M, Ito S
- Journal Title
  
  Anal Bioanal Chem
  
  Volume : 406 Pages : 1387-1396
- DOI
  10.1007/s00216-013-7535-4
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-11J09224, KAKENHI-PROJECT-23689021, KAKENHI-PUBLICLY-24111547, KAKENHI-PROJECT-24300110, KAKENHI-PROJECT-25293137, KAKENHI-PROJECT-25460729, KAKENHI-PROJECT-26670291
[Journal Article] Lysophosphatidic acid and its receptors LPA1 and LPA3 mediate paclitaxel-induced neuropathic pain in mice2014
- Author(s)
  Uchida H, Nagai J, Ueda H
- Journal Title
  
  Molecular Pain
  
  Volume : 10:71 Pages : 1-7
- DOI
  10.1186/1744-8069-10-71
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26253077, KAKENHI-PROJECT-26830048, KAKENHI-PROJECT-26860383
[Journal Article] 痛みによるepigenetic修飾2014
- Author(s)
  植田弘師、内田仁司
- Journal Title
  
  脳21 17(2)23-27(2014)
  
  Volume : 17（2） Pages : 23-27
- Data Source
  KAKENHI-PROJECT-26253077
[Journal Article] Epigenetic regulation of BDNF expression in the primary sensoryneurons after peripheral nerve injury: Implications in the development of neuropathic pain.2013
- Author(s)
  Uchida H, Matsushita Y, Ueda H
- Journal Title
  
  Neuroscience
  
  Volume : 240 Pages : 147-154
- DOI
  10.1016/j.neuroscience.2013.02.053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J09224, KAKENHI-PUBLICLY-23116513
[Journal Article] Evidence for De Novo Synthesis of Lysophosphatidic Acid in the Spinal Cord through Phospholipase A2 and Autotaxin in Nerve Injury-induced Neuropathic Pain.2010
- Author(s)
  Ma L, Uchida H, Nagai J, Inoue M, Aoki J, Ueda H.
- Journal Title
  
  J Pharmacol Exp Ther. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain.2010
- Author(s)
  Uchida H, Ma L, Ueda H.
- Journal Title
  
  J Neurosci 30(13)
  
  Pages : 4806-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Neuron-restrictive silencer factor causes epigenetic silencing of Kv4. 3 gene after peripheral nerve injury.2010
- Author(s)
  Uchida H, Sasaki K, Ma L, Ueda H.
- Journal Title
  
  Neuroscience 166(1)
  
  Pages : 1-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Neuron-restrictive silencer factor causes epigenetic silencing of Kv4.3 gene after peripheral nerve injury2010
- Author(s)
  Hitoshi Uchida
- Journal Title
  
  Neuroscience 166
  
  Pages : 1-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain2010
- Author(s)
  Hitoshi Uchida
- Journal Title
  
  The Journal of Neuroscience (In press)(掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023022
[Journal Article] Neuron-restrictive silencer factor causes epigenetic silencing of Kv4.3 gene after peripheral nerve injury2010
- Author(s)
  Hitoshi Uchida
- Journal Title
  
  Neuroscience 166
  
  Pages : 1-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023022
[Journal Article] Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain2010
- Author(s)
  Hitoshi Uchida
- Journal Title
  
  The Journal of Neuroscience (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain.2009
- Author(s)
  Ma L, Uchida H, Nagai J, Inoue M, Chun J, Aoki J, Ueda H.
- Journal Title
  
  Mol Pain 5
  
  Pages : 64-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Profiling of BoNT/C3-reversible gene expression induced by lysophosphatidic acid:ephrinB1 gene up-regulation underlying neuropathic hyperalgesia and allodynia.2009
- Author(s)
  Uchida H, Matsumoto M, Ueda H.
- Journal Title
  
  Neurochem Int 54(3-4)
  
  Pages : 215-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Profiling of BoNT/C3-reversible gene expression induced by lysophosphatidic acid : ephrinB1 gene up-regulation underlying neuropathic hyperalgesia and allodynia2009
- Author(s)
  Hitoshi Uchida
- Journal Title
  
  Neurochemistry International 54
  
  Pages : 215-221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Profiling of BoNT/C3-reversible gene expression induced by lysophosphatidic acid ephrinB1 gene up-regulation underlying neuropathic hyperalgesia and allodynia2009
- Author(s)
  Hitoshi Uchida
- Journal Title
  
