HAYASHI TOMOATSU 林寛敦

… Alternative Names

Hayashi Tomoatsu 林寛敦

Less

Researcher Number	30583215
Other IDs
Affiliation (Current)	2025: 東京大学, 定量生命科学研究所, 特任助教
Affiliation (based on the past Project Information) *help	2018 – 2024: 東京大学, 定量生命科学研究所, 特任助教 2017: 東京大学, 分子細胞生物学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related Except Principal Investigator Basic Section 56020:Orthopedics-related / Complex systems
Keywords	Principal Investigator 1細胞遺伝子発現解析 / 転写因子 / 可塑性 / がん幹細胞 / 大腸がん / 卵巣明細胞癌 / 卵巣癌 / Apoptosis / 卵巣明細胞がん / 卵巣がん / Phosphate transporter / XPR1 … More Except Principal Investigator … More 肺転移 / オルガノイド / 肉腫幹細胞 / 浸潤 / 転移 / オルガノイドモデル / 幹細胞 / 肉腫 / シグナル伝達 / 癌幹細胞 / scRNA-seq / 細胞・組織 / 癌 / 線維芽細胞 / 免疫細胞 / 細胞間相互作用 / 1細胞解析 / non-coding RNA / 造腫瘍能 / がん幹細胞 / がん / 腫瘍内不均一性 / がん微小環境 / 1細胞RNA-seq Less

Study of the regulatory mechanisms of colorectal cancer cell plasticity focusing on transcription factors identified by single-cell analysis.Principal Investigator
- Principal Investigator
  
  林寛敦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  The University of Tokyo
Study of the Phosphate Exporter XPR1 function in Ovarian CancerPrincipal Investigator
- Principal Investigator
  
  Hayashi Tomoatsu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  The University of Tokyo
Elucidation of mechanisms of sarcoma progression and metastasis using human sarcoma stem cells and organoid models
- Principal Investigator
  
  Matsumine Akihiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  University of Fukui
Single-cell analysis of tumor heterogeneity arising from the evolution of cancer stem cells
- Principal Investigator
  
  Akiyama Tetsu
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2019 2018 2017 Other

All Journal Article Presentation Book Other

[Book] がん微小環境に１細胞レベルで挑む2021
- Author(s)
  林寛敦, 秋山徹 (分担執筆、藤田　直也/編)
- Total Pages
  220
- Publisher
  羊土社
- ISBN
  9784758103961
- Data Source
  KAKENHI-PLANNED-17H06325
[Book] シングルセルゲノミクス「11. シングルセル遺伝子発現解析からみえてきた腫瘍内不均一性」2019
- Author(s)
  林寛敦、秋山徹
- Total Pages
  219
- Publisher
  羊土社
- ISBN
  9784758103831
- Data Source
  KAKENHI-PLANNED-17H06325
[Journal Article] LncRNA ZNNT1 induces p53 degradation by interfering with the interaction between p53 and the SART3-USP15 complex2023
- Author(s)
  Taniue Kenzui、Oda Takeaki、Hayashi Tomoatsu、Kamoshida Yuki、Takeda Yasuko、Sugawara Anzu、Shimoura Yuki、Negishi Lumi、Nagashima Takeshi、Okada-Hatakeyama Mariko、Kawamura Yoshifumi、Goshima Naoki、Akimitsu Nobuyoshi、Akiyama Tetsu
- Journal Title
  
  PNAS Nexus
  
  Volume: 2 Issue: 7
- DOI
  10.1093/pnasnexus/pgad220
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07146
[Journal Article] The splicing factor DHX38/PRP16 is required for ovarian clear cell carcinoma tumorigenesis, as revealed by a CRISPR‐Cas9 screen2022
- Author(s)
  Cona Brandon、Hayashi Tomoatsu、Yamada Ai、Shimizu Naomi、Yokota Naoko、Nakato Ryuichiro、Shirahige Katsuhiko、Akiyama Tetsu
- Journal Title
  
  FEBS Open Bio
  
  Volume: 12 Issue: 3 Pages: 582-593
- DOI
  10.1002/2211-5463.13358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06325, KAKENHI-PLANNED-17H06331, KAKENHI-PROJECT-21H02693
[Journal Article] CRISPR/Cas9 Screening for Identification of Genes Required for the Growth of Ovarian Clear Cell Carcinoma Cells2022
- Author(s)
  Kawabata Ayako、Hayashi Tomoatsu、Akasu-Nagayoshi Yoko、Yamada Ai、Shimizu Naomi、Yokota Naoko、Nakato Ryuichiro、Shirahige Katsuhiko、Okamoto Aikou、Akiyama Tetsu
- Journal Title
  
