Inoue Shigeaki 井上茂亮

… Alternative Names

INOUE Shigeaki 井上茂亮

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Researcher Number	30582209
Other IDs
Affiliation (Current)	2025: 和歌山県立医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 和歌山県立医科大学, 医学部, 教授 2018 – 2023: 神戸大学, 医学研究科, 特命教授 2014 – 2021: 東海大学, 医学部, 准教授 2011 – 2013: 東海大学, 創造科学技術研究機構, 講師
Review Section/Research Field	Principal Investigator Basic Section 55060:Emergency medicine-related / Emergency medicine Except Principal Investigator Basic Section 55050:Anesthesiology-related / Basic Section 55060:Emergency medicine-related / Basic Section 58010:Medical management and medical sociology-related / Basic Section 55020:Digestive surgery-related / Tumor diagnostics / Anesthesiology
Keywords	Principal Investigator 敗血症 / 老化 / IL-15 / 免疫 / T細胞 / 高齢者 / 脳内炎症 / 加齢 / 集中治療後症候群 / リンパ球 … More / 精神障害 / 身体機能障害 / 敗血症性脳症 / 敗血症、 / 造血幹細胞 / ミメティクス / 炎症 / 免疫疲弊 / In silico screening / SOCS1 / 免疫抑制 … More Except Principal Investigator PICS / 敗血症 / 長期予後 / 生活の質 / 機能障害 / 集中治療後症候群 / 大腸癌 / 麻酔薬 / 肺がん手術 / 肺がん / 免疫抑制 / マクロファージ / 感染症 / 筋肉萎縮 / PICS(集中治療後症候群) / 筋肉 / 好中球 / PICS-F / 重症患者 / レミマゾラム / インターロイキン１５ / 免疫チェックポイント阻害剤 / Il-15 / 胃癌 / 抗腫瘍免疫応答 / インターロイキン15 / T細胞 / 免疫賦活 / サルコペニア / IL-15 / 胃癌・大腸癌 / 高齢者 / 腫瘍浸潤T細胞 / 組織滞在型メモリーT細胞 / CD8 T細胞 / レジデントメモリ-T細胞 / CD8+T細胞 / インフルエンザワクチン / CD8+細胞 / 肺転移 / 腫瘍浸潤リンパ球 / AIイメージサイトメトリー / レジデントメモリーT細胞 / 腫瘍微小環境 / NKT細胞 / がんワクチン / 抗体 / 感染菌 / MRSA / 多剤耐性菌 / クオラムセンシング / ペプチドグリカン / 抗菌活性 / 膜タンパク質 / 活性抗体 / 薬剤耐性 / モノクローナル抗体 / 予後 / サイトカイン / 白血球 / 手術 / 免疫老化 / デスフルラン / セボフルラン / プロポフォール / 肺癌手術 / αガラクトサミニダーゼ / 酵素阻害剤 / αガラクトサミニザーゼ / マクロファージ活性化因子 / 酵素阻害 / 免疫療法 / がん / 高齢化 / 炎症 / ハイスループットスクリーニング / 自己免疫疾患 / 抗原提示 Less

集中治療後症候群データベースの集学的研究
- Principal Investigator
  
  畠山淳司
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58010:Medical management and medical sociology-related
- Research Institution
  Osaka Medical and Pharmaceutical University
集中治療室に入室した患者家族の精神障害(PICS-F)の病態解明と予防バンドルの開発
- Principal Investigator
  
  白崎加純
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  St. Luke's International University
高齢敗血症患者における筋委縮の病態解明とマイオカインを活用したPICS治療法の探索Principal Investigator
- Principal Investigator
  
  井上茂亮
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Wakayama Medical University
PICSにおける好中球の筋肉内浸潤の病態解明と好中球遊走制御による新たな治療法の確立
- Principal Investigator
  
  小谷穣治
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kobe University
麻酔薬による肺がん患者免疫抑制の機序解明―プロポフォールとレミマゾラムを軸に
- Principal Investigator
  
  川越いづみ
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Juntendo University
重症患者の長期予後改善を見据えたデータベースの構築
- Principal Investigator
  
  畠山淳司
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58010:Medical management and medical sociology-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Mechanism elucidation of immunostimulatory action by interleukin-15 in the elderly with cancer-bearing condition
- Principal Investigator
  
  Suzuki Satoshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kobe University
A therapeutic strategy of post-intensive care syndrome focused on its mechanism and inflammation regulation in brain.Principal Investigator
- Principal Investigator
  