  Neurochemistry International 54
  
  Pages : 215-221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Profiling of BoNT/C3-reversible gene expression induced by lysophosphatidic acid : ephrinB1 gene up-regulation underlying neuropathic hyperalgesia and allodynia2009
- Author(s)
  Hitoshi Uchida
- Journal Title
  
  Neurochemistry International 54
  
  Pages : 215-221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023022
[Journal Article] Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain.
- Author(s)
  Xie W, Uchida H, Nagai J, Ueda M, Chun J, Ueda H.
- Journal Title
  
  J Neurochem. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Presentation] 慢性疼痛とエピジェネティクス2015
- Author(s)
  内田仁司、植田弘師
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋市
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PROJECT-26830048
[Presentation] 神経障害性疼痛誘発因子リゾホスファチジン酸によるミエリン関連遺伝子の転写抑制機構2015
- Author(s)
  内田仁司、植田弘師
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋市
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PROJECT-26830048
[Presentation] 断続的冷温負荷による線維筋痛症モデルに対するドネペジルの疼痛改善作用2014
- Author(s)
  内田仁司、迎　武紘、植田弘師
- Organizer
  第67回日本薬理学会西南部会
- Place of Presentation
  産業医科大学（福岡県北九州市）
- Year and Date
  2014-11-23
- Data Source
  KAKENHI-PROJECT-26253077
[Presentation] 神経障害性疼痛原因分子LPAによる脱髄とアセチル化修飾2014
- Author(s)
  内田仁司、濱田将徳、植田弘師
- Organizer
  第36回日本疼痛学会
- Place of Presentation
  大阪市
- Year and Date
  2014-06-21
- Data Source
  KAKENHI-PROJECT-26830048
[Presentation] 断続的冷温負荷による線維筋痛症モデルに対するドネペジルの疼痛改善作用2014
- Author(s)
  内田仁司、迎武紘、植田弘師
- Organizer
  第67回日本薬理学会西南部会
- Place of Presentation
  北九州市
- Year and Date
  2014-11-23
- Data Source
  KAKENHI-PROJECT-26830048
[Presentation] 創薬に向けた線維筋痛症モデル動物の病態解析と治療戦略2014
- Author(s)
  内田仁司、植田弘師
- Organizer
  日本線維筋痛症学会第6回学術集会
- Place of Presentation
  長野市
- Year and Date
  2014-09-14
- Data Source
  KAKENHI-PROJECT-26830048
[Presentation] 神経細胞におけるRNA編集酵素遺伝子のエピゲノム制御2013
- Author(s)
  内田仁司, 伊藤誠二
- Organizer
  第15回日本RNA学会年会
- Place of Presentation
  愛媛県民文化会館・ひめぎんホール(愛媛県松山市)
- Year and Date
  2013-07-24
- Data Source
  KAKENHI-PROJECT-11J09224
[Presentation] Developmental regulation of RNA editing in mouse dorsal root ganglion2012
- Author(s)
  内田仁司
- Organizer
  Neuroscience 2012
- Year and Date
  2012-10-13
- Data Source
  KAKENHI-PROJECT-11J09224
[Presentation] Resistance to morphine anaigesia and its underlying mechanisms in an experimental mouse model of fibromyalgia2011
- Author(s)
  内田仁司
- Organizer
  1st Bio-Rheumatology International Congress/8th GARN meetins
- Place of Presentation
  千葉・ヒルトン東京ベイホテル
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-11J09224
[Presentation] 慢性疼痛におけるヒストン脱アセチル化酵素を標的とした新たな治療戦略2011
- Author(s)
  内田仁司
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-03-23
- Data Source
  KAKENHI-PROJECT-22600007
[Presentation] 慢性疼痛におけるエピジェネティクス:疼痛関連遺伝子群のサイレンシング制御機構の解明2010
- Author(s)
  内田仁司
- Organizer
  平成22年度生理学研究所研究会
- Place of Presentation
  名古屋
- Year and Date
  2010-12-03
- Data Source
  KAKENHI-PROJECT-22600007
[Presentation] 神経因性疼痛を担う疼痛関連遺伝子のエピジェネディクス異常2010
- Author(s)
  内田仁司
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20023022
[Presentation] 神経因性疼痛を担う疼痛関連遺伝子のエピジェネティクス異常2010
- Author(s)
  内田仁司
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-17109015
[Presentation] Epigenetic gene silencing via NRSF in chronic neuropathic pain2010
- Author(s)
  内田仁司
- Organizer
  Neuroscience 2010
- Place of Presentation
  サンディエゴ
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-22600007
[Presentation] 難治性神経因性疼痛における疼痛関連遺伝子群のサイレンシング制御機構2010
- Author(s)
  内田仁司
- Organizer
  Neuro2010
- Place of Presentation
  神戸
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-22600007
[Presentation] 慢性痛における神経可塑性を担うエピジェネティクス異常2009
- Author(s)
  内田仁司
- Organizer
  第26回日本薬学会九州支部総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20023022
[Presentation] 慢性痛における神経可塑性を担うエピジェネティクス異常2009
- Author(s)
  内田仁司
- Organizer
  第26回日本薬学会九州支部総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-17109015
[Presentation] Profiling of pain-related genes induced by lysophosphatidic acid, an initiator of neuropathic pain2009
- Author(s)
  内田仁司
- Organizer
  第82回日本薬理学会
- Place of Presentation
  横浜
- Year and Date
  2009-03-16
- Data Source
  KAKENHI-PROJECT-17109015
[Presentation] 慢性疼痛とエピジェネティクス
- Author(s)
  内田仁司、植田弘師
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-03-18 – 2015-03-20
- Invited
- Data Source
  KAKENHI-PROJECT-26253077
[Presentation] 神経障害性疼痛誘発因子リゾホスファチジン酸によるミエリン関連遺伝子の転写抑制機構
- Author(s)
  内田仁司、植田弘師
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26253077
[Presentation] 神経障害性疼痛原因分子LPAによる脱髄とアセチル化修飾
- Author(s)
  内田仁司、濱田将徳、植田弘師
- Organizer
  第36回　日本疼痛学会
- Place of Presentation
  KKR大阪（大阪府大阪市）
- Year and Date
  2014-06-20 – 2014-06-21
- Data Source
  KAKENHI-PROJECT-26253077
[Presentation] 創薬に向けた線維筋痛症モデル動物の病態解析と治療戦略
- Author(s)
  内田仁司、植田弘師
- Organizer
  日本線維筋痛症学会　第６回学術集会
- Place of Presentation
  JA長野県ビル（長野県長野市）
- Year and Date
  2014-09-12 – 2014-09-14
- Invited
- Data Source
  KAKENHI-PROJECT-26253077

