Hara Masatoshi 原昌稔

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HARA Massatoshi 原昌稔

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Researcher Number	30565099
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院生命機能研究科, 招へい准教授 2025: 東京大学, 大学院理学系研究科(理学部), 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院生命機能研究科, 助教 2020 – 2021: 大阪大学, 生命機能研究科, 助教 2016 – 2017: 大阪大学, 生命機能研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 43050:Genome biology-related / Biological Sciences / Molecular biology
Keywords	Principal Investigator セントロメア / キネトコア / 染色体分配 / 翻訳調節 / 母性mRNA / ショウジョウバエ / 母性mRNA翻訳調節 / 卵賦活化 / 細胞周期 / エピゲノム … More / クロマチン構造 / CENP-C / クロマチン / 染色体 / M期キナーゼ / 分裂期 / CCAN Less

初期胚発生におけるセントロメア機能を維持する分子機構Principal Investigator
- Principal Investigator
  
  原昌稔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Osaka University
卵賦活化が引き起こす母性mRNA翻訳調節による全能性獲得機構の解明Principal Investigator
- Principal Investigator
  
  原昌稔
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Mechanisms establishing higher-order structure of centromeric chromatinPrincipal Investigator
- Principal Investigator
  
  Hara Masatoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Osaka University
Regulatory mechanisms of maternal mRNAs translation during egg activationPrincipal Investigator
- Principal Investigator
  
  原昌稔
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Regulatory mechanisms of cell cycle-dependent switching of protein interaction network in vertebrate kinetochorePrincipal Investigator
- Principal Investigator
  
  HARA Massatoshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2018 2017 2016

All Journal Article Presentation

[Journal Article] Centromere/kinetochore is assembled through CENP-C oligomerization2023
- Author(s)
  Hara Masatoshi、Ariyoshi Mariko、Sano Tomoki、Nozawa Ryu-Suke、Shinkai Soya、Onami Shuichi、Jansen Isabelle、Hirota Toru、Fukagawa Tatsuo
- Journal Title
  
  Molecular Cell
  
  Volume: 83 Issue: 13 Pages: 2188-2205.e13
- DOI
  10.1016/j.molcel.2023.05.023
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19465, KAKENHI-PROJECT-23K18113, KAKENHI-PROJECT-21K06048, KAKENHI-PUBLICLY-22H04692, KAKENHI-PUBLICLY-22H05608, KAKENHI-PUBLICLY-23H04282, KAKENHI-PUBLICLY-23H04297, KAKENHI-PROJECT-22H04996, KAKENHI-PROJECT-22H00408, KAKENHI-PROJECT-20H03190, KAKENHI-PROJECT-21H02461
[Journal Article] Mobility of kinetochore proteins measured by FRAP analysis in living cells2022
- Author(s)
  Watanabe Reito、Hirano Yasuhiro、Hara Masatoshi、Hiraoka Yasushi、Fukagawa Tatsuo
- Journal Title
  
  Chromosome Research
  
  Volume: 30 Issue: 1 Pages: 43-57
- DOI
  10.1007/s10577-021-09678-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05533, KAKENHI-PUBLICLY-20H05389, KAKENHI-PLANNED-20H05891, KAKENHI-PUBLICLY-21H05752, KAKENHI-PROJECT-20H00454, KAKENHI-PROJECT-21H02461, KAKENHI-PROJECT-20K21395, KAKENHI-PROJECT-17H06167, KAKENHI-PROJECT-19K06489
[Journal Article] Recruitment of two Ndc80 complexes via the CENP-T pathway is sufficient for kinetochore functions2022
- Author(s)
  Takenoshita Yusuke、Hara Masatoshi、Fukagawa Tatsuo
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 851-851
- DOI
  10.1038/s41467-022-28403-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-20H05389, KAKENHI-PUBLICLY-21H05752, KAKENHI-PROJECT-21H02461, KAKENHI-PROJECT-20K21395, KAKENHI-PROJECT-17H06167
[Journal Article] The GNU subunit of PNG kinase, the developmental regulator of mRNA translation, binds BIC-C to localize to RNP granules2021
- Author(s)
  Aviles-Pagan Emir E、Hara Masatoshi、Orr-Weaver Terry L
- Journal Title
  
  eLife
  
  Volume: 10
- DOI
  10.7554/elife.67294
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-20H05367
[Journal Article] Kinetochore assembly and disassembly during mitotic entry and exit2018
- Author(s)
  Hara Masatoshi、Fukagawa Tatsuo
- Journal Title
  