  Inoue Shigeaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kobe University
A novel cancer immunotherapy focused on organ specific immune memory generation
- Principal Investigator
  
  Yamashita Kimihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kobe University
The impact of intraoperative anesthetics on immune suppression and prognosis in lung cancer patients.
- Principal Investigator
  
  KAWAGOE IZUMI
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Juntendo University
Establishment of antibody-cocktail therapy against invading bacteria for sepsis patients
- Principal Investigator
  
  Watanabe Nobuo
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Tokai University
A novel therapeutic strategy of sepsis in the elderly focusing on senescence of hematopoietic stem cell.Principal Investigator
- Principal Investigator
  
  井上茂亮
- Project Period (FY)
  2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Tokai University
Clarification of the mechanism of functional impairment of macrophages in sepsis and development of novel therapeutics
- Principal Investigator
  
  WATANABE Nobuo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Tokai University
In silico screening of Interleukin-15 mimetics and application for a treatment of elderly septic patientsPrincipal Investigator
- Principal Investigator
  
  INOUE Shigeaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Tokai University
Research directed toward developing immune-recovery treatment based on inhibiting a glycosidease
- Principal Investigator
  
  Kanie Osamu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor diagnostics
- Research Institution
  Tokai University
A novel therapeutic strategy for sepsis with re-activating T cells in the elderlyPrincipal Investigator
- Principal Investigator
  
  INOUE Shigeaki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Tokai University
Immunoanalysis of severe septic patients in the elderly and therapeutic potential of IL-15Principal Investigator
- Principal Investigator
  
  INOUE Shigeaki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Tokai University

All 2024 2023 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Post‐intensive care syndrome: Recent advances and future directions2024
- Author(s)
  Inoue Shigeaki、Nakanishi Nobuto、Amaya Fumimasa、Fujinami Yoshihisa、Hatakeyama Junji、Hifumi Toru、Iida Yuki、Kawakami Daisuke、Kawai Yusuke、Kondo Yutaka、Liu Keibun、Nakamura Kensuke、Nishida Takeshi、Sumita Hidenori、Taito Shunsuke、Takaki Shunsuke、Tsuboi Norihiko、Unoki Takeshi、Yoshino Yasuyo、Nishida Osamu
- Journal Title
  
  Acute Medicine & Surgery
  
  Volume: 11 Issue: 1 Pages: 929-929
- DOI
  10.1002/ams2.929
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K10455, KAKENHI-PROJECT-20K21635, KAKENHI-PROJECT-20K17899, KAKENHI-PROJECT-21H03026
[Journal Article] Sepsis Induces Physical and Mental Impairments in a Mouse Model of Post-Intensive Care Syndrome2021
- Author(s)
  Yoshihisa Fujinami, Shigeaki Inoue, Yuko Ono, Yusuke Miyazaki, Kazumichi Fujioka, Kimihiro Yamashita, Joji Kotani
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 10 Issue: 8 Pages: 1593-1593
- DOI
  10.3390/jcm10081593
- NAID
  120007035637
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09414, KAKENHI-PROJECT-18K16544, KAKENHI-PROJECT-20H03781, KAKENHI-PROJECT-20K08229
[Journal Article] Malocclusion of Molar Teeth Is Associated with Activities of Daily Living Loss and Delirium in Elderly Critically Ill Older Patients2021
- Author(s)
  Fujinami Yoshihisa、Hifumi Toru、Ono Yuko、Saito Masafumi、Okazaki Tomoya、Shinohara Natsuyo、Akiyama Kyoko、Kunikata Misa、Inoue Shigeaki、Kotani Joji、Kuroda Yasuhiro
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 10 Issue: 10 Pages: 2157-2157
- DOI
  10.3390/jcm10102157
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16544, KAKENHI-PROJECT-20H03781
[Journal Article] Post-Intensive Care Syndrome and Its New Challenges in Coronavirus Disease 2019 (COVID-19) Pandemic: A Review of Recent Advances and Perspectives2021
- Author(s)
  Nakanishi Nobuto、Liu Keibun、Kawakami Daisuke、Kawai Yusuke、Morisawa Tomoyuki、Nishida Takeshi、Sumita Hidenori、Unoki Takeshi、Hifumi Toru、Iida Yuki、Katsukawa Hajime、Nakamura Kensuke、Ohshimo Shinichiro、Hatakeyama Junji、Inoue Shigeaki、Nishida Osamu
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 10 Issue: 17 Pages: 3870-3870
- DOI
  10.3390/jcm10173870
- NAID
  120007148942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03781, KAKENHI-PROJECT-20K17899
[Journal Article] Propofol decreases CD8+ T cells and sevoflurane increases regulatory T cells after lung cancer resection: a randomized controlled trial2021
- Author(s)
  Yamaguchi Ai、Kawagoe Izumi、Inoue Shigeaki、Kochiyama Tsukasa、Fukuda Masataka、Saito Masafumi、Hayashida Masakazu
- Journal Title
  
