Inoue Shigeaki 井上茂亮

… Alternative Names

Researcher Number	30582209
Other IDs
Affiliation (Current)	2021: 神戸大学, 医学研究科, 特命教授
Affiliation (based on the past Project Information) *help	2018 – 2020: 神戸大学, 医学研究科, 特命教授 2014 – 2019: 東海大学, 医学部, 准教授 2011 – 2013: 東海大学, 創造科学技術研究機構, 講師
Review Section/Research Field	Principal Investigator Emergency medicine / Basic Section 55060:Emergency medicine-related Except Principal Investigator Basic Section 55050:Anesthesiology-related / Basic Section 55020:Digestive surgery-related / Anesthesiology / Tumor diagnostics
Keywords	Principal Investigator 敗血症 / 免疫 / IL-15 / 老化 / 高齢者 / T細胞 / 免疫抑制 / SOCS1 / In silico screening / 免疫疲弊 … More Except Principal Investigator 感染症 / 敗血症 / マクロファージ / 抗原提示 / 自己免疫疾患 / ハイスループットスクリーニング / 炎症 / 高齢化 / がん / 免疫療法 / 酵素阻害 / マクロファージ活性化因子 / αガラクトサミニザーゼ / 酵素阻害剤 / αガラクトサミニダーゼ / 肺癌手術 / 麻酔薬 / 免疫抑制 / プロポフォール / セボフルラン / デスフルラン / 免疫老化 / 肺がん / 手術 / 白血球 / サイトカイン / 予後 / モノクローナル抗体 / 多剤耐性菌 / MRSA / 感染菌 / 抗体 / 高齢者 / インターロイキン１５ / 免疫賦活 / 抗腫瘍免疫応答 / 胃癌 / CD8 T細胞 / NKT細胞 / インフルエンザワクチン / レジデントメモリーT細胞 / 腫瘍浸潤リンパ球 / 大腸癌 / 肺転移 / 組織滞在型メモリーT細胞 / 腫瘍浸潤T細胞 Less

A therapeutic strategy of post-intensive care syndrome focused on its mechanism and inflammation regulation in brain.Principal InvestigatorOngoing
- Principal Investigator
  
  井上茂亮
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kobe University
Mechanism elucidation of immunostimulatory action by interleukin-15 in the elderly with cancer-bearing conditionOngoing
- Principal Investigator
  
  鈴木知志
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kobe University
A novel cancer immunotherapy focused on organ specific immune memory generationOngoing
- Principal Investigator
  
  山下公大
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kobe University
肺がん患者における術中麻酔薬による免疫抑制メカニズムの機序解明と予後への影響Ongoing
- Principal Investigator
  
  川越いづみ
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Juntendo University
Establishment of antibody-cocktail therapy against invading bacteria for sepsis patientsOngoing
- Principal Investigator
  
  渡邊伸央
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Tokai University
A novel therapeutic strategy of sepsis in the elderly focusing on senescence of hematopoietic stem cell.Principal Investigator
- Principal Investigator
  
  井上茂亮
- Project Period (FY)
  2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Tokai University
Clarification of the mechanism of functional impairment of macrophages in sepsis and development of novel therapeutics
- Principal Investigator
  
  WATANABE Nobuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Tokai University
In silico screening of Interleukin-15 mimetics and application for a treatment of elderly septic patientsPrincipal Investigator
- Principal Investigator
  
  INOUE Shigeaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Tokai University
Research directed toward developing immune-recovery treatment based on inhibiting a glycosidease
- Principal Investigator
  
  Kanie Osamu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor diagnostics
- Research Institution
  Tokai University
A novel therapeutic strategy for sepsis with re-activating T cells in the elderlyPrincipal Investigator
- Principal Investigator
  
  INOUE Shigeaki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Tokai University
Immunoanalysis of severe septic patients in the elderly and therapeutic potential of IL-15Principal Investigator
- Principal Investigator
  
  INOUE Shigeaki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Tokai University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Usefulness of next-generation DNA sequencing for the diagnosis of urinary tract infection2020
- Author(s)
  Ishihara T, Watanabe N, Inoue S, Aoki H, Tsuji T, Yamamoto B, Yanagi H, Oki M1, Kryukov K, Nakagawa S, Inokuchi S, Ozawa H, Imanishi T
- Journal Title
  