  Current Issues in Molecular Biology
  
  Volume: 44 Issue: 4 Pages: 1587-1596
- DOI
  10.3390/cimb44040108
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-21H02693, KAKENHI-PROJECT-21K07146
[Journal Article] SIPA1L1/SPAR1 Interacts with the Neurabin Family of Proteins and is Involved in GPCR Signaling2022
- Author(s)
  Matsuura　K., Kobayashi S., Konno K., Yamasaki M., Horiuchi T., Senda T., Hayashi T., Satoh K., Arima-Yoshida F., Iwasaki K., Negishi L., Yasui-Shimizu N., Kohu K., Kawahara S., Kirino Y., Nakamura T., Watanabe M., Yamamoto T., Manabe T. and Akiyama T.
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 42 Issue: 12 Pages: 2448-2473
- DOI
  10.1523/jneurosci.0569-21.2022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06901, KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-19H03321, KAKENHI-PROJECT-21H02693, KAKENHI-PROJECT-20H03410
[Journal Article] The phosphate exporter XPR1/SLC53A1 is required for the tumorigenicity of epithelial ovarian cancer2022
- Author(s)
  Akasu‐Nagayoshi Yoko、Hayashi Tomoatsu、Kawabata Ayako、Shimizu Naomi、Yamada Ai、Yokota Naoko、Nakato Ryuichiro、Shirahige Katsuhiko、Okamoto Aikou、Akiyama Tetsu
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 6 Pages: 2034-2043
- DOI
  10.1111/cas.15358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-21H02693, KAKENHI-PROJECT-21K07146
[Journal Article] Codependency and mutual exclusivity for gene community detection from sparse single-cell transcriptome data2021
- Author(s)
  Nakajima N, Hayashi T, Fujiki K, Shirahige K, Akiyama T, Akutsu T, Nakato R.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 49 Issue: 18 Pages: e104-e104
- DOI
  10.1093/nar/gkab601
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21384, KAKENHI-PLANNED-17H06325, KAKENHI-PLANNED-17H06331, KAKENHI-PLANNED-20H05940, KAKENHI-PROJECT-21H02693
[Journal Article] UHRF1-KAT7-mediated regulation of TUSC3 expression via histone methylation/acetylation is critical for the proliferation of colon cancer cells2019
- Author(s)
  Taniue Kenzui、Hayashi Tomoatsu、Kamoshida Yuki、Kurimoto Akiko、Takeda Yasuko、Negishi Lumi、Iwasaki Kei、Kawamura Yoshifumi、Goshima Naoki、Akiyama Tetsu
- Journal Title
  
  Oncogene
  
  Volume: 39 Issue: 5 Pages: 1018-1030
- DOI
  10.1038/s41388-019-1032-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K15804, KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-17H01537, KAKENHI-ORGANIZER-17H06324
[Journal Article] Sp5 negatively regulates the proliferation of HCT116 cells by upregulating the transcription of p272018
- Author(s)
  Miyamoto M, Hayashi T, Kawasaki Y, Akiyama T.
- Journal Title
  
  Oncol Lett.
  
  Volume: 15 Pages: 4005-4009
- DOI
  10.3892/ol.2018.7793
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19584, KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-17H01537, KAKENHI-PROJECT-16H04692
[Journal Article] Somatic copy number alterations have prognostic impact in patients with ovarian clear cell carcinoma2018
- Author(s)
  Morikawa Asuka、Hayashi Tomoatsu、Kobayashi Mana、Kato Yuki、Shirahige Katsuhiko、Itoh Takehiko、Urashima Mitsuyoshi、Okamoto Aikou、Akiyama Tetsu
- Journal Title
  
  Oncology Reports
  
  Volume: 40 Pages: 309-318
- DOI
  10.3892/or.2018.6419
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-17H01537
[Journal Article] PIK3CA and KRAS mutations in cell free circulating DNA are useful markers for monitoring ovarian clear cell carcinoma.2018
- Author(s)
  Morikawa A., Hayashi T., Shimizu N., Kobayashi M., Taniue K., Takahashi A., Tachibana K., Saito M., Kawabata A., Iida Y., Ueda K., Saito M., Yanaihara N., Tanabe H., Yamada K., Takano H., Nureki O., Okamoto A. and Akiyama T.
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 20 Pages: 15266-15274
- DOI
  10.18632/oncotarget.24555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-15K08299, KAKENHI-PROJECT-17H01537
[Journal Article] Somatic copy number alterations have prognostic impact in patients with ovarian clear cell carcinoma.2018
- Author(s)
  Morikawa A., Hayashi T., Kobayashi M., Kato Y., Shirahige K., Itoh T., Urashima M., Okamoto A., Akiyama T.
- Journal Title
  