  Journal of Thoracic Disease
  
  Volume: 13 Issue: 9 Pages: 5430-5438
- DOI
  10.21037/jtd-21-878
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08865, KAKENHI-PROJECT-19K18280
[Journal Article] Infiltrated regulatory T cells and Th2 cells in the brain contribute to attenuation of sepsis-associated encephalopathy and alleviation of mental impairments in mice with polymicrobial sepsis2020
- Author(s)
  Saito M, Fujinami Y, Ono Y, Ohyama S, Fujioka K, Yamashita K, Inoue S, Kotani J
- Journal Title
  
  Brain, Behavior, and Immunity
  
  Volume: 92 Pages: 25-38
- DOI
  10.1016/j.bbi.2020.11.010
- NAID
  120006993636
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09414, KAKENHI-PROJECT-20K08229, KAKENHI-PROJECT-18K16544, KAKENHI-PROJECT-20H03781
[Journal Article] Podoplanin is indispensable for cell motility and platelet-induced epithelial-to-mesenchymal transition-related gene expression in esophagus squamous carcinoma TE11A cells2020
- Author(s)
  Watanabe N, Kidokoro M, Tanaka M, Inoue S, Tsuji T, Akatuska H, Okada C, Iida Y, Okada Y, Suzuki Y, Sato T, Yahata T, Hirayama N, Nakagawa Y, Inokuchi S.
- Journal Title
  
  Cancer Cell International
  
  Volume: 20 Issue: 1 Pages: 263-263
- DOI
  10.1186/s12935-020-01328-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08868
[Journal Article] Usefulness of next-generation DNA sequencing for the diagnosis of urinary tract infection2020
- Author(s)
  Ishihara T, Watanabe N, Inoue S, Aoki H, Tsuji T, Yamamoto B, Yanagi H, Oki M1, Kryukov K, Nakagawa S, Inokuchi S, Ozawa H, Imanishi T
- Journal Title
  
  Drug Discoveries & Therapeutics
  
  Volume: 14 Issue: 1 Pages: 42-49
- DOI
  10.5582/ddt.2020.01000
- NAID
  130007802636
- ISSN
  1881-7831, 1881-784X
- Year and Date
  2020-02-29
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08868
[Journal Article] Papaverine identified as an inhibitor of high mobility group box 1/receptor for advanced glycation end-products interaction suppresses high mobility group box 1-mediated inflammatory responses.2019
- Author(s)
  Tamada K, Nakajima S, Ogawa N, Inada M, Shibasaki H, Sato A, Takasawa R, Yoshimori A, Suzuki Y, Watanabe N, Oyama T, Abe H, Inoue S, Abe T, Yokomizo T, Tanuma S.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 511 Issue: 3 Pages: 665-670
- DOI
  10.1016/j.bbrc.2019.01.136
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08868, KAKENHI-PROJECT-18H02685, KAKENHI-PROJECT-16K08327, KAKENHI-PROJECT-19K05737, KAKENHI-PROJECT-19KK0199, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05904, KAKENHI-PROJECT-18H02627
[Journal Article] A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction2019
- Author(s)
  Watanabe N, Kidokoro M, Suzuki Y, Tanaka M, Inoue S, Tsukamoto H, Hirayama N, Hsieh PW, Tseng CP, Nakagawa Y, Inokuchi S
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 9 Pages: e0222331-e0222331
- DOI
  10.1371/journal.pone.0222331
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08868
[Journal Article] Detection of pathogenic bacteria in the blood from sepsis patients using 16S rRNA gene amplicon sequencing analysis.2018
- Author(s)
  Watanabe N, Kryukov K, Nakagawa S, Takeuchi JS, Takeshita M, Kirimura Y, Mitsuhashi S, Ishihara T, Aoki H, Inokuchi S, Imanishi T, Inoue S
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 8 Pages: e0202049-e0202049
- DOI
  10.1371/journal.pone.0202049
- NAID
  120006826803
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08868, KAKENHI-PROJECT-17H07123, KAKENHI-PROJECT-16J40232, KAKENHI-PROJECT-17K15708
[Journal Article] Cha-Koji, comprising green tea leaves fermented with Aspergillus luchuensis var kawachii kitahara, increases regulatory T cell production in mice and humans2018
- Author(s)
  Yamamoto Bunsei、Suzuki Yusuke、Yonezu Takahisa、Mizushima Nanami、Watanabe Nobuo、Sato Takehito、Inoue Shigeaki、Inokuchi Sadaki
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 1 Issue: 5 Pages: 1-8
- DOI
  10.1080/09168451.2018.1443789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10523
[Journal Article] A cell-based high-throughput screening assay system for inhibitor compounds of antigen presentation by HLA class II molecule2017
- Author(s)
  Watanabe Nobuo、Suzuki Yusuke、Yonezu Takahisa、Nakagawa Yuki、Shiina Takashi、Hirayama Noriaki、Inokuchi Sadaki、Inoue Shigeaki
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 6798-6798
- DOI
  10.1038/s41598-017-07080-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06502, KAKENHI-PROJECT-15K10523
[Journal Article] Nitrite administration improves sepsis-induced myocardial and mitochondrial dysfunction by modulating stress signal responses2017
- Author(s)
  Kawaguchi Ryoichi、Hirata Naoyuki、Tokinaga Yasuyuki、Hayashi Shunsuke、Inoue Shigeaki、Watanabe Nobuo、Yamakage Michiaki
- Journal Title
  