  Current Opinion in Cell Biology
  
  Volume: 52 Pages: 73-81
- DOI
  10.1016/j.ceb.2018.02.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18491, KAKENHI-PLANNED-15H05972, KAKENHI-PROJECT-17H06167
[Journal Article] Association of M18BP1/KNL2 with CENP-A Nucleosome Is Essential for Centromere Formation in Non-mammalian Vertebrates2017
- Author(s)
  Tetsuya Hori, Wei-Hao Shang, Masatoshi Hara, Mariko Ariyoshi, Yasuhiro Arimura, Risa Fujita, Hitoshi Kurumizaka, Tatsuo Fukagawa
- Journal Title
  
  Developmental Cell
  
  Volume: 42 Issue: 2 Pages: 181-189
- DOI
  10.1016/j.devcel.2017.06.019
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07501, KAKENHI-PROJECT-17K15043, KAKENHI-INTERNATIONAL-15K21761, KAKENHI-ORGANIZER-15H05970, KAKENHI-PLANNED-15H05972, KAKENHI-PUBLICLY-16H01304, KAKENHI-PLANNED-25116002, KAKENHI-PROJECT-17H06167, KAKENHI-PROJECT-16J10043, KAKENHI-PROJECT-16K18491, KAKENHI-PROJECT-16H06279
[Journal Article] Critical Foundation of the Kinetochore: The Constitutive Centromere-Associated Network (CCAN)2017
- Author(s)
  Hara Masatoshi、Fukagawa Tatsuo
- Journal Title
  
  Prog Mol Subcell Biol.
  