1. UEDA Hiroshi (00145674)

# of Collaborated Projects : 3results

# of Collaborated Products : 16results
2. INOUE Makoto (60380987)

# of Collaborated Projects : 2results

# of Collaborated Products : 2results
3. FUJITA Ryousuke (70380855)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
4. SUMIKAWA Koji (60028660)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
5. 植田睦美 (30437834)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
6. 松永隼人 (20437833)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. 永井潤 (20608369)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
8. 水田賢志 (50717618)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. 田中義正 (90280700)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. 水谷龍明 (50701843)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. YAO Ikuko

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
12. SETOU Mitsutoshi

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
13. 伊藤誠二

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
14. 片野泰代

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

UCHIDA Hitoshi 内田 仁司

Research Projects

Research Products

Co-Researchers

Elucidation of role of RNA editing in neuropathic painPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Reproduction of chronic pain model through a reconstitution of neuronal circuit components including LPA priming and iPS cells, and its application for drug discovery

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Integrative understanding of epigenetic silencing in neuropathic painPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

難治性神経因性疼痛を担うエピジェネティクス異常とその調節機構の解明Research Fellow

Research Fellow

Project Period (FY)

Research Category

Research Field

Research Institution

脂質シグナリングによる痛みの記憶化:エピジェネティクス制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ストレス性精神疾患の可視化とナノメディシン

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of molecular targets to cure intractable neuropathic pain with nerve injury-induced demyelination

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Epigenetic modification in neuropathic pain2015

Author(s)

Journal Title

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[Journal Article] Donepezil reverses intermittent stress-induced generalized chronic pain syndrome in mice2015

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[Journal Article] Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury2015

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[Journal Article] Epigenetic Modification in Neuropathic Pain.2015

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[Journal Article] Identification of nitrated tyrosine residues of protein kinase G-Iα by mass spectrometry2014

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[Journal Article] Lysophosphatidic acid and its receptors LPA1 and LPA3 mediate paclitaxel-induced neuropathic pain in mice2014

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[Journal Article] 痛みによるepigenetic修飾2014

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[Journal Article] Epigenetic regulation of BDNF expression in the primary sensoryneurons after peripheral nerve injury: Implications in the development of neuropathic pain.2013

UCHIDA Hitoshi 内田仁司