  DD&T
  
  Volume: 14
- DOI
  10.5582/ddt.2020.01000
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08868
[Journal Article] Papaverine identified as an inhibitor of high mobility group box 1/receptor for advanced glycation end-products interaction suppresses high mobility group box 1-mediated inflammatory responses2019
- Author(s)
  Tamada K, Nakajima S, Ogawa N, Inada M, Shibasaki H, Sato A, Takasawa R, Yoshimori A, Suzuki Y, Watanabe N, Oyama T, Abe H, Inoue S, Abe T, Yokomizo T, Tanuma S.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 511 Pages: 665-670
- DOI
  10.1016/j.bbrc.2019.01.136
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08868, KAKENHI-PROJECT-18H02685, KAKENHI-PROJECT-16K08327, KAKENHI-PROJECT-19K05737, KAKENHI-PROJECT-19KK0199, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05904, KAKENHI-PROJECT-18H02627
[Journal Article] A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction2019
- Author(s)
  Watanabe N, Kidokoro M, Suzuki Y, Tanaka M, Inoue S, Tsukamoto H, Hirayama N, Hsieh PW, Tseng CP, Nakagawa Y, Inokuchi S
- Journal Title
  
  PLOS ONE
  
  Volume: 14
- DOI
  10.1371/journal.pone.0222331
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08868
[Journal Article] Detection of pathogenic bacteria in the blood from sepsis patients using 16S rRNA gene amplicon sequencing analysis2018
- Author(s)
  Watanabe N, Kryukov K, Nakagawa S, Takeuchi JS, Takeshita M, Kirimura Y, Mitsuhashi S, Ishihara T, Aoki H, Inokuchi S, Imanishi T, Inoue S
- Journal Title
  
  PLOS ONE
  
  Volume: 13
- DOI
  10.1371/journal.pone.0202049
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08868, KAKENHI-PROJECT-17H07123, KAKENHI-PROJECT-16J40232
[Journal Article] Cha-Koji, comprising green tea leaves fermented with Aspergillus luchuensis var kawachii kitahara, increases regulatory T cell production in mice and humans2018
- Author(s)
  Yamamoto Bunsei、Suzuki Yusuke、Yonezu Takahisa、Mizushima Nanami、Watanabe Nobuo、Sato Takehito、Inoue Shigeaki、Inokuchi Sadaki
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 1 Pages: 1-8
- DOI
  10.1080/09168451.2018.1443789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10523
[Journal Article] A cell-based high-throughput screening assay system for inhibitor compounds of antigen presentation by HLA class II molecule2017
- Author(s)
  Watanabe Nobuo、Suzuki Yusuke、Yonezu Takahisa、Nakagawa Yuki、Shiina Takashi、Hirayama Noriaki、Inokuchi Sadaki、Inoue Shigeaki
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 1-12
- DOI
  10.1038/s41598-017-07080-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06502, KAKENHI-PROJECT-15K10523
[Journal Article] Nitrite administration improves sepsis-induced myocardial and mitochondrial dysfunction by modulating stress signal responses2017
- Author(s)
  Kawaguchi Ryoichi、Hirata Naoyuki、Tokinaga Yasuyuki、Hayashi Shunsuke、Inoue Shigeaki、Watanabe Nobuo、Yamakage Michiaki
- Journal Title
  
  Journal of Anesthesia
  
  Volume: 31 Pages: 885-894
- DOI
  10.1007/s00540-017-2417-0
- NAID
  40021413831
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10523, KAKENHI-PROJECT-26462367
[Journal Article] Sepsis induces incomplete M2 phenotype polarization in peritoneal exudate cells in mice2016
- Author(s)
  Watanabe N, Suzuki Y, Inokuchi S, Inoue S
- Journal Title
  
  J Intensive Care
  
  Volume: 4
- DOI
  10.1186/s40560-015-0124-1
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10523
[Journal Article] Persistent inflammation and T cell exhaustion in severe sepsis in the elderly.2014
- Author(s)
  Inoue S, Suzuki K, Komori Y et al:
- Journal Title
  
  Crit Care
  
  Volume: 18
- DOI
  10.1186/cc13941
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25861735
[Journal Article] Reduction of immunocompetent T cells followed by prolonged lymphopenia in severe sepsis in the elderly2013
- Author(s)
  Inoue S, Suzuki-Utsunomiya K, Okada Y, Iida Y, Taira T, Miura N, Tsuji T, Yamagiwa T, Morita S, Chiba T, Sato T, Inokuchi S
- Journal Title
  
  Crit Care Med
  
  Volume: 41 Pages: 810-819
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23792088
[Journal Article] Reduction of immunocompetent T cells followed by prolonged lymphopenia in severe sepsis in the eldery2013
- Author(s)
  Inoue, S.
- Journal Title
  