  Volume: 56 Pages: 29-57
- DOI
  10.1007/978-3-319-58592-5_2
- ISBN
  9783319585918, 9783319585925
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-15H05972, KAKENHI-PROJECT-17H06167, KAKENHI-PROJECT-16K18491
[Presentation] マウスを用いたCENP-C機能ドメイン解析2024
- Author(s)
  原　昌稔、孔　維霞、繆　嘉航、若林　雄一、橋本　昌和、佐々木　洋、藤森　俊彦、深川　竜郎
- Organizer
  第41 回染色体ワークショップ・第22 回核ダイナミクス研究会
- Data Source
  KAKENHI-PUBLICLY-22H04672
[Presentation] マウスを用いたCENP-C機能ドメイン解析2024
- Author(s)
  原　昌稔、孔　維霞、繆　嘉航、若林　雄一、橋本　昌和、佐々木　洋、藤森　俊彦、深川　竜郎
- Organizer
  第41 回染色体ワークショップ・第22 回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-21H02461
[Presentation] 分裂期キネトコア形成の分子機構2024
- Author(s)
  竹之下　憂祐、有吉　眞理子、原　昌稔、深川　竜郎
- Organizer
  第41 回染色体ワークショップ・第22 回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-21H02461
[Presentation] The CENP-C-KMN Interaction Functions as a Safeguard for Accurate Chromosome Segregation2023
- Author(s)
  Masatoshi Hara, Weixia Kong, Yuich Wakabayashi, Masakazu Hashimoto, Hiroshi Sasaki, Toshihiko Fujimori, Tatsuo Fukagawa
- Organizer
  Cell Bio2023 ASCB|EMBO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02461
[Presentation] ショウジョウバエ卵賦活化における母性mRNA翻訳調節2023
- Author(s)
  原　昌稔
- Organizer
  全能性プログラム：デコーディングからデザインへ Epigenome Dynamics and Regulation in Germ Cells 第5回公開シンポジウム
- Data Source
  KAKENHI-PUBLICLY-22H04672
[Presentation] マウス初期発生過程における染色体分配機構の変化2023
- Author(s)
  原　昌稔、橋本　昌和、中川　真美、佐々木　洋、藤森　俊彦、深川　竜郎
- Organizer
  新学術領域研究『全能性プログラム』若手勉強会
- Data Source
  KAKENHI-PUBLICLY-22H04672
[Presentation] The molecular mechanism of the CENP-T-Mis12C interaction2023
- Author(s)
  Yusuke Takenoshita, Mariko Ariyoshi, Masatoshi Hara, Reiko Nakagawa, and Tatsuo Fukagawa
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02461
[Presentation] The CENP-C-KMN Interaction Functions as a Safeguard for Accurate Chromosome Segregation2023
- Author(s)
  Masatoshi Hara, Weixia Kong, Yuich Wakabayashi, Masakazu Hashimoto, Hiroshi Sasaki, Toshihiko Fujimori, Tatsuo Fukagawa
- Organizer
  Cell Bio2023 ASCB|EMBO Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04672
[Presentation] マウス初期発生過程における染色体分配機構の変化2023
- Author(s)
  原　昌稔、橋本　昌和、中川　真美、佐々木　洋、藤森　俊彦、深川　竜郎
- Organizer
  新学術領域研究『全能性プログラム』若手勉強会
- Data Source
  KAKENHI-PROJECT-21H02461
[Presentation] 正確な染色体分配を支える分子基盤2023
- Author(s)
  原　昌稔
- Organizer
  第2回細胞分裂研究会
- Data Source
  KAKENHI-PROJECT-21H02461
[Presentation] The mammalian CENP-C N-terminus is required for CENP-C function and maintenance of genome stability2023
- Author(s)
  Weixia Kong, Masatoshi Hara, Yasuhiro Hirano, Yuichi Wakabayashi , Tatsuo Fukagawa
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02461
[Presentation] セントロメアタンパク質CENP-Cの多量体化によるセントロメアクロマチン構造制御2023
- Author(s)
  原　昌稔
- Organizer
  第16回日本エピジェネティクス研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02461
[Presentation] 卵賦活化シグナルによる母性mRNA翻訳調節機構の解析2023
- Author(s)
  原　昌稔
- Organizer
  第2回細胞分裂研究会
- Data Source
  KAKENHI-PUBLICLY-22H04672
[Presentation] The CRISPR screening identifies genes which are genetically related to CENP-C2023
- Author(s)
  Jiahang Miao, Masatoshi Hara, Heather R. Keys, Kuan-Chung Su, Iain M. Cheeseman, Tatsuo Fukagawa
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02461
[Presentation] CENP-Cの自己多量体化はセントロメアクロマチンおよびキネトコアの形成に必須である2022
- Author(s)
  原　昌稔、有吉　眞理子、佐野　智基、野澤　竜介、新海　創也、大浪　修一、Isabelle Jansen、広田　亨、深川　竜郎
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02461
[Presentation] The role of the N-terminal conserved region of human CENP-C during mitotic progression2022
- Author(s)
  Kong Weixia, Masatoshi Hara, Yasuhiro Hirano, Tatsuo Fukagawa
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02461
[Presentation] Cenp-cΔex2-4はDMBA/TPA多段階皮膚発がんモデルにおいて腫瘍形成を促進する2022
- Author(s)
  徳永夕莉香、奥村和弘、磯貝恵理子、原昌稔、深川竜郎、若林雄一
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02461
[Presentation] The CRISPR screening identifies genes which are genetically related to CENP-C2022
- Author(s)
  Miao Jiahang, Hara Masatoshi, Heather R. Keys, Su Kuan-Chung, Iain M. Cheeseman, Fukagawa Tatsuo
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02461
[Presentation] キネトコア構成タンパク質CENP-Cの機能ドメイン解析2022
- Author(s)
  原　昌稔
- Organizer
  第１回細胞分裂研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02461
[Presentation] CENP-T-Mis12C結合の分子基盤2022
- Author(s)
  竹之下憂祐、有吉眞理子、原昌稔、深川竜郎
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02461
[Presentation] Translational control by PNG kinase complex during oocyte-to-embryo transition2022
- Author(s)
  原　昌稔
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-22H04672
[Presentation] Translational control of maternal mRNA during the oocyte-to-embryo transition in Drosophila2022
- Author(s)
  原　昌稔
- Organizer
  The International Symposium “Totipotency and Germ Cell Development
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04672
[Presentation] Kinetochore dynamics in the early embryonic development2021
- Author(s)
  Masatoshi Hara, Masakazu Hashimoto, Mami Nakagawa, Hiroshi Sasaki, Toshihiko Fujimori, Tatsuo Fukagawa
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H02461
[Presentation] CENP-CのCupinドメインを介した多量体化はその機能に必須である2021
- Author(s)
  原昌稔、有吉眞里子、深川竜郎
- Organizer
  第39回染色体ワークショップ・第39回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-21H02461
[Presentation] Analysis of domains of CENP-C in kinetochore formation2017
- Author(s)
  Eri Kakizono, Masatoshi Hara, Tatsuo Fukagawa
- Organizer
  第40回日本分子生物学会年会, 神戸
- Data Source
  KAKENHI-PROJECT-16K18491
[Presentation] Dynamically switching protein interaction networks during M-phase progression in vertebrate kinetochores2017
- Author(s)
  Masatoshi Hara, Tetsuya Hori, Tatsuo Fukagawa
- Organizer
  ASCB | EMBO 2017 Meeting, Philadelphia, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18491
[Presentation] 細胞周期に依存したセントロメアタンパク質の配置変化の分子機構とその役割2017
- Author(s)
  渡邉励人、原昌稔、深川竜郎
- Organizer
  日本遺伝学会第89回大会, 岡山
- Data Source
  KAKENHI-PROJECT-16K18491
[Presentation] キネトコアタンパク質の結合ネットワークの再考2017
- Author(s)
  原　昌稔、堀　哲也、深川　竜郎
- Organizer
  第69回日本細胞生物学会大会, 仙台
- Invited
- Data Source
  KAKENHI-PROJECT-16K18491
[Presentation] キネトコアタンパク質ネットワークの制御2016
- Author(s)
  原　昌稔、堀　哲也、深川　竜郎
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜 (神奈川県　横浜市)
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K18491