  Journal of Anesthesia
  
  Volume: 31 Issue: 6 Pages: 885-894
- DOI
  10.1007/s00540-017-2417-0
- NAID
  40021413831
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10523, KAKENHI-PROJECT-26462367
[Journal Article] Sepsis induces incomplete M2 phenotype polarization in peritoneal exudate cells in mice2016
- Author(s)
  Watanabe N, Suzuki Y, Inokuchi S, Inoue S
- Journal Title
  
  J Intensive Care
  
  Volume: 4 Issue: 1
- DOI
  10.1186/s40560-015-0124-1
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10523
[Journal Article] Persistent inflammation and T cell exhaustion in severe sepsis in the elderly.2014
- Author(s)
  Inoue S, Suzuki K, Komori Y et al:
- Journal Title
  
  Crit Care
  
  Volume: 18 Issue: 3
- DOI
  10.1186/cc13941
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25861735
[Journal Article] Reduction of immunocompetent T cells followed by prolonged lymphopenia in severe sepsis in the elderly2013
- Author(s)
  Inoue S, Suzuki-Utsunomiya K, Okada Y, Iida Y, Taira T, Miura N, Tsuji T, Yamagiwa T, Morita S, Chiba T, Sato T, Inokuchi S
- Journal Title
  
  Crit Care Med
  
  Volume: 41 Pages: 810-819
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23792088
[Journal Article] Reduction of Immunocompetent T Cells Followed by Prolonged Lymphopenia in Severe Sepsis in the Elderly2013
- Author(s)
  Inoue, S.
- Journal Title
  