  Oncology Reports
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06325
[Presentation] Identification and analysis of genes required for the growth of ovarian cancer cells by CRISPR/Cas9 screening2022
- Author(s)
  Tomoatsu Hayashi, Yoko Akasu-Nagayoshi, Ayako Kawabata, Aikou Okamoto and Tetsu Akiyama.
- Organizer
  The 81st Annual Meeting of the Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-21K07146
[Presentation] 1細胞発現解析による卵巣がんの多様性の理解2022
- Author(s)
  林　寛敦、川畑　絢子、藤木　克則、中戸　隆一郎、白髭　克彦、岡本　愛光、秋山　徹
- Organizer
  第4回がん三次元培養研究会
- Data Source
  KAKENHI-PROJECT-21K07146
[Presentation] CRISPR/Cas9スクリーニングによる卵巣明細胞がんに対する新規治療法的分子の同定2022
- Author(s)
  林　寛敦
- Organizer
  第21回東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K07146
[Presentation] 1細胞 RNA-seq による腫瘍内不均一性の理解への取り組み2019
- Author(s)
  林寛敦
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PLANNED-17H06325
[Presentation] がん幹細胞を標的としたSIRT2阻害剤の開発2019
- Author(s)
  林寛敦、秋山徹
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PLANNED-17H06325
[Presentation] 1細胞シーケンス解析による腫瘍内不均一性の理解に向けた取り組み2019
- Author(s)
  林寛敦、秋山徹
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-17H06325
[Presentation] 数理科学的手法を取り入れた1細胞RNA-seqデータの統合的解析への取り組み2018
- Author(s)
  林寛敦、川崎秀二、仲嶋なつ、中戸隆一郎、秋山徹
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-17H06325
[Presentation] がん組織とがん幹細胞の分化モデルを用いた１細胞RNA-seq解析2018
- Author(s)
  林　寛敦、秋山徹
- Organizer
  新学術領域研究「細胞社会ダイバーシティーの統合的解明と制御」　若手ワークショップ
- Data Source
  KAKENHI-PLANNED-17H06325
[Presentation] がん組織とがん幹細胞の分化モデルを用いた１細胞RNA-seq解析2018
- Author(s)
  林　寛敦、秋山徹
- Organizer
  新学術領域研究「細胞社会ダイバーシティーの統合的解明と制御」　第一回公開シンポジウム
- Data Source
  KAKENHI-PLANNED-17H06325
[Presentation] がん幹細胞を標的とした分子標的薬の開発2017
- Author(s)
  林　寛敦、秋山徹
- Organizer
  第76回日本癌学会学術総会　コアシンポジウム「新たなステージに入ったがん幹細胞研究」
- Data Source
  KAKENHI-PLANNED-17H06325
[]

1. Akiyama Tetsu (70150745)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
2. Matsumine Akihiko (00335118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 出淵雄哉 (20795041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KAWASAKI Yoshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 鴨志田祐己

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 小林静香

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 藤木克則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HAYASHI TOMOATSU 林 寛敦

Hayashi Tomoatsu 林 寛敦

Research Projects

Research Products

Co-Researchers

Study of the regulatory mechanisms of colorectal cancer cell plasticity focusing on transcription factors identified by single-cell analysis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of the Phosphate Exporter XPR1 function in Ovarian CancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mechanisms of sarcoma progression and metastasis using human sarcoma stem cells and organoid models

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Single-cell analysis of tumor heterogeneity arising from the evolution of cancer stem cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] がん微小環境に１細胞レベルで挑む2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] シングルセルゲノミクス「11. シングルセル遺伝子発現解析からみえてきた腫瘍内不均一性」2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] LncRNA ZNNT1 induces p53 degradation by interfering with the interaction between p53 and the SART3-USP15 complex2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The splicing factor DHX38/PRP16 is required for ovarian clear cell carcinoma tumorigenesis, as revealed by a CRISPR‐Cas9 screen2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CRISPR/Cas9 Screening for Identification of Genes Required for the Growth of Ovarian Clear Cell Carcinoma Cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SIPA1L1/SPAR1 Interacts with the Neurabin Family of Proteins and is Involved in GPCR Signaling2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The phosphate exporter XPR1/SLC53A1 is required for the tumorigenicity of epithelial ovarian cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Codependency and mutual exclusivity for gene community detection from sparse single-cell transcriptome data2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] UHRF1-KAT7-mediated regulation of TUSC3 expression via histone methylation/acetylation is critical for the proliferation of colon cancer cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sp5 negatively regulates the proliferation of HCT116 cells by upregulating the transcription of p272018

Author(s)

Journal Title

DOI

HAYASHI TOMOATSU 林寛敦

Hayashi Tomoatsu 林寛敦