Kusama Kazuya 草間和哉

Researcher Number	30579149
Other IDs	https://orcid.org/0000-0002-9120-0475
Affiliation (Current)	2024: 東京薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 東京薬科大学, 薬学部, 講師 2021: 東京薬科大学, 東京薬科大学薬学部, 助教 2019 – 2021: 東京薬科大学, 薬学部, 助教 2019: 東京薬科大学, 東京薬科大学薬学部, 助教 2016 – 2019: 東京大学, 大学院農学生命科学研究科(農学部), 特任助教 2015: 東京大学, 農学生命科学研究科, 研究員
Review Section/Research Field	Principal Investigator Basic Section 42010:Animal production science-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Animal production science Except Principal Investigator Basic Section 42010:Animal production science-related / Basic Section 56040:Obstetrics and gynecology-related / Animal production science
Keywords	Principal Investigator トロホブラスト / 胎盤 / ウシ / 内在性レトロウイルス / 内在性レトロウイルス因子 / 着床 / 細胞融合 / エクソソーム / 妊娠高血圧症候群 / 内在性レトロウイルス因子 … More / エピジェネティクス / 妊娠免疫 / 免疫寛容 / IFNT … More Except Principal Investigator ウシ / 受胎 / TLR2 / 受精卵 / 精子 / 子宮 / 着床 / 子宮内環境 / 胎盤構成細胞 / 二核細胞 / ウシ内在性レトロウイルス / SNX5 / 内在性レトロウイルス / 胎盤形成 / セノリシス / 細胞老化 / 子宮内膜症 / 免疫寛容 / 免疫反応 / IFNT / オルガノイド / PBMC / 着床成立 / 生体外モデル樹立 / 妊娠補助剤開発 / 子宮オルガノイド / IL-10 / IL-6 / 末梢血単核球 / 子宮灌流液 / 生体外モデル / 再構築 / 構築 / 妊娠成立 / タンパク質発現 / 遺伝子発現 / 子宮内膜 / 反芻動物 / 受胎率向上 / トロホブラスト細胞 / 細胞融合 / 上皮間葉系転換 / 着床・胎盤形成 Less

Elucidation of the differentiation mechanism of bovine placental cells focusing on the intracellular energy metabolism systemPrincipal Investigator
- Principal Investigator
  
  草間和哉
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Characterization of the pathophysiology of hypertensive disorder of pregnancy with novel endogenous genome factorsPrincipal Investigator
- Principal Investigator
  
  草間和哉
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Tokyo University of Pharmacy and Life Science
Mechanism of amplifying the immune tolerance toward pregnancy in the cow by the innate immune receptor TLR2 in sperm and embryo
- Principal Investigator
  
  宮本明夫
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
Basic research for the development of therapeutic agents on endometriosis based upon senolytic regulation
- Principal Investigator
  
  田村和広
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Analysis of differentiation mechanism of bovine trophoblast cells into placental component cells.
- Principal Investigator
  
  櫻井敏博
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Ohu University
A mechasism for bovine maternal immune tolerance toward pregnancy via sensing sperm and embryo
- Principal Investigator
  
  宮本明夫
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
Investigation and application of bovine placental formation by intrauterine genome dynamicsPrincipal Investigator
- Principal Investigator
  
  草間和哉
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Intrauterine environment during implantation in bovine pregnancy.
- Principal Investigator
  
  Sakurai Toshihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Ohu University
Investigation of assembly mechanism of placenta by retroelementPrincipal Investigator
- Principal Investigator
  
  Kusama Kazuya
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
  The University of Tokyo
Establishment and re-establishment of uterine environment for pregnancy success
- Principal Investigator
  
  Imakawa Kazuhiko
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Animal production science
- Research Institution
  Tokai University
  The University of Tokyo
Maternal immune strategy to recognize conceptus in mammalsPrincipal Investigator
- Principal Investigator
  
  Kusama Kazuya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Animal production science
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] セノリティック制御にもとづく新規子宮内膜症治療薬は可能か？2023
- Author(s)
  田村和広、草間和哉
- Journal Title
  