  Critical Care Medicine
  
  Volume: 41 Pages: 810-819
- DOI
  10.1097/ccm.0b013e318274645f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23792088, KAKENHI-PROJECT-25861735, KAKENHI-PUBLICLY-23118529
[Presentation] 肺癌手術において麻酔薬が術後の免疫抑制に及ぼす影響　-単施設前向き観察研究-2019
- Author(s)
  山口愛　川越いづみ　井上茂亮　河内山宰　福田征孝　稲田英一
- Organizer
  第67回日本麻酔科学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08865
[Presentation] 高齢者敗血症では疲弊したT細胞とICUでの２次感染が増加する。2015
- Author(s)
  井上　茂亮
- Organizer
  第42回日本集中治療医学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-02-10
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] 新たな免疫強化療法としての抗Programed death-1抗体の可能性～高齢者敗血症の治療法を探る2014
- Author(s)
  井上　茂亮
- Organizer
  日本老年医学会
- Place of Presentation
  福岡県福岡市
- Year and Date
  2014-06-13
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] Persistent inflammation and t cell exhaustion in severe sepsis in the elderly2014
- Author(s)
  Shigeaki Inoue
- Organizer
  米国ショック学会
- Place of Presentation
  米国　シャーロット
- Year and Date
  2014-06-09
- Invited
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] インターロイキン15は、インターフェロンγの産生とSTAT5のリン酸化を促進することで、加齢に伴うT細胞活性化障害を改善する2014
- Author(s)
  井上　茂亮
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島　鹿児島大学
- Invited
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] 高齢者敗血症患者における炎症と免疫抑制の病態生理2014
- Author(s)
  井上　茂亮
- Organizer
  第42日本救急医学会総会・学術集会
- Place of Presentation
  福岡県福岡市
- Year and Date
  2014-10-29
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] 免疫老化と高齢者敗血症 -病態と治療への免疫学的アプローチ2014
- Author(s)
  井上　茂亮
- Organizer
  第66回日本皮膚科学会西部支部学術大会
- Place of Presentation
  香川県高松市
- Year and Date
  2014-11-09
- Invited
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] Prolonged hypothermia and hypercytokinemia with apoptosis of lymphocytes in aged septic mice2013
- Author(s)
  Shigeaki Inoue
- Organizer
  Society of Critical Care Medicine’s 42nd Critical Care Congress
- Place of Presentation
  米国　プエルトリコ　サンファン
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] Interleukin 15 reverses age-related impairment T cell inactivation and proliferation with increasing pSTAT5 in elderly septic patients2013
- Author(s)
  Shigeaki Inoue
- Organizer
  15th Congress of the European Shock Society
- Place of Presentation
  オーストリア　ウィーン・Medical University of Vienna
- Invited
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] Interleukin 15 reverses age-related CD8+ T cell inactivation with increasing interferon-gamma production and improves survival in aged septic mice2013
- Author(s)
  Shigeaki Inoue
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  イタリア　ミラノ
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] Interleukin 15 reverses age-related T cell inactivation with increasing interferon-gamma and pSTAT3/5 production, and promotes T cell proliferation from septic patients in the elderly2013
- Author(s)
  Shigeaki Inoue
- Organizer
  15th Congress of the European Shock Society
- Place of Presentation
  オーストリア　ウィーン
- Invited
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] 敗血症における加齢の影響2013
- Author(s)
  井上　茂亮
- Organizer
  第28回日本Shock学会総会
- Place of Presentation
  東京　北里大学薬学部
- Invited
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] Prolonged elevation of serum Interleukin 6 and impairment of Tcell activation in elderly Patients with sepsis2013
- Author(s)
  Shigeaki Inoue
- Organizer
  第7回ｱｼﾞｱ救急医学会（ACEM2013)
- Place of Presentation
  東京東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] 本邦のショック領域からのクリニカルトライアルを目指して2013
- Author(s)
  井上　茂亮
- Organizer
  第28回日本Shock学会総会
- Place of Presentation
  東京都港区
- Invited
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] Reduction of immunocompetent T cells followed by prolonged lymphopenia in severe sepsis in the elderly2013
- Author(s)
  Shigeaki Inoue
- Organizer
  36th Annual Conference on Shock
- Place of Presentation
  アメリカ　サンディエゴ　Sheraton San Diego Hotel & Marina
- Invited
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] Reduction of immunocompetent T cells followed by prolonged lymphopenia in severe sepsis in the elderly2013
- Author(s)
  Shigeaki Inoue
- Organizer
  36th Annual Conference on Shock
- Place of Presentation
  米国　サンディエゴ
- Invited
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] Interleukin 15 reverses age-related CD8+ T cell inactivation with increasing interferon-gamma production and improves survival in aged septic mice2013
- Author(s)
  Shigeaki Inoue
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  イタリア　ミラノ　Mico-Milano Congressi
- Invited
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] 高齢者敗血症における免疫機能解析2012
- Author(s)
  井上　茂亮
- Organizer
  第27回日本Shock学会総会
- Place of Presentation
  東京都千代田区
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] 高齢者敗血症における末梢血単核球の免疫機能解析2012
- Author(s)
  井上茂亮鈴木恭子小森由香子井口貞樹
- Organizer
  第39回日本集中治療医学会学術集会
- Place of Presentation
  千葉幕張メッセ
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] 高齢マウス敗血症モデルにおける免疫抑制のメカニズムを探る。2012
- Author(s)
  井上　茂亮
- Organizer
  第27回日本Shock学会総会
- Place of Presentation
  東京都千代田区
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] IL-15は免疫応答細胞のアポトーシスを抑制し、高齢マウス敗血症の生命予後を改善する2012
- Author(s)
  井上　茂亮
- Organizer
  第19回外科侵襲とサイトカイン研究会
- Place of Presentation
  兵庫県神戸市
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation]2012
- Author(s)
  Inoue S, Suzuki-Utsumoniya K, Komori Y, Sato T, Inokuchi S
- Organizer
  日本外科代謝栄養学会第49回学術集会日韓合同シンポジウム講演
- Place of Presentation
  千葉
- Year and Date
  2012-07-06
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] Reduction and functional impairment of T cells in severe sepsis in the elderly2012
- Author(s)
  Shigeaki Inoue
- Organizer
  第49回日本外科代謝栄養学学術集会
- Place of Presentation
  千葉県浦安市
- Invited
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] Increased apoptosis of lymphocytes and prolonged cytokinemia in aged mice with sepsis2012
- Author(s)
  Shigeaki Inoue
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  兵庫県神戸市
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] Klothoマウス敗血症モデルにおける免疫機能解析2011
- Author(s)
  井上　茂亮
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  千葉県千葉市幕張メッセ
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] 高齢者敗血症における末梢血単核球の免疫機能解析2011
- Author(s)
  井上　茂亮
- Organizer
  第39回日本集中治療医学会学術集会
- Place of Presentation
  千葉県千葉市幕張メッセ
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] 免疫老化が敗血症に与える影響
- Author(s)
  井上　茂亮
- Organizer
  第２９回日本ショック学会
- Place of Presentation
  愛媛県松山市
- Year and Date
  2014-05-16 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-25861735