  Crit Care Med
  
  Volume: 41 Issue: 3 Pages: 810-819
- DOI
  10.1097/ccm.0b013e318274645f
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23792088, KAKENHI-PROJECT-25861735, KAKENHI-PUBLICLY-23118529
[Presentation] 本邦における集中治療後症候群の疫学調査 -JPICSデータベースを用いて-2024
- Author(s)
  畠山淳司、井上茂亮、川上大裕、緒方嘉隆、麻生将太郎
- Organizer
  第51回日本集中治療医学会学術集会
- Data Source
  KAKENHI-PROJECT-22K10455
[Presentation] Prevalence of post-intensive care syndrome in survivors after critical care illness in Japan - A prospective nationwide registry study by JPICS database -2024
- Author(s)
  Junji Hatakeyama, Shigeaki Inoue, Daisuke Kawakami, Yoshitaka Ogata, Shotaro Aso
- Organizer
  43rd International Symposium On Intensive Care and Emergency Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K10455
[Presentation] 重症患者の長期予後データベースの構築 -JPICSデータベース-2023
- Author(s)
  畠山淳司、井上茂亮
- Organizer
  第51回日本救急医学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-22K10455
[Presentation] 加齢と免疫ー呼吸器麻酔を中心にー2020
- Author(s)
  井上茂亮
- Organizer
  第68回日本麻酔科学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08865
[Presentation] 肺癌手術において麻酔薬（デスフルラン、セボフルラン、プロポフォル）が術後の免疫抑制に及ぼす影響　-単施設前向き観察研究2020
- Author(s)
  山口愛　川越いづみ　井上茂亮　河内山宰　福田政孝　三宅幸子　稲田英一
- Organizer
  第68回日本麻酔科学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08865
[Presentation] 肺癌手術において麻酔薬が術後の免疫抑制に及ぼす影響　-単施設前向き観察研究-2019
- Author(s)
  山口愛　川越いづみ　井上茂亮　河内山宰　福田征孝　稲田英一
- Organizer
  第67回日本麻酔科学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08865
[Presentation] 高齢者敗血症では疲弊したT細胞とICUでの２次感染が増加する。2015
- Author(s)
  井上　茂亮
- Organizer
  第42回日本集中治療医学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-02-10
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] 新たな免疫強化療法としての抗Programed death-1抗体の可能性～高齢者敗血症の治療法を探る2014
- Author(s)
  井上　茂亮
- Organizer
  日本老年医学会
- Place of Presentation
  福岡県福岡市
- Year and Date
  2014-06-13
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] Persistent inflammation and t cell exhaustion in severe sepsis in the elderly2014
- Author(s)
  Shigeaki Inoue
- Organizer
  米国ショック学会
- Place of Presentation
  米国　シャーロット
- Year and Date
  2014-06-09
- Invited
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] インターロイキン15は、インターフェロンγの産生とSTAT5のリン酸化を促進することで、加齢に伴うT細胞活性化障害を改善する2014
- Author(s)
  井上　茂亮
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島　鹿児島大学
- Invited
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] 高齢者敗血症患者における炎症と免疫抑制の病態生理2014
- Author(s)
  井上　茂亮
- Organizer
  第42日本救急医学会総会・学術集会
- Place of Presentation
  福岡県福岡市
- Year and Date
  2014-10-29
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] 免疫老化と高齢者敗血症 -病態と治療への免疫学的アプローチ2014
- Author(s)
  井上　茂亮
- Organizer
  第66回日本皮膚科学会西部支部学術大会
- Place of Presentation
  香川県高松市
- Year and Date
  2014-11-09
- Invited
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] Prolonged hypothermia and hypercytokinemia with apoptosis of lymphocytes in aged septic mice2013
- Author(s)
  Shigeaki Inoue
- Organizer
  Society of Critical Care Medicine’s 42nd Critical Care Congress
- Place of Presentation
  米国　プエルトリコ　サンファン
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] Interleukin 15 reverses age-related impairment T cell inactivation and proliferation with increasing pSTAT5 in elderly septic patients2013
- Author(s)
  Shigeaki Inoue
- Organizer
  15th Congress of the European Shock Society
- Place of Presentation
  オーストリア　ウィーン・Medical University of Vienna
- Invited
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] Interleukin 15 reverses age-related CD8+ T cell inactivation with increasing interferon-gamma production and improves survival in aged septic mice2013
- Author(s)
  Shigeaki Inoue
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  イタリア　ミラノ
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] Interleukin 15 reverses age-related T cell inactivation with increasing interferon-gamma and pSTAT3/5 production, and promotes T cell proliferation from septic patients in the elderly2013
- Author(s)
  Shigeaki Inoue
- Organizer
  15th Congress of the European Shock Society
- Place of Presentation
  オーストリア　ウィーン
- Invited
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] 敗血症における加齢の影響2013
- Author(s)
  井上　茂亮
- Organizer
  第28回日本Shock学会総会
- Place of Presentation
  東京　北里大学薬学部
- Invited
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] Prolonged elevation of serum Interleukin 6 and impairment of Tcell activation in elderly Patients with sepsis2013
- Author(s)
  Shigeaki Inoue
- Organizer
  第7回ｱｼﾞｱ救急医学会（ACEM2013)
- Place of Presentation
  東京東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] 本邦のショック領域からのクリニカルトライアルを目指して2013
- Author(s)
  井上　茂亮
- Organizer
  第28回日本Shock学会総会
- Place of Presentation
  東京都港区
- Invited
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] Reduction of immunocompetent T cells followed by prolonged lymphopenia in severe sepsis in the elderly2013