  細胞
  
  Volume: 55 (2) Pages: 36-38
- Data Source
  KAKENHI-PROJECT-22K09651
[Journal Article] Expression of NFIL3 and CEBPA regulated by IFNT induced-PGE2 in bovine endometrial stromal cells during the pre-implantation period2023
- Author(s)
  Rulan Bai, Kazuya Kusama, Yuta Matsuno, Hanako Bai, Toshihiro Sakurai, Koji Kimura, Kazuhiko Imakawa
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 14 Pages: 1075030-1075030
- DOI
  10.3389/fendo.2023.1075030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03133, KAKENHI-PROJECT-23K23767
[Journal Article] Endoplasmic reticulum stress-regulated high temperature requirement A1 (HTRA1) modulates invasion and angiogenesis-related genes in human trophoblasts2022
- Author(s)
  Kanoko Yoshida, Kazuya Kusama, Mana Azumi, Mikihiro Yoshie, Kiyoko Kato,Kazuhiro Tamura
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 150 Issue: 4 Pages: 267-274
- DOI
  10.1016/j.jphs.2022.10.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03133
[Journal Article] Alpha 1 Antitrypsin Regulates Trophoblast Syncytialization and Inflammatory Factor Expression2022
- Author(s)
  Yoshida K, Yano A, Kusama K, Ishikawa G, Tamura K
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 4 Pages: 1955-1955
- DOI
  10.3390/ijms23041955
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03133
[Journal Article] Endogenous Retroviruses and Placental Evolution, Development, and Diversity2022
- Author(s)
  Imakawa Kazuhiko、Kusama Kazuya、Kaneko-Ishino Tomoko、Nakagawa So、Kitao Koichi、Miyazawa Takayuki、Ishino Fumitoshi
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 15 Pages: 2458-2458
- DOI
  10.3390/cells11152458
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20584, KAKENHI-PROJECT-19KK0182, KAKENHI-PROJECT-20H03133, KAKENHI-PROJECT-20J22607
[Journal Article] Characterization of Serum Metabolome and Proteome Profiles Identifies SNX5 Specific for Pregnancy Failure in Holstein Heifers2022
- Author(s)
  Kusama Kazuya、Bai Rulan、Matsuno Yuta、Ideta Atsushi、Sakurai Toshihiro、Nagaoka Kentaro、Hori Masatoshi、Imakawa Kazuhiko
- Journal Title
  
  Life
  
  Volume: 12 Issue: 2 Pages: 309-309
- DOI
  10.3390/life12020309
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14965, KAKENHI-PROJECT-19H03111, KAKENHI-PROJECT-20H03133, KAKENHI-PROJECT-19H03125, KAKENHI-PROJECT-23K23767
[Journal Article] Toll-like receptor signaling pathway triggered by inhibition of serpin A1 stimulates production of inflammatory cytokines by endometrial stromal cells2022
- Author(s)
  Kusama Kazuya、Satoyoshi Ayaka、Azumi Mana、Yoshie Mikihiro、Kojima Junya、Mizuno Yumi、Ono Masanori、Nishi Hirotaka、Kajihara Takeshi、Tamura Kazuhiro
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 13 Pages: 966455-966455
- DOI
  10.3389/fendo.2022.966455
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09650, KAKENHI-PROJECT-22K09651, KAKENHI-PROJECT-20H03133
[Journal Article] Intrauterine infusion of low levels of interferon‐tau on day‐8 post‐estrus stimulates the bovine endometrium to secrete apolipoprotein‐A1: A possible implication for early embryo tolerance2022
- Author(s)
  Rashid Mohammad B.、Marey Mohamed A.、Fukuda Kenji、Haneda Shingo、Kusama Kazuya、Shimada Masayuki、Imakawa Kazuhiko、Miyamoto Akio
- Journal Title
  
  American Journal of Reproductive Immunology
  
  Volume: 88 Issue: 3
- DOI
  10.1111/aji.13592
- Open Access
- Data Source
  KAKENHI-PROJECT-20H03122
[Journal Article] PGE2 and Thrombin Induce Myofibroblast Transdifferentiation via Activin A and CTGF in Endometrial Stromal Cells.2021
- Author(s)
  Kusama K, Fukushima Y, Yoshida K, Azumi M, Yoshie M, Mizuno Y, Kajihara T, Tamura K.
- Journal Title
  
  Endocrinology
  
  Volume: 162 Issue: 12
- DOI
  10.1210/endocr/bqab207
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09765, KAKENHI-PROJECT-20H03133, KAKENHI-PROJECT-20K09650
[Journal Article] Alpha-1 Antitrypsin-Induced Endoplasmic Reticulum Stress Promotes Invasion by Extravillous Trophoblasts2021
- Author(s)
  Yoshida Kanoko、Kusama Kazuya、Fukushima Yuta、Ohmaru-Nakanishi Takako、Kato Kiyoko、Tamura Kazuhiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 7 Pages: 3683-3683
- DOI
  10.3390/ijms22073683
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03800, KAKENHI-PROJECT-20H03133
[Journal Article] Heat stress induces oxidative stress and activates the KEAP1-NFE2L2-ARE pathway in bovine endometrial epithelial cells2021
- Author(s)
  Murata Hirona, Kunii Hiroki ,Kusama Kazuya, Sakurai Toshihiro, Bai Hanako、Kawahara Manabu、Takahashi Masashi
- Journal Title
  