1. 山下公大 (80535427)

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22. SATO Akira

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# of Collaborated Products: 1 results
23. クリュコフキリル

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 椎名隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 平田直之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 田沼靖一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 高澤涼子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 横溝岳彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 佐藤健人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Inoue Shigeaki 井上 茂亮

INOUE Shigeaki 井上 茂亮

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A therapeutic strategy of post-intensive care syndrome focused on its mechanism and inflammation regulation in brain.Principal InvestigatorOngoing

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Mechanism elucidation of immunostimulatory action by interleukin-15 in the elderly with cancer-bearing conditionOngoing

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A novel cancer immunotherapy focused on organ specific immune memory generationOngoing

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肺がん患者における術中麻酔薬による免疫抑制メカニズムの機序解明と予後への影響Ongoing

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Establishment of antibody-cocktail therapy against invading bacteria for sepsis patientsOngoing

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A novel therapeutic strategy of sepsis in the elderly focusing on senescence of hematopoietic stem cell.Principal Investigator

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Clarification of the mechanism of functional impairment of macrophages in sepsis and development of novel therapeutics

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In silico screening of Interleukin-15 mimetics and application for a treatment of elderly septic patientsPrincipal Investigator

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Research directed toward developing immune-recovery treatment based on inhibiting a glycosidease

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A novel therapeutic strategy for sepsis with re-activating T cells in the elderlyPrincipal Investigator

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Immunoanalysis of severe septic patients in the elderly and therapeutic potential of IL-15Principal Investigator

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[Journal Article] Usefulness of next-generation DNA sequencing for the diagnosis of urinary tract infection2020

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[Journal Article] Papaverine identified as an inhibitor of high mobility group box 1/receptor for advanced glycation end-products interaction suppresses high mobility group box 1-mediated inflammatory responses2019

Author(s)

Inoue Shigeaki 井上茂亮

INOUE Shigeaki 井上茂亮

[Presentation] 肺癌手術において麻酔薬が術後の免疫抑制に及ぼす影響　-単施設前向き観察研究-2019