- Author(s)
  Shigeaki Inoue
- Organizer
  36th Annual Conference on Shock
- Place of Presentation
  アメリカ　サンディエゴ　Sheraton San Diego Hotel & Marina
- Invited
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] Reduction of immunocompetent T cells followed by prolonged lymphopenia in severe sepsis in the elderly2013
- Author(s)
  Shigeaki Inoue
- Organizer
  36th Annual Conference on Shock
- Place of Presentation
  米国　サンディエゴ
- Invited
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] Interleukin 15 reverses age-related CD8+ T cell inactivation with increasing interferon-gamma production and improves survival in aged septic mice2013
- Author(s)
  Shigeaki Inoue
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  イタリア　ミラノ　Mico-Milano Congressi
- Invited
- Data Source
  KAKENHI-PROJECT-25861735
[Presentation] 高齢者敗血症における免疫機能解析2012
- Author(s)
  井上　茂亮
- Organizer
  第27回日本Shock学会総会
- Place of Presentation
  東京都千代田区
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] 高齢者敗血症における末梢血単核球の免疫機能解析2012
- Author(s)
  井上茂亮鈴木恭子小森由香子井口貞樹
- Organizer
  第39回日本集中治療医学会学術集会
- Place of Presentation
  千葉幕張メッセ
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] 高齢マウス敗血症モデルにおける免疫抑制のメカニズムを探る。2012
- Author(s)
  井上　茂亮
- Organizer
  第27回日本Shock学会総会
- Place of Presentation
  東京都千代田区
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] IL-15は免疫応答細胞のアポトーシスを抑制し、高齢マウス敗血症の生命予後を改善する2012
- Author(s)
  井上　茂亮
- Organizer
  第19回外科侵襲とサイトカイン研究会
- Place of Presentation
  兵庫県神戸市
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation]2012
- Author(s)
  Inoue S, Suzuki-Utsumoniya K, Komori Y, Sato T, Inokuchi S
- Organizer
  日本外科代謝栄養学会第49回学術集会日韓合同シンポジウム講演
- Place of Presentation
  千葉
- Year and Date
  2012-07-06
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] Reduction and functional impairment of T cells in severe sepsis in the elderly2012
- Author(s)
  Shigeaki Inoue
- Organizer
  第49回日本外科代謝栄養学学術集会
- Place of Presentation
  千葉県浦安市
- Invited
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] Increased apoptosis of lymphocytes and prolonged cytokinemia in aged mice with sepsis2012
- Author(s)
  Shigeaki Inoue
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  兵庫県神戸市
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] Klothoマウス敗血症モデルにおける免疫機能解析2011
- Author(s)
  井上　茂亮
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  千葉県千葉市幕張メッセ
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] 高齢者敗血症における末梢血単核球の免疫機能解析2011
- Author(s)
  井上　茂亮
- Organizer
  第39回日本集中治療医学会学術集会
- Place of Presentation
  千葉県千葉市幕張メッセ
- Data Source
  KAKENHI-PROJECT-23792088
[Presentation] 免疫老化が敗血症に与える影響
- Author(s)
  井上　茂亮
- Organizer
  第２９回日本ショック学会
- Place of Presentation
  愛媛県松山市
- Year and Date
  2014-05-16 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-25861735

1. Yamashita Kimihiro (80535427)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 西田修 (20208185)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. WATANABE Nobuo (80396928)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. KAWAGOE IZUMI (10445520)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
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# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. 福田征孝 (80822296)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. 掛地吉弘 (80284488)

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8. 小谷穣治 (80360270)

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9. 酒井良忠 (90397802)

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11. 田上隆 (40626272)

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12. 河合佑亮 (60940088)

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13. Kanie Osamu (90291062)

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22. 曽良一郎 (40322713)

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23. 黒田泰弘 (80234615)

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34. 椎名隆

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# of Collaborated Products: 1 results

Inoue Shigeaki 井上 茂亮

INOUE Shigeaki 井上 茂亮

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高齢敗血症患者における筋委縮の病態解明とマイオカインを活用したPICS治療法の探索Principal Investigator

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A therapeutic strategy of post-intensive care syndrome focused on its mechanism and inflammation regulation in brain.Principal Investigator

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A novel therapeutic strategy of sepsis in the elderly focusing on senescence of hematopoietic stem cell.Principal Investigator

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In silico screening of Interleukin-15 mimetics and application for a treatment of elderly septic patientsPrincipal Investigator

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Inoue Shigeaki 井上茂亮

INOUE Shigeaki 井上茂亮