  Biology of Reproduction
  
  Volume: 105 Issue: 5 Pages: 1114-1125
- DOI
  10.1093/biolre/ioab143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15644, KAKENHI-PROJECT-19H03111, KAKENHI-PROJECT-21H02336
[Journal Article] Neutrophils recognize and amplify IFNT signals derived from day 7 bovine embryo for stimulation of ISGs expression in vitro: A possible implication for the early maternal recognition of pregnancy.2021
- Author(s)
  Fiorenza MF, Marey MA, Rashid MB, Zinnah MA, Ma D, Morillo VA, Kusama K, Shimada M, Imakawa K, Antoniazzi AQ, Miyamoto A.
- Journal Title
  
  Biochem Biophy Res Comm
  
  Volume: 553 Pages: 37-43
- Open Access
- Data Source
  KAKENHI-PROJECT-20H03122
[Journal Article] Senolytic treatment modulates decidualization in human endometrial stromal cells2021
- Author(s)
  Kusama Kazuya、Yamauchi Naoya、Yoshida Kanoko、Azumi Mana、Yoshie Mikihiro、Tamura Kazuhiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 571 Pages: 174-180
- DOI
  10.1016/j.bbrc.2021.07.075
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09765, KAKENHI-PROJECT-20H03133
[Journal Article] Day 7 embryos change the proteomics and exosomal micro-RNAs content of bovine uterine fluid: Involvement of innate immune functions.2021
- Author(s)
  Kusama K, Rashid MB, Kowsar R, Marey MA, Talukder AK, Nagaoka K, Shimada M, Khatib H, Imakawa K, Miyamoto A.
- Journal Title
  
  Frontiers in Genetics
  
  Volume: 12 Pages: 676791-676791
- Open Access
- Data Source
  KAKENHI-PROJECT-20H03122
[Journal Article] The effect of bta-miR-26b in intrauterine extracellular vesicles on maternal immune system during the implantation period2021
- Author(s)
  Nakamura K, Kusama K, Hori M, Imakawa K
- Journal Title
  
  Biochemical and biophysical research communications
  
  Volume: 573 Pages: 100-106
- DOI
  10.1016/j.bbrc.2021.08.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03133
[Journal Article] 反芻動物の着床期における細胞外分泌小胞エクソソームの役割と展望2021
- Author(s)
  中村圭吾, 草間和哉, 須田義人, 堀正敏, 今川和彦
- Journal Title
  
  Nihon Chikusan Gakkaiho
  
  Volume: 92 Issue: 2 Pages: 131-139
- DOI
  10.2508/chikusan.92.131
- NAID
  130008063823
- ISSN
  1346-907X, 1880-8255
- Year and Date
  2021-05-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03133
[Journal Article] Day 7 Embryos Change the Proteomics and Exosomal Micro-RNAs Content of Bovine Uterine Fluid: Involvement of Innate Immune Functions2021
- Author(s)
  Kusama K, Rashid MB, Kowsar R, Marey MA, Talukder AK, Nagaoka K, Shimada M, Khatib H, Imakawa K, Miyamoto A
- Journal Title
  
  Frontiers in genetics
  
  Volume: 12 Pages: 676791-676791
- DOI
  10.3389/fgene.2021.676791
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03133
[Journal Article] Endometrial epithelial?mesenchymal transition (EMT) by menstruation-related inflammatory factors during hypoxia2021
- Author(s)
  Kusama K、Fukushima Y、Yoshida K、Sakakibara H、Tsubata N、Yoshie M、Kojima J、Nishi H、Tamura K
- Journal Title
  
  Molecular Human Reproduction
  
  Volume: 27 Issue: 6
- DOI
  10.1093/molehr/gaab036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16816, KAKENHI-PROJECT-20H03133
[Journal Article] Roadmap to pregnancy in the first 7 days post-insemination in the cow: Immune crosstalk in the corpus luteum, oviduct, and uterus2020
- Author(s)
  Talukder AK, Marey MA, Shirasuna K, Kusama K, Shimada M, Imakawa K, Miyamoto A.
- Journal Title
  