1. HIRAOKA Yasushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. HORI Tetsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. SHINKAI Soya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 深川竜郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 野澤竜介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hara Masatoshi 原 昌稔

HARA Massatoshi 原 昌稔

Research Projects

Research Products

Co-Researchers

初期胚発生におけるセントロメア機能を維持する分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

卵賦活化が引き起こす母性mRNA翻訳調節による全能性獲得機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms establishing higher-order structure of centromeric chromatinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanisms of maternal mRNAs translation during egg activationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanisms of cell cycle-dependent switching of protein interaction network in vertebrate kinetochorePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Centromere/kinetochore is assembled through CENP-C oligomerization2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mobility of kinetochore proteins measured by FRAP analysis in living cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recruitment of two Ndc80 complexes via the CENP-T pathway is sufficient for kinetochore functions2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The GNU subunit of PNG kinase, the developmental regulator of mRNA translation, binds BIC-C to localize to RNP granules2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Kinetochore assembly and disassembly during mitotic entry and exit2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of M18BP1/KNL2 with CENP-A Nucleosome Is Essential for Centromere Formation in Non-mammalian Vertebrates2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Critical Foundation of the Kinetochore: The Constitutive Centromere-Associated Network (CCAN)2017

Author(s)

Journal Title

DOI

ISBN

Data Source

[Presentation] マウスを用いたCENP-C機能ドメイン解析2024

Author(s)

Organizer

Data Source

[Presentation] マウスを用いたCENP-C機能ドメイン解析2024

Author(s)

Organizer

Data Source

[Presentation] 分裂期キネトコア形成の分子機構2024

Hara Masatoshi 原昌稔

HARA Massatoshi 原昌稔