  Theriogenology
  
  Volume: 148 Pages: 313-320
- DOI
  10.1016/j.theriogenology.2020.01.071
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05013, KAKENHI-PROJECT-17F17407, KAKENHI-PROJECT-18K19259, KAKENHI-PROJECT-16H02584
[Journal Article] Emerging Role of Extracellular Vesicles in Embryo-Maternal Communication throughout Implantation Processes2020
- Author(s)
  Nakamura K, Kusama K, Suda Y, Fujiwara H, Hori M, Imakawa K
- Journal Title
  
  International journal of molecular sciences
  
  Volume: 21 Issue: 15 Pages: 5523-5523
- DOI
  10.3390/ijms21155523
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03133
[Journal Article] IFNT-independent effects of intrauterine extracellular vesicles (EVs) in cattle2020
- Author(s)
  Nakamura Keigo、Kusama Kazuya、Ideta Atsushi、Imakawa Kazuhiko、Hori Masatoshi
- Journal Title
  
  Reproduction
  
  Volume: 159 Issue: 5 Pages: 503-511
- DOI
  10.1530/rep-19-0314
- NAID
  130007925663
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14566, KAKENHI-PROJECT-16H02584
[Journal Article] Effects of miR-98 in intrauterine extracellular vesicles on maternal immune regulation during the peri-implantation period in cattle2019
- Author(s)
  Nakamura Keigo、Kusama Kazuya、Ideta Atsushi、Kimura Koji、Hori Masatoshi、Imakawa Kazuhiko
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 20330-20330
- DOI
  10.1038/s41598-019-56879-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14566, KAKENHI-PROJECT-16H02584
[Journal Article] Regulation of human trophoblast cell syncytialization by transcription factors STAT5B and NR4A3.2018
- Author(s)
  Kusama その他
- Journal Title
  
  J Cell Biochem
  
  Volume: - Issue: 6 Pages: 4918-4927
- DOI
  10.1002/jcb.26721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02584
[Journal Article] Integration of molecules to construct the processes of conceptus implantation to the maternal endometrium2018
- Author(s)
  Imakawa K、Bai R、Kusama K
- Journal Title
  
  J Anim Sci
  
  Volume: 未定 Issue: 7 Pages: 3009-3021
- DOI
  10.1093/jas/sky103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18767, KAKENHI-PROJECT-16H02584
[Journal Article] Evidence that interferon-tau secreted from Day-7 embryo in vivo generates anti-inflammatory immune response in the bovine uterus2018
- Author(s)
  Rashid MB, Talukder AK, Kusama K, Haneda S, Takedomi T, Yoshino H, Moriyasu S, Matsui M, Shimada M, Imakawa K, Miyamoto A.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 500 Issue: 4 Pages: 879-884
- DOI
  10.1016/j.bbrc.2018.04.178
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02584, KAKENHI-PROJECT-16H05013, KAKENHI-PROJECT-17K19324
[Journal Article] Intrauterine exosomes are required for bovine conceptus implantation.2018
- Author(s)
  Kusama その他
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 495 Issue: 1 Pages: 1370-1375
- DOI
  10.1016/j.bbrc.2017.11.176
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02584, KAKENHI-PROJECT-15K07697, KAKENHI-PROJECT-15K18767
[Journal Article] Induction of immune-related gene expression by seminal exosomes in the porcine endometrium2018
- Author(s)
  Bai Rulan、Latifi Zeinab、Kusama Kazuya、Nakamura Keigo、Shimada Masayuki、Imakawa Kazuhiko
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 495 Issue: 1 Pages: 1094-1101
- DOI
  10.1016/j.bbrc.2017.11.100
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18767, KAKENHI-PROJECT-16H02584
[Journal Article] Down-regulation of transcription factor OVOL2 contributes to epithelial-mesenchymal transition in a noninvasive type of trophoblast implantation to the maternal endometrium.2018
- Author(s)
  Bai その他
- Journal Title
  
  FASEB J
  
  Volume: - Issue: 6 Pages: 3371-3384
- DOI
  10.1096/fj.201701131rr
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02584, KAKENHI-PROJECT-16F16403, KAKENHI-PROJECT-15K07697, KAKENHI-PROJECT-15K18767
[Journal Article] Oviduct epithelium induces interferon-tau in bovine Day-4 embryos, which generates an anti-inflammatory response in immune cells.2018
- Author(s)
  Talukder AK, Rashid MB, Yousef MS, Kusama K, Shimizu T, Shimada M, Suarez SS, Imakawa K, Miyamoto A.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 7580-7580
- DOI
  10.1038/s41598-018-26224-8
- NAID
  120006694201
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02584, KAKENHI-PROJECT-16H05013, KAKENHI-PROJECT-17K19324
[Journal Article] Thirty years of interferon-tau research; Past, present and future perspective.2017
- Author(s)
  Imakawa その他
- Journal Title
  
  Anim Sci J
  
  Volume: 88 Issue: 7 Pages: 927-936
- DOI
  10.1111/asj.12807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02584, KAKENHI-PROJECT-15K18767
[Journal Article] Continuous model of conceptus implantation to the maternal endometrium.2017
- Author(s)
  Imakawa K, Bai R, Fujiwara H, Ideta A, Aoyagi Y, Kusama K.
- Journal Title
  
  Journal of Endocrinology
  
  Volume: 233 Issue: 1 Pages: R53-R65
- DOI
  10.1530/joe-16-0490
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18767, KAKENHI-PROJECT-16H02584, KAKENHI-PROJECT-16F16403
[Journal Article] Increase in complement iC3b is associated with anti-inflammatory cytokine expression during late pregnancy in mice.2017
- Author(s)
  Nakamura その他
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 5 Pages: e0178442-e0178442
- DOI
  10.1371/journal.pone.0178442
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02584, KAKENHI-PROJECT-15K18767
[Journal Article] A transcriptional cofactor YAP regulates IFNT expression via transcription factor TEAD in bovine conceptuses.2016
- Author(s)
  Kusama K., Bai R., Sakurai T., Bai H., Ideta A., Aoyagi Y., Imakawa K.
- Journal Title
  
  Domestic Animal Endocrinology
  
  Volume: 57 Pages: 21-30
- DOI
  10.1016/j.domaniend.2016.05.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07697, KAKENHI-PROJECT-15K18767, KAKENHI-PROJECT-16H02584
[Journal Article] Endometrial factors similarly induced by IFNT2 and IFNTc1 through transcription factor FOXS1.2016
- Author(s)
  Kusama K, Bai R, Nakamura K, Okada S, Yasuda J, Imakawa K
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 2 Pages: e0171858-e0171858
- DOI
  10.1371/journal.pone.0171858
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18767, KAKENHI-PROJECT-16H02584
[Journal Article] Conceptus implantation and placentation: molecules related to epithelial–mesenchymal transition, lymphocyte homing, endogenous retroviruses, and exosomes2016
- Author(s)
  Imakawa K, Bai R, Fujiwara H, Kusama K
- Journal Title
  
  Reproductive Medicine and Biology
  
  Volume: 15 Issue: 1 Pages: 1-11
- DOI
  10.1007/s12522-015-0215-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18767, KAKENHI-PROJECT-25660209
[Journal Article] Regulation of epithelial to mesenchymal transition in bovine conceptuses through the interaction between follistatin and activin A2016
- Author(s)
  Kazuya Kusama, Rulan Bai, Atsushi Ideta, Yoshito Aoyagi, Kiyoshi Okuda, Kazuhiko Imakawa
- Journal Title
  
  Molecular and Cellular Endocrinology
  
  Volume: 434 Pages: 81-92
- DOI
  10.1016/j.mce.2016.06.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26292136, KAKENHI-PROJECT-15K18767, KAKENHI-PROJECT-16H02584
[Presentation] 子宮内膜間質細胞のSERPINA1発現低下はTLR3/4を介して炎症を増強する」2022
- Author(s)
  草間和哉
- Organizer
  第27回日本生殖内分泌学会学術集会 2022年12月17日-18日
- Data Source
  KAKENHI-PROJECT-22K09651
[Presentation] Roadmap to pregnancy in the first 7 days post-insemination in the cow: Immune cross-talk in the corpus luteum, oviduct and uterus.2022
- Author(s)
  2)Miyamoto A, Talukder AK, Marey MA, Shirasuna K, Kusama K, Shimada M, Imakawa K.
- Organizer
  19th International Congress on Animal Reproduction (ICAR)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03122
[Presentation] Intracellular serpin A1 regulates inflammatory cytokines expression via toll-like receptor signaling pathway in endometrial stromal cells2022
- Author(s)
  草間和哉
- Organizer
  第96回日本薬理学会年会 2022年11月30日-12月3日
- Data Source
  KAKENHI-PROJECT-22K09651
[Presentation] ウシ胎盤細胞融合における内在性レトロウイルス遺伝子の発現調節機構の解明2019
- Author(s)
  草間和哉，田村和広，堀正敏，今川和彦
- Organizer
  第112回日本繁殖生物学会
- Data Source
  KAKENHI-PROJECT-18K14566
[Presentation] 子宮内エクソソーム miR-98 による胚接着時の母体免疫系の抑制2019
- Author(s)
  中村圭吾，草間和哉，出田篤司，今川和彦，堀正敏
- Organizer
  第112回日本繁殖生物学会
- Data Source
  KAKENHI-PROJECT-18K14566
[Presentation] Bovine endogenous retroviral genes necessary for the trophoblast fusion are up-regulated by PPARG and cAMP after conceptus implantation2018
- Author(s)
  Kazuya Kusama
- Organizer
  Society for the Study of Reproduction
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02584
[Presentation] Bovine endogenous retroviral genes necessary for the trophoblast fusion are up-regulated by PPARG and cAMP after conceptus implantation2018
- Author(s)
  Kazuya Kusama, Rulan Bai, Masako Suzuki, John Greally, Kazuhiko Imakawa
- Organizer
  Society for the study of Reproduction (SSR) 51st Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14566
[Presentation] PPARG and cAMP regulate bovine endogenous retroviral gene expression necessary for the formation of multinucleate trophectodermal cells2017
- Author(s)
  Kazuya Kusama, Rulan Bai, Jan-Dirk Haeger, Christiane Pfarrer, Kazuhiko Imakawa
- Organizer
  The Society for the Study of Reproduction
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18767
[Presentation] ヒト栄養膜細胞のcAMP誘導性細胞融合におけるOVOL1/2発現制御2016
- Author(s)
  草間和哉、白汝嵐、今川和彦
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K18767
[Presentation] ウシ胚ー子宮間における上皮間葉系転換(EMT)の時間特異的制御2015
- Author(s)
  草間和哉、白汝嵐、中村圭吾、安田二朗、今川和彦
- Organizer
  第108回日本繁殖生物学会大会
- Place of Presentation
  宮崎大学（宮崎県・宮崎市）
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-15K18767

1. IMAKAWA Kazuhiko (00291956)

# of Collaborated Projects: 4 results

# of Collaborated Products: 16 results
2. Sakurai Toshihiro (70568253)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. 島田昌之 (20314742)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. 唄花子 (60775443)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 宮本明夫 (10192767)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. 堀正敏 (70211547)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. 中尾洋一 (60282696)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 李俊佑 (10313082)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 永岡謙太郎 (60376564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 田村和広 (70281409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 小島淳哉 (70617539)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. YOSHIE Mikihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. KAJIHARA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. MIZUNO Yosuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. MIZUNO Yumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 加藤聖子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 石野史敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 石野知子(金児知子)

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 佐藤毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 奥田潔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kusama Kazuya 草間 和哉

Research Projects

Research Products

Co-Researchers

Elucidation of the differentiation mechanism of bovine placental cells focusing on the intracellular energy metabolism systemPrincipal Investigator

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Characterization of the pathophysiology of hypertensive disorder of pregnancy with novel endogenous genome factorsPrincipal Investigator

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Mechanism of amplifying the immune tolerance toward pregnancy in the cow by the innate immune receptor TLR2 in sperm and embryo

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Basic research for the development of therapeutic agents on endometriosis based upon senolytic regulation

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Analysis of differentiation mechanism of bovine trophoblast cells into placental component cells.

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A mechasism for bovine maternal immune tolerance toward pregnancy via sensing sperm and embryo

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Investigation and application of bovine placental formation by intrauterine genome dynamicsPrincipal Investigator

Principal Investigator

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Intrauterine environment during implantation in bovine pregnancy.

Principal Investigator

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Investigation of assembly mechanism of placenta by retroelementPrincipal Investigator

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Establishment and re-establishment of uterine environment for pregnancy success

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Maternal immune strategy to recognize conceptus in mammalsPrincipal Investigator

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[Journal Article] セノリティック制御にもとづく新規子宮内膜症治療薬は可能か？2023

Author(s)

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[Journal Article] Expression of NFIL3 and CEBPA regulated by IFNT induced-PGE2 in bovine endometrial stromal cells during the pre-implantation period2023

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[Journal Article] Endoplasmic reticulum stress-regulated high temperature requirement A1 (HTRA1) modulates invasion and angiogenesis-related genes in human trophoblasts2022

Kusama Kazuya 草